ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oxygen transport (GO:0015671)	5.84743128
2	positive regulation of prostaglandin secretion (GO:0032308)	5.59272387
3	proteasome assembly (GO:0043248)	5.19384228
4	gas transport (GO:0015669)	4.85171242
5	rRNA modification (GO:0000154)	4.53880716
6	regulation of prostaglandin secretion (GO:0032306)	4.47954920
7	ATP synthesis coupled proton transport (GO:0015986)	4.46751792
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.46751792
9	positive regulation of heat generation (GO:0031652)	4.23327946
10	ribosomal small subunit assembly (GO:0000028)	4.19266209
11	NADH dehydrogenase complex assembly (GO:0010257)	4.05586961
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.05586961
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.05586961
14	positive regulation of icosanoid secretion (GO:0032305)	3.98101909
15	DNA deamination (GO:0045006)	3.96775156
16	maturation of 5.8S rRNA (GO:0000460)	3.87956594
17	positive regulation of fatty acid transport (GO:2000193)	3.86792649
18	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.84507083
19	regulation of mitotic spindle checkpoint (GO:1903504)	3.84507083
20	S-adenosylmethionine metabolic process (GO:0046500)	3.83716190
21	aspartate family amino acid biosynthetic process (GO:0009067)	3.79273834
22	rRNA methylation (GO:0031167)	3.78474336
23	ribosomal large subunit biogenesis (GO:0042273)	3.78284475
24	regulation of fever generation (GO:0031620)	3.75046944
25	protein-cofactor linkage (GO:0018065)	3.74543543
26	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.72122600
27	protein complex biogenesis (GO:0070271)	3.68595829
28	mannosylation (GO:0097502)	3.67079267
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.66943697
30	protein neddylation (GO:0045116)	3.65847582
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.58530563
32	ubiquinone biosynthetic process (GO:0006744)	3.55034026
33	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.47217714
34	termination of RNA polymerase III transcription (GO:0006386)	3.47217714
35	fucose catabolic process (GO:0019317)	3.40413295
36	L-fucose metabolic process (GO:0042354)	3.40413295
37	L-fucose catabolic process (GO:0042355)	3.40413295
38	iron-sulfur cluster assembly (GO:0016226)	3.38125909
39	metallo-sulfur cluster assembly (GO:0031163)	3.38125909
40	viral transcription (GO:0019083)	3.33840542
41	preassembly of GPI anchor in ER membrane (GO:0016254)	3.27813005
42	electron transport chain (GO:0022900)	3.27714294
43	translational termination (GO:0006415)	3.27593656
44	respiratory electron transport chain (GO:0022904)	3.24766736
45	regulation of heat generation (GO:0031650)	3.23557683
46	heart process (GO:0003015)	3.23136074
47	heart contraction (GO:0060047)	3.23136074
48	mitochondrial respiratory chain complex assembly (GO:0033108)	3.19029632
49	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.17532070
50	homocysteine metabolic process (GO:0050667)	3.15852607
51	response to xenobiotic stimulus (GO:0009410)	3.15820850
52	endothelium development (GO:0003158)	3.07315185
53	interleukin-1-mediated signaling pathway (GO:0070498)	3.05168286
54	translational elongation (GO:0006414)	3.02941199
55	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.98773168
56	cotranslational protein targeting to membrane (GO:0006613)	2.98123014
57	methionine biosynthetic process (GO:0009086)	2.96184779
58	inner mitochondrial membrane organization (GO:0007007)	2.91029820
59	protein targeting to ER (GO:0045047)	2.90907546
60	mitochondrial RNA metabolic process (GO:0000959)	2.89047347
61	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.88161926
62	ATP biosynthetic process (GO:0006754)	2.88091120
63	GMP metabolic process (GO:0046037)	2.85883400
64	protein localization to endoplasmic reticulum (GO:0070972)	2.84849671
65	branched-chain amino acid catabolic process (GO:0009083)	2.83618115
66	ubiquinone metabolic process (GO:0006743)	2.81203115
67	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.79769060
68	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.79433740
69	quinone biosynthetic process (GO:1901663)	2.78377449
70	regulation of icosanoid secretion (GO:0032303)	2.76836249
71	ribosomal small subunit biogenesis (GO:0042274)	2.75709796
72	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.74315865
73	regulation of cellular amino acid metabolic process (GO:0006521)	2.73888620
74	negative regulation of mast cell activation (GO:0033004)	2.72652716
75	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.72634057
76	ketone body metabolic process (GO:1902224)	2.71728075
77	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.71048471
78	translational initiation (GO:0006413)	2.70484854
79	hydrogen ion transmembrane transport (GO:1902600)	2.68455619
80	transcription from mitochondrial promoter (GO:0006390)	2.67939174
81	cellular component biogenesis (GO:0044085)	2.67078904
82	regulation of interleukin-8 secretion (GO:2000482)	2.66966166
83	translation (GO:0006412)	2.65166078
84	maturation of SSU-rRNA (GO:0030490)	2.64106024
85	GPI anchor biosynthetic process (GO:0006506)	2.64052764
86	AMP metabolic process (GO:0046033)	2.63815175
87	piRNA metabolic process (GO:0034587)	2.63713673
88	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.63134776
89	purine-containing compound salvage (GO:0043101)	2.62526952
90	positive regulation of interleukin-8 secretion (GO:2000484)	2.61585919
91	respiratory chain complex IV assembly (GO:0008535)	2.60571446
92	cellular ketone body metabolic process (GO:0046950)	2.60406029
93	oxidative phosphorylation (GO:0006119)	2.60243219
94	protein targeting to mitochondrion (GO:0006626)	2.59329066
95	proton transport (GO:0015992)	2.58578382
96	hydrogen transport (GO:0006818)	2.55922968
97	replication fork processing (GO:0031297)	2.55656011
98	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.54561606
99	deoxyribose phosphate biosynthetic process (GO:0046385)	2.54561606
100	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.53860603

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.60536021
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.39674115
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.23627697
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.80337126
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.66468330
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.65508761
7	VDR_22108803_ChIP-Seq_LS180_Human	3.48292711
8	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.17422804
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.99987358
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.97618792
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94613143
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.80324089
13	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.76931569
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.63229930
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.30485494
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.27794722
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.23520281
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.01569127
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.95967246
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.85846864
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.78962971
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.73957917
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.73207184
24	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.72137169
25	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.72093062
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71062524
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69104470
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68376708
29	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.61682275
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.58014510
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54612374
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54265884
33	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.53790168
34	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.52561482
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.52205696
36	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.49025683
37	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.39779145
38	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.35911766
39	AR_20517297_ChIP-Seq_VCAP_Human	1.33858587
40	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.32196483
41	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.31166814
42	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.30756173
43	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.29205093
44	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.28617997
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28280022
46	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.26464434
47	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.26055877
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.26002082
49	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.24726206
50	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.23771456
51	XRN2_22483619_ChIP-Seq_HELA_Human	1.23110364
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22873312
53	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.22268043
54	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.21012873
55	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.21012873
56	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.21012873
57	DCP1A_22483619_ChIP-Seq_HELA_Human	1.19647078
58	RBPJ_21746931_ChIP-Seq_IB4_Human	1.16150320
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.14627293
60	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.14374967
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12837719
62	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10982321
63	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.10750721
64	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09300820
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09107978
66	GATA1_19941826_ChIP-Seq_K562_Human	1.08718999
67	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.06789099
68	GATA3_26560356_Chip-Seq_TH2_Human	1.06704810
69	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.05936955
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05377236
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05213257
72	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.02779110
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01424477
74	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.98660496
75	PHF8_20622853_ChIP-Seq_HELA_Human	0.98475626
76	EGR1_19032775_ChIP-ChIP_M12_Human	0.97726502
77	EWS_26573619_Chip-Seq_HEK293_Human	0.95595516
78	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.95327829
79	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94454898
80	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.93701580
81	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93390286
82	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93353679
83	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.93243344
84	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91996288
85	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.91955430
86	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91390806
87	HTT_18923047_ChIP-ChIP_STHdh_Human	0.90925342
88	ZNF263_19887448_ChIP-Seq_K562_Human	0.90775368
89	BCL6_27268052_Chip-Seq_Bcells_Human	0.90468280
90	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.89353502
91	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.88515592
92	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.88113975
93	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.87595279
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.86470618
95	SPI1_20517297_ChIP-Seq_HL60_Human	0.86226077
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.86111108
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.86098302
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.85557660
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.85557660
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.83860558

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	5.15509663
2	MP0003646_muscle_fatigue	3.89044623
3	MP0002102_abnormal_ear_morphology	3.80381754
4	MP0002138_abnormal_hepatobiliary_system	3.69352933
5	MP0000015_abnormal_ear_pigmentation	3.58151369
6	MP0004147_increased_porphyrin_level	3.57177697
7	MP0005377_hearing/vestibular/ear_phenot	3.24539414
8	MP0003878_abnormal_ear_physiology	3.24539414
9	MP0000372_irregular_coat_pigmentation	3.16008764
10	MP0004145_abnormal_muscle_electrophysio	3.15736695
11	MP0003011_delayed_dark_adaptation	2.84040834
12	MP0005167_abnormal_blood-brain_barrier	2.52964765
13	MP0003186_abnormal_redox_activity	2.48977293
14	MP0002095_abnormal_skin_pigmentation	2.48495213
15	MP0002736_abnormal_nociception_after	2.04145890
16	MP0001968_abnormal_touch/_nociception	1.91961134
17	MP0004885_abnormal_endolymph	1.82060528
18	MP0005075_abnormal_melanosome_morpholog	1.78297615
19	MP0008875_abnormal_xenobiotic_pharmacok	1.71306408
20	MP0002148_abnormal_hypersensitivity_rea	1.65471548
21	MP0003303_peritoneal_inflammation	1.61835321
22	MP0005397_hematopoietic_system_phenotyp	1.56309222
23	MP0001545_abnormal_hematopoietic_system	1.56309222
24	MP0001661_extended_life_span	1.55810669
25	MP0002837_dystrophic_cardiac_calcinosis	1.48726721
26	MP0006036_abnormal_mitochondrial_physio	1.46859135
27	MP0005670_abnormal_white_adipose	1.46738338
28	MP0006054_spinal_hemorrhage	1.46262921
29	MP0000371_diluted_coat_color	1.41321839
30	MP0004782_abnormal_surfactant_physiolog	1.35078488
31	MP0005671_abnormal_response_to	1.32106140
32	MP0009764_decreased_sensitivity_to	1.31280904
33	MP0003724_increased_susceptibility_to	1.25003395
34	MP0002332_abnormal_exercise_endurance	1.24596676
35	MP0005330_cardiomyopathy	1.23249596
36	MP0006072_abnormal_retinal_apoptosis	1.22560180
37	MP0010368_abnormal_lymphatic_system	1.22083974
38	MP0004233_abnormal_muscle_weight	1.19565873
39	MP0008872_abnormal_physiological_respon	1.16468458
40	MP0005083_abnormal_biliary_tract	1.14803591
41	MP0005084_abnormal_gallbladder_morpholo	1.14362087
42	MP0001324_abnormal_eye_pigmentation	1.14001928
43	MP0003828_pulmonary_edema	1.11866138
44	MP0009333_abnormal_splenocyte_physiolog	1.10213209
45	MP0005636_abnormal_mineral_homeostasis	1.06950956
46	MP0003718_maternal_effect	1.05118366
47	MP0003436_decreased_susceptibility_to	1.04008819
48	MP0003136_yellow_coat_color	1.01807009
49	MP0005464_abnormal_platelet_physiology	1.01457780
50	MP0004215_abnormal_myocardial_fiber	0.99635499
51	MP0008058_abnormal_DNA_repair	0.99441371
52	MP0000749_muscle_degeneration	0.98675546
53	MP0005379_endocrine/exocrine_gland_phen	0.97002148
54	MP0008775_abnormal_heart_ventricle	0.95230249
55	MP0004036_abnormal_muscle_relaxation	0.91717862
56	MP0009278_abnormal_bone_marrow	0.91660622
57	MP0005620_abnormal_muscle_contractility	0.91424528
58	MP0000230_abnormal_systemic_arterial	0.90280191
59	MP0003950_abnormal_plasma_membrane	0.88256035
60	MP0002269_muscular_atrophy	0.87006216
61	MP0009384_cardiac_valve_regurgitation	0.85440030
62	MP0008007_abnormal_cellular_replicative	0.84123065
63	MP0005253_abnormal_eye_physiology	0.83289876
64	MP0005551_abnormal_eye_electrophysiolog	0.83179469
65	MP0000343_altered_response_to	0.82908538
66	MP0001764_abnormal_homeostasis	0.82883020
67	MP0005389_reproductive_system_phenotype	0.81890831
68	MP0002972_abnormal_cardiac_muscle	0.81836819
69	MP0005319_abnormal_enzyme/_coenzyme	0.81703341
70	MP0001533_abnormal_skeleton_physiology	0.80866893
71	MP0004142_abnormal_muscle_tone	0.80388876
72	MP0003693_abnormal_embryo_hatching	0.79875460
73	MP0001879_abnormal_lymphatic_vessel	0.79627889
74	MP0003191_abnormal_cellular_cholesterol	0.78539918
75	MP0001544_abnormal_cardiovascular_syste	0.77749943
76	MP0005385_cardiovascular_system_phenoty	0.77749943
77	MP0002876_abnormal_thyroid_physiology	0.77147287
78	MP0006035_abnormal_mitochondrial_morpho	0.75132077
79	MP0005595_abnormal_vascular_smooth	0.72356112
80	MP0001873_stomach_inflammation	0.72305568
81	MP0001800_abnormal_humoral_immune	0.72186317
82	MP0005266_abnormal_metabolism	0.70954272
83	MP0005171_absent_coat_pigmentation	0.70356288
84	MP0005000_abnormal_immune_tolerance	0.69573226
85	MP0002723_abnormal_immune_serum	0.69249541
86	MP0000613_abnormal_salivary_gland	0.68954211
87	MP0005174_abnormal_tail_pigmentation	0.68064964
88	MP0005646_abnormal_pituitary_gland	0.66796017
89	MP0004957_abnormal_blastocyst_morpholog	0.65362899
90	MP0004130_abnormal_muscle_cell	0.65204895
91	MP0003195_calcinosis	0.62399080
92	MP0000465_gastrointestinal_hemorrhage	0.62353706
93	MP0006138_congestive_heart_failure	0.61444339
94	MP0002177_abnormal_outer_ear	0.61323474
95	MP0005410_abnormal_fertilization	0.61047024
96	MP0002452_abnormal_antigen_presenting	0.60823934
97	MP0006292_abnormal_olfactory_placode	0.60370758
98	MP0003567_abnormal_fetal_cardiomyocyte	0.59885554
99	MP0000538_abnormal_urinary_bladder	0.58590363
100	MP0009643_abnormal_urine_homeostasis	0.58172479

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal hemoglobin (HP:0011902)	5.92196242
2	Abnormality of the heme biosynthetic pathway (HP:0010472)	5.27032629
3	Acute necrotizing encephalopathy (HP:0006965)	5.10676794
4	Acute encephalopathy (HP:0006846)	4.48355085
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.45817014
6	Increased CSF lactate (HP:0002490)	4.33354917
7	Mitochondrial inheritance (HP:0001427)	4.32004353
8	Progressive macrocephaly (HP:0004481)	4.17018988
9	3-Methylglutaconic aciduria (HP:0003535)	4.14942955
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.98290837
11	Abnormality of cells of the erythroid lineage (HP:0012130)	3.90890423
12	Abnormal number of erythroid precursors (HP:0012131)	3.84829086
13	Hepatocellular necrosis (HP:0001404)	3.82812509
14	Cerebral edema (HP:0002181)	3.71837271
15	Congenital, generalized hypertrichosis (HP:0004540)	3.36340695
16	Hepatic necrosis (HP:0002605)	3.23690638
17	Pallor (HP:0000980)	3.17627872
18	Increased hepatocellular lipid droplets (HP:0006565)	3.11256710
19	Lipid accumulation in hepatocytes (HP:0006561)	3.05766420
20	Optic disc pallor (HP:0000543)	2.91623738
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.90417456
22	Lactic acidosis (HP:0003128)	2.86770173
23	Attenuation of retinal blood vessels (HP:0007843)	2.84527462
24	Increased serum lactate (HP:0002151)	2.79519175
25	Hematochezia (HP:0002573)	2.78418817
26	Respiratory failure (HP:0002878)	2.78265952
27	Albinism (HP:0001022)	2.73444605
28	Abnormality of alanine metabolism (HP:0010916)	2.73171961
29	Hyperalaninemia (HP:0003348)	2.73171961
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.73171961
31	Muscle fiber inclusion bodies (HP:0100299)	2.59533760
32	Nemaline bodies (HP:0003798)	2.53643464
33	Pancreatic cysts (HP:0001737)	2.47491879
34	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.46106516
35	Type II lissencephaly (HP:0007260)	2.44866243
36	True hermaphroditism (HP:0010459)	2.41696502
37	Myoglobinuria (HP:0002913)	2.36090879
38	Microcytic anemia (HP:0001935)	2.32916094
39	Renal Fanconi syndrome (HP:0001994)	2.32112365
40	Lethargy (HP:0001254)	2.31238200
41	Pancreatic fibrosis (HP:0100732)	2.29956647
42	Exercise intolerance (HP:0003546)	2.28894537
43	Abolished electroretinogram (ERG) (HP:0000550)	2.28474858
44	Prostate neoplasm (HP:0100787)	2.24183042
45	Anencephaly (HP:0002323)	2.23433892
46	Asymmetric septal hypertrophy (HP:0001670)	2.22810969
47	Abnormality of the prostate (HP:0008775)	2.22343095
48	Gastrointestinal infarctions (HP:0005244)	2.21790491
49	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.20441316
50	Rhabdomyolysis (HP:0003201)	2.19685710
51	Congenital stationary night blindness (HP:0007642)	2.18241846
52	Increased intramyocellular lipid droplets (HP:0012240)	2.16571254
53	Decreased central vision (HP:0007663)	2.16088211
54	Degeneration of anterior horn cells (HP:0002398)	2.13115855
55	Abnormality of the anterior horn cell (HP:0006802)	2.13115855
56	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.13044312
57	Type 2 muscle fiber atrophy (HP:0003554)	2.12972413
58	Hypertensive crisis (HP:0100735)	2.10113293
59	Tetany (HP:0001281)	2.07176536
60	Exertional dyspnea (HP:0002875)	2.06139906
61	Increased density of long bones (HP:0006392)	2.05605195
62	Abnormality of midbrain morphology (HP:0002418)	2.03027431
63	Molar tooth sign on MRI (HP:0002419)	2.03027431
64	Entropion (HP:0000621)	2.01281242
65	Congenital hepatic fibrosis (HP:0002612)	2.00597341
66	Pendular nystagmus (HP:0012043)	2.00039038
67	CNS demyelination (HP:0007305)	1.98146442
68	Severe muscular hypotonia (HP:0006829)	1.97145537
69	Homocystinuria (HP:0002156)	1.95472767
70	Abnormality of homocysteine metabolism (HP:0010919)	1.95472767
71	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.94236594
72	Rectal prolapse (HP:0002035)	1.93135149
73	Increased muscle lipid content (HP:0009058)	1.91783285
74	Leukodystrophy (HP:0002415)	1.89986716
75	Abnormality of the fovea (HP:0000493)	1.89582239
76	Abnormality of transition element cation homeostasis (HP:0011030)	1.87635237
77	Paralysis (HP:0003470)	1.87466430
78	Sclerocornea (HP:0000647)	1.84900250
79	Aplastic anemia (HP:0001915)	1.82135058
80	Pancytopenia (HP:0001876)	1.81977205
81	Abnormality of the renal cortex (HP:0011035)	1.79103997
82	Hypomagnesemia (HP:0002917)	1.78053853
83	Ocular albinism (HP:0001107)	1.76654679
84	Elevated erythrocyte sedimentation rate (HP:0003565)	1.76156380
85	Round ear (HP:0100830)	1.73370428
86	Cerebral hemorrhage (HP:0001342)	1.72185191
87	Blindness (HP:0000618)	1.69401198
88	Hypochromic anemia (HP:0001931)	1.69358504
89	Opisthotonus (HP:0002179)	1.69192553
90	Type I transferrin isoform profile (HP:0003642)	1.68340253
91	Microretrognathia (HP:0000308)	1.65668593
92	Increased corneal curvature (HP:0100692)	1.65487556
93	Keratoconus (HP:0000563)	1.65487556
94	X-linked dominant inheritance (HP:0001423)	1.64345848
95	Hypoplasia of the fovea (HP:0007750)	1.63680459
96	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.63680459
97	Biliary tract neoplasm (HP:0100574)	1.63433148
98	Vacuolated lymphocytes (HP:0001922)	1.61934800
99	Pulmonary fibrosis (HP:0002206)	1.61781107
100	Optic nerve coloboma (HP:0000588)	1.60757704

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	5.24767636
2	EIF2AK1	4.30849575
3	BCKDK	3.64120962
4	PDK2	3.07419378
5	EIF2AK3	2.83916019
6	NEK1	2.73720594
7	NUAK1	2.47434157
8	TGFBR2	2.13278736
9	OBSCN	2.01888878
10	NME2	2.01721983
11	PHKG2	2.00386030
12	PHKG1	2.00386030
13	MAP2K2	1.94568818
14	TRPM7	1.89936514
15	TESK2	1.85967424
16	FRK	1.84236090
17	VRK2	1.83128565
18	TGFBR1	1.79214902
19	TLK1	1.71889164
20	ADRBK2	1.66444341
21	ABL2	1.62495821
22	BMPR1B	1.48802346
23	GRK1	1.47816909
24	BMPR2	1.39911865
25	STK16	1.37469423
26	FES	1.37277601
27	PTK2B	1.28328986
28	TXK	1.22961464
29	ADRBK1	1.21703558
30	ZAK	1.18962452
31	KDR	1.17695833
32	BUB1	1.17124521
33	IKBKB	1.11194723
34	BRD4	1.09401443
35	MATK	1.04452845
36	PIM2	1.01820241
37	PLK2	1.01402274
38	PLK4	1.00378269
39	STK39	0.99465411
40	ACVR1B	0.98915605
41	MAP2K1	0.90396032
42	TEC	0.90377807
43	JAK3	0.90006680
44	STK3	0.83145443
45	MAP3K13	0.80422834
46	ERBB3	0.77641782
47	MAPKAPK5	0.76108014
48	GRK6	0.75903679
49	NEK2	0.74935694
50	TAF1	0.74785756
51	PLK3	0.74368076
52	SCYL2	0.73132192
53	PRKCQ	0.71821158
54	CDK8	0.71714854
55	GRK7	0.71485551
56	VRK1	0.68619772
57	FLT3	0.67835770
58	TAOK3	0.67018327
59	MOS	0.66136852
60	PAK2	0.66099370
61	CAMK1D	0.63931700
62	RPS6KA5	0.62483386
63	GRK5	0.62220472
64	SYK	0.61346375
65	EIF2AK2	0.61104500
66	PINK1	0.60721607
67	WNK4	0.60345966
68	OXSR1	0.58935579
69	CAMK2D	0.54160650
70	CDC42BPA	0.51037246
71	PKN1	0.50950155
72	TSSK6	0.50896393
73	INSRR	0.48309155
74	MAP4K2	0.47862088
75	KIT	0.47389704
76	PRKCD	0.46324654
77	IGF1R	0.44543674
78	RPS6KA6	0.43616983
79	DAPK3	0.42043386
80	SMG1	0.40364853
81	PASK	0.39583025
82	MKNK1	0.37927394
83	MAPK12	0.36878649
84	RPS6KC1	0.35017276
85	RPS6KL1	0.35017276
86	CDK9	0.33129707
87	CSNK2A2	0.32872806
88	CAMKK2	0.31515648
89	TTN	0.31514756
90	EGFR	0.31338066
91	EPHB2	0.30906309
92	CSNK2A1	0.30610499
93	PRKACA	0.30504702
94	PBK	0.30428395
95	PLK1	0.29957146
96	WEE1	0.29688188
97	PRKCA	0.28643200
98	CAMK2A	0.26794340
99	BMX	0.25713467
100	CSK	0.25095114

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.66554091
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.43525597
3	Proteasome_Homo sapiens_hsa03050	3.42146607
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.33741929
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.25813871
6	Parkinsons disease_Homo sapiens_hsa05012	3.15221651
7	One carbon pool by folate_Homo sapiens_hsa00670	2.46895014
8	RNA polymerase_Homo sapiens_hsa03020	2.26665741
9	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.17149999
10	Alzheimers disease_Homo sapiens_hsa05010	2.15284214
11	Huntingtons disease_Homo sapiens_hsa05016	2.05422822
12	Sulfur metabolism_Homo sapiens_hsa00920	2.01618709
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.95283058
14	Asthma_Homo sapiens_hsa05310	1.91827668
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.88383384
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.80855688
17	Protein export_Homo sapiens_hsa03060	1.78741491
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72129086
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.70711010
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63980937
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.63552985
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.54769734
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.52747224
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.52267436
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.49619115
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.49002857
27	Sulfur relay system_Homo sapiens_hsa04122	1.45225715
28	Phototransduction_Homo sapiens_hsa04744	1.40760555
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.38216964
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.35626241
31	Propanoate metabolism_Homo sapiens_hsa00640	1.35302907
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33449276
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.29359683
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.27160053
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.26608261
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24383755
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.23892844
38	RNA degradation_Homo sapiens_hsa03018	1.19669819
39	Basal transcription factors_Homo sapiens_hsa03022	1.14083213
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.13530348
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.13071510
42	Purine metabolism_Homo sapiens_hsa00230	1.11293761
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03195760
44	Glutathione metabolism_Homo sapiens_hsa00480	0.98910754
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98388834
46	Homologous recombination_Homo sapiens_hsa03440	0.98103915
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97374943
48	Peroxisome_Homo sapiens_hsa04146	0.97213492
49	Allograft rejection_Homo sapiens_hsa05330	0.95547389
50	Folate biosynthesis_Homo sapiens_hsa00790	0.95423878
51	Metabolic pathways_Homo sapiens_hsa01100	0.92784926
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.92161419
53	Base excision repair_Homo sapiens_hsa03410	0.88080525
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.87993120
55	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.87939266
56	Caffeine metabolism_Homo sapiens_hsa00232	0.86949228
57	RNA transport_Homo sapiens_hsa03013	0.83065065
58	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.81315610
59	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.79715879
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78468031
61	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.76478950
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75071722
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69616080
64	Mismatch repair_Homo sapiens_hsa03430	0.65661302
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.63431522
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61980475
67	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.61786593
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61684597
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60877607
70	Pentose phosphate pathway_Homo sapiens_hsa00030	0.60745519
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.59198783
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.56742526
73	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.55662837
74	Antigen processing and presentation_Homo sapiens_hsa04612	0.54111541
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53004582
76	Phenylalanine metabolism_Homo sapiens_hsa00360	0.52509130
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.52293482
78	p53 signaling pathway_Homo sapiens_hsa04115	0.51428450
79	Lysosome_Homo sapiens_hsa04142	0.51165720
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48838708
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.47599925
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.45700790
83	Malaria_Homo sapiens_hsa05144	0.44934381
84	DNA replication_Homo sapiens_hsa03030	0.43717759
85	Leishmaniasis_Homo sapiens_hsa05140	0.41451348
86	Retinol metabolism_Homo sapiens_hsa00830	0.41260088
87	ABC transporters_Homo sapiens_hsa02010	0.40393508
88	Type I diabetes mellitus_Homo sapiens_hsa04940	0.40333984
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.39296533
90	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.37295217
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.32813344
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.32761946
93	Serotonergic synapse_Homo sapiens_hsa04726	0.32606498
94	Mineral absorption_Homo sapiens_hsa04978	0.28832387
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.28328638
96	Non-homologous end-joining_Homo sapiens_hsa03450	0.27619769
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.25015977
98	Carbon metabolism_Homo sapiens_hsa01200	0.24626743
99	Butanoate metabolism_Homo sapiens_hsa00650	0.23890101
100	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.23594323

PSMD4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »