PSMD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.45830543
2DNA strand elongation involved in DNA replication (GO:0006271)4.83690966
3DNA replication initiation (GO:0006270)4.83255361
4telomere maintenance via semi-conservative replication (GO:0032201)4.62420156
5DNA strand elongation (GO:0022616)4.61644886
6nucleobase biosynthetic process (GO:0046112)4.39452897
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.32373262
8DNA deamination (GO:0045006)4.31468894
9CENP-A containing nucleosome assembly (GO:0034080)4.30241709
10DNA unwinding involved in DNA replication (GO:0006268)4.28369533
11chromatin remodeling at centromere (GO:0031055)4.21931667
12purine nucleobase biosynthetic process (GO:0009113)4.21445047
13DNA replication checkpoint (GO:0000076)4.20129496
14mitotic metaphase plate congression (GO:0007080)4.14365716
15pore complex assembly (GO:0046931)4.12424423
16telomere maintenance via recombination (GO:0000722)4.05164072
17IMP biosynthetic process (GO:0006188)4.03344101
18formation of translation preinitiation complex (GO:0001731)3.97435933
19regulation of translational fidelity (GO:0006450)3.87395573
20telomere maintenance via telomere lengthening (GO:0010833)3.84754833
21sister chromatid segregation (GO:0000819)3.83256356
22tRNA aminoacylation for protein translation (GO:0006418)3.81821463
23mitotic recombination (GO:0006312)3.80253139
24protein localization to kinetochore (GO:0034501)3.79381415
25amino acid activation (GO:0043038)3.75314480
26tRNA aminoacylation (GO:0043039)3.75314480
27DNA replication-independent nucleosome organization (GO:0034724)3.72420195
28DNA replication-independent nucleosome assembly (GO:0006336)3.72420195
29DNA topological change (GO:0006265)3.71920354
30cullin deneddylation (GO:0010388)3.71711864
31protein deneddylation (GO:0000338)3.71589216
32kinetochore organization (GO:0051383)3.70533352
33ribosome biogenesis (GO:0042254)3.69403229
34folic acid-containing compound biosynthetic process (GO:0009396)3.68783142
35ribosomal small subunit assembly (GO:0000028)3.68752934
36maturation of SSU-rRNA (GO:0030490)3.68514817
37* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67502046
38metaphase plate congression (GO:0051310)3.66976604
39establishment of integrated proviral latency (GO:0075713)3.66716875
40* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.63671543
41DNA replication-dependent nucleosome organization (GO:0034723)3.63037166
42DNA replication-dependent nucleosome assembly (GO:0006335)3.63037166
43mitotic nuclear envelope disassembly (GO:0007077)3.62575102
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.61210621
45* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60457286
46* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57207124
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.56695969
48* proteasome assembly (GO:0043248)3.56265832
49IMP metabolic process (GO:0046040)3.54792098
50regulation of mitotic spindle organization (GO:0060236)3.50614974
51attachment of spindle microtubules to kinetochore (GO:0008608)3.48208462
52ribosome assembly (GO:0042255)3.47282563
53ribosomal large subunit biogenesis (GO:0042273)3.46784824
54kinetochore assembly (GO:0051382)3.45112508
55rRNA modification (GO:0000154)3.45090304
56maturation of 5.8S rRNA (GO:0000460)3.44640851
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.42446931
58negative regulation of sister chromatid segregation (GO:0033046)3.42446931
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.42446931
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.42446931
61mitotic spindle assembly checkpoint (GO:0007094)3.41066528
62regulation of centriole replication (GO:0046599)3.41047768
63spindle assembly checkpoint (GO:0071173)3.40753636
64establishment of chromosome localization (GO:0051303)3.38894867
65deoxyribonucleotide biosynthetic process (GO:0009263)3.37832258
66COPI coating of Golgi vesicle (GO:0048205)3.36353784
67Golgi transport vesicle coating (GO:0048200)3.36353784
68negative regulation of chromosome segregation (GO:0051985)3.36312893
69membrane disassembly (GO:0030397)3.36205910
70nuclear envelope disassembly (GO:0051081)3.36205910
71histone exchange (GO:0043486)3.35747320
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33915664
73pseudouridine synthesis (GO:0001522)3.33641273
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32356378
75* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31156389
76* negative regulation of ligase activity (GO:0051352)3.31156389
77spindle checkpoint (GO:0031577)3.30756507
78ribonucleoprotein complex biogenesis (GO:0022613)3.29321591
79regulation of double-strand break repair via homologous recombination (GO:0010569)3.27571750
80transcription-coupled nucleotide-excision repair (GO:0006283)3.26885092
81* cell cycle G1/S phase transition (GO:0044843)3.26816258
82* G1/S transition of mitotic cell cycle (GO:0000082)3.26816258
83RNA-dependent DNA replication (GO:0006278)3.26236210
84mitotic spindle checkpoint (GO:0071174)3.22925841
85viral mRNA export from host cell nucleus (GO:0046784)3.21798018
86intra-S DNA damage checkpoint (GO:0031573)3.20700482
87meiotic chromosome segregation (GO:0045132)3.20527165
88rRNA processing (GO:0006364)3.16221705
89* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15530900
90protein localization to chromosome, centromeric region (GO:0071459)3.15380106
91mitotic sister chromatid segregation (GO:0000070)3.14248347
92mitotic chromosome condensation (GO:0007076)3.12888415
93spliceosomal snRNP assembly (GO:0000387)3.12281155
94regulation of chromosome segregation (GO:0051983)3.11826466
95synapsis (GO:0007129)3.11256147
96postreplication repair (GO:0006301)3.11141531
97rRNA methylation (GO:0031167)3.09987025
98telomere maintenance via telomerase (GO:0007004)3.09797883
99regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08287186
100nuclear pore organization (GO:0006999)3.07078607
101regulation of spindle organization (GO:0090224)3.06025499
102* positive regulation of ligase activity (GO:0051351)3.04495554
103regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.04248835
104rRNA metabolic process (GO:0016072)3.04164721
105DNA ligation (GO:0006266)3.03017601
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02471201
107somatic hypermutation of immunoglobulin genes (GO:0016446)3.02018768
108somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02018768
109* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01380159
110telomere organization (GO:0032200)3.00559970
111telomere maintenance (GO:0000723)3.00500204
1127-methylguanosine mRNA capping (GO:0006370)2.99292846
113mitotic sister chromatid cohesion (GO:0007064)2.98651847
114COPII vesicle coating (GO:0048208)2.98057804
115* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97706403
116* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97706403
117transcription elongation from RNA polymerase III promoter (GO:0006385)2.97300119
118termination of RNA polymerase III transcription (GO:0006386)2.97300119
119* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96247561
120* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96247561
121* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96247561
122non-recombinational repair (GO:0000726)2.96126865
123double-strand break repair via nonhomologous end joining (GO:0006303)2.96126865
124regulation of translational elongation (GO:0006448)2.94771843
125chromosome segregation (GO:0007059)2.94580650
126DNA catabolic process, exonucleolytic (GO:0000738)2.93920464
127resolution of meiotic recombination intermediates (GO:0000712)2.91809384
128UDP-N-acetylglucosamine metabolic process (GO:0006047)2.89897346
129DNA double-strand break processing (GO:0000729)2.89788782
130mitochondrial DNA replication (GO:0006264)2.89360783
131nuclear envelope organization (GO:0006998)2.87937254
132regulation of histone H3-K27 methylation (GO:0061085)2.86866142
133mitochondrial RNA metabolic process (GO:0000959)2.82226554
134* regulation of ubiquitin-protein transferase activity (GO:0051438)2.82176957
135pteridine-containing compound biosynthetic process (GO:0042559)2.81184741
136regulation of sister chromatid segregation (GO:0033045)2.76960700
137regulation of mitotic sister chromatid separation (GO:0010965)2.76960700
138regulation of mitotic sister chromatid segregation (GO:0033047)2.76960700
139* regulation of ligase activity (GO:0051340)2.74599482
140iron ion import (GO:0097286)2.71241042
141regulation of centrosome cycle (GO:0046605)2.70019579
142AMP metabolic process (GO:0046033)2.69633936
143nucleotide-sugar biosynthetic process (GO:0009226)2.69493539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.30040776
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.42666879
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84508985
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82530354
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73378290
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.51953774
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.33131624
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29732947
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.24497645
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05979747
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96005699
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.94038006
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88330381
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86952081
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86644190
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75497530
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75408323
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.70292165
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.65628996
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.57822190
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54107138
22* VDR_23849224_ChIP-Seq_CD4+_Human2.46865118
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36861132
24XRN2_22483619_ChIP-Seq_HELA_Human2.32393298
25DCP1A_22483619_ChIP-Seq_HELA_Human2.29389947
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28967021
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28690868
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27212414
29AR_21909140_ChIP-Seq_LNCAP_Human2.25867009
30FOXP3_21729870_ChIP-Seq_TREG_Human2.17599449
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16804784
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08373286
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05420617
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05231962
35GABP_19822575_ChIP-Seq_HepG2_Human2.03675402
36* E2F1_21310950_ChIP-Seq_MCF-7_Human2.03271225
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.99632742
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.98099688
39* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95436586
40ELK1_19687146_ChIP-ChIP_HELA_Human1.94437919
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91476188
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91302079
43TTF2_22483619_ChIP-Seq_HELA_Human1.83425342
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82393115
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79391722
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.78904891
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78476172
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76629980
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68093593
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67967842
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.67245787
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61646185
53GATA1_22025678_ChIP-Seq_K562_Human1.59428364
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59178999
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56072835
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50562603
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49823344
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.48728152
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48701893
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48602203
61CIITA_25753668_ChIP-Seq_RAJI_Human1.44933063
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44163002
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41935886
64KDM5A_27292631_Chip-Seq_BREAST_Human1.35330967
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33742110
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.31461535
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30849001
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28076629
69TFEB_21752829_ChIP-Seq_HELA_Human1.26267022
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24176339
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.22154442
72ZNF263_19887448_ChIP-Seq_K562_Human1.22120871
73MYC_18940864_ChIP-ChIP_HL60_Human1.21650280
74ELF5_23300383_ChIP-Seq_T47D_Human1.20540270
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13412693
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10655125
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10108854
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09699918
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06963594
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05483104
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04759443
82BRD4_25478319_ChIP-Seq_HGPS_Human1.04142068
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02054566
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.00889526
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00727891
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99161232
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98924823
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97490999
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96981776
90HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96886685
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95397703
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94264528
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91975551
94SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90913775
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89557620
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89538301
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89290832
98EWS_26573619_Chip-Seq_HEK293_Human0.89284248
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88707933
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88707933
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88624138
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88288387
103CHD1_26751641_Chip-Seq_LNCaP_Human0.87043241
104GATA4_21415370_ChIP-Seq_HL-1_Mouse0.86987115
105VDR_22108803_ChIP-Seq_LS180_Human0.85659757
106SPI1_23547873_ChIP-Seq_NB4_Human0.83838186
107* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82525346
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82321603
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81408417
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.81119758
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80469545
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80447671
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80279622
114MYC_22102868_ChIP-Seq_BL_Human0.79828759
115FUS_26573619_Chip-Seq_HEK293_Human0.79728915
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79574785
117* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76779364
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76328710
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76286945
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76284695
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75142523
122CLOCK_20551151_ChIP-Seq_293T_Human0.74774127
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.74339173
124NANOG_16153702_ChIP-ChIP_HESCs_Human0.72549553
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71415710
126FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70653558
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70198702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.20589986
2MP0010094_abnormal_chromosome_stability5.14315044
3MP0003111_abnormal_nucleus_morphology4.49613922
4MP0004957_abnormal_blastocyst_morpholog4.31289009
5MP0008058_abnormal_DNA_repair4.09837189
6MP0003077_abnormal_cell_cycle4.09041504
7MP0003950_abnormal_plasma_membrane3.88805594
8MP0008057_abnormal_DNA_replication3.74348773
9MP0008007_abnormal_cellular_replicative3.38959450
10MP0002396_abnormal_hematopoietic_system3.18117653
11MP0003123_paternal_imprinting2.98779766
12MP0008932_abnormal_embryonic_tissue2.90486233
13MP0008995_early_reproductive_senescence2.76078875
14MP0003786_premature_aging2.30323486
15MP0002877_abnormal_melanocyte_morpholog2.19799176
16MP0003806_abnormal_nucleotide_metabolis2.17247333
17MP0009697_abnormal_copulation2.09899929
18MP0000350_abnormal_cell_proliferation2.06768994
19MP0008438_abnormal_cutaneous_collagen2.03122261
20MP0003718_maternal_effect2.01136287
21MP0010234_abnormal_vibrissa_follicle2.00714307
22MP0002796_impaired_skin_barrier1.97459242
23MP0004147_increased_porphyrin_level1.97419949
24MP0001730_embryonic_growth_arrest1.94738851
25MP0010352_gastrointestinal_tract_polyps1.84781229
26MP0008877_abnormal_DNA_methylation1.82889883
27MP0004272_abnormal_basement_membrane1.75275980
28MP0000490_abnormal_crypts_of1.68112477
29MP0010030_abnormal_orbit_morphology1.64017875
30MP0003186_abnormal_redox_activity1.58567330
31MP0002254_reproductive_system_inflammat1.48935163
32MP0002210_abnormal_sex_determination1.48062102
33MP0002019_abnormal_tumor_incidence1.47449653
34MP0005275_abnormal_skin_tensile1.45842206
35MP0002160_abnormal_reproductive_system1.45699319
36MP0003656_abnormal_erythrocyte_physiolo1.45325690
37MP0003566_abnormal_cell_adhesion1.44848415
38MP0001697_abnormal_embryo_size1.41267106
39MP0005501_abnormal_skin_physiology1.40623892
40MP0003121_genomic_imprinting1.39226554
41MP0000313_abnormal_cell_death1.37765102
42MP0004233_abnormal_muscle_weight1.37691571
43MP0002080_prenatal_lethality1.37282748
44MP0004808_abnormal_hematopoietic_stem1.36120316
45MP0001545_abnormal_hematopoietic_system1.33825398
46MP0005397_hematopoietic_system_phenotyp1.33825398
47MP0001119_abnormal_female_reproductive1.32880790
48MP0010307_abnormal_tumor_latency1.32006606
49MP0005389_reproductive_system_phenotype1.31235519
50MP0005451_abnormal_body_composition1.27377278
51MP0002060_abnormal_skin_morphology1.26569527
52MP0005408_hypopigmentation1.26263716
53MP0001145_abnormal_male_reproductive1.25024208
54MP0001672_abnormal_embryogenesis/_devel1.22298583
55MP0005380_embryogenesis_phenotype1.22298583
56MP0006292_abnormal_olfactory_placode1.21316679
57MP0002132_abnormal_respiratory_system1.21098007
58MP0001216_abnormal_epidermal_layer1.20320266
59MP0009379_abnormal_foot_pigmentation1.18823478
60MP0000653_abnormal_sex_gland1.18567759
61MP0000647_abnormal_sebaceous_gland1.18261269
62MP0001188_hyperpigmentation1.16695934
63MP0003705_abnormal_hypodermis_morpholog1.15630055
64MP0009333_abnormal_splenocyte_physiolog1.15603692
65MP0001919_abnormal_reproductive_system1.15400322
66MP0002085_abnormal_embryonic_tissue1.15358803
67MP0003315_abnormal_perineum_morphology1.13045993
68MP0002938_white_spotting1.12421706
69MP0001881_abnormal_mammary_gland1.11905196
70MP0003941_abnormal_skin_development1.10393192
71MP0001661_extended_life_span1.10122285
72MP0005395_other_phenotype1.09854833
73MP0000566_synostosis1.09013654
74MP0000858_altered_metastatic_potential1.06685803
75MP0001243_abnormal_dermal_layer1.06288966
76MP0009780_abnormal_chondrocyte_physiolo1.04110008
77MP0003984_embryonic_growth_retardation1.03068055
78MP0000427_abnormal_hair_cycle1.00842971
79MP0010678_abnormal_skin_adnexa1.00520350
80MP0001929_abnormal_gametogenesis1.00175785
81MP0003942_abnormal_urinary_system0.99437866
82MP0000358_abnormal_cell_content/0.99421251
83MP0009053_abnormal_anal_canal0.99053906
84MP0002095_abnormal_skin_pigmentation0.98783602
85MP0002088_abnormal_embryonic_growth/wei0.97497030
86MP0000613_abnormal_salivary_gland0.96511829
87MP0001727_abnormal_embryo_implantation0.95393050
88MP0000627_abnormal_mammary_gland0.94287728
89MP0003763_abnormal_thymus_physiology0.91499374
90MP0002084_abnormal_developmental_patter0.91335817
91MP0001764_abnormal_homeostasis0.90920903
92MP0006054_spinal_hemorrhage0.90638789
93MP0002086_abnormal_extraembryonic_tissu0.89250737
94MP0001191_abnormal_skin_condition0.88099372
95MP0002398_abnormal_bone_marrow0.87542523
96MP0004197_abnormal_fetal_growth/weight/0.85229708
97MP0006036_abnormal_mitochondrial_physio0.85120127
98MP0001293_anophthalmia0.84658812
99MP0001299_abnormal_eye_distance/0.84233496
100MP0000703_abnormal_thymus_morphology0.83719931
101MP0000689_abnormal_spleen_morphology0.83423730
102MP0004782_abnormal_surfactant_physiolog0.82845192
103MP0005384_cellular_phenotype0.82664866
104MP0002722_abnormal_immune_system0.82200392
105MP0005083_abnormal_biliary_tract0.80475811
106MP0005257_abnormal_intraocular_pressure0.79138028
107MP0009703_decreased_birth_body0.78391568
108MP0003943_abnormal_hepatobiliary_system0.76682077
109MP0000377_abnormal_hair_follicle0.74925619
110MP0005075_abnormal_melanosome_morpholog0.74913799
111MP0006035_abnormal_mitochondrial_morpho0.74867225
112MP0002295_abnormal_pulmonary_circulatio0.74586897
113MP0010771_integument_phenotype0.73210778
114MP0002429_abnormal_blood_cell0.72204479
115MP0000428_abnormal_craniofacial_morphol0.72023414
116MP0003890_abnormal_embryonic-extraembry0.71012704
117MP0008260_abnormal_autophagy0.70963865
118MP0005621_abnormal_cell_physiology0.70925512
119MP0000383_abnormal_hair_follicle0.68483398
120MP0003453_abnormal_keratinocyte_physiol0.66952479
121MP0009931_abnormal_skin_appearance0.66799568
122MP0003699_abnormal_female_reproductive0.66623614
123MP0005266_abnormal_metabolism0.66052426
124MP0001915_intracranial_hemorrhage0.65890083
125MP0003385_abnormal_body_wall0.65002035
126MP0000015_abnormal_ear_pigmentation0.64791195
127MP0002102_abnormal_ear_morphology0.64060754
128MP0003868_abnormal_feces_composition0.63773758
129MP0000467_abnormal_esophagus_morphology0.63720305
130MP0002111_abnormal_tail_morphology0.62372820
131MP0002269_muscular_atrophy0.61689032
132MP0003221_abnormal_cardiomyocyte_apopto0.59165337
133MP0004133_heterotaxia0.59080073
134MP0003937_abnormal_limbs/digits/tail_de0.58710107
135MP0005023_abnormal_wound_healing0.58297039
136MP0001853_heart_inflammation0.57055177
137MP0000477_abnormal_intestine_morphology0.56420604
138MP0000681_abnormal_thyroid_gland0.54854264
139MP0002075_abnormal_coat/hair_pigmentati0.54074418
140MP0009250_abnormal_appendicular_skeleto0.53943697
141MP0001186_pigmentation_phenotype0.53070048
142MP0009672_abnormal_birth_weight0.52532072
143MP0003936_abnormal_reproductive_system0.52220052
144MP0002751_abnormal_autonomic_nervous0.51955230
145MP0001529_abnormal_vocalization0.51485655
146MP0003567_abnormal_fetal_cardiomyocyte0.51195100

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.21614656
2Chromsome breakage (HP:0040012)3.93269449
3Aplastic anemia (HP:0001915)3.78014723
4Reticulocytopenia (HP:0001896)3.65423608
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57796831
6Abnormality of methionine metabolism (HP:0010901)3.52479823
7Colon cancer (HP:0003003)3.43488483
8Oral leukoplakia (HP:0002745)3.42056486
9Breast hypoplasia (HP:0003187)3.41973451
10Short middle phalanx of the 5th finger (HP:0004220)3.40597845
11Cholecystitis (HP:0001082)3.39910402
12Abnormal gallbladder physiology (HP:0012438)3.39910402
13Meckel diverticulum (HP:0002245)3.26203118
14Patellar aplasia (HP:0006443)3.21110196
15Abnormality of the preputium (HP:0100587)3.14827957
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.14130213
17Cerebral hypomyelination (HP:0006808)3.14116734
18Abnormality of chromosome stability (HP:0003220)3.12436302
19Agnosia (HP:0010524)3.10638319
20Abnormality of the ileum (HP:0001549)3.07058230
21Medulloblastoma (HP:0002885)3.01634837
22Abnormality of the anterior horn cell (HP:0006802)3.01150588
23Degeneration of anterior horn cells (HP:0002398)3.01150588
24Abnormal number of erythroid precursors (HP:0012131)3.00171885
25Aplasia/Hypoplasia of the patella (HP:0006498)2.95651307
26Type I transferrin isoform profile (HP:0003642)2.94736887
27Ankyloglossia (HP:0010296)2.93891918
28Rough bone trabeculation (HP:0100670)2.88603606
29Abnormality of cells of the erythroid lineage (HP:0012130)2.81391281
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.78992265
31Carpal bone hypoplasia (HP:0001498)2.76017534
32Duplicated collecting system (HP:0000081)2.71136450
33Abnormal lung lobation (HP:0002101)2.67279037
34Microretrognathia (HP:0000308)2.65241619
35Myelodysplasia (HP:0002863)2.64886162
36Bone marrow hypocellularity (HP:0005528)2.58663029
37Small intestinal stenosis (HP:0012848)2.55706288
38Duodenal stenosis (HP:0100867)2.55706288
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54301870
40Abnormality of the labia minora (HP:0012880)2.52681016
41Reduced antithrombin III activity (HP:0001976)2.50567210
42Abnormal glycosylation (HP:0012345)2.48285851
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.48285851
44Abnormal protein N-linked glycosylation (HP:0012347)2.48285851
45Abnormal protein glycosylation (HP:0012346)2.48285851
46Sloping forehead (HP:0000340)2.45284861
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44342725
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44342725
49Increased serum lactate (HP:0002151)2.41956590
50Hypoglycemic coma (HP:0001325)2.41128963
51Premature graying of hair (HP:0002216)2.40727550
52Adenoma sebaceum (HP:0009720)2.35031678
53Angiofibromas (HP:0010615)2.35031678
54Absent thumb (HP:0009777)2.34706057
5511 pairs of ribs (HP:0000878)2.33559993
56Abnormality of alanine metabolism (HP:0010916)2.33303715
57Hyperalaninemia (HP:0003348)2.33303715
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33303715
59Acute myeloid leukemia (HP:0004808)2.32918591
60Biliary tract neoplasm (HP:0100574)2.29949709
61Abnormality of oral frenula (HP:0000190)2.29421881
62Microglossia (HP:0000171)2.29303321
63Rhabdomyosarcoma (HP:0002859)2.28620805
64Homocystinuria (HP:0002156)2.26738291
65Abnormality of homocysteine metabolism (HP:0010919)2.26738291
66Neoplasm of the pancreas (HP:0002894)2.25699341
67Abnormal trabecular bone morphology (HP:0100671)2.24758039
68Abnormality of DNA repair (HP:0003254)2.24017129
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23984562
70Upper limb muscle weakness (HP:0003484)2.22803447
71Cortical dysplasia (HP:0002539)2.22699016
72Pallor (HP:0000980)2.22505124
73Hepatocellular necrosis (HP:0001404)2.20772301
74Microvesicular hepatic steatosis (HP:0001414)2.19842063
75Horseshoe kidney (HP:0000085)2.19841434
76Selective tooth agenesis (HP:0001592)2.19596002
77Triphalangeal thumb (HP:0001199)2.18169160
78Glioma (HP:0009733)2.16765304
79Deep philtrum (HP:0002002)2.15716610
80Hypoplastic labia majora (HP:0000059)2.15641621
81CNS hypomyelination (HP:0003429)2.13865276
82Pancytopenia (HP:0001876)2.13439622
83Abnormality of the duodenum (HP:0002246)2.12438149
84Secondary amenorrhea (HP:0000869)2.12391657
85Increased hepatocellular lipid droplets (HP:0006565)2.10498097
86Abnormality of pyrimidine metabolism (HP:0004353)2.10376840
87Abnormality of the carotid arteries (HP:0005344)2.09645712
88Sparse eyelashes (HP:0000653)2.09565451
89Cafe-au-lait spot (HP:0000957)2.09309210
90Macrocytic anemia (HP:0001972)2.07604633
91Abnormality of the renal collecting system (HP:0004742)2.06845485
92Embryonal renal neoplasm (HP:0011794)2.06732297
93Nephroblastoma (Wilms tumor) (HP:0002667)2.06480772
94Curly hair (HP:0002212)2.02850755
95Increased nuchal translucency (HP:0010880)2.02783064
96Astrocytoma (HP:0009592)2.01034382
97Abnormality of the astrocytes (HP:0100707)2.01034382
98Type 2 muscle fiber atrophy (HP:0003554)1.99620322
99Abnormal spermatogenesis (HP:0008669)1.99560726
100Unsteady gait (HP:0002317)1.99398049
101Acute encephalopathy (HP:0006846)1.98484227
102Premature ovarian failure (HP:0008209)1.98372662
103True hermaphroditism (HP:0010459)1.97336877
104Supernumerary spleens (HP:0009799)1.96731793
105Neoplasm of the rectum (HP:0100743)1.96565787
106Slender long bone (HP:0003100)1.96348520
107Absent radius (HP:0003974)1.95903069
108Entropion (HP:0000621)1.95533166
109Hepatic necrosis (HP:0002605)1.93330788
110Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93209480
111Abnormality of sulfur amino acid metabolism (HP:0004339)1.92525502
112Ependymoma (HP:0002888)1.91894375
113Increased serum pyruvate (HP:0003542)1.90266473
114Abnormality of glycolysis (HP:0004366)1.90266473
115Muscle fiber atrophy (HP:0100295)1.89603052
116Conjunctival hamartoma (HP:0100780)1.89578046
117Tetraparesis (HP:0002273)1.89379494
118Ectopic kidney (HP:0000086)1.89035617
119Impulsivity (HP:0100710)1.88558599
120Megaloblastic anemia (HP:0001889)1.87169024
121Neoplasm of the colon (HP:0100273)1.87132777
122Papillary thyroid carcinoma (HP:0002895)1.86857948
123Clubbing of toes (HP:0100760)1.86297467
124Atresia of the external auditory canal (HP:0000413)1.85569937
125Facial hemangioma (HP:0000329)1.85019747
126Neoplasm of the small intestine (HP:0100833)1.83737894
127Abnormality of the labia majora (HP:0012881)1.83420961
128Ovarian neoplasm (HP:0100615)1.82457957
129Symptomatic seizures (HP:0011145)1.82092669
130Onycholysis (HP:0001806)1.81384487
131Atrophy/Degeneration involving motor neurons (HP:0007373)1.81380213
132Median cleft lip (HP:0000161)1.80894057
133Irregular epiphyses (HP:0010582)1.80412445
134Premature rupture of membranes (HP:0001788)1.79991725
135Aplasia involving forearm bones (HP:0009822)1.79816646
136Absent forearm bone (HP:0003953)1.79816646
137Stenosis of the external auditory canal (HP:0000402)1.79247534
138Hypoglycemic seizures (HP:0002173)1.78919571
139Orthostatic hypotension (HP:0001278)1.78451456
140Self-mutilation (HP:0000742)1.78432342
141Amaurosis fugax (HP:0100576)1.78238748
142Pancreatic cysts (HP:0001737)1.78184916
143Capillary hemangiomas (HP:0005306)1.77899628
144Optic nerve coloboma (HP:0000588)1.77788156
145Postnatal microcephaly (HP:0005484)1.77760959
146Increased CSF lactate (HP:0002490)1.77644120
147Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77583021
148Abnormality of serum amino acid levels (HP:0003112)1.77417765
149Ureteral duplication (HP:0000073)1.76373482
150Lipid accumulation in hepatocytes (HP:0006561)1.75102303
151Squamous cell carcinoma (HP:0002860)1.73414454
152Choanal atresia (HP:0000453)1.71946155
153Overlapping toe (HP:0001845)1.71795175
154Congenital ichthyosiform erythroderma (HP:0007431)1.69778843
155Breech presentation (HP:0001623)1.68429809
156Abnormality of reticulocytes (HP:0004312)1.68044122
157Arteriovenous malformation (HP:0100026)1.66735340
158Thyroid carcinoma (HP:0002890)1.66380044
159Breast carcinoma (HP:0003002)1.66025923
160Reticulocytosis (HP:0001923)1.64509371
161Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.61113258
162Trismus (HP:0000211)1.59198647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.80067529
2EIF2AK14.15511210
3WEE13.80248243
4CDC73.55012043
5MST43.22305663
6STK162.95812829
7ACVR1B2.88918166
8BRSK22.81369907
9SRPK12.61322481
10TRIM282.44596492
11TESK22.35577961
12EIF2AK32.23407355
13TLK12.21764279
14MST1R2.20066066
15NME22.16623462
16NEK12.13806349
17VRK12.13683766
18NEK21.98844166
19TSSK61.94668641
20PLK11.88914776
21BRSK11.87649707
22PASK1.84888342
23TTK1.84883218
24PDK21.77341442
25MKNK11.70647070
26PLK31.64839707
27PLK41.63950700
28ATR1.58723654
29RPS6KA41.47182149
30PBK1.43360854
31CDK71.41276326
32FLT31.40282964
33BRD41.38255202
34AURKB1.37902245
35AURKA1.37455493
36PIM21.33763542
37ZAK1.33436796
38MAP3K21.31345650
39SCYL21.30611885
40TGFBR11.30070324
41MET1.27178443
42BRAF1.23027354
43CDK81.22184754
44CCNB11.21608881
45CHEK21.19698993
46NME11.18940391
47TESK11.15847059
48RPS6KB21.15625086
49MKNK21.15253760
50ERBB41.12743519
51STK38L1.10594638
52DYRK31.05680683
53LIMK11.02278868
54MAP3K81.00785443
55EIF2AK20.99873059
56NEK90.93735922
57KSR10.93512004
58TNIK0.92966161
59LATS10.90680701
60TAOK20.87131306
61TIE10.85593338
62KDR0.84504383
63CHEK10.82034899
64BMPR20.81858663
65VRK20.79377171
66FGFR10.77907511
67STK100.77881703
68PAK40.73222245
69TRPM70.71879133
70CDK40.71506617
71TGFBR20.71106876
72EPHA20.70844642
73MAP3K110.70672785
74ATM0.69743240
75MAPKAPK30.69107104
76STK40.67671554
77PLK20.67232440
78FER0.66956282
79TAF10.65727926
80CSNK2A10.65721297
81SIK30.64864748
82BCKDK0.61265119
83CSNK2A20.60870543
84IRAK30.57610036
85MELK0.57588170
86TEC0.56264292
87PTK20.54991201
88KSR20.54487736
89CDK20.54087084
90ALK0.53912083
91PAK10.51170076
92PAK20.50518545
93MAP3K120.50494846
94PIM10.49306667
95NUAK10.48078844
96WNK40.48016937
97CDK10.46202024
98MYLK0.43447177
99MAPKAPK50.42512213
100ERBB30.42277380
101MAP4K20.41624093
102MAP3K50.40307143
103CDK190.40008341
104STK390.39902248
105RPS6KA50.39491597
106DYRK20.35677464
107YES10.34065342
108PRKCI0.33324095
109STK240.33031154
110KIT0.32875879
111STK30.32571332
112PDGFRA0.30105084
113PIK3CG0.29895766
114CSNK1E0.29786485
115FRK0.29463180
116CSNK1G30.29172327
117BTK0.28913646
118ABL20.28898029
119ARAF0.28668868
120MAP3K100.28523109
121PRKCE0.27061826
122MAP2K10.26887673
123RAF10.26538155
124CLK10.26468599
125MAP2K30.26192893
126MAPK110.25586999
127ZAP700.23792511
128EEF2K0.23543325
129LATS20.20981728
130LYN0.19585591
131AKT30.19536599
132BCR0.19154949
133CDK140.17570172
134DAPK10.17032123
135TXK0.16450006
136PRKDC0.16192362

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.01333969
2Mismatch repair_Homo sapiens_hsa034304.22717345
3Proteasome_Homo sapiens_hsa030503.74633299
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56172619
5Homologous recombination_Homo sapiens_hsa034403.29148860
6Base excision repair_Homo sapiens_hsa034103.24177945
7RNA polymerase_Homo sapiens_hsa030203.17811598
8Nucleotide excision repair_Homo sapiens_hsa034203.04993901
9Spliceosome_Homo sapiens_hsa030402.89334193
10Cell cycle_Homo sapiens_hsa041102.86574137
11RNA transport_Homo sapiens_hsa030132.83586799
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.83558803
13Ribosome_Homo sapiens_hsa030102.79941117
14One carbon pool by folate_Homo sapiens_hsa006702.77786198
15Pyrimidine metabolism_Homo sapiens_hsa002402.66734778
16Non-homologous end-joining_Homo sapiens_hsa034502.33498336
17Fanconi anemia pathway_Homo sapiens_hsa034602.32177352
18Basal transcription factors_Homo sapiens_hsa030222.06403602
19Steroid biosynthesis_Homo sapiens_hsa001002.02661095
20RNA degradation_Homo sapiens_hsa030181.93136804
21Propanoate metabolism_Homo sapiens_hsa006401.88991108
22Fatty acid elongation_Homo sapiens_hsa000621.70115560
23Protein export_Homo sapiens_hsa030601.55330385
24p53 signaling pathway_Homo sapiens_hsa041151.55228962
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51659868
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48009788
27Purine metabolism_Homo sapiens_hsa002301.44217614
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43682249
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36449839
30mRNA surveillance pathway_Homo sapiens_hsa030151.29933666
31Vitamin B6 metabolism_Homo sapiens_hsa007501.15779383
32Epstein-Barr virus infection_Homo sapiens_hsa051691.13534473
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.12695240
34Systemic lupus erythematosus_Homo sapiens_hsa053221.08496230
35Folate biosynthesis_Homo sapiens_hsa007901.07868962
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.03432862
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.02619401
38Butanoate metabolism_Homo sapiens_hsa006501.02527531
39Oocyte meiosis_Homo sapiens_hsa041140.94209240
40Selenocompound metabolism_Homo sapiens_hsa004500.93990920
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92716644
42Biosynthesis of amino acids_Homo sapiens_hsa012300.90022693
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89353563
44Sulfur metabolism_Homo sapiens_hsa009200.88913724
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87246279
46Sulfur relay system_Homo sapiens_hsa041220.83534325
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83517527
48Fatty acid metabolism_Homo sapiens_hsa012120.83252599
49Pentose phosphate pathway_Homo sapiens_hsa000300.82919408
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81450915
51Glutathione metabolism_Homo sapiens_hsa004800.80569329
52Herpes simplex infection_Homo sapiens_hsa051680.80275518
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76983966
54Viral carcinogenesis_Homo sapiens_hsa052030.76176832
55N-Glycan biosynthesis_Homo sapiens_hsa005100.75709325
56Thyroid cancer_Homo sapiens_hsa052160.72863741
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68221756
58Adherens junction_Homo sapiens_hsa045200.67538921
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66721097
60Sphingolipid metabolism_Homo sapiens_hsa006000.61652299
61Legionellosis_Homo sapiens_hsa051340.59091000
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57354143
63Parkinsons disease_Homo sapiens_hsa050120.56414810
64Carbon metabolism_Homo sapiens_hsa012000.56152288
65Huntingtons disease_Homo sapiens_hsa050160.55944224
66Arginine biosynthesis_Homo sapiens_hsa002200.55211983
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.54073901
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51929763
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51836151
70HTLV-I infection_Homo sapiens_hsa051660.51083289
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49618120
72Shigellosis_Homo sapiens_hsa051310.49075465
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.46337272
74Antigen processing and presentation_Homo sapiens_hsa046120.45393451
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43550007
76Alcoholism_Homo sapiens_hsa050340.41379064
77Lysine degradation_Homo sapiens_hsa003100.40817886
78Metabolic pathways_Homo sapiens_hsa011000.39349290
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39338035
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37603629
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37056936
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32034421
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28634898
84Apoptosis_Homo sapiens_hsa042100.27332339
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27281740
86Regulation of autophagy_Homo sapiens_hsa041400.27046631
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27011342
88Measles_Homo sapiens_hsa051620.26635793
89Oxidative phosphorylation_Homo sapiens_hsa001900.26158738
90Retinol metabolism_Homo sapiens_hsa008300.24013822
91Chronic myeloid leukemia_Homo sapiens_hsa052200.22738805
92Galactose metabolism_Homo sapiens_hsa000520.22347314
93Fatty acid degradation_Homo sapiens_hsa000710.21677782
94MicroRNAs in cancer_Homo sapiens_hsa052060.21644363
95Pancreatic cancer_Homo sapiens_hsa052120.19215893
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19129368
97Proteoglycans in cancer_Homo sapiens_hsa052050.18523683
98Colorectal cancer_Homo sapiens_hsa052100.18480701
99Bladder cancer_Homo sapiens_hsa052190.18466533
100Hepatitis B_Homo sapiens_hsa051610.18277696
101Fructose and mannose metabolism_Homo sapiens_hsa000510.18057392
102Prostate cancer_Homo sapiens_hsa052150.17496903
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17433279
104Arginine and proline metabolism_Homo sapiens_hsa003300.17191994
105Small cell lung cancer_Homo sapiens_hsa052220.16751214
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.16373001
107Arachidonic acid metabolism_Homo sapiens_hsa005900.16106874
108Influenza A_Homo sapiens_hsa051640.15677067
109TGF-beta signaling pathway_Homo sapiens_hsa043500.15378470
110Tight junction_Homo sapiens_hsa045300.15284843
111Olfactory transduction_Homo sapiens_hsa047400.15138612
112Pyruvate metabolism_Homo sapiens_hsa006200.14501433
113Caffeine metabolism_Homo sapiens_hsa002320.11740067
114Renin-angiotensin system_Homo sapiens_hsa046140.10963053
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10231737
116Hematopoietic cell lineage_Homo sapiens_hsa046400.09615519
117Hippo signaling pathway_Homo sapiens_hsa043900.08993687
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.08766777
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08698814
120Peroxisome_Homo sapiens_hsa041460.08562727
121Primary immunodeficiency_Homo sapiens_hsa053400.07395070
122Other glycan degradation_Homo sapiens_hsa005110.05848086
123Melanoma_Homo sapiens_hsa052180.05555167
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0101606
125HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0038060
126NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0029180
127NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0013351

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