PSMD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of centriole replication (GO:0046599)5.90227616
2proteasome assembly (GO:0043248)5.20241976
3hepatocyte apoptotic process (GO:0097284)5.18705650
4* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.86896383
5cullin deneddylation (GO:0010388)4.83648508
6formation of translation preinitiation complex (GO:0001731)4.69556831
7* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.66188049
8protein deneddylation (GO:0000338)4.62163651
9purine nucleobase biosynthetic process (GO:0009113)4.61203791
10* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.55171772
11nucleobase biosynthetic process (GO:0046112)4.52428427
12* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.44886791
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.44296504
14regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.41279249
15positive regulation of keratinocyte differentiation (GO:0045618)4.40872529
16* negative regulation of ligase activity (GO:0051352)4.39924458
17* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.39924458
18* regulation of cellular amino acid metabolic process (GO:0006521)4.36817905
19maturation of SSU-rRNA (GO:0030490)4.32968194
20vagina development (GO:0060068)4.28131610
21* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.14590120
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.10616620
23ATP synthesis coupled proton transport (GO:0015986)4.10616620
24* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.06173405
25* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.06173405
26* positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.04414837
27* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.03639547
28* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.03639547
29* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.03639547
30ribosome assembly (GO:0042255)4.01339519
31peptidyl-arginine omega-N-methylation (GO:0035247)3.99002689
32termination of RNA polymerase III transcription (GO:0006386)3.96497944
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.96497944
34* signal transduction involved in DNA damage checkpoint (GO:0072422)3.95933405
35* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.95933405
36* signal transduction involved in cell cycle checkpoint (GO:0072395)3.91851191
37rRNA modification (GO:0000154)3.90874008
38* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.85551427
39* positive regulation of ligase activity (GO:0051351)3.85464117
40DNA strand elongation involved in DNA replication (GO:0006271)3.82540466
417-methylguanosine mRNA capping (GO:0006370)3.81827916
427-methylguanosine RNA capping (GO:0009452)3.74563471
43RNA capping (GO:0036260)3.74563471
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.74423489
45ribosomal large subunit biogenesis (GO:0042273)3.73649007
46ribosomal small subunit assembly (GO:0000028)3.70727276
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.68222850
48DNA strand elongation (GO:0022616)3.65456698
49intestinal epithelial cell development (GO:0060576)3.63568374
50telomere maintenance via semi-conservative replication (GO:0032201)3.62153168
51transcription elongation from RNA polymerase I promoter (GO:0006362)3.59848519
52spliceosomal snRNP assembly (GO:0000387)3.58706768
53* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.56923663
54DNA deamination (GO:0045006)3.56739089
55DNA replication checkpoint (GO:0000076)3.55352336
56ribosome biogenesis (GO:0042254)3.55338748
57* regulation of ubiquitin-protein transferase activity (GO:0051438)3.53725048
58ribonucleoprotein complex biogenesis (GO:0022613)3.49371334
59guanosine-containing compound biosynthetic process (GO:1901070)3.47094105
60termination of RNA polymerase I transcription (GO:0006363)3.45662665
61regulation of centrosome duplication (GO:0010824)3.45378889
62translation (GO:0006412)3.45326336
63* G1/S transition of mitotic cell cycle (GO:0000082)3.44194646
64* cell cycle G1/S phase transition (GO:0044843)3.44194646
65regulation of mitochondrial translation (GO:0070129)3.44166337
66DNA replication initiation (GO:0006270)3.43968895
67transcription-coupled nucleotide-excision repair (GO:0006283)3.43966218
68* regulation of ligase activity (GO:0051340)3.40075857
69peptidyl-arginine N-methylation (GO:0035246)3.40038385
70peptidyl-arginine methylation (GO:0018216)3.40038385
71positive regulation of translational initiation (GO:0045948)3.39361587
72rRNA processing (GO:0006364)3.37741931
73transcription from RNA polymerase I promoter (GO:0006360)3.37375171
74CENP-A containing nucleosome assembly (GO:0034080)3.36918374
75chaperone-mediated protein transport (GO:0072321)3.36903367
76establishment of integrated proviral latency (GO:0075713)3.35528294
77nucleobase-containing small molecule interconversion (GO:0015949)3.35367890
78regulation of centrosome cycle (GO:0046605)3.34202038
79IMP biosynthetic process (GO:0006188)3.31474769
80telomere maintenance via recombination (GO:0000722)3.28953906
81amino acid salvage (GO:0043102)3.28058147
82L-methionine salvage (GO:0071267)3.28058147
83L-methionine biosynthetic process (GO:0071265)3.28058147
84* positive regulation of cell cycle arrest (GO:0071158)3.27153593
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26597373
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26597373
87viral mRNA export from host cell nucleus (GO:0046784)3.26381974
88rRNA methylation (GO:0031167)3.26158563
89histone arginine methylation (GO:0034969)3.25795710
90chromatin remodeling at centromere (GO:0031055)3.25585070
91de novo protein folding (GO:0006458)3.25533227
92mitotic metaphase plate congression (GO:0007080)3.25486728
93ribosomal small subunit biogenesis (GO:0042274)3.24771860
94spliceosomal complex assembly (GO:0000245)3.23483741
95deoxyribonucleotide biosynthetic process (GO:0009263)3.22793920
96rRNA metabolic process (GO:0016072)3.22634477
97translational initiation (GO:0006413)3.21803492
98regulation of cell proliferation involved in kidney development (GO:1901722)3.21793019
99negative regulation of organelle assembly (GO:1902116)3.20589910
100female genitalia development (GO:0030540)3.20188797
101protein neddylation (GO:0045116)3.19445993
102cellular component biogenesis (GO:0044085)3.19307644
103SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18708058
104* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.17478399
105* regulation of cellular amine metabolic process (GO:0033238)3.16685603
106mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15440816
107mitochondrial respiratory chain complex I assembly (GO:0032981)3.15440816
108NADH dehydrogenase complex assembly (GO:0010257)3.15440816
109cotranslational protein targeting to membrane (GO:0006613)3.14615099
110pseudouridine synthesis (GO:0001522)3.14477570
111establishment of protein localization to mitochondrion (GO:0072655)3.13934290
112transcription initiation from RNA polymerase I promoter (GO:0006361)3.12827072
113translational termination (GO:0006415)3.12712310
114deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11923351
115peptidyl-histidine modification (GO:0018202)3.11483809
116regulation of establishment of cell polarity (GO:2000114)3.10205466
117protein targeting to mitochondrion (GO:0006626)3.10079249
118viral transcription (GO:0019083)3.09859410
119striated muscle atrophy (GO:0014891)3.09796415
120mitotic sister chromatid cohesion (GO:0007064)3.08535457
121muscle atrophy (GO:0014889)3.08158648
122positive regulation of epidermal cell differentiation (GO:0045606)3.05561282
123DNA topological change (GO:0006265)2.93318983
124DNA replication-independent nucleosome assembly (GO:0006336)2.82822540
125DNA replication-independent nucleosome organization (GO:0034724)2.82822540
126regulation of establishment or maintenance of cell polarity (GO:0032878)2.82089109
127folic acid-containing compound biosynthetic process (GO:0009396)2.79050166
128skeletal muscle adaptation (GO:0043501)2.76632481
129DNA replication-dependent nucleosome assembly (GO:0006335)2.73735264
130DNA replication-dependent nucleosome organization (GO:0034723)2.73735264
131TOR signaling (GO:0031929)2.72253541
132ear development (GO:0043583)2.71747891
133termination of RNA polymerase II transcription (GO:0006369)2.71486690
134histone exchange (GO:0043486)2.69844920
135double-strand break repair via nonhomologous end joining (GO:0006303)2.69399533
136non-recombinational repair (GO:0000726)2.69399533
137DNA ligation (GO:0006266)2.66915619
138DNA unwinding involved in DNA replication (GO:0006268)2.66175825
139ER overload response (GO:0006983)2.65111576
140regulation of helicase activity (GO:0051095)2.62316080
141metaphase plate congression (GO:0051310)2.62070085
142pteridine-containing compound biosynthetic process (GO:0042559)2.60615109
143regulation of translational initiation (GO:0006446)2.60101583
144uterus development (GO:0060065)2.55278952
145* negative regulation of protein ubiquitination (GO:0031397)2.54267541
146positive regulation of Cdc42 GTPase activity (GO:0043089)2.53612690
147mitotic recombination (GO:0006312)2.52269707
148Golgi transport vesicle coating (GO:0048200)2.51960754
149COPI coating of Golgi vesicle (GO:0048205)2.51960754
150* signal transduction in response to DNA damage (GO:0042770)2.51820977

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.28156361
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.79733012
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.54030294
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.23504548
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.98553045
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.98130743
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.94515234
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.72247182
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.61740084
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.18825336
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12706456
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09387706
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.03560379
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.01460183
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93382577
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88212530
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.87119474
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73558555
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73278542
20* VDR_23849224_ChIP-Seq_CD4+_Human2.65563971
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.60509316
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56991639
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.51466036
24XRN2_22483619_ChIP-Seq_HELA_Human2.50797288
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.49821114
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.45541974
27DCP1A_22483619_ChIP-Seq_HELA_Human2.45476972
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42098957
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40893145
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30977417
31* GABP_19822575_ChIP-Seq_HepG2_Human2.24817399
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.23429502
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21498218
34FOXP3_21729870_ChIP-Seq_TREG_Human2.18749312
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16438488
36* ELK1_19687146_ChIP-ChIP_HELA_Human2.15270864
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12984072
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11453285
39FOXM1_23109430_ChIP-Seq_U2OS_Human2.04047652
40TTF2_22483619_ChIP-Seq_HELA_Human2.03522836
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98474454
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.92978303
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89060857
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88812213
45AR_21909140_ChIP-Seq_LNCAP_Human1.87776122
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85545595
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79417310
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79247779
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77229660
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77196905
51* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76842435
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75142651
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69145256
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64168728
55* ER_23166858_ChIP-Seq_MCF-7_Human1.61298621
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55323496
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49745777
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46914008
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.44913962
60ZNF263_19887448_ChIP-Seq_K562_Human1.43639176
61PKCTHETA_26484144_Chip-Seq_BREAST_Human1.42632139
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.42026312
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.40168628
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37252158
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34794365
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32828152
67GATA3_24758297_ChIP-Seq_MCF-7_Human1.32732723
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32259644
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.31574846
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31337030
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29074211
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25489195
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.24746793
74KDM5A_27292631_Chip-Seq_BREAST_Human1.23900383
75ELF5_23300383_ChIP-Seq_T47D_Human1.22790949
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20642042
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18731413
78CIITA_25753668_ChIP-Seq_RAJI_Human1.17591758
79* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14146057
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12852804
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12631777
82* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11476509
83SOX17_20123909_ChIP-Seq_XEN_Mouse1.09728151
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08915294
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08803568
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07618204
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07206814
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06735266
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06218864
90TFEB_21752829_ChIP-Seq_HELA_Human1.05714468
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04499777
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02960005
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01543271
94MYC_18940864_ChIP-ChIP_HL60_Human1.01508771
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.00690406
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98474175
97CHD1_26751641_Chip-Seq_LNCaP_Human0.98189231
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96531759
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95575126
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.90686701
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87929094
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86731035
103FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86319674
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86001788
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85548884
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85420225
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83608963
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83246965
109GATA1_22025678_ChIP-Seq_K562_Human0.81997949
110IRF1_19129219_ChIP-ChIP_H3396_Human0.81953359
111* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81618131
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80735335
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78904274
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78691488
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78596283
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77750213
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74654872
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.74508278
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74346205
120* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73704315
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.73438245
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73254539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.03532182
2MP0004957_abnormal_blastocyst_morpholog4.69716462
3MP0003806_abnormal_nucleotide_metabolis4.02484550
4MP0010094_abnormal_chromosome_stability3.85695263
5MP0003077_abnormal_cell_cycle3.54459833
6MP0008058_abnormal_DNA_repair3.43080145
7MP0003111_abnormal_nucleus_morphology3.43039734
8MP0008932_abnormal_embryonic_tissue3.21413950
9MP0003123_paternal_imprinting3.02667268
10MP0005075_abnormal_melanosome_morpholog2.69658191
11MP0003186_abnormal_redox_activity2.57255780
12MP0004264_abnormal_extraembryonic_tissu2.55068124
13MP0008007_abnormal_cellular_replicative2.52423299
14MP0002796_impaired_skin_barrier2.50767302
15MP0003718_maternal_effect2.28939375
16MP0001730_embryonic_growth_arrest2.28643030
17MP0008057_abnormal_DNA_replication2.25384895
18MP0008995_early_reproductive_senescence2.19024883
19MP0004381_abnormal_hair_follicle2.17735327
20MP0010030_abnormal_orbit_morphology2.17029292
21MP0009379_abnormal_foot_pigmentation2.13449801
22MP0004233_abnormal_muscle_weight2.08587443
23MP0005076_abnormal_cell_differentiation2.06241937
24MP0006036_abnormal_mitochondrial_physio1.98405875
25MP0006054_spinal_hemorrhage1.98138024
26MP0009697_abnormal_copulation1.95811120
27MP0000383_abnormal_hair_follicle1.94004909
28MP0003786_premature_aging1.93568914
29MP0009780_abnormal_chondrocyte_physiolo1.90311796
30MP0005501_abnormal_skin_physiology1.87452488
31MP0006035_abnormal_mitochondrial_morpho1.80976805
32MP0001542_abnormal_bone_strength1.79887500
33MP0000427_abnormal_hair_cycle1.76181593
34MP0001529_abnormal_vocalization1.75365093
35MP0003941_abnormal_skin_development1.70956406
36MP0000350_abnormal_cell_proliferation1.70558694
37MP0001873_stomach_inflammation1.70382893
38MP0002098_abnormal_vibrissa_morphology1.63136682
39MP0010678_abnormal_skin_adnexa1.62306101
40MP0008260_abnormal_autophagy1.62095000
41MP0003221_abnormal_cardiomyocyte_apopto1.61768162
42MP0002877_abnormal_melanocyte_morpholog1.57685369
43MP0000627_abnormal_mammary_gland1.55941504
44MP0002938_white_spotting1.48184046
45MP0000358_abnormal_cell_content/1.45060077
46MP0002638_abnormal_pupillary_reflex1.43935253
47MP0001697_abnormal_embryo_size1.42941282
48MP0000462_abnormal_digestive_system1.41310356
49MP0008877_abnormal_DNA_methylation1.38822437
50MP0010234_abnormal_vibrissa_follicle1.37662387
51MP0001764_abnormal_homeostasis1.36680720
52MP0002080_prenatal_lethality1.33568870
53MP0001986_abnormal_taste_sensitivity1.30466670
54MP0003121_genomic_imprinting1.28409665
55MP0003315_abnormal_perineum_morphology1.27791809
56MP0004782_abnormal_surfactant_physiolog1.27251902
57MP0005408_hypopigmentation1.26290113
58MP0003567_abnormal_fetal_cardiomyocyte1.25708544
59MP0005380_embryogenesis_phenotype1.24597845
60MP0001672_abnormal_embryogenesis/_devel1.24597845
61MP0003936_abnormal_reproductive_system1.19417793
62MP0004147_increased_porphyrin_level1.18931242
63MP0006292_abnormal_olfactory_placode1.17751077
64MP0009703_decreased_birth_body1.17466682
65MP0001881_abnormal_mammary_gland1.17086730
66MP0000313_abnormal_cell_death1.16997758
67MP0000377_abnormal_hair_follicle1.16838054
68MP0002396_abnormal_hematopoietic_system1.15177723
69MP0002751_abnormal_autonomic_nervous1.14283520
70MP0002160_abnormal_reproductive_system1.13986636
71MP0001919_abnormal_reproductive_system1.13958483
72MP0000537_abnormal_urethra_morphology1.13746310
73MP0003984_embryonic_growth_retardation1.09129303
74MP0004133_heterotaxia1.06417327
75MP0002088_abnormal_embryonic_growth/wei1.05209380
76MP0008789_abnormal_olfactory_epithelium1.04824297
77MP0009333_abnormal_splenocyte_physiolog1.04778640
78MP0002085_abnormal_embryonic_tissue1.04083085
79MP0003787_abnormal_imprinting1.03050658
80MP0005646_abnormal_pituitary_gland1.02663642
81MP0005503_abnormal_tendon_morphology1.02371840
82MP0003122_maternal_imprinting1.00612832
83MP0001727_abnormal_embryo_implantation0.97953795
84MP0002736_abnormal_nociception_after0.97389535
85MP0000371_diluted_coat_color0.96388190
86MP0005220_abnormal_exocrine_pancreas0.96240001
87MP0008872_abnormal_physiological_respon0.95057566
88MP0000579_abnormal_nail_morphology0.94698785
89MP0005083_abnormal_biliary_tract0.94675982
90MP0003890_abnormal_embryonic-extraembry0.94429959
91MP0001186_pigmentation_phenotype0.92769395
92MP0000647_abnormal_sebaceous_gland0.91499450
93MP0001293_anophthalmia0.90059968
94MP0002132_abnormal_respiratory_system0.89373422
95MP0003656_abnormal_erythrocyte_physiolo0.89286419
96MP0005389_reproductive_system_phenotype0.88891433
97MP0005266_abnormal_metabolism0.88475920
98MP0000538_abnormal_urinary_bladder0.86601027
99MP0000749_muscle_degeneration0.85932700
100MP0002009_preneoplasia0.83956482
101MP0005084_abnormal_gallbladder_morpholo0.83374094
102MP0005332_abnormal_amino_acid0.83036829
103MP0002075_abnormal_coat/hair_pigmentati0.82295380
104MP0000490_abnormal_crypts_of0.81340842
105MP0001145_abnormal_male_reproductive0.81198884
106MP0000750_abnormal_muscle_regeneration0.80950022
107MP0002210_abnormal_sex_determination0.80660183
108MP0002084_abnormal_developmental_patter0.80361729
109MP0003119_abnormal_digestive_system0.80032570
110MP0001905_abnormal_dopamine_level0.79446445
111MP0001216_abnormal_epidermal_layer0.77208381
112MP0010307_abnormal_tumor_latency0.76223720
113MP0004197_abnormal_fetal_growth/weight/0.75611917
114MP0000049_abnormal_middle_ear0.75423642
115MP0002019_abnormal_tumor_incidence0.75048042
116MP0005248_abnormal_Harderian_gland0.74397288
117MP0010771_integument_phenotype0.73700693
118MP0001119_abnormal_female_reproductive0.73624223
119MP0002269_muscular_atrophy0.73431829
120MP0004084_abnormal_cardiac_muscle0.71125996
121MP0002086_abnormal_extraembryonic_tissu0.71079453
122MP0002163_abnormal_gland_morphology0.70709628
123MP0002111_abnormal_tail_morphology0.69939894
124MP0005384_cellular_phenotype0.68735223
125MP0002102_abnormal_ear_morphology0.68699022
126MP0005376_homeostasis/metabolism_phenot0.68687183
127MP0002970_abnormal_white_adipose0.67222150
128MP0000372_irregular_coat_pigmentation0.66895346
129MP0000703_abnormal_thymus_morphology0.66858752
130MP0000653_abnormal_sex_gland0.66665591
131MP0000470_abnormal_stomach_morphology0.65800935
132MP0005451_abnormal_body_composition0.65473484
133MP0006276_abnormal_autonomic_nervous0.65039543
134MP0003705_abnormal_hypodermis_morpholog0.64770183
135MP0009672_abnormal_birth_weight0.63307153
136MP0000747_muscle_weakness0.61916876
137MP0001929_abnormal_gametogenesis0.61085856
138MP0002127_abnormal_cardiovascular_syste0.60679934
139MP0008438_abnormal_cutaneous_collagen0.58928955
140MP0005636_abnormal_mineral_homeostasis0.56426803
141MP0001666_abnormal_nutrient_absorption0.55211833
142MP0001243_abnormal_dermal_layer0.53704832
143MP0003942_abnormal_urinary_system0.53487022
144MP0004145_abnormal_muscle_electrophysio0.52605172
145MP0001853_heart_inflammation0.51787307

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.64828922
2J-shaped sella turcica (HP:0002680)5.37456999
3Chromsome breakage (HP:0040012)5.23792052
4Acute necrotizing encephalopathy (HP:0006965)4.79711794
5Microglossia (HP:0000171)4.67216726
6Asymmetry of the thorax (HP:0001555)4.64205006
7Birth length less than 3rd percentile (HP:0003561)4.58218756
8Septate vagina (HP:0001153)4.39727508
9Absent frontal sinuses (HP:0002688)4.35941850
10Abnormal mitochondria in muscle tissue (HP:0008316)4.35523445
11Mitochondrial inheritance (HP:0001427)4.19461626
12Breast carcinoma (HP:0003002)4.18843438
13Increased CSF lactate (HP:0002490)4.15137555
14Abnormality of glycolysis (HP:0004366)4.11062021
15Increased serum pyruvate (HP:0003542)4.11062021
16Cerebral hypomyelination (HP:0006808)4.08129363
17Acute encephalopathy (HP:0006846)4.06638645
18Micronodular cirrhosis (HP:0001413)3.86001624
19Increased hepatocellular lipid droplets (HP:0006565)3.82331493
20Progressive macrocephaly (HP:0004481)3.79808888
21Cutaneous melanoma (HP:0012056)3.71411979
22Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.64424621
23Lipid accumulation in hepatocytes (HP:0006561)3.60419723
24Hepatocellular necrosis (HP:0001404)3.54775497
25Abnormality of the preputium (HP:0100587)3.44434986
26Hepatic necrosis (HP:0002605)3.40627308
27Degeneration of anterior horn cells (HP:0002398)3.39701461
28Abnormality of the anterior horn cell (HP:0006802)3.39701461
29Meckel diverticulum (HP:0002245)3.38700972
30Breast hypoplasia (HP:0003187)3.38566884
31Abnormality of chromosome stability (HP:0003220)3.32106065
32Increased serum lactate (HP:0002151)3.31355078
33Aplasia/Hypoplasia of the uvula (HP:0010293)3.31049217
34Nephroblastoma (Wilms tumor) (HP:0002667)3.27665080
35Abnormality of the ileum (HP:0001549)3.22872102
36Decreased activity of mitochondrial respiratory chain (HP:0008972)3.20169041
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.20169041
38Oral leukoplakia (HP:0002745)3.19340135
39Abnormality of the frontal sinuses (HP:0002687)3.15647650
40Rough bone trabeculation (HP:0100670)3.13219440
41Embryonal renal neoplasm (HP:0011794)3.09048452
42Abnormality of cells of the erythroid lineage (HP:0012130)3.03746140
433-Methylglutaconic aciduria (HP:0003535)3.02075636
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.99105693
45Cerebral edema (HP:0002181)2.98395912
46Carpal bone hypoplasia (HP:0001498)2.97635006
47Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.95590726
48Thyroid carcinoma (HP:0002890)2.88152673
49Exercise intolerance (HP:0003546)2.88101247
50Deformed sella turcica (HP:0002681)2.84783334
51Concave nail (HP:0001598)2.83842867
52Reticulocytopenia (HP:0001896)2.80438064
53Lactic acidosis (HP:0003128)2.79786643
54Abnormality of alanine metabolism (HP:0010916)2.77398921
55Hyperalaninemia (HP:0003348)2.77398921
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77398921
57Abnormal number of erythroid precursors (HP:0012131)2.75638430
58Aplastic anemia (HP:0001915)2.74412165
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71472750
60Type I transferrin isoform profile (HP:0003642)2.67385063
61Renal Fanconi syndrome (HP:0001994)2.65731573
62Increased intramyocellular lipid droplets (HP:0012240)2.64004604
63Testicular atrophy (HP:0000029)2.61204527
64Trismus (HP:0000211)2.59209709
65Multiple enchondromatosis (HP:0005701)2.56452169
66Secondary amenorrhea (HP:0000869)2.56363034
67Respiratory failure (HP:0002878)2.54308905
68Irregular epiphyses (HP:0010582)2.52492684
69Macrocytic anemia (HP:0001972)2.51096518
70CNS demyelination (HP:0007305)2.47361162
71Curly hair (HP:0002212)2.46258997
72Abnormal trabecular bone morphology (HP:0100671)2.45573642
73Papillary thyroid carcinoma (HP:0002895)2.41294574
74Exertional dyspnea (HP:0002875)2.40719507
75Abnormality of the carotid arteries (HP:0005344)2.40417874
76Abnormality of the fetal cardiovascular system (HP:0010948)2.39531825
77Abnormal umbilical cord blood vessels (HP:0011403)2.39531825
78Single umbilical artery (HP:0001195)2.39531825
79Postnatal microcephaly (HP:0005484)2.38044090
80Microretrognathia (HP:0000308)2.34138726
81Leukodystrophy (HP:0002415)2.33817130
82Duodenal stenosis (HP:0100867)2.32640462
83Small intestinal stenosis (HP:0012848)2.32640462
84Myelodysplasia (HP:0002863)2.31919653
85Glossoptosis (HP:0000162)2.30298198
86Colon cancer (HP:0003003)2.30106557
87Respiratory difficulties (HP:0002880)2.29323352
88Microvesicular hepatic steatosis (HP:0001414)2.29141858
89Megaloblastic anemia (HP:0001889)2.27881798
90Increased muscle lipid content (HP:0009058)2.27174374
91CNS hypomyelination (HP:0003429)2.25987623
92Triphalangeal thumb (HP:0001199)2.16377686
93Patellar aplasia (HP:0006443)2.15742986
94Neoplasm of the thyroid gland (HP:0100031)2.14527959
95Premature graying of hair (HP:0002216)2.12820674
96Poor head control (HP:0002421)2.12425928
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11850719
98Abnormal protein N-linked glycosylation (HP:0012347)2.11850719
99Abnormal protein glycosylation (HP:0012346)2.11850719
100Abnormal glycosylation (HP:0012345)2.11850719
101Progressive muscle weakness (HP:0003323)2.10266116
102Lethargy (HP:0001254)2.06270999
103Clubbing of toes (HP:0100760)2.05856706
104Short thumb (HP:0009778)2.04035299
105Emotional lability (HP:0000712)2.03744730
106Unsteady gait (HP:0002317)2.03402884
107Medulloblastoma (HP:0002885)2.03147479
108Meningioma (HP:0002858)2.02345302
109Neoplasm of the adrenal gland (HP:0100631)2.02031280
110Aplasia/Hypoplasia of the patella (HP:0006498)1.99923077
111Abnormalities of placenta or umbilical cord (HP:0001194)1.99695217
112Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99074444
113High pitched voice (HP:0001620)1.96743145
114Pallor (HP:0000980)1.96667632
115Deep philtrum (HP:0002002)1.96607789
116Calcaneovalgus deformity (HP:0001848)1.96162740
117Melanoma (HP:0002861)1.95221670
118Hypopigmentation of the fundus (HP:0007894)1.95108274
119Spinal cord lesions (HP:0100561)1.95070094
120Syringomyelia (HP:0003396)1.95070094
121Aplasia/Hypoplasia involving the musculature (HP:0001460)1.94096668
122Nemaline bodies (HP:0003798)1.94061878
12311 pairs of ribs (HP:0000878)1.93981514
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93887797
125Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91923556
126Arteriovenous malformation (HP:0100026)1.91813451
127Atrophy/Degeneration involving motor neurons (HP:0007373)1.91556185
128Reduced antithrombin III activity (HP:0001976)1.89314494
129Redundant skin (HP:0001582)1.89239786
130Bone marrow hypocellularity (HP:0005528)1.88960513
131Delusions (HP:0000746)1.87912556
132Enlarged penis (HP:0000040)1.87733889
133Rimmed vacuoles (HP:0003805)1.87626425
134Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86504927
135Optic disc pallor (HP:0000543)1.85562142
136Spastic paraparesis (HP:0002313)1.83907400
137Abnormality of the duodenum (HP:0002246)1.83899959
138Abnormality of the umbilical cord (HP:0010881)1.83565998
139Abnormality of urine glucose concentration (HP:0011016)1.83241852
140Glycosuria (HP:0003076)1.83241852
141Absent radius (HP:0003974)1.82941825
142Abnormality of the pons (HP:0007361)1.82450056
143Stenosis of the external auditory canal (HP:0000402)1.81823883
144Abnormality of the sella turcica (HP:0002679)1.81524144
145Abnormal lung lobation (HP:0002101)1.81378365
146Cellular immunodeficiency (HP:0005374)1.79973350
147Patent foramen ovale (HP:0001655)1.79885377
148Abnormality of serum amino acid levels (HP:0003112)1.79798873
149Neoplasm of the pancreas (HP:0002894)1.79286298
150Absent thumb (HP:0009777)1.79179306
151Slender long bone (HP:0003100)1.78680440
152Impulsivity (HP:0100710)1.77760847
153Shoulder girdle muscle weakness (HP:0003547)1.77306633
154Selective tooth agenesis (HP:0001592)1.76931394
155Facial cleft (HP:0002006)1.76755083
156Adrenal hypoplasia (HP:0000835)1.76441247
157Uterine neoplasm (HP:0010784)1.75281500
158Deformed tarsal bones (HP:0008119)1.74909505
159Embryonal neoplasm (HP:0002898)1.74866963
160Progressive external ophthalmoplegia (HP:0000590)1.73662998
161Conjunctival hamartoma (HP:0100780)1.73573902
162Pancytopenia (HP:0001876)1.73019145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.96754735
2EIF2AK14.47825273
3STK163.70707213
4WEE13.66216783
5PIK3CA3.41898788
6EIF2AK32.97592137
7NME22.92410922
8VRK22.90160392
9PKN22.85895272
10TSSK62.76731941
11TRIM282.68834455
12PBK2.68500497
13NME12.45559891
14MUSK2.43019076
15TRIB32.36545402
16SRPK12.34479076
17PLK42.33057125
18NEK62.30107774
19BRSK22.21701985
20ACVR1B2.21487912
21VRK12.18396237
22CDC71.98893899
23NEK11.95856107
24PLK31.95089640
25LIMK11.89597202
26SIK11.82445711
27ZAK1.75535679
28MKNK11.60961947
29PLK11.55396209
30MST41.52950629
31TESK21.52044111
32TAF11.49486305
33BCKDK1.49342370
34NUAK11.47056208
35BRSK11.45287023
36TESK11.43513877
37PASK1.39199662
38PIM21.38625886
39BCR1.38510987
40SMG11.35676060
41AURKA1.31626417
42DYRK31.23242718
43CHUK1.22665654
44BRAF1.17771969
45TTK1.16396168
46AURKB1.13555277
47ERBB31.11460679
48DYRK21.07928297
49ARAF1.04306124
50NEK21.01531750
51PDK30.99242363
52PDK40.99242363
53EIF2AK20.98777902
54ATR0.97473733
55SIK30.95337400
56TGFBR10.94704971
57TLK10.94508367
58EPHA20.94417334
59SCYL20.94171237
60PNCK0.93203617
61RPS6KB20.93149891
62IRAK30.91502545
63KDR0.88893887
64RPS6KB10.87256073
65CCNB10.87196811
66CDK70.85671883
67OBSCN0.85205764
68CHEK20.82173069
69MKNK20.80002756
70CSNK1G30.77983807
71CSNK2A10.75911814
72PLK20.73085522
73CDK80.73022250
74CSNK2A20.70809169
75PAK10.69312085
76DAPK10.69022507
77PRKCI0.66562198
78RPS6KA40.65727544
79CHEK10.64115952
80WNK30.63012344
81IKBKE0.62473307
82CDK60.61235137
83IKBKB0.59067089
84STK38L0.58355746
85ILK0.56934995
86GRK60.56573532
87STK40.55211917
88PAK40.53885191
89MAP3K80.53540985
90PIK3CG0.50432088
91CLK10.49616170
92PDK20.49215898
93MAP2K10.49214660
94MAP3K120.49171254
95CAMK2G0.47735213
96CSF1R0.46831827
97AKT20.45636097
98RPS6KA50.45483565
99AKT30.44873892
100BMPR1B0.44219206
101CSNK1G10.43884913
102CAMK2D0.43881743
103MAPKAPK20.43706431
104ABL20.42288212
105MAP4K20.41997630
106FGFR20.41741343
107MAP3K110.41039587
108ATM0.39774347
109MYLK0.39561971
110NEK90.38799502
111STK240.38536650
112MARK30.38326288
113CDK140.37851822
114ALK0.37123798
115CAMK2B0.36610324
116CDK20.35497713
117GRK70.35473587
118YES10.34974074
119CDK10.34650836
120PTK60.33129944
121FGFR10.32466393
122BMPR20.30767614
123CSNK1G20.29294953
124CSNK1D0.28815793
125CDK180.28427000
126MELK0.28206189
127MAP2K20.26153625
128CSNK1E0.24363696
129LRRK20.24317797
130PRKCG0.23549932
131CSNK1A1L0.23545212
132ADRBK20.22893726
133CDK11A0.21841336
134MAPKAPK30.21605926
135CDK150.21413196

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.32353502
2RNA polymerase_Homo sapiens_hsa030203.76729044
3DNA replication_Homo sapiens_hsa030303.54617220
4Ribosome_Homo sapiens_hsa030103.52949197
5Mismatch repair_Homo sapiens_hsa034303.26554044
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21844820
7Protein export_Homo sapiens_hsa030602.68308922
8Spliceosome_Homo sapiens_hsa030402.67795297
9Oxidative phosphorylation_Homo sapiens_hsa001902.61321180
10Pyrimidine metabolism_Homo sapiens_hsa002402.60862008
11RNA transport_Homo sapiens_hsa030132.55994062
12Nucleotide excision repair_Homo sapiens_hsa034202.50569107
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48205775
14Parkinsons disease_Homo sapiens_hsa050122.44828923
15Homologous recombination_Homo sapiens_hsa034402.08066051
16Base excision repair_Homo sapiens_hsa034102.06002796
17Huntingtons disease_Homo sapiens_hsa050161.90003412
18Cell cycle_Homo sapiens_hsa041101.82327631
19One carbon pool by folate_Homo sapiens_hsa006701.78282125
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68522242
21Basal transcription factors_Homo sapiens_hsa030221.66539288
22RNA degradation_Homo sapiens_hsa030181.57390995
23Non-homologous end-joining_Homo sapiens_hsa034501.50882886
24Purine metabolism_Homo sapiens_hsa002301.50041793
25Alzheimers disease_Homo sapiens_hsa050101.47612151
26Folate biosynthesis_Homo sapiens_hsa007901.44008770
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30165964
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29800164
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29506459
30Fanconi anemia pathway_Homo sapiens_hsa034601.20941817
31Vitamin B6 metabolism_Homo sapiens_hsa007501.20803147
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.17300134
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16244552
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15042959
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14096097
36Biosynthesis of amino acids_Homo sapiens_hsa012301.12296404
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.07080885
38Glutathione metabolism_Homo sapiens_hsa004801.06181263
39Selenocompound metabolism_Homo sapiens_hsa004501.02657906
40Carbon metabolism_Homo sapiens_hsa012001.02473813
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00693759
42Pentose phosphate pathway_Homo sapiens_hsa000300.99732377
43* Epstein-Barr virus infection_Homo sapiens_hsa051690.96472294
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94998167
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91944918
46Regulation of autophagy_Homo sapiens_hsa041400.89044090
47Endometrial cancer_Homo sapiens_hsa052130.88606161
48p53 signaling pathway_Homo sapiens_hsa041150.87633938
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85201365
50Pyruvate metabolism_Homo sapiens_hsa006200.83539623
51mRNA surveillance pathway_Homo sapiens_hsa030150.79578766
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.77806546
53Sulfur relay system_Homo sapiens_hsa041220.76863893
54Systemic lupus erythematosus_Homo sapiens_hsa053220.75700035
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74270768
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73588648
57Metabolic pathways_Homo sapiens_hsa011000.72070361
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67560140
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65629902
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63913854
61Acute myeloid leukemia_Homo sapiens_hsa052210.63570099
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62750801
63Fructose and mannose metabolism_Homo sapiens_hsa000510.62565988
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61622665
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61002004
66Legionellosis_Homo sapiens_hsa051340.58624525
67N-Glycan biosynthesis_Homo sapiens_hsa005100.55864946
68Non-small cell lung cancer_Homo sapiens_hsa052230.55539253
69Cardiac muscle contraction_Homo sapiens_hsa042600.54063669
70Arginine and proline metabolism_Homo sapiens_hsa003300.52514136
71Oocyte meiosis_Homo sapiens_hsa041140.52207928
72Bladder cancer_Homo sapiens_hsa052190.51240340
73mTOR signaling pathway_Homo sapiens_hsa041500.50020220
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.49762471
75Steroid biosynthesis_Homo sapiens_hsa001000.49583785
76Vibrio cholerae infection_Homo sapiens_hsa051100.47629608
77Propanoate metabolism_Homo sapiens_hsa006400.45985390
78AMPK signaling pathway_Homo sapiens_hsa041520.45808054
79Prostate cancer_Homo sapiens_hsa052150.45740156
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.45264952
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42843611
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41775181
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40743368
84Melanoma_Homo sapiens_hsa052180.39644275
85Fatty acid elongation_Homo sapiens_hsa000620.37383475
86Antigen processing and presentation_Homo sapiens_hsa046120.37104159
87Arachidonic acid metabolism_Homo sapiens_hsa005900.36676088
88Galactose metabolism_Homo sapiens_hsa000520.33887699
89Peroxisome_Homo sapiens_hsa041460.33080807
90Viral carcinogenesis_Homo sapiens_hsa052030.32112512
91Tight junction_Homo sapiens_hsa045300.31378544
92Tyrosine metabolism_Homo sapiens_hsa003500.29080030
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26748340
94Phenylalanine metabolism_Homo sapiens_hsa003600.26716510
95Hepatitis C_Homo sapiens_hsa051600.26333861
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26208162
97Colorectal cancer_Homo sapiens_hsa052100.26182630
98Sulfur metabolism_Homo sapiens_hsa009200.25950263
99Phagosome_Homo sapiens_hsa041450.23671759
100Hepatitis B_Homo sapiens_hsa051610.23429201
101HIF-1 signaling pathway_Homo sapiens_hsa040660.22780180
102Chemical carcinogenesis_Homo sapiens_hsa052040.22392308
103Alcoholism_Homo sapiens_hsa050340.22188669
104Butanoate metabolism_Homo sapiens_hsa006500.21528125
105Inositol phosphate metabolism_Homo sapiens_hsa005620.20957740
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19646183
107Collecting duct acid secretion_Homo sapiens_hsa049660.19105823
108Chronic myeloid leukemia_Homo sapiens_hsa052200.18906338
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18804963
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18153418
111Renal cell carcinoma_Homo sapiens_hsa052110.18025866
112Fatty acid metabolism_Homo sapiens_hsa012120.17412745
113Hippo signaling pathway_Homo sapiens_hsa043900.15959999
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15570556
115Insulin signaling pathway_Homo sapiens_hsa049100.14250627
116Renin-angiotensin system_Homo sapiens_hsa046140.12701511
117Thyroid cancer_Homo sapiens_hsa052160.09903773
118Fat digestion and absorption_Homo sapiens_hsa049750.07583792
119Linoleic acid metabolism_Homo sapiens_hsa005910.06699713
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05793637
121HTLV-I infection_Homo sapiens_hsa051660.05103537
122TGF-beta signaling pathway_Homo sapiens_hsa043500.04820204
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.01303953
124Vitamin digestion and absorption_Homo sapiens_hsa049770.01230909
125Herpes simplex infection_Homo sapiens_hsa051680.00846326

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