PSMD7P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein complex biogenesis (GO:0070271)5.66146063
2mitochondrial respiratory chain complex I assembly (GO:0032981)5.53730033
3NADH dehydrogenase complex assembly (GO:0010257)5.53730033
4mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.53730033
5GMP metabolic process (GO:0046037)5.38707855
6mitochondrial respiratory chain complex assembly (GO:0033108)5.27311842
7behavioral response to nicotine (GO:0035095)5.23617498
8cullin deneddylation (GO:0010388)4.99370560
9respiratory chain complex IV assembly (GO:0008535)4.78624102
10cytochrome complex assembly (GO:0017004)4.59224265
11protein neddylation (GO:0045116)4.48703121
12activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.39900531
13interferon-gamma production (GO:0032609)4.37361959
14positive regulation of T cell cytokine production (GO:0002726)4.19313904
15protein deneddylation (GO:0000338)4.18003270
16positive regulation of T cell chemotaxis (GO:0010820)4.12061033
17regulation of T cell chemotaxis (GO:0010819)4.12061033
18energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90906061
19ATP synthesis coupled proton transport (GO:0015986)3.90906061
20purine nucleobase biosynthetic process (GO:0009113)3.86460855
21regulation of gamma-delta T cell differentiation (GO:0045586)3.81838822
22negative regulation of thymocyte apoptotic process (GO:0070244)3.80964086
23negative regulation of T cell mediated immunity (GO:0002710)3.77462713
24positive regulation of T-helper 1 type immune response (GO:0002827)3.76334975
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.75412141
26IMP biosynthetic process (GO:0006188)3.66103035
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.65523364
28monoubiquitinated protein deubiquitination (GO:0035520)3.63562673
29purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.63481510
30adenosine metabolic process (GO:0046085)3.60873171
31DNA deamination (GO:0045006)3.60844771
32positive regulation of gamma-delta T cell activation (GO:0046645)3.57174893
33mucosal-associated lymphoid tissue development (GO:0048537)3.54722121
34Peyers patch development (GO:0048541)3.54722121
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48501408
36water-soluble vitamin biosynthetic process (GO:0042364)3.41447636
37deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.41253186
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38850618
39lymphocyte chemotaxis (GO:0048247)3.22586403
40proteasome assembly (GO:0043248)3.17650467
41positive regulation of protein homodimerization activity (GO:0090073)3.16432976
42nucleobase biosynthetic process (GO:0046112)3.09283438
43sequestering of actin monomers (GO:0042989)3.05449270
44vitamin biosynthetic process (GO:0009110)3.04156641
45RNA destabilization (GO:0050779)3.03177836
46axonemal dynein complex assembly (GO:0070286)3.03128793
47protein K6-linked ubiquitination (GO:0085020)3.01825610
48regulation of gamma-delta T cell activation (GO:0046643)3.01335915
49positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.98086810
50positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97091169
51folic acid-containing compound biosynthetic process (GO:0009396)2.96256498
52positive regulation of uterine smooth muscle contraction (GO:0070474)2.95986606
53DNA damage response, detection of DNA damage (GO:0042769)2.95565417
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94581661
55intra-S DNA damage checkpoint (GO:0031573)2.92086167
56viral mRNA export from host cell nucleus (GO:0046784)2.91055402
57negative regulation of telomere maintenance (GO:0032205)2.90461473
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89757752
59aspartate family amino acid catabolic process (GO:0009068)2.89298238
60regulation of rhodopsin mediated signaling pathway (GO:0022400)2.84433014
61purine nucleotide salvage (GO:0032261)2.84005848
62positive regulation of T cell differentiation in thymus (GO:0033089)2.82299735
63IMP metabolic process (GO:0046040)2.80494552
64regulation of cellular amino acid metabolic process (GO:0006521)2.78921328
65regulation of mitotic spindle checkpoint (GO:1903504)2.78215475
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78215475
67axoneme assembly (GO:0035082)2.77309670
68regulation of T cell cytokine production (GO:0002724)2.75749161
69positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75448896
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.72460921
71fat-soluble vitamin biosynthetic process (GO:0042362)2.66865646
72negative regulation of T cell apoptotic process (GO:0070233)2.64990025
73regulation of DNA endoreduplication (GO:0032875)2.63332926
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63272829
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63272829
76electron transport chain (GO:0022900)2.63184151
77epithelial cilium movement (GO:0003351)2.63101519
78rhodopsin mediated signaling pathway (GO:0016056)2.62814296
79regulation of nuclear cell cycle DNA replication (GO:0033262)2.62798303
80regulation of T-helper 1 type immune response (GO:0002825)2.62025682
81respiratory electron transport chain (GO:0022904)2.60334198
82ubiquinone metabolic process (GO:0006743)2.60306605
83purine-containing compound salvage (GO:0043101)2.59422919
84pteridine-containing compound biosynthetic process (GO:0042559)2.56996633
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.56974988
86positive regulation of transforming growth factor beta production (GO:0071636)2.56921271
87tolerance induction (GO:0002507)2.56192243
88ncRNA catabolic process (GO:0034661)2.56164089
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55929804
90regulation of mitochondrial translation (GO:0070129)2.53915764
91DNA catabolic process (GO:0006308)2.53529693
92head development (GO:0060322)2.53365479
93DNA catabolic process, endonucleolytic (GO:0000737)2.53359133
94negative regulation of heart rate (GO:0010459)2.53061936
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.52791088
96signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.52791088
97signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.52791088
98GPI anchor metabolic process (GO:0006505)2.52470984
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.51618488
100guanosine-containing compound biosynthetic process (GO:1901070)2.51519544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.06100027
2ZNF274_21170338_ChIP-Seq_K562_Hela4.26721929
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.89792346
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.84152061
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.73703971
6VDR_22108803_ChIP-Seq_LS180_Human3.52167446
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01736146
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84808266
9VDR_23849224_ChIP-Seq_CD4+_Human2.60110149
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55770289
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.45296274
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41320355
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.38265543
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.26779107
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19831696
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19274727
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19199791
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18753912
19MYC_18940864_ChIP-ChIP_HL60_Human2.11410176
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08384377
21FOXP3_21729870_ChIP-Seq_TREG_Human2.07490155
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03530083
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.96861027
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88486196
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85425129
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79879260
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77110388
28ER_23166858_ChIP-Seq_MCF-7_Human1.77017922
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69691588
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65334988
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.59331657
32E2F7_22180533_ChIP-Seq_HELA_Human1.58255683
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56898342
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56527122
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56520915
36ELK1_19687146_ChIP-ChIP_HELA_Human1.51910845
37EWS_26573619_Chip-Seq_HEK293_Human1.43670557
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41977430
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40954299
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40198853
41FUS_26573619_Chip-Seq_HEK293_Human1.39343036
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38044814
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.33881767
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33797982
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32725073
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30643908
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29995009
48ERG_20517297_ChIP-Seq_VCAP_Human1.27890690
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26739168
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24625427
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24258432
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.21164958
53NANOG_19829295_ChIP-Seq_ESCs_Human1.19544757
54SOX2_19829295_ChIP-Seq_ESCs_Human1.19544757
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.17819985
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.17680053
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17680053
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17388273
59HOXB7_26014856_ChIP-Seq_BT474_Human1.16175710
60LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15150436
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13787715
62P300_19829295_ChIP-Seq_ESCs_Human1.11926437
63TP53_22573176_ChIP-Seq_HFKS_Human1.11617894
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11499715
65IRF1_19129219_ChIP-ChIP_H3396_Human1.09637422
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09315648
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09315648
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.08462593
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06072368
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04648780
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.03937080
72NANOG_20526341_ChIP-Seq_ESCs_Human1.03897763
73GABP_19822575_ChIP-Seq_HepG2_Human1.03333306
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02753835
75GBX2_23144817_ChIP-Seq_PC3_Human1.02228333
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.01199046
77NCOR_22424771_ChIP-Seq_293T_Human1.00177948
78IGF1R_20145208_ChIP-Seq_DFB_Human0.99894642
79SOX2_16153702_ChIP-ChIP_HESCs_Human0.98333776
80BCAT_22108803_ChIP-Seq_LS180_Human0.97474635
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97250674
82MYC_19829295_ChIP-Seq_ESCs_Human0.96825269
83DCP1A_22483619_ChIP-Seq_HELA_Human0.96628962
84HTT_18923047_ChIP-ChIP_STHdh_Human0.95573772
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95560449
86MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94725689
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93728293
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.93209676
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92224060
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92074973
91TAF2_19829295_ChIP-Seq_ESCs_Human0.91898502
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90910379
93AR_20517297_ChIP-Seq_VCAP_Human0.89914285
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89161382
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88129092
96CBP_20019798_ChIP-Seq_JUKART_Human0.88129092
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87785119
98CIITA_25753668_ChIP-Seq_RAJI_Human0.86967335
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86102484
100EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85699913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.58863371
2MP0009697_abnormal_copulation3.08976152
3MP0000569_abnormal_digit_pigmentation3.02028953
4MP0005646_abnormal_pituitary_gland3.01757727
5MP0005085_abnormal_gallbladder_physiolo2.58576085
6MP0008007_abnormal_cellular_replicative2.44628803
7MP0001529_abnormal_vocalization2.41749351
8MP0004885_abnormal_endolymph2.37726697
9MP0010094_abnormal_chromosome_stability2.15182528
10MP0005167_abnormal_blood-brain_barrier2.14683036
11MP0003011_delayed_dark_adaptation2.08402379
12MP0008004_abnormal_stomach_pH2.07184845
13MP0008775_abnormal_heart_ventricle2.05569572
14MP0004084_abnormal_cardiac_muscle2.05022796
15MP0003786_premature_aging2.04472208
16MP0008872_abnormal_physiological_respon1.95442443
17MP0001919_abnormal_reproductive_system1.95019944
18MP0003186_abnormal_redox_activity1.88703875
19MP0005551_abnormal_eye_electrophysiolog1.87398087
20MP0005408_hypopigmentation1.85143075
21MP0006035_abnormal_mitochondrial_morpho1.84569171
22MP0003646_muscle_fatigue1.84346008
23MP0002837_dystrophic_cardiac_calcinosis1.81476872
24MP0005075_abnormal_melanosome_morpholog1.80664933
25MP0005084_abnormal_gallbladder_morpholo1.70689484
26MP0003252_abnormal_bile_duct1.64974767
27MP0008789_abnormal_olfactory_epithelium1.64137775
28MP0002102_abnormal_ear_morphology1.63615787
29MP0001293_anophthalmia1.62404130
30MP0008877_abnormal_DNA_methylation1.61507621
31MP0005310_abnormal_salivary_gland1.60308204
32MP0002139_abnormal_hepatobiliary_system1.53359390
33MP0004142_abnormal_muscle_tone1.50704928
34MP0003195_calcinosis1.49626184
35MP0001485_abnormal_pinna_reflex1.41045700
36MP0003806_abnormal_nucleotide_metabolis1.37625581
37MP0001984_abnormal_olfaction1.37602082
38MP0005389_reproductive_system_phenotype1.36477563
39MP0006036_abnormal_mitochondrial_physio1.34775741
40MP0004782_abnormal_surfactant_physiolog1.33177191
41MP0005671_abnormal_response_to1.32362724
42MP0002090_abnormal_vision1.31187073
43MP0002006_tumorigenesis1.30431404
44MP0005174_abnormal_tail_pigmentation1.29053293
45MP0002396_abnormal_hematopoietic_system1.24670078
46MP0001486_abnormal_startle_reflex1.22319654
47MP0004145_abnormal_muscle_electrophysio1.22087258
48MP0006276_abnormal_autonomic_nervous1.22032912
49MP0003718_maternal_effect1.20687570
50MP0002653_abnormal_ependyma_morphology1.20681180
51MP0008875_abnormal_xenobiotic_pharmacok1.20467338
52MP0001501_abnormal_sleep_pattern1.17029288
53MP0003111_abnormal_nucleus_morphology1.16569925
54MP0001440_abnormal_grooming_behavior1.15845777
55MP0009745_abnormal_behavioral_response1.13792680
56MP0000566_synostosis1.11973653
57MP0003763_abnormal_thymus_physiology1.11355729
58MP0002736_abnormal_nociception_after1.10916865
59MP0000613_abnormal_salivary_gland1.09546086
60MP0005394_taste/olfaction_phenotype1.09451866
61MP0005499_abnormal_olfactory_system1.09451866
62MP0004036_abnormal_muscle_relaxation1.06560535
63MP0005253_abnormal_eye_physiology1.03826063
64MP0003866_abnormal_defecation1.03480217
65MP0002210_abnormal_sex_determination1.03254756
66MP0003941_abnormal_skin_development0.98876284
67MP0003077_abnormal_cell_cycle0.98642124
68MP0000013_abnormal_adipose_tissue0.95995055
69MP0002938_white_spotting0.95924996
70MP0008995_early_reproductive_senescence0.93765524
71MP0005083_abnormal_biliary_tract0.93413047
72MP0003698_abnormal_male_reproductive0.93130896
73MP0005645_abnormal_hypothalamus_physiol0.93082961
74MP0002909_abnormal_adrenal_gland0.88790791
75MP0001502_abnormal_circadian_rhythm0.88685942
76MP0008058_abnormal_DNA_repair0.88413559
77MP0000358_abnormal_cell_content/0.87769194
78MP0002277_abnormal_respiratory_mucosa0.87741132
79MP0003045_fibrosis0.86880751
80MP0001905_abnormal_dopamine_level0.85735459
81MP0000372_irregular_coat_pigmentation0.85696968
82MP0005195_abnormal_posterior_eye0.84473326
83MP0000049_abnormal_middle_ear0.84405346
84MP0001764_abnormal_homeostasis0.82930139
85MP0004215_abnormal_myocardial_fiber0.82756607
86MP0001929_abnormal_gametogenesis0.82694091
87MP0005360_urolithiasis0.82540761
88MP0003693_abnormal_embryo_hatching0.81512940
89MP0001666_abnormal_nutrient_absorption0.80662757
90MP0002272_abnormal_nervous_system0.79031414
91MP0004957_abnormal_blastocyst_morpholog0.78583228
92MP0006292_abnormal_olfactory_placode0.77899108
93MP0010368_abnormal_lymphatic_system0.77642033
94MP0001119_abnormal_female_reproductive0.75536696
95MP0000653_abnormal_sex_gland0.74625130
96MP0004019_abnormal_vitamin_homeostasis0.73837204
97MP0002572_abnormal_emotion/affect_behav0.69923193
98MP0005319_abnormal_enzyme/_coenzyme0.69448070
99MP0004085_abnormal_heartbeat0.69017717
100MP0002405_respiratory_system_inflammati0.68584131

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.66207897
2Hepatocellular necrosis (HP:0001404)4.59999986
3IgM deficiency (HP:0002850)4.50590327
4Hepatic necrosis (HP:0002605)4.00584666
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.98868569
6Absent/shortened dynein arms (HP:0200106)3.98868569
7Abnormal respiratory epithelium morphology (HP:0012253)3.58906471
8Abnormal respiratory motile cilium morphology (HP:0005938)3.58906471
9B lymphocytopenia (HP:0010976)3.58346664
10Increased CSF lactate (HP:0002490)3.53831773
11Abnormality of B cell number (HP:0010975)3.43371260
12Retrobulbar optic neuritis (HP:0100654)3.36624694
13Optic neuritis (HP:0100653)3.36624694
14Mitochondrial inheritance (HP:0001427)3.36399144
153-Methylglutaconic aciduria (HP:0003535)3.36374331
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.30830424
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.28423795
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.28423795
19Oligodactyly (hands) (HP:0001180)3.27330827
20Acute necrotizing encephalopathy (HP:0006965)3.04412928
21Abnormal mitochondria in muscle tissue (HP:0008316)3.00283278
22Hypothermia (HP:0002045)2.98315385
23Central scotoma (HP:0000603)2.89546045
24Abnormal ciliary motility (HP:0012262)2.88787086
25Congenital stationary night blindness (HP:0007642)2.87231004
26Orchitis (HP:0100796)2.70071942
27Cerebral hypomyelination (HP:0006808)2.69801836
28Abnormality of lateral ventricle (HP:0030047)2.67829321
29Type I transferrin isoform profile (HP:0003642)2.66512923
30Increased hepatocellular lipid droplets (HP:0006565)2.62981470
31Generalized aminoaciduria (HP:0002909)2.61618968
32Increased serum lactate (HP:0002151)2.57698870
33Microvesicular hepatic steatosis (HP:0001414)2.52808937
34Type II lissencephaly (HP:0007260)2.50242091
35Duplicated collecting system (HP:0000081)2.49022503
36Progressive macrocephaly (HP:0004481)2.47585779
37Keratoconjunctivitis (HP:0001096)2.46687980
38Hypoplasia of the pons (HP:0012110)2.44389284
39Myositis (HP:0100614)2.41192226
40Acute encephalopathy (HP:0006846)2.39400694
41Abnormality of the pons (HP:0007361)2.39236421
42Hypoplastic nipples (HP:0002557)2.35282347
43Ileus (HP:0002595)2.33680145
44Fair hair (HP:0002286)2.33428249
45Hypoplastic pelvis (HP:0008839)2.32340386
46Cerebellar dysplasia (HP:0007033)2.32045142
47Recurrent sinusitis (HP:0011108)2.30821792
48Abnormality of the renal collecting system (HP:0004742)2.29284045
49Lipid accumulation in hepatocytes (HP:0006561)2.26900014
50Increased serum pyruvate (HP:0003542)2.26312701
51Molar tooth sign on MRI (HP:0002419)2.22003837
52Abnormality of midbrain morphology (HP:0002418)2.22003837
53Abnormal hair whorl (HP:0010721)2.21578844
54Scotoma (HP:0000575)2.19334397
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16240296
56Severe combined immunodeficiency (HP:0004430)2.15215999
57Hypoproteinemia (HP:0003075)2.13962942
58Pancreatic cysts (HP:0001737)2.12413163
59IgG deficiency (HP:0004315)2.12215709
60Keratoconjunctivitis sicca (HP:0001097)2.10799573
61Exertional dyspnea (HP:0002875)2.10258336
62Thyroiditis (HP:0100646)2.09973126
63Type 2 muscle fiber atrophy (HP:0003554)2.07237038
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03943673
65Abnormal protein N-linked glycosylation (HP:0012347)2.03943673
66Abnormal protein glycosylation (HP:0012346)2.03943673
67Abnormal glycosylation (HP:0012345)2.03943673
68Progressive microcephaly (HP:0000253)2.03513713
69Nephronophthisis (HP:0000090)2.01469183
70Oligodactyly (HP:0012165)2.00652224
71Abnormal respiratory motile cilium physiology (HP:0012261)2.00461886
72Neoplasm of the oral cavity (HP:0100649)1.98649418
73Increased intramyocellular lipid droplets (HP:0012240)1.98634447
74Split foot (HP:0001839)1.96942892
75Anophthalmia (HP:0000528)1.95014308
76Emotional lability (HP:0000712)1.94852217
77Hypomagnesemia (HP:0002917)1.94143790
78Hypoplastic ischia (HP:0003175)1.93326035
79Optic nerve hypoplasia (HP:0000609)1.93014360
80Pendular nystagmus (HP:0012043)1.92709725
81Aplasia/Hypoplasia of the uvula (HP:0010293)1.92380024
82Chronic hepatic failure (HP:0100626)1.91627139
83Abnormality of glycolysis (HP:0004366)1.90380806
84Muscle fiber atrophy (HP:0100295)1.89199107
85Attenuation of retinal blood vessels (HP:0007843)1.88120081
86CNS demyelination (HP:0007305)1.84846182
87Mesangial abnormality (HP:0001966)1.84769626
88Meckel diverticulum (HP:0002245)1.83559800
89Renal Fanconi syndrome (HP:0001994)1.82761833
90Barrel-shaped chest (HP:0001552)1.82337659
91Abnormality of DNA repair (HP:0003254)1.80819849
92Clubbing of toes (HP:0100760)1.80466522
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79200585
94Cerebral edema (HP:0002181)1.78113786
95Chromsome breakage (HP:0040012)1.77857343
96Abnormality of the ileum (HP:0001549)1.77239159
97Aplasia/hypoplasia of the uterus (HP:0008684)1.76108614
98Respiratory failure (HP:0002878)1.75790450
99Abnormal rod and cone electroretinograms (HP:0008323)1.75287598
100Optic disc pallor (HP:0000543)1.74794998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.71137643
2TRIM283.24298798
3PINK13.11170833
4NEK13.08707456
5BMPR1B2.86038971
6TAOK32.86007442
7ZAK2.83701615
8TSSK62.80301240
9GRK72.70997775
10NEK92.22089521
11MAP3K132.20053160
12GRK12.19542472
13BRSK22.16731472
14TLK12.11949271
15BUB11.97449802
16CSNK1G21.81020478
17WNK41.75029560
18WEE11.70888198
19CDC71.69935250
20WNK31.67430374
21ADRBK21.66129870
22CSNK1G31.63346107
23CSNK1G11.60793448
24MAP3K121.56632609
25VRK21.56474546
26DYRK21.52552806
27TEC1.51363173
28PLK31.40650454
29TNIK1.39390175
30STK161.37723002
31TAF11.36911077
32CSNK1A1L1.35430171
33KDR1.30975981
34PRKCI1.26155717
35ALK1.23957162
36IKBKE1.19872794
37STK391.17713792
38FRK1.16140959
39NLK1.14752880
40SRPK11.12583298
41IRAK11.09274624
42OXSR11.03873275
43PASK1.01553127
44MINK10.97463473
45KSR10.96775646
46CAMKK20.92240480
47BCKDK0.89719458
48TXK0.87770200
49ACVR1B0.84890764
50TBK10.84063104
51TGFBR10.83639370
52DAPK10.79239237
53ADRBK10.78890408
54SYK0.78724104
55NUAK10.78429076
56MAPK150.76218072
57TTK0.75640007
58VRK10.74970981
59MAP3K90.72032767
60BRSK10.68177332
61LIMK10.66395034
62ARAF0.66330605
63BCR0.66221575
64EPHB10.65753321
65PTK2B0.61262450
66FES0.60403486
67PIK3CG0.59709105
68ATR0.58898071
69RPS6KA50.58321679
70CHEK20.57681745
71ITK0.56598513
72FER0.50821722
73EIF2AK30.49903535
74PLK10.48328763
75BTK0.46761123
76MARK30.45809221
77MAP3K70.44522375
78CSK0.43537078
79EPHA30.43245379
80MAP4K10.40918735
81ATM0.40828364
82MAPK130.40547517
83AURKB0.40036936
84PBK0.39781657
85LCK0.38345794
86GRK50.38270212
87DAPK20.37781100
88PHKG10.37337851
89PHKG20.37337851
90MKNK20.37294977
91INSRR0.37086570
92MAP2K60.36843536
93PRKCQ0.36563773
94CCNB10.36561252
95PKN10.34146553
96CSNK1A10.30772813
97PRKCG0.29042474
98MAP3K110.29022222
99CSNK1D0.26490459
100MKNK10.26272579

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.96219210
2Oxidative phosphorylation_Homo sapiens_hsa001903.04074068
3Phototransduction_Homo sapiens_hsa047442.94228401
4Primary immunodeficiency_Homo sapiens_hsa053402.88064890
5One carbon pool by folate_Homo sapiens_hsa006702.68883448
6Protein export_Homo sapiens_hsa030602.68356344
7Parkinsons disease_Homo sapiens_hsa050122.67132950
8Homologous recombination_Homo sapiens_hsa034402.64661222
9RNA polymerase_Homo sapiens_hsa030202.46661488
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00161101
11Huntingtons disease_Homo sapiens_hsa050161.79508392
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77748491
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75174125
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70640016
15RNA degradation_Homo sapiens_hsa030181.70353370
16Basal transcription factors_Homo sapiens_hsa030221.69589171
17Alzheimers disease_Homo sapiens_hsa050101.66037668
18Selenocompound metabolism_Homo sapiens_hsa004501.62776764
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57434652
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.56832765
21Ribosome_Homo sapiens_hsa030101.55365576
22Linoleic acid metabolism_Homo sapiens_hsa005911.51816529
23Asthma_Homo sapiens_hsa053101.51288571
24Ether lipid metabolism_Homo sapiens_hsa005651.46870547
25Regulation of autophagy_Homo sapiens_hsa041401.44662035
26Fanconi anemia pathway_Homo sapiens_hsa034601.42900882
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37485004
28RNA transport_Homo sapiens_hsa030131.36376735
29Allograft rejection_Homo sapiens_hsa053301.34174657
30Purine metabolism_Homo sapiens_hsa002301.33820356
31Non-homologous end-joining_Homo sapiens_hsa034501.31590588
32Steroid biosynthesis_Homo sapiens_hsa001001.29815531
33Type I diabetes mellitus_Homo sapiens_hsa049401.29499032
34Nucleotide excision repair_Homo sapiens_hsa034201.28949292
35Autoimmune thyroid disease_Homo sapiens_hsa053201.27023276
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26683338
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.26271788
38Base excision repair_Homo sapiens_hsa034101.26029396
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.22780704
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20524315
41Nitrogen metabolism_Homo sapiens_hsa009101.20288048
42Caffeine metabolism_Homo sapiens_hsa002321.17188170
43Antigen processing and presentation_Homo sapiens_hsa046121.16135660
44Graft-versus-host disease_Homo sapiens_hsa053321.14609990
45Nicotine addiction_Homo sapiens_hsa050331.14437648
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13928833
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12159939
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07498441
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05572503
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.04429875
51DNA replication_Homo sapiens_hsa030300.99618302
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99359524
53Spliceosome_Homo sapiens_hsa030400.97477357
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93582883
55Chemical carcinogenesis_Homo sapiens_hsa052040.92511720
56Glutathione metabolism_Homo sapiens_hsa004800.90440292
57Cardiac muscle contraction_Homo sapiens_hsa042600.89444842
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88930822
59Pyrimidine metabolism_Homo sapiens_hsa002400.88587349
60Fat digestion and absorption_Homo sapiens_hsa049750.83654124
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82914778
62Sulfur metabolism_Homo sapiens_hsa009200.80715221
63Tryptophan metabolism_Homo sapiens_hsa003800.73651023
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72973035
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69119385
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67556945
67Systemic lupus erythematosus_Homo sapiens_hsa053220.65203157
68Butanoate metabolism_Homo sapiens_hsa006500.64319909
69Circadian rhythm_Homo sapiens_hsa047100.64252826
70Fatty acid elongation_Homo sapiens_hsa000620.64062071
71Metabolic pathways_Homo sapiens_hsa011000.63155316
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62180143
73Retinol metabolism_Homo sapiens_hsa008300.60740907
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58569134
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58550776
76Mineral absorption_Homo sapiens_hsa049780.55269251
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55113654
78Olfactory transduction_Homo sapiens_hsa047400.55021361
79Serotonergic synapse_Homo sapiens_hsa047260.53142165
80Propanoate metabolism_Homo sapiens_hsa006400.52642782
81Morphine addiction_Homo sapiens_hsa050320.50050965
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49530768
83Arachidonic acid metabolism_Homo sapiens_hsa005900.48023839
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46756161
85Viral myocarditis_Homo sapiens_hsa054160.45437698
86GABAergic synapse_Homo sapiens_hsa047270.45142556
87Epstein-Barr virus infection_Homo sapiens_hsa051690.43993615
88Peroxisome_Homo sapiens_hsa041460.43442832
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.41666618
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39082068
91Hematopoietic cell lineage_Homo sapiens_hsa046400.38575181
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.38245373
93Rheumatoid arthritis_Homo sapiens_hsa053230.37122545
94p53 signaling pathway_Homo sapiens_hsa041150.37017960
95Staphylococcus aureus infection_Homo sapiens_hsa051500.36664093
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36068251
97Collecting duct acid secretion_Homo sapiens_hsa049660.33591523
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32928568
99Tyrosine metabolism_Homo sapiens_hsa003500.32504428
100ABC transporters_Homo sapiens_hsa020100.31563436

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