PSMD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.93712735
2protein maturation by protein folding (GO:0022417)4.68130165
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.28079147
4ATP synthesis coupled proton transport (GO:0015986)4.28079147
5regulation of mitochondrial translation (GO:0070129)4.26376271
6chaperone-mediated protein transport (GO:0072321)4.25876977
7formation of translation preinitiation complex (GO:0001731)4.23908541
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.19236086
9protein targeting to mitochondrion (GO:0006626)3.97827959
10respiratory electron transport chain (GO:0022904)3.97211313
11electron transport chain (GO:0022900)3.85275603
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.83888281
13maturation of SSU-rRNA (GO:0030490)3.78954865
14ribosomal small subunit assembly (GO:0000028)3.75257123
15viral transcription (GO:0019083)3.72502946
16establishment of protein localization to mitochondrion (GO:0072655)3.70011162
17Golgi transport vesicle coating (GO:0048200)3.66923567
18COPI coating of Golgi vesicle (GO:0048205)3.66923567
19translational termination (GO:0006415)3.66869411
20DNA deamination (GO:0045006)3.64600753
21establishment of integrated proviral latency (GO:0075713)3.59272180
22establishment of viral latency (GO:0019043)3.55632596
23protein localization to mitochondrion (GO:0070585)3.53727309
24termination of RNA polymerase III transcription (GO:0006386)3.52890236
25transcription elongation from RNA polymerase III promoter (GO:0006385)3.52890236
26ribosomal large subunit biogenesis (GO:0042273)3.50511709
27proteasome assembly (GO:0043248)3.49908406
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.49742492
29purine nucleobase biosynthetic process (GO:0009113)3.48948960
30translational elongation (GO:0006414)3.47785768
31translational initiation (GO:0006413)3.47761367
32oxidative phosphorylation (GO:0006119)3.47090783
33* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44719732
34nucleobase biosynthetic process (GO:0046112)3.43643061
35guanosine-containing compound biosynthetic process (GO:1901070)3.42414498
36nuclear envelope reassembly (GO:0031468)3.40918840
37mitotic nuclear envelope reassembly (GO:0007084)3.40918840
38GDP-mannose metabolic process (GO:0019673)3.34195536
39ribosome assembly (GO:0042255)3.33034372
40cellular component biogenesis (GO:0044085)3.30749213
41NADH metabolic process (GO:0006734)3.30018750
42* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29647704
43pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.28502012
44* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27400912
45* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26515582
46folic acid metabolic process (GO:0046655)3.25087462
47proline biosynthetic process (GO:0006561)3.23289207
48* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22297340
49* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.21939891
50metallo-sulfur cluster assembly (GO:0031163)3.21270853
51iron-sulfur cluster assembly (GO:0016226)3.21270853
52peptidyl-arginine omega-N-methylation (GO:0035247)3.21269474
53folic acid-containing compound biosynthetic process (GO:0009396)3.19943892
54UTP biosynthetic process (GO:0006228)3.19326963
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19294297
56DNA strand elongation involved in DNA replication (GO:0006271)3.15153161
57GTP biosynthetic process (GO:0006183)3.14928578
58* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14386843
59* negative regulation of ligase activity (GO:0051352)3.14386843
60pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.14169934
61protein targeting to ER (GO:0045047)3.09167024
62* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09088753
63tricarboxylic acid cycle (GO:0006099)3.08996720
642-deoxyribonucleotide biosynthetic process (GO:0009265)3.08213594
65deoxyribose phosphate biosynthetic process (GO:0046385)3.08213594
66ribosomal small subunit biogenesis (GO:0042274)3.08066213
67regulation of translational fidelity (GO:0006450)3.07626315
68pseudouridine synthesis (GO:0001522)3.06612261
69cotranslational protein targeting to membrane (GO:0006613)3.05877949
70maturation of 5.8S rRNA (GO:0000460)3.03707242
71* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02912580
72* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02912580
73* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00659722
74* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00659722
75* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00659722
76* regulation of cellular amino acid metabolic process (GO:0006521)3.00126996
77pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.98439549
78nucleobase-containing small molecule interconversion (GO:0015949)2.97974927
79* signal transduction involved in DNA damage checkpoint (GO:0072422)2.97662136
80* signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97662136
81viral life cycle (GO:0019058)2.97216600
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.96985054
83inner mitochondrial membrane organization (GO:0007007)2.96548169
84negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.95573787
85transcription-coupled nucleotide-excision repair (GO:0006283)2.94637687
86* positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94157566
87protein localization to endoplasmic reticulum (GO:0070972)2.93708704
88DNA strand elongation (GO:0022616)2.93291216
89IMP biosynthetic process (GO:0006188)2.92321542
90* signal transduction involved in cell cycle checkpoint (GO:0072395)2.92220069
91establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91773936
92ribonucleoprotein complex biogenesis (GO:0022613)2.90409027
93cellular protein complex disassembly (GO:0043624)2.87286019
94translation (GO:0006412)2.82931662
95telomere maintenance via semi-conservative replication (GO:0032201)2.82504655
96* positive regulation of ligase activity (GO:0051351)2.79776255
97pentose-phosphate shunt (GO:0006098)2.78826152
98DNA replication initiation (GO:0006270)2.78785532
99mitotic nuclear envelope disassembly (GO:0007077)2.75725537
100protein localization to kinetochore (GO:0034501)2.74417625
101ribosome biogenesis (GO:0042254)2.72990252
102folic acid transport (GO:0015884)2.72298137
103IMP metabolic process (GO:0046040)2.68908332
104regulation of protein heterodimerization activity (GO:0043497)2.68727635
105regulation of translational termination (GO:0006449)2.68124228
106Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66039599
107* positive regulation of cell cycle arrest (GO:0071158)2.64102602
108* regulation of ubiquitin-protein transferase activity (GO:0051438)2.61618740
109DNA replication checkpoint (GO:0000076)2.59445475
110* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.59100918
111nucleoside salvage (GO:0043174)2.57057384
112membrane disassembly (GO:0030397)2.56719360
113nuclear envelope disassembly (GO:0051081)2.56719360
114protein complex disassembly (GO:0043241)2.56351253
115telomere maintenance via recombination (GO:0000722)2.55239771
116natural killer cell mediated immunity (GO:0002228)2.54213170
117natural killer cell mediated cytotoxicity (GO:0042267)2.54213170
118protein localization to chromosome, centromeric region (GO:0071459)2.53930917
119DNA replication-dependent nucleosome assembly (GO:0006335)2.53179679
120DNA replication-dependent nucleosome organization (GO:0034723)2.53179679
121spliceosomal snRNP assembly (GO:0000387)2.52739382
122mitotic metaphase plate congression (GO:0007080)2.51992441
123* G1/S transition of mitotic cell cycle (GO:0000082)2.51777560
124* cell cycle G1/S phase transition (GO:0044843)2.51777560
125* regulation of ligase activity (GO:0051340)2.50978335
126NADPH regeneration (GO:0006740)2.48640912
127rRNA processing (GO:0006364)2.48189882
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.47623841
129purine nucleotide salvage (GO:0032261)2.45875902
130macromolecular complex disassembly (GO:0032984)2.43654040
131DNA unwinding involved in DNA replication (GO:0006268)2.43619320
132T cell apoptotic process (GO:0070231)2.43249371
133activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.42429403
134AMP metabolic process (GO:0046033)2.42423856
135rRNA metabolic process (GO:0016072)2.40236977
136deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.39296491
137protein deneddylation (GO:0000338)2.35067027
138chaperone-mediated protein complex assembly (GO:0051131)2.33627309
139mitotic recombination (GO:0006312)2.32784982
140interferon-gamma secretion (GO:0072643)2.32132508
141glycine metabolic process (GO:0006544)2.31835698
142cullin deneddylation (GO:0010388)2.31472459
143galactose catabolic process (GO:0019388)2.27951559
144* DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.27302604
145histone-serine phosphorylation (GO:0035404)2.27278365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.65800747
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92796942
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.47906197
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.58673535
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52673789
6* ETS1_20019798_ChIP-Seq_JURKAT_Human2.48480618
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47974124
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45015735
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.44066394
10* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38574526
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.36322902
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36297820
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25487403
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.16041271
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15053976
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05845955
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03334429
18XRN2_22483619_ChIP-Seq_HELA_Human2.02689803
19E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95592683
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94926037
21DCP1A_22483619_ChIP-Seq_HELA_Human1.89821648
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89245451
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85162607
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.83973443
25* VDR_23849224_ChIP-Seq_CD4+_Human1.78984786
26GABP_19822575_ChIP-Seq_HepG2_Human1.69537372
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68768277
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58947508
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57013295
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56158251
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54885421
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53844094
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53454512
34AR_21909140_ChIP-Seq_LNCAP_Human1.52400275
35MYC_22102868_ChIP-Seq_BL_Human1.48539081
36FOXP3_21729870_ChIP-Seq_TREG_Human1.47476238
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47442874
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46769130
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46417788
40TTF2_22483619_ChIP-Seq_HELA_Human1.41318569
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40690726
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40265081
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40116297
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38699664
45TFEB_21752829_ChIP-Seq_HELA_Human1.38582832
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36708011
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35525513
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.34936078
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.34829018
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34550004
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33566164
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32984513
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.32961662
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31762830
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31455992
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30105824
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29925742
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29609857
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28337445
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28176668
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26752967
62* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26114369
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25835931
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25150230
65* SRF_21415370_ChIP-Seq_HL-1_Mouse1.25033228
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24233797
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24041368
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23991846
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23772584
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23612383
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23089710
72* ELK1_19687146_ChIP-ChIP_HELA_Human1.22650089
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22284353
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21611619
75* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21603393
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21105394
77KDM5A_27292631_Chip-Seq_BREAST_Human1.20565822
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.20307688
79VDR_21846776_ChIP-Seq_THP-1_Human1.18300542
80* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16306239
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16067631
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.16016517
83ATF3_27146783_Chip-Seq_COLON_Human1.15389885
84SPI1_23547873_ChIP-Seq_NB4_Human1.15326496
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14440186
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13025304
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12612818
88* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12368469
89* TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11359431
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10825751
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10794049
92* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10211029
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09906701
94* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09371798
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.09107618
96ZNF263_19887448_ChIP-Seq_K562_Human1.08334805
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07355205
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06934487
99CLOCK_20551151_ChIP-Seq_293T_Human1.06707149
100* ELK1_22589737_ChIP-Seq_MCF10A_Human1.06574837
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06347325
102* FOXP1_21924763_ChIP-Seq_HESCs_Human1.05485104
103MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05435152
104* CIITA_25753668_ChIP-Seq_RAJI_Human1.03722622
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02352031
106HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99766258
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99692837
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99673777
109* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99636011
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98762306
111* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97313585
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96309474
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96215919
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95909019
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.95732987
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93720201
117LXR_22292898_ChIP-Seq_THP-1_Human0.93618620
118* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93044711
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92558020
120RACK7_27058665_Chip-Seq_MCF-7_Human0.88774374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.60950113
2MP0004957_abnormal_blastocyst_morpholog2.80708467
3MP0009379_abnormal_foot_pigmentation2.72193413
4MP0009840_abnormal_foam_cell2.72060856
5MP0006036_abnormal_mitochondrial_physio2.66445522
6MP0010352_gastrointestinal_tract_polyps2.49470160
7MP0003705_abnormal_hypodermis_morpholog2.43437737
8MP0006035_abnormal_mitochondrial_morpho2.40652910
9MP0004233_abnormal_muscle_weight2.40019067
10MP0003806_abnormal_nucleotide_metabolis2.37413541
11MP0003111_abnormal_nucleus_morphology2.33520053
12MP0002877_abnormal_melanocyte_morpholog2.29354437
13MP0003077_abnormal_cell_cycle2.11530080
14MP0004858_abnormal_nervous_system1.95601110
15MP0008438_abnormal_cutaneous_collagen1.93122569
16MP0005058_abnormal_lysosome_morphology1.91173261
17MP0008260_abnormal_autophagy1.88880067
18MP0000749_muscle_degeneration1.87637689
19MP0003436_decreased_susceptibility_to1.86706014
20MP0010094_abnormal_chromosome_stability1.81293959
21MP0003186_abnormal_redox_activity1.81279881
22MP0001727_abnormal_embryo_implantation1.80090216
23MP0005623_abnormal_meninges_morphology1.78958107
24MP0010307_abnormal_tumor_latency1.72671978
25MP0008007_abnormal_cellular_replicative1.72457569
26MP0003566_abnormal_cell_adhesion1.65684266
27MP0009333_abnormal_splenocyte_physiolog1.65366603
28MP0004185_abnormal_adipocyte_glucose1.64962862
29MP0000858_altered_metastatic_potential1.62315567
30MP0003941_abnormal_skin_development1.57758643
31MP0005023_abnormal_wound_healing1.56243866
32MP0005330_cardiomyopathy1.55437888
33MP0008932_abnormal_embryonic_tissue1.51265127
34MP0001661_extended_life_span1.47172550
35MP0001730_embryonic_growth_arrest1.44063975
36MP0000750_abnormal_muscle_regeneration1.43724702
37MP0006054_spinal_hemorrhage1.42648439
38MP0001853_heart_inflammation1.39600884
39MP0000678_abnormal_parathyroid_gland1.38559274
40MP0000490_abnormal_crypts_of1.35852198
41MP0000751_myopathy1.34429462
42MP0003191_abnormal_cellular_cholesterol1.34187444
43MP0001835_abnormal_antigen_presentation1.33793586
44MP0003315_abnormal_perineum_morphology1.31634138
45MP0000350_abnormal_cell_proliferation1.29506073
46MP0005275_abnormal_skin_tensile1.28174541
47MP0000537_abnormal_urethra_morphology1.27157008
48MP0000747_muscle_weakness1.25377900
49MP0000358_abnormal_cell_content/1.21487882
50MP0009785_altered_susceptibility_to1.20429720
51MP0003123_paternal_imprinting1.18735853
52MP0000759_abnormal_skeletal_muscle1.17857128
53MP0004947_skin_inflammation1.17297424
54MP0003303_peritoneal_inflammation1.16666500
55MP0002019_abnormal_tumor_incidence1.13087256
56MP0000003_abnormal_adipose_tissue1.12346382
57MP0001545_abnormal_hematopoietic_system1.11701676
58MP0005397_hematopoietic_system_phenotyp1.11701676
59MP0000685_abnormal_immune_system1.10710981
60MP0003221_abnormal_cardiomyocyte_apopto1.10094138
61MP0005257_abnormal_intraocular_pressure1.09229989
62MP0001542_abnormal_bone_strength1.08949416
63MP0001881_abnormal_mammary_gland1.08915641
64MP0003448_altered_tumor_morphology1.08907146
65MP0003011_delayed_dark_adaptation1.07480816
66MP0000343_altered_response_to1.05849855
67MP0001764_abnormal_homeostasis1.05453019
68MP0009697_abnormal_copulation1.03218338
69MP0002080_prenatal_lethality1.03052881
70MP0001533_abnormal_skeleton_physiology1.02561495
71MP0006082_CNS_inflammation1.01772063
72MP0002269_muscular_atrophy1.01430436
73MP0003950_abnormal_plasma_membrane1.00123027
74MP0002452_abnormal_antigen_presenting0.98565603
75MP0001697_abnormal_embryo_size0.98243489
76MP0003718_maternal_effect0.97896206
77MP0003786_premature_aging0.97538224
78MP0005025_abnormal_response_to0.96829149
79MP0002419_abnormal_innate_immunity0.96571420
80MP0004808_abnormal_hematopoietic_stem0.96284482
81MP0004272_abnormal_basement_membrane0.95582146
82MP0000598_abnormal_liver_morphology0.95101580
83MP0002396_abnormal_hematopoietic_system0.94537916
84MP0003385_abnormal_body_wall0.94487014
85MP0001243_abnormal_dermal_layer0.94257592
86MP0001672_abnormal_embryogenesis/_devel0.94063016
87MP0005380_embryogenesis_phenotype0.94063016
88MP0010234_abnormal_vibrissa_follicle0.94045182
89MP0000313_abnormal_cell_death0.93636039
90MP0003984_embryonic_growth_retardation0.93474172
91MP0002405_respiratory_system_inflammati0.93390711
92MP0002088_abnormal_embryonic_growth/wei0.92722926
93MP0005000_abnormal_immune_tolerance0.92580387
94MP0008058_abnormal_DNA_repair0.92453452
95MP0009053_abnormal_anal_canal0.92055520
96MP0002722_abnormal_immune_system0.91643335
97MP0000689_abnormal_spleen_morphology0.91536855
98MP0000372_irregular_coat_pigmentation0.91133361
99MP0008789_abnormal_olfactory_epithelium0.90941118
100MP0005501_abnormal_skin_physiology0.90859508
101MP0005076_abnormal_cell_differentiation0.90759214
102MP0002234_abnormal_pharynx_morphology0.90203105
103MP0005319_abnormal_enzyme/_coenzyme0.90197865
104MP0008469_abnormal_protein_level0.89659705
105MP0001529_abnormal_vocalization0.89609284
106MP0003279_aneurysm0.88659947
107MP0002148_abnormal_hypersensitivity_rea0.87351687
108MP0005408_hypopigmentation0.86625202
109MP0003453_abnormal_keratinocyte_physiol0.86246292
110MP0000609_abnormal_liver_physiology0.86063014
111MP0002837_dystrophic_cardiac_calcinosis0.85825145
112MP0002163_abnormal_gland_morphology0.85523443
113MP0002796_impaired_skin_barrier0.85396953
114MP0001845_abnormal_inflammatory_respons0.85158865
115MP0002398_abnormal_bone_marrow0.85066661
116MP0005464_abnormal_platelet_physiology0.84318710
117MP0001800_abnormal_humoral_immune0.83181253
118MP0002429_abnormal_blood_cell0.83006943
119MP0002085_abnormal_embryonic_tissue0.82872945
120MP0010030_abnormal_orbit_morphology0.82676693
121MP0000733_abnormal_muscle_development0.81792872
122MP0005083_abnormal_biliary_tract0.81550454
123MP0002723_abnormal_immune_serum0.81270280
124MP0002139_abnormal_hepatobiliary_system0.80023109
125MP0001819_abnormal_immune_cell0.79264451
126MP0002086_abnormal_extraembryonic_tissu0.78790189
127MP0000049_abnormal_middle_ear0.78762466
128MP0002420_abnormal_adaptive_immunity0.78200597
129MP0005384_cellular_phenotype0.77668635
130MP0009672_abnormal_birth_weight0.77472616
131MP0005670_abnormal_white_adipose0.77320474
132MP0004197_abnormal_fetal_growth/weight/0.77264184
133MP0002060_abnormal_skin_morphology0.77169700
134MP0001849_ear_inflammation0.75235530
135MP0001915_intracranial_hemorrhage0.75037990
136MP0001958_emphysema0.74816632
137MP0005451_abnormal_body_composition0.74701416
138MP0010155_abnormal_intestine_physiology0.74674623
139MP0005360_urolithiasis0.74575338
140MP0004087_abnormal_muscle_fiber0.74259368
141MP0005375_adipose_tissue_phenotype0.74171839
142MP0002210_abnormal_sex_determination0.72811469
143MP0005165_increased_susceptibility_to0.72528251
144MP0001346_abnormal_lacrimal_gland0.72519181
145MP0005584_abnormal_enzyme/coenzyme_acti0.71696764
146MP0002970_abnormal_white_adipose0.71049307
147MP0002160_abnormal_reproductive_system0.71011861
148MP0005332_abnormal_amino_acid0.70492753
149MP0000762_abnormal_tongue_morphology0.70458181
150MP0005666_abnormal_adipose_tissue0.68015456
151MP0002177_abnormal_outer_ear0.67401014
152MP0000013_abnormal_adipose_tissue0.66611536

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.08081426
2Acute necrotizing encephalopathy (HP:0006965)4.89791753
3Acute encephalopathy (HP:0006846)4.43835274
4Mitochondrial inheritance (HP:0001427)4.19438069
5Hepatocellular necrosis (HP:0001404)3.99331392
6Increased CSF lactate (HP:0002490)3.93623408
7Progressive macrocephaly (HP:0004481)3.71686851
8Hepatic necrosis (HP:0002605)3.71014224
9Increased intramyocellular lipid droplets (HP:0012240)3.67975918
10Cerebral edema (HP:0002181)3.43032253
11Multiple enchondromatosis (HP:0005701)3.37805463
12Increased muscle lipid content (HP:0009058)3.37777609
13Exercise intolerance (HP:0003546)3.31966251
14Lactic acidosis (HP:0003128)3.28910763
15Abnormal gallbladder physiology (HP:0012438)3.19579210
16Cholecystitis (HP:0001082)3.19579210
17Increased serum lactate (HP:0002151)3.15194058
18Trismus (HP:0000211)3.14046710
19Microvesicular hepatic steatosis (HP:0001414)3.13806308
20Ragged-red muscle fibers (HP:0003200)3.09601035
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.02535813
22Premature rupture of membranes (HP:0001788)2.99826189
23Increased hepatocellular lipid droplets (HP:0006565)2.99128250
24Abnormality of the anterior horn cell (HP:0006802)2.97469353
25Degeneration of anterior horn cells (HP:0002398)2.97469353
26Reticulocytopenia (HP:0001896)2.92478374
27Respiratory failure (HP:0002878)2.89429553
28Renal Fanconi syndrome (HP:0001994)2.89366941
29Type I transferrin isoform profile (HP:0003642)2.86362311
30Lipid accumulation in hepatocytes (HP:0006561)2.84653066
31Abnormality of cells of the erythroid lineage (HP:0012130)2.78204202
32Protrusio acetabuli (HP:0003179)2.72872504
33Rhabdomyolysis (HP:0003201)2.62105968
34Nausea (HP:0002018)2.59058317
35Hypokinesia (HP:0002375)2.58729356
36Testicular atrophy (HP:0000029)2.58606057
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57692045
38Vacuolated lymphocytes (HP:0001922)2.57433542
39Breast hypoplasia (HP:0003187)2.54046708
40Abnormal protein N-linked glycosylation (HP:0012347)2.51092081
41Abnormal protein glycosylation (HP:0012346)2.51092081
42Abnormal glycosylation (HP:0012345)2.51092081
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51092081
44Poor head control (HP:0002421)2.50259785
45Ulnar deviation of the wrist (HP:0003049)2.49862221
46Vertebral compression fractures (HP:0002953)2.49515799
47Rough bone trabeculation (HP:0100670)2.46993475
48Abnormal number of erythroid precursors (HP:0012131)2.46032736
49Oral leukoplakia (HP:0002745)2.44043263
503-Methylglutaconic aciduria (HP:0003535)2.41550449
51Aplastic anemia (HP:0001915)2.35814289
52Cerebral hypomyelination (HP:0006808)2.35288330
53Emotional lability (HP:0000712)2.32854417
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31057365
55Cervical subluxation (HP:0003308)2.30866437
56Personality changes (HP:0000751)2.26132621
57Microretrognathia (HP:0000308)2.26101304
58Carpal bone hypoplasia (HP:0001498)2.23202111
59Calcaneovalgus deformity (HP:0001848)2.22867167
60Macrocytic anemia (HP:0001972)2.22260737
61Abnormality of the calcaneus (HP:0008364)2.21679598
62Redundant skin (HP:0001582)2.20033766
63Difficulty climbing stairs (HP:0003551)2.13470802
64Pallor (HP:0000980)2.12272196
65Upper limb muscle weakness (HP:0003484)2.11094756
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.08722369
67Eczematoid dermatitis (HP:0000976)2.08555900
68Selective tooth agenesis (HP:0001592)2.08437567
69Elevated erythrocyte sedimentation rate (HP:0003565)2.08220873
70Myopathic facies (HP:0002058)2.06648405
71Pancytopenia (HP:0001876)2.06499453
72Recurrent abscess formation (HP:0002722)2.05781242
73Deformed tarsal bones (HP:0008119)2.04771365
74Increased cerebral lipofuscin (HP:0011813)2.04707006
75Leukodystrophy (HP:0002415)2.03305235
76Lethargy (HP:0001254)2.03272912
77Abnormal cartilage morphology (HP:0002763)2.02148043
78Nemaline bodies (HP:0003798)2.00956247
79Muscle fiber inclusion bodies (HP:0100299)1.99922861
80Thrombocytosis (HP:0001894)1.97604702
81Petechiae (HP:0000967)1.96808032
82Respiratory difficulties (HP:0002880)1.96724583
83Opisthotonus (HP:0002179)1.95546602
84Reduced antithrombin III activity (HP:0001976)1.95055562
85CNS demyelination (HP:0007305)1.94770243
86Abnormality of the tricuspid valve (HP:0001702)1.93099267
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92536770
88Pustule (HP:0200039)1.92502819
89Recurrent gram-negative bacterial infections (HP:0005420)1.92199478
90Cutaneous melanoma (HP:0012056)1.91507312
91Recurrent bacterial skin infections (HP:0005406)1.90980442
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90931466
93Dicarboxylic aciduria (HP:0003215)1.90931466
94Abnormality of the umbilical cord (HP:0010881)1.89973465
95Generalized aminoaciduria (HP:0002909)1.89487353
96Distal lower limb amyotrophy (HP:0008944)1.89220633
97Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88924936
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88924936
99Osteolytic defects of the hand bones (HP:0009699)1.88543742
100Osteolytic defects of the phalanges of the hand (HP:0009771)1.88543742
101Hyperthyroidism (HP:0000836)1.88529090
102Birth length less than 3rd percentile (HP:0003561)1.88507994
103Cholelithiasis (HP:0001081)1.88103475
104Abnormal trabecular bone morphology (HP:0100671)1.87338079
105Generalized amyotrophy (HP:0003700)1.86697605
106Secondary amenorrhea (HP:0000869)1.86595991
107Peritonitis (HP:0002586)1.86064226
108Broad distal phalanx of finger (HP:0009836)1.85390819
109Beaking of vertebral bodies (HP:0004568)1.85275288
110Premature ovarian failure (HP:0008209)1.83791899
111Distal arthrogryposis (HP:0005684)1.83470031
112Agnosia (HP:0010524)1.83288740
113Increased serum ferritin (HP:0003281)1.82997929
114Esophageal neoplasm (HP:0100751)1.82930738
115Neoplasm of head and neck (HP:0012288)1.82930738
116Abnormality of macrophages (HP:0004311)1.82000961
117Mucosal telangiectasiae (HP:0100579)1.81831817
118Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81130524
119Abnormality of placental membranes (HP:0011409)1.80398723
120Amniotic constriction ring (HP:0009775)1.80398723
121Congenital ichthyosiform erythroderma (HP:0007431)1.79160154
122Short nail (HP:0001799)1.78810800
123X-linked dominant inheritance (HP:0001423)1.77643589
124Abnormality of the fetal cardiovascular system (HP:0010948)1.77622531
125Abnormal umbilical cord blood vessels (HP:0011403)1.77622531
126Single umbilical artery (HP:0001195)1.77622531
127Entropion (HP:0000621)1.77521580
128Progressive muscle weakness (HP:0003323)1.77043802
129Hypobetalipoproteinemia (HP:0003563)1.76127766
130Abnormality of pyrimidine metabolism (HP:0004353)1.75596486
131Hypertensive crisis (HP:0100735)1.75447605
132Increased density of long bones (HP:0006392)1.75306099
133Optic disc pallor (HP:0000543)1.75079460
134Increased connective tissue (HP:0009025)1.73944556
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.73114160
136Sparse eyelashes (HP:0000653)1.72585183
137Hand muscle atrophy (HP:0009130)1.72409088
138Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72220801
139Spastic diplegia (HP:0001264)1.72001928
140Distal lower limb muscle weakness (HP:0009053)1.71893794
141Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71639884
142Truncus arteriosus (HP:0001660)1.71056070
143Fasciculations (HP:0002380)1.70954324
144Abnormal hemoglobin (HP:0011902)1.70911778
145Joint stiffness (HP:0001387)1.70909178
146Muscle fiber atrophy (HP:0100295)1.70111680
147Nonimmune hydrops fetalis (HP:0001790)1.70044143
148Abnormality of the Achilles tendon (HP:0005109)1.69451303
149Abnormality of reticulocytes (HP:0004312)1.69119633
150Dysostosis multiplex (HP:0000943)1.68942567
151Angiofibromas (HP:0010615)1.66243154
152Adenoma sebaceum (HP:0009720)1.66243154
153Xanthomatosis (HP:0000991)1.66192983
154Abnormality of subcutaneous fat tissue (HP:0001001)1.62478159
155Atrophy/Degeneration involving motor neurons (HP:0007373)1.61594426
156Interstitial pulmonary disease (HP:0006530)1.61040398
157Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.60897027
158Abnormality of alanine metabolism (HP:0010916)1.60897027
159Hyperalaninemia (HP:0003348)1.60897027
160Abnormality of the motor neurons (HP:0002450)1.58385793
161Abnormal neuron morphology (HP:0012757)1.58385793
162Abnormalities of placenta or umbilical cord (HP:0001194)1.56570857
163Pelvic girdle muscle weakness (HP:0003749)1.56171057
164Achilles tendon contracture (HP:0001771)1.55915840
165Systemic lupus erythematosus (HP:0002725)1.55727188
166Reduced subcutaneous adipose tissue (HP:0003758)1.55724858
167Increased serum pyruvate (HP:0003542)1.55358805
168Abnormality of glycolysis (HP:0004366)1.55358805
169Neoplasm of the pancreas (HP:0002894)1.54980954
170Asymmetric septal hypertrophy (HP:0001670)1.54497581
171Abnormality of iron homeostasis (HP:0011031)1.54211182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.82581681
2VRK23.78173545
3NME23.54956563
4TESK12.90449019
5EIF2AK12.89527566
6EPHA22.73361296
7TESK22.69118810
8TRIB32.68206967
9WEE12.57602771
10PIM22.32264345
11RPS6KA42.19717128
12ERN12.12123791
13MAP3K121.99561514
14NEK11.95068575
15PKN21.76843716
16SMG11.75069289
17NEK21.74174199
18KDR1.69320633
19TLK11.56727509
20BCKDK1.55709425
21PAK41.49505897
22TTN1.47440740
23TBK11.46877972
24BLK1.45394053
25MAP3K111.42999931
26LRRK21.41371506
27BRSK21.39113425
28DYRK31.35553937
29MAP3K81.35402627
30RPS6KB21.34097538
31STK161.33920546
32LIMK11.33549649
33MAP3K31.30993372
34EIF2AK31.29637728
35CDK81.28476632
36MAP3K101.27847591
37PDK31.27018516
38PDK41.27018516
39NEK91.25819844
40ACVR1B1.25193184
41SCYL21.21487980
42MAP2K31.13606932
43VRK11.10842239
44PBK1.10721797
45CDC71.08958231
46MAPKAPK31.08788398
47STK101.08676399
48MST1R1.03372842
49TAOK21.02024884
50TYK21.01827174
51ZAP701.01478044
52AURKB1.01418706
53PDK21.01337004
54MAP4K11.00843267
55CSNK1G30.99424422
56TTK0.98499716
57DAPK10.96673775
58AURKA0.96113865
59PLK10.95693652
60ILK0.95486019
61MYLK0.93965761
62SRPK10.88755482
63ABL20.87409369
64TGFBR10.86260679
65PLK40.85782351
66PIM10.83059764
67EPHB20.82326698
68BRAF0.82257206
69ZAK0.80150957
70NME10.79988681
71PRKCI0.78515151
72EEF2K0.76923389
73TSSK60.76665160
74PAK10.76058002
75BRSK10.75647127
76ARAF0.74395117
77AKT20.72461748
78CDK40.72162926
79MST40.71745967
80PTK60.69180390
81CSNK1A1L0.69056152
82CDK70.68181708
83CCNB10.67937657
84FLT30.67486080
85MAP2K70.66841620
86MARK30.66588076
87ICK0.66368276
88DYRK1B0.65470878
89PIK3CG0.64486780
90PASK0.64245202
91CDK140.64001352
92PRKD30.62758603
93DAPK30.62178093
94STK40.61992452
95CDK11A0.61483999
96MAP3K50.59989423
97LMTK20.59904671
98KIT0.59488200
99FGFR40.57802557
100BMX0.57473862
101CDK60.57055447
102CDK190.56121137
103IRAK30.55933547
104CDK150.55611523
105MOS0.55308711
106CAMK2G0.54800875
107CHEK10.54760852
108CDK180.54045753
109JAK30.54013407
110STK38L0.53678105
111CSNK1G10.52960706
112IKBKB0.52543044
113ERBB40.52352777
114ATR0.51637363
115CLK10.51593700
116MAP2K20.51141631
117PTK20.50515186
118PLK30.50355067
119MAPKAPK50.49487196
120CSNK1G20.48669341
121PHKG20.46909952
122PHKG10.46909952
123DYRK20.46909037
124BTK0.46004642
125CDK90.45737537
126TGFBR20.44020789
127LATS20.43689390
128TAF10.43262264
129PAK20.43108392
130RPS6KA50.41468205
131CSNK2A10.41318749
132STK30.39743656
133CSNK2A20.33475395
134CHEK20.32933366
135MAPKAPK20.32888236
136MAPK110.32351174
137MUSK0.30918324
138CAMK2D0.24561919

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030504.12297127
2Ribosome_Homo sapiens_hsa030103.31859764
3DNA replication_Homo sapiens_hsa030303.18767328
4RNA polymerase_Homo sapiens_hsa030202.37760743
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36920493
6Mismatch repair_Homo sapiens_hsa034302.25456291
7RNA transport_Homo sapiens_hsa030132.13602164
8Pyrimidine metabolism_Homo sapiens_hsa002402.02591461
9Alzheimers disease_Homo sapiens_hsa050102.00536984
10One carbon pool by folate_Homo sapiens_hsa006702.00461829
11Spliceosome_Homo sapiens_hsa030401.97336307
12Pentose phosphate pathway_Homo sapiens_hsa000301.95596970
13Base excision repair_Homo sapiens_hsa034101.93056944
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88335636
15Fatty acid elongation_Homo sapiens_hsa000621.83962466
16Nucleotide excision repair_Homo sapiens_hsa034201.78458531
17p53 signaling pathway_Homo sapiens_hsa041151.54121024
18Cell cycle_Homo sapiens_hsa041101.53674335
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49253510
20Carbon metabolism_Homo sapiens_hsa012001.46284453
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45501813
22Legionellosis_Homo sapiens_hsa051341.44835694
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42458950
24Sulfur metabolism_Homo sapiens_hsa009201.42305648
25Biosynthesis of amino acids_Homo sapiens_hsa012301.40131715
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36864737
27Sulfur relay system_Homo sapiens_hsa041221.34159699
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.30841862
29Folate biosynthesis_Homo sapiens_hsa007901.28887037
30Selenocompound metabolism_Homo sapiens_hsa004501.28042243
31Vibrio cholerae infection_Homo sapiens_hsa051101.27190797
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27154533
33Cardiac muscle contraction_Homo sapiens_hsa042601.24352926
34Homologous recombination_Homo sapiens_hsa034401.23962685
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23403085
36Antigen processing and presentation_Homo sapiens_hsa046121.21419971
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15100946
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.13641005
39* Epstein-Barr virus infection_Homo sapiens_hsa051691.09485543
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.08312890
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07285580
42Systemic lupus erythematosus_Homo sapiens_hsa053221.07094643
43Glutathione metabolism_Homo sapiens_hsa004801.06407035
44Lysosome_Homo sapiens_hsa041421.00131777
45Fructose and mannose metabolism_Homo sapiens_hsa000510.99267815
46Shigellosis_Homo sapiens_hsa051310.96747971
47Apoptosis_Homo sapiens_hsa042100.94037706
48Viral carcinogenesis_Homo sapiens_hsa052030.92738059
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89032043
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88366018
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.87913902
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86936935
53Leishmaniasis_Homo sapiens_hsa051400.86506278
54Galactose metabolism_Homo sapiens_hsa000520.84983643
55Arginine and proline metabolism_Homo sapiens_hsa003300.83839278
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81686404
57Other glycan degradation_Homo sapiens_hsa005110.81004849
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78316784
59Purine metabolism_Homo sapiens_hsa002300.77934538
60Herpes simplex infection_Homo sapiens_hsa051680.75159173
61Collecting duct acid secretion_Homo sapiens_hsa049660.74545400
62Vitamin B6 metabolism_Homo sapiens_hsa007500.74089379
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73913188
64Steroid biosynthesis_Homo sapiens_hsa001000.71818078
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71380180
66Basal transcription factors_Homo sapiens_hsa030220.70272587
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69334294
68Bladder cancer_Homo sapiens_hsa052190.68153457
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67901623
70Non-homologous end-joining_Homo sapiens_hsa034500.66086528
71Staphylococcus aureus infection_Homo sapiens_hsa051500.64112302
72RNA degradation_Homo sapiens_hsa030180.62871527
73Small cell lung cancer_Homo sapiens_hsa052220.62413813
74Pyruvate metabolism_Homo sapiens_hsa006200.61848739
75Caffeine metabolism_Homo sapiens_hsa002320.61585883
76Phenylalanine metabolism_Homo sapiens_hsa003600.60392579
77Measles_Homo sapiens_hsa051620.57973060
78Propanoate metabolism_Homo sapiens_hsa006400.57613784
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.57026799
80HIF-1 signaling pathway_Homo sapiens_hsa040660.55974633
81HTLV-I infection_Homo sapiens_hsa051660.55325565
82Pertussis_Homo sapiens_hsa051330.54459913
83Phagosome_Homo sapiens_hsa041450.54204500
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53902800
85Peroxisome_Homo sapiens_hsa041460.53405618
86Malaria_Homo sapiens_hsa051440.53190516
87Fatty acid degradation_Homo sapiens_hsa000710.50603783
88Protein export_Homo sapiens_hsa030600.50424189
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49631064
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47651622
91Fat digestion and absorption_Homo sapiens_hsa049750.47620622
92Fatty acid metabolism_Homo sapiens_hsa012120.47196869
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47128808
94Parkinsons disease_Homo sapiens_hsa050120.46513691
95Huntingtons disease_Homo sapiens_hsa050160.45802321
96Tuberculosis_Homo sapiens_hsa051520.45668909
97mRNA surveillance pathway_Homo sapiens_hsa030150.45330553
98Influenza A_Homo sapiens_hsa051640.45298616
99Viral myocarditis_Homo sapiens_hsa054160.44830692
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44701183
101Synaptic vesicle cycle_Homo sapiens_hsa047210.44208195
102Complement and coagulation cascades_Homo sapiens_hsa046100.43613333
103Hepatitis B_Homo sapiens_hsa051610.43437944
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41403815
105Salmonella infection_Homo sapiens_hsa051320.41077379
106N-Glycan biosynthesis_Homo sapiens_hsa005100.40639888
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40528916
108Tyrosine metabolism_Homo sapiens_hsa003500.39768868
109Oxidative phosphorylation_Homo sapiens_hsa001900.38843743
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.38838962
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38722172
112Chronic myeloid leukemia_Homo sapiens_hsa052200.37595945
113Toxoplasmosis_Homo sapiens_hsa051450.36608075
114Thyroid cancer_Homo sapiens_hsa052160.36571205
115Metabolic pathways_Homo sapiens_hsa011000.33779186
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.33733568
117Arginine biosynthesis_Homo sapiens_hsa002200.33348875
118Fanconi anemia pathway_Homo sapiens_hsa034600.32311134
119Osteoclast differentiation_Homo sapiens_hsa043800.31847123
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29691642
121Alcoholism_Homo sapiens_hsa050340.27075132
122Oocyte meiosis_Homo sapiens_hsa041140.23972299
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19256198
124Prion diseases_Homo sapiens_hsa050200.18391718
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16282114
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09210642
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07989909
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07909347
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.07832481
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05486959

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