Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.93712735 |
2 | protein maturation by protein folding (GO:0022417) | 4.68130165 |
3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.28079147 |
4 | ATP synthesis coupled proton transport (GO:0015986) | 4.28079147 |
5 | regulation of mitochondrial translation (GO:0070129) | 4.26376271 |
6 | chaperone-mediated protein transport (GO:0072321) | 4.25876977 |
7 | formation of translation preinitiation complex (GO:0001731) | 4.23908541 |
8 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.19236086 |
9 | protein targeting to mitochondrion (GO:0006626) | 3.97827959 |
10 | respiratory electron transport chain (GO:0022904) | 3.97211313 |
11 | electron transport chain (GO:0022900) | 3.85275603 |
12 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.83888281 |
13 | maturation of SSU-rRNA (GO:0030490) | 3.78954865 |
14 | ribosomal small subunit assembly (GO:0000028) | 3.75257123 |
15 | viral transcription (GO:0019083) | 3.72502946 |
16 | establishment of protein localization to mitochondrion (GO:0072655) | 3.70011162 |
17 | COPI coating of Golgi vesicle (GO:0048205) | 3.66923567 |
18 | Golgi transport vesicle coating (GO:0048200) | 3.66923567 |
19 | translational termination (GO:0006415) | 3.66869411 |
20 | DNA deamination (GO:0045006) | 3.64600753 |
21 | establishment of integrated proviral latency (GO:0075713) | 3.59272180 |
22 | establishment of viral latency (GO:0019043) | 3.55632596 |
23 | protein localization to mitochondrion (GO:0070585) | 3.53727309 |
24 | termination of RNA polymerase III transcription (GO:0006386) | 3.52890236 |
25 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.52890236 |
26 | ribosomal large subunit biogenesis (GO:0042273) | 3.50511709 |
27 | proteasome assembly (GO:0043248) | 3.49908406 |
28 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.49742492 |
29 | purine nucleobase biosynthetic process (GO:0009113) | 3.48948960 |
30 | translational elongation (GO:0006414) | 3.47785768 |
31 | translational initiation (GO:0006413) | 3.47761367 |
32 | oxidative phosphorylation (GO:0006119) | 3.47090783 |
33 | * negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.44719732 |
34 | nucleobase biosynthetic process (GO:0046112) | 3.43643061 |
35 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.42414498 |
36 | nuclear envelope reassembly (GO:0031468) | 3.40918840 |
37 | mitotic nuclear envelope reassembly (GO:0007084) | 3.40918840 |
38 | GDP-mannose metabolic process (GO:0019673) | 3.34195536 |
39 | ribosome assembly (GO:0042255) | 3.33034372 |
40 | cellular component biogenesis (GO:0044085) | 3.30749213 |
41 | NADH metabolic process (GO:0006734) | 3.30018750 |
42 | * positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.29647704 |
43 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.28502012 |
44 | * antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.27400912 |
45 | * regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.26515582 |
46 | folic acid metabolic process (GO:0046655) | 3.25087462 |
47 | proline biosynthetic process (GO:0006561) | 3.23289207 |
48 | * anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.22297340 |
49 | * antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.21939891 |
50 | metallo-sulfur cluster assembly (GO:0031163) | 3.21270853 |
51 | iron-sulfur cluster assembly (GO:0016226) | 3.21270853 |
52 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.21269474 |
53 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.19943892 |
54 | UTP biosynthetic process (GO:0006228) | 3.19326963 |
55 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.19294297 |
56 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.15153161 |
57 | GTP biosynthetic process (GO:0006183) | 3.14928578 |
58 | * negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.14386843 |
59 | * negative regulation of ligase activity (GO:0051352) | 3.14386843 |
60 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.14169934 |
61 | protein targeting to ER (GO:0045047) | 3.09167024 |
62 | * DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.09088753 |
63 | tricarboxylic acid cycle (GO:0006099) | 3.08996720 |
64 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.08213594 |
65 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.08213594 |
66 | ribosomal small subunit biogenesis (GO:0042274) | 3.08066213 |
67 | regulation of translational fidelity (GO:0006450) | 3.07626315 |
68 | pseudouridine synthesis (GO:0001522) | 3.06612261 |
69 | cotranslational protein targeting to membrane (GO:0006613) | 3.05877949 |
70 | maturation of 5.8S rRNA (GO:0000460) | 3.03707242 |
71 | * intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.02912580 |
72 | * signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.02912580 |
73 | * signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.00659722 |
74 | * signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.00659722 |
75 | * signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.00659722 |
76 | * regulation of cellular amino acid metabolic process (GO:0006521) | 3.00126996 |
77 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.98439549 |
78 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.97974927 |
79 | * signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.97662136 |
80 | * signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.97662136 |
81 | viral life cycle (GO:0019058) | 2.97216600 |
82 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.96985054 |
83 | inner mitochondrial membrane organization (GO:0007007) | 2.96548169 |
84 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 2.95573787 |
85 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.94637687 |
86 | * positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.94157566 |
87 | protein localization to endoplasmic reticulum (GO:0070972) | 2.93708704 |
88 | DNA strand elongation (GO:0022616) | 2.93291216 |
89 | IMP biosynthetic process (GO:0006188) | 2.92321542 |
90 | * signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.92220069 |
91 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.91773936 |
92 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.90409027 |
93 | cellular protein complex disassembly (GO:0043624) | 2.87286019 |
94 | translation (GO:0006412) | 2.82931662 |
95 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.82504655 |
96 | * positive regulation of ligase activity (GO:0051351) | 2.79776255 |
97 | pentose-phosphate shunt (GO:0006098) | 2.78826152 |
98 | DNA replication initiation (GO:0006270) | 2.78785532 |
99 | mitotic nuclear envelope disassembly (GO:0007077) | 2.75725537 |
100 | protein localization to kinetochore (GO:0034501) | 2.74417625 |
101 | ribosome biogenesis (GO:0042254) | 2.72990252 |
102 | folic acid transport (GO:0015884) | 2.72298137 |
103 | IMP metabolic process (GO:0046040) | 2.68908332 |
104 | regulation of protein heterodimerization activity (GO:0043497) | 2.68727635 |
105 | regulation of translational termination (GO:0006449) | 2.68124228 |
106 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.66039599 |
107 | * positive regulation of cell cycle arrest (GO:0071158) | 2.64102602 |
108 | * regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.61618740 |
109 | DNA replication checkpoint (GO:0000076) | 2.59445475 |
110 | * antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.59100918 |
111 | nucleoside salvage (GO:0043174) | 2.57057384 |
112 | membrane disassembly (GO:0030397) | 2.56719360 |
113 | nuclear envelope disassembly (GO:0051081) | 2.56719360 |
114 | protein complex disassembly (GO:0043241) | 2.56351253 |
115 | telomere maintenance via recombination (GO:0000722) | 2.55239771 |
116 | natural killer cell mediated immunity (GO:0002228) | 2.54213170 |
117 | natural killer cell mediated cytotoxicity (GO:0042267) | 2.54213170 |
118 | protein localization to chromosome, centromeric region (GO:0071459) | 2.53930917 |
119 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.53179679 |
120 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.53179679 |
121 | spliceosomal snRNP assembly (GO:0000387) | 2.52739382 |
122 | mitotic metaphase plate congression (GO:0007080) | 2.51992441 |
123 | * cell cycle G1/S phase transition (GO:0044843) | 2.51777560 |
124 | * G1/S transition of mitotic cell cycle (GO:0000082) | 2.51777560 |
125 | * regulation of ligase activity (GO:0051340) | 2.50978335 |
126 | NADPH regeneration (GO:0006740) | 2.48640912 |
127 | rRNA processing (GO:0006364) | 2.48189882 |
128 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.47623841 |
129 | purine nucleotide salvage (GO:0032261) | 2.45875902 |
130 | macromolecular complex disassembly (GO:0032984) | 2.43654040 |
131 | DNA unwinding involved in DNA replication (GO:0006268) | 2.43619320 |
132 | T cell apoptotic process (GO:0070231) | 2.43249371 |
133 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 2.42429403 |
134 | AMP metabolic process (GO:0046033) | 2.42423856 |
135 | rRNA metabolic process (GO:0016072) | 2.40236977 |
136 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.39296491 |
137 | protein deneddylation (GO:0000338) | 2.35067027 |
138 | chaperone-mediated protein complex assembly (GO:0051131) | 2.33627309 |
139 | mitotic recombination (GO:0006312) | 2.32784982 |
140 | interferon-gamma secretion (GO:0072643) | 2.32132508 |
141 | glycine metabolic process (GO:0006544) | 2.31835698 |
142 | cullin deneddylation (GO:0010388) | 2.31472459 |
143 | galactose catabolic process (GO:0019388) | 2.27951559 |
144 | * DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.27302604 |
145 | histone-serine phosphorylation (GO:0035404) | 2.27278365 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.65800747 |
2 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.92796942 |
3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.47906197 |
4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.58673535 |
5 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.52673789 |
6 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.48480618 |
7 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.47974124 |
8 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.45015735 |
9 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.44066394 |
10 | * CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.38574526 |
11 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.36322902 |
12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.36297820 |
13 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.25487403 |
14 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.16041271 |
15 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.15053976 |
16 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.05845955 |
17 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.03334429 |
18 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.02689803 |
19 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.95592683 |
20 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.94926037 |
21 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.89821648 |
22 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.89245451 |
23 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.85162607 |
24 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.83973443 |
25 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.78984786 |
26 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.69537372 |
27 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.68768277 |
28 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.58947508 |
29 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.57013295 |
30 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.56158251 |
31 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.54885421 |
32 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.53844094 |
33 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.53454512 |
34 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.52400275 |
35 | MYC_22102868_ChIP-Seq_BL_Human | 1.48539081 |
36 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.47476238 |
37 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.47442874 |
38 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.46769130 |
39 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.46417788 |
40 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.41318569 |
41 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.40690726 |
42 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.40265081 |
43 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.40116297 |
44 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.38699664 |
45 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.38582832 |
46 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.36708011 |
47 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.35525513 |
48 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.34936078 |
49 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.34829018 |
50 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.34550004 |
51 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.33566164 |
52 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.32984513 |
53 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.32961662 |
54 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.31762830 |
55 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.31455992 |
56 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.30105824 |
57 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.29925742 |
58 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.29609857 |
59 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.28337445 |
60 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.28176668 |
61 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.26752967 |
62 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.26114369 |
63 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25835931 |
64 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.25150230 |
65 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.25033228 |
66 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.24233797 |
67 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.24041368 |
68 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.23991846 |
69 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.23772584 |
70 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.23612383 |
71 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.23089710 |
72 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.22650089 |
73 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.22284353 |
74 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.21611619 |
75 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.21603393 |
76 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.21105394 |
77 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.20565822 |
78 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.20307688 |
79 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.18300542 |
80 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.16306239 |
81 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.16067631 |
82 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.16016517 |
83 | ATF3_27146783_Chip-Seq_COLON_Human | 1.15389885 |
84 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.15326496 |
85 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.14440186 |
86 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.13025304 |
87 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.12612818 |
88 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.12368469 |
89 | * TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.11359431 |
90 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.10825751 |
91 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.10794049 |
92 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.10211029 |
93 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.09906701 |
94 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.09371798 |
95 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.09107618 |
96 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.08334805 |
97 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.07355205 |
98 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.06934487 |
99 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.06707149 |
100 | * ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.06574837 |
101 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.06347325 |
102 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.05485104 |
103 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.05435152 |
104 | * CIITA_25753668_ChIP-Seq_RAJI_Human | 1.03722622 |
105 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.02352031 |
106 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.99766258 |
107 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.99692837 |
108 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.99673777 |
109 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.99636011 |
110 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.98762306 |
111 | * BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.97313585 |
112 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.96309474 |
113 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.96215919 |
114 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.95909019 |
115 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.95732987 |
116 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.93720201 |
117 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.93618620 |
118 | * TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.93044711 |
119 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.92558020 |
120 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.88774374 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 3.60950113 |
2 | MP0004957_abnormal_blastocyst_morpholog | 2.80708467 |
3 | MP0009379_abnormal_foot_pigmentation | 2.72193413 |
4 | MP0009840_abnormal_foam_cell | 2.72060856 |
5 | MP0006036_abnormal_mitochondrial_physio | 2.66445522 |
6 | MP0010352_gastrointestinal_tract_polyps | 2.49470160 |
7 | MP0003705_abnormal_hypodermis_morpholog | 2.43437737 |
8 | MP0006035_abnormal_mitochondrial_morpho | 2.40652910 |
9 | MP0004233_abnormal_muscle_weight | 2.40019067 |
10 | MP0003806_abnormal_nucleotide_metabolis | 2.37413541 |
11 | MP0003111_abnormal_nucleus_morphology | 2.33520053 |
12 | MP0002877_abnormal_melanocyte_morpholog | 2.29354437 |
13 | MP0003077_abnormal_cell_cycle | 2.11530080 |
14 | MP0004858_abnormal_nervous_system | 1.95601110 |
15 | MP0008438_abnormal_cutaneous_collagen | 1.93122569 |
16 | MP0005058_abnormal_lysosome_morphology | 1.91173261 |
17 | MP0008260_abnormal_autophagy | 1.88880067 |
18 | MP0000749_muscle_degeneration | 1.87637689 |
19 | MP0003436_decreased_susceptibility_to | 1.86706014 |
20 | MP0010094_abnormal_chromosome_stability | 1.81293959 |
21 | MP0003186_abnormal_redox_activity | 1.81279881 |
22 | MP0001727_abnormal_embryo_implantation | 1.80090216 |
23 | MP0005623_abnormal_meninges_morphology | 1.78958107 |
24 | MP0010307_abnormal_tumor_latency | 1.72671978 |
25 | MP0008007_abnormal_cellular_replicative | 1.72457569 |
26 | MP0003566_abnormal_cell_adhesion | 1.65684266 |
27 | MP0009333_abnormal_splenocyte_physiolog | 1.65366603 |
28 | MP0004185_abnormal_adipocyte_glucose | 1.64962862 |
29 | MP0000858_altered_metastatic_potential | 1.62315567 |
30 | MP0003941_abnormal_skin_development | 1.57758643 |
31 | MP0005023_abnormal_wound_healing | 1.56243866 |
32 | MP0005330_cardiomyopathy | 1.55437888 |
33 | MP0008932_abnormal_embryonic_tissue | 1.51265127 |
34 | MP0001661_extended_life_span | 1.47172550 |
35 | MP0001730_embryonic_growth_arrest | 1.44063975 |
36 | MP0000750_abnormal_muscle_regeneration | 1.43724702 |
37 | MP0006054_spinal_hemorrhage | 1.42648439 |
38 | MP0001853_heart_inflammation | 1.39600884 |
39 | MP0000678_abnormal_parathyroid_gland | 1.38559274 |
40 | MP0000490_abnormal_crypts_of | 1.35852198 |
41 | MP0000751_myopathy | 1.34429462 |
42 | MP0003191_abnormal_cellular_cholesterol | 1.34187444 |
43 | MP0001835_abnormal_antigen_presentation | 1.33793586 |
44 | MP0003315_abnormal_perineum_morphology | 1.31634138 |
45 | MP0000350_abnormal_cell_proliferation | 1.29506073 |
46 | MP0005275_abnormal_skin_tensile | 1.28174541 |
47 | MP0000537_abnormal_urethra_morphology | 1.27157008 |
48 | MP0000747_muscle_weakness | 1.25377900 |
49 | MP0000358_abnormal_cell_content/ | 1.21487882 |
50 | MP0009785_altered_susceptibility_to | 1.20429720 |
51 | MP0003123_paternal_imprinting | 1.18735853 |
52 | MP0000759_abnormal_skeletal_muscle | 1.17857128 |
53 | MP0004947_skin_inflammation | 1.17297424 |
54 | MP0003303_peritoneal_inflammation | 1.16666500 |
55 | MP0002019_abnormal_tumor_incidence | 1.13087256 |
56 | MP0000003_abnormal_adipose_tissue | 1.12346382 |
57 | MP0005397_hematopoietic_system_phenotyp | 1.11701676 |
58 | MP0001545_abnormal_hematopoietic_system | 1.11701676 |
59 | MP0000685_abnormal_immune_system | 1.10710981 |
60 | MP0003221_abnormal_cardiomyocyte_apopto | 1.10094138 |
61 | MP0005257_abnormal_intraocular_pressure | 1.09229989 |
62 | MP0001542_abnormal_bone_strength | 1.08949416 |
63 | MP0001881_abnormal_mammary_gland | 1.08915641 |
64 | MP0003448_altered_tumor_morphology | 1.08907146 |
65 | MP0003011_delayed_dark_adaptation | 1.07480816 |
66 | MP0000343_altered_response_to | 1.05849855 |
67 | MP0001764_abnormal_homeostasis | 1.05453019 |
68 | MP0009697_abnormal_copulation | 1.03218338 |
69 | MP0002080_prenatal_lethality | 1.03052881 |
70 | MP0001533_abnormal_skeleton_physiology | 1.02561495 |
71 | MP0006082_CNS_inflammation | 1.01772063 |
72 | MP0002269_muscular_atrophy | 1.01430436 |
73 | MP0003950_abnormal_plasma_membrane | 1.00123027 |
74 | MP0002452_abnormal_antigen_presenting | 0.98565603 |
75 | MP0001697_abnormal_embryo_size | 0.98243489 |
76 | MP0003718_maternal_effect | 0.97896206 |
77 | MP0003786_premature_aging | 0.97538224 |
78 | MP0005025_abnormal_response_to | 0.96829149 |
79 | MP0002419_abnormal_innate_immunity | 0.96571420 |
80 | MP0004808_abnormal_hematopoietic_stem | 0.96284482 |
81 | MP0004272_abnormal_basement_membrane | 0.95582146 |
82 | MP0000598_abnormal_liver_morphology | 0.95101580 |
83 | MP0002396_abnormal_hematopoietic_system | 0.94537916 |
84 | MP0003385_abnormal_body_wall | 0.94487014 |
85 | MP0001243_abnormal_dermal_layer | 0.94257592 |
86 | MP0005380_embryogenesis_phenotype | 0.94063016 |
87 | MP0001672_abnormal_embryogenesis/_devel | 0.94063016 |
88 | MP0010234_abnormal_vibrissa_follicle | 0.94045182 |
89 | MP0000313_abnormal_cell_death | 0.93636039 |
90 | MP0003984_embryonic_growth_retardation | 0.93474172 |
91 | MP0002405_respiratory_system_inflammati | 0.93390711 |
92 | MP0002088_abnormal_embryonic_growth/wei | 0.92722926 |
93 | MP0005000_abnormal_immune_tolerance | 0.92580387 |
94 | MP0008058_abnormal_DNA_repair | 0.92453452 |
95 | MP0009053_abnormal_anal_canal | 0.92055520 |
96 | MP0002722_abnormal_immune_system | 0.91643335 |
97 | MP0000689_abnormal_spleen_morphology | 0.91536855 |
98 | MP0000372_irregular_coat_pigmentation | 0.91133361 |
99 | MP0008789_abnormal_olfactory_epithelium | 0.90941118 |
100 | MP0005501_abnormal_skin_physiology | 0.90859508 |
101 | MP0005076_abnormal_cell_differentiation | 0.90759214 |
102 | MP0002234_abnormal_pharynx_morphology | 0.90203105 |
103 | MP0005319_abnormal_enzyme/_coenzyme | 0.90197865 |
104 | MP0008469_abnormal_protein_level | 0.89659705 |
105 | MP0001529_abnormal_vocalization | 0.89609284 |
106 | MP0003279_aneurysm | 0.88659947 |
107 | MP0002148_abnormal_hypersensitivity_rea | 0.87351687 |
108 | MP0005408_hypopigmentation | 0.86625202 |
109 | MP0003453_abnormal_keratinocyte_physiol | 0.86246292 |
110 | MP0000609_abnormal_liver_physiology | 0.86063014 |
111 | MP0002837_dystrophic_cardiac_calcinosis | 0.85825145 |
112 | MP0002163_abnormal_gland_morphology | 0.85523443 |
113 | MP0002796_impaired_skin_barrier | 0.85396953 |
114 | MP0001845_abnormal_inflammatory_respons | 0.85158865 |
115 | MP0002398_abnormal_bone_marrow | 0.85066661 |
116 | MP0005464_abnormal_platelet_physiology | 0.84318710 |
117 | MP0001800_abnormal_humoral_immune | 0.83181253 |
118 | MP0002429_abnormal_blood_cell | 0.83006943 |
119 | MP0002085_abnormal_embryonic_tissue | 0.82872945 |
120 | MP0010030_abnormal_orbit_morphology | 0.82676693 |
121 | MP0000733_abnormal_muscle_development | 0.81792872 |
122 | MP0005083_abnormal_biliary_tract | 0.81550454 |
123 | MP0002723_abnormal_immune_serum | 0.81270280 |
124 | MP0002139_abnormal_hepatobiliary_system | 0.80023109 |
125 | MP0001819_abnormal_immune_cell | 0.79264451 |
126 | MP0002086_abnormal_extraembryonic_tissu | 0.78790189 |
127 | MP0000049_abnormal_middle_ear | 0.78762466 |
128 | MP0002420_abnormal_adaptive_immunity | 0.78200597 |
129 | MP0005384_cellular_phenotype | 0.77668635 |
130 | MP0009672_abnormal_birth_weight | 0.77472616 |
131 | MP0005670_abnormal_white_adipose | 0.77320474 |
132 | MP0004197_abnormal_fetal_growth/weight/ | 0.77264184 |
133 | MP0002060_abnormal_skin_morphology | 0.77169700 |
134 | MP0001849_ear_inflammation | 0.75235530 |
135 | MP0001915_intracranial_hemorrhage | 0.75037990 |
136 | MP0001958_emphysema | 0.74816632 |
137 | MP0005451_abnormal_body_composition | 0.74701416 |
138 | MP0010155_abnormal_intestine_physiology | 0.74674623 |
139 | MP0005360_urolithiasis | 0.74575338 |
140 | MP0004087_abnormal_muscle_fiber | 0.74259368 |
141 | MP0005375_adipose_tissue_phenotype | 0.74171839 |
142 | MP0002210_abnormal_sex_determination | 0.72811469 |
143 | MP0005165_increased_susceptibility_to | 0.72528251 |
144 | MP0001346_abnormal_lacrimal_gland | 0.72519181 |
145 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.71696764 |
146 | MP0002970_abnormal_white_adipose | 0.71049307 |
147 | MP0002160_abnormal_reproductive_system | 0.71011861 |
148 | MP0005332_abnormal_amino_acid | 0.70492753 |
149 | MP0000762_abnormal_tongue_morphology | 0.70458181 |
150 | MP0005666_abnormal_adipose_tissue | 0.68015456 |
151 | MP0002177_abnormal_outer_ear | 0.67401014 |
152 | MP0000013_abnormal_adipose_tissue | 0.66611536 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.08081426 |
2 | Acute necrotizing encephalopathy (HP:0006965) | 4.89791753 |
3 | Acute encephalopathy (HP:0006846) | 4.43835274 |
4 | Mitochondrial inheritance (HP:0001427) | 4.19438069 |
5 | Hepatocellular necrosis (HP:0001404) | 3.99331392 |
6 | Increased CSF lactate (HP:0002490) | 3.93623408 |
7 | Progressive macrocephaly (HP:0004481) | 3.71686851 |
8 | Hepatic necrosis (HP:0002605) | 3.71014224 |
9 | Increased intramyocellular lipid droplets (HP:0012240) | 3.67975918 |
10 | Cerebral edema (HP:0002181) | 3.43032253 |
11 | Multiple enchondromatosis (HP:0005701) | 3.37805463 |
12 | Increased muscle lipid content (HP:0009058) | 3.37777609 |
13 | Exercise intolerance (HP:0003546) | 3.31966251 |
14 | Lactic acidosis (HP:0003128) | 3.28910763 |
15 | Abnormal gallbladder physiology (HP:0012438) | 3.19579210 |
16 | Cholecystitis (HP:0001082) | 3.19579210 |
17 | Increased serum lactate (HP:0002151) | 3.15194058 |
18 | Trismus (HP:0000211) | 3.14046710 |
19 | Microvesicular hepatic steatosis (HP:0001414) | 3.13806308 |
20 | Ragged-red muscle fibers (HP:0003200) | 3.09601035 |
21 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.02535813 |
22 | Premature rupture of membranes (HP:0001788) | 2.99826189 |
23 | Increased hepatocellular lipid droplets (HP:0006565) | 2.99128250 |
24 | Abnormality of the anterior horn cell (HP:0006802) | 2.97469353 |
25 | Degeneration of anterior horn cells (HP:0002398) | 2.97469353 |
26 | Reticulocytopenia (HP:0001896) | 2.92478374 |
27 | Respiratory failure (HP:0002878) | 2.89429553 |
28 | Renal Fanconi syndrome (HP:0001994) | 2.89366941 |
29 | Type I transferrin isoform profile (HP:0003642) | 2.86362311 |
30 | Lipid accumulation in hepatocytes (HP:0006561) | 2.84653066 |
31 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.78204202 |
32 | Protrusio acetabuli (HP:0003179) | 2.72872504 |
33 | Rhabdomyolysis (HP:0003201) | 2.62105968 |
34 | Nausea (HP:0002018) | 2.59058317 |
35 | Hypokinesia (HP:0002375) | 2.58729356 |
36 | Testicular atrophy (HP:0000029) | 2.58606057 |
37 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.57692045 |
38 | Vacuolated lymphocytes (HP:0001922) | 2.57433542 |
39 | Breast hypoplasia (HP:0003187) | 2.54046708 |
40 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.51092081 |
41 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.51092081 |
42 | Abnormal protein glycosylation (HP:0012346) | 2.51092081 |
43 | Abnormal glycosylation (HP:0012345) | 2.51092081 |
44 | Poor head control (HP:0002421) | 2.50259785 |
45 | Ulnar deviation of the wrist (HP:0003049) | 2.49862221 |
46 | Vertebral compression fractures (HP:0002953) | 2.49515799 |
47 | Rough bone trabeculation (HP:0100670) | 2.46993475 |
48 | Abnormal number of erythroid precursors (HP:0012131) | 2.46032736 |
49 | Oral leukoplakia (HP:0002745) | 2.44043263 |
50 | 3-Methylglutaconic aciduria (HP:0003535) | 2.41550449 |
51 | Aplastic anemia (HP:0001915) | 2.35814289 |
52 | Cerebral hypomyelination (HP:0006808) | 2.35288330 |
53 | Emotional lability (HP:0000712) | 2.32854417 |
54 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.31057365 |
55 | Cervical subluxation (HP:0003308) | 2.30866437 |
56 | Personality changes (HP:0000751) | 2.26132621 |
57 | Microretrognathia (HP:0000308) | 2.26101304 |
58 | Carpal bone hypoplasia (HP:0001498) | 2.23202111 |
59 | Calcaneovalgus deformity (HP:0001848) | 2.22867167 |
60 | Macrocytic anemia (HP:0001972) | 2.22260737 |
61 | Abnormality of the calcaneus (HP:0008364) | 2.21679598 |
62 | Redundant skin (HP:0001582) | 2.20033766 |
63 | Difficulty climbing stairs (HP:0003551) | 2.13470802 |
64 | Pallor (HP:0000980) | 2.12272196 |
65 | Upper limb muscle weakness (HP:0003484) | 2.11094756 |
66 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.08722369 |
67 | Eczematoid dermatitis (HP:0000976) | 2.08555900 |
68 | Selective tooth agenesis (HP:0001592) | 2.08437567 |
69 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.08220873 |
70 | Myopathic facies (HP:0002058) | 2.06648405 |
71 | Pancytopenia (HP:0001876) | 2.06499453 |
72 | Recurrent abscess formation (HP:0002722) | 2.05781242 |
73 | Deformed tarsal bones (HP:0008119) | 2.04771365 |
74 | Increased cerebral lipofuscin (HP:0011813) | 2.04707006 |
75 | Leukodystrophy (HP:0002415) | 2.03305235 |
76 | Lethargy (HP:0001254) | 2.03272912 |
77 | Abnormal cartilage morphology (HP:0002763) | 2.02148043 |
78 | Nemaline bodies (HP:0003798) | 2.00956247 |
79 | Muscle fiber inclusion bodies (HP:0100299) | 1.99922861 |
80 | Thrombocytosis (HP:0001894) | 1.97604702 |
81 | Petechiae (HP:0000967) | 1.96808032 |
82 | Respiratory difficulties (HP:0002880) | 1.96724583 |
83 | Opisthotonus (HP:0002179) | 1.95546602 |
84 | Reduced antithrombin III activity (HP:0001976) | 1.95055562 |
85 | CNS demyelination (HP:0007305) | 1.94770243 |
86 | Abnormality of the tricuspid valve (HP:0001702) | 1.93099267 |
87 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.92536770 |
88 | Pustule (HP:0200039) | 1.92502819 |
89 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.92199478 |
90 | Cutaneous melanoma (HP:0012056) | 1.91507312 |
91 | Recurrent bacterial skin infections (HP:0005406) | 1.90980442 |
92 | Dicarboxylic aciduria (HP:0003215) | 1.90931466 |
93 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.90931466 |
94 | Abnormality of the umbilical cord (HP:0010881) | 1.89973465 |
95 | Generalized aminoaciduria (HP:0002909) | 1.89487353 |
96 | Distal lower limb amyotrophy (HP:0008944) | 1.89220633 |
97 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.88924936 |
98 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.88924936 |
99 | Osteolytic defects of the hand bones (HP:0009699) | 1.88543742 |
100 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.88543742 |
101 | Hyperthyroidism (HP:0000836) | 1.88529090 |
102 | Birth length less than 3rd percentile (HP:0003561) | 1.88507994 |
103 | Cholelithiasis (HP:0001081) | 1.88103475 |
104 | Abnormal trabecular bone morphology (HP:0100671) | 1.87338079 |
105 | Generalized amyotrophy (HP:0003700) | 1.86697605 |
106 | Secondary amenorrhea (HP:0000869) | 1.86595991 |
107 | Peritonitis (HP:0002586) | 1.86064226 |
108 | Broad distal phalanx of finger (HP:0009836) | 1.85390819 |
109 | Beaking of vertebral bodies (HP:0004568) | 1.85275288 |
110 | Premature ovarian failure (HP:0008209) | 1.83791899 |
111 | Distal arthrogryposis (HP:0005684) | 1.83470031 |
112 | Agnosia (HP:0010524) | 1.83288740 |
113 | Increased serum ferritin (HP:0003281) | 1.82997929 |
114 | Esophageal neoplasm (HP:0100751) | 1.82930738 |
115 | Neoplasm of head and neck (HP:0012288) | 1.82930738 |
116 | Abnormality of macrophages (HP:0004311) | 1.82000961 |
117 | Mucosal telangiectasiae (HP:0100579) | 1.81831817 |
118 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.81130524 |
119 | Abnormality of placental membranes (HP:0011409) | 1.80398723 |
120 | Amniotic constriction ring (HP:0009775) | 1.80398723 |
121 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.79160154 |
122 | Short nail (HP:0001799) | 1.78810800 |
123 | X-linked dominant inheritance (HP:0001423) | 1.77643589 |
124 | Single umbilical artery (HP:0001195) | 1.77622531 |
125 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.77622531 |
126 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.77622531 |
127 | Entropion (HP:0000621) | 1.77521580 |
128 | Progressive muscle weakness (HP:0003323) | 1.77043802 |
129 | Hypobetalipoproteinemia (HP:0003563) | 1.76127766 |
130 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.75596486 |
131 | Hypertensive crisis (HP:0100735) | 1.75447605 |
132 | Increased density of long bones (HP:0006392) | 1.75306099 |
133 | Optic disc pallor (HP:0000543) | 1.75079460 |
134 | Increased connective tissue (HP:0009025) | 1.73944556 |
135 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.73114160 |
136 | Sparse eyelashes (HP:0000653) | 1.72585183 |
137 | Hand muscle atrophy (HP:0009130) | 1.72409088 |
138 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.72220801 |
139 | Spastic diplegia (HP:0001264) | 1.72001928 |
140 | Distal lower limb muscle weakness (HP:0009053) | 1.71893794 |
141 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.71639884 |
142 | Truncus arteriosus (HP:0001660) | 1.71056070 |
143 | Fasciculations (HP:0002380) | 1.70954324 |
144 | Abnormal hemoglobin (HP:0011902) | 1.70911778 |
145 | Joint stiffness (HP:0001387) | 1.70909178 |
146 | Muscle fiber atrophy (HP:0100295) | 1.70111680 |
147 | Nonimmune hydrops fetalis (HP:0001790) | 1.70044143 |
148 | Abnormality of the Achilles tendon (HP:0005109) | 1.69451303 |
149 | Abnormality of reticulocytes (HP:0004312) | 1.69119633 |
150 | Dysostosis multiplex (HP:0000943) | 1.68942567 |
151 | Angiofibromas (HP:0010615) | 1.66243154 |
152 | Adenoma sebaceum (HP:0009720) | 1.66243154 |
153 | Xanthomatosis (HP:0000991) | 1.66192983 |
154 | Abnormality of subcutaneous fat tissue (HP:0001001) | 1.62478159 |
155 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.61594426 |
156 | Interstitial pulmonary disease (HP:0006530) | 1.61040398 |
157 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.60897027 |
158 | Abnormality of alanine metabolism (HP:0010916) | 1.60897027 |
159 | Hyperalaninemia (HP:0003348) | 1.60897027 |
160 | Abnormality of the motor neurons (HP:0002450) | 1.58385793 |
161 | Abnormal neuron morphology (HP:0012757) | 1.58385793 |
162 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.56570857 |
163 | Pelvic girdle muscle weakness (HP:0003749) | 1.56171057 |
164 | Achilles tendon contracture (HP:0001771) | 1.55915840 |
165 | Systemic lupus erythematosus (HP:0002725) | 1.55727188 |
166 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.55724858 |
167 | Increased serum pyruvate (HP:0003542) | 1.55358805 |
168 | Abnormality of glycolysis (HP:0004366) | 1.55358805 |
169 | Neoplasm of the pancreas (HP:0002894) | 1.54980954 |
170 | Asymmetric septal hypertrophy (HP:0001670) | 1.54497581 |
171 | Abnormality of iron homeostasis (HP:0011031) | 1.54211182 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BUB1 | 3.82581681 |
2 | VRK2 | 3.78173545 |
3 | NME2 | 3.54956563 |
4 | TESK1 | 2.90449019 |
5 | EIF2AK1 | 2.89527566 |
6 | EPHA2 | 2.73361296 |
7 | TESK2 | 2.69118810 |
8 | TRIB3 | 2.68206967 |
9 | WEE1 | 2.57602771 |
10 | PIM2 | 2.32264345 |
11 | RPS6KA4 | 2.19717128 |
12 | ERN1 | 2.12123791 |
13 | MAP3K12 | 1.99561514 |
14 | NEK1 | 1.95068575 |
15 | PKN2 | 1.76843716 |
16 | SMG1 | 1.75069289 |
17 | NEK2 | 1.74174199 |
18 | KDR | 1.69320633 |
19 | TLK1 | 1.56727509 |
20 | BCKDK | 1.55709425 |
21 | PAK4 | 1.49505897 |
22 | TTN | 1.47440740 |
23 | TBK1 | 1.46877972 |
24 | BLK | 1.45394053 |
25 | MAP3K11 | 1.42999931 |
26 | LRRK2 | 1.41371506 |
27 | BRSK2 | 1.39113425 |
28 | DYRK3 | 1.35553937 |
29 | MAP3K8 | 1.35402627 |
30 | RPS6KB2 | 1.34097538 |
31 | STK16 | 1.33920546 |
32 | LIMK1 | 1.33549649 |
33 | MAP3K3 | 1.30993372 |
34 | EIF2AK3 | 1.29637728 |
35 | CDK8 | 1.28476632 |
36 | MAP3K10 | 1.27847591 |
37 | PDK4 | 1.27018516 |
38 | PDK3 | 1.27018516 |
39 | NEK9 | 1.25819844 |
40 | ACVR1B | 1.25193184 |
41 | SCYL2 | 1.21487980 |
42 | MAP2K3 | 1.13606932 |
43 | VRK1 | 1.10842239 |
44 | PBK | 1.10721797 |
45 | CDC7 | 1.08958231 |
46 | MAPKAPK3 | 1.08788398 |
47 | STK10 | 1.08676399 |
48 | MST1R | 1.03372842 |
49 | TAOK2 | 1.02024884 |
50 | TYK2 | 1.01827174 |
51 | ZAP70 | 1.01478044 |
52 | AURKB | 1.01418706 |
53 | PDK2 | 1.01337004 |
54 | MAP4K1 | 1.00843267 |
55 | CSNK1G3 | 0.99424422 |
56 | TTK | 0.98499716 |
57 | DAPK1 | 0.96673775 |
58 | AURKA | 0.96113865 |
59 | PLK1 | 0.95693652 |
60 | ILK | 0.95486019 |
61 | MYLK | 0.93965761 |
62 | SRPK1 | 0.88755482 |
63 | ABL2 | 0.87409369 |
64 | TGFBR1 | 0.86260679 |
65 | PLK4 | 0.85782351 |
66 | PIM1 | 0.83059764 |
67 | EPHB2 | 0.82326698 |
68 | BRAF | 0.82257206 |
69 | ZAK | 0.80150957 |
70 | NME1 | 0.79988681 |
71 | PRKCI | 0.78515151 |
72 | EEF2K | 0.76923389 |
73 | TSSK6 | 0.76665160 |
74 | PAK1 | 0.76058002 |
75 | BRSK1 | 0.75647127 |
76 | ARAF | 0.74395117 |
77 | AKT2 | 0.72461748 |
78 | CDK4 | 0.72162926 |
79 | MST4 | 0.71745967 |
80 | PTK6 | 0.69180390 |
81 | CSNK1A1L | 0.69056152 |
82 | CDK7 | 0.68181708 |
83 | CCNB1 | 0.67937657 |
84 | FLT3 | 0.67486080 |
85 | MAP2K7 | 0.66841620 |
86 | MARK3 | 0.66588076 |
87 | ICK | 0.66368276 |
88 | DYRK1B | 0.65470878 |
89 | PIK3CG | 0.64486780 |
90 | PASK | 0.64245202 |
91 | CDK14 | 0.64001352 |
92 | PRKD3 | 0.62758603 |
93 | DAPK3 | 0.62178093 |
94 | STK4 | 0.61992452 |
95 | CDK11A | 0.61483999 |
96 | MAP3K5 | 0.59989423 |
97 | LMTK2 | 0.59904671 |
98 | KIT | 0.59488200 |
99 | FGFR4 | 0.57802557 |
100 | BMX | 0.57473862 |
101 | CDK6 | 0.57055447 |
102 | CDK19 | 0.56121137 |
103 | IRAK3 | 0.55933547 |
104 | CDK15 | 0.55611523 |
105 | MOS | 0.55308711 |
106 | CAMK2G | 0.54800875 |
107 | CHEK1 | 0.54760852 |
108 | CDK18 | 0.54045753 |
109 | JAK3 | 0.54013407 |
110 | STK38L | 0.53678105 |
111 | CSNK1G1 | 0.52960706 |
112 | IKBKB | 0.52543044 |
113 | ERBB4 | 0.52352777 |
114 | ATR | 0.51637363 |
115 | CLK1 | 0.51593700 |
116 | MAP2K2 | 0.51141631 |
117 | PTK2 | 0.50515186 |
118 | PLK3 | 0.50355067 |
119 | MAPKAPK5 | 0.49487196 |
120 | CSNK1G2 | 0.48669341 |
121 | PHKG2 | 0.46909952 |
122 | PHKG1 | 0.46909952 |
123 | DYRK2 | 0.46909037 |
124 | BTK | 0.46004642 |
125 | CDK9 | 0.45737537 |
126 | TGFBR2 | 0.44020789 |
127 | LATS2 | 0.43689390 |
128 | TAF1 | 0.43262264 |
129 | PAK2 | 0.43108392 |
130 | RPS6KA5 | 0.41468205 |
131 | CSNK2A1 | 0.41318749 |
132 | STK3 | 0.39743656 |
133 | CSNK2A2 | 0.33475395 |
134 | CHEK2 | 0.32933366 |
135 | MAPKAPK2 | 0.32888236 |
136 | MAPK11 | 0.32351174 |
137 | MUSK | 0.30918324 |
138 | CAMK2D | 0.24561919 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * Proteasome_Homo sapiens_hsa03050 | 4.12297127 |
2 | Ribosome_Homo sapiens_hsa03010 | 3.31859764 |
3 | DNA replication_Homo sapiens_hsa03030 | 3.18767328 |
4 | RNA polymerase_Homo sapiens_hsa03020 | 2.37760743 |
5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.36920493 |
6 | Mismatch repair_Homo sapiens_hsa03430 | 2.25456291 |
7 | RNA transport_Homo sapiens_hsa03013 | 2.13602164 |
8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.02591461 |
9 | Alzheimers disease_Homo sapiens_hsa05010 | 2.00536984 |
10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.00461829 |
11 | Spliceosome_Homo sapiens_hsa03040 | 1.97336307 |
12 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.95596970 |
13 | Base excision repair_Homo sapiens_hsa03410 | 1.93056944 |
14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.88335636 |
15 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.83962466 |
16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.78458531 |
17 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.54121024 |
18 | Cell cycle_Homo sapiens_hsa04110 | 1.53674335 |
19 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.49253510 |
20 | Carbon metabolism_Homo sapiens_hsa01200 | 1.46284453 |
21 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.45501813 |
22 | Legionellosis_Homo sapiens_hsa05134 | 1.44835694 |
23 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.42458950 |
24 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.42305648 |
25 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.40131715 |
26 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.36864737 |
27 | Sulfur relay system_Homo sapiens_hsa04122 | 1.34159699 |
28 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.30841862 |
29 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.28887037 |
30 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.28042243 |
31 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.27190797 |
32 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.27154533 |
33 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.24352926 |
34 | Homologous recombination_Homo sapiens_hsa03440 | 1.23962685 |
35 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.23403085 |
36 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.21419971 |
37 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.15100946 |
38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.13641005 |
39 | * Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.09485543 |
40 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.08312890 |
41 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.07285580 |
42 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.07094643 |
43 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.06407035 |
44 | Lysosome_Homo sapiens_hsa04142 | 1.00131777 |
45 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.99267815 |
46 | Shigellosis_Homo sapiens_hsa05131 | 0.96747971 |
47 | Apoptosis_Homo sapiens_hsa04210 | 0.94037706 |
48 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.92738059 |
49 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.89032043 |
50 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.88366018 |
51 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.87913902 |
52 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.86936935 |
53 | Leishmaniasis_Homo sapiens_hsa05140 | 0.86506278 |
54 | Galactose metabolism_Homo sapiens_hsa00052 | 0.84983643 |
55 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.83839278 |
56 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.81686404 |
57 | Other glycan degradation_Homo sapiens_hsa00511 | 0.81004849 |
58 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.78316784 |
59 | Purine metabolism_Homo sapiens_hsa00230 | 0.77934538 |
60 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.75159173 |
61 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.74545400 |
62 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.74089379 |
63 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.73913188 |
64 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.71818078 |
65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.71380180 |
66 | Basal transcription factors_Homo sapiens_hsa03022 | 0.70272587 |
67 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.69334294 |
68 | Bladder cancer_Homo sapiens_hsa05219 | 0.68153457 |
69 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.67901623 |
70 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.66086528 |
71 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.64112302 |
72 | RNA degradation_Homo sapiens_hsa03018 | 0.62871527 |
73 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.62413813 |
74 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.61848739 |
75 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.61585883 |
76 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.60392579 |
77 | Measles_Homo sapiens_hsa05162 | 0.57973060 |
78 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.57613784 |
79 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.57026799 |
80 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.55974633 |
81 | HTLV-I infection_Homo sapiens_hsa05166 | 0.55325565 |
82 | Pertussis_Homo sapiens_hsa05133 | 0.54459913 |
83 | Phagosome_Homo sapiens_hsa04145 | 0.54204500 |
84 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.53902800 |
85 | Peroxisome_Homo sapiens_hsa04146 | 0.53405618 |
86 | Malaria_Homo sapiens_hsa05144 | 0.53190516 |
87 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.50603783 |
88 | Protein export_Homo sapiens_hsa03060 | 0.50424189 |
89 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.49631064 |
90 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.47651622 |
91 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.47620622 |
92 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.47196869 |
93 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.47128808 |
94 | Parkinsons disease_Homo sapiens_hsa05012 | 0.46513691 |
95 | Huntingtons disease_Homo sapiens_hsa05016 | 0.45802321 |
96 | Tuberculosis_Homo sapiens_hsa05152 | 0.45668909 |
97 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.45330553 |
98 | Influenza A_Homo sapiens_hsa05164 | 0.45298616 |
99 | Viral myocarditis_Homo sapiens_hsa05416 | 0.44830692 |
100 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.44701183 |
101 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.44208195 |
102 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.43613333 |
103 | Hepatitis B_Homo sapiens_hsa05161 | 0.43437944 |
104 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.41403815 |
105 | Salmonella infection_Homo sapiens_hsa05132 | 0.41077379 |
106 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.40639888 |
107 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.40528916 |
108 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.39768868 |
109 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.38843743 |
110 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.38838962 |
111 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.38722172 |
112 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.37595945 |
113 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.36608075 |
114 | Thyroid cancer_Homo sapiens_hsa05216 | 0.36571205 |
115 | Metabolic pathways_Homo sapiens_hsa01100 | 0.33779186 |
116 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.33733568 |
117 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.33348875 |
118 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.32311134 |
119 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.31847123 |
120 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.29691642 |
121 | Alcoholism_Homo sapiens_hsa05034 | 0.27075132 |
122 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.23972299 |
123 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.19256198 |
124 | Prion diseases_Homo sapiens_hsa05020 | 0.18391718 |
125 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.16282114 |
126 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.09210642 |
127 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.07989909 |
128 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.07909347 |
129 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.07832481 |
130 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.05486959 |