PSMD8P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cysteine metabolic process (GO:0006534)6.00260716
2regulation of plasminogen activation (GO:0010755)5.66731321
3sulfur amino acid catabolic process (GO:0000098)5.45186464
4homocysteine metabolic process (GO:0050667)5.16146254
5detection of molecule of bacterial origin (GO:0032490)5.06112671
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.85612433
7tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.85612433
8purine nucleotide salvage (GO:0032261)4.75162341
9microtubule nucleation (GO:0007020)4.64246331
10positive regulation of gamma-delta T cell activation (GO:0046645)4.57080530
11platelet dense granule organization (GO:0060155)4.32966151
12white fat cell differentiation (GO:0050872)4.29489809
13macrophage activation involved in immune response (GO:0002281)4.18372229
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.10933483
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.10933483
16modulation by symbiont of host immune response (GO:0052553)4.10933483
17positive regulation by symbiont of host defense response (GO:0052509)4.10933483
18modulation by symbiont of host defense response (GO:0052031)4.10933483
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.10933483
20negative regulation of Ras GTPase activity (GO:0034261)4.10224337
21epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.97929371
22adenosine metabolic process (GO:0046085)3.96464992
23neutrophil mediated immunity (GO:0002446)3.95010968
24negative regulation of interleukin-1 beta production (GO:0032691)3.80305940
25leukotriene biosynthetic process (GO:0019370)3.77670717
26cellular extravasation (GO:0045123)3.75730416
27hepatocyte apoptotic process (GO:0097284)3.71758076
28microglial cell activation (GO:0001774)3.71137364
29interferon-gamma production (GO:0032609)3.61836733
30negative regulation of interleukin-1 production (GO:0032692)3.58237243
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.57121585
32regulation of interleukin-6 biosynthetic process (GO:0045408)3.50530222
33regulation of gamma-delta T cell activation (GO:0046643)3.44252253
34macrophage activation (GO:0042116)3.42050145
35alternative mRNA splicing, via spliceosome (GO:0000380)3.35880168
36regulation of vitamin D biosynthetic process (GO:0060556)3.35846966
37detection of external biotic stimulus (GO:0098581)3.33253789
38regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.32352113
39regulation of sequestering of triglyceride (GO:0010889)3.31966224
40myeloid leukocyte mediated immunity (GO:0002444)3.27736891
41cytidine metabolic process (GO:0046087)3.23752486
42cytidine catabolic process (GO:0006216)3.23752486
43cytidine deamination (GO:0009972)3.23752486
44folic acid-containing compound biosynthetic process (GO:0009396)3.22363446
45response to lipoprotein particle (GO:0055094)3.21945020
46regulation of gamma-delta T cell differentiation (GO:0045586)3.17862704
47energy homeostasis (GO:0097009)3.15568597
48muscle atrophy (GO:0014889)3.07297610
49negative regulation of interleukin-12 production (GO:0032695)3.07062512
50positive regulation of endothelial cell differentiation (GO:0045603)3.02825348
51negative regulation of DNA biosynthetic process (GO:2000279)3.02495496
52growth hormone secretion (GO:0030252)2.99529560
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98184320
54response to host immune response (GO:0052572)2.98184320
55desmosome organization (GO:0002934)2.95494544
56detection of biotic stimulus (GO:0009595)2.94929261
57positive regulation of B cell differentiation (GO:0045579)2.94169985
58DNA deamination (GO:0045006)2.93815107
59regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93770941
60organic cation transport (GO:0015695)2.92648089
61phosphatidylglycerol biosynthetic process (GO:0006655)2.91685041
62regulation of tight junction assembly (GO:2000810)2.90876488
63negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.90745496
64neutrophil activation involved in immune response (GO:0002283)2.90142948
65negative regulation of catenin import into nucleus (GO:0035414)2.89576390
66leukotriene metabolic process (GO:0006691)2.88597210
67adaptation of signaling pathway (GO:0023058)2.85626668
68neutrophil activation (GO:0042119)2.79333700
69protein-chromophore linkage (GO:0018298)2.78050982
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77772493
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77575315
72secretory granule organization (GO:0033363)2.77362631
73pyrimidine ribonucleoside catabolic process (GO:0046133)2.75644744
74response to peptidoglycan (GO:0032494)2.74014990
75alpha-beta T cell differentiation involved in immune response (GO:0002293)2.72355261
76alpha-beta T cell activation involved in immune response (GO:0002287)2.72355261
77T cell differentiation involved in immune response (GO:0002292)2.72355261
78monocyte differentiation (GO:0030224)2.72143594
79positive regulation of toll-like receptor signaling pathway (GO:0034123)2.70012398
80regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.68410429
81acrosome assembly (GO:0001675)2.65803948
82regulation of B cell receptor signaling pathway (GO:0050855)2.64847856
83negative regulation of cell killing (GO:0031342)2.58156014
84negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.58156014
85negative regulation of acute inflammatory response (GO:0002674)2.57454060
86positive regulation of mast cell activation (GO:0033005)2.56881661
87respiratory burst (GO:0045730)2.56659200
88regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.55104916
89myeloid cell activation involved in immune response (GO:0002275)2.52892027
90protein targeting to lysosome (GO:0006622)2.52181688
91establishment of protein localization to vacuole (GO:0072666)2.52181688
92protein targeting to vacuole (GO:0006623)2.52181688
93serine family amino acid biosynthetic process (GO:0009070)2.52071094
94regulation of regulatory T cell differentiation (GO:0045589)2.50701539
95galactose catabolic process (GO:0019388)2.50214779
96detection of other organism (GO:0098543)2.46078548
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.45443854
98response to host (GO:0075136)2.45443854
99response to host defenses (GO:0052200)2.45443854
100G-protein coupled receptor internalization (GO:0002031)2.44371448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.45226320
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.43637460
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.14598793
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65858801
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.47141155
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.94297848
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.89332383
8VDR_22108803_ChIP-Seq_LS180_Human2.82494028
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.79835858
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.53515199
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36906446
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29864855
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27550218
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.17337274
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09369805
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06976792
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06393214
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97715145
19RUNX_20019798_ChIP-Seq_JUKART_Human1.94205499
20MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86234582
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83417770
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83192514
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77484282
24SPI1_23547873_ChIP-Seq_NB4_Human1.73704527
25MYB_26560356_Chip-Seq_TH2_Human1.73597393
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68705425
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65467482
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58611876
29CDX2_22108803_ChIP-Seq_LS180_Human1.52314919
30MYB_26560356_Chip-Seq_TH1_Human1.46474313
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41305330
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40831319
33STAT1_20625510_ChIP-Seq_HELA_Human1.36728147
34SPI1_23127762_ChIP-Seq_K562_Human1.36451949
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32876833
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32876833
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32876833
38PU_27001747_Chip-Seq_BMDM_Mouse1.32751207
39VDR_24787735_ChIP-Seq_THP-1_Human1.32330387
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30096937
41GATA3_26560356_Chip-Seq_TH2_Human1.29453233
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29352407
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26589934
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25605010
45CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24102295
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22742929
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16667806
48GATA3_27048872_Chip-Seq_THYMUS_Human1.14901409
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.13079770
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08567855
51PRDM14_20953172_ChIP-Seq_ESCs_Human1.08500565
52SCL_19346495_ChIP-Seq_HPC-7_Human1.07393864
53TP53_22573176_ChIP-Seq_HFKS_Human1.04213482
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04166084
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03861349
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03317210
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02436498
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.02328622
59OCT1_27270436_Chip-Seq_PROSTATE_Human1.00342297
60RUNX1_22412390_ChIP-Seq_EML_Mouse0.97652470
61NCOR_22424771_ChIP-Seq_293T_Human0.97024764
62FOXH1_21741376_ChIP-Seq_EPCs_Human0.96939241
63OCT4_20526341_ChIP-Seq_ESCs_Human0.94779176
64RXR_22158963_ChIP-Seq_LIVER_Mouse0.94642154
65STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93802288
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93242466
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92511966
68GATA6_21074721_ChIP-Seq_CACO-2_Human0.91953082
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91022874
70GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.90668459
71CBP_20019798_ChIP-Seq_JUKART_Human0.90007040
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90007040
73GATA3_26560356_Chip-Seq_TH1_Human0.89565694
74MAF_26560356_Chip-Seq_TH1_Human0.88749490
75GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86245251
76TP53_16413492_ChIP-PET_HCT116_Human0.86141745
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86121494
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85749984
79PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85497614
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85371131
81HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82407003
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82351456
83RXR_22108803_ChIP-Seq_LS180_Human0.82317063
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81885023
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81331141
86HTT_18923047_ChIP-ChIP_STHdh_Human0.80528266
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80510520
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80419155
89MAF_26560356_Chip-Seq_TH2_Human0.80160449
90FLI1_21867929_ChIP-Seq_TH2_Mouse0.80001680
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79934134
92CEBPB_22108803_ChIP-Seq_LS180_Human0.79284973
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78465232
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78378617
95BCAT_22108803_ChIP-Seq_LS180_Human0.77694810
96SMRT_27268052_Chip-Seq_Bcells_Human0.77286987
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.77262458
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.76944704
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.76769112
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76458238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.35396914
2MP0005360_urolithiasis3.25145538
3MP0003183_abnormal_peptide_metabolism2.98696392
4MP0002138_abnormal_hepatobiliary_system2.84987683
5MP0003787_abnormal_imprinting2.79511976
6MP0008995_early_reproductive_senescence2.75619675
7MP0003705_abnormal_hypodermis_morpholog2.26666523
8MP0005646_abnormal_pituitary_gland2.22238170
9MP0003195_calcinosis2.20975323
10MP0003045_fibrosis2.18818450
11MP0000569_abnormal_digit_pigmentation2.11355759
12MP0003436_decreased_susceptibility_to2.07343157
13MP0000371_diluted_coat_color2.04661674
14MP0001800_abnormal_humoral_immune1.95447564
15MP0001835_abnormal_antigen_presentation1.94058847
16MP0002095_abnormal_skin_pigmentation1.93796098
17MP0004185_abnormal_adipocyte_glucose1.85063311
18MP0005085_abnormal_gallbladder_physiolo1.84839500
19MP0004510_myositis1.81876186
20MP0000013_abnormal_adipose_tissue1.78264236
21MP0003252_abnormal_bile_duct1.75364475
22MP0002419_abnormal_innate_immunity1.74630872
23MP0009764_decreased_sensitivity_to1.73695232
24MP0004130_abnormal_muscle_cell1.71629809
25MP0005671_abnormal_response_to1.68386440
26MP0008877_abnormal_DNA_methylation1.67953680
27MP0002736_abnormal_nociception_after1.66891138
28MP0002723_abnormal_immune_serum1.62975737
29MP0005464_abnormal_platelet_physiology1.62325809
30MP0005387_immune_system_phenotype1.59474347
31MP0001790_abnormal_immune_system1.59474347
32MP0005000_abnormal_immune_tolerance1.58389794
33MP0002166_altered_tumor_susceptibility1.55821410
34MP0001661_extended_life_span1.53328083
35MP0002006_tumorigenesis1.51626029
36MP0005025_abnormal_response_to1.48603348
37MP0004885_abnormal_endolymph1.46668450
38MP0003172_abnormal_lysosome_physiology1.45499948
39MP0002452_abnormal_antigen_presenting1.45365914
40MP0005670_abnormal_white_adipose1.44817700
41MP0002420_abnormal_adaptive_immunity1.42940532
42MP0005075_abnormal_melanosome_morpholog1.42054617
43MP0009785_altered_susceptibility_to1.41727536
44MP0001819_abnormal_immune_cell1.37092184
45MP0002822_catalepsy1.33378684
46MP0001845_abnormal_inflammatory_respons1.32277748
47MP0005164_abnormal_response_to1.31483007
48MP0002148_abnormal_hypersensitivity_rea1.27972445
49MP0003123_paternal_imprinting1.27130475
50MP0001533_abnormal_skeleton_physiology1.26640856
51MP0004381_abnormal_hair_follicle1.23741554
52MP0003191_abnormal_cellular_cholesterol1.20864268
53MP0004947_skin_inflammation1.17767788
54MP0002398_abnormal_bone_marrow1.17307608
55MP0004142_abnormal_muscle_tone1.16922359
56MP0002396_abnormal_hematopoietic_system1.15892005
57MP0000604_amyloidosis1.13282889
58MP0002277_abnormal_respiratory_mucosa1.11895571
59MP0000716_abnormal_immune_system1.11644447
60MP0008469_abnormal_protein_level1.09707753
61MP0002722_abnormal_immune_system1.09484792
62MP0005367_renal/urinary_system_phenotyp1.09277519
63MP0000516_abnormal_urinary_system1.09277519
64MP0000703_abnormal_thymus_morphology1.07231021
65MP0000689_abnormal_spleen_morphology1.06928256
66MP0001502_abnormal_circadian_rhythm1.06149127
67MP0001727_abnormal_embryo_implantation1.05746797
68MP0003763_abnormal_thymus_physiology1.05574153
69MP0001944_abnormal_pancreas_morphology1.01686328
70MP0005332_abnormal_amino_acid1.00157162
71MP0002078_abnormal_glucose_homeostasis0.98088756
72MP0005365_abnormal_bile_salt0.95169164
73MP0003646_muscle_fatigue0.94893960
74MP0000685_abnormal_immune_system0.93943235
75MP0005174_abnormal_tail_pigmentation0.93106392
76MP0005408_hypopigmentation0.92692539
77MP0003656_abnormal_erythrocyte_physiolo0.92205996
78MP0009115_abnormal_fat_cell0.91000883
79MP0002971_abnormal_brown_adipose0.90238766
80MP0003786_premature_aging0.89945844
81MP0002928_abnormal_bile_duct0.88580725
82MP0002693_abnormal_pancreas_physiology0.87284125
83MP0001666_abnormal_nutrient_absorption0.87087912
84MP0004883_abnormal_blood_vessel0.86863484
85MP0002429_abnormal_blood_cell0.86751922
86MP0009763_increased_sensitivity_to0.85837716
87MP0001968_abnormal_touch/_nociception0.85483983
88MP0008872_abnormal_physiological_respon0.85374596
89MP0008260_abnormal_autophagy0.85008496
90MP0005220_abnormal_exocrine_pancreas0.84171884
91MP0002075_abnormal_coat/hair_pigmentati0.83557330
92MP0005584_abnormal_enzyme/coenzyme_acti0.83003032
93MP0002332_abnormal_exercise_endurance0.81017182
94MP0002132_abnormal_respiratory_system0.80692003
95MP0000858_altered_metastatic_potential0.80338430
96MP0002405_respiratory_system_inflammati0.77991723
97MP0001851_eye_inflammation0.71606435
98MP0003866_abnormal_defecation0.70145995
99MP0009765_abnormal_xenobiotic_induced0.70035601
100MP0001756_abnormal_urination0.69297521

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)5.84424628
2Abnormality of alanine metabolism (HP:0010916)5.51014446
3Hyperalaninemia (HP:0003348)5.51014446
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.51014446
5Constricted visual fields (HP:0001133)4.68414799
6Esophageal varix (HP:0002040)4.40154541
7Anorexia (HP:0002039)4.16365398
8Congenital sensorineural hearing impairment (HP:0008527)4.16217830
9Elevated erythrocyte sedimentation rate (HP:0003565)3.90298883
10Recurrent bacterial skin infections (HP:0005406)3.89144786
11Pulmonary embolism (HP:0002204)3.74068011
12Conjugated hyperbilirubinemia (HP:0002908)3.69775935
13Myocardial infarction (HP:0001658)3.68323950
14Myositis (HP:0100614)3.66039049
15Recurrent abscess formation (HP:0002722)3.56231783
16Gingival bleeding (HP:0000225)3.55222043
17Action tremor (HP:0002345)3.43482098
18Conjunctival telangiectasia (HP:0000524)3.36764112
19Oligomenorrhea (HP:0000876)3.32513246
20Agitation (HP:0000713)3.25466236
21Decreased electroretinogram (ERG) amplitude (HP:0000654)3.24062382
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.23760584
23Arterial thrombosis (HP:0004420)3.20242241
24Fatigue (HP:0012378)3.04248898
25Abnormality of the vasculature of the conjunctiva (HP:0008054)2.89005200
26Thrombophlebitis (HP:0004418)2.85619058
27Retrobulbar optic neuritis (HP:0100654)2.76283526
28Optic neuritis (HP:0100653)2.76283526
29Homocystinuria (HP:0002156)2.73241463
30Abnormality of homocysteine metabolism (HP:0010919)2.73241463
31Peritonitis (HP:0002586)2.72249636
32Orchitis (HP:0100796)2.70550592
33Hemoptysis (HP:0002105)2.69811650
34Stomatitis (HP:0010280)2.65777231
35Insulin-resistant diabetes mellitus (HP:0000831)2.53605654
36Urticaria (HP:0001025)2.51710564
37T lymphocytopenia (HP:0005403)2.44198960
38White forelock (HP:0002211)2.40927268
39Epistaxis (HP:0000421)2.40443515
40Postural tremor (HP:0002174)2.38194111
41Microcytic anemia (HP:0001935)2.35182869
42Pustule (HP:0200039)2.34399942
43Abnormality of macrophages (HP:0004311)2.34278060
44Single umbilical artery (HP:0001195)2.31403108
45Abnormality of the fetal cardiovascular system (HP:0010948)2.31403108
46Abnormal umbilical cord blood vessels (HP:0011403)2.31403108
47Abnormality of T cell number (HP:0011839)2.31183400
48Poor speech (HP:0002465)2.30001135
49Joint hemorrhage (HP:0005261)2.29939580
50Genetic anticipation (HP:0003743)2.29718151
51Petechiae (HP:0000967)2.29414242
52Gastrointestinal infarctions (HP:0005244)2.28345130
53Progressive cerebellar ataxia (HP:0002073)2.23883992
54Hypoalphalipoproteinemia (HP:0003233)2.23465996
55Cone-rod dystrophy (HP:0000548)2.17956992
56Recurrent skin infections (HP:0001581)2.15788074
57Pancreatitis (HP:0001733)2.14352433
58Abnormality of pyrimidine metabolism (HP:0004353)2.10620722
59Patchy hypopigmentation of hair (HP:0011365)2.08577977
60Granulocytopenia (HP:0001913)2.02968312
61Premature graying of hair (HP:0002216)2.01844263
62Mediastinal lymphadenopathy (HP:0100721)2.00083523
63Eczematoid dermatitis (HP:0000976)1.99955805
64Recurrent gram-negative bacterial infections (HP:0005420)1.99824727
65Toxemia of pregnancy (HP:0100603)1.99486575
66Heterochromia iridis (HP:0001100)1.99118018
67Chronic otitis media (HP:0000389)1.98377110
68Leukocytosis (HP:0001974)1.98259159
69Pigmentary retinal degeneration (HP:0001146)1.96745052
70Attenuation of retinal blood vessels (HP:0007843)1.95562925
71Purpura (HP:0000979)1.95316398
72Recurrent cutaneous fungal infections (HP:0011370)1.93875577
73Chronic mucocutaneous candidiasis (HP:0002728)1.93875577
74Hemiplegia (HP:0002301)1.93631800
75Abnormal delayed hypersensitivity skin test (HP:0002963)1.93268719
76Hypergammaglobulinemia (HP:0010702)1.92501438
77Chorioretinal atrophy (HP:0000533)1.90747645
78Recurrent fungal infections (HP:0002841)1.89597232
79Abnormality of eosinophils (HP:0001879)1.86204139
80Gangrene (HP:0100758)1.85911903
81Abnormality of serum amino acid levels (HP:0003112)1.85587618
82Portal hypertension (HP:0001409)1.84654823
83Urinary bladder sphincter dysfunction (HP:0002839)1.83536626
84Chronic hepatic failure (HP:0100626)1.83280716
85Abnormality of the peritoneum (HP:0002585)1.81124710
86Clonus (HP:0002169)1.80770655
87Encephalitis (HP:0002383)1.78040714
88Meningitis (HP:0001287)1.77733126
89Maternal diabetes (HP:0009800)1.76203647
90Cavernous hemangioma (HP:0001048)1.75600619
91Vasculitis (HP:0002633)1.75517454
92Generalized aminoaciduria (HP:0002909)1.74551387
93Ketoacidosis (HP:0001993)1.72486161
94Hyperphosphatemia (HP:0002905)1.72191447
95Abnormality of the pericardium (HP:0001697)1.71883657
96Abnormality of sulfur amino acid metabolism (HP:0004339)1.70301920
97Pulmonary infiltrates (HP:0002113)1.69744004
98Palpebral edema (HP:0100540)1.69288750
99Biconcave vertebral bodies (HP:0004586)1.68357283
100Chronic diarrhea (HP:0002028)1.67398593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.16778883
2MAP2K33.86992332
3FGR3.03280089
4FRK2.99663679
5MAP4K22.88248323
6SGK22.87645800
7ACVR1B2.58014020
8SGK2232.55779264
9SGK4942.55779264
10PIK3CG2.44075825
11MAP3K112.38189881
12JAK32.38065103
13SGK32.17858395
14BLK2.10658293
15CAMKK21.68659723
16ERN11.58874415
17TXK1.57679017
18IRAK41.54688181
19YES11.54472804
20ITK1.53002130
21IKBKE1.50966309
22NTRK31.50808646
23PINK11.50015042
24TAOK31.45305986
25IRAK11.45077850
26CDK91.42059676
27BCKDK1.36703963
28MAP4K11.34312287
29MAP2K71.31874722
30NLK1.27958284
31WNK11.24997506
32TAOK11.23205536
33CAMK1D1.21969366
34RIPK41.19208202
35MAP3K21.18361806
36LRRK21.09997895
37TEC1.08945413
38CSK1.07613836
39MAP3K11.06250377
40JAK21.05532815
41SYK1.03915951
42ADRBK10.99991260
43PIM10.96792701
44SGK10.96567226
45MOS0.96106235
46DYRK1B0.95046586
47STK100.92127944
48CCNB10.90307245
49SCYL20.86334026
50NEK60.85880602
51IRAK20.80657257
52TNIK0.80144717
53TLK10.79440494
54TAOK20.78212735
55MAP3K140.76055599
56TRPM70.75995935
57NTRK20.74252919
58GRK70.73840855
59TYK20.73803112
60STK110.71538537
61HIPK20.71282651
62MAP3K60.70539511
63IKBKB0.70331849
64GRK60.69404202
65TNK20.69363837
66MAP3K50.68702904
67LMTK20.67533459
68PHKG20.67323362
69PHKG10.67323362
70AKT30.67311741
71CAMK1G0.65287462
72LYN0.61025858
73FGFR30.59459657
74RPS6KB20.55005552
75KDR0.54214861
76BTK0.53264068
77GRK50.53008117
78ZAP700.51878532
79MARK30.51513878
80LCK0.50421636
81KSR10.49300976
82HCK0.48061457
83BRD40.47438270
84DYRK30.45389273
85CAMK10.43584377
86WNK40.43582059
87TBK10.42752292
88MAP3K40.39793237
89PRKAA20.38946939
90PTK60.38433685
91MAPK70.38131266
92ERBB20.37970394
93CAMK40.37663279
94CSNK1A10.34964647
95CHUK0.33807051
96FES0.33227522
97EPHB10.31579550
98MAP2K40.31542960
99MAP2K10.30905113
100EPHA30.27531050

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.77665625
2Sulfur metabolism_Homo sapiens_hsa009203.27788838
3Collecting duct acid secretion_Homo sapiens_hsa049663.00245451
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.88046171
5Regulation of autophagy_Homo sapiens_hsa041402.55951853
6Staphylococcus aureus infection_Homo sapiens_hsa051501.93803165
7Osteoclast differentiation_Homo sapiens_hsa043801.85918458
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77811874
9Complement and coagulation cascades_Homo sapiens_hsa046101.74417077
10Arginine biosynthesis_Homo sapiens_hsa002201.73406838
11Morphine addiction_Homo sapiens_hsa050321.68037156
12Graft-versus-host disease_Homo sapiens_hsa053321.62638254
13Legionellosis_Homo sapiens_hsa051341.58941550
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.49845607
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.49088203
16Sulfur relay system_Homo sapiens_hsa041221.48722517
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47953668
18Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.46541947
19Rheumatoid arthritis_Homo sapiens_hsa053231.42492952
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41291155
21Type I diabetes mellitus_Homo sapiens_hsa049401.38060101
22Vibrio cholerae infection_Homo sapiens_hsa051101.32792562
23Tuberculosis_Homo sapiens_hsa051521.22643234
24Measles_Homo sapiens_hsa051621.22446989
25Fatty acid biosynthesis_Homo sapiens_hsa000611.22392967
26GABAergic synapse_Homo sapiens_hsa047271.22386521
27Allograft rejection_Homo sapiens_hsa053301.22375793
28T cell receptor signaling pathway_Homo sapiens_hsa046601.22147997
29Proteasome_Homo sapiens_hsa030501.21088623
30Autoimmune thyroid disease_Homo sapiens_hsa053201.20396258
31Dorso-ventral axis formation_Homo sapiens_hsa043201.19706558
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19185082
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15799344
34Galactose metabolism_Homo sapiens_hsa000521.11463544
35Leishmaniasis_Homo sapiens_hsa051401.10604550
36Linoleic acid metabolism_Homo sapiens_hsa005911.10457227
37Hematopoietic cell lineage_Homo sapiens_hsa046401.04802673
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04724919
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04468974
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04371220
41Serotonergic synapse_Homo sapiens_hsa047261.03652609
42Butanoate metabolism_Homo sapiens_hsa006501.01983023
43Synaptic vesicle cycle_Homo sapiens_hsa047210.96866913
44Chemokine signaling pathway_Homo sapiens_hsa040620.96438972
45Circadian rhythm_Homo sapiens_hsa047100.96330606
46Primary immunodeficiency_Homo sapiens_hsa053400.95813208
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92094183
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88487343
49Pancreatic secretion_Homo sapiens_hsa049720.87545775
50Olfactory transduction_Homo sapiens_hsa047400.85853088
51Phagosome_Homo sapiens_hsa041450.83488802
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83485424
53Oxidative phosphorylation_Homo sapiens_hsa001900.82843957
54Nicotine addiction_Homo sapiens_hsa050330.80199814
55One carbon pool by folate_Homo sapiens_hsa006700.79471862
56Antigen processing and presentation_Homo sapiens_hsa046120.79053610
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77085718
58Fat digestion and absorption_Homo sapiens_hsa049750.75677511
59Influenza A_Homo sapiens_hsa051640.74476385
60B cell receptor signaling pathway_Homo sapiens_hsa046620.73798978
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73215910
62TNF signaling pathway_Homo sapiens_hsa046680.72913758
63Cholinergic synapse_Homo sapiens_hsa047250.70107117
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66859745
65Ether lipid metabolism_Homo sapiens_hsa005650.63850550
66Thyroid cancer_Homo sapiens_hsa052160.62227927
67Epstein-Barr virus infection_Homo sapiens_hsa051690.62061058
68Pertussis_Homo sapiens_hsa051330.61703105
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61426529
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59454303
71Arachidonic acid metabolism_Homo sapiens_hsa005900.56260213
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56149242
73Glutamatergic synapse_Homo sapiens_hsa047240.55537006
74GnRH signaling pathway_Homo sapiens_hsa049120.55212840
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.54387846
76Platelet activation_Homo sapiens_hsa046110.53824644
77Dopaminergic synapse_Homo sapiens_hsa047280.52428132
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.51915008
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51486534
80Circadian entrainment_Homo sapiens_hsa047130.50834044
81Other glycan degradation_Homo sapiens_hsa005110.49331473
82Malaria_Homo sapiens_hsa051440.48111339
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47704640
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46930415
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46869022
86Glycerolipid metabolism_Homo sapiens_hsa005610.46156892
87Lysosome_Homo sapiens_hsa041420.45907801
88Retinol metabolism_Homo sapiens_hsa008300.45597551
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45040095
90Sphingolipid metabolism_Homo sapiens_hsa006000.44822900
91Nitrogen metabolism_Homo sapiens_hsa009100.44023399
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.42807589
93Apoptosis_Homo sapiens_hsa042100.42630529
94Systemic lupus erythematosus_Homo sapiens_hsa053220.42300321
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42187134
96Herpes simplex infection_Homo sapiens_hsa051680.41661548
97Insulin resistance_Homo sapiens_hsa049310.40804139
98Starch and sucrose metabolism_Homo sapiens_hsa005000.40218738
99RNA polymerase_Homo sapiens_hsa030200.40097626
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.39170928

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