PSMD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.04869106
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.04808349
3ribosomal small subunit assembly (GO:0000028)5.02790295
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.86346946
5ATP synthesis coupled proton transport (GO:0015986)4.86346946
6* proteasome assembly (GO:0043248)4.52066901
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.39402159
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.38844083
9mitochondrial respiratory chain complex assembly (GO:0033108)4.37832676
10respiratory electron transport chain (GO:0022904)4.20344444
11electron transport chain (GO:0022900)4.20164520
12behavioral response to nicotine (GO:0035095)4.18486959
13fucose catabolic process (GO:0019317)4.00811552
14L-fucose metabolic process (GO:0042354)4.00811552
15L-fucose catabolic process (GO:0042355)4.00811552
16respiratory chain complex IV assembly (GO:0008535)3.95771086
17viral transcription (GO:0019083)3.93405584
18platelet dense granule organization (GO:0060155)3.91061343
19tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.87227559
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.87227559
21ribosomal small subunit biogenesis (GO:0042274)3.83590891
22tRNA methylation (GO:0030488)3.82401610
23translational termination (GO:0006415)3.73264047
24maturation of SSU-rRNA (GO:0030490)3.72378605
25ribosomal large subunit biogenesis (GO:0042273)3.63492999
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.58715762
27telomere maintenance via semi-conservative replication (GO:0032201)3.57662807
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.55590814
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.51709646
30termination of RNA polymerase III transcription (GO:0006386)3.51709646
31mannosylation (GO:0097502)3.51308839
32cotranslational protein targeting to membrane (GO:0006613)3.50117329
33protein targeting to ER (GO:0045047)3.45414558
34cytochrome complex assembly (GO:0017004)3.42942436
35protein localization to endoplasmic reticulum (GO:0070972)3.34885236
36protein-cofactor linkage (GO:0018065)3.33084178
37rRNA modification (GO:0000154)3.28937302
38pseudouridine synthesis (GO:0001522)3.26764288
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22837487
40peptidyl-histidine modification (GO:0018202)3.22026112
41preassembly of GPI anchor in ER membrane (GO:0016254)3.19321002
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17417037
43piRNA metabolic process (GO:0034587)3.17333197
44telomere maintenance via recombination (GO:0000722)3.16326282
45hydrogen ion transmembrane transport (GO:1902600)3.15999071
46ubiquinone metabolic process (GO:0006743)3.12960918
47iron-sulfur cluster assembly (GO:0016226)3.12600171
48metallo-sulfur cluster assembly (GO:0031163)3.12600171
49translational elongation (GO:0006414)3.12329339
50protein deneddylation (GO:0000338)3.11773905
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11208602
52protein neddylation (GO:0045116)3.08626277
53kynurenine metabolic process (GO:0070189)3.07817005
54negative regulation of telomere maintenance (GO:0032205)3.07024640
55base-excision repair, AP site formation (GO:0006285)3.07004424
56response to folic acid (GO:0051593)3.05688395
57positive regulation of prostaglandin secretion (GO:0032308)3.04543732
58DNA ligation (GO:0006266)3.03718834
59DNA replication initiation (GO:0006270)3.03624742
60purine nucleoside triphosphate biosynthetic process (GO:0009145)3.02701979
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02290972
62proton transport (GO:0015992)3.01094131
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99281463
64RNA methylation (GO:0001510)2.99223713
65facial nerve structural organization (GO:0021612)2.98843034
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.98606392
67CENP-A containing nucleosome assembly (GO:0034080)2.98326283
68cullin deneddylation (GO:0010388)2.96185501
69water-soluble vitamin biosynthetic process (GO:0042364)2.94877937
707-methylguanosine mRNA capping (GO:0006370)2.94300039
71hydrogen transport (GO:0006818)2.92478410
72translation (GO:0006412)2.91835820
73pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91810607
74RNA capping (GO:0036260)2.90791973
757-methylguanosine RNA capping (GO:0009452)2.90791973
76DNA strand elongation involved in DNA replication (GO:0006271)2.90754686
77tRNA modification (GO:0006400)2.90014501
78chaperone-mediated protein transport (GO:0072321)2.89262044
79DNA damage response, detection of DNA damage (GO:0042769)2.88090586
80* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87847336
81viral life cycle (GO:0019058)2.87718575
82L-methionine salvage (GO:0071267)2.87518745
83L-methionine biosynthetic process (GO:0071265)2.87518745
84amino acid salvage (GO:0043102)2.87518745
85intracellular protein transmembrane import (GO:0044743)2.87099398
86DNA strand elongation (GO:0022616)2.85270815
87ATP biosynthetic process (GO:0006754)2.84573390
88cellular ketone body metabolic process (GO:0046950)2.83240548
89translational initiation (GO:0006413)2.82106161
90indolalkylamine metabolic process (GO:0006586)2.82096019
91telomere maintenance via telomere lengthening (GO:0010833)2.81190668
92ribonucleoprotein complex biogenesis (GO:0022613)2.80867371
93indolalkylamine catabolic process (GO:0046218)2.80586573
94tryptophan catabolic process (GO:0006569)2.80586573
95indole-containing compound catabolic process (GO:0042436)2.80586573
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79867495
97replication fork processing (GO:0031297)2.79575219
98rRNA methylation (GO:0031167)2.78607353
99chromatin remodeling at centromere (GO:0031055)2.78541582
100UTP biosynthetic process (GO:0006228)2.77839873
101heme biosynthetic process (GO:0006783)2.77778166
102establishment of protein localization to mitochondrion (GO:0072655)2.77235899
103cellular protein complex disassembly (GO:0043624)2.77176626
104protein targeting to mitochondrion (GO:0006626)2.75763626
105UTP metabolic process (GO:0046051)2.75362024
106kinetochore assembly (GO:0051382)2.74977239
107DNA catabolic process, exonucleolytic (GO:0000738)2.74683521
108signal peptide processing (GO:0006465)2.73013379
109response to interferon-beta (GO:0035456)2.71771213
110* regulation of cellular amino acid metabolic process (GO:0006521)2.71684896
111protein complex biogenesis (GO:0070271)2.71524290
112* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68736940
113ketone body metabolic process (GO:1902224)2.67573664
114deoxyribonucleotide catabolic process (GO:0009264)2.66848900
115DNA replication checkpoint (GO:0000076)2.66830482
116rRNA processing (GO:0006364)2.66083134
117transcription-coupled nucleotide-excision repair (GO:0006283)2.66029927
118maturation of 5.8S rRNA (GO:0000460)2.65755793
119mitotic recombination (GO:0006312)2.65543844
120* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.65232617
121mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64391748
122mitochondrial respiratory chain complex I assembly (GO:0032981)2.64391748
123NADH dehydrogenase complex assembly (GO:0010257)2.64391748
124RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64347913
125cellular component biogenesis (GO:0044085)2.64169347
126GTP biosynthetic process (GO:0006183)2.62208185
127protein localization to mitochondrion (GO:0070585)2.61345290
128heme metabolic process (GO:0042168)2.60536876
129* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60372999
130* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.58959308
131pyrimidine nucleotide catabolic process (GO:0006244)2.58868200
132* negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57994569
133* negative regulation of ligase activity (GO:0051352)2.57994569
134tRNA processing (GO:0008033)2.57960306
135protein K6-linked ubiquitination (GO:0085020)2.57677062
136* signal transduction involved in DNA integrity checkpoint (GO:0072401)2.57093313
137* signal transduction involved in DNA damage checkpoint (GO:0072422)2.57093313
138* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.56219119
139* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.55723106
140* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.55723106
141* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.55723106
142GPI anchor biosynthetic process (GO:0006506)2.55610248
143quinone biosynthetic process (GO:1901663)2.55545992
144ubiquinone biosynthetic process (GO:0006744)2.55545992
145rRNA metabolic process (GO:0016072)2.54817035
146mitochondrial RNA metabolic process (GO:0000959)2.54467549
147spliceosomal snRNP assembly (GO:0000387)2.54113398
148* signal transduction involved in cell cycle checkpoint (GO:0072395)2.54067882
149* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.53449905
150* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.53449905
151lymphoid progenitor cell differentiation (GO:0002320)2.52402992
152centriole assembly (GO:0098534)2.51882782
153regulation of mitochondrial translation (GO:0070129)2.51444530
154RNA modification (GO:0009451)2.50975349
155omega-hydroxylase P450 pathway (GO:0097267)2.50222411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.30384771
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.22837291
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.17902016
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.79360892
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.74378113
6ZNF274_21170338_ChIP-Seq_K562_Hela3.54780485
7E2F7_22180533_ChIP-Seq_HELA_Human3.51489544
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.41685254
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.32659054
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15486709
11* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95916336
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.90679508
13VDR_22108803_ChIP-Seq_LS180_Human2.86563883
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77399698
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76511519
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73702692
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.61423635
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.60963555
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55563508
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43603270
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39544918
22* VDR_23849224_ChIP-Seq_CD4+_Human2.37458354
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27809149
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24666848
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.24318872
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24314535
27EGR1_23403033_ChIP-Seq_LIVER_Mouse2.21496757
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20685175
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18176507
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12347102
31IRF1_19129219_ChIP-ChIP_H3396_Human2.11543261
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02566684
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.00078501
34* FOXP3_21729870_ChIP-Seq_TREG_Human1.94782339
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.94077192
36DCP1A_22483619_ChIP-Seq_HELA_Human1.90290351
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83467947
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.81795182
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81651992
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78985815
41XRN2_22483619_ChIP-Seq_HELA_Human1.77208958
42* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.76460546
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75005208
44ELK1_19687146_ChIP-ChIP_HELA_Human1.74874868
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73431356
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71847370
47SCL_19346495_ChIP-Seq_HPC-7_Human1.70956489
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69858065
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68651480
50TP53_22573176_ChIP-Seq_HFKS_Human1.68634151
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66999398
52* GABP_19822575_ChIP-Seq_HepG2_Human1.65506676
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65506061
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64438574
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63875223
56EWS_26573619_Chip-Seq_HEK293_Human1.60943441
57MYC_18940864_ChIP-ChIP_HL60_Human1.56133772
58TTF2_22483619_ChIP-Seq_HELA_Human1.56010380
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53404627
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52477682
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46744092
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.46296365
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46296365
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45949022
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.45706164
66EZH2_22144423_ChIP-Seq_EOC_Human1.45134724
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44137442
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43292258
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.40507908
70* AR_20517297_ChIP-Seq_VCAP_Human1.37716870
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.31720376
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31231957
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30732160
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29749085
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28443124
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26988606
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26684034
78ERA_21632823_ChIP-Seq_H3396_Human1.20689719
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19839598
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19520267
81SPI1_23547873_ChIP-Seq_NB4_Human1.18704040
82* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17752154
83NCOR_22424771_ChIP-Seq_293T_Human1.15649020
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15483809
85TAF2_19829295_ChIP-Seq_ESCs_Human1.15064313
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14488364
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.14247807
88NANOG_20526341_ChIP-Seq_ESCs_Human1.14241703
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13898476
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13719628
91HOXB7_26014856_ChIP-Seq_BT474_Human1.13111961
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11943027
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.09153713
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09087932
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08470864
96FOXH1_21741376_ChIP-Seq_EPCs_Human1.07871380
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07263818
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06992542
99NANOG_19829295_ChIP-Seq_ESCs_Human1.06747167
100SOX2_19829295_ChIP-Seq_ESCs_Human1.06747167
101FUS_26573619_Chip-Seq_HEK293_Human1.06641230
102ER_23166858_ChIP-Seq_MCF-7_Human1.05174880
103ELK1_22589737_ChIP-Seq_MCF10A_Human1.03740459
104PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03630054
105IRF8_22096565_ChIP-ChIP_GC-B_Human1.03431057
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03361338
107IGF1R_20145208_ChIP-Seq_DFB_Human1.00933689
108STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00487076
109MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99625800
110ERG_20517297_ChIP-Seq_VCAP_Human0.98866701
111STAT1_20625510_ChIP-Seq_HELA_Human0.98706780
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98113950
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96713844
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95298861
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95037475
116P300_19829295_ChIP-Seq_ESCs_Human0.94378317
117ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94348771
118P53_21459846_ChIP-Seq_SAOS-2_Human0.94010401
119NFE2_27457419_Chip-Seq_LIVER_Mouse0.93843981
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93820549
121FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93195279
122GBX2_23144817_ChIP-Seq_PC3_Human0.93049240
123MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92826878
124CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91056913
125MYC_19829295_ChIP-Seq_ESCs_Human0.90694099
126* KDM5A_27292631_Chip-Seq_BREAST_Human0.90687128
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90004074
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89838827
129IRF8_21731497_ChIP-ChIP_J774_Mouse0.89180843
130GATA3_26560356_Chip-Seq_TH2_Human0.88480305
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87730424
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86411936
133E2F1_21310950_ChIP-Seq_MCF-7_Human0.86056326
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85780104
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83966160
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83851552
137ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83780428
138CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83521736
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82023184
140CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81357760
141GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80922461
142* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79990439
143POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79425590
144YY1_22570637_ChIP-Seq_MALME-3M_Human0.79288808
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76560871
146YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75401859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.81929184
2MP0006292_abnormal_olfactory_placode3.61821025
3MP0009379_abnormal_foot_pigmentation3.54555529
4MP0003693_abnormal_embryo_hatching2.71996503
5MP0003718_maternal_effect2.63541738
6MP0004381_abnormal_hair_follicle2.58974329
7MP0000569_abnormal_digit_pigmentation2.48949083
8MP0002837_dystrophic_cardiac_calcinosis2.46443895
9MP0001188_hyperpigmentation2.41894196
10MP0008058_abnormal_DNA_repair2.36692289
11MP0005409_darkened_coat_color2.26143726
12MP0005551_abnormal_eye_electrophysiolog2.11235431
13MP0000372_irregular_coat_pigmentation2.07098307
14MP0002736_abnormal_nociception_after2.06777834
15MP0005075_abnormal_melanosome_morpholog2.01552876
16MP0005451_abnormal_body_composition1.98596619
17MP0003656_abnormal_erythrocyte_physiolo1.97517031
18MP0003186_abnormal_redox_activity1.93699905
19MP0003724_increased_susceptibility_to1.91971018
20MP0010094_abnormal_chromosome_stability1.91414971
21MP0002102_abnormal_ear_morphology1.91373872
22MP0006072_abnormal_retinal_apoptosis1.90638301
23MP0008260_abnormal_autophagy1.90617660
24MP0001968_abnormal_touch/_nociception1.88751328
25MP0005174_abnormal_tail_pigmentation1.88644353
26MP0009697_abnormal_copulation1.86079645
27MP0000015_abnormal_ear_pigmentation1.84229777
28MP0008877_abnormal_DNA_methylation1.79533605
29MP0002095_abnormal_skin_pigmentation1.75849841
30MP0003111_abnormal_nucleus_morphology1.75746180
31MP0002132_abnormal_respiratory_system1.72564342
32MP0008872_abnormal_physiological_respon1.72019157
33MP0003011_delayed_dark_adaptation1.70413910
34MP0003950_abnormal_plasma_membrane1.69597553
35MP0002396_abnormal_hematopoietic_system1.67426408
36MP0008007_abnormal_cellular_replicative1.67377158
37MP0003806_abnormal_nucleotide_metabolis1.64431245
38MP0009785_altered_susceptibility_to1.64260642
39MP0003077_abnormal_cell_cycle1.60996964
40MP0005253_abnormal_eye_physiology1.58315711
41MP0000427_abnormal_hair_cycle1.56674531
42MP0008932_abnormal_embryonic_tissue1.54722253
43MP0000490_abnormal_crypts_of1.53421047
44MP0004147_increased_porphyrin_level1.52414406
45MP0009333_abnormal_splenocyte_physiolog1.50868865
46MP0002138_abnormal_hepatobiliary_system1.47695252
47MP0005084_abnormal_gallbladder_morpholo1.47390464
48MP0001986_abnormal_taste_sensitivity1.47167692
49MP0003786_premature_aging1.45912408
50MP0000566_synostosis1.45528878
51MP0002139_abnormal_hepatobiliary_system1.44770799
52MP0002234_abnormal_pharynx_morphology1.41773979
53MP0002163_abnormal_gland_morphology1.39836462
54MP0004957_abnormal_blastocyst_morpholog1.36686568
55MP0004133_heterotaxia1.34913944
56MP0010386_abnormal_urinary_bladder1.34571434
57MP0002148_abnormal_hypersensitivity_rea1.34459898
58MP0009046_muscle_twitch1.34323736
59MP0002938_white_spotting1.33609015
60MP0001835_abnormal_antigen_presentation1.32731525
61MP0002653_abnormal_ependyma_morphology1.31354152
62MP0005171_absent_coat_pigmentation1.31200158
63MP0006035_abnormal_mitochondrial_morpho1.31151453
64MP0003763_abnormal_thymus_physiology1.27784650
65MP0005646_abnormal_pituitary_gland1.25879151
66MP0002638_abnormal_pupillary_reflex1.25614916
67MP0002277_abnormal_respiratory_mucosa1.23796376
68MP0005671_abnormal_response_to1.23128054
69MP0001764_abnormal_homeostasis1.21887716
70MP0005645_abnormal_hypothalamus_physiol1.20229082
71MP0001324_abnormal_eye_pigmentation1.19673567
72MP0005408_hypopigmentation1.19480558
73MP0005025_abnormal_response_to1.18727848
74MP0002249_abnormal_larynx_morphology1.18281941
75MP0002876_abnormal_thyroid_physiology1.17626678
76MP0000465_gastrointestinal_hemorrhage1.15729927
77MP0001919_abnormal_reproductive_system1.15513807
78MP0001529_abnormal_vocalization1.14230003
79MP0003315_abnormal_perineum_morphology1.13097798
80MP0004043_abnormal_pH_regulation1.11676007
81MP0006036_abnormal_mitochondrial_physio1.10428151
82MP0005410_abnormal_fertilization1.06222532
83MP0001485_abnormal_pinna_reflex1.05261427
84MP0001119_abnormal_female_reproductive1.05156886
85MP0004885_abnormal_endolymph1.04923321
86MP0003436_decreased_susceptibility_to1.04266969
87MP0001853_heart_inflammation1.01783934
88MP0008995_early_reproductive_senescence1.01737227
89MP0004742_abnormal_vestibular_system1.01468938
90MP0000049_abnormal_middle_ear1.01087694
91MP0002177_abnormal_outer_ear0.97980186
92MP0002210_abnormal_sex_determination0.97930805
93MP0004782_abnormal_surfactant_physiolog0.97279850
94MP0005332_abnormal_amino_acid0.96998896
95MP0005389_reproductive_system_phenotype0.96705950
96MP0000685_abnormal_immune_system0.96503943
97MP0005377_hearing/vestibular/ear_phenot0.95369279
98MP0003878_abnormal_ear_physiology0.95369279
99MP0002419_abnormal_innate_immunity0.94833712
100MP0000358_abnormal_cell_content/0.94171435
101MP0005085_abnormal_gallbladder_physiolo0.93555326
102MP0005000_abnormal_immune_tolerance0.93423816
103MP0002723_abnormal_immune_serum0.93402725
104MP0002160_abnormal_reproductive_system0.93119954
105MP0005397_hematopoietic_system_phenotyp0.92831647
106MP0001545_abnormal_hematopoietic_system0.92831647
107MP0000647_abnormal_sebaceous_gland0.92347378
108MP0000689_abnormal_spleen_morphology0.90781777
109MP0003646_muscle_fatigue0.90430229
110MP0009745_abnormal_behavioral_response0.89577117
111MP0006276_abnormal_autonomic_nervous0.87999066
112MP0005464_abnormal_platelet_physiology0.87738128
113MP0002735_abnormal_chemical_nociception0.86201851
114MP0009764_decreased_sensitivity_to0.86179235
115MP0000613_abnormal_salivary_gland0.85366077
116MP0001800_abnormal_humoral_immune0.85223589
117MP0008469_abnormal_protein_level0.84978556
118MP0002398_abnormal_bone_marrow0.83571276
119MP0002452_abnormal_antigen_presenting0.83242468
120MP0000538_abnormal_urinary_bladder0.83225474
121MP0000631_abnormal_neuroendocrine_gland0.83004453
122MP0005360_urolithiasis0.82678855
123MP0004142_abnormal_muscle_tone0.80427245
124MP0002420_abnormal_adaptive_immunity0.80384138
125MP0001819_abnormal_immune_cell0.80250774
126MP0005195_abnormal_posterior_eye0.80191236
127MP0000681_abnormal_thyroid_gland0.79439160
128MP0004145_abnormal_muscle_electrophysio0.79433013
129MP0001501_abnormal_sleep_pattern0.78701283
130MP0002272_abnormal_nervous_system0.78650032
131MP0008789_abnormal_olfactory_epithelium0.78023364
132MP0008875_abnormal_xenobiotic_pharmacok0.77742776
133MP0005266_abnormal_metabolism0.77620929
134MP0002722_abnormal_immune_system0.77422976
135MP0000230_abnormal_systemic_arterial0.76836610
136MP0005379_endocrine/exocrine_gland_phen0.76190510
137MP0001905_abnormal_dopamine_level0.75738728
138MP0005395_other_phenotype0.75557308
139MP0010030_abnormal_orbit_morphology0.74834237
140MP0003137_abnormal_impulse_conducting0.74821976
141MP0000716_abnormal_immune_system0.73927201
142MP0005636_abnormal_mineral_homeostasis0.73735859
143MP0000653_abnormal_sex_gland0.73712396
144MP0002429_abnormal_blood_cell0.73210124
145MP0001929_abnormal_gametogenesis0.73149031
146MP0003698_abnormal_male_reproductive0.73089403
147MP0003195_calcinosis0.72526481
148MP0002019_abnormal_tumor_incidence0.72154116
149MP0009840_abnormal_foam_cell0.72067609
150MP0004019_abnormal_vitamin_homeostasis0.71352990
151MP0000858_altered_metastatic_potential0.71249558

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.17803675
2Abnormal number of erythroid precursors (HP:0012131)4.04217149
3Aplasia/Hypoplasia of the sacrum (HP:0008517)4.04169509
4Abnormality of cells of the erythroid lineage (HP:0012130)4.00501684
5Pancreatic cysts (HP:0001737)3.97482545
6Type I transferrin isoform profile (HP:0003642)3.96569282
7Molar tooth sign on MRI (HP:0002419)3.92533941
8Abnormality of midbrain morphology (HP:0002418)3.92533941
9Reduced antithrombin III activity (HP:0001976)3.87081385
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.65230914
11Progressive macrocephaly (HP:0004481)3.52927771
12Pancreatic fibrosis (HP:0100732)3.52440020
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.35984776
14Abnormality of alanine metabolism (HP:0010916)3.35984776
15Hyperalaninemia (HP:0003348)3.35984776
16Congenital stationary night blindness (HP:0007642)3.33093359
17Aplastic anemia (HP:0001915)3.18017224
18Reticulocytopenia (HP:0001896)3.16568740
19Hepatocellular necrosis (HP:0001404)3.15282566
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12905804
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.11126689
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.10656056
23Type 2 muscle fiber atrophy (HP:0003554)3.07799229
24Nonprogressive disorder (HP:0003680)3.00340198
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00045504
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00045504
27Congenital, generalized hypertrichosis (HP:0004540)2.94135553
28Chromsome breakage (HP:0040012)2.93796439
29Nephronophthisis (HP:0000090)2.92382984
30Renal Fanconi syndrome (HP:0001994)2.91597580
31Hepatic necrosis (HP:0002605)2.90699250
32Increased hepatocellular lipid droplets (HP:0006565)2.90233128
33Abnormality of the axillary hair (HP:0100134)2.85044990
34Abnormality of secondary sexual hair (HP:0009888)2.85044990
35Abnormal protein glycosylation (HP:0012346)2.81325845
36Abnormal glycosylation (HP:0012345)2.81325845
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.81325845
38Abnormal protein N-linked glycosylation (HP:0012347)2.81325845
39Mitochondrial inheritance (HP:0001427)2.80770937
40Muscle fiber atrophy (HP:0100295)2.77868637
41Type II lissencephaly (HP:0007260)2.77283914
42Abnormality of the renal cortex (HP:0011035)2.71618330
43Concave nail (HP:0001598)2.63014361
44Medial flaring of the eyebrow (HP:0010747)2.59852454
45Birth length less than 3rd percentile (HP:0003561)2.55375113
46Macrocytic anemia (HP:0001972)2.51554747
47Exertional dyspnea (HP:0002875)2.51049477
48Lipid accumulation in hepatocytes (HP:0006561)2.50929950
49Generalized aminoaciduria (HP:0002909)2.49690239
50Abnormality of the pons (HP:0007361)2.49499490
51Microvesicular hepatic steatosis (HP:0001414)2.44134104
52Pallor (HP:0000980)2.44115140
53Meckel diverticulum (HP:0002245)2.41632611
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40953488
55Petechiae (HP:0000967)2.40835270
56Acute necrotizing encephalopathy (HP:0006965)2.38901981
57Abnormality of the renal medulla (HP:0100957)2.38671326
58Sclerocornea (HP:0000647)2.38513879
59Abnormality of the preputium (HP:0100587)2.37993609
60Attenuation of retinal blood vessels (HP:0007843)2.37395785
61Increased CSF lactate (HP:0002490)2.37126124
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36619166
63Large for gestational age (HP:0001520)2.35142046
64Prolonged neonatal jaundice (HP:0006579)2.34827488
65Increased serum lactate (HP:0002151)2.33407679
66Hypoplasia of the pons (HP:0012110)2.32254026
67Dry hair (HP:0011359)2.28721822
68Prolonged partial thromboplastin time (HP:0003645)2.28048088
69Abnormality of the ileum (HP:0001549)2.25821658
70Furrowed tongue (HP:0000221)2.24356553
71Adrenal hypoplasia (HP:0000835)2.23537379
72Respiratory failure (HP:0002878)2.23301189
73Pancytopenia (HP:0001876)2.22134673
74Renal cortical cysts (HP:0000803)2.20184682
75Microcytic anemia (HP:0001935)2.19749836
76Abnormality of urine glucose concentration (HP:0011016)2.18034835
77Glycosuria (HP:0003076)2.18034835
78CNS demyelination (HP:0007305)2.12828999
79Increased intramyocellular lipid droplets (HP:0012240)2.12373082
80Patchy hypopigmentation of hair (HP:0011365)2.12066619
81Pendular nystagmus (HP:0012043)2.11808869
82Tubular atrophy (HP:0000092)2.11122205
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.10527729
84Lethargy (HP:0001254)2.10136331
85Cystic liver disease (HP:0006706)2.09374567
86Abnormal lung lobation (HP:0002101)2.07461354
87Prolonged bleeding time (HP:0003010)2.07449634
88Supernumerary spleens (HP:0009799)2.06455153
89Abnormal mitochondria in muscle tissue (HP:0008316)2.03610280
90Parakeratosis (HP:0001036)2.03305652
91Optic disc pallor (HP:0000543)2.03252566
92Chronic hepatic failure (HP:0100626)2.01258859
93Acute encephalopathy (HP:0006846)2.00594987
94Abnormality of pyrimidine metabolism (HP:0004353)2.00116190
95Abnormality of renal resorption (HP:0011038)1.98595026
96Severe muscular hypotonia (HP:0006829)1.98517294
97Sparse eyelashes (HP:0000653)1.98066473
98Clubbing of toes (HP:0100760)1.97595417
99Anencephaly (HP:0002323)1.97570697
100Cerebellar dysplasia (HP:0007033)1.96602302
101Microretrognathia (HP:0000308)1.96539843
102Oral leukoplakia (HP:0002745)1.96462378
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.96055949
104Congenital primary aphakia (HP:0007707)1.95124810
105Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94189793
106Breast hypoplasia (HP:0003187)1.93884771
107Patellar aplasia (HP:0006443)1.93110037
108Aplasia/Hypoplasia of the patella (HP:0006498)1.92999817
109Congenital hepatic fibrosis (HP:0002612)1.90338968
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.89559298
111Absent/shortened dynein arms (HP:0200106)1.89559298
112Aplasia/hypoplasia of the uterus (HP:0008684)1.89259728
113Progressive microcephaly (HP:0000253)1.88657524
114Abnormality of the prostate (HP:0008775)1.88111848
115Absent thumb (HP:0009777)1.87555437
116Male pseudohermaphroditism (HP:0000037)1.87350173
117Triphalangeal thumb (HP:0001199)1.87161861
118Joint hemorrhage (HP:0005261)1.86938488
119Lactic acidosis (HP:0003128)1.86386148
120Severe visual impairment (HP:0001141)1.85940671
121Hypoplasia of the fovea (HP:0007750)1.85743948
122Aplasia/Hypoplasia of the fovea (HP:0008060)1.85743948
123Abnormality of chromosome stability (HP:0003220)1.85696533
124Gait imbalance (HP:0002141)1.84589536
125Methylmalonic aciduria (HP:0012120)1.84547710
126Opisthotonus (HP:0002179)1.84201343
127Nephrogenic diabetes insipidus (HP:0009806)1.84018407
128Split foot (HP:0001839)1.83344276
129Thyroid-stimulating hormone excess (HP:0002925)1.82985506
130True hermaphroditism (HP:0010459)1.82975290
131Retinal dysplasia (HP:0007973)1.82957047
132Abnormal rod and cone electroretinograms (HP:0008323)1.81588842
133White forelock (HP:0002211)1.80816483
134Premature graying of hair (HP:0002216)1.79338493
135Renal tubular dysfunction (HP:0000124)1.77826648
136Recurrent abscess formation (HP:0002722)1.77521970
137Bone marrow hypocellularity (HP:0005528)1.76895053
138Constricted visual fields (HP:0001133)1.76747715
139Short tibia (HP:0005736)1.76660394
140Bile duct proliferation (HP:0001408)1.76650839
141Abnormal biliary tract physiology (HP:0012439)1.76650839
142Hypergonadotropic hypogonadism (HP:0000815)1.75441237
143Cerebral edema (HP:0002181)1.74907363
144Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73784816
145Rough bone trabeculation (HP:0100670)1.73178970
146Exercise intolerance (HP:0003546)1.71574427
147Nausea (HP:0002018)1.71232418
148Sex reversal (HP:0012245)1.69939373
149Abnormal sex determination (HP:0012244)1.69939373
150Aplasia/Hypoplasia of the tibia (HP:0005772)1.67791332
151Duplicated collecting system (HP:0000081)1.67709759
152Duodenal stenosis (HP:0100867)1.67097716
153Small intestinal stenosis (HP:0012848)1.67097716
154Respiratory difficulties (HP:0002880)1.66576774
155Increased muscle lipid content (HP:0009058)1.66037757
156Hypothermia (HP:0002045)1.65754981
157Myelodysplasia (HP:0002863)1.64592881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.63648851
2FRK3.89786905
3SRPK13.74728057
4STK163.65191701
5NME23.54153007
6VRK23.15602505
7BUB13.04013351
8CASK2.67135552
9MAP3K122.56026270
10TLK12.47910417
11TNIK2.47651157
12MKNK22.39751755
13VRK11.94602484
14MKNK11.94263642
15PLK41.87071593
16EIF2AK11.82044931
17IRAK31.79239931
18IRAK41.78424751
19MAPKAPK31.75399617
20WEE11.74904068
21EIF2AK31.73813945
22PIM21.68297240
23TXK1.58570002
24ZAK1.55015311
25BLK1.52554287
26WNK41.51284644
27NLK1.47253673
28ADRBK11.45435267
29TRIM281.43160597
30TEC1.39751105
31CLK11.36543868
32DYRK31.34159479
33INSRR1.33983000
34WNK31.33008666
35EIF2AK21.32986301
36LIMK11.27101572
37MAP4K21.22490114
38MST41.19774779
39CDK81.15831466
40NUAK11.13997348
41PINK11.11354965
42IRAK11.10803810
43PBK1.09848291
44CDK71.08899363
45CDK191.08753425
46KDR1.03520140
47BMPR1B1.02743233
48GRK11.00818901
49CAMKK20.99890690
50MAP4K10.99403211
51CSNK1G10.98520595
52YES10.97473946
53DYRK20.95807350
54MYLK0.93723707
55RPS6KA40.92578954
56ADRBK20.92211951
57IKBKB0.92021077
58PIM10.91155344
59PLK30.91028373
60BCKDK0.89153120
61BTK0.89115361
62AURKA0.89095057
63CDK30.88901129
64KIT0.87866289
65NEK10.87191807
66CSNK1G20.83140679
67ACVR1B0.83049205
68MAP3K110.81964001
69TESK20.81594734
70PLK10.81570526
71IKBKE0.81327742
72MAP3K140.80500877
73IRAK20.78886146
74BMPR20.78841318
75RPS6KA50.77980552
76AURKB0.76946935
77PRKCI0.75192335
78PDK20.72403363
79PTK2B0.72372379
80CSNK1G30.70653749
81PIK3CG0.68869049
82BRAF0.68650333
83DAPK20.67156126
84OXSR10.66678881
85MAPKAPK50.66666793
86NEK60.63483709
87CSNK2A10.60014380
88ABL20.59738130
89ILK0.59193226
90TTK0.59130040
91MAPK130.59069607
92DAPK10.58785888
93LYN0.57788069
94CCNB10.57008525
95CHEK20.56804428
96MARK30.56794080
97NME10.56543346
98PRKCE0.55708429
99BRSK20.54996374
100TBK10.53756147
101PRKG20.52840244
102PKN10.51090381
103TAOK20.51005276
104MAP2K70.50315278
105BRSK10.49632589
106TGFBR10.49405341
107PRKCG0.49219139
108TIE10.49167543
109ATR0.47258596
110TAOK30.47023110
111NEK20.44459563
112TRPM70.44081381
113DAPK30.43810983
114CHUK0.43369514
115CDK40.43296968
116CDC70.42690893
117PRPF4B0.42370435
118MAPK40.42331569
119STK40.42184754
120EPHA20.41608175
121PRKCQ0.41158052
122MAPK150.40395421
123GRK70.39992442
124CSNK1A1L0.39192319
125CSNK2A20.38543465
126PRKD20.37400009
127MAP3K60.36844524
128MAP3K40.36378745
129PAK10.35751886
130ERBB40.34229491
131ZAP700.33159502
132STK390.33018126
133SYK0.32221144
134TNK20.31296026
135CAMK2A0.31061562
136PAK30.31000680
137PRKACA0.29841479
138MAP2K60.29824885
139CSNK1A10.29688943
140STK38L0.29582070
141TESK10.27989855
142MAPK110.27825167

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.05933473
2DNA replication_Homo sapiens_hsa030303.40395420
3Proteasome_Homo sapiens_hsa030503.09364700
4RNA polymerase_Homo sapiens_hsa030202.96644593
5Homologous recombination_Homo sapiens_hsa034402.75195642
6Protein export_Homo sapiens_hsa030602.42345499
7Pyrimidine metabolism_Homo sapiens_hsa002402.40350049
8Mismatch repair_Homo sapiens_hsa034302.27235812
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.27187841
10Base excision repair_Homo sapiens_hsa034102.25362279
11Fanconi anemia pathway_Homo sapiens_hsa034602.13589089
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.12180174
13Nucleotide excision repair_Homo sapiens_hsa034202.08103522
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06837706
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95978372
16Folate biosynthesis_Homo sapiens_hsa007901.95805958
17Basal transcription factors_Homo sapiens_hsa030221.92597862
18Spliceosome_Homo sapiens_hsa030401.89809243
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82249906
20Oxidative phosphorylation_Homo sapiens_hsa001901.75203316
21One carbon pool by folate_Homo sapiens_hsa006701.71967693
22Nitrogen metabolism_Homo sapiens_hsa009101.68193563
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58219178
24Cardiac muscle contraction_Homo sapiens_hsa042601.55699598
25Sulfur relay system_Homo sapiens_hsa041221.54066747
26Non-homologous end-joining_Homo sapiens_hsa034501.48321531
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47197099
28Parkinsons disease_Homo sapiens_hsa050121.46719228
29Purine metabolism_Homo sapiens_hsa002301.43165504
30Sulfur metabolism_Homo sapiens_hsa009201.42351980
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37855488
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32542844
33Butanoate metabolism_Homo sapiens_hsa006501.29665359
34RNA degradation_Homo sapiens_hsa030181.25984777
35Arachidonic acid metabolism_Homo sapiens_hsa005901.24364658
36Cell cycle_Homo sapiens_hsa041101.21305188
37Huntingtons disease_Homo sapiens_hsa050161.19758684
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19504928
39Glutathione metabolism_Homo sapiens_hsa004801.19447296
40Fatty acid elongation_Homo sapiens_hsa000621.15488434
41RNA transport_Homo sapiens_hsa030131.13601257
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13486517
43Chemical carcinogenesis_Homo sapiens_hsa052041.07939387
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07372173
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.06266811
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.05607286
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04877874
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.01979888
49Retinol metabolism_Homo sapiens_hsa008301.00991567
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00211894
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96102468
52Vitamin B6 metabolism_Homo sapiens_hsa007500.96082217
53Peroxisome_Homo sapiens_hsa041460.94926295
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94142810
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93348795
56Collecting duct acid secretion_Homo sapiens_hsa049660.91845359
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91664658
58Propanoate metabolism_Homo sapiens_hsa006400.90081281
59Histidine metabolism_Homo sapiens_hsa003400.89719079
60Steroid biosynthesis_Homo sapiens_hsa001000.88496169
61p53 signaling pathway_Homo sapiens_hsa041150.87103013
62Vitamin digestion and absorption_Homo sapiens_hsa049770.85384664
63Linoleic acid metabolism_Homo sapiens_hsa005910.84914398
64Alzheimers disease_Homo sapiens_hsa050100.84249020
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83064461
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.82877619
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82626303
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.80039232
69Metabolic pathways_Homo sapiens_hsa011000.79589228
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79563030
71Systemic lupus erythematosus_Homo sapiens_hsa053220.79370884
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78483498
73Allograft rejection_Homo sapiens_hsa053300.78326805
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76854646
75Other glycan degradation_Homo sapiens_hsa005110.74232545
76Herpes simplex infection_Homo sapiens_hsa051680.73427413
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73257125
78Asthma_Homo sapiens_hsa053100.70389188
79beta-Alanine metabolism_Homo sapiens_hsa004100.70257664
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69660268
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.68136994
82Graft-versus-host disease_Homo sapiens_hsa053320.66741028
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66569964
84Primary immunodeficiency_Homo sapiens_hsa053400.65196844
85Sphingolipid metabolism_Homo sapiens_hsa006000.64995561
86Arginine and proline metabolism_Homo sapiens_hsa003300.63489222
87Regulation of autophagy_Homo sapiens_hsa041400.63004970
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59232007
89Ether lipid metabolism_Homo sapiens_hsa005650.56755635
90Measles_Homo sapiens_hsa051620.56514352
91Hematopoietic cell lineage_Homo sapiens_hsa046400.55341591
92Caffeine metabolism_Homo sapiens_hsa002320.55078832
93Complement and coagulation cascades_Homo sapiens_hsa046100.54922560
94Rheumatoid arthritis_Homo sapiens_hsa053230.50716128
95Malaria_Homo sapiens_hsa051440.48214417
96Autoimmune thyroid disease_Homo sapiens_hsa053200.47893439
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47888746
98Pyruvate metabolism_Homo sapiens_hsa006200.46898643
99Epstein-Barr virus infection_Homo sapiens_hsa051690.46384525
100Olfactory transduction_Homo sapiens_hsa047400.46151825
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.45521016
102Nicotine addiction_Homo sapiens_hsa050330.45159076
103Mineral absorption_Homo sapiens_hsa049780.44970278
104Staphylococcus aureus infection_Homo sapiens_hsa051500.44508524
105Selenocompound metabolism_Homo sapiens_hsa004500.44179432
106N-Glycan biosynthesis_Homo sapiens_hsa005100.43399436
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42558048
108Pentose phosphate pathway_Homo sapiens_hsa000300.41939413
109Type I diabetes mellitus_Homo sapiens_hsa049400.37253049
110Taste transduction_Homo sapiens_hsa047420.34419479
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33975548
112Fat digestion and absorption_Homo sapiens_hsa049750.33705486
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.32767179
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32721761
115Tryptophan metabolism_Homo sapiens_hsa003800.32230373
116Phototransduction_Homo sapiens_hsa047440.31944454
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.30094740
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29604372
119Antigen processing and presentation_Homo sapiens_hsa046120.28729800
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28160971
121ABC transporters_Homo sapiens_hsa020100.26564391

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