PSME1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.42242130
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.42242130
3antigen processing and presentation of endogenous antigen (GO:0019883)5.98608950
4ribosomal small subunit assembly (GO:0000028)5.77361462
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80038076
6viral transcription (GO:0019083)4.56621407
7translational termination (GO:0006415)4.36168979
8positive regulation of gamma-delta T cell activation (GO:0046645)4.20505046
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.11999902
10negative regulation of cell killing (GO:0031342)4.11999902
11antigen processing and presentation via MHC class Ib (GO:0002475)3.96158698
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83142170
13translational elongation (GO:0006414)3.82007289
14cytidine deamination (GO:0009972)3.80747967
15cytidine metabolic process (GO:0046087)3.80747967
16cytidine catabolic process (GO:0006216)3.80747967
17response to interferon-beta (GO:0035456)3.80299799
18ribosomal small subunit biogenesis (GO:0042274)3.77724605
19DNA deamination (GO:0045006)3.76495853
20protein targeting to ER (GO:0045047)3.71662243
21cotranslational protein targeting to membrane (GO:0006613)3.70857108
22response to type I interferon (GO:0034340)3.66879104
23cellular response to type I interferon (GO:0071357)3.66074725
24type I interferon signaling pathway (GO:0060337)3.66074725
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62783419
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.58150712
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.55504932
28Arp2/3 complex-mediated actin nucleation (GO:0034314)3.54698337
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.51935265
30protein localization to endoplasmic reticulum (GO:0070972)3.51730098
31cellular response to interleukin-15 (GO:0071350)3.50780179
32immunoglobulin mediated immune response (GO:0016064)3.43901448
33viral life cycle (GO:0019058)3.41259251
34cellular response to interferon-beta (GO:0035458)3.32742770
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32286243
36maturation of SSU-rRNA (GO:0030490)3.32063005
37NIK/NF-kappaB signaling (GO:0038061)3.31237105
38regulation of gamma-delta T cell differentiation (GO:0045586)3.26134552
39pyrimidine ribonucleoside catabolic process (GO:0046133)3.25956068
40defense response to protozoan (GO:0042832)3.20748628
41cellular protein complex disassembly (GO:0043624)3.19878148
42positive regulation of B cell differentiation (GO:0045579)3.17775754
43regulation of regulatory T cell differentiation (GO:0045589)3.14830630
44B cell mediated immunity (GO:0019724)3.14370756
45cellular response to zinc ion (GO:0071294)3.14266501
46detection of bacterium (GO:0016045)3.14191917
47translational initiation (GO:0006413)3.10233794
48response to protozoan (GO:0001562)3.08088092
49myeloid dendritic cell activation (GO:0001773)3.04890636
50regulation of gamma-delta T cell activation (GO:0046643)3.04655872
51regulation of interleukin-12 biosynthetic process (GO:0045075)3.04530018
52response to interferon-alpha (GO:0035455)3.02023005
53positive T cell selection (GO:0043368)3.00712119
54positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97244468
55regulation of B cell receptor signaling pathway (GO:0050855)2.96903872
56regulation of T cell tolerance induction (GO:0002664)2.96659142
57detection of other organism (GO:0098543)2.96294578
58regulation of B cell differentiation (GO:0045577)2.94525419
59thymic T cell selection (GO:0045061)2.94261650
60positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.94249901
61interferon-gamma-mediated signaling pathway (GO:0060333)2.93013988
62negative thymic T cell selection (GO:0045060)2.92447134
63regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89238200
64regulation of natural killer cell mediated immunity (GO:0002715)2.89238200
65negative T cell selection (GO:0043383)2.86430829
66regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84597901
67regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84014896
68regulation of leukocyte mediated cytotoxicity (GO:0001910)2.82963328
69T cell selection (GO:0045058)2.82315566
70regulation of response to interferon-gamma (GO:0060330)2.82303498
71positive regulation of interferon-alpha production (GO:0032727)2.82104631
72positive regulation of antigen processing and presentation (GO:0002579)2.80293059
73myeloid dendritic cell differentiation (GO:0043011)2.80034252
74protein complex disassembly (GO:0043241)2.79543918
75modulation by symbiont of host defense response (GO:0052031)2.79285497
76modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79285497
77modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79285497
78positive regulation by organism of defense response of other organism involved in symbiotic interact2.79285497
79modulation by symbiont of host immune response (GO:0052553)2.79285497
80positive regulation by symbiont of host defense response (GO:0052509)2.79285497
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79145269
82T cell migration (GO:0072678)2.77589178
83negative regulation of interleukin-12 production (GO:0032695)2.74815086
84telomere maintenance via semi-conservative replication (GO:0032201)2.74446265
85ribosomal large subunit biogenesis (GO:0042273)2.71645847
86positive regulation of cell killing (GO:0031343)2.70936732
87regulation of tolerance induction (GO:0002643)2.69313378
88regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.69059385
89regulation of interferon-alpha production (GO:0032647)2.68307035
90antigen receptor-mediated signaling pathway (GO:0050851)2.66908456
91T cell costimulation (GO:0031295)2.66623152
92leukocyte aggregation (GO:0070486)2.66609443
93cellular response to interferon-gamma (GO:0071346)2.65967523
94negative regulation of lymphocyte mediated immunity (GO:0002707)2.64320762
95positive regulation of granulocyte differentiation (GO:0030854)2.64108320
96lymphocyte costimulation (GO:0031294)2.63940346
97regulation of cell killing (GO:0031341)2.61825410
98T cell receptor signaling pathway (GO:0050852)2.60982914
99macromolecular complex disassembly (GO:0032984)2.60957244
100negative regulation of phagocytosis (GO:0050765)2.60196484
101mast cell activation (GO:0045576)2.59101550
102negative regulation of leukocyte mediated immunity (GO:0002704)2.58605705
103positive regulation of natural killer cell differentiation (GO:0032825)2.58309809
104negative regulation of T cell mediated immunity (GO:0002710)2.58247860
105negative regulation of innate immune response (GO:0045824)2.57562028
106response to peptidoglycan (GO:0032494)2.57554175
107regulation of T cell receptor signaling pathway (GO:0050856)2.56349821
108DNA strand elongation involved in DNA replication (GO:0006271)2.56159657
109response to interferon-gamma (GO:0034341)2.56139068
110interferon-gamma production (GO:0032609)2.55106457
111regulation of RIG-I signaling pathway (GO:0039535)2.54373152
112regulation of alpha-beta T cell proliferation (GO:0046640)2.54287772
113regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.53225442
114negative regulation of viral genome replication (GO:0045071)2.51856976
115regulation of necroptotic process (GO:0060544)2.51776122
116positive regulation of tolerance induction (GO:0002645)2.50944999
117lymphocyte migration (GO:0072676)2.50858898
118lymphocyte chemotaxis (GO:0048247)2.50647523
119neutrophil activation involved in immune response (GO:0002283)2.50622741
120positive thymic T cell selection (GO:0045059)2.50364355
121response to interleukin-15 (GO:0070672)2.50226178
122neutrophil activation (GO:0042119)2.50147217
123actin nucleation (GO:0045010)2.48928608
124nuclear-transcribed mRNA catabolic process (GO:0000956)2.48884357
125cellular response to exogenous dsRNA (GO:0071360)2.48303508
126regulation of interferon-beta biosynthetic process (GO:0045357)2.47407579
127DNA strand elongation (GO:0022616)2.46946479
128positive regulation of defense response to virus by host (GO:0002230)2.46920120
129positive regulation of T cell mediated immunity (GO:0002711)2.46918793
130regulation of antigen processing and presentation (GO:0002577)2.46205744
131sequestering of actin monomers (GO:0042989)2.45922673
132T cell homeostasis (GO:0043029)2.45858796
133regulation of T cell mediated cytotoxicity (GO:0001914)2.45715859
134positive regulation of T cell mediated cytotoxicity (GO:0001916)2.45605037
135telomere maintenance via recombination (GO:0000722)2.43755894
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42103821
137protein targeting to membrane (GO:0006612)2.40698546
138* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.40165513
139T cell apoptotic process (GO:0070231)2.39840405
140mRNA catabolic process (GO:0006402)2.39334487
141formation of translation preinitiation complex (GO:0001731)2.38562178
142respiratory burst (GO:0045730)2.36918988
143B cell receptor signaling pathway (GO:0050853)2.36862268
144lymph node development (GO:0048535)2.35589202
145positive regulation of humoral immune response (GO:0002922)2.35172787
146natural killer cell activation (GO:0030101)2.34958070
147* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.34763945
148mature B cell differentiation involved in immune response (GO:0002313)2.34350028
149dendritic cell differentiation (GO:0097028)2.33803974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.71700279
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.67186236
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.58957952
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.12981364
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03372008
6* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.90874238
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.66894593
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65641027
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.62352281
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62253961
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50905509
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43497292
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.42710244
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.40532903
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.36909384
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.32475961
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.25485893
18MYC_22102868_ChIP-Seq_BL_Human2.23190640
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20336412
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.14781077
21SCL_19346495_ChIP-Seq_HPC-7_Human2.11596204
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08733694
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06432865
24VDR_21846776_ChIP-Seq_THP-1_Human2.02996628
25SPI1_23547873_ChIP-Seq_NB4_Human2.02465131
26MYB_26560356_Chip-Seq_TH2_Human1.90695127
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.89022726
28MAF_26560356_Chip-Seq_TH1_Human1.88249179
29GATA1_22025678_ChIP-Seq_K562_Human1.86975235
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.84711637
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.82579404
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81673442
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77361180
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.74939769
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73393502
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71957525
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69824929
38VDR_23849224_ChIP-Seq_CD4+_Human1.67788348
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67457294
40MYB_26560356_Chip-Seq_TH1_Human1.67209686
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66063864
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64165720
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61908422
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59534459
45VDR_24763502_ChIP-Seq_THP-1_Human1.58242090
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57543513
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.56558635
48UTX_26944678_Chip-Seq_JUKART_Human1.54373600
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54160402
50GATA3_26560356_Chip-Seq_TH2_Human1.49806067
51FOXP3_21729870_ChIP-Seq_TREG_Human1.49361367
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.49025560
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46337569
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45885771
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44689029
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44685063
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42821462
58* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42067959
59* XRN2_22483619_ChIP-Seq_HELA_Human1.41485881
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41078435
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38585046
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37855487
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37368873
64CIITA_25753668_ChIP-Seq_RAJI_Human1.35008556
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34890844
66BCL6_27268052_Chip-Seq_Bcells_Human1.32061059
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31892610
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31447027
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30595904
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30227201
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29385203
72* MAF_26560356_Chip-Seq_TH2_Human1.28606488
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28237537
74RUNX_20019798_ChIP-Seq_JUKART_Human1.25530753
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.24534939
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24151797
77DCP1A_22483619_ChIP-Seq_HELA_Human1.23507615
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23098218
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21342913
80E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19593128
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18792051
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18077208
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16789726
84TCF7_22412390_ChIP-Seq_EML_Mouse1.15292370
85NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15285087
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14164937
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13898849
88ELK1_19687146_ChIP-ChIP_HELA_Human1.13072360
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12873207
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.10155039
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09401973
92* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09038105
93* GABP_19822575_ChIP-Seq_HepG2_Human1.07860345
94BCOR_27268052_Chip-Seq_Bcells_Human1.07854954
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06854671
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05781840
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05641259
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05047766
99GATA3_27048872_Chip-Seq_THYMUS_Human1.05030717
100PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04783081
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03603568
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.03346882
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02764724
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01852083
105P300_27268052_Chip-Seq_Bcells_Human1.01660500
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00891096
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98835334
108CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98691904
109TTF2_22483619_ChIP-Seq_HELA_Human0.98667867
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97707528
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97298859
112PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96710965
113SPI1_23127762_ChIP-Seq_K562_Human0.95970963
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95570893
115PU_27001747_Chip-Seq_BMDM_Mouse0.93558657
116RXR_22158963_ChIP-Seq_LIVER_Mouse0.90485864
117STAT1_20625510_ChIP-Seq_HELA_Human0.90336227
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89800930
119CTCF_26484167_Chip-Seq_Bcells_Mouse0.88701388
120SPI1_20517297_ChIP-Seq_HL60_Human0.85214528
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84681460
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82380174
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82171320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.45293905
2MP0000685_abnormal_immune_system3.36935979
3MP0009785_altered_susceptibility_to3.25965168
4MP0005671_abnormal_response_to3.20733411
5MP0003763_abnormal_thymus_physiology2.88154652
6MP0002396_abnormal_hematopoietic_system2.73041863
7MP0003436_decreased_susceptibility_to2.69653444
8MP0001800_abnormal_humoral_immune2.69363312
9MP0005025_abnormal_response_to2.68830475
10MP0005387_immune_system_phenotype2.60060671
11MP0001790_abnormal_immune_system2.60060671
12MP0003724_increased_susceptibility_to2.58242771
13MP0002148_abnormal_hypersensitivity_rea2.56456829
14MP0005000_abnormal_immune_tolerance2.55454173
15MP0002452_abnormal_antigen_presenting2.42594439
16MP0002723_abnormal_immune_serum2.39696726
17MP0002420_abnormal_adaptive_immunity2.33192046
18MP0001819_abnormal_immune_cell2.33029016
19MP0002398_abnormal_bone_marrow2.20979191
20MP0001853_heart_inflammation2.20327636
21MP0002419_abnormal_innate_immunity2.15458916
22MP0009333_abnormal_splenocyte_physiolog2.15324619
23* MP0002166_altered_tumor_susceptibility2.10751453
24MP0010155_abnormal_intestine_physiology2.03389835
25MP0000716_abnormal_immune_system2.01597686
26MP0002405_respiratory_system_inflammati1.93810516
27MP0005464_abnormal_platelet_physiology1.92385443
28MP0001873_stomach_inflammation1.86450427
29MP0000689_abnormal_spleen_morphology1.85595701
30MP0005397_hematopoietic_system_phenotyp1.83983020
31MP0001545_abnormal_hematopoietic_system1.83983020
32MP0002722_abnormal_immune_system1.82072211
33* MP0002006_tumorigenesis1.77979033
34MP0002429_abnormal_blood_cell1.77093679
35MP0006082_CNS_inflammation1.75405345
36MP0004808_abnormal_hematopoietic_stem1.73687822
37MP0001845_abnormal_inflammatory_respons1.70637920
38MP0003693_abnormal_embryo_hatching1.65951978
39MP0000490_abnormal_crypts_of1.60212631
40MP0004510_myositis1.59507737
41MP0002138_abnormal_hepatobiliary_system1.53879567
42MP0004947_skin_inflammation1.53199129
43MP0008469_abnormal_protein_level1.52842849
44MP0003866_abnormal_defecation1.52244999
45MP0002139_abnormal_hepatobiliary_system1.48067235
46MP0000703_abnormal_thymus_morphology1.47257519
47MP0003303_peritoneal_inflammation1.37066911
48MP0000858_altered_metastatic_potential1.34413441
49MP0005360_urolithiasis1.32657230
50MP0003300_gastrointestinal_ulcer1.30816425
51MP0000465_gastrointestinal_hemorrhage1.28617014
52MP0005174_abnormal_tail_pigmentation1.23634028
53MP0003186_abnormal_redox_activity1.22781379
54MP0003191_abnormal_cellular_cholesterol1.20086498
55MP0003075_altered_response_to1.18681106
56MP0005075_abnormal_melanosome_morpholog1.16404993
57MP0001533_abnormal_skeleton_physiology1.16370715
58MP0005166_decreased_susceptibility_to1.15976069
59MP0009764_decreased_sensitivity_to1.15327468
60MP0002019_abnormal_tumor_incidence1.13590490
61MP0005310_abnormal_salivary_gland1.10229532
62MP0010094_abnormal_chromosome_stability1.06154053
63MP0002132_abnormal_respiratory_system1.06116473
64MP0004957_abnormal_blastocyst_morpholog1.03364570
65MP0003448_altered_tumor_morphology1.03316518
66MP0003077_abnormal_cell_cycle1.02958282
67MP0000343_altered_response_to1.01927839
68MP0008057_abnormal_DNA_replication1.01809198
69MP0008007_abnormal_cellular_replicative1.01109924
70MP0003252_abnormal_bile_duct1.00139150
71MP0002933_joint_inflammation0.99410172
72MP0009278_abnormal_bone_marrow0.98535170
73MP0003183_abnormal_peptide_metabolism0.97583770
74MP0008875_abnormal_xenobiotic_pharmacok0.96968576
75MP0005451_abnormal_body_composition0.96925881
76MP0002277_abnormal_respiratory_mucosa0.95958179
77MP0009379_abnormal_foot_pigmentation0.94657293
78MP0009763_increased_sensitivity_to0.94286481
79MP0010352_gastrointestinal_tract_polyps0.93781704
80MP0006054_spinal_hemorrhage0.90403472
81MP0008058_abnormal_DNA_repair0.88378605
82MP0005085_abnormal_gallbladder_physiolo0.88243523
83MP0009840_abnormal_foam_cell0.86494429
84MP0002163_abnormal_gland_morphology0.82103380
85MP0001666_abnormal_nutrient_absorption0.81480924
86MP0004782_abnormal_surfactant_physiolog0.81230113
87MP0002095_abnormal_skin_pigmentation0.79352578
88MP0002693_abnormal_pancreas_physiology0.78612282
89MP0001348_abnormal_lacrimal_gland0.78453912
90MP0000609_abnormal_liver_physiology0.76754159
91MP0000313_abnormal_cell_death0.75825057
92MP0004381_abnormal_hair_follicle0.75801472
93MP0002254_reproductive_system_inflammat0.75332780
94MP0003828_pulmonary_edema0.74675746
95MP0001851_eye_inflammation0.74483857
96MP0005319_abnormal_enzyme/_coenzyme0.73512277
97MP0005058_abnormal_lysosome_morphology0.72910916
98MP0000598_abnormal_liver_morphology0.71529985
99MP0005084_abnormal_gallbladder_morpholo0.70769012
100MP0003656_abnormal_erythrocyte_physiolo0.70024217
101MP0002876_abnormal_thyroid_physiology0.69035807
102MP0002998_abnormal_bone_remodeling0.67661203
103MP0001663_abnormal_digestive_system0.67396664
104MP0000372_irregular_coat_pigmentation0.67362665
105MP0010307_abnormal_tumor_latency0.67034869
106MP0001764_abnormal_homeostasis0.66354989
107MP0005165_increased_susceptibility_to0.64862041
108MP0000249_abnormal_blood_vessel0.64654527
109MP0009643_abnormal_urine_homeostasis0.64522143
110MP0005584_abnormal_enzyme/coenzyme_acti0.64424649
111MP0008873_increased_physiological_sensi0.64246514
112MP0003786_premature_aging0.63437431
113MP0005636_abnormal_mineral_homeostasis0.63121825
114MP0000604_amyloidosis0.63017128
115MP0005390_skeleton_phenotype0.62293344
116MP0002136_abnormal_kidney_physiology0.61952511
117MP0000477_abnormal_intestine_morphology0.61618126
118MP0006036_abnormal_mitochondrial_physio0.61560866
119MP0005164_abnormal_response_to0.61207236
120MP0003806_abnormal_nucleotide_metabolis0.60788675
121MP0009765_abnormal_xenobiotic_induced0.59578215
122MP0003172_abnormal_lysosome_physiology0.58580252
123MP0005023_abnormal_wound_healing0.57310260
124MP0003111_abnormal_nucleus_morphology0.57186797
125MP0003943_abnormal_hepatobiliary_system0.57142133
126MP0005365_abnormal_bile_salt0.56105036

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.97416391
2Chronic otitis media (HP:0000389)4.51377334
3Thrombocytosis (HP:0001894)4.36100287
4Recurrent abscess formation (HP:0002722)4.08530802
5Myositis (HP:0100614)4.07680992
6Eczematoid dermatitis (HP:0000976)4.00921245
7Recurrent bronchitis (HP:0002837)3.94081917
8IgM deficiency (HP:0002850)3.92716110
9Abnormality of cells of the erythroid lineage (HP:0012130)3.75243916
10Recurrent bacterial skin infections (HP:0005406)3.74712281
11Abnormal number of erythroid precursors (HP:0012131)3.61636215
12Recurrent viral infections (HP:0004429)3.55548720
13Recurrent fungal infections (HP:0002841)3.53873778
14Nasal polyposis (HP:0100582)3.41559481
15Reticulocytopenia (HP:0001896)3.38772696
16Abnormality of the nasal mucosa (HP:0000433)3.32503937
17Abnormality of T cell physiology (HP:0011840)3.32273275
18Abnormality of T cells (HP:0002843)3.30667490
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.17011180
20Autoimmune thrombocytopenia (HP:0001973)3.15709550
21Petechiae (HP:0000967)3.05748949
22Abnormality of T cell number (HP:0011839)3.05246765
23Panhypogammaglobulinemia (HP:0003139)2.95354561
24T lymphocytopenia (HP:0005403)2.93832784
25Pustule (HP:0200039)2.90905417
26Recurrent cutaneous fungal infections (HP:0011370)2.89955534
27Chronic mucocutaneous candidiasis (HP:0002728)2.89955534
28Recurrent skin infections (HP:0001581)2.89760479
29Mediastinal lymphadenopathy (HP:0100721)2.87937913
30Vasculitis (HP:0002633)2.84905883
31IgG deficiency (HP:0004315)2.83471455
32Orchitis (HP:0100796)2.81295165
33Meningitis (HP:0001287)2.81044884
34Interstitial pulmonary disease (HP:0006530)2.74019989
35Aplastic anemia (HP:0001915)2.72453908
36Agammaglobulinemia (HP:0004432)2.71586848
37Recurrent gram-negative bacterial infections (HP:0005420)2.67787622
38Severe combined immunodeficiency (HP:0004430)2.67764748
39Autoimmune hemolytic anemia (HP:0001890)2.63342319
40Abnormality of cells of the lymphoid lineage (HP:0012140)2.62063656
41Lymphopenia (HP:0001888)2.59949879
42Increased IgM level (HP:0003496)2.57993164
43Combined immunodeficiency (HP:0005387)2.57971526
44Pallor (HP:0000980)2.57327326
45Abnormality of macrophages (HP:0004311)2.57034377
46Spontaneous hematomas (HP:0007420)2.56476152
47Hypergammaglobulinemia (HP:0010702)2.54627929
48Inflammation of the large intestine (HP:0002037)2.51004237
49Abnormality of B cell number (HP:0010975)2.50396771
50B lymphocytopenia (HP:0010976)2.50396771
51Gastrointestinal inflammation (HP:0004386)2.50008702
52Retrobulbar optic neuritis (HP:0100654)2.49559314
53Optic neuritis (HP:0100653)2.49559314
54Chronic sinusitis (HP:0011109)2.44916787
55Cellulitis (HP:0100658)2.43274148
56Epistaxis (HP:0000421)2.41362849
57Prolonged bleeding time (HP:0003010)2.38141233
58Acute hepatic failure (HP:0006554)2.34632826
59Keratoconjunctivitis sicca (HP:0001097)2.34537853
60Obstructive lung disease (HP:0006536)2.32489714
61Chronic obstructive pulmonary disease (HP:0006510)2.32489714
62Systemic lupus erythematosus (HP:0002725)2.32281239
63Lymphoma (HP:0002665)2.31702550
64Granulocytopenia (HP:0001913)2.31354990
65Periodontitis (HP:0000704)2.30800755
66Hypoproteinemia (HP:0003075)2.29874816
67Leukocytosis (HP:0001974)2.29449272
68Gingival bleeding (HP:0000225)2.28388331
69Poikiloderma (HP:0001029)2.27589055
70Colitis (HP:0002583)2.27474103
71Increased IgE level (HP:0003212)2.27302950
72Keratoconjunctivitis (HP:0001096)2.27131054
73Thyroiditis (HP:0100646)2.26835750
74Increased intramyocellular lipid droplets (HP:0012240)2.26815917
75Abnormality of eosinophils (HP:0001879)2.25888771
76Mitochondrial inheritance (HP:0001427)2.25886163
77Encephalitis (HP:0002383)2.25448921
78Purpura (HP:0000979)2.24317714
79Bronchitis (HP:0012387)2.23931271
80Hemoptysis (HP:0002105)2.23718341
81Eosinophilia (HP:0001880)2.22677406
82Macrocytic anemia (HP:0001972)2.22507161
83Microcytic anemia (HP:0001935)2.22274715
84Abnormality of the pleura (HP:0002103)2.22216674
85Chronic diarrhea (HP:0002028)2.21687160
86Gastrointestinal stroma tumor (HP:0100723)2.20678288
87Gangrene (HP:0100758)2.19568551
88Hepatocellular necrosis (HP:0001404)2.17889507
89Reduced antithrombin III activity (HP:0001976)2.16631027
90Hepatic necrosis (HP:0002605)2.16330171
91Basal ganglia calcification (HP:0002135)2.15600832
92Increased muscle lipid content (HP:0009058)2.15445574
93Stomatitis (HP:0010280)2.11939555
94IgA deficiency (HP:0002720)2.11565259
95Anorexia (HP:0002039)2.10784489
96Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09554317
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09554317
98Gastrointestinal infarctions (HP:0005244)2.08340975
99Hypoplasia of the thymus (HP:0000778)2.07222817
100Urticaria (HP:0001025)2.07145664
101Increased serum ferritin (HP:0003281)2.05893059
102Pulmonary infiltrates (HP:0002113)2.05745213
103Arterial thrombosis (HP:0004420)2.05555214
104Joint swelling (HP:0001386)2.03710557
105Abnormality of the prostate (HP:0008775)2.02221954
106Pulmonary embolism (HP:0002204)2.01839379
107Skin ulcer (HP:0200042)2.01665342
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01333024
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99791737
110Abnormal platelet function (HP:0011869)1.99153594
111Impaired platelet aggregation (HP:0003540)1.99153594
112Abnormality of iron homeostasis (HP:0011031)1.98699887
113Verrucae (HP:0200043)1.97991883
114Papilloma (HP:0012740)1.97991883
115Neutropenia (HP:0001875)1.97444573
116Dicarboxylic aciduria (HP:0003215)1.96699274
117Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96699274
118Skin rash (HP:0000988)1.96151658
119Abnormality of glycosphingolipid metabolism (HP:0004343)1.95779873
120Abnormality of glycolipid metabolism (HP:0010969)1.95779873
121Abnormality of liposaccharide metabolism (HP:0010968)1.95779873
122Gingivitis (HP:0000230)1.95434183
123Hepatosplenomegaly (HP:0001433)1.94323428
124Exertional dyspnea (HP:0002875)1.93295107
125Increased CSF lactate (HP:0002490)1.93010757
126Vacuolated lymphocytes (HP:0001922)1.92274238
127Pulmonary fibrosis (HP:0002206)1.90283306
128Amaurosis fugax (HP:0100576)1.89128187
129Chest pain (HP:0100749)1.88031562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.99389619
2VRK23.18302148
3NME23.06344142
4KIT2.69010315
5TYK22.60558139
6JAK32.58022766
7TBK12.56872709
8RIPK42.55529825
9TXK2.53468816
10ZAP702.37578861
11IKBKE2.35751375
12MAP3K142.35693476
13BLK2.29737924
14FLT32.22569090
15IRAK42.12268535
16TEC2.10220618
17PIM22.07707159
18BTK2.02062524
19KDR1.99910530
20IKBKB1.70357816
21FGFR41.67045626
22ERN11.65626427
23SYK1.61557462
24RPS6KA41.52916829
25TNK21.52840384
26TGFBR11.50403396
27CSF1R1.49226986
28LRRK21.46986569
29ACVR1B1.43921777
30MAP2K31.41269362
31JAK11.32834332
32BMPR21.32607526
33NLK1.29548195
34PKN21.29440167
35IRAK31.28470564
36STK161.24901032
37ITK1.24608747
38TAOK31.22642385
39EIF2AK11.19640436
40GRK61.17749364
41STK101.15881604
42LCK1.15061721
43TGFBR21.14976889
44EEF2K1.14827139
45PIM11.11036432
46CHUK1.05578487
47TESK21.05202876
48DAPK11.05010465
49LYN1.03835304
50BCKDK1.02851595
51MST40.99810748
52MAP3K120.99453366
53MAP3K100.97819248
54NEK90.97270816
55RPS6KB20.96804301
56PRKCQ0.95471148
57WEE10.94869428
58SMG10.92414045
59NUAK10.88624964
60CSK0.88222659
61MAP3K110.86985194
62FGFR30.86951643
63VRK10.85499680
64SCYL20.83224565
65MYLK0.80551308
66GRK70.80428469
67HCK0.79534370
68EIF2AK30.79399458
69MATK0.77258136
70STK40.75520895
71CDK40.75354571
72STK240.71113653
73JAK20.66714586
74PASK0.65418629
75TAOK20.64526327
76HIPK20.62764670
77DYRK30.61876743
78MAP3K10.60224053
79ATR0.60039096
80CDC70.59985396
81MAP3K130.59852843
82MAP2K20.59334604
83NEK20.58061383
84MAPKAPK30.57821450
85ILK0.57665852
86MAP3K30.56667374
87MAPK110.55389406
88TIE10.55207715
89EPHB10.55202069
90MAP2K60.55099812
91BUB10.54434080
92SIK30.53495515
93EIF2AK20.51560735
94TAF10.51436497
95LIMK10.51268238
96TRIB30.50043397
97TLK10.49512142
98PDK10.49104662
99AURKB0.48644817
100RPS6KA60.47709474
101CDK70.46522739
102PRPF4B0.46397337
103PAK40.45635234
104MAP4K20.45291896
105PRKG20.44587630
106ADRBK20.44518471
107MAP3K50.43668106
108TSSK60.42540532
109MARK30.41881881
110TESK10.41841205
111CLK10.40083336
112DAPK30.39909771
113MAPKAPK20.39806588
114FES0.39164561
115MAP3K80.39075862
116BRSK20.38708609
117TAOK10.37798196
118PIK3CG0.37760383
119MAPK40.37146579
120RPS6KA50.36913123
121GRK50.36805665
122PRKCD0.36721558
123CDK60.36517839
124EPHA30.35833540
125PIK3CA0.34082358
126RPS6KC10.33829892
127CDK190.33481096
128FYN0.33007226
129IRAK10.32063395
130FGR0.31340069
131ZAK0.30699772

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.79193066
2Primary immunodeficiency_Homo sapiens_hsa053403.20173172
3DNA replication_Homo sapiens_hsa030303.07236785
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.63982919
5Mismatch repair_Homo sapiens_hsa034302.24760257
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.20800741
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.20121664
8Leishmaniasis_Homo sapiens_hsa051402.17388011
9Allograft rejection_Homo sapiens_hsa053302.14157853
10Measles_Homo sapiens_hsa051622.10047900
11* Proteasome_Homo sapiens_hsa030502.04919918
12* Antigen processing and presentation_Homo sapiens_hsa046121.99920127
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98686691
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89747150
15Herpes simplex infection_Homo sapiens_hsa051681.86069958
16Base excision repair_Homo sapiens_hsa034101.83847130
17Graft-versus-host disease_Homo sapiens_hsa053321.73380047
18Legionellosis_Homo sapiens_hsa051341.63795608
19Rheumatoid arthritis_Homo sapiens_hsa053231.60396854
20Homologous recombination_Homo sapiens_hsa034401.59780773
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55812701
22Hematopoietic cell lineage_Homo sapiens_hsa046401.53250340
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43035521
24Pyrimidine metabolism_Homo sapiens_hsa002401.42851439
25B cell receptor signaling pathway_Homo sapiens_hsa046621.40728675
26Oxidative phosphorylation_Homo sapiens_hsa001901.37601338
27Osteoclast differentiation_Homo sapiens_hsa043801.34462241
28Influenza A_Homo sapiens_hsa051641.32793975
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31032206
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.30992475
31Spliceosome_Homo sapiens_hsa030401.28772941
32Staphylococcus aureus infection_Homo sapiens_hsa051501.27983486
33Pertussis_Homo sapiens_hsa051331.27768382
34Nucleotide excision repair_Homo sapiens_hsa034201.26116623
35Asthma_Homo sapiens_hsa053101.18025368
36RNA polymerase_Homo sapiens_hsa030201.15254858
37Toxoplasmosis_Homo sapiens_hsa051451.14709641
38T cell receptor signaling pathway_Homo sapiens_hsa046601.12556294
39Non-homologous end-joining_Homo sapiens_hsa034501.09808685
40Apoptosis_Homo sapiens_hsa042101.08170251
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07088467
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05968607
43One carbon pool by folate_Homo sapiens_hsa006701.05109012
44Shigellosis_Homo sapiens_hsa051311.04638129
45Viral myocarditis_Homo sapiens_hsa054161.04238762
46Sulfur relay system_Homo sapiens_hsa041221.03176871
47Caffeine metabolism_Homo sapiens_hsa002321.02834900
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00628551
49Autoimmune thyroid disease_Homo sapiens_hsa053201.00168147
50Malaria_Homo sapiens_hsa051440.98347584
51Pentose phosphate pathway_Homo sapiens_hsa000300.95179089
52TNF signaling pathway_Homo sapiens_hsa046680.94802394
53Acute myeloid leukemia_Homo sapiens_hsa052210.94134041
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92553248
55Epstein-Barr virus infection_Homo sapiens_hsa051690.91941479
56Hepatitis B_Homo sapiens_hsa051610.89959606
57Folate biosynthesis_Homo sapiens_hsa007900.87687975
58Type I diabetes mellitus_Homo sapiens_hsa049400.86575101
59Tuberculosis_Homo sapiens_hsa051520.85114084
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82919614
61p53 signaling pathway_Homo sapiens_hsa041150.82027702
62Sulfur metabolism_Homo sapiens_hsa009200.81824812
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.79425978
64Other glycan degradation_Homo sapiens_hsa005110.79374160
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77959641
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77467569
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74958209
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74606348
69RNA degradation_Homo sapiens_hsa030180.70031669
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69875753
71Protein export_Homo sapiens_hsa030600.69460547
72Salmonella infection_Homo sapiens_hsa051320.69244142
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.68234935
74Hepatitis C_Homo sapiens_hsa051600.66828360
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65694155
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65663274
77Phagosome_Homo sapiens_hsa041450.64463190
78African trypanosomiasis_Homo sapiens_hsa051430.60398912
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60365611
80Viral carcinogenesis_Homo sapiens_hsa052030.60235432
81HTLV-I infection_Homo sapiens_hsa051660.59676623
82Alzheimers disease_Homo sapiens_hsa050100.59209564
83Arachidonic acid metabolism_Homo sapiens_hsa005900.58444653
84RNA transport_Homo sapiens_hsa030130.58102370
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57876752
86Chemokine signaling pathway_Homo sapiens_hsa040620.57634367
87Chemical carcinogenesis_Homo sapiens_hsa052040.56936176
88Glutathione metabolism_Homo sapiens_hsa004800.56685560
89Cell cycle_Homo sapiens_hsa041100.56578161
90Lysosome_Homo sapiens_hsa041420.54205655
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52562970
92Systemic lupus erythematosus_Homo sapiens_hsa053220.52092371
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48672539
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48652219
95Selenocompound metabolism_Homo sapiens_hsa004500.47703804
96Fructose and mannose metabolism_Homo sapiens_hsa000510.47639520
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47392457
98Galactose metabolism_Homo sapiens_hsa000520.46225302
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46219452
100Platelet activation_Homo sapiens_hsa046110.46016362
101Fanconi anemia pathway_Homo sapiens_hsa034600.45832765
102Thyroid cancer_Homo sapiens_hsa052160.44725998
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44658048
104Complement and coagulation cascades_Homo sapiens_hsa046100.44565835
105Huntingtons disease_Homo sapiens_hsa050160.43598255
106Purine metabolism_Homo sapiens_hsa002300.42928979
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41378261
108Parkinsons disease_Homo sapiens_hsa050120.40814013
109Small cell lung cancer_Homo sapiens_hsa052220.40608266
110Fatty acid elongation_Homo sapiens_hsa000620.40339680
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.39308650
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38718079
113N-Glycan biosynthesis_Homo sapiens_hsa005100.37592837
114Chronic myeloid leukemia_Homo sapiens_hsa052200.36817222
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36771962
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.35770253
117Linoleic acid metabolism_Homo sapiens_hsa005910.34707170
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33712131
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.33633505
120Regulation of autophagy_Homo sapiens_hsa041400.32341357
121Fat digestion and absorption_Homo sapiens_hsa049750.31844088
122Fatty acid degradation_Homo sapiens_hsa000710.31778277
123Peroxisome_Homo sapiens_hsa041460.29789088
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28336210
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.28327152
126Renin-angiotensin system_Homo sapiens_hsa046140.26793551
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26306361

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