PSME2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.85734417
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.85734417
3antigen processing and presentation of endogenous antigen (GO:0019883)5.82715969
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.87506312
5DNA deamination (GO:0045006)4.42596362
6cytidine deamination (GO:0009972)4.41283329
7cytidine metabolic process (GO:0046087)4.41283329
8cytidine catabolic process (GO:0006216)4.41283329
9type I interferon signaling pathway (GO:0060337)4.30726166
10cellular response to type I interferon (GO:0071357)4.30726166
11response to type I interferon (GO:0034340)4.29308510
12neutrophil activation involved in immune response (GO:0002283)4.04417675
13cellular response to interferon-beta (GO:0035458)3.90579562
14response to interferon-beta (GO:0035456)3.87406038
15positive regulation of antigen processing and presentation (GO:0002579)3.84450177
16NIK/NF-kappaB signaling (GO:0038061)3.84305049
17ribosomal small subunit assembly (GO:0000028)3.83392091
18pyrimidine ribonucleoside catabolic process (GO:0046133)3.79207353
19regulation of RIG-I signaling pathway (GO:0039535)3.78509312
20positive regulation of interferon-alpha production (GO:0032727)3.76824034
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.63642143
22immunoglobulin mediated immune response (GO:0016064)3.61084957
23positive regulation of gamma-delta T cell activation (GO:0046645)3.56783733
24regulation of interferon-alpha production (GO:0032647)3.56717022
25cellular response to zinc ion (GO:0071294)3.55758416
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.54288565
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.47911920
28regulation of antigen processing and presentation (GO:0002577)3.45086617
29regulation of dendritic cell antigen processing and presentation (GO:0002604)3.43068543
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.42757497
31interferon-gamma-mediated signaling pathway (GO:0060333)3.38177316
32response to peptidoglycan (GO:0032494)3.37846590
33regulation of T-helper 1 cell differentiation (GO:0045625)3.37030916
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.33969019
35myeloid dendritic cell activation (GO:0001773)3.33864682
36B cell mediated immunity (GO:0019724)3.31447134
37myeloid dendritic cell differentiation (GO:0043011)3.30035084
38regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.28394853
39respiratory burst (GO:0045730)3.23399142
40positive regulation of natural killer cell differentiation (GO:0032825)3.23308805
41* regulation of cellular amino acid metabolic process (GO:0006521)3.22128107
42ATP synthesis coupled proton transport (GO:0015986)3.21246899
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.21246899
44T cell migration (GO:0072678)3.20189273
45defense response to protozoan (GO:0042832)3.19826340
46negative regulation of viral genome replication (GO:0045071)3.19295373
47negative thymic T cell selection (GO:0045060)3.17905621
48regulation of B cell receptor signaling pathway (GO:0050855)3.17843180
49response to interferon-alpha (GO:0035455)3.17820096
50regulation of alpha-beta T cell proliferation (GO:0046640)3.17723962
51* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16733463
52regulation of regulatory T cell differentiation (GO:0045589)3.15255985
53positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14655752
54* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14188789
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10522392
56positive regulation of interleukin-12 production (GO:0032735)3.10225301
57granulocyte activation (GO:0036230)3.08579569
58sequestering of actin monomers (GO:0042989)3.08384399
59* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06970196
60* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06970196
61positive thymic T cell selection (GO:0045059)3.06221939
62neutrophil activation (GO:0042119)3.06213391
63natural killer cell mediated immunity (GO:0002228)3.05750536
64natural killer cell mediated cytotoxicity (GO:0042267)3.05750536
65* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.05231617
66negative T cell selection (GO:0043383)3.05225480
67* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04481114
68* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04481114
69* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04481114
70cellular response to exogenous dsRNA (GO:0071360)3.04243459
71regulation of interleukin-12 biosynthetic process (GO:0045075)2.99900593
72lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94316116
73regulation of T cell tolerance induction (GO:0002664)2.92849948
74* signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91464169
75* signal transduction involved in DNA damage checkpoint (GO:0072422)2.91464169
76positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91169801
77* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90151057
78regulation of hypersensitivity (GO:0002883)2.89259286
79T-helper 1 type immune response (GO:0042088)2.89051870
80leukocyte aggregation (GO:0070486)2.88270754
81* negative regulation of ligase activity (GO:0051352)2.88038143
82* negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88038143
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87666172
84regulation of chronic inflammatory response (GO:0002676)2.87593925
85response to protozoan (GO:0001562)2.87060046
86regulation of activation of Janus kinase activity (GO:0010533)2.86677716
87* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86268300
88hydrogen peroxide biosynthetic process (GO:0050665)2.86019543
89regulation of type I interferon-mediated signaling pathway (GO:0060338)2.85526796
90cellular response to interleukin-15 (GO:0071350)2.85486516
91* signal transduction involved in cell cycle checkpoint (GO:0072395)2.82658485
92viral transcription (GO:0019083)2.81990190
93T cell costimulation (GO:0031295)2.81757415
94regulation of T cell mediated cytotoxicity (GO:0001914)2.80814661
95negative regulation of myeloid cell apoptotic process (GO:0033033)2.79915492
96lymphocyte costimulation (GO:0031294)2.79830326
97negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.77867124
98reactive oxygen species biosynthetic process (GO:1903409)2.75350575
99dendritic cell differentiation (GO:0097028)2.75154477
100regulation of immunoglobulin secretion (GO:0051023)2.74329353
101positive regulation of interferon-beta production (GO:0032728)2.74258238
102positive regulation of lymphocyte migration (GO:2000403)2.74175334
103negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.73603181
104negative regulation of cell killing (GO:0031342)2.73603181
105antigen processing and presentation via MHC class Ib (GO:0002475)2.73304077
106positive regulation of type 2 immune response (GO:0002830)2.72934334
107positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.72763059
108* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72730942
109response to muramyl dipeptide (GO:0032495)2.72374853
110* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70869839
111cellular response to virus (GO:0098586)2.70327051
112cellular response to interferon-gamma (GO:0071346)2.70213469
113response to interleukin-15 (GO:0070672)2.69945745
114regulation of response to interferon-gamma (GO:0060330)2.69604673
115positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.68656218
116respiratory electron transport chain (GO:0022904)2.68646533
117translational termination (GO:0006415)2.68191169
118positive regulation of humoral immune response (GO:0002922)2.67603236
119proteasome assembly (GO:0043248)2.66992969
120regulation of interleukin-2 biosynthetic process (GO:0045076)2.64759939
121positive regulation of T-helper cell differentiation (GO:0045624)2.64438409
122leukocyte mediated cytotoxicity (GO:0001909)2.64159608
123regulation of chemokine biosynthetic process (GO:0045073)2.62926810
124electron transport chain (GO:0022900)2.62642796
125modulation by symbiont of host immune response (GO:0052553)2.61996203
126positive regulation by symbiont of host defense response (GO:0052509)2.61996203
127modulation by symbiont of host defense response (GO:0052031)2.61996203
128modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61996203
129modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61996203
130positive regulation by organism of defense response of other organism involved in symbiotic interact2.61996203
131positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.60873754
132response to interferon-gamma (GO:0034341)2.60422730
133positive regulation of B cell differentiation (GO:0045579)2.58629116
134regulation of interleukin-12 production (GO:0032655)2.58302661
135actin nucleation (GO:0045010)2.57897305
136regulation of viral genome replication (GO:0045069)2.57584531
137regulation of inflammatory response to antigenic stimulus (GO:0002861)2.56797290
138regulation of interferon-beta biosynthetic process (GO:0045357)2.56052767
139SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.55857473
140regulation of leukocyte mediated cytotoxicity (GO:0001910)2.54229257
141positive regulation of interleukin-2 production (GO:0032743)2.53987776
142monocyte chemotaxis (GO:0002548)2.53434915
143mast cell activation (GO:0045576)2.53023944
144positive regulation of chemokine biosynthetic process (GO:0045080)2.52895018
145lymphocyte chemotaxis (GO:0048247)2.52293946
146positive regulation of T cell migration (GO:2000406)2.51881362
147negative regulation of interleukin-12 production (GO:0032695)2.51677760
148positive regulation of isotype switching (GO:0045830)2.51313466
149detection of bacterium (GO:0016045)2.51208820
150regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.50918843
151regulation of natural killer cell differentiation (GO:0032823)2.50522320
152positive regulation of defense response to virus by host (GO:0002230)2.49430097
153natural killer cell activation (GO:0030101)2.49236190
154regulation of tolerance induction (GO:0002643)2.48108495
155regulation of gamma-delta T cell activation (GO:0046643)2.46507634
156mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46304744
157positive T cell selection (GO:0043368)2.46139201
158* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.45688419
159thymic T cell selection (GO:0045061)2.45188068
160positive regulation of B cell mediated immunity (GO:0002714)2.41572075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.40762814
2* IRF8_21731497_ChIP-ChIP_J774_Mouse4.85416816
3* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.50966647
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.26483373
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.41269648
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33611016
7E2F7_22180533_ChIP-Seq_HELA_Human2.94354146
8* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94003599
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.85415903
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.75282285
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65597560
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52455949
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.47084179
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39135406
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38179685
16* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36987733
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32321529
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.22008212
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21570646
20* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17510695
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16645258
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14391903
23SPI1_23547873_ChIP-Seq_NB4_Human2.09177770
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03592441
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.91706931
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.88149063
27* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86118839
28MYB_26560356_Chip-Seq_TH2_Human1.84231191
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83668723
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80142233
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79180122
32MAF_26560356_Chip-Seq_TH1_Human1.67632369
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63058704
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60313036
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59615055
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57570859
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.54390532
38MYB_26560356_Chip-Seq_TH1_Human1.53988275
39CIITA_25753668_ChIP-Seq_RAJI_Human1.53320837
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52546909
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50301751
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49325968
43GATA1_22025678_ChIP-Seq_K562_Human1.46926893
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45739484
45VDR_21846776_ChIP-Seq_THP-1_Human1.44491262
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.41423025
47VDR_24763502_ChIP-Seq_THP-1_Human1.40685282
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40682442
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.40336388
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40235906
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39931258
52VDR_23849224_ChIP-Seq_CD4+_Human1.39118628
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38802492
54ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36597165
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36234896
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35220927
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34545837
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32993136
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32291008
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29666302
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29380590
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29254237
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.27872811
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27827805
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27537906
66ELK1_19687146_ChIP-ChIP_HELA_Human1.24455630
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23758265
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.23333617
69UTX_26944678_Chip-Seq_JUKART_Human1.21053973
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20478911
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20150460
72MAF_26560356_Chip-Seq_TH2_Human1.19049738
73RUNX_20019798_ChIP-Seq_JUKART_Human1.18849878
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17960332
75SCL_19346495_ChIP-Seq_HPC-7_Human1.17334289
76PU_27001747_Chip-Seq_BMDM_Mouse1.16032197
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16021625
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.15494413
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15339586
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13442579
81MYC_22102868_ChIP-Seq_BL_Human1.12158776
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10412675
83BCL6_27268052_Chip-Seq_Bcells_Human1.09485662
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.08737604
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07728527
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07339156
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06102195
88GATA3_27048872_Chip-Seq_THYMUS_Human1.05708772
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04791816
90* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04342317
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03138314
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02912438
93GATA3_26560356_Chip-Seq_TH2_Human1.02900683
94DCP1A_22483619_ChIP-Seq_HELA_Human1.02591397
95GABP_19822575_ChIP-Seq_HepG2_Human1.02011344
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01992637
97PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01147174
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00637070
99* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00154967
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99265831
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99016800
102FOXP3_21729870_ChIP-Seq_TREG_Human0.98453799
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98134493
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96359138
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95805098
106PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95205323
107E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94078797
108STAT1_20625510_ChIP-Seq_HELA_Human0.93842929
109* XRN2_22483619_ChIP-Seq_HELA_Human0.92557859
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91340224
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90911082
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.90394858
113P300_27268052_Chip-Seq_Bcells_Human0.89614020
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89502460
115MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88927690
116SPI1_23127762_ChIP-Seq_K562_Human0.86887834
117FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86805823
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86319242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.83265226
2MP0009785_altered_susceptibility_to3.89263537
3MP0000685_abnormal_immune_system3.63338104
4MP0002148_abnormal_hypersensitivity_rea3.42025631
5MP0005671_abnormal_response_to3.33229962
6MP0003436_decreased_susceptibility_to3.20538896
7MP0005000_abnormal_immune_tolerance2.96785981
8MP0005025_abnormal_response_to2.96083417
9MP0001790_abnormal_immune_system2.95876302
10MP0005387_immune_system_phenotype2.95876302
11MP0003724_increased_susceptibility_to2.95253326
12MP0006082_CNS_inflammation2.80961877
13MP0001800_abnormal_humoral_immune2.66622922
14MP0002452_abnormal_antigen_presenting2.54183265
15MP0002419_abnormal_innate_immunity2.52522386
16MP0002723_abnormal_immune_serum2.51812898
17MP0003763_abnormal_thymus_physiology2.36886547
18* MP0001819_abnormal_immune_cell2.32874296
19* MP0002420_abnormal_adaptive_immunity2.30078204
20MP0001853_heart_inflammation2.21001782
21MP0002139_abnormal_hepatobiliary_system2.15030176
22MP0009333_abnormal_splenocyte_physiolog2.00175138
23MP0004510_myositis1.99989706
24MP0010155_abnormal_intestine_physiology1.97503022
25* MP0002166_altered_tumor_susceptibility1.92647562
26MP0002405_respiratory_system_inflammati1.92561927
27* MP0002006_tumorigenesis1.90830508
28MP0001845_abnormal_inflammatory_respons1.85641297
29MP0000716_abnormal_immune_system1.85293816
30MP0002398_abnormal_bone_marrow1.85107883
31MP0002138_abnormal_hepatobiliary_system1.80999415
32MP0004947_skin_inflammation1.79818629
33MP0008469_abnormal_protein_level1.70262678
34MP0005464_abnormal_platelet_physiology1.68394299
35MP0005310_abnormal_salivary_gland1.67243304
36MP0001873_stomach_inflammation1.64537930
37MP0009764_decreased_sensitivity_to1.63173066
38MP0003186_abnormal_redox_activity1.61743691
39MP0001533_abnormal_skeleton_physiology1.58869459
40MP0002163_abnormal_gland_morphology1.56417671
41MP0002429_abnormal_blood_cell1.53704172
42MP0002254_reproductive_system_inflammat1.50374050
43MP0001348_abnormal_lacrimal_gland1.49530521
44MP0002722_abnormal_immune_system1.47439651
45MP0000689_abnormal_spleen_morphology1.46662052
46MP0003303_peritoneal_inflammation1.46653712
47MP0000858_altered_metastatic_potential1.41666017
48MP0003448_altered_tumor_morphology1.33406271
49MP0003191_abnormal_cellular_cholesterol1.28936109
50MP0008875_abnormal_xenobiotic_pharmacok1.25078145
51MP0005058_abnormal_lysosome_morphology1.24523158
52MP0006036_abnormal_mitochondrial_physio1.19990756
53MP0001666_abnormal_nutrient_absorption1.18319954
54MP0004782_abnormal_surfactant_physiolog1.17833786
55MP0005397_hematopoietic_system_phenotyp1.17660826
56MP0001545_abnormal_hematopoietic_system1.17660826
57MP0003866_abnormal_defecation1.17509029
58MP0002396_abnormal_hematopoietic_system1.16292758
59MP0005365_abnormal_bile_salt1.14170063
60MP0000490_abnormal_crypts_of1.13500203
61MP0005075_abnormal_melanosome_morpholog1.13340652
62MP0000343_altered_response_to1.11879509
63MP0002277_abnormal_respiratory_mucosa1.09741400
64MP0003183_abnormal_peptide_metabolism1.04949447
65MP0003786_premature_aging1.04579077
66MP0000703_abnormal_thymus_morphology1.04531058
67MP0001346_abnormal_lacrimal_gland1.04203205
68MP0002933_joint_inflammation1.02152181
69MP0005085_abnormal_gallbladder_physiolo1.01128453
70MP0009763_increased_sensitivity_to1.01060474
71MP0003693_abnormal_embryo_hatching0.96018410
72MP0009840_abnormal_foam_cell0.95756553
73MP0010352_gastrointestinal_tract_polyps0.94227333
74MP0003252_abnormal_bile_duct0.92067791
75MP0002132_abnormal_respiratory_system0.90032234
76MP0003300_gastrointestinal_ulcer0.89446386
77MP0002998_abnormal_bone_remodeling0.86473428
78MP0005379_endocrine/exocrine_gland_phen0.84987593
79MP0000604_amyloidosis0.82859498
80MP0002019_abnormal_tumor_incidence0.82485908
81MP0005332_abnormal_amino_acid0.80541169
82MP0008057_abnormal_DNA_replication0.80469251
83MP0004808_abnormal_hematopoietic_stem0.78503334
84MP0008872_abnormal_physiological_respon0.76476355
85MP0005636_abnormal_mineral_homeostasis0.75281587
86MP0000372_irregular_coat_pigmentation0.75255596
87MP0001764_abnormal_homeostasis0.74502485
88MP0003075_altered_response_to0.73737496
89MP0004019_abnormal_vitamin_homeostasis0.73440486
90MP0005165_increased_susceptibility_to0.73350074
91MP0005084_abnormal_gallbladder_morpholo0.72329015
92MP0005645_abnormal_hypothalamus_physiol0.71883990
93MP0010307_abnormal_tumor_latency0.71720208
94MP0002876_abnormal_thyroid_physiology0.70489419
95MP0003172_abnormal_lysosome_physiology0.70068545
96MP0003806_abnormal_nucleotide_metabolis0.69294850
97MP0000609_abnormal_liver_physiology0.68817561
98MP0005390_skeleton_phenotype0.68527606
99MP0004147_increased_porphyrin_level0.68110424
100MP0000465_gastrointestinal_hemorrhage0.68029553
101MP0005174_abnormal_tail_pigmentation0.67763969
102MP0003453_abnormal_keratinocyte_physiol0.67717447
103MP0002136_abnormal_kidney_physiology0.67664862
104MP0005451_abnormal_body_composition0.66594187
105MP0005166_decreased_susceptibility_to0.66318355
106MP0005319_abnormal_enzyme/_coenzyme0.65859414
107MP0009643_abnormal_urine_homeostasis0.65496053
108MP0000249_abnormal_blood_vessel0.65304377
109MP0009278_abnormal_bone_marrow0.64655445
110MP0005360_urolithiasis0.63844517
111MP0002693_abnormal_pancreas_physiology0.63589937
112MP0001881_abnormal_mammary_gland0.63315550
113MP0005584_abnormal_enzyme/coenzyme_acti0.63021556
114MP0008873_increased_physiological_sensi0.62952821
115MP0001663_abnormal_digestive_system0.62940741
116MP0009379_abnormal_foot_pigmentation0.62736243
117MP0005164_abnormal_response_to0.61339829
118MP0002009_preneoplasia0.60499412
119MP0003195_calcinosis0.59955297
120MP0009765_abnormal_xenobiotic_induced0.57383814
121MP0006054_spinal_hemorrhage0.56077190
122MP0000598_abnormal_liver_morphology0.53622991
123MP0001851_eye_inflammation0.52317872

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.50347641
2Elevated erythrocyte sedimentation rate (HP:0003565)5.29443118
3Recurrent abscess formation (HP:0002722)5.19423811
4Recurrent bacterial skin infections (HP:0005406)4.86124686
5Increased IgM level (HP:0003496)4.70678436
6Autoimmune thrombocytopenia (HP:0001973)4.55455941
7Chronic otitis media (HP:0000389)4.24086613
8Recurrent gram-negative bacterial infections (HP:0005420)4.03419509
9Myositis (HP:0100614)3.99027440
10Recurrent fungal infections (HP:0002841)3.84219747
11Mediastinal lymphadenopathy (HP:0100721)3.66197320
12Recurrent skin infections (HP:0001581)3.54450835
13Recurrent viral infections (HP:0004429)3.54436806
14Abnormality of macrophages (HP:0004311)3.51264684
15Recurrent bronchitis (HP:0002837)3.44956627
16Vasculitis (HP:0002633)3.40116997
17Thrombocytosis (HP:0001894)3.36691852
18Orchitis (HP:0100796)3.36242053
19Abnormality of T cell number (HP:0011839)3.30109057
20Hypergammaglobulinemia (HP:0010702)3.30009904
21Autoimmune hemolytic anemia (HP:0001890)3.26999728
22Mitochondrial inheritance (HP:0001427)3.25400686
23Recurrent cutaneous fungal infections (HP:0011370)3.25025930
24Chronic mucocutaneous candidiasis (HP:0002728)3.25025930
25Abnormality of T cell physiology (HP:0011840)3.20867875
26Optic neuritis (HP:0100653)3.19730725
27Retrobulbar optic neuritis (HP:0100654)3.19730725
28Nasal polyposis (HP:0100582)3.15711213
29Acute necrotizing encephalopathy (HP:0006965)3.15350107
30Abnormality of T cells (HP:0002843)3.12701553
31Pustule (HP:0200039)3.04683387
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.03912272
33Abnormal mitochondria in muscle tissue (HP:0008316)2.99621835
34Abnormality of B cell number (HP:0010975)2.94809703
35Hepatocellular necrosis (HP:0001404)2.93073820
36Aplastic anemia (HP:0001915)2.91577991
37Basal ganglia calcification (HP:0002135)2.91201498
38Increased CSF lactate (HP:0002490)2.90361372
39Gingivitis (HP:0000230)2.89628326
40Petechiae (HP:0000967)2.88654116
41Stomatitis (HP:0010280)2.85631559
42Gastrointestinal infarctions (HP:0005244)2.84670307
43Increased hepatocellular lipid droplets (HP:0006565)2.84633975
44Hepatic necrosis (HP:0002605)2.83305218
45Abnormality of the nasal mucosa (HP:0000433)2.82708341
46Obstructive lung disease (HP:0006536)2.81427859
47Chronic obstructive pulmonary disease (HP:0006510)2.81427859
48T lymphocytopenia (HP:0005403)2.80479567
49Acute encephalopathy (HP:0006846)2.75863629
50Vacuolated lymphocytes (HP:0001922)2.72620715
51Meningitis (HP:0001287)2.71302046
52B lymphocytopenia (HP:0010976)2.70486167
53Eosinophilia (HP:0001880)2.70198734
54Increased intramyocellular lipid droplets (HP:0012240)2.67434424
55IgG deficiency (HP:0004315)2.66497573
56Lipid accumulation in hepatocytes (HP:0006561)2.66495608
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65478389
58Interstitial pulmonary disease (HP:0006530)2.65283752
59Progressive macrocephaly (HP:0004481)2.61534142
60IgM deficiency (HP:0002850)2.61184380
61Urticaria (HP:0001025)2.60599852
62Joint swelling (HP:0001386)2.59997328
63Leukocytosis (HP:0001974)2.59712067
64Granulocytopenia (HP:0001913)2.59620892
65Abnormality of cells of the erythroid lineage (HP:0012130)2.58242083
66Periodontitis (HP:0000704)2.57837150
67Renal Fanconi syndrome (HP:0001994)2.52988157
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.51264543
69Pulmonary infiltrates (HP:0002113)2.51198289
70Combined immunodeficiency (HP:0005387)2.50384281
71Systemic lupus erythematosus (HP:0002725)2.49272693
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.49013868
73Severe combined immunodeficiency (HP:0004430)2.46897314
74Chronic sinusitis (HP:0011109)2.45391383
75Abnormal number of erythroid precursors (HP:0012131)2.44440154
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43686469
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43686469
783-Methylglutaconic aciduria (HP:0003535)2.42538101
79Increased muscle lipid content (HP:0009058)2.39173431
80Abnormality of eosinophils (HP:0001879)2.38910060
81Hemoptysis (HP:0002105)2.36614117
82Reticulocytopenia (HP:0001896)2.35387215
83Recurrent pneumonia (HP:0006532)2.34089465
84Lymphopenia (HP:0001888)2.34075773
85Gingival bleeding (HP:0000225)2.33688737
86Agammaglobulinemia (HP:0004432)2.32409353
87Hypoproteinemia (HP:0003075)2.31398719
88Cerebral edema (HP:0002181)2.30677497
89Panhypogammaglobulinemia (HP:0003139)2.27114176
90Exertional dyspnea (HP:0002875)2.25060514
91Generalized aminoaciduria (HP:0002909)2.24483778
92Recurrent lower respiratory tract infections (HP:0002783)2.24227443
93Cellulitis (HP:0100658)2.22811664
94Purpura (HP:0000979)2.22379352
95Chronic diarrhea (HP:0002028)2.20904479
96Keratoconjunctivitis (HP:0001096)2.20656040
97Increased IgE level (HP:0003212)2.20443471
98IgA deficiency (HP:0002720)2.19570343
99Encephalitis (HP:0002383)2.17666102
100Keratoconjunctivitis sicca (HP:0001097)2.17224906
101Increased serum lactate (HP:0002151)2.15153659
102Spontaneous hematomas (HP:0007420)2.12586807
103Oral leukoplakia (HP:0002745)2.12193457
104Skin ulcer (HP:0200042)2.11640270
105Abnormality of the pleura (HP:0002103)2.10608575
106Inflammation of the large intestine (HP:0002037)2.09540385
107Lactic acidosis (HP:0003128)2.08631812
108Type I transferrin isoform profile (HP:0003642)2.07901271
109Acute hepatic failure (HP:0006554)2.07706770
110Pulmonary fibrosis (HP:0002206)2.07251373
111Dicarboxylic aciduria (HP:0003215)2.05501423
112Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05501423
113Pallor (HP:0000980)2.04505798
114Poor head control (HP:0002421)2.04035830
115Pancytopenia (HP:0001876)2.03131733
116Neutropenia (HP:0001875)2.02119266
117Glycosuria (HP:0003076)2.01452787
118Abnormality of urine glucose concentration (HP:0011016)2.01452787
119Osteomyelitis (HP:0002754)2.00947237
120Gastrointestinal inflammation (HP:0004386)2.00211484
121Gastrointestinal stroma tumor (HP:0100723)1.97532671
122Anorexia (HP:0002039)1.97191208
123Arterial thrombosis (HP:0004420)1.96845184
124Abnormality of the prostate (HP:0008775)1.94897255
125Gangrene (HP:0100758)1.94337492
126Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.91871896
127Hepatosplenomegaly (HP:0001433)1.91759960
128Nausea (HP:0002018)1.90834725
129Tetraparesis (HP:0002273)1.89080216
130Epistaxis (HP:0000421)1.88294759
131Bronchitis (HP:0012387)1.87693482
132Hypochromic anemia (HP:0001931)1.86044486
133Colitis (HP:0002583)1.85681082
134Prostate neoplasm (HP:0100787)1.84944110
135Skin rash (HP:0000988)1.82620978
136Arthralgia (HP:0002829)1.82575199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.10940444
2MAP3K144.10375991
3TBK13.39577512
4TYK23.36388891
5MAP4K13.07823097
6NME23.05980873
7IKBKE3.05814978
8JAK32.95413610
9IRAK42.76678112
10TXK2.76533330
11BLK2.64888895
12PIM22.54332243
13IKBKB2.43319870
14IRAK32.23092865
15PBK2.14746572
16ZAP702.10615545
17KIT1.99601483
18MST41.84641282
19JAK11.82734099
20FGFR41.77725622
21KDR1.69099884
22ERN11.63842567
23BTK1.59193705
24TEC1.56201373
25SYK1.53245091
26RPS6KA41.51593865
27CHUK1.51276145
28FES1.39564429
29TESK11.37470563
30SCYL21.33594410
31RIPK41.31726239
32PIM11.25115572
33MAPKAPK31.24250383
34CSK1.19941440
35NEK91.18649927
36DAPK11.18459255
37MAP3K131.17994104
38EIF2AK11.16503155
39LCK1.15007557
40ZAK1.07819684
41LRRK21.06906637
42LYN1.06027744
43TESK21.05566841
44NLK1.04804048
45NEK11.04635504
46CSF1R1.03656475
47GRK71.03054065
48EIF2AK20.98269083
49ITK0.97636305
50STK100.96795427
51MST1R0.96305947
52TAOK30.94948625
53ACVR1B0.91324794
54ARAF0.91144455
55FLT30.90210791
56EIF2AK30.89947534
57FGFR30.87371375
58SMG10.86669787
59JAK20.83965772
60ABL20.83677131
61HCK0.82854432
62STK40.82460786
63STK160.80245229
64LIMK10.78169442
65EPHB10.76532243
66TAF10.76325582
67GRK60.75474297
68SRPK10.74302579
69TAOK20.73982925
70TGFBR10.70533586
71EPHA30.68948087
72IRAK10.68904408
73MAP2K30.68254076
74CDK80.67376629
75TNK20.66232836
76MYLK0.65875149
77BMPR20.63983693
78PDK20.61262892
79MAP3K120.60988990
80PRKCD0.59518729
81BUB10.59386016
82RPS6KA50.56772943
83MAP3K110.55027521
84MAPKAPK20.54365425
85VRK10.53071282
86PRKCQ0.52927363
87MAP3K30.51994120
88MATK0.50999435
89TGFBR20.47880354
90BCKDK0.46723647
91MAP2K60.46700399
92GRK10.45475440
93ADRBK20.44710042
94DAPK30.43998299
95MARK30.43167489
96PRKG20.42120404
97TLK10.40914066
98PTK60.40722920
99ABL10.39815827
100OXSR10.39766463
101RPS6KA60.38541329
102PIK3CG0.38360751
103SIK30.37931410
104IGF1R0.36606612
105MAP2K20.35375158
106MAPK110.34586519
107CDK40.34190921
108MAPKAPK50.33479791
109CLK10.33092789
110CSNK2A10.32038388
111BCR0.30951662
112MAP3K80.30817974
113ILK0.30804865
114GRK50.30784415
115NME10.30621597
116RPS6KB20.30540447
117MUSK0.30255529
118FGR0.29301282
119MAP3K50.29050614
120PLK40.27677312
121PAK40.27503657
122BMPR1B0.27462465
123CSNK2A20.27345813
124YES10.27039387
125TRPM70.26877617
126STK240.26603476
127ATR0.26543863
128NUAK10.24247019

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.41578933
2Allograft rejection_Homo sapiens_hsa053303.36026532
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.14296084
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.72358086
5Leishmaniasis_Homo sapiens_hsa051402.57065574
6Primary immunodeficiency_Homo sapiens_hsa053402.56911782
7Ribosome_Homo sapiens_hsa030102.52646481
8* Proteasome_Homo sapiens_hsa030502.49440453
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.47458435
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.25403775
11Measles_Homo sapiens_hsa051622.22030950
12Legionellosis_Homo sapiens_hsa051342.15619906
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10619377
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04480685
15Autoimmune thyroid disease_Homo sapiens_hsa053201.99734205
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89799657
17Type I diabetes mellitus_Homo sapiens_hsa049401.88258266
18* Antigen processing and presentation_Homo sapiens_hsa046121.81953356
19Herpes simplex infection_Homo sapiens_hsa051681.79589609
20Staphylococcus aureus infection_Homo sapiens_hsa051501.76557135
21Pertussis_Homo sapiens_hsa051331.74643799
22Asthma_Homo sapiens_hsa053101.70624528
23Influenza A_Homo sapiens_hsa051641.61719191
24Osteoclast differentiation_Homo sapiens_hsa043801.46667922
25Malaria_Homo sapiens_hsa051441.46271573
26DNA replication_Homo sapiens_hsa030301.40154413
27TNF signaling pathway_Homo sapiens_hsa046681.39339311
28Hematopoietic cell lineage_Homo sapiens_hsa046401.38871265
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33852441
30Toxoplasmosis_Homo sapiens_hsa051451.28336406
31Tuberculosis_Homo sapiens_hsa051521.28251826
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27267785
33Apoptosis_Homo sapiens_hsa042101.27254320
34Viral myocarditis_Homo sapiens_hsa054161.22493582
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.22162393
36Sulfur metabolism_Homo sapiens_hsa009201.21526768
37Rheumatoid arthritis_Homo sapiens_hsa053231.19167188
38African trypanosomiasis_Homo sapiens_hsa051431.17166026
39Salmonella infection_Homo sapiens_hsa051321.12332535
40Protein export_Homo sapiens_hsa030601.09057405
41Shigellosis_Homo sapiens_hsa051311.08748621
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01204007
43Base excision repair_Homo sapiens_hsa034100.97884079
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96818646
45B cell receptor signaling pathway_Homo sapiens_hsa046620.94453590
46T cell receptor signaling pathway_Homo sapiens_hsa046600.93589308
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93161829
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89317943
49Mismatch repair_Homo sapiens_hsa034300.87891836
50Chemokine signaling pathway_Homo sapiens_hsa040620.87802686
51Pyrimidine metabolism_Homo sapiens_hsa002400.85552454
52Hepatitis B_Homo sapiens_hsa051610.85468071
53Hepatitis C_Homo sapiens_hsa051600.84471154
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.80511122
55Other glycan degradation_Homo sapiens_hsa005110.80104918
56One carbon pool by folate_Homo sapiens_hsa006700.80028026
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78075274
58Epstein-Barr virus infection_Homo sapiens_hsa051690.76611438
59Homologous recombination_Homo sapiens_hsa034400.73708345
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71270220
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70477884
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69032866
63Caffeine metabolism_Homo sapiens_hsa002320.68925799
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68249452
65Folate biosynthesis_Homo sapiens_hsa007900.66819156
66p53 signaling pathway_Homo sapiens_hsa041150.66019814
67Phagosome_Homo sapiens_hsa041450.65383466
68RNA polymerase_Homo sapiens_hsa030200.64571015
69Parkinsons disease_Homo sapiens_hsa050120.64032971
70Oxidative phosphorylation_Homo sapiens_hsa001900.62228129
71Fat digestion and absorption_Homo sapiens_hsa049750.61327655
72Lysosome_Homo sapiens_hsa041420.60638335
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59832550
74Pentose phosphate pathway_Homo sapiens_hsa000300.58402430
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.57670792
76Chemical carcinogenesis_Homo sapiens_hsa052040.57300172
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57266988
78Vitamin digestion and absorption_Homo sapiens_hsa049770.55477297
79Fructose and mannose metabolism_Homo sapiens_hsa000510.50895584
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49188332
81Phenylalanine metabolism_Homo sapiens_hsa003600.48784879
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48541811
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.47744656
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.47310479
85Nucleotide excision repair_Homo sapiens_hsa034200.47288462
86Viral carcinogenesis_Homo sapiens_hsa052030.46164527
87Acute myeloid leukemia_Homo sapiens_hsa052210.45923318
88Fatty acid elongation_Homo sapiens_hsa000620.45020557
89Histidine metabolism_Homo sapiens_hsa003400.44974130
90RNA degradation_Homo sapiens_hsa030180.43961774
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43596250
92Sulfur relay system_Homo sapiens_hsa041220.43357043
93Purine metabolism_Homo sapiens_hsa002300.43009015
94Non-homologous end-joining_Homo sapiens_hsa034500.42251536
95Renin-angiotensin system_Homo sapiens_hsa046140.42055094
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42043614
97Spliceosome_Homo sapiens_hsa030400.41762112
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41122566
99Arachidonic acid metabolism_Homo sapiens_hsa005900.41106269
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39660484
101Linoleic acid metabolism_Homo sapiens_hsa005910.39499255
102Mineral absorption_Homo sapiens_hsa049780.38879175
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38514449
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37862750
105Complement and coagulation cascades_Homo sapiens_hsa046100.37151380
106HTLV-I infection_Homo sapiens_hsa051660.37103618
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36734765
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35350319
109Peroxisome_Homo sapiens_hsa041460.34486082
110Tryptophan metabolism_Homo sapiens_hsa003800.34364130
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32714618
112Alzheimers disease_Homo sapiens_hsa050100.30963086
113Systemic lupus erythematosus_Homo sapiens_hsa053220.30927447
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30916215
115Prolactin signaling pathway_Homo sapiens_hsa049170.30335973
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28769564
117Metabolic pathways_Homo sapiens_hsa011000.28535279
118Small cell lung cancer_Homo sapiens_hsa052220.28394591
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27979093
120N-Glycan biosynthesis_Homo sapiens_hsa005100.27959930
121Glutathione metabolism_Homo sapiens_hsa004800.27906717
122Retinol metabolism_Homo sapiens_hsa008300.27798527
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27472407
124Fatty acid degradation_Homo sapiens_hsa000710.27214313
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26351604
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25961656
127Huntingtons disease_Homo sapiens_hsa050160.25794157

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