PSME2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.69609203
2cytidine metabolic process (GO:0046087)5.28269444
3cytidine catabolic process (GO:0006216)5.28269444
4cytidine deamination (GO:0009972)5.28269444
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.15329911
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.56289072
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.45674078
8mast cell activation (GO:0045576)3.95763317
9mast cell degranulation (GO:0043303)3.92036894
10mast cell activation involved in immune response (GO:0002279)3.92036894
11regulation of activation of Janus kinase activity (GO:0010533)3.81036662
12cellular response to interleukin-15 (GO:0071350)3.77076156
13immunoglobulin mediated immune response (GO:0016064)3.75677772
14regulation of regulatory T cell differentiation (GO:0045589)3.68192491
15response to interferon-beta (GO:0035456)3.53828092
16ATP synthesis coupled proton transport (GO:0015986)3.52382737
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52382737
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51816222
19positive regulation of T cell mediated cytotoxicity (GO:0001916)3.50573757
20negative regulation of mast cell activation (GO:0033004)3.48561024
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44348456
22positive regulation of defense response to virus by host (GO:0002230)3.34171028
23positive thymic T cell selection (GO:0045059)3.26315310
24B cell mediated immunity (GO:0019724)3.26158046
25regulation of B cell receptor signaling pathway (GO:0050855)3.25835982
26regulation of cellular amino acid metabolic process (GO:0006521)3.25543922
27regulation of T cell mediated cytotoxicity (GO:0001914)3.23597585
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09114881
29positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.07383568
30regulation of chronic inflammatory response (GO:0002676)3.05127706
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03193200
32positive regulation of interleukin-8 secretion (GO:2000484)3.01044940
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.00741797
34positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.99749525
35positive regulation of T-helper 1 type immune response (GO:0002827)2.99644714
36regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.98847566
37response to interleukin-15 (GO:0070672)2.97058888
38antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.96225513
39positive T cell selection (GO:0043368)2.93716201
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93366993
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93366993
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93366993
43regulation of leukocyte mediated cytotoxicity (GO:0001910)2.92955586
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90553381
45regulation of interleukin-8 secretion (GO:2000482)2.89500406
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89193342
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89193342
48negative T cell selection (GO:0043383)2.89174006
49positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87593200
50negative regulation of viral genome replication (GO:0045071)2.86141700
51regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.85478051
52kynurenine metabolic process (GO:0070189)2.85434360
53respiratory electron transport chain (GO:0022904)2.84451772
54electron transport chain (GO:0022900)2.83725637
55indole-containing compound catabolic process (GO:0042436)2.83371940
56indolalkylamine catabolic process (GO:0046218)2.83371940
57tryptophan catabolic process (GO:0006569)2.83371940
58lymphocyte costimulation (GO:0031294)2.77117652
59regulation of antigen processing and presentation (GO:0002577)2.76998957
60leukocyte degranulation (GO:0043299)2.76663546
61regulation of T-helper 1 type immune response (GO:0002825)2.76292766
62T cell costimulation (GO:0031295)2.76164548
63signal transduction involved in DNA integrity checkpoint (GO:0072401)2.75770848
64signal transduction involved in DNA damage checkpoint (GO:0072422)2.75770848
65interferon-gamma-mediated signaling pathway (GO:0060333)2.74926838
66positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.74772684
67positive regulation of interleukin-17 production (GO:0032740)2.73603845
68regulation of memory T cell differentiation (GO:0043380)2.70248720
69positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.69904728
70signal transduction involved in cell cycle checkpoint (GO:0072395)2.69890978
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69157884
72regulation of alpha-beta T cell proliferation (GO:0046640)2.67207608
73protein complex biogenesis (GO:0070271)2.66972669
74Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66789367
75positive regulation of cell killing (GO:0031343)2.65252781
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65165335
77T cell migration (GO:0072678)2.65091946
78negative regulation of ligase activity (GO:0051352)2.64746649
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64746649
80regulation of interleukin-12 biosynthetic process (GO:0045075)2.64591219
81antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.64506889
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64137638
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64103241
84negative regulation of T cell apoptotic process (GO:0070233)2.63514938
85lymphocyte chemotaxis (GO:0048247)2.63083642
86T cell receptor signaling pathway (GO:0050852)2.58278758
87regulation of cell killing (GO:0031341)2.58132211
88regulation of gamma-delta T cell differentiation (GO:0045586)2.57825386
89lysosome localization (GO:0032418)2.57678928
90regulation of T cell receptor signaling pathway (GO:0050856)2.57057377
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56604330
92actin nucleation (GO:0045010)2.55683682
93tryptophan metabolic process (GO:0006568)2.55470465
94L-fucose catabolic process (GO:0042355)2.55056239
95fucose catabolic process (GO:0019317)2.55056239
96L-fucose metabolic process (GO:0042354)2.55056239
97platelet dense granule organization (GO:0060155)2.54531088
98negative thymic T cell selection (GO:0045060)2.52470170
99inositol phosphate dephosphorylation (GO:0046855)2.50392135
100phosphorylated carbohydrate dephosphorylation (GO:0046838)2.50392135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.66113079
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.82705557
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.83129242
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38472842
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.15363962
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12337438
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.07107975
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.05577541
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03491515
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81872950
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79135907
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77758535
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76693352
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.62959983
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25955488
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.23946638
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21759507
18VDR_23849224_ChIP-Seq_CD4+_Human2.17937187
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10289277
20VDR_22108803_ChIP-Seq_LS180_Human2.02859481
21ZNF274_21170338_ChIP-Seq_K562_Hela2.01521457
22GATA3_26560356_Chip-Seq_TH2_Human2.01065617
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95122300
24MYB_26560356_Chip-Seq_TH2_Human1.91165020
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89736633
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89063246
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80167468
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.77079800
29RUNX_20019798_ChIP-Seq_JUKART_Human1.72549866
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61731664
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59507491
32GATA3_27048872_Chip-Seq_THYMUS_Human1.59393104
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.59349876
34FOXP3_21729870_ChIP-Seq_TREG_Human1.57492650
35ELK1_19687146_ChIP-ChIP_HELA_Human1.56710885
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.48157699
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44184377
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44179810
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.43704187
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43704187
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39907643
42TP53_22573176_ChIP-Seq_HFKS_Human1.32810892
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32635167
44AR_20517297_ChIP-Seq_VCAP_Human1.32588531
45SPI1_23547873_ChIP-Seq_NB4_Human1.30899636
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28785638
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27537296
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24061275
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23720318
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23211550
51MYC_18940864_ChIP-ChIP_HL60_Human1.22286575
52TAF2_19829295_ChIP-Seq_ESCs_Human1.19883688
53CIITA_25753668_ChIP-Seq_RAJI_Human1.19452484
54PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18526530
55TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17224284
56MYB_26560356_Chip-Seq_TH1_Human1.16908930
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.16315065
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.16110146
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14956397
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13615211
61GATA3_26560356_Chip-Seq_TH1_Human1.11668257
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10674577
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08539463
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07704868
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.07589784
66NCOR_22424771_ChIP-Seq_293T_Human1.06547181
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.06283846
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06126238
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04674358
70NANOG_19829295_ChIP-Seq_ESCs_Human1.03680719
71SOX2_19829295_ChIP-Seq_ESCs_Human1.03680719
72GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03678626
73NANOG_20526341_ChIP-Seq_ESCs_Human1.03524605
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03254654
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03244025
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01241788
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00782710
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00531779
79P300_27268052_Chip-Seq_Bcells_Human0.99983504
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99873447
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99811921
82EWS_26573619_Chip-Seq_HEK293_Human0.99238251
83BCL6_27268052_Chip-Seq_Bcells_Human0.98710436
84IRF1_19129219_ChIP-ChIP_H3396_Human0.98110437
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.97971131
86MYC_19829295_ChIP-Seq_ESCs_Human0.97606566
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97157655
88ER_23166858_ChIP-Seq_MCF-7_Human0.94897395
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94733632
90HOXB7_26014856_ChIP-Seq_BT474_Human0.94259406
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94258962
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93256286
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93238362
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93024001
95IGF1R_20145208_ChIP-Seq_DFB_Human0.92371766
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90123523
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.87888917
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87319104
99STAT1_20625510_ChIP-Seq_HELA_Human0.86957964
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.86058848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.77290269
2MP0001835_abnormal_antigen_presentation4.76629071
3MP0002166_altered_tumor_susceptibility3.26589948
4MP0009785_altered_susceptibility_to3.02410715
5MP0002138_abnormal_hepatobiliary_system2.96646748
6MP0002006_tumorigenesis2.81784862
7MP0000685_abnormal_immune_system2.72364142
8MP0001800_abnormal_humoral_immune2.66853172
9MP0002148_abnormal_hypersensitivity_rea2.66590960
10MP0003763_abnormal_thymus_physiology2.61376194
11MP0005000_abnormal_immune_tolerance2.60338318
12MP0009333_abnormal_splenocyte_physiolog2.54533571
13MP0005387_immune_system_phenotype2.34863193
14MP0001790_abnormal_immune_system2.34863193
15MP0006082_CNS_inflammation2.30194190
16MP0003724_increased_susceptibility_to2.24072949
17MP0002723_abnormal_immune_serum2.20159050
18MP0001873_stomach_inflammation2.15730052
19MP0008875_abnormal_xenobiotic_pharmacok2.12828051
20MP0002452_abnormal_antigen_presenting2.08149867
21MP0002420_abnormal_adaptive_immunity2.07887169
22MP0001819_abnormal_immune_cell2.05711405
23MP0003436_decreased_susceptibility_to2.00339214
24MP0003195_calcinosis1.97634798
25MP0005025_abnormal_response_to1.97187124
26MP0003806_abnormal_nucleotide_metabolis1.96799283
27MP0003866_abnormal_defecation1.94687826
28MP0010155_abnormal_intestine_physiology1.87808580
29MP0005075_abnormal_melanosome_morpholog1.83511157
30MP0004147_increased_porphyrin_level1.82597128
31MP0006072_abnormal_retinal_apoptosis1.76326961
32MP0008872_abnormal_physiological_respon1.62931687
33MP0002419_abnormal_innate_immunity1.61887181
34MP0005645_abnormal_hypothalamus_physiol1.55439891
35MP0009764_decreased_sensitivity_to1.54349611
36MP0002398_abnormal_bone_marrow1.53564112
37MP0000716_abnormal_immune_system1.50705579
38MP0001845_abnormal_inflammatory_respons1.50103857
39MP0001853_heart_inflammation1.49552405
40MP0002933_joint_inflammation1.40023873
41MP0000689_abnormal_spleen_morphology1.38609450
42MP0003786_premature_aging1.32711167
43MP0002876_abnormal_thyroid_physiology1.27630268
44MP0001533_abnormal_skeleton_physiology1.25902456
45MP0003646_muscle_fatigue1.22718588
46MP0002722_abnormal_immune_system1.21482042
47MP0002429_abnormal_blood_cell1.20796165
48MP0004145_abnormal_muscle_electrophysio1.19354272
49MP0002405_respiratory_system_inflammati1.19217165
50MP0006036_abnormal_mitochondrial_physio1.17506517
51MP0008469_abnormal_protein_level1.15508289
52MP0002837_dystrophic_cardiac_calcinosis1.12529798
53MP0005464_abnormal_platelet_physiology1.09791855
54MP0001986_abnormal_taste_sensitivity1.08895916
55MP0005646_abnormal_pituitary_gland1.08652789
56MP0001968_abnormal_touch/_nociception1.08477002
57MP0000703_abnormal_thymus_morphology1.08265200
58MP0001919_abnormal_reproductive_system1.07375191
59MP0001501_abnormal_sleep_pattern1.06604135
60MP0001765_abnormal_ion_homeostasis1.03958365
61MP0000372_irregular_coat_pigmentation1.02561956
62MP0005551_abnormal_eye_electrophysiolog1.00772934
63MP0002163_abnormal_gland_morphology1.00265208
64MP0001905_abnormal_dopamine_level0.97501180
65MP0004947_skin_inflammation0.95291093
66MP0005174_abnormal_tail_pigmentation0.91478762
67MP0005636_abnormal_mineral_homeostasis0.88828149
68MP0005377_hearing/vestibular/ear_phenot0.85612761
69MP0003878_abnormal_ear_physiology0.85612761
70MP0005389_reproductive_system_phenotype0.84466765
71MP0002102_abnormal_ear_morphology0.84380345
72MP0004510_myositis0.84218022
73MP0002693_abnormal_pancreas_physiology0.83143298
74MP0008877_abnormal_DNA_methylation0.82732892
75MP0010386_abnormal_urinary_bladder0.80996686
76MP0001727_abnormal_embryo_implantation0.80219765
77MP0005084_abnormal_gallbladder_morpholo0.79770595
78MP0002736_abnormal_nociception_after0.76954797
79MP0009763_increased_sensitivity_to0.76471246
80MP0008995_early_reproductive_senescence0.75374898
81MP0003045_fibrosis0.74304268
82MP0005332_abnormal_amino_acid0.73332354
83MP0005253_abnormal_eye_physiology0.72966827
84MP0003252_abnormal_bile_duct0.72142176
85MP0005360_urolithiasis0.72034133
86MP0009643_abnormal_urine_homeostasis0.71151071
87MP0005410_abnormal_fertilization0.70103907
88MP0005379_endocrine/exocrine_gland_phen0.69902203
89MP0001663_abnormal_digestive_system0.69646220
90MP0002277_abnormal_respiratory_mucosa0.68085822
91MP0005166_decreased_susceptibility_to0.65938766
92MP0002095_abnormal_skin_pigmentation0.64994655
93MP0003638_abnormal_response/metabolism_0.63287088
94MP0005167_abnormal_blood-brain_barrier0.63247340
95MP0003011_delayed_dark_adaptation0.61544249
96MP0005085_abnormal_gallbladder_physiolo0.61530430
97MP0002019_abnormal_tumor_incidence0.60671081
98MP0004142_abnormal_muscle_tone0.60188311
99MP0009765_abnormal_xenobiotic_induced0.59253019
100MP0008775_abnormal_heart_ventricle0.56478278

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.16279941
2Stomatitis (HP:0010280)4.14028615
3Congenital, generalized hypertrichosis (HP:0004540)3.69639076
4Hypoproteinemia (HP:0003075)3.47256898
53-Methylglutaconic aciduria (HP:0003535)3.46088018
6Abnormality of T cell number (HP:0011839)3.42214312
7Acute necrotizing encephalopathy (HP:0006965)3.41473572
8T lymphocytopenia (HP:0005403)3.40290279
9Mitochondrial inheritance (HP:0001427)3.39613118
10Elevated erythrocyte sedimentation rate (HP:0003565)3.38714033
11Severe combined immunodeficiency (HP:0004430)3.28084204
12Abnormality of T cells (HP:0002843)3.22504986
13Abnormality of the prostate (HP:0008775)3.16963319
14Abnormal mitochondria in muscle tissue (HP:0008316)3.10737232
15Increased CSF lactate (HP:0002490)3.08299385
16Attenuation of retinal blood vessels (HP:0007843)3.05451036
17Progressive macrocephaly (HP:0004481)2.99084445
18Constricted visual fields (HP:0001133)2.90081707
19Acute encephalopathy (HP:0006846)2.89269924
20Increased intramyocellular lipid droplets (HP:0012240)2.87527058
21Abnormal delayed hypersensitivity skin test (HP:0002963)2.86937136
22Abolished electroretinogram (ERG) (HP:0000550)2.85909434
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.84765085
24Abnormality of T cell physiology (HP:0011840)2.83151493
25Retrobulbar optic neuritis (HP:0100654)2.82648829
26Optic neuritis (HP:0100653)2.82648829
27Hepatocellular necrosis (HP:0001404)2.82313840
28Increased hepatocellular lipid droplets (HP:0006565)2.81051146
29Congenital stationary night blindness (HP:0007642)2.75776814
30Panhypogammaglobulinemia (HP:0003139)2.73513462
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73151795
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73151795
33Thyroiditis (HP:0100646)2.71271708
34Aplastic anemia (HP:0001915)2.70032808
35Myositis (HP:0100614)2.67729856
36Abnormality of eosinophils (HP:0001879)2.67349443
37Chronic mucocutaneous candidiasis (HP:0002728)2.66777252
38Recurrent cutaneous fungal infections (HP:0011370)2.66777252
39Lipid accumulation in hepatocytes (HP:0006561)2.64423636
40Autoimmune hemolytic anemia (HP:0001890)2.63891345
41Hepatic necrosis (HP:0002605)2.63623519
42Pulmonary infiltrates (HP:0002113)2.59084094
43Abnormality of the renal cortex (HP:0011035)2.53107522
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52856730
45Combined immunodeficiency (HP:0005387)2.52746058
46Abnormality of B cell number (HP:0010975)2.51073084
47Optic disc pallor (HP:0000543)2.50027978
48Pancreatic cysts (HP:0001737)2.47783012
49Increased muscle lipid content (HP:0009058)2.47508942
50Eosinophilia (HP:0001880)2.44043846
51Recurrent fungal infections (HP:0002841)2.43892419
52Renal Fanconi syndrome (HP:0001994)2.41855705
53Abnormality of midbrain morphology (HP:0002418)2.41801900
54Molar tooth sign on MRI (HP:0002419)2.41801900
55Prostate neoplasm (HP:0100787)2.40219483
56Increased IgM level (HP:0003496)2.37908911
57Pustule (HP:0200039)2.34523416
58Pulmonary fibrosis (HP:0002206)2.34460332
59Encephalitis (HP:0002383)2.34103193
60Increased serum lactate (HP:0002151)2.31238605
61Abnormality of macular pigmentation (HP:0008002)2.30515515
62Hemoptysis (HP:0002105)2.28788189
63Stomach cancer (HP:0012126)2.27706167
64Chronic diarrhea (HP:0002028)2.26901719
65Exertional dyspnea (HP:0002875)2.25094248
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24982334
67Meningitis (HP:0001287)2.24982094
68Cerebral edema (HP:0002181)2.22705014
69Orchitis (HP:0100796)2.22455766
70Renal cortical cysts (HP:0000803)2.19374045
71Lactic acidosis (HP:0003128)2.17750543
72Chronic sinusitis (HP:0011109)2.16753044
73IgM deficiency (HP:0002850)2.11937118
74Vasculitis (HP:0002633)2.11188878
75Abnormal rod and cone electroretinograms (HP:0008323)2.10868918
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05134669
77Autoimmune thrombocytopenia (HP:0001973)2.03822964
78Keratoconjunctivitis (HP:0001096)2.03756227
79Agammaglobulinemia (HP:0004432)2.02533613
80Methylmalonic acidemia (HP:0002912)1.99570509
81Granulocytopenia (HP:0001913)1.96591973
82Nephronophthisis (HP:0000090)1.96091339
83B lymphocytopenia (HP:0010976)1.92194167
84Keratoconjunctivitis sicca (HP:0001097)1.91214433
85Abnormality of the pleura (HP:0002103)1.90998334
86Abnormal albumin level (HP:0012116)1.90715877
87Hypoalbuminemia (HP:0003073)1.90715877
88Gangrene (HP:0100758)1.87711393
89Recurrent viral infections (HP:0004429)1.85724529
90Recurrent bronchitis (HP:0002837)1.85537946
91Exercise intolerance (HP:0003546)1.84717751
92Methylmalonic aciduria (HP:0012120)1.83703883
93Respiratory failure (HP:0002878)1.82336748
94Lethargy (HP:0001254)1.82045946
95Type I transferrin isoform profile (HP:0003642)1.81493391
96Testicular atrophy (HP:0000029)1.81430706
97Palpitations (HP:0001962)1.81380780
98Type 2 muscle fiber atrophy (HP:0003554)1.79314758
99Leukocytosis (HP:0001974)1.78430030
100Oral leukoplakia (HP:0002745)1.78035411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.06569952
2KIT3.54581032
3TLK12.91588858
4ZAK2.78894224
5KDR2.62679215
6MAP4K12.58302987
7FRK2.21773682
8ADRBK22.21273425
9FES2.11648754
10TAOK32.08704349
11BMPR1B2.06930003
12BCKDK2.06897977
13TESK22.04020614
14VRK22.03010708
15NUAK12.01104237
16TEC1.91519387
17BMPR21.88619227
18MST41.85204837
19GRK11.75236583
20SYK1.68911063
21IKBKB1.60986633
22MAP4K21.60252192
23ITK1.59877640
24EIF2AK31.52824343
25MAP3K121.45863724
26CDK81.45244104
27EIF2AK11.43371968
28IKBKE1.36525113
29VRK11.31967887
30LIMK11.29738595
31GRK71.22382752
32RIPK41.21370927
33CSF1R1.12209476
34GRK61.10845167
35LYN1.09965702
36LCK1.08205330
37WNK41.07081859
38MAP2K21.05102210
39OXSR11.03902608
40MAP3K141.01904150
41MAPKAPK31.00617925
42DAPK10.99074213
43MYLK0.97516820
44TBK10.96621439
45JAK30.96363043
46TIE10.91715821
47PHKG10.91599186
48PHKG20.91599186
49BUB10.88696791
50PRKCQ0.87676705
51ZAP700.86607492
52EIF2AK20.85661713
53STK160.85148230
54BTK0.84844165
55MATK0.83653667
56TNK20.81705841
57MUSK0.81301773
58CDK190.79799407
59CSK0.75666295
60CAMKK20.74875400
61TGFBR10.72117558
62INSRR0.71825273
63PIK3CG0.70956502
64NEK10.67448180
65GRK50.64765354
66WNK30.64492891
67MAP2K60.64483302
68IGF1R0.63910722
69ERBB30.62377396
70TESK10.61356818
71RPS6KA50.61268603
72ADRBK10.61193043
73JAK10.58635429
74CSNK1G30.57623882
75FLT30.53190793
76ABL10.50580120
77PIK3CA0.49756281
78DAPK20.48958056
79NME10.47195595
80TRIM280.46647307
81HCK0.46135196
82SRPK10.45410976
83BLK0.45237182
84PLK30.44669767
85PLK20.44397996
86STK390.43173848
87OBSCN0.41688578
88ILK0.39050589
89CSNK1A1L0.37487461
90PINK10.37168568
91PRKCA0.36543474
92CSNK1G20.35809202
93TRPM70.34732713
94CSNK1G10.33845644
95PRKCE0.32514554
96EGFR0.32460601
97MAPKAPK20.31762936
98IRAK40.31603418
99INSR0.30782667
100TNIK0.30005110

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.51037716
2Allograft rejection_Homo sapiens_hsa053304.29670560
3Graft-versus-host disease_Homo sapiens_hsa053324.18858495
4Autoimmune thyroid disease_Homo sapiens_hsa053204.15360252
5Proteasome_Homo sapiens_hsa030503.65061814
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.55762887
7Type I diabetes mellitus_Homo sapiens_hsa049403.51890448
8Antigen processing and presentation_Homo sapiens_hsa046123.05803432
9Primary immunodeficiency_Homo sapiens_hsa053402.74971299
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60503038
11Oxidative phosphorylation_Homo sapiens_hsa001902.38401095
12Rheumatoid arthritis_Homo sapiens_hsa053232.04120246
13Caffeine metabolism_Homo sapiens_hsa002322.02787314
14Viral myocarditis_Homo sapiens_hsa054162.01124070
15Parkinsons disease_Homo sapiens_hsa050121.92506711
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80273147
17Staphylococcus aureus infection_Homo sapiens_hsa051501.79761678
18Hematopoietic cell lineage_Homo sapiens_hsa046401.70014461
19Protein export_Homo sapiens_hsa030601.56877085
20RNA polymerase_Homo sapiens_hsa030201.49017829
21Leishmaniasis_Homo sapiens_hsa051401.45477669
22Ribosome_Homo sapiens_hsa030101.44135865
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30766816
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29055904
25Phototransduction_Homo sapiens_hsa047441.21611548
26Alzheimers disease_Homo sapiens_hsa050101.21460037
27Sulfur metabolism_Homo sapiens_hsa009201.07411757
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06941217
29Systemic lupus erythematosus_Homo sapiens_hsa053221.06084255
30Linoleic acid metabolism_Homo sapiens_hsa005911.05918138
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05680476
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02310033
33Huntingtons disease_Homo sapiens_hsa050161.00189260
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99789894
35Nitrogen metabolism_Homo sapiens_hsa009100.98894982
36Tryptophan metabolism_Homo sapiens_hsa003800.96045152
37NF-kappa B signaling pathway_Homo sapiens_hsa040640.95867866
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94001853
39RNA degradation_Homo sapiens_hsa030180.90762075
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86423984
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84858463
42Arachidonic acid metabolism_Homo sapiens_hsa005900.82160788
43Herpes simplex infection_Homo sapiens_hsa051680.77837613
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71084570
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66598552
46T cell receptor signaling pathway_Homo sapiens_hsa046600.66244003
47Cardiac muscle contraction_Homo sapiens_hsa042600.65048621
48One carbon pool by folate_Homo sapiens_hsa006700.65014370
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64038531
50Peroxisome_Homo sapiens_hsa041460.63316960
51Measles_Homo sapiens_hsa051620.63007434
52Homologous recombination_Homo sapiens_hsa034400.61439027
53Pyrimidine metabolism_Homo sapiens_hsa002400.60955851
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60491146
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59187377
56Chemical carcinogenesis_Homo sapiens_hsa052040.58662224
57Toxoplasmosis_Homo sapiens_hsa051450.58053518
58Purine metabolism_Homo sapiens_hsa002300.57977806
59Legionellosis_Homo sapiens_hsa051340.57950670
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.55743783
61Tuberculosis_Homo sapiens_hsa051520.54455703
62Regulation of autophagy_Homo sapiens_hsa041400.54104989
63Propanoate metabolism_Homo sapiens_hsa006400.49991179
64Ether lipid metabolism_Homo sapiens_hsa005650.48137723
65Epstein-Barr virus infection_Homo sapiens_hsa051690.42846523
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41301075
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41153432
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.40972196
69Mismatch repair_Homo sapiens_hsa034300.39928673
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39669497
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39255264
72Collecting duct acid secretion_Homo sapiens_hsa049660.38762998
73Influenza A_Homo sapiens_hsa051640.37422521
74Olfactory transduction_Homo sapiens_hsa047400.36624142
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.36317849
76Fanconi anemia pathway_Homo sapiens_hsa034600.36183195
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35171868
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33393884
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.31139287
80Basal transcription factors_Homo sapiens_hsa030220.30953521
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30836915
82Metabolic pathways_Homo sapiens_hsa011000.28027772
83Retinol metabolism_Homo sapiens_hsa008300.27585208
84Phagosome_Homo sapiens_hsa041450.26852575
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26438817
86Butanoate metabolism_Homo sapiens_hsa006500.24778997
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24595843
88Shigellosis_Homo sapiens_hsa051310.24381894
89Pertussis_Homo sapiens_hsa051330.21799904
90Fat digestion and absorption_Homo sapiens_hsa049750.21154777
91DNA replication_Homo sapiens_hsa030300.19269219
92Spliceosome_Homo sapiens_hsa030400.18876831
93Malaria_Homo sapiens_hsa051440.18726931
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17992417
95beta-Alanine metabolism_Homo sapiens_hsa004100.16087849
96Vitamin digestion and absorption_Homo sapiens_hsa049770.16079013
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14657129
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.14399596
99Selenocompound metabolism_Homo sapiens_hsa004500.13510494
100Nucleotide excision repair_Homo sapiens_hsa034200.12540859

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