PSME3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.36945641
2establishment of integrated proviral latency (GO:0075713)5.18349214
3protein localization to kinetochore (GO:0034501)4.91483061
4folic acid-containing compound biosynthetic process (GO:0009396)4.87657491
5nuclear pore organization (GO:0006999)4.71924502
6nuclear pore complex assembly (GO:0051292)4.67609517
7mitotic nuclear envelope disassembly (GO:0007077)4.62098639
8COPI coating of Golgi vesicle (GO:0048205)4.58239731
9Golgi transport vesicle coating (GO:0048200)4.58239731
10establishment of viral latency (GO:0019043)4.53983737
11membrane disassembly (GO:0030397)4.37293245
12nuclear envelope disassembly (GO:0051081)4.37293245
13protein localization to chromosome, centromeric region (GO:0071459)4.29962434
14mitotic chromosome condensation (GO:0007076)4.20021161
15DNA strand elongation involved in DNA replication (GO:0006271)4.07616114
16DNA replication initiation (GO:0006270)4.05315432
17pre-miRNA processing (GO:0031054)4.04623867
18regulation of translational termination (GO:0006449)3.99660475
19heterochromatin organization (GO:0070828)3.93795784
20DNA strand elongation (GO:0022616)3.85305062
21IMP biosynthetic process (GO:0006188)3.84721609
22mitotic sister chromatid segregation (GO:0000070)3.83237338
23formation of translation preinitiation complex (GO:0001731)3.83231097
24regulation of translational fidelity (GO:0006450)3.82655187
25DNA duplex unwinding (GO:0032508)3.82405167
26DNA geometric change (GO:0032392)3.77966642
27DNA replication-dependent nucleosome assembly (GO:0006335)3.76691590
28DNA replication-dependent nucleosome organization (GO:0034723)3.76691590
29sister chromatid segregation (GO:0000819)3.74999020
30protein maturation by protein folding (GO:0022417)3.69202854
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.66158341
32DNA replication checkpoint (GO:0000076)3.65729351
33mitotic sister chromatid cohesion (GO:0007064)3.63654679
34histone arginine methylation (GO:0034969)3.60198313
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59258050
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59152839
37nuclear envelope organization (GO:0006998)3.53870504
38negative regulation of histone methylation (GO:0031061)3.53755675
39proline biosynthetic process (GO:0006561)3.53328736
40protein complex localization (GO:0031503)3.51381785
41mitotic metaphase plate congression (GO:0007080)3.50791840
42IMP metabolic process (GO:0046040)3.50498243
433-UTR-mediated mRNA stabilization (GO:0070935)3.49015350
44positive regulation of chromosome segregation (GO:0051984)3.47011910
45regulation of RNA export from nucleus (GO:0046831)3.46091351
46nuclear envelope reassembly (GO:0031468)3.42407660
47mitotic nuclear envelope reassembly (GO:0007084)3.42407660
48nucleobase-containing small molecule interconversion (GO:0015949)3.37638667
49nucleobase biosynthetic process (GO:0046112)3.37525191
50telomere maintenance via semi-conservative replication (GO:0032201)3.35026345
51pore complex assembly (GO:0046931)3.34198522
52negative regulation of RNA splicing (GO:0033119)3.33661585
53RNA stabilization (GO:0043489)3.33660219
54mRNA stabilization (GO:0048255)3.33660219
55chromatin assembly (GO:0031497)3.32456151
56regulation of sister chromatid cohesion (GO:0007063)3.31377385
57protein localization to chromosome (GO:0034502)3.31034054
58regulation of histone H3-K9 methylation (GO:0051570)3.30545260
59regulation of spindle organization (GO:0090224)3.24598122
60dosage compensation (GO:0007549)3.22297744
61chromatin assembly or disassembly (GO:0006333)3.20042440
62cellular protein complex localization (GO:0034629)3.19490466
63tRNA aminoacylation for protein translation (GO:0006418)3.13440567
64peptidyl-arginine omega-N-methylation (GO:0035247)3.09902971
65negative regulation of mRNA processing (GO:0050686)3.09346220
66attachment of spindle microtubules to kinetochore (GO:0008608)3.08931187
67translesion synthesis (GO:0019985)3.08545028
68metaphase plate congression (GO:0051310)3.06786918
69DNA conformation change (GO:0071103)3.06580161
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06222918
71histone H2A monoubiquitination (GO:0035518)3.05500916
72rRNA transcription (GO:0009303)3.05016173
73negative regulation of mRNA metabolic process (GO:1903312)3.04936466
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.01028322
75glucocorticoid receptor signaling pathway (GO:0042921)2.99731523
76amino acid activation (GO:0043038)2.98245003
77tRNA aminoacylation (GO:0043039)2.98245003
78spliceosomal tri-snRNP complex assembly (GO:0000244)2.96056836
79regulation of mammary gland epithelial cell proliferation (GO:0033599)2.95829834
80* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95017597
81regulation of mitochondrial translation (GO:0070129)2.94680301
82mitotic G1 DNA damage checkpoint (GO:0031571)2.94596635
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93022045
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93022045
85positive regulation of mitotic sister chromatid separation (GO:1901970)2.93022045
86* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92544977
87telomere maintenance via recombination (GO:0000722)2.91220472
88ribonucleoprotein complex biogenesis (GO:0022613)2.91052259
89protein retention in ER lumen (GO:0006621)2.89733283
90mitotic recombination (GO:0006312)2.88432400
91folic acid metabolic process (GO:0046655)2.86452761
92chromosome condensation (GO:0030261)2.85812223
93ribosome assembly (GO:0042255)2.85499145
94protein export from nucleus (GO:0006611)2.84806383
95regulation of chromosome segregation (GO:0051983)2.84213666
96establishment of chromosome localization (GO:0051303)2.83205334
97* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82595445
98spliceosomal snRNP assembly (GO:0000387)2.82438859
99protoporphyrinogen IX metabolic process (GO:0046501)2.81777362
100peptidyl-lysine dimethylation (GO:0018027)2.81038979
101peptidyl-arginine methylation (GO:0018216)2.80867193
102peptidyl-arginine N-methylation (GO:0035246)2.80867193
103mRNA transport (GO:0051028)2.79921812
104* negative regulation of ligase activity (GO:0051352)2.79185917
105* negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79185917
106maturation of SSU-rRNA (GO:0030490)2.79134368
107pentose-phosphate shunt (GO:0006098)2.78442892
108postreplication repair (GO:0006301)2.78038673
109regulation of nucleobase-containing compound transport (GO:0032239)2.77970245
110DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.76463156
111regulation of mitotic spindle organization (GO:0060236)2.75361254
112ribosome biogenesis (GO:0042254)2.75108143
113telomere maintenance via telomere lengthening (GO:0010833)2.74916905
114DNA replication-independent nucleosome assembly (GO:0006336)2.73542380
115DNA replication-independent nucleosome organization (GO:0034724)2.73542380
116L-serine metabolic process (GO:0006563)2.73295180
117regulation of mRNA stability (GO:0043488)2.72758908
118* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71938389
119purine nucleobase biosynthetic process (GO:0009113)2.71930848
120gene silencing by RNA (GO:0031047)2.70882898
121proteasome assembly (GO:0043248)2.70197297
122tetrahydrofolate metabolic process (GO:0046653)2.69304103
123mitochondrial fusion (GO:0008053)2.69243986
124regulation of DNA damage checkpoint (GO:2000001)2.69015319
125monoubiquitinated protein deubiquitination (GO:0035520)2.68293353
126de novo protein folding (GO:0006458)2.67503997
127retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.66462243
128ATP-dependent chromatin remodeling (GO:0043044)2.66191221
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.64937253
130translational initiation (GO:0006413)2.63746770
131chromosome segregation (GO:0007059)2.63681272
132base-excision repair (GO:0006284)2.63499527
133deoxyribonucleotide biosynthetic process (GO:0009263)2.63053687
134kinetochore organization (GO:0051383)2.62464578
135RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.62137751
136mRNA splicing, via spliceosome (GO:0000398)2.62137751
137regulation of centrosome cycle (GO:0046605)2.61618538
138nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.61191172
139de novo posttranslational protein folding (GO:0051084)2.58880128
140tRNA methylation (GO:0030488)2.58660798
141NADPH regeneration (GO:0006740)2.55781142
142non-recombinational repair (GO:0000726)2.55769237

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.15477732
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.78618598
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91622161
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.42728929
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37504513
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.35531682
7MYC_22102868_ChIP-Seq_BL_Human3.16770658
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94765814
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47149389
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31824231
11AR_21909140_ChIP-Seq_LNCAP_Human2.20941993
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18386160
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.12843644
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10277837
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01778231
16XRN2_22483619_ChIP-Seq_HELA_Human1.91899889
17VDR_21846776_ChIP-Seq_THP-1_Human1.88727507
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82736059
19CIITA_25753668_ChIP-Seq_RAJI_Human1.81006394
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73423516
21* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66909456
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65534606
23* ETS1_20019798_ChIP-Seq_JURKAT_Human1.58919995
24* KDM5A_27292631_Chip-Seq_BREAST_Human1.54989140
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51708804
26* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49845327
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.49407060
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.46668702
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46615950
30TCF7_22412390_ChIP-Seq_EML_Mouse1.45768236
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45147770
32GABP_19822575_ChIP-Seq_HepG2_Human1.44566133
33* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43499836
34* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43479113
35KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43005841
36* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42273943
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40874520
38FOXP3_21729870_ChIP-Seq_TREG_Human1.38742193
39* VDR_23849224_ChIP-Seq_CD4+_Human1.38570159
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37431497
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37254492
42* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35805368
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34285597
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34224457
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33972662
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33052294
47UTX_26944678_Chip-Seq_JUKART_Human1.32310099
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31885593
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31719250
50ZNF263_19887448_ChIP-Seq_K562_Human1.30630038
51MAF_26560356_Chip-Seq_TH1_Human1.29523904
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29471640
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29445972
54TTF2_22483619_ChIP-Seq_HELA_Human1.27850781
55DCP1A_22483619_ChIP-Seq_HELA_Human1.26713724
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26259995
57KDM2B_26808549_Chip-Seq_DND41_Human1.25486914
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.25293948
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25187944
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24421575
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23669962
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22359008
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21318888
64TFEB_21752829_ChIP-Seq_HELA_Human1.19778588
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19689956
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18076765
67* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17762553
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16537012
69* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16284238
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14970302
71* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14354986
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.14352796
73CLOCK_20551151_ChIP-Seq_293T_Human1.13631295
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12568006
75* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12456229
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.10401174
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09569294
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08703983
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08384903
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08201625
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08069056
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08015875
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05567868
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.05131428
85RACK7_27058665_Chip-Seq_MCF-7_Human1.05026433
86* ATF3_27146783_Chip-Seq_COLON_Human1.04668261
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04320201
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.03254678
89CHD1_26751641_Chip-Seq_LNCaP_Human1.02740382
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.02529160
91MYB_26560356_Chip-Seq_TH2_Human1.01520666
92MYB_26560356_Chip-Seq_TH1_Human1.01230673
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00401136
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00341950
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99794239
96* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99520762
97TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99385132
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99252675
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.98978271
100NCOR1_26117541_ChIP-Seq_K562_Human0.98484250
101* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96280667
102MAF_26560356_Chip-Seq_TH2_Human0.96246882
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95632010
104* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95268879
105ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94596006
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94400319
107SCL_19346495_ChIP-Seq_HPC-7_Human0.94314042
108HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93805551
109RUNX1_22412390_ChIP-Seq_EML_Mouse0.93695672
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93517443
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91279986
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91263841
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91159799
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89883118
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89446849
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88820907
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88801788
118VDR_24763502_ChIP-Seq_THP-1_Human0.88033455
119MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87916494
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85763544
121* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84576408
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.83936382
123KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82971907
124SPI1_23547873_ChIP-Seq_NB4_Human0.82219461
125* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82207096
126HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79840334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.11354771
2MP0003111_abnormal_nucleus_morphology4.08673579
3MP0010094_abnormal_chromosome_stability3.80344747
4MP0004957_abnormal_blastocyst_morpholog3.73151567
5MP0003077_abnormal_cell_cycle3.46238641
6MP0010352_gastrointestinal_tract_polyps3.28526667
7MP0008057_abnormal_DNA_replication3.08756510
8MP0002396_abnormal_hematopoietic_system2.84448164
9MP0005451_abnormal_body_composition2.71318279
10MP0001730_embryonic_growth_arrest2.55965862
11MP0003705_abnormal_hypodermis_morpholog2.49071949
12MP0005076_abnormal_cell_differentiation2.48987741
13MP0010307_abnormal_tumor_latency2.46474250
14* MP0000350_abnormal_cell_proliferation2.32293659
15MP0003123_paternal_imprinting2.23675022
16MP0002796_impaired_skin_barrier2.00427811
17MP0008007_abnormal_cellular_replicative1.97266058
18MP0008260_abnormal_autophagy1.95908824
19MP0003656_abnormal_erythrocyte_physiolo1.92953958
20MP0005380_embryogenesis_phenotype1.92112481
21MP0001672_abnormal_embryogenesis/_devel1.92112481
22MP0004808_abnormal_hematopoietic_stem1.90763718
23MP0008058_abnormal_DNA_repair1.90684059
24MP0001697_abnormal_embryo_size1.89874525
25MP0000490_abnormal_crypts_of1.87734620
26MP0003984_embryonic_growth_retardation1.86548232
27MP0002088_abnormal_embryonic_growth/wei1.83363934
28MP0005623_abnormal_meninges_morphology1.78453334
29MP0008932_abnormal_embryonic_tissue1.75533685
30MP0002086_abnormal_extraembryonic_tissu1.75446814
31MP0002080_prenatal_lethality1.73751760
32MP0004197_abnormal_fetal_growth/weight/1.72426928
33MP0005397_hematopoietic_system_phenotyp1.71279289
34MP0001545_abnormal_hematopoietic_system1.71279289
35MP0002084_abnormal_developmental_patter1.68048437
36MP0003300_gastrointestinal_ulcer1.65951756
37MP0002085_abnormal_embryonic_tissue1.61706280
38MP0002019_abnormal_tumor_incidence1.60583511
39MP0003763_abnormal_thymus_physiology1.53929987
40MP0008877_abnormal_DNA_methylation1.53366862
41MP0009278_abnormal_bone_marrow1.52027206
42MP0000703_abnormal_thymus_morphology1.47942912
43MP0003303_peritoneal_inflammation1.47603819
44* MP0002398_abnormal_bone_marrow1.44343244
45MP0000313_abnormal_cell_death1.41215287
46MP0003806_abnormal_nucleotide_metabolis1.40221389
47MP0000678_abnormal_parathyroid_gland1.37225364
48MP0003567_abnormal_fetal_cardiomyocyte1.33868034
49MP0009333_abnormal_splenocyte_physiolog1.33212623
50MP0002722_abnormal_immune_system1.29922852
51MP0003566_abnormal_cell_adhesion1.27054133
52MP0003718_maternal_effect1.26971467
53MP0009672_abnormal_birth_weight1.25592244
54MP0006054_spinal_hemorrhage1.22872181
55MP0000689_abnormal_spleen_morphology1.21923292
56MP0009053_abnormal_anal_canal1.21675334
57MP0004185_abnormal_adipocyte_glucose1.20596357
58MP0003941_abnormal_skin_development1.20453210
59MP0002877_abnormal_melanocyte_morpholog1.20166215
60MP0003221_abnormal_cardiomyocyte_apopto1.19870558
61MP0010030_abnormal_orbit_morphology1.19277647
62MP0001849_ear_inflammation1.17844273
63MP0004264_abnormal_extraembryonic_tissu1.17657256
64MP0003453_abnormal_keratinocyte_physiol1.17545443
65MP0001661_extended_life_span1.17287406
66MP0001915_intracranial_hemorrhage1.15094993
67MP0002060_abnormal_skin_morphology1.13314670
68MP0005257_abnormal_intraocular_pressure1.13126549
69MP0001216_abnormal_epidermal_layer1.12318701
70MP0009697_abnormal_copulation1.12043137
71MP0001346_abnormal_lacrimal_gland1.11350391
72MP0001727_abnormal_embryo_implantation1.10836470
73MP0003121_genomic_imprinting1.10307145
74MP0000537_abnormal_urethra_morphology1.08952894
75MP0006035_abnormal_mitochondrial_morpho1.07110156
76MP0003315_abnormal_perineum_morphology1.06797110
77MP0004858_abnormal_nervous_system1.06427414
78MP0003890_abnormal_embryonic-extraembry1.05859554
79MP0005023_abnormal_wound_healing1.05743031
80MP0004782_abnormal_surfactant_physiolog1.05149294
81MP0000685_abnormal_immune_system1.04492146
82MP0010234_abnormal_vibrissa_follicle1.04183945
83MP0001881_abnormal_mammary_gland1.02863247
84* MP0002429_abnormal_blood_cell1.01549476
85MP0004147_increased_porphyrin_level1.01492377
86MP0000858_altered_metastatic_potential0.97451320
87MP0000733_abnormal_muscle_development0.96924083
88MP0009703_decreased_birth_body0.96621785
89MP0008770_decreased_survivor_rate0.92500533
90MP0002653_abnormal_ependyma_morphology0.91694140
91MP0000627_abnormal_mammary_gland0.89931987
92MP0000762_abnormal_tongue_morphology0.89313509
93MP0004233_abnormal_muscle_weight0.89060868
94MP0005621_abnormal_cell_physiology0.88793850
95MP0004272_abnormal_basement_membrane0.87299160
96MP0003786_premature_aging0.86720231
97MP0008961_abnormal_basal_metabolism0.85115880
98* MP0000716_abnormal_immune_system0.84835236
99MP0000477_abnormal_intestine_morphology0.84579847
100MP0000467_abnormal_esophagus_morphology0.83164833
101MP0001800_abnormal_humoral_immune0.83084193
102MP0005384_cellular_phenotype0.83027832
103MP0001293_anophthalmia0.82824520
104MP0001853_heart_inflammation0.82739447
105MP0002405_respiratory_system_inflammati0.82155714
106MP0000579_abnormal_nail_morphology0.80350235
107MP0000003_abnormal_adipose_tissue0.80212181
108MP0000358_abnormal_cell_content/0.79880916
109MP0005330_cardiomyopathy0.79816358
110MP0003119_abnormal_digestive_system0.75122031
111MP0002132_abnormal_respiratory_system0.75079544
112MP0002925_abnormal_cardiovascular_devel0.74893104
113MP0002210_abnormal_sex_determination0.72719238
114MP0001145_abnormal_male_reproductive0.71671969
115MP0003186_abnormal_redox_activity0.71440677
116MP0000598_abnormal_liver_morphology0.70849611
117MP0000266_abnormal_heart_morphology0.70055410
118MP0002269_muscular_atrophy0.69761348
119MP0006036_abnormal_mitochondrial_physio0.69041745
120MP0000428_abnormal_craniofacial_morphol0.67276980
121MP0000377_abnormal_hair_follicle0.66465140
122MP0002006_tumorigenesis0.66227454
123MP0002970_abnormal_white_adipose0.65355492
124MP0002166_altered_tumor_susceptibility0.64908527
125MP0010155_abnormal_intestine_physiology0.64645293
126MP0005058_abnormal_lysosome_morphology0.64100726
127MP0010630_abnormal_cardiac_muscle0.63592097
128MP0002697_abnormal_eye_size0.63268232
129MP0001243_abnormal_dermal_layer0.63262955
130MP0010771_integument_phenotype0.63030347
131MP0002092_abnormal_eye_morphology0.62566219
132MP0001873_stomach_inflammation0.62111519
133MP0003191_abnormal_cellular_cholesterol0.61367043
134MP0005501_abnormal_skin_physiology0.60936092
135MP0009931_abnormal_skin_appearance0.60509376
136MP0000653_abnormal_sex_gland0.60015109
137MP0001929_abnormal_gametogenesis0.59842909
138MP0003115_abnormal_respiratory_system0.59652322
139MP0002420_abnormal_adaptive_immunity0.59322805
140MP0005666_abnormal_adipose_tissue0.58918749
141MP0004947_skin_inflammation0.57800167

Predicted human phenotypes

RankGene SetZ-score
1Progressive muscle weakness (HP:0003323)3.90755580
2Ependymoma (HP:0002888)3.55648269
3Trismus (HP:0000211)3.48631521
4Microvesicular hepatic steatosis (HP:0001414)3.21077364
5Ragged-red muscle fibers (HP:0003200)3.11744529
6Basal cell carcinoma (HP:0002671)3.11047573
7Poikilocytosis (HP:0004447)3.07842889
8Birth length less than 3rd percentile (HP:0003561)3.02540754
9Selective tooth agenesis (HP:0001592)2.99903375
10Abnormality of the fingertips (HP:0001211)2.91398201
11Medulloblastoma (HP:0002885)2.90389604
12Increased nuchal translucency (HP:0010880)2.90064333
13Rhabdomyosarcoma (HP:0002859)2.88786743
14Rough bone trabeculation (HP:0100670)2.86980992
15Hyperacusis (HP:0010780)2.84383194
16Abnormality of glycolysis (HP:0004366)2.78214308
17Colon cancer (HP:0003003)2.73105322
18Prominent nose (HP:0000448)2.71459264
19High pitched voice (HP:0001620)2.66422759
20Increased serum pyruvate (HP:0003542)2.63069187
21Proximal placement of thumb (HP:0009623)2.62826305
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60511011
23Deviation of the thumb (HP:0009603)2.57582360
24Progressive external ophthalmoplegia (HP:0000590)2.55101912
25Astrocytoma (HP:0009592)2.54651417
26Abnormality of the astrocytes (HP:0100707)2.54651417
27Abnormality of the heme biosynthetic pathway (HP:0010472)2.53382863
28Neoplasm of striated muscle (HP:0009728)2.53371773
29Premature rupture of membranes (HP:0001788)2.50218662
30Volvulus (HP:0002580)2.46905399
31Increased density of long bones (HP:0006392)2.42512353
32Insomnia (HP:0100785)2.42150084
33Vertebral compression fractures (HP:0002953)2.40474073
34Abnormality of the umbilical cord (HP:0010881)2.36792214
35Abnormal gallbladder physiology (HP:0012438)2.34948303
36Cholecystitis (HP:0001082)2.34948303
37Facial hemangioma (HP:0000329)2.34056548
38Degeneration of anterior horn cells (HP:0002398)2.32700749
39Abnormality of the anterior horn cell (HP:0006802)2.32700749
40Reticulocytosis (HP:0001923)2.31702773
41Angiofibromas (HP:0010615)2.31622269
42Adenoma sebaceum (HP:0009720)2.31622269
43Cafe-au-lait spot (HP:0000957)2.31417632
44Overlapping toe (HP:0001845)2.31361123
45Patellar aplasia (HP:0006443)2.30043533
46Short 4th metacarpal (HP:0010044)2.29914745
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29914745
48Oral leukoplakia (HP:0002745)2.28442760
49Thrombocytosis (HP:0001894)2.28367463
50Multiple enchondromatosis (HP:0005701)2.27793473
51Secondary amenorrhea (HP:0000869)2.26337867
52Hypokinesia (HP:0002375)2.23438804
53Broad palm (HP:0001169)2.23052902
54Abnormality of reticulocytes (HP:0004312)2.22539776
55Upper limb muscle weakness (HP:0003484)2.21741704
56Hypochromic microcytic anemia (HP:0004840)2.21155694
57Testicular atrophy (HP:0000029)2.20684512
58Back pain (HP:0003418)2.20107145
59Abnormality of the distal phalanges of the toes (HP:0010182)2.19851654
60Distal lower limb amyotrophy (HP:0008944)2.17875559
61Long palpebral fissure (HP:0000637)2.15944378
62Aplasia/Hypoplasia of the patella (HP:0006498)2.14698857
63Myelodysplasia (HP:0002863)2.14058200
64Reduced antithrombin III activity (HP:0001976)2.13657978
65Abnormality of chromosome stability (HP:0003220)2.13131902
66Sparse eyelashes (HP:0000653)2.12604307
67Abnormality of cells of the erythroid lineage (HP:0012130)2.10377967
68Genu recurvatum (HP:0002816)2.10355067
69Biliary tract neoplasm (HP:0100574)2.10085365
70Heterotopia (HP:0002282)2.09702033
71Abnormal trabecular bone morphology (HP:0100671)2.09412236
72Fatigue (HP:0012378)2.08221727
73Long eyelashes (HP:0000527)2.06897082
74Neoplasm of the oral cavity (HP:0100649)2.06498782
75Abnormality of the Achilles tendon (HP:0005109)2.06274244
76Reticulocytopenia (HP:0001896)2.06250005
77Breast hypoplasia (HP:0003187)2.06115831
78Amaurosis fugax (HP:0100576)2.06056375
79Rectal prolapse (HP:0002035)2.04442427
80Renal duplication (HP:0000075)2.04270486
81Squamous cell carcinoma (HP:0002860)2.04052229
82Hypochromic anemia (HP:0001931)2.03983368
83Short nail (HP:0001799)2.02626232
84Abnormality of the fetal cardiovascular system (HP:0010948)2.02458072
85Abnormal umbilical cord blood vessels (HP:0011403)2.02458072
86Single umbilical artery (HP:0001195)2.02458072
87Abnormal number of erythroid precursors (HP:0012131)2.01278738
88Poikiloderma (HP:0001029)2.01103922
89Centrally nucleated skeletal muscle fibers (HP:0003687)2.00544395
90Shoulder girdle muscle weakness (HP:0003547)2.00410750
91Acanthocytosis (HP:0001927)1.99234047
92Atresia of the external auditory canal (HP:0000413)1.98101827
93Abnormal number of incisors (HP:0011064)1.97828347
94Gout (HP:0001997)1.97148401
95Fasciculations (HP:0002380)1.94981310
96Insidious onset (HP:0003587)1.94893976
97Termporal pattern (HP:0011008)1.94893976
98Progressive hearing impairment (HP:0001730)1.94191990
99Septate vagina (HP:0001153)1.94134077
100Glioma (HP:0009733)1.93850124
101Pelvic girdle muscle weakness (HP:0003749)1.92862416
102Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92839702
103Aplastic anemia (HP:0001915)1.92405855
104Malignant gastrointestinal tract tumors (HP:0006749)1.92382621
105Gastrointestinal carcinoma (HP:0002672)1.92382621
106Agnosia (HP:0010524)1.92201097
107Cutis marmorata (HP:0000965)1.91696960
108Entropion (HP:0000621)1.90889428
109Microretrognathia (HP:0000308)1.90667026
110Neoplasm of the pancreas (HP:0002894)1.89689478
111IgM deficiency (HP:0002850)1.88990377
112Skin tags (HP:0010609)1.88955987
113Overriding aorta (HP:0002623)1.84126127
114Orthostatic hypotension (HP:0001278)1.84011587
115Abnormality of the salivary glands (HP:0010286)1.82497273
116Glossoptosis (HP:0000162)1.82160737
117Fibroma (HP:0010614)1.81618824
118Sandal gap (HP:0001852)1.81045092
119Acute myeloid leukemia (HP:0004808)1.80990758
120Facial cleft (HP:0002006)1.80845795
121Natal tooth (HP:0000695)1.80491042
122Fibrous tissue neoplasm (HP:0012316)1.80358101
123Abnormalities of placenta or umbilical cord (HP:0001194)1.79966303
124Sparse lateral eyebrow (HP:0005338)1.79591756
125Type I transferrin isoform profile (HP:0003642)1.79565119
126Renovascular hypertension (HP:0100817)1.79348966
127Deep philtrum (HP:0002002)1.79280088
128Pseudobulbar signs (HP:0002200)1.79098115
129Abnormality of the phalanges of the hallux (HP:0010057)1.78848306
130Chromsome breakage (HP:0040012)1.78526388
131Abnormality of the 4th metacarpal (HP:0010012)1.78096518
132Abnormality of the lower motor neuron (HP:0002366)1.77906424
133Spastic diplegia (HP:0001264)1.77767269
134Unilateral renal agenesis (HP:0000122)1.77068022
135Achilles tendon contracture (HP:0001771)1.76979067
136Distal upper limb amyotrophy (HP:0007149)1.76230230
137Upper limb amyotrophy (HP:0009129)1.76230230
138Spinal rigidity (HP:0003306)1.75470677
139Intestinal polyp (HP:0005266)1.75077742
140Subacute progressive viral hepatitis (HP:0006572)1.74753453
141Atrophy/Degeneration involving motor neurons (HP:0007373)1.74094280
142Cortical dysplasia (HP:0002539)1.73470995
143Nonimmune hydrops fetalis (HP:0001790)1.72660327
144Onycholysis (HP:0001806)1.72608217
145Cutaneous melanoma (HP:0012056)1.72081761
146High anterior hairline (HP:0009890)1.71152933
147Upper motor neuron abnormality (HP:0002127)1.71018725
148Distal lower limb muscle weakness (HP:0009053)1.70581888
149Neoplasm of the small intestine (HP:0100833)1.70540961
150Carpal bone hypoplasia (HP:0001498)1.70472248
151Sacral dimple (HP:0000960)1.70367260
152Elfin facies (HP:0004428)1.70085027
153Abnormality of the preputium (HP:0100587)1.69860752
154Impulsivity (HP:0100710)1.67867369
155Abnormality of the calcaneus (HP:0008364)1.67754164
156Verrucae (HP:0200043)1.67714048
157Papilloma (HP:0012740)1.67714048
158Deep palmar crease (HP:0006191)1.67534752
159Death in infancy (HP:0001522)1.67519599
160Hand muscle atrophy (HP:0009130)1.67105959
161Reduced subcutaneous adipose tissue (HP:0003758)1.67039022
162Fragile nails (HP:0001808)1.66713751
163Ankyloglossia (HP:0010296)1.66305475
164Absent thumb (HP:0009777)1.66141713
165Neoplasm of the rectum (HP:0100743)1.65280317
166Microglossia (HP:0000171)1.65276762
167Autoamputation (HP:0001218)1.65202939
168Premature ovarian failure (HP:0008209)1.64240634
169Abnormality of the labia minora (HP:0012880)1.64233575
170Preauricular skin tag (HP:0000384)1.64203408
171Intestinal polyposis (HP:0200008)1.63319269
172Abnormal glycosylation (HP:0012345)1.63202270
173Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.63202270
174Abnormal protein N-linked glycosylation (HP:0012347)1.63202270
175Abnormal protein glycosylation (HP:0012346)1.63202270
176Patellar dislocation (HP:0002999)1.63055437
177Right ventricular cardiomyopathy (HP:0011663)1.62656567
178Increased connective tissue (HP:0009025)1.62651484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.20091101
2EEF2K3.81115738
3CDK123.55069806
4MAP3K103.18640492
5TRIB33.14798195
6SMG13.14020314
7PKN22.98233543
8VRK22.95227224
9NEK22.70492249
10WEE12.34874907
11STK102.27885944
12TESK12.21425045
13PBK1.90310820
14IRAK31.89339751
15SCYL21.89090382
16TTK1.88927165
17CDK41.85900219
18MAP4K11.83779788
19NEK11.80639986
20EIF2AK11.77671930
21BUB11.70333449
22MAP3K81.66738509
23ALK1.56500307
24STK31.53437315
25RPS6KA41.52489385
26PRPF4B1.50088282
27RPS6KB21.47626531
28EPHA21.43485281
29TAOK11.42321549
30ARAF1.40634029
31CDK71.39913242
32LRRK21.39833780
33LATS11.35613940
34LATS21.33094913
35ACVR1B1.30236805
36MST1R1.29439943
37CDK61.28248944
38BRSK21.23129866
39ATR1.22476065
40FLT31.22349543
41PLK11.21533356
42CHEK11.18543510
43AURKB1.17996758
44SIK31.16024092
45TSSK61.12238749
46TAOK21.11677921
47STK41.10888504
48MTOR1.07224361
49CHEK21.06559215
50GRK61.06552660
51DYRK31.05723163
52TESK21.03581953
53LIMK11.01548910
54PIM11.01500860
55ERN11.00732945
56BRSK10.99737942
57PASK0.99229833
58MAP2K30.98076439
59ZAP700.97280064
60SIK10.95674882
61NME10.94113354
62PAK40.93232878
63BRD40.92303786
64PTK60.91708065
65STK160.91157877
66TGFBR10.89354231
67MAP3K110.88930385
68JAK30.88867360
69DAPK10.86478316
70CDK20.86459839
71LMTK20.85175924
72TLK10.84583968
73SRPK10.83786060
74NME20.80526712
75ATM0.80284683
76CLK10.78652073
77ICK0.76747815
78MELK0.75694238
79PLK30.75589947
80ERBB40.75306906
81EIF2AK30.74537619
82PTK20.74374707
83TAF10.74236021
84BRAF0.73703347
85AURKA0.71667370
86FGFR40.70367824
87MET0.69852813
88CDK90.69318677
89MAPKAPK30.69021568
90RIPK10.67731951
91BMX0.65398469
92MAPK110.63978212
93PAK20.63778442
94RAF10.63667644
95PDGFRA0.62827994
96EPHB10.62680355
97KSR20.60456685
98MAP3K50.59523613
99EIF2AK20.55949983
100PLK40.55648876
101TTN0.54575831
102CDK10.52646403
103MAP3K60.51446848
104MST40.51311702
105PAK10.50662723
106BCKDK0.49336829
107CDK140.48822071
108CDK11A0.47207198
109RPS6KA10.46448089
110FGFR10.43975515
111AKT20.43849836
112BTK0.43255242
113MKNK10.43038766
114CDK150.42644009
115CDK180.42383452
116TYRO30.42167021
117CDK80.42166465
118CAMK1D0.42050705
119STK240.40599476
120PRKD30.40525515
121NTRK10.40326877
122MAP3K90.39327874
123CSNK1E0.38106633
124ILK0.37999772
125DMPK0.37265608
126CSNK1D0.37015093
127CSNK2A20.36949773
128RET0.35012130
129JAK20.33289635
130MAPK140.31976773
131PRKDC0.30459695
132CSNK2A10.30425883
133MAP3K70.29696894
134CHUK0.29462212
135PIM20.28713600
136TYK20.27424858
137KDR0.27373934

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.29555515
2Mismatch repair_Homo sapiens_hsa034303.22766558
3* Proteasome_Homo sapiens_hsa030503.09330838
4RNA transport_Homo sapiens_hsa030133.07812059
5Cell cycle_Homo sapiens_hsa041102.96629581
6One carbon pool by folate_Homo sapiens_hsa006702.91944144
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83858718
8Spliceosome_Homo sapiens_hsa030402.66789723
9Base excision repair_Homo sapiens_hsa034102.58053194
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19113581
11mRNA surveillance pathway_Homo sapiens_hsa030152.06130364
12Nucleotide excision repair_Homo sapiens_hsa034201.97038177
13Homologous recombination_Homo sapiens_hsa034401.96363238
14Chronic myeloid leukemia_Homo sapiens_hsa052201.56046369
15RNA degradation_Homo sapiens_hsa030181.54689414
16p53 signaling pathway_Homo sapiens_hsa041151.52146810
17Viral carcinogenesis_Homo sapiens_hsa052031.44494027
18RNA polymerase_Homo sapiens_hsa030201.35794309
19Ribosome_Homo sapiens_hsa030101.34073129
20Pyrimidine metabolism_Homo sapiens_hsa002401.32527522
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30288616
22Fanconi anemia pathway_Homo sapiens_hsa034601.29688740
23Thyroid cancer_Homo sapiens_hsa052161.28244459
24Non-homologous end-joining_Homo sapiens_hsa034501.26438643
25Systemic lupus erythematosus_Homo sapiens_hsa053221.23469029
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23112829
27Biosynthesis of amino acids_Homo sapiens_hsa012301.22654296
28mTOR signaling pathway_Homo sapiens_hsa041501.19035330
29Small cell lung cancer_Homo sapiens_hsa052221.18354967
30Herpes simplex infection_Homo sapiens_hsa051681.18259636
31HTLV-I infection_Homo sapiens_hsa051661.18193467
32MicroRNAs in cancer_Homo sapiens_hsa052061.17627349
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.17398385
34Oocyte meiosis_Homo sapiens_hsa041141.15690674
35Non-small cell lung cancer_Homo sapiens_hsa052231.12018867
36Epstein-Barr virus infection_Homo sapiens_hsa051691.11880445
37Galactose metabolism_Homo sapiens_hsa000521.11631566
38Selenocompound metabolism_Homo sapiens_hsa004501.11577413
39Fructose and mannose metabolism_Homo sapiens_hsa000511.08592731
40Colorectal cancer_Homo sapiens_hsa052101.05852558
41Folate biosynthesis_Homo sapiens_hsa007901.05621355
42Acute myeloid leukemia_Homo sapiens_hsa052211.05519730
43Fatty acid elongation_Homo sapiens_hsa000621.02771793
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02252113
45Bladder cancer_Homo sapiens_hsa052191.01268305
46Pyruvate metabolism_Homo sapiens_hsa006200.99547319
47Pancreatic cancer_Homo sapiens_hsa052120.99389332
48Pentose phosphate pathway_Homo sapiens_hsa000300.99312380
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.98506731
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97248778
51Lysine degradation_Homo sapiens_hsa003100.97210937
52N-Glycan biosynthesis_Homo sapiens_hsa005100.95993059
53Basal transcription factors_Homo sapiens_hsa030220.93990723
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.93098615
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91386024
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90565675
57Hepatitis B_Homo sapiens_hsa051610.89368159
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89168897
59Sulfur relay system_Homo sapiens_hsa041220.87599750
60* Antigen processing and presentation_Homo sapiens_hsa046120.84515039
61Apoptosis_Homo sapiens_hsa042100.83075949
62B cell receptor signaling pathway_Homo sapiens_hsa046620.81500917
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78282564
64Endometrial cancer_Homo sapiens_hsa052130.77977492
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77352376
66Primary immunodeficiency_Homo sapiens_hsa053400.77316714
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74308794
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.73556525
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72496087
70T cell receptor signaling pathway_Homo sapiens_hsa046600.72360289
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71038701
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69784356
73Notch signaling pathway_Homo sapiens_hsa043300.69186527
74VEGF signaling pathway_Homo sapiens_hsa043700.69093723
75Hippo signaling pathway_Homo sapiens_hsa043900.68995533
76Carbon metabolism_Homo sapiens_hsa012000.68121497
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67885026
78Shigellosis_Homo sapiens_hsa051310.66848046
79Adherens junction_Homo sapiens_hsa045200.65313953
80Viral myocarditis_Homo sapiens_hsa054160.65114443
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63978481
82Vibrio cholerae infection_Homo sapiens_hsa051100.63069540
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62244860
84Measles_Homo sapiens_hsa051620.62234477
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60869526
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60151539
87TGF-beta signaling pathway_Homo sapiens_hsa043500.59420898
88HIF-1 signaling pathway_Homo sapiens_hsa040660.58478987
89Proteoglycans in cancer_Homo sapiens_hsa052050.57686342
90Glioma_Homo sapiens_hsa052140.57624083
91Legionellosis_Homo sapiens_hsa051340.54883330
92Prostate cancer_Homo sapiens_hsa052150.54174425
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.53674543
94Steroid biosynthesis_Homo sapiens_hsa001000.53177845
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52852015
96Prolactin signaling pathway_Homo sapiens_hsa049170.52525492
97Glutathione metabolism_Homo sapiens_hsa004800.50565580
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50458698
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49458627
100AMPK signaling pathway_Homo sapiens_hsa041520.48556325
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48245527
102Phenylalanine metabolism_Homo sapiens_hsa003600.48061735
103Toxoplasmosis_Homo sapiens_hsa051450.47019493
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46076551
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44752382
106Alcoholism_Homo sapiens_hsa050340.44187695
107Nitrogen metabolism_Homo sapiens_hsa009100.43883657
108FoxO signaling pathway_Homo sapiens_hsa040680.43873089
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43006395
110Influenza A_Homo sapiens_hsa051640.42866215
111Leishmaniasis_Homo sapiens_hsa051400.42420853
112Vitamin B6 metabolism_Homo sapiens_hsa007500.41554726
113Insulin signaling pathway_Homo sapiens_hsa049100.40944104
114Insulin resistance_Homo sapiens_hsa049310.40839055
115Pathways in cancer_Homo sapiens_hsa052000.39562555
116Renal cell carcinoma_Homo sapiens_hsa052110.39371722
117Prion diseases_Homo sapiens_hsa050200.39363843
118Purine metabolism_Homo sapiens_hsa002300.38540460
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.37858643
120Arginine and proline metabolism_Homo sapiens_hsa003300.37330325
121Salmonella infection_Homo sapiens_hsa051320.35512121
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31825457
123Huntingtons disease_Homo sapiens_hsa050160.29920490
124Endocytosis_Homo sapiens_hsa041440.28208905
125Metabolic pathways_Homo sapiens_hsa011000.23342527
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21883423
127Fatty acid metabolism_Homo sapiens_hsa012120.21259383
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21023926
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20772227

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