PSME4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.78940118
2nuclear pore organization (GO:0006999)5.36330671
3mitotic sister chromatid cohesion (GO:0007064)4.35979833
4monoubiquitinated protein deubiquitination (GO:0035520)4.35836349
5pore complex assembly (GO:0046931)4.21420490
6fusion of sperm to egg plasma membrane (GO:0007342)3.77603071
7cilium or flagellum-dependent cell motility (GO:0001539)3.72013255
8embryonic process involved in female pregnancy (GO:0060136)3.62116443
9sperm-egg recognition (GO:0035036)3.58212012
10regulation of histone H3-K9 methylation (GO:0051570)3.56869159
11regulation of transforming growth factor beta2 production (GO:0032909)3.55681554
12male meiosis (GO:0007140)3.54495643
13synaptonemal complex assembly (GO:0007130)3.54225183
14binding of sperm to zona pellucida (GO:0007339)3.52922539
15COPII vesicle coating (GO:0048208)3.48582899
16regulation of protein polyubiquitination (GO:1902914)3.45039473
17paraxial mesoderm development (GO:0048339)3.44042964
18pre-miRNA processing (GO:0031054)3.43670236
19sperm motility (GO:0030317)3.42705377
20synaptonemal complex organization (GO:0070193)3.42270599
21DNA unwinding involved in DNA replication (GO:0006268)3.41428461
22mitotic chromosome condensation (GO:0007076)3.37645779
23piRNA metabolic process (GO:0034587)3.36912443
24regulation of histone H3-K27 methylation (GO:0061085)3.35773279
25negative regulation of DNA repair (GO:0045738)3.35546608
26regulation of RNA export from nucleus (GO:0046831)3.35374128
27NLS-bearing protein import into nucleus (GO:0006607)3.34948029
28acrosome assembly (GO:0001675)3.34771435
29carnitine shuttle (GO:0006853)3.32056510
30regulation of gene silencing by RNA (GO:0060966)3.29663228
31regulation of posttranscriptional gene silencing (GO:0060147)3.29663228
32regulation of gene silencing by miRNA (GO:0060964)3.29663228
33carnitine transmembrane transport (GO:1902603)3.27914449
34heterochromatin organization (GO:0070828)3.25524039
35DNA topological change (GO:0006265)3.24533134
36carnitine transport (GO:0015879)3.22693386
37amino-acid betaine transport (GO:0015838)3.22693386
38bundle of His cell to Purkinje myocyte communication (GO:0086069)3.20735040
39fatty acid transmembrane transport (GO:1902001)3.19102436
40gene silencing by RNA (GO:0031047)3.18559965
41regulation of hippo signaling (GO:0035330)3.17827124
42DNA duplex unwinding (GO:0032508)3.17731571
43cell-cell recognition (GO:0009988)3.16963669
44regulation of centriole replication (GO:0046599)3.16258583
45hemidesmosome assembly (GO:0031581)3.14072550
46negative regulation of histone methylation (GO:0031061)3.12992390
47chromosome condensation (GO:0030261)3.08219894
48mitotic nuclear envelope disassembly (GO:0007077)3.04999221
49cytoplasmic mRNA processing body assembly (GO:0033962)3.04940856
50DNA geometric change (GO:0032392)3.03348173
51spermatid development (GO:0007286)3.02679193
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.00996296
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00996296
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00996296
55chaperone-mediated protein complex assembly (GO:0051131)3.00197264
56genitalia morphogenesis (GO:0035112)2.98454720
57negative regulation of fatty acid biosynthetic process (GO:0045717)2.97920905
58histone H3-K9 demethylation (GO:0033169)2.94542390
59DNA replication-dependent nucleosome organization (GO:0034723)2.94422460
60DNA replication-dependent nucleosome assembly (GO:0006335)2.94422460
61ribosome assembly (GO:0042255)2.93954652
62multicellular organism reproduction (GO:0032504)2.93645130
63cellular protein complex localization (GO:0034629)2.92645108
64cell wall macromolecule catabolic process (GO:0016998)2.92051235
65cell wall macromolecule metabolic process (GO:0044036)2.92051235
66nuclear envelope disassembly (GO:0051081)2.91787024
67membrane disassembly (GO:0030397)2.91787024
68regulation of sister chromatid cohesion (GO:0007063)2.88285757
69chromatin assembly (GO:0031497)2.86536563
70negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.85730744
71DNA packaging (GO:0006323)2.84304431
72cell-substrate junction assembly (GO:0007044)2.83359456
73protein localization to chromosome, centromeric region (GO:0071459)2.82045988
74interkinetic nuclear migration (GO:0022027)2.81373750
75phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.80673356
76protein export from nucleus (GO:0006611)2.79860755
77lysine metabolic process (GO:0006553)2.79093603
78lysine catabolic process (GO:0006554)2.79093603
79DNA conformation change (GO:0071103)2.76626402
80UDP-N-acetylglucosamine metabolic process (GO:0006047)2.76321953
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.72136307
82regulation of stem cell maintenance (GO:2000036)2.71964541
83positive regulation of SMAD protein import into nucleus (GO:0060391)2.70392371
84positive regulation of protein import into nucleus, translocation (GO:0033160)2.70000217
85sister chromatid cohesion (GO:0007062)2.68269089
86histone H2A monoubiquitination (GO:0035518)2.67887277
87RNA stabilization (GO:0043489)2.67149743
88mRNA stabilization (GO:0048255)2.67149743
89mitotic metaphase plate congression (GO:0007080)2.67018127
90protein localization to kinetochore (GO:0034501)2.65733682
91iron ion import (GO:0097286)2.65259431
92gene silencing (GO:0016458)2.64229646
93folic acid-containing compound biosynthetic process (GO:0009396)2.63686190
94mesodermal cell differentiation (GO:0048333)2.63385391
95nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.62064329
96definitive hemopoiesis (GO:0060216)2.61902904
97sister chromatid segregation (GO:0000819)2.60560300
98negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.60196379
99histone H3-K36 demethylation (GO:0070544)2.59896418
100motile cilium assembly (GO:0044458)2.59128190
101focal adhesion assembly (GO:0048041)2.59088964
102cell-substrate adherens junction assembly (GO:0007045)2.59088964
103plasma membrane fusion (GO:0045026)2.58779848
104desmosome organization (GO:0002934)2.58460962
105chromosome organization involved in meiosis (GO:0070192)2.57513604
106regulation of nucleobase-containing compound transport (GO:0032239)2.54154923
107reproduction (GO:0000003)2.52671468
108positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52503040
109protein localization to microtubule (GO:0035372)2.52213585
110positive regulation of chromosome segregation (GO:0051984)2.49802729
111regulation of translational fidelity (GO:0006450)2.49499613
112N-terminal protein amino acid acetylation (GO:0006474)2.49484413
113homocysteine metabolic process (GO:0050667)2.48341508
114regulation of spindle organization (GO:0090224)2.48327846
115protein complex localization (GO:0031503)2.48177848
116hypotonic response (GO:0006971)2.47060317
117hippo signaling (GO:0035329)2.46163886
118negative regulation of fibroblast apoptotic process (GO:2000270)2.46063825
119adherens junction assembly (GO:0034333)2.45576929
120negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.44770207
121mitotic G2/M transition checkpoint (GO:0044818)2.43614393
122COPI coating of Golgi vesicle (GO:0048205)2.43255354
123Golgi transport vesicle coating (GO:0048200)2.43255354
124meiotic nuclear division (GO:0007126)2.43112328
125anterior/posterior axis specification, embryo (GO:0008595)2.42218638
126male meiosis I (GO:0007141)2.41907481
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.41837962
128regulation of centrosome cycle (GO:0046605)2.41361173
129trophectodermal cell differentiation (GO:0001829)2.40011739
130positive regulation of catenin import into nucleus (GO:0035413)2.39785214
131positive regulation of fatty acid beta-oxidation (GO:0032000)2.39352979
132metaphase plate congression (GO:0051310)2.39350740
133regulation of mitotic spindle organization (GO:0060236)2.39310868
134peptidyl-lysine dimethylation (GO:0018027)2.38674352
135cell adhesion mediated by integrin (GO:0033627)2.38255092
136microtubule depolymerization (GO:0007019)2.38221438
137intracellular lipid transport (GO:0032365)2.38185839
138regulation of DNA damage checkpoint (GO:2000001)2.37855764
139protein K6-linked ubiquitination (GO:0085020)2.37472875
140axonemal dynein complex assembly (GO:0070286)2.36639453
141regulation of translational termination (GO:0006449)2.36063668
142regulation of SMAD protein import into nucleus (GO:0060390)2.35858440
143mitotic sister chromatid segregation (GO:0000070)2.35483736
144nuclear envelope organization (GO:0006998)2.34804519
145DNA replication initiation (GO:0006270)2.32380283
146regulation of establishment of cell polarity (GO:2000114)2.31421337
147regulation of centrosome duplication (GO:0010824)2.30494470
148nodal signaling pathway (GO:0038092)2.30390642
149negative regulation of potassium ion transmembrane transport (GO:1901380)2.30196914
150spliceosomal tri-snRNP complex assembly (GO:0000244)2.28601938
151protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.28370682
152notochord development (GO:0030903)2.26572636
1533-UTR-mediated mRNA stabilization (GO:0070935)2.24551890
154glucocorticoid receptor signaling pathway (GO:0042921)2.24500956
155histone lysine demethylation (GO:0070076)2.22897695
156non-recombinational repair (GO:0000726)2.22474356
157double-strand break repair via nonhomologous end joining (GO:0006303)2.22474356
158hepatocyte apoptotic process (GO:0097284)2.20742741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.72478655
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.59403123
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.49035900
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.66938386
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12013618
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.11619941
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.96890265
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51988823
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45445153
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.43837526
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.35206163
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33513580
13AR_21909140_ChIP-Seq_LNCAP_Human2.29949096
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.27094329
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.22805015
16GATA1_22025678_ChIP-Seq_K562_Human2.20267140
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19539113
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.16393954
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15653014
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14320179
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.03122256
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.00087119
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.95692222
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.87585458
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84594630
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78335327
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76772465
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66312393
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63966102
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.62642787
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.60828258
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58057699
33ZNF263_19887448_ChIP-Seq_K562_Human1.56862167
34CLOCK_20551151_ChIP-Seq_293T_Human1.55721508
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.55501520
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54823411
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54321813
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.53136935
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51293049
40MYC_22102868_ChIP-Seq_BL_Human1.50688773
41* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49780692
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47494158
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43665622
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39179400
45TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38144621
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34987292
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34661646
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33155753
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32422748
50NANOG_21062744_ChIP-ChIP_HESCs_Human1.30476005
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29494372
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29494372
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29494372
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27033864
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24332673
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21112061
57EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20533021
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19824859
59* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19802116
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19561043
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17612087
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17584390
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.16299393
64NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15543432
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13839760
66* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13784526
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12568042
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12270719
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11983745
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10657009
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10502161
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09763228
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09341333
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08863103
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07826740
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07317278
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07098468
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05942375
79TCF7_22412390_ChIP-Seq_EML_Mouse1.05640116
80GATA6_25053715_ChIP-Seq_YYC3_Human1.05513655
81GATA2_19941826_ChIP-Seq_K562_Human1.05163642
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04909723
83* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04093652
84GATA1_19941826_ChIP-Seq_K562_Human1.03408485
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02703391
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02276215
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.01864436
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.01864436
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.01580035
90ESR1_21235772_ChIP-Seq_MCF-7_Human0.99605444
91* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99378822
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.98976537
93GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98147808
94TFEB_21752829_ChIP-Seq_HELA_Human0.98020660
95* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97726203
96CHD1_26751641_Chip-Seq_LNCaP_Human0.96083186
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95732905
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93993959
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93379668
100UBF1/2_26484160_Chip-Seq_HMECs_Human0.93314935
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93235583
102SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92303971
103P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92251905
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92091871
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.91643899
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.91516901
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91412257
108* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91369185
109NCOR1_26117541_ChIP-Seq_K562_Human0.91353312
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91042838
111* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91019533
112TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90553697
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90243817
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.89416706
115FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89025654
116* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88599102
117NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88371301
118TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88272206
119ELK1_19687146_ChIP-ChIP_HELA_Human0.87837465
120MYC_18555785_ChIP-Seq_MESCs_Mouse0.87451492
121SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87325443
122BRD4_25478319_ChIP-Seq_HGPS_Human0.85608562
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85494124
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84716536
125MYC_19030024_ChIP-ChIP_MESCs_Mouse0.83730499
126KDM5A_27292631_Chip-Seq_BREAST_Human0.83396614
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82178522
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81652414
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81468362
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80755424
131* ATF3_27146783_Chip-Seq_COLON_Human0.80538731
132* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80018142
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79627019
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79388031
135MYC_19079543_ChIP-ChIP_MESCs_Mouse0.79338794
136TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79084229
137SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79019156
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79019156
139* NANOG_16518401_ChIP-PET_MESCs_Mouse0.78801282
140PKCTHETA_26484144_Chip-Seq_BREAST_Human0.77775298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.15947763
2MP0005410_abnormal_fertilization2.90428715
3MP0003806_abnormal_nucleotide_metabolis2.44198253
4MP0005451_abnormal_body_composition2.36823931
5MP0002139_abnormal_hepatobiliary_system2.30778939
6MP0010352_gastrointestinal_tract_polyps2.22559342
7MP0003646_muscle_fatigue2.08381626
8MP0005360_urolithiasis2.05620530
9MP0009697_abnormal_copulation1.96695885
10MP0010307_abnormal_tumor_latency1.95268725
11MP0005085_abnormal_gallbladder_physiolo1.92628966
12MP0005365_abnormal_bile_salt1.86713124
13MP0010094_abnormal_chromosome_stability1.84479017
14MP0004272_abnormal_basement_membrane1.79846417
15MP0005076_abnormal_cell_differentiation1.79657128
16MP0001661_extended_life_span1.76277023
17MP0004084_abnormal_cardiac_muscle1.69211366
18MP0002009_preneoplasia1.68066282
19MP0002837_dystrophic_cardiac_calcinosis1.67483718
20MP0003111_abnormal_nucleus_morphology1.65617272
21MP0003252_abnormal_bile_duct1.64346114
22MP0010234_abnormal_vibrissa_follicle1.62226281
23MP0008057_abnormal_DNA_replication1.59605953
24MP0005666_abnormal_adipose_tissue1.58245208
25MP0003656_abnormal_erythrocyte_physiolo1.57039730
26MP0002877_abnormal_melanocyte_morpholog1.56801902
27MP0001730_embryonic_growth_arrest1.56241102
28MP0002396_abnormal_hematopoietic_system1.55758080
29MP0004264_abnormal_extraembryonic_tissu1.54047076
30MP0003077_abnormal_cell_cycle1.53401665
31MP0004185_abnormal_adipocyte_glucose1.52768833
32MP0004808_abnormal_hematopoietic_stem1.52571487
33MP0005380_embryogenesis_phenotype1.51309403
34MP0001672_abnormal_embryogenesis/_devel1.51309403
35MP0008877_abnormal_DNA_methylation1.50084724
36MP0002269_muscular_atrophy1.49613937
37MP0004197_abnormal_fetal_growth/weight/1.48047089
38MP0004233_abnormal_muscle_weight1.47465238
39* MP0001929_abnormal_gametogenesis1.46902195
40MP0003984_embryonic_growth_retardation1.45184538
41MP0004087_abnormal_muscle_fiber1.45025968
42MP0010630_abnormal_cardiac_muscle1.44192031
43MP0002088_abnormal_embryonic_growth/wei1.44022208
44MP0002084_abnormal_developmental_patter1.42278391
45MP0003890_abnormal_embryonic-extraembry1.40880609
46MP0009053_abnormal_anal_canal1.40483026
47MP0004957_abnormal_blastocyst_morpholog1.40054683
48MP0004130_abnormal_muscle_cell1.35963932
49MP0000733_abnormal_muscle_development1.33056120
50MP0002653_abnormal_ependyma_morphology1.32798194
51MP0003091_abnormal_cell_migration1.31766922
52MP0002086_abnormal_extraembryonic_tissu1.31079812
53MP0002254_reproductive_system_inflammat1.30583848
54MP0008932_abnormal_embryonic_tissue1.28875135
55MP0003566_abnormal_cell_adhesion1.28723521
56MP0003828_pulmonary_edema1.27766131
57MP0005670_abnormal_white_adipose1.26021780
58MP0003693_abnormal_embryo_hatching1.24619430
59MP0008007_abnormal_cellular_replicative1.24231008
60MP0004036_abnormal_muscle_relaxation1.24077366
61* MP0003698_abnormal_male_reproductive1.23506839
62MP0001697_abnormal_embryo_size1.23328190
63MP0000537_abnormal_urethra_morphology1.22744929
64MP0002166_altered_tumor_susceptibility1.21869671
65MP0003950_abnormal_plasma_membrane1.21042736
66MP0002085_abnormal_embryonic_tissue1.20430320
67MP0002210_abnormal_sex_determination1.19046952
68MP0001849_ear_inflammation1.19044854
69MP0003453_abnormal_keratinocyte_physiol1.18436049
70MP0003567_abnormal_fetal_cardiomyocyte1.18256276
71MP0006138_congestive_heart_failure1.17020111
72MP0009672_abnormal_birth_weight1.16234628
73MP0002060_abnormal_skin_morphology1.15892313
74MP0000350_abnormal_cell_proliferation1.15170857
75MP0005621_abnormal_cell_physiology1.13172740
76MP0005409_darkened_coat_color1.13158811
77MP0003123_paternal_imprinting1.10505838
78MP0010678_abnormal_skin_adnexa1.09179458
79MP0000749_muscle_degeneration1.06460177
80MP0005330_cardiomyopathy1.04435038
81MP0001145_abnormal_male_reproductive1.03756906
82MP0000751_myopathy1.02786656
83MP0000750_abnormal_muscle_regeneration1.02027992
84MP0005248_abnormal_Harderian_gland1.01363516
85MP0001216_abnormal_epidermal_layer1.01152876
86MP0003937_abnormal_limbs/digits/tail_de1.00901766
87MP0000428_abnormal_craniofacial_morphol0.99052950
88MP0001293_anophthalmia0.98794281
89MP0009703_decreased_birth_body0.98070391
90MP0003221_abnormal_cardiomyocyte_apopto0.98033728
91MP0010030_abnormal_orbit_morphology0.96901036
92MP0002006_tumorigenesis0.96892303
93MP0008775_abnormal_heart_ventricle0.96497269
94MP0003943_abnormal_hepatobiliary_system0.96484616
95MP0002080_prenatal_lethality0.94675561
96MP0000266_abnormal_heart_morphology0.93991906
97MP0000579_abnormal_nail_morphology0.93895933
98MP0004215_abnormal_myocardial_fiber0.93781786
99MP0002106_abnormal_muscle_physiology0.93336772
100MP0000653_abnormal_sex_gland0.91251554
101MP0005623_abnormal_meninges_morphology0.91219322
102MP0005375_adipose_tissue_phenotype0.88513720
103MP0010329_abnormal_lipoprotein_level0.88454931
104MP0008438_abnormal_cutaneous_collagen0.88022505
105MP0000627_abnormal_mammary_gland0.87928054
106MP0002697_abnormal_eye_size0.87658966
107MP0002796_impaired_skin_barrier0.86825422
108MP0008875_abnormal_xenobiotic_pharmacok0.86690793
109MP0008058_abnormal_DNA_repair0.86349338
110MP0010368_abnormal_lymphatic_system0.85329480
111MP0005384_cellular_phenotype0.84865565
112MP0000383_abnormal_hair_follicle0.83767349
113MP0004145_abnormal_muscle_electrophysio0.83409426
114MP0000762_abnormal_tongue_morphology0.83350212
115MP0001915_intracranial_hemorrhage0.82912200
116MP0005275_abnormal_skin_tensile0.82456798
117MP0000609_abnormal_liver_physiology0.82450821
118MP0002925_abnormal_cardiovascular_devel0.82312881
119MP0003786_premature_aging0.81595585
120MP0000759_abnormal_skeletal_muscle0.80890282
121* MP0002161_abnormal_fertility/fecundity0.79950806
122MP0005620_abnormal_muscle_contractility0.79829381
123MP0002128_abnormal_blood_circulation0.79372471
124MP0000569_abnormal_digit_pigmentation0.78600708
125MP0005187_abnormal_penis_morphology0.77856716
126MP0003119_abnormal_digestive_system0.77792500
127MP0000747_muscle_weakness0.77712459
128MP0001544_abnormal_cardiovascular_syste0.77303854
129MP0005385_cardiovascular_system_phenoty0.77303854
130MP0002092_abnormal_eye_morphology0.76478824
131MP0003935_abnormal_craniofacial_develop0.76293771
132MP0003941_abnormal_skin_development0.76286775
133MP0000313_abnormal_cell_death0.76138907
134MP0005023_abnormal_wound_healing0.76016598
135MP0003300_gastrointestinal_ulcer0.75630526
136MP0005408_hypopigmentation0.74390208
137MP0003763_abnormal_thymus_physiology0.73876600
138MP0000377_abnormal_hair_follicle0.73116171
139MP0001299_abnormal_eye_distance/0.71554601
140MP0001191_abnormal_skin_condition0.70653927
141MP0000432_abnormal_head_morphology0.70537628
142MP0002972_abnormal_cardiac_muscle0.70496323
143MP0002108_abnormal_muscle_morphology0.69466020

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.85758099
2Exercise-induced muscle cramps (HP:0003710)3.83273990
3Ankyloglossia (HP:0010296)3.27348720
4Hyporeflexia of lower limbs (HP:0002600)3.22504038
5Myoglobinuria (HP:0002913)3.19327803
6Right ventricular cardiomyopathy (HP:0011663)3.11883432
7Ependymoma (HP:0002888)3.06381331
8Increased connective tissue (HP:0009025)2.87453228
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83376093
10Acute myeloid leukemia (HP:0004808)2.81046229
11Chromsome breakage (HP:0040012)2.80698542
12Exercise-induced myalgia (HP:0003738)2.75379896
13Nemaline bodies (HP:0003798)2.74414041
14Rhabdomyolysis (HP:0003201)2.73615018
15Biliary tract neoplasm (HP:0100574)2.71249483
16Hypoplastic ischia (HP:0003175)2.70758304
17Dynein arm defect of respiratory motile cilia (HP:0012255)2.69865925
18Absent/shortened dynein arms (HP:0200106)2.69865925
19Intrahepatic cholestasis (HP:0001406)2.69413125
20Hypoalphalipoproteinemia (HP:0003233)2.69283511
21Papillary thyroid carcinoma (HP:0002895)2.67425823
22Abnormality of oral frenula (HP:0000190)2.64013226
23Hypoglycemic coma (HP:0001325)2.59725648
24Difficulty running (HP:0009046)2.55328351
25Deep philtrum (HP:0002002)2.52980015
26Abnormality of the astrocytes (HP:0100707)2.47740334
27Astrocytoma (HP:0009592)2.47740334
28Hyperglycemia (HP:0003074)2.46625026
29Cortical dysplasia (HP:0002539)2.43527654
30Abnormality of the ischium (HP:0003174)2.41607992
31Ventricular tachycardia (HP:0004756)2.38756999
32Relative macrocephaly (HP:0004482)2.37953816
33Impulsivity (HP:0100710)2.37496894
34Abnormality of the fingertips (HP:0001211)2.37460074
35Heterotopia (HP:0002282)2.37311788
36Chronic bronchitis (HP:0004469)2.36529927
37Muscle fiber splitting (HP:0003555)2.27776372
38Anal stenosis (HP:0002025)2.27717357
39Abnormality of the lower motor neuron (HP:0002366)2.27485432
40Calf muscle hypertrophy (HP:0008981)2.26762910
41Flat acetabular roof (HP:0003180)2.25663722
42Abnormality of the nasal septum (HP:0000419)2.24158078
43Nephroblastoma (Wilms tumor) (HP:0002667)2.19552468
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18561243
45Male infertility (HP:0003251)2.18063238
46Hypolipoproteinemia (HP:0010981)2.16712015
47Hypoplastic labia majora (HP:0000059)2.13251002
48Arterial tortuosity (HP:0005116)2.13212466
49Metaphyseal cupping (HP:0003021)2.11334407
50Epidermoid cyst (HP:0200040)2.11002789
51Abnormality of the left ventricular outflow tract (HP:0011103)2.10700385
52Subaortic stenosis (HP:0001682)2.10700385
53Sudden death (HP:0001699)2.10546081
54Embryonal renal neoplasm (HP:0011794)2.09755412
55Long eyelashes (HP:0000527)2.08532516
56Dysmetric saccades (HP:0000641)2.07729453
57Deep venous thrombosis (HP:0002625)2.07174267
58Curly hair (HP:0002212)2.07130832
59Muscle hypertrophy of the lower extremities (HP:0008968)2.05972143
60Abnormal respiratory motile cilium physiology (HP:0012261)2.05752628
61Difficulty climbing stairs (HP:0003551)2.05619903
62Asymmetry of the thorax (HP:0001555)2.05277832
63Hypochromic microcytic anemia (HP:0004840)2.01651860
64Short 4th metacarpal (HP:0010044)2.01371483
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01371483
66Hyperinsulinemic hypoglycemia (HP:0000825)2.01199140
67Ulnar deviation of the wrist (HP:0003049)1.99273040
68Skull defect (HP:0001362)1.97515169
69Abnormality of the 4th metacarpal (HP:0010012)1.96447009
70Abnormality of the labia majora (HP:0012881)1.95075400
71Acanthocytosis (HP:0001927)1.94925160
72Infertility (HP:0000789)1.94846327
73Short humerus (HP:0005792)1.94178178
74Glioma (HP:0009733)1.91943278
75Upper motor neuron abnormality (HP:0002127)1.91915456
76Dislocated radial head (HP:0003083)1.91607391
77Rhabdomyosarcoma (HP:0002859)1.90489082
78Volvulus (HP:0002580)1.88107561
79Neoplasm of the oral cavity (HP:0100649)1.88000024
80Abnormal biliary tract morphology (HP:0012440)1.87790961
81Sparse lateral eyebrow (HP:0005338)1.85786343
82Abnormality of sulfur amino acid metabolism (HP:0004339)1.85519539
83Short chin (HP:0000331)1.85514075
84EMG: neuropathic changes (HP:0003445)1.85021488
85Abnormal foot bone ossification (HP:0010675)1.84988847
86Insulin-resistant diabetes mellitus (HP:0000831)1.84699671
87Hyperglycinuria (HP:0003108)1.84494175
88Spastic diplegia (HP:0001264)1.84312486
89Breast carcinoma (HP:0003002)1.83569871
90Spinal cord lesions (HP:0100561)1.83434378
91Syringomyelia (HP:0003396)1.83434378
92Muscle fiber inclusion bodies (HP:0100299)1.83342613
93Abnormality of the salivary glands (HP:0010286)1.82810578
94Chin dimple (HP:0010751)1.82322015
95Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.81057269
96Lymphangioma (HP:0100764)1.81006051
97Narrow palate (HP:0000189)1.80890300
98Back pain (HP:0003418)1.80810412
99Abnormality of nail color (HP:0100643)1.80797624
100Deep palmar crease (HP:0006191)1.80637649
101Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80306615
102Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.80158409
103Subacute progressive viral hepatitis (HP:0006572)1.79775877
104Abnormality of lateral ventricle (HP:0030047)1.79501084
105Hyperkalemia (HP:0002153)1.79024101
106Deviation of the thumb (HP:0009603)1.77621694
107Neoplasm of the small intestine (HP:0100833)1.77588716
108Ketosis (HP:0001946)1.76639337
109Milia (HP:0001056)1.76504321
110Poikilocytosis (HP:0004447)1.76338340
111Truncal obesity (HP:0001956)1.75959641
112Prominent nose (HP:0000448)1.75890172
113Vascular tortuosity (HP:0004948)1.75121470
114Lipoatrophy (HP:0100578)1.75117255
115Neoplasm of striated muscle (HP:0009728)1.74776440
116Advanced eruption of teeth (HP:0006288)1.74445942
117Rectal prolapse (HP:0002035)1.74288197
118Rhinitis (HP:0012384)1.74190985
119Hepatocellular carcinoma (HP:0001402)1.74064560
120Medulloblastoma (HP:0002885)1.73456513
121Gastrointestinal carcinoma (HP:0002672)1.72011243
122Malignant gastrointestinal tract tumors (HP:0006749)1.72011243
123Asymmetric septal hypertrophy (HP:0001670)1.71452359
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70471044
125Type 1 muscle fiber predominance (HP:0003803)1.69590281
126Osteolytic defects of the hand bones (HP:0009699)1.69401472
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.69401472
128Missing ribs (HP:0000921)1.68942076
129Overgrowth (HP:0001548)1.68000628
130Bundle branch block (HP:0011710)1.67831192
131Distal arthrogryposis (HP:0005684)1.67748833
132Abnormality of the calf musculature (HP:0001430)1.67581789
133Sandal gap (HP:0001852)1.66797587
134Xanthomatosis (HP:0000991)1.66696458
135Abnormality of the radial head (HP:0003995)1.66657537
136Short middle phalanx of the 5th finger (HP:0004220)1.66269872
137Hyperammonemia (HP:0001987)1.65728711
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65603039
139Aortic aneurysm (HP:0004942)1.64753639
140Selective tooth agenesis (HP:0001592)1.64367711
141Centrally nucleated skeletal muscle fibers (HP:0003687)1.64359252
142Abnormality of the renal cortex (HP:0011035)1.63765792
143Aplasia/hypoplasia of the humerus (HP:0006507)1.63617329
144Hyperuricemia (HP:0002149)1.63435876
145Increased purine levels (HP:0004368)1.63435876
146Uterine neoplasm (HP:0010784)1.63326423
147Broad alveolar ridges (HP:0000187)1.62550586
148Hypopigmentation of the fundus (HP:0007894)1.62390339
149Ovarian neoplasm (HP:0100615)1.61377993
150Cafe-au-lait spot (HP:0000957)1.61029871
151Abnormality of the parathyroid morphology (HP:0011766)1.60699764
152Neoplasm of the rectum (HP:0100743)1.60686362
153Limited elbow extension (HP:0001377)1.59765345
154Overlapping toe (HP:0001845)1.59588597
15511 pairs of ribs (HP:0000878)1.58260399
156Lip pit (HP:0100267)1.57181007
157Atrophic scars (HP:0001075)1.56561623
158Mitral valve prolapse (HP:0001634)1.55557398
159Disproportionate tall stature (HP:0001519)1.55273603
160Progressive muscle weakness (HP:0003323)1.55139570
161Obsessive-compulsive behavior (HP:0000722)1.54353388
162Protrusio acetabuli (HP:0003179)1.52306945
163Premature rupture of membranes (HP:0001788)1.52224666
164Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.51873789
165Uterine leiomyosarcoma (HP:0002891)1.51775262
166Leiomyosarcoma (HP:0100243)1.51775262
167Cubitus valgus (HP:0002967)1.51462647
168Abnormality of the distal phalanx of the thumb (HP:0009617)1.49808870
169Natal tooth (HP:0000695)1.48890196
170Abnormality of the epiphyses of the hand (HP:0005924)1.47488032
171Areflexia of lower limbs (HP:0002522)1.46808620
172Bladder carcinoma (HP:0002862)1.46651063
173Bladder neoplasm (HP:0009725)1.46651063

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.49654084
2PDK44.49654084
3LATS13.81155521
4CDK123.04909715
5PDK23.01293690
6TTN2.65044689
7STK38L2.55131317
8CDC72.20994879
9PKN22.20275029
10NEK22.03329247
11STK32.01476757
12NEK11.96145899
13EIF2AK11.89913633
14TTK1.87619747
15TRIB31.81032691
16ICK1.74164835
17EEF2K1.71192440
18OBSCN1.68680277
19PBK1.58313435
20MKNK21.56501471
21EIF2AK31.49587562
22MAP3K101.47011289
23LATS21.44385327
24MST41.40180561
25FRK1.31794940
26PRKD31.30641751
27CDK61.26164911
28EPHA21.24561975
29MTOR1.21006970
30MKNK11.16829274
31PDGFRA1.16628972
32PRPF4B1.16503818
33SGK31.14207709
34ERBB41.13043105
35CAMK1D1.10682679
36SMG11.10469638
37TSSK61.08797858
38STK41.08564188
39PASK1.06430814
40MST1R1.06111209
41TESK11.05953585
42RIPK11.05375007
43MAP3K141.04772043
44FLT31.04329762
45BCKDK1.04134386
46CDK41.02851138
47KSR21.01068423
48PTK60.98967490
49CHEK10.97783703
50ZAK0.97509940
51RPS6KB20.97254157
52MET0.96555768
53WEE10.96256968
54NEK90.96019733
55KSR10.93190372
56CHEK20.91643117
57ATR0.90167900
58ATM0.89955561
59NLK0.88027573
60INSRR0.86933259
61PIK3CG0.85674368
62MELK0.85485231
63CLK10.85247575
64MAP3K20.84268600
65SIK10.83675764
66IRAK30.83507317
67BRD40.83289604
68PRKAA10.83084949
69PTK20.82270430
70AURKB0.82088810
71SGK20.80182138
72DMPK0.79996024
73PLK10.78428185
74STK380.78296092
75STK100.77586755
76CAMK1G0.76129838
77SCYL20.76054306
78DYRK30.72623804
79PLK40.69959146
80MAP3K80.69663104
81WNK10.68797766
82PDGFRB0.66295453
83FGFR20.65300293
84MAP2K30.64843030
85MAP3K50.64332334
86FGFR30.64032259
87MAP3K60.63911072
88MAP3K30.63878334
89NEK60.62963498
90SRPK10.61820925
91WNK40.61747144
92DYRK1B0.61508878
93FGFR40.60335517
94CSNK1D0.59774687
95PRKAA20.58505861
96RAF10.58126426
97PNCK0.57836249
98PIK3CA0.54583963
99MAP2K10.54343299
100BRSK20.53864103
101FGFR10.53811920
102CDK70.53702380
103CDK20.52721466
104AKT30.51914287
105TGFBR10.51351691
106MAP3K130.50768376
107BMX0.50711238
108CDK90.50403625
109PIM10.50210824
110LMTK20.48671117
111YES10.48629463
112TGFBR20.48059969
113PLK30.47788702
114NUAK10.46441014
115PAK20.46353028
116ALK0.45269617
117MAP3K70.43921242
118TRPM70.43312807
119CDK10.41918556
120TYRO30.41892258
121DDR20.39625907
122RPS6KB10.38785267
123TAF10.37685405
124STK240.37663108
125ACVR1B0.37569973
126MAPK110.37413579
127RET0.37215236
128RPS6KA40.37004234
129PAK40.36836606

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006402.69394703
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55273259
3Fatty acid degradation_Homo sapiens_hsa000712.42340583
4Selenocompound metabolism_Homo sapiens_hsa004502.41173037
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18960307
6Chronic myeloid leukemia_Homo sapiens_hsa052202.17283447
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16229167
8Thyroid cancer_Homo sapiens_hsa052162.05785672
9Pyruvate metabolism_Homo sapiens_hsa006201.96763572
10Nitrogen metabolism_Homo sapiens_hsa009101.95688495
11Carbon metabolism_Homo sapiens_hsa012001.90879469
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.88890343
13Non-small cell lung cancer_Homo sapiens_hsa052231.88862064
14One carbon pool by folate_Homo sapiens_hsa006701.87720533
15Lysine degradation_Homo sapiens_hsa003101.85969236
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83103527
17Pancreatic cancer_Homo sapiens_hsa052121.77302671
18Arginine biosynthesis_Homo sapiens_hsa002201.75577410
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74830357
20Fatty acid metabolism_Homo sapiens_hsa012121.74443903
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71448054
22Biosynthesis of amino acids_Homo sapiens_hsa012301.70616424
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.68515209
24Endometrial cancer_Homo sapiens_hsa052131.61932512
25PPAR signaling pathway_Homo sapiens_hsa033201.59950912
26Acute myeloid leukemia_Homo sapiens_hsa052211.58140430
27Tryptophan metabolism_Homo sapiens_hsa003801.50999415
28RNA transport_Homo sapiens_hsa030131.47703266
29Renal cell carcinoma_Homo sapiens_hsa052111.44344181
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43782782
31Bladder cancer_Homo sapiens_hsa052191.41776270
32Fatty acid biosynthesis_Homo sapiens_hsa000611.36879736
33Cell cycle_Homo sapiens_hsa041101.32702724
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.31651628
35Colorectal cancer_Homo sapiens_hsa052101.31532329
36Adherens junction_Homo sapiens_hsa045201.28843586
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27419520
38Nucleotide excision repair_Homo sapiens_hsa034201.26135188
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25297226
40Vitamin B6 metabolism_Homo sapiens_hsa007501.24234281
41Glucagon signaling pathway_Homo sapiens_hsa049221.22993971
42Insulin resistance_Homo sapiens_hsa049311.22759947
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20069988
44DNA replication_Homo sapiens_hsa030301.18432824
45ErbB signaling pathway_Homo sapiens_hsa040121.17976178
46Glioma_Homo sapiens_hsa052141.17823919
47mRNA surveillance pathway_Homo sapiens_hsa030151.17189249
48Systemic lupus erythematosus_Homo sapiens_hsa053221.13320676
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10834416
50Starch and sucrose metabolism_Homo sapiens_hsa005001.09667680
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08590312
52Complement and coagulation cascades_Homo sapiens_hsa046101.08544738
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03026312
54AMPK signaling pathway_Homo sapiens_hsa041521.01717362
55Prolactin signaling pathway_Homo sapiens_hsa049171.00715867
56Hepatitis B_Homo sapiens_hsa051611.00016528
57B cell receptor signaling pathway_Homo sapiens_hsa046620.99233415
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99167199
59Pentose phosphate pathway_Homo sapiens_hsa000300.96772061
60Fanconi anemia pathway_Homo sapiens_hsa034600.94757760
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93871128
62Fat digestion and absorption_Homo sapiens_hsa049750.93426330
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.92819284
64Butanoate metabolism_Homo sapiens_hsa006500.92130713
65Circadian rhythm_Homo sapiens_hsa047100.90948199
66Inositol phosphate metabolism_Homo sapiens_hsa005620.90273816
67Melanoma_Homo sapiens_hsa052180.90053347
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88965818
69MicroRNAs in cancer_Homo sapiens_hsa052060.88052335
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87812820
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87712794
72mTOR signaling pathway_Homo sapiens_hsa041500.87189679
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87033981
74Peroxisome_Homo sapiens_hsa041460.86639320
75TGF-beta signaling pathway_Homo sapiens_hsa043500.86565499
76RNA degradation_Homo sapiens_hsa030180.85752381
77VEGF signaling pathway_Homo sapiens_hsa043700.85569376
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82443418
79Amoebiasis_Homo sapiens_hsa051460.81253503
80HIF-1 signaling pathway_Homo sapiens_hsa040660.81154655
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80610618
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80428588
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79755298
84Small cell lung cancer_Homo sapiens_hsa052220.79510018
85Chemical carcinogenesis_Homo sapiens_hsa052040.78941530
86Hippo signaling pathway_Homo sapiens_hsa043900.78454978
87beta-Alanine metabolism_Homo sapiens_hsa004100.78318347
88Mismatch repair_Homo sapiens_hsa034300.77648330
89Basal cell carcinoma_Homo sapiens_hsa052170.77042180
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.76963252
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76783922
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.76037790
93Caffeine metabolism_Homo sapiens_hsa002320.76011391
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76009116
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75853617
96Hepatitis C_Homo sapiens_hsa051600.75605923
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.74760072
98Dorso-ventral axis formation_Homo sapiens_hsa043200.74475370
99Apoptosis_Homo sapiens_hsa042100.73596441
100Viral carcinogenesis_Homo sapiens_hsa052030.73525720
101Pathways in cancer_Homo sapiens_hsa052000.73139443
102Choline metabolism in cancer_Homo sapiens_hsa052310.71922401
103Spliceosome_Homo sapiens_hsa030400.71503048
104p53 signaling pathway_Homo sapiens_hsa041150.70669671
105Glycerolipid metabolism_Homo sapiens_hsa005610.68468983
106Measles_Homo sapiens_hsa051620.68459934
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.68273789
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66064700
109Insulin signaling pathway_Homo sapiens_hsa049100.65115728
110ABC transporters_Homo sapiens_hsa020100.64662008
111Fructose and mannose metabolism_Homo sapiens_hsa000510.64482579
112Wnt signaling pathway_Homo sapiens_hsa043100.63273184
113Platelet activation_Homo sapiens_hsa046110.62910745
114Phenylalanine metabolism_Homo sapiens_hsa003600.62457061
115Tight junction_Homo sapiens_hsa045300.62187086
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61798328
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61587701
118Basal transcription factors_Homo sapiens_hsa030220.60867741
119T cell receptor signaling pathway_Homo sapiens_hsa046600.60263916
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59528595
121Retinol metabolism_Homo sapiens_hsa008300.58462886
122TNF signaling pathway_Homo sapiens_hsa046680.58332690
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58105961
124Arginine and proline metabolism_Homo sapiens_hsa003300.57832130
125HTLV-I infection_Homo sapiens_hsa051660.57261689
126Bile secretion_Homo sapiens_hsa049760.57239526
127Non-homologous end-joining_Homo sapiens_hsa034500.56510557
128Viral myocarditis_Homo sapiens_hsa054160.56056594
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.55170105
130Glutathione metabolism_Homo sapiens_hsa004800.55095543
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54621330
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.54330330
133Focal adhesion_Homo sapiens_hsa045100.53640810
134Proteoglycans in cancer_Homo sapiens_hsa052050.53580162
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53406623
136Steroid biosynthesis_Homo sapiens_hsa001000.53352976
137FoxO signaling pathway_Homo sapiens_hsa040680.52934901
138Prostate cancer_Homo sapiens_hsa052150.52752589
139Dilated cardiomyopathy_Homo sapiens_hsa054140.51907898
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51314512
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49160396
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46629705
143Tyrosine metabolism_Homo sapiens_hsa003500.45326803
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44635123
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.43576093
146Oocyte meiosis_Homo sapiens_hsa041140.43464001
147ECM-receptor interaction_Homo sapiens_hsa045120.42577829

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