PSMG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.78200579
2DNA strand elongation involved in DNA replication (GO:0006271)4.94748549
3telomere maintenance via semi-conservative replication (GO:0032201)4.89349550
4formation of translation preinitiation complex (GO:0001731)4.74917459
5DNA strand elongation (GO:0022616)4.70633627
6DNA replication initiation (GO:0006270)4.41860019
7transcription from mitochondrial promoter (GO:0006390)4.37585663
8telomere maintenance via recombination (GO:0000722)4.25028091
9nucleobase biosynthetic process (GO:0046112)4.22464237
10ribosome biogenesis (GO:0042254)4.15668698
11maturation of SSU-rRNA (GO:0030490)4.15269520
12ribosomal small subunit assembly (GO:0000028)4.12453999
13regulation of mitochondrial translation (GO:0070129)4.11372342
14DNA unwinding involved in DNA replication (GO:0006268)4.08310652
15purine nucleobase biosynthetic process (GO:0009113)4.01237076
16folic acid-containing compound biosynthetic process (GO:0009396)4.01030040
17mitotic recombination (GO:0006312)3.92066001
18pseudouridine synthesis (GO:0001522)3.88240543
19DNA replication checkpoint (GO:0000076)3.88132381
20telomere maintenance via telomere lengthening (GO:0010833)3.84754551
21ribonucleoprotein complex biogenesis (GO:0022613)3.82309123
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78185055
23ribosome assembly (GO:0042255)3.76265220
24nucleotide-excision repair, DNA gap filling (GO:0006297)3.73810461
25viral transcription (GO:0019083)3.71276035
26DNA replication-dependent nucleosome assembly (GO:0006335)3.66498544
27DNA replication-dependent nucleosome organization (GO:0034723)3.66498544
28IMP biosynthetic process (GO:0006188)3.66446999
29translational termination (GO:0006415)3.66030727
30mitotic chromosome condensation (GO:0007076)3.63303495
31mitotic metaphase plate congression (GO:0007080)3.60817272
32ribosomal large subunit biogenesis (GO:0042273)3.60492180
33nuclear pore complex assembly (GO:0051292)3.59965070
34protein localization to kinetochore (GO:0034501)3.58760981
35spliceosomal snRNP assembly (GO:0000387)3.54297010
36chromatin remodeling at centromere (GO:0031055)3.53616052
37CENP-A containing nucleosome assembly (GO:0034080)3.53115515
38mitotic nuclear envelope disassembly (GO:0007077)3.52941981
39proline biosynthetic process (GO:0006561)3.52126226
40translational initiation (GO:0006413)3.51838288
41chaperone-mediated protein transport (GO:0072321)3.51608215
42rRNA processing (GO:0006364)3.49953447
43translational elongation (GO:0006414)3.47571470
44mitochondrial RNA metabolic process (GO:0000959)3.46855115
45somatic diversification of immune receptors via somatic mutation (GO:0002566)3.46372495
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.46372495
47nuclear pore organization (GO:0006999)3.44217443
48ribosomal small subunit biogenesis (GO:0042274)3.41551509
49viral mRNA export from host cell nucleus (GO:0046784)3.37698092
50nucleobase-containing small molecule interconversion (GO:0015949)3.37656951
51rRNA metabolic process (GO:0016072)3.36973812
52kinetochore assembly (GO:0051382)3.36757900
53protein targeting to mitochondrion (GO:0006626)3.33764818
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.33345802
55sister chromatid segregation (GO:0000819)3.32138717
56maturation of 5.8S rRNA (GO:0000460)3.30362749
57kinetochore organization (GO:0051383)3.30220658
58regulation of translational fidelity (GO:0006450)3.29230899
59oxidative phosphorylation (GO:0006119)3.28430503
60IMP metabolic process (GO:0046040)3.25862548
61rRNA modification (GO:0000154)3.25056615
62transcription-coupled nucleotide-excision repair (GO:0006283)3.24579749
63mitochondrial DNA metabolic process (GO:0032042)3.24479785
64folic acid metabolic process (GO:0046655)3.23696067
65energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23663098
66ATP synthesis coupled proton transport (GO:0015986)3.23663098
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23136383
68nuclear envelope disassembly (GO:0051081)3.22917989
69membrane disassembly (GO:0030397)3.22917989
70* proteasome assembly (GO:0043248)3.21164111
71metaphase plate congression (GO:0051310)3.21081457
72DNA replication-independent nucleosome organization (GO:0034724)3.17958575
73DNA replication-independent nucleosome assembly (GO:0006336)3.17958575
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17545812
75pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.16774491
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.16052036
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15214096
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14168704
79regulation of double-strand break repair via homologous recombination (GO:0010569)3.12808244
80replication fork processing (GO:0031297)3.12397756
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11065437
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09943827
83deoxyribonucleotide biosynthetic process (GO:0009263)3.09871145
84tRNA aminoacylation for protein translation (GO:0006418)3.09349492
85pteridine-containing compound biosynthetic process (GO:0042559)3.08166272
86tRNA aminoacylation (GO:0043039)3.07113182
87amino acid activation (GO:0043038)3.07113182
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06966401
89protein localization to chromosome, centromeric region (GO:0071459)3.03181366
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02745277
91establishment of integrated proviral latency (GO:0075713)3.01171672
92base-excision repair (GO:0006284)3.00523518
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.00190115
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99890765
95protein localization to mitochondrion (GO:0070585)2.99428794
96cotranslational protein targeting to membrane (GO:0006613)2.99290251
97regulation of translational termination (GO:0006449)2.98901901
98mitochondrial DNA replication (GO:0006264)2.98878759
99protein targeting to ER (GO:0045047)2.98817582
100establishment of protein localization to mitochondrion (GO:0072655)2.98442089
101cell cycle G1/S phase transition (GO:0044843)2.97490624
102G1/S transition of mitotic cell cycle (GO:0000082)2.97490624
103mitotic sister chromatid segregation (GO:0000070)2.97457273
104chromatin assembly or disassembly (GO:0006333)2.96365738
105termination of RNA polymerase III transcription (GO:0006386)2.94767071
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.94767071
107cellular component biogenesis (GO:0044085)2.94521773
108establishment of viral latency (GO:0019043)2.93619744
109translation (GO:0006412)2.92595360
110cullin deneddylation (GO:0010388)2.92017501
111DNA duplex unwinding (GO:0032508)2.91334401
112DNA catabolic process, exonucleolytic (GO:0000738)2.90951746
113negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90736067
114DNA geometric change (GO:0032392)2.90258887
115meiotic chromosome segregation (GO:0045132)2.89841404
116negative regulation of ligase activity (GO:0051352)2.89685956
117negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89685956
118histone exchange (GO:0043486)2.87680704
119viral life cycle (GO:0019058)2.86825037
120protein deneddylation (GO:0000338)2.86666244
121telomere organization (GO:0032200)2.86241031
122telomere maintenance (GO:0000723)2.85244532
123protein localization to endoplasmic reticulum (GO:0070972)2.83502468
124mitotic G1 DNA damage checkpoint (GO:0031571)2.82304727
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82159361
126cellular protein complex disassembly (GO:0043624)2.81627088
127negative regulation of chromosome segregation (GO:0051985)2.81488809
128termination of RNA polymerase II transcription (GO:0006369)2.80767413
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.80681770
130establishment of protein localization to endoplasmic reticulum (GO:0072599)2.80315137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14078038
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.49707069
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92861830
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07258188
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05251744
6MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04898574
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.99241364
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93695822
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93546003
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89257610
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.82228000
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.78036477
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75236597
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.72106866
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44354093
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38310098
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36337160
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27548479
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26243774
20XRN2_22483619_ChIP-Seq_HELA_Human2.25869653
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18632182
22* VDR_23849224_ChIP-Seq_CD4+_Human2.04487483
23DCP1A_22483619_ChIP-Seq_HELA_Human2.01056390
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93436827
25GABP_19822575_ChIP-Seq_HepG2_Human1.88978848
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85988514
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85199379
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83791333
29FOXP3_21729870_ChIP-Seq_TREG_Human1.83628898
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82012837
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80234091
32TTF2_22483619_ChIP-Seq_HELA_Human1.75597046
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74460296
34AR_21909140_ChIP-Seq_LNCAP_Human1.74232028
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.70215147
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68915904
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68531749
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68393171
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67343384
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.65271855
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64098220
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61019426
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60530630
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59905412
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58283276
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53624270
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.53262581
48MYC_22102868_ChIP-Seq_BL_Human1.53044616
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45248140
50ZNF263_19887448_ChIP-Seq_K562_Human1.42549526
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40495835
52KDM5A_27292631_Chip-Seq_BREAST_Human1.38103718
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34798558
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34242485
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33017623
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31101865
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31101865
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31101865
59ELK1_19687146_ChIP-ChIP_HELA_Human1.30249324
60CIITA_25753668_ChIP-Seq_RAJI_Human1.28026746
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27286195
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26895862
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24994064
64* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24954591
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24161697
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23752661
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23077507
68MYC_18940864_ChIP-ChIP_HL60_Human1.21738538
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20804475
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20607855
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17443075
72* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16199117
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14634802
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14001060
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13680890
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12630213
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.12130502
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11162244
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.09961348
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09552283
81VDR_21846776_ChIP-Seq_THP-1_Human1.08574879
82TFEB_21752829_ChIP-Seq_HELA_Human1.06869380
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06157727
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05482287
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02049664
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01354269
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00381656
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99915825
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99340834
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99114818
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98473182
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98471356
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98127820
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97941494
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97883078
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97604827
97OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97354048
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96402551
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95980162
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.94748458
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94710947
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94276240
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93995326
104TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91920153
105TP63_19390658_ChIP-ChIP_HaCaT_Human0.91841516
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91629931
107* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90063148
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87719579
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87338017
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.86931966
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86094128
112TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86089237
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84630866
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84566074
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84420690
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82375482
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81521265
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77272036
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71015924
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.70497537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.05184008
2MP0004957_abnormal_blastocyst_morpholog4.39577273
3MP0008057_abnormal_DNA_replication4.37889131
4MP0010094_abnormal_chromosome_stability4.32403943
5MP0003111_abnormal_nucleus_morphology4.04917213
6MP0003077_abnormal_cell_cycle3.64822790
7MP0008058_abnormal_DNA_repair3.26604200
8MP0003806_abnormal_nucleotide_metabolis3.20648693
9MP0009697_abnormal_copulation2.63613075
10MP0008932_abnormal_embryonic_tissue2.59539712
11MP0008007_abnormal_cellular_replicative2.53320332
12MP0002396_abnormal_hematopoietic_system2.26051173
13MP0003786_premature_aging2.24475528
14MP0001730_embryonic_growth_arrest2.18382394
15MP0010352_gastrointestinal_tract_polyps2.02937630
16MP0002877_abnormal_melanocyte_morpholog2.02936646
17MP0003718_maternal_effect1.98703502
18MP0000350_abnormal_cell_proliferation1.98012401
19MP0003123_paternal_imprinting1.83938364
20MP0000490_abnormal_crypts_of1.83665468
21MP0004147_increased_porphyrin_level1.81596087
22MP0010030_abnormal_orbit_morphology1.78142514
23MP0003941_abnormal_skin_development1.78117727
24MP0008877_abnormal_DNA_methylation1.77999644
25MP0000372_irregular_coat_pigmentation1.73964186
26MP0001697_abnormal_embryo_size1.66997722
27MP0003186_abnormal_redox_activity1.62426979
28MP0004133_heterotaxia1.60869382
29* MP0005380_embryogenesis_phenotype1.59917622
30* MP0001672_abnormal_embryogenesis/_devel1.59917622
31* MP0002080_prenatal_lethality1.53159466
32MP0002653_abnormal_ependyma_morphology1.49838832
33MP0002085_abnormal_embryonic_tissue1.44673448
34MP0009379_abnormal_foot_pigmentation1.44393737
35MP0000313_abnormal_cell_death1.44302594
36MP0002019_abnormal_tumor_incidence1.43707276
37MP0003890_abnormal_embryonic-extraembry1.43026892
38MP0001545_abnormal_hematopoietic_system1.42391265
39MP0005397_hematopoietic_system_phenotyp1.42391265
40MP0003984_embryonic_growth_retardation1.40727068
41MP0001293_anophthalmia1.40348059
42MP0010307_abnormal_tumor_latency1.39552987
43MP0002088_abnormal_embryonic_growth/wei1.37882944
44MP0002084_abnormal_developmental_patter1.36352367
45MP0002086_abnormal_extraembryonic_tissu1.35276124
46MP0006036_abnormal_mitochondrial_physio1.34591994
47MP0006292_abnormal_olfactory_placode1.32706948
48MP0003567_abnormal_fetal_cardiomyocyte1.30290983
49MP0005075_abnormal_melanosome_morpholog1.29637868
50MP0004197_abnormal_fetal_growth/weight/1.28069238
51MP0003315_abnormal_perineum_morphology1.20136343
52MP0002210_abnormal_sex_determination1.18245494
53MP0009333_abnormal_splenocyte_physiolog1.17826233
54MP0005266_abnormal_metabolism1.17773182
55MP0005501_abnormal_skin_physiology1.17575672
56MP0001661_extended_life_span1.14204751
57MP0003119_abnormal_digestive_system1.13136811
58MP0006035_abnormal_mitochondrial_morpho1.12927054
59MP0000358_abnormal_cell_content/1.11813003
60MP0001145_abnormal_male_reproductive1.10793639
61MP0005408_hypopigmentation1.08916565
62MP0002938_white_spotting1.01585195
63MP0002132_abnormal_respiratory_system0.99594374
64MP0005451_abnormal_body_composition0.97129506
65MP0004808_abnormal_hematopoietic_stem0.97082556
66MP0003763_abnormal_thymus_physiology0.96504073
67MP0001881_abnormal_mammary_gland0.95946532
68MP0008995_early_reproductive_senescence0.95881436
69MP0000689_abnormal_spleen_morphology0.93117713
70MP0001764_abnormal_homeostasis0.92940213
71MP0001188_hyperpigmentation0.92562904
72MP0000653_abnormal_sex_gland0.91298994
73MP0001929_abnormal_gametogenesis0.90913598
74MP0002722_abnormal_immune_system0.90044806
75MP0000703_abnormal_thymus_morphology0.86253116
76MP0003221_abnormal_cardiomyocyte_apopto0.85826692
77MP0002111_abnormal_tail_morphology0.85376962
78MP0002163_abnormal_gland_morphology0.85008052
79MP0002269_muscular_atrophy0.82556252
80MP0009278_abnormal_bone_marrow0.82114629
81MP0003937_abnormal_limbs/digits/tail_de0.81601724
82MP0001119_abnormal_female_reproductive0.79702756
83MP0001853_heart_inflammation0.79646902
84MP0000678_abnormal_parathyroid_gland0.78872183
85MP0002398_abnormal_bone_marrow0.78229714
86MP0002160_abnormal_reproductive_system0.77210304
87MP0001529_abnormal_vocalization0.76968701
88MP0003656_abnormal_erythrocyte_physiolo0.75754520
89MP0005187_abnormal_penis_morphology0.74208117
90MP0008789_abnormal_olfactory_epithelium0.74179429
91MP0002796_impaired_skin_barrier0.73400685
92MP0002161_abnormal_fertility/fecundity0.71997315
93MP0005389_reproductive_system_phenotype0.71368227
94MP0009672_abnormal_birth_weight0.71358213
95* MP0000598_abnormal_liver_morphology0.70771438
96MP0000858_altered_metastatic_potential0.70503082
97MP0005023_abnormal_wound_healing0.70166215
98MP0000750_abnormal_muscle_regeneration0.68069422
99MP0002429_abnormal_blood_cell0.67275537
100MP0003698_abnormal_male_reproductive0.67272735
101MP0009840_abnormal_foam_cell0.65753788
102MP0000477_abnormal_intestine_morphology0.65740224
103MP0005384_cellular_phenotype0.65728611
104MP0002095_abnormal_skin_pigmentation0.64727313
105MP0001727_abnormal_embryo_implantation0.63996369
106MP0003646_muscle_fatigue0.63883071
107MP0004264_abnormal_extraembryonic_tissu0.63759468
108MP0005330_cardiomyopathy0.63534677
109MP0004185_abnormal_adipocyte_glucose0.63177126
110MP0005319_abnormal_enzyme/_coenzyme0.63133548
111MP0003136_yellow_coat_color0.62608280
112MP0005365_abnormal_bile_salt0.62344723
113MP0005085_abnormal_gallbladder_physiolo0.62002854
114MP0009053_abnormal_anal_canal0.61791469
115MP0002234_abnormal_pharynx_morphology0.61760651
116MP0005395_other_phenotype0.61305868
117MP0004233_abnormal_muscle_weight0.60926838
118MP0002332_abnormal_exercise_endurance0.59570438
119MP0005376_homeostasis/metabolism_phenot0.59066741
120MP0001919_abnormal_reproductive_system0.58081008
121MP0005076_abnormal_cell_differentiation0.56960432
122MP0003699_abnormal_female_reproductive0.55594344
123MP0002970_abnormal_white_adipose0.54949078
124MP0000627_abnormal_mammary_gland0.54722592
125MP0005332_abnormal_amino_acid0.54609775
126MP0005636_abnormal_mineral_homeostasis0.54189233
127MP0000049_abnormal_middle_ear0.54117455
128MP0003283_abnormal_digestive_organ0.54072333
129MP0005621_abnormal_cell_physiology0.52956578
130MP0002075_abnormal_coat/hair_pigmentati0.52936691
131MP0005410_abnormal_fertilization0.52212272
132MP0000371_diluted_coat_color0.52198262
133MP0002697_abnormal_eye_size0.51388680
134MP0003385_abnormal_body_wall0.51160510
135MP0009703_decreased_birth_body0.50807488
136MP0000647_abnormal_sebaceous_gland0.49795011

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.42454042
2Abnormal number of erythroid precursors (HP:0012131)4.33198806
3Oral leukoplakia (HP:0002745)4.21280017
4Birth length less than 3rd percentile (HP:0003561)4.05550894
5Reticulocytopenia (HP:0001896)4.01738142
6Acute necrotizing encephalopathy (HP:0006965)3.72075075
7Abnormal mitochondria in muscle tissue (HP:0008316)3.71006396
8Acute encephalopathy (HP:0006846)3.69111226
9Selective tooth agenesis (HP:0001592)3.60062647
10Breast hypoplasia (HP:0003187)3.53022596
11Aplastic anemia (HP:0001915)3.37789783
12Increased CSF lactate (HP:0002490)3.34882785
13Carpal bone hypoplasia (HP:0001498)3.23622725
14Rough bone trabeculation (HP:0100670)3.20567932
15Mitochondrial inheritance (HP:0001427)3.15338662
16Colon cancer (HP:0003003)3.14266155
17Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.10333227
18Increased hepatocellular lipid droplets (HP:0006565)3.09847753
19Absent thumb (HP:0009777)3.08189895
20Cerebral hypomyelination (HP:0006808)3.07147914
21Degeneration of anterior horn cells (HP:0002398)3.05647401
22Abnormality of the anterior horn cell (HP:0006802)3.05647401
23Hepatocellular necrosis (HP:0001404)2.99713142
24Hepatic necrosis (HP:0002605)2.97284783
25Patellar aplasia (HP:0006443)2.96052957
26Lipid accumulation in hepatocytes (HP:0006561)2.89314289
27Ependymoma (HP:0002888)2.88180586
28Progressive macrocephaly (HP:0004481)2.88175936
29Cerebral edema (HP:0002181)2.88154068
30Premature graying of hair (HP:0002216)2.85607438
31Macrocytic anemia (HP:0001972)2.83839794
32Chromsome breakage (HP:0040012)2.83495540
33Absent radius (HP:0003974)2.80970458
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80656416
35Abnormality of the ileum (HP:0001549)2.78963978
36Aplasia/Hypoplasia of the patella (HP:0006498)2.77457831
37Microretrognathia (HP:0000308)2.70401202
38Multiple enchondromatosis (HP:0005701)2.69745121
39Medulloblastoma (HP:0002885)2.68426459
40Pallor (HP:0000980)2.65328922
41Lactic acidosis (HP:0003128)2.65311603
42Meckel diverticulum (HP:0002245)2.60572465
43Aplasia involving forearm bones (HP:0009822)2.59212676
44Absent forearm bone (HP:0003953)2.59212676
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.56919763
46Abnormal protein N-linked glycosylation (HP:0012347)2.56919763
47Abnormal protein glycosylation (HP:0012346)2.56919763
48Abnormal glycosylation (HP:0012345)2.56919763
49Abnormality of the preputium (HP:0100587)2.56600104
50Short middle phalanx of the 5th finger (HP:0004220)2.56233938
51Increased intramyocellular lipid droplets (HP:0012240)2.54941837
52Squamous cell carcinoma (HP:0002860)2.54217076
53Rhabdomyosarcoma (HP:0002859)2.54034887
54Progressive muscle weakness (HP:0003323)2.53527788
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52406285
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52406285
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51256447
58Trismus (HP:0000211)2.51037922
59Premature ovarian failure (HP:0008209)2.48835024
60Abnormality of pyrimidine metabolism (HP:0004353)2.47096290
61Supernumerary spleens (HP:0009799)2.46314909
62Rectal fistula (HP:0100590)2.42867863
63Rectovaginal fistula (HP:0000143)2.42867863
64Impulsivity (HP:0100710)2.41914480
65Abnormality of the fetal cardiovascular system (HP:0010948)2.38783097
66Abnormal umbilical cord blood vessels (HP:0011403)2.38783097
67Single umbilical artery (HP:0001195)2.38783097
68Myelodysplasia (HP:0002863)2.37959025
69Abnormality of chromosome stability (HP:0003220)2.37544158
70Abnormality of alanine metabolism (HP:0010916)2.37228883
71Hyperalaninemia (HP:0003348)2.37228883
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37228883
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.34446821
74Renal Fanconi syndrome (HP:0001994)2.33845186
75Aplasia/hypoplasia of the humerus (HP:0006507)2.33646940
76Abnormality of methionine metabolism (HP:0010901)2.33076255
77Rib fusion (HP:0000902)2.31954963
78Basal cell carcinoma (HP:0002671)2.30646952
79Pancytopenia (HP:0001876)2.29282948
80Cellular immunodeficiency (HP:0005374)2.29123847
81Neoplasm of the pancreas (HP:0002894)2.28730256
82Type I transferrin isoform profile (HP:0003642)2.27040192
83Exercise intolerance (HP:0003546)2.26067534
84Secondary amenorrhea (HP:0000869)2.25949487
85Increased serum lactate (HP:0002151)2.24667047
86Respiratory difficulties (HP:0002880)2.24639512
87Abnormal number of incisors (HP:0011064)2.23171610
88Bone marrow hypocellularity (HP:0005528)2.22042041
89Poikiloderma (HP:0001029)2.21583483
90Muscle fiber atrophy (HP:0100295)2.19231421
91Vaginal fistula (HP:0004320)2.17135124
92Abnormal trabecular bone morphology (HP:0100671)2.16184792
93Agnosia (HP:0010524)2.15448025
94Tongue fasciculations (HP:0001308)2.15035732
95Megaloblastic anemia (HP:0001889)2.12416297
96Increased muscle lipid content (HP:0009058)2.11998116
97Testicular atrophy (HP:0000029)2.10117401
98Microvesicular hepatic steatosis (HP:0001414)2.09948993
99Abnormality of the umbilical cord (HP:0010881)2.09187876
100Respiratory failure (HP:0002878)2.07636169
101Sparse eyelashes (HP:0000653)2.06664608
102Abdominal situs inversus (HP:0003363)2.05355251
103Abnormality of abdominal situs (HP:0011620)2.05355251
104Ragged-red muscle fibers (HP:0003200)2.03087456
105Type 2 muscle fiber atrophy (HP:0003554)2.02310166
106Small intestinal stenosis (HP:0012848)2.00729243
107Duodenal stenosis (HP:0100867)2.00729243
108Abnormality of serum amino acid levels (HP:0003112)2.00721415
109Abnormal gallbladder physiology (HP:0012438)2.00718553
110Cholecystitis (HP:0001082)2.00718553
111Intestinal fistula (HP:0100819)2.00334831
112Facial hemangioma (HP:0000329)1.97051396
113Horseshoe kidney (HP:0000085)1.96839439
114Abnormality of the labia minora (HP:0012880)1.92785016
115Abnormal lung lobation (HP:0002101)1.92747241
116Hypoplasia of the radius (HP:0002984)1.92109542
117Muscle fibrillation (HP:0010546)1.91348943
118Tracheoesophageal fistula (HP:0002575)1.88298704
119Sloping forehead (HP:0000340)1.87903653
12011 pairs of ribs (HP:0000878)1.87221865
121Hyperglycinemia (HP:0002154)1.87070125
122Asplenia (HP:0001746)1.86722323
123Gout (HP:0001997)1.85245417
124Abnormality of the carotid arteries (HP:0005344)1.85087323
125Atrophy/Degeneration involving motor neurons (HP:0007373)1.84734537
126Increased nuchal translucency (HP:0010880)1.84490596
127Lethargy (HP:0001254)1.84227457
128Short humerus (HP:0005792)1.83880076
129Cleft eyelid (HP:0000625)1.83663713
130Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83314779
131Leukodystrophy (HP:0002415)1.82999189
132Triphalangeal thumb (HP:0001199)1.77686692
133Abnormal hemoglobin (HP:0011902)1.77650987
134Neoplasm of striated muscle (HP:0009728)1.77313865
135Lymphoma (HP:0002665)1.75946109
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75890366
137Increased serum pyruvate (HP:0003542)1.75679108
138Abnormality of glycolysis (HP:0004366)1.75679108
139Facial cleft (HP:0002006)1.75574014
140Nausea (HP:0002018)1.75464800
141Abnormality of reticulocytes (HP:0004312)1.75447165
142Abnormality of the duodenum (HP:0002246)1.74837479
143Hypoglycemic coma (HP:0001325)1.74415833
144Reduced antithrombin III activity (HP:0001976)1.74368856
1453-Methylglutaconic aciduria (HP:0003535)1.73870533
146Abnormalities of placenta or umbilical cord (HP:0001194)1.73406333
147Proximal placement of thumb (HP:0009623)1.72068718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.52685620
2WEE14.29758569
3EIF2AK13.58140158
4CDC73.48271273
5VRK23.16772238
6NME22.46116841
7STK162.26686794
8EIF2AK32.21988944
9NEK12.15327306
10CDK72.13473686
11NEK22.13305533
12TTK2.10876685
13SRPK12.06228353
14PLK42.05974432
15PLK12.05763584
16BRSK22.00767210
17TSSK62.00187422
18PDK21.96922625
19TESK21.96327000
20BCKDK1.86031433
21DYRK31.84860620
22ACVR1B1.84777615
23RPS6KB21.75413562
24MAP3K111.67434449
25TRIM281.66258564
26MST41.60074171
27VRK11.56644019
28EPHA21.55965083
29ATR1.53511138
30PIM21.52101083
31AURKB1.51897800
32SCYL21.43464988
33CHEK21.42775601
34PASK1.39562774
35KDR1.38587794
36MKNK11.37145051
37AURKA1.36743276
38TLK11.33148151
39FLT31.22510429
40NUAK11.20373440
41CDK41.18739692
42MAP3K81.18328884
43CDK121.17586591
44BRSK11.16539428
45PAK41.16335079
46TAF11.10844456
47RPS6KA41.08919690
48PLK31.08360216
49SMG11.07553361
50MAP3K61.06649356
51PIM10.99658281
52CHEK10.98443687
53STK100.97996747
54ICK0.94543902
55ARAF0.93259007
56MKNK20.92641380
57EIF2AK20.88891396
58STK40.87819118
59MAPKAPK30.87371019
60TGFBR10.87001322
61MATK0.86416365
62MAP2K30.85989151
63CLK10.84296818
64EEF2K0.83442758
65CSNK2A10.81492047
66CSNK1G30.80538741
67CDK60.80389432
68DAPK10.78817333
69ZAK0.77235803
70CSNK2A20.76614344
71CDK20.75601770
72CDK80.72601405
73TAOK20.71038975
74MAP3K100.70937307
75ATM0.70316569
76YES10.67824146
77RAF10.64957152
78ILK0.63711559
79CSNK1G10.63607102
80PINK10.63327230
81STK30.60902312
82PAK10.60644270
83MAP4K10.58346522
84CCNB10.57373837
85ALK0.56380412
86DDR20.56282491
87BMPR1B0.56250634
88IRAK30.55900586
89MAPK110.55484745
90DYRK20.55411429
91CSNK1A1L0.54810766
92LATS20.50916305
93MAPK150.49948701
94BLK0.49894005
95TESK10.48756306
96PRKCI0.48195300
97LRRK20.47690599
98CDK10.47651957
99CSNK1E0.46016708
100MST1R0.44622951
101BRAF0.43243141
102CSNK1G20.42028928
103AKT20.41685142
104MAPKAPK50.40866800
105ERBB40.40556432
106MTOR0.40169471
107DYRK1B0.40031639
108PBK0.39522088
109CDK90.38652882
110MAP2K60.35370392
111ABL20.35304920
112CDK30.34322650
113NME10.32468389
114BTK0.32348628
115GRK60.32000800
116ZAP700.31891784
117CDK11A0.31579432
118CDK140.31422508
119PDK30.31241522
120PDK40.31241522
121RPS6KA50.30553106
122PRKDC0.30317841
123CDK180.30290478
124PLK20.29870229
125MAP3K120.29735666
126RPS6KL10.28313361
127RPS6KC10.28313361
128MAP4K20.28310169
129STK38L0.28113699
130WNK40.27476900
131CDK150.27431696
132STK240.27005484
133RPS6KA60.25000617
134BCR0.24986995

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02809330
2Mismatch repair_Homo sapiens_hsa034304.44414073
3Ribosome_Homo sapiens_hsa030103.53874323
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53630562
5Proteasome_Homo sapiens_hsa030503.39794303
6Base excision repair_Homo sapiens_hsa034103.17500043
7Spliceosome_Homo sapiens_hsa030403.03935226
8RNA polymerase_Homo sapiens_hsa030202.95467170
9One carbon pool by folate_Homo sapiens_hsa006702.84311500
10RNA transport_Homo sapiens_hsa030132.83905747
11Homologous recombination_Homo sapiens_hsa034402.82625045
12Nucleotide excision repair_Homo sapiens_hsa034202.81756673
13Pyrimidine metabolism_Homo sapiens_hsa002402.43030841
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28669953
15Cell cycle_Homo sapiens_hsa041102.17287419
16Fanconi anemia pathway_Homo sapiens_hsa034602.00599685
17RNA degradation_Homo sapiens_hsa030181.67707074
18Non-homologous end-joining_Homo sapiens_hsa034501.58400353
19Folate biosynthesis_Homo sapiens_hsa007901.56079890
20Basal transcription factors_Homo sapiens_hsa030221.53131565
21Biosynthesis of amino acids_Homo sapiens_hsa012301.43817974
22Fatty acid elongation_Homo sapiens_hsa000621.41115548
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.39572417
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35736197
25p53 signaling pathway_Homo sapiens_hsa041151.32866027
26mRNA surveillance pathway_Homo sapiens_hsa030151.31711064
27Selenocompound metabolism_Homo sapiens_hsa004501.22505286
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21452157
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20274677
30Sulfur relay system_Homo sapiens_hsa041221.20098806
31Purine metabolism_Homo sapiens_hsa002301.19146229
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.16452318
33Alzheimers disease_Homo sapiens_hsa050101.16091922
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10646773
35Pentose phosphate pathway_Homo sapiens_hsa000301.04754568
36Carbon metabolism_Homo sapiens_hsa012000.96261182
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.91370315
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90440598
39Epstein-Barr virus infection_Homo sapiens_hsa051690.89902746
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89430061
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86222718
42Vitamin B6 metabolism_Homo sapiens_hsa007500.85023513
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84801739
44Glutathione metabolism_Homo sapiens_hsa004800.84205544
45Fructose and mannose metabolism_Homo sapiens_hsa000510.78281766
46Systemic lupus erythematosus_Homo sapiens_hsa053220.76890172
47Steroid biosynthesis_Homo sapiens_hsa001000.74939109
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71816606
49Arginine and proline metabolism_Homo sapiens_hsa003300.68828120
50Galactose metabolism_Homo sapiens_hsa000520.66439751
51Huntingtons disease_Homo sapiens_hsa050160.64652200
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63746085
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62952044
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62083584
55Herpes simplex infection_Homo sapiens_hsa051680.61877889
56Sulfur metabolism_Homo sapiens_hsa009200.61013184
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59354415
58Oocyte meiosis_Homo sapiens_hsa041140.58556125
59Viral carcinogenesis_Homo sapiens_hsa052030.58112961
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57948622
61Parkinsons disease_Homo sapiens_hsa050120.56926349
62Protein export_Homo sapiens_hsa030600.55204139
63Fatty acid metabolism_Homo sapiens_hsa012120.52321519
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52083938
65Antigen processing and presentation_Homo sapiens_hsa046120.51829812
66Thyroid cancer_Homo sapiens_hsa052160.51544574
67Legionellosis_Homo sapiens_hsa051340.51389984
68Metabolic pathways_Homo sapiens_hsa011000.46464570
69Pyruvate metabolism_Homo sapiens_hsa006200.44647638
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42782772
71Cardiac muscle contraction_Homo sapiens_hsa042600.42246771
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41623424
73N-Glycan biosynthesis_Homo sapiens_hsa005100.38313906
74HTLV-I infection_Homo sapiens_hsa051660.38148818
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36300949
76Oxidative phosphorylation_Homo sapiens_hsa001900.36010300
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35393690
78Primary immunodeficiency_Homo sapiens_hsa053400.32568883
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30894967
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30268342
81Bladder cancer_Homo sapiens_hsa052190.29364240
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29015483
83Propanoate metabolism_Homo sapiens_hsa006400.27884979
84Peroxisome_Homo sapiens_hsa041460.26754690
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26652731
86Tyrosine metabolism_Homo sapiens_hsa003500.24954845
87Arachidonic acid metabolism_Homo sapiens_hsa005900.24642584
88Fatty acid biosynthesis_Homo sapiens_hsa000610.21956305
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21547261
90Shigellosis_Homo sapiens_hsa051310.21296981
91Butanoate metabolism_Homo sapiens_hsa006500.21158067
92Small cell lung cancer_Homo sapiens_hsa052220.20835725
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20633732
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20617668
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.20421477
96TGF-beta signaling pathway_Homo sapiens_hsa043500.20170973
97Notch signaling pathway_Homo sapiens_hsa043300.19525362
98Hippo signaling pathway_Homo sapiens_hsa043900.19260518
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18440933
100Vitamin digestion and absorption_Homo sapiens_hsa049770.16768488
101MicroRNAs in cancer_Homo sapiens_hsa052060.16706609
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16522221
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15764750
104Fatty acid degradation_Homo sapiens_hsa000710.14762117
105Apoptosis_Homo sapiens_hsa042100.14402848
106Basal cell carcinoma_Homo sapiens_hsa052170.14233514
107beta-Alanine metabolism_Homo sapiens_hsa004100.14143846
108Fat digestion and absorption_Homo sapiens_hsa049750.14082815
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14045730
110Arginine biosynthesis_Homo sapiens_hsa002200.14017025
111Linoleic acid metabolism_Homo sapiens_hsa005910.13501249
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.13211370
113Lysine degradation_Homo sapiens_hsa003100.13165257
114Alcoholism_Homo sapiens_hsa050340.12474249
115Phenylalanine metabolism_Homo sapiens_hsa003600.10009010
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.02139865
117Vibrio cholerae infection_Homo sapiens_hsa05110-0.0085476

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