

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.78200579 |
| 2 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.94748549 |
| 3 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.89349550 |
| 4 | formation of translation preinitiation complex (GO:0001731) | 4.74917459 |
| 5 | DNA strand elongation (GO:0022616) | 4.70633627 |
| 6 | DNA replication initiation (GO:0006270) | 4.41860019 |
| 7 | transcription from mitochondrial promoter (GO:0006390) | 4.37585663 |
| 8 | telomere maintenance via recombination (GO:0000722) | 4.25028091 |
| 9 | nucleobase biosynthetic process (GO:0046112) | 4.22464237 |
| 10 | ribosome biogenesis (GO:0042254) | 4.15668698 |
| 11 | maturation of SSU-rRNA (GO:0030490) | 4.15269520 |
| 12 | ribosomal small subunit assembly (GO:0000028) | 4.12453999 |
| 13 | regulation of mitochondrial translation (GO:0070129) | 4.11372342 |
| 14 | DNA unwinding involved in DNA replication (GO:0006268) | 4.08310652 |
| 15 | purine nucleobase biosynthetic process (GO:0009113) | 4.01237076 |
| 16 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.01030040 |
| 17 | mitotic recombination (GO:0006312) | 3.92066001 |
| 18 | pseudouridine synthesis (GO:0001522) | 3.88240543 |
| 19 | DNA replication checkpoint (GO:0000076) | 3.88132381 |
| 20 | telomere maintenance via telomere lengthening (GO:0010833) | 3.84754551 |
| 21 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.82309123 |
| 22 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.78185055 |
| 23 | ribosome assembly (GO:0042255) | 3.76265220 |
| 24 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.73810461 |
| 25 | viral transcription (GO:0019083) | 3.71276035 |
| 26 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.66498544 |
| 27 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.66498544 |
| 28 | IMP biosynthetic process (GO:0006188) | 3.66446999 |
| 29 | translational termination (GO:0006415) | 3.66030727 |
| 30 | mitotic chromosome condensation (GO:0007076) | 3.63303495 |
| 31 | mitotic metaphase plate congression (GO:0007080) | 3.60817272 |
| 32 | ribosomal large subunit biogenesis (GO:0042273) | 3.60492180 |
| 33 | nuclear pore complex assembly (GO:0051292) | 3.59965070 |
| 34 | protein localization to kinetochore (GO:0034501) | 3.58760981 |
| 35 | spliceosomal snRNP assembly (GO:0000387) | 3.54297010 |
| 36 | chromatin remodeling at centromere (GO:0031055) | 3.53616052 |
| 37 | CENP-A containing nucleosome assembly (GO:0034080) | 3.53115515 |
| 38 | mitotic nuclear envelope disassembly (GO:0007077) | 3.52941981 |
| 39 | proline biosynthetic process (GO:0006561) | 3.52126226 |
| 40 | translational initiation (GO:0006413) | 3.51838288 |
| 41 | chaperone-mediated protein transport (GO:0072321) | 3.51608215 |
| 42 | rRNA processing (GO:0006364) | 3.49953447 |
| 43 | translational elongation (GO:0006414) | 3.47571470 |
| 44 | mitochondrial RNA metabolic process (GO:0000959) | 3.46855115 |
| 45 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.46372495 |
| 46 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.46372495 |
| 47 | nuclear pore organization (GO:0006999) | 3.44217443 |
| 48 | ribosomal small subunit biogenesis (GO:0042274) | 3.41551509 |
| 49 | viral mRNA export from host cell nucleus (GO:0046784) | 3.37698092 |
| 50 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.37656951 |
| 51 | rRNA metabolic process (GO:0016072) | 3.36973812 |
| 52 | kinetochore assembly (GO:0051382) | 3.36757900 |
| 53 | protein targeting to mitochondrion (GO:0006626) | 3.33764818 |
| 54 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.33345802 |
| 55 | sister chromatid segregation (GO:0000819) | 3.32138717 |
| 56 | maturation of 5.8S rRNA (GO:0000460) | 3.30362749 |
| 57 | kinetochore organization (GO:0051383) | 3.30220658 |
| 58 | regulation of translational fidelity (GO:0006450) | 3.29230899 |
| 59 | oxidative phosphorylation (GO:0006119) | 3.28430503 |
| 60 | IMP metabolic process (GO:0046040) | 3.25862548 |
| 61 | rRNA modification (GO:0000154) | 3.25056615 |
| 62 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.24579749 |
| 63 | mitochondrial DNA metabolic process (GO:0032042) | 3.24479785 |
| 64 | folic acid metabolic process (GO:0046655) | 3.23696067 |
| 65 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.23663098 |
| 66 | ATP synthesis coupled proton transport (GO:0015986) | 3.23663098 |
| 67 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.23136383 |
| 68 | nuclear envelope disassembly (GO:0051081) | 3.22917989 |
| 69 | membrane disassembly (GO:0030397) | 3.22917989 |
| 70 | * proteasome assembly (GO:0043248) | 3.21164111 |
| 71 | metaphase plate congression (GO:0051310) | 3.21081457 |
| 72 | DNA replication-independent nucleosome organization (GO:0034724) | 3.17958575 |
| 73 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.17958575 |
| 74 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.17545812 |
| 75 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.16774491 |
| 76 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.16052036 |
| 77 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.15214096 |
| 78 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.14168704 |
| 79 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.12808244 |
| 80 | replication fork processing (GO:0031297) | 3.12397756 |
| 81 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.11065437 |
| 82 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.09943827 |
| 83 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.09871145 |
| 84 | tRNA aminoacylation for protein translation (GO:0006418) | 3.09349492 |
| 85 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.08166272 |
| 86 | tRNA aminoacylation (GO:0043039) | 3.07113182 |
| 87 | amino acid activation (GO:0043038) | 3.07113182 |
| 88 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.06966401 |
| 89 | protein localization to chromosome, centromeric region (GO:0071459) | 3.03181366 |
| 90 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.02745277 |
| 91 | establishment of integrated proviral latency (GO:0075713) | 3.01171672 |
| 92 | base-excision repair (GO:0006284) | 3.00523518 |
| 93 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.00190115 |
| 94 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.99890765 |
| 95 | protein localization to mitochondrion (GO:0070585) | 2.99428794 |
| 96 | cotranslational protein targeting to membrane (GO:0006613) | 2.99290251 |
| 97 | regulation of translational termination (GO:0006449) | 2.98901901 |
| 98 | mitochondrial DNA replication (GO:0006264) | 2.98878759 |
| 99 | protein targeting to ER (GO:0045047) | 2.98817582 |
| 100 | establishment of protein localization to mitochondrion (GO:0072655) | 2.98442089 |
| 101 | cell cycle G1/S phase transition (GO:0044843) | 2.97490624 |
| 102 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.97490624 |
| 103 | mitotic sister chromatid segregation (GO:0000070) | 2.97457273 |
| 104 | chromatin assembly or disassembly (GO:0006333) | 2.96365738 |
| 105 | termination of RNA polymerase III transcription (GO:0006386) | 2.94767071 |
| 106 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.94767071 |
| 107 | cellular component biogenesis (GO:0044085) | 2.94521773 |
| 108 | establishment of viral latency (GO:0019043) | 2.93619744 |
| 109 | translation (GO:0006412) | 2.92595360 |
| 110 | cullin deneddylation (GO:0010388) | 2.92017501 |
| 111 | DNA duplex unwinding (GO:0032508) | 2.91334401 |
| 112 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.90951746 |
| 113 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.90736067 |
| 114 | DNA geometric change (GO:0032392) | 2.90258887 |
| 115 | meiotic chromosome segregation (GO:0045132) | 2.89841404 |
| 116 | negative regulation of ligase activity (GO:0051352) | 2.89685956 |
| 117 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.89685956 |
| 118 | histone exchange (GO:0043486) | 2.87680704 |
| 119 | viral life cycle (GO:0019058) | 2.86825037 |
| 120 | protein deneddylation (GO:0000338) | 2.86666244 |
| 121 | telomere organization (GO:0032200) | 2.86241031 |
| 122 | telomere maintenance (GO:0000723) | 2.85244532 |
| 123 | protein localization to endoplasmic reticulum (GO:0070972) | 2.83502468 |
| 124 | mitotic G1 DNA damage checkpoint (GO:0031571) | 2.82304727 |
| 125 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.82159361 |
| 126 | cellular protein complex disassembly (GO:0043624) | 2.81627088 |
| 127 | negative regulation of chromosome segregation (GO:0051985) | 2.81488809 |
| 128 | termination of RNA polymerase II transcription (GO:0006369) | 2.80767413 |
| 129 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.80681770 |
| 130 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.80315137 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.14078038 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.49707069 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.92861830 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.07258188 |
| 5 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.05251744 |
| 6 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.04898574 |
| 7 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.99241364 |
| 8 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.93695822 |
| 9 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.93546003 |
| 10 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.89257610 |
| 11 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.82228000 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.78036477 |
| 13 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.75236597 |
| 14 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.72106866 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.44354093 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.38310098 |
| 17 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.36337160 |
| 18 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.27548479 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.26243774 |
| 20 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.25869653 |
| 21 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.18632182 |
| 22 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.04487483 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.01056390 |
| 24 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.93436827 |
| 25 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.88978848 |
| 26 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.85988514 |
| 27 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.85199379 |
| 28 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.83791333 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.83628898 |
| 30 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.82012837 |
| 31 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.80234091 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.75597046 |
| 33 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.74460296 |
| 34 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.74232028 |
| 35 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.70215147 |
| 36 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.68915904 |
| 37 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.68531749 |
| 38 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.68393171 |
| 39 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.67343384 |
| 40 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.65271855 |
| 41 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.64098220 |
| 42 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.61019426 |
| 43 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.60530630 |
| 44 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59905412 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.58283276 |
| 46 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.53624270 |
| 47 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.53262581 |
| 48 | MYC_22102868_ChIP-Seq_BL_Human | 1.53044616 |
| 49 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.45248140 |
| 50 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.42549526 |
| 51 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.40495835 |
| 52 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.38103718 |
| 53 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.34798558 |
| 54 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.34242485 |
| 55 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.33017623 |
| 56 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.31101865 |
| 57 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.31101865 |
| 58 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.31101865 |
| 59 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.30249324 |
| 60 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.28026746 |
| 61 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.27286195 |
| 62 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.26895862 |
| 63 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.24994064 |
| 64 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.24954591 |
| 65 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.24161697 |
| 66 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.23752661 |
| 67 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.23077507 |
| 68 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.21738538 |
| 69 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20804475 |
| 70 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.20607855 |
| 71 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.17443075 |
| 72 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.16199117 |
| 73 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.14634802 |
| 74 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.14001060 |
| 75 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.13680890 |
| 76 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.12630213 |
| 77 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.12130502 |
| 78 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.11162244 |
| 79 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.09961348 |
| 80 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.09552283 |
| 81 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.08574879 |
| 82 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.06869380 |
| 83 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.06157727 |
| 84 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.05482287 |
| 85 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.02049664 |
| 86 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.01354269 |
| 87 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.00381656 |
| 88 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.99915825 |
| 89 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.99340834 |
| 90 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99114818 |
| 91 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.98473182 |
| 92 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.98471356 |
| 93 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.98127820 |
| 94 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.97941494 |
| 95 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.97883078 |
| 96 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.97604827 |
| 97 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.97354048 |
| 98 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.96402551 |
| 99 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.95980162 |
| 100 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.94748458 |
| 101 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.94710947 |
| 102 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94276240 |
| 103 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.93995326 |
| 104 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.91920153 |
| 105 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.91841516 |
| 106 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.91629931 |
| 107 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.90063148 |
| 108 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.87719579 |
| 109 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.87338017 |
| 110 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.86931966 |
| 111 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.86094128 |
| 112 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.86089237 |
| 113 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.84630866 |
| 114 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.84566074 |
| 115 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.84420690 |
| 116 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.82375482 |
| 117 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.81521265 |
| 118 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.77272036 |
| 119 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.71015924 |
| 120 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.70497537 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.05184008 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.39577273 |
| 3 | MP0008057_abnormal_DNA_replication | 4.37889131 |
| 4 | MP0010094_abnormal_chromosome_stability | 4.32403943 |
| 5 | MP0003111_abnormal_nucleus_morphology | 4.04917213 |
| 6 | MP0003077_abnormal_cell_cycle | 3.64822790 |
| 7 | MP0008058_abnormal_DNA_repair | 3.26604200 |
| 8 | MP0003806_abnormal_nucleotide_metabolis | 3.20648693 |
| 9 | MP0009697_abnormal_copulation | 2.63613075 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.59539712 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.53320332 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.26051173 |
| 13 | MP0003786_premature_aging | 2.24475528 |
| 14 | MP0001730_embryonic_growth_arrest | 2.18382394 |
| 15 | MP0010352_gastrointestinal_tract_polyps | 2.02937630 |
| 16 | MP0002877_abnormal_melanocyte_morpholog | 2.02936646 |
| 17 | MP0003718_maternal_effect | 1.98703502 |
| 18 | MP0000350_abnormal_cell_proliferation | 1.98012401 |
| 19 | MP0003123_paternal_imprinting | 1.83938364 |
| 20 | MP0000490_abnormal_crypts_of | 1.83665468 |
| 21 | MP0004147_increased_porphyrin_level | 1.81596087 |
| 22 | MP0010030_abnormal_orbit_morphology | 1.78142514 |
| 23 | MP0003941_abnormal_skin_development | 1.78117727 |
| 24 | MP0008877_abnormal_DNA_methylation | 1.77999644 |
| 25 | MP0000372_irregular_coat_pigmentation | 1.73964186 |
| 26 | MP0001697_abnormal_embryo_size | 1.66997722 |
| 27 | MP0003186_abnormal_redox_activity | 1.62426979 |
| 28 | MP0004133_heterotaxia | 1.60869382 |
| 29 | * MP0005380_embryogenesis_phenotype | 1.59917622 |
| 30 | * MP0001672_abnormal_embryogenesis/_devel | 1.59917622 |
| 31 | * MP0002080_prenatal_lethality | 1.53159466 |
| 32 | MP0002653_abnormal_ependyma_morphology | 1.49838832 |
| 33 | MP0002085_abnormal_embryonic_tissue | 1.44673448 |
| 34 | MP0009379_abnormal_foot_pigmentation | 1.44393737 |
| 35 | MP0000313_abnormal_cell_death | 1.44302594 |
| 36 | MP0002019_abnormal_tumor_incidence | 1.43707276 |
| 37 | MP0003890_abnormal_embryonic-extraembry | 1.43026892 |
| 38 | MP0001545_abnormal_hematopoietic_system | 1.42391265 |
| 39 | MP0005397_hematopoietic_system_phenotyp | 1.42391265 |
| 40 | MP0003984_embryonic_growth_retardation | 1.40727068 |
| 41 | MP0001293_anophthalmia | 1.40348059 |
| 42 | MP0010307_abnormal_tumor_latency | 1.39552987 |
| 43 | MP0002088_abnormal_embryonic_growth/wei | 1.37882944 |
| 44 | MP0002084_abnormal_developmental_patter | 1.36352367 |
| 45 | MP0002086_abnormal_extraembryonic_tissu | 1.35276124 |
| 46 | MP0006036_abnormal_mitochondrial_physio | 1.34591994 |
| 47 | MP0006292_abnormal_olfactory_placode | 1.32706948 |
| 48 | MP0003567_abnormal_fetal_cardiomyocyte | 1.30290983 |
| 49 | MP0005075_abnormal_melanosome_morpholog | 1.29637868 |
| 50 | MP0004197_abnormal_fetal_growth/weight/ | 1.28069238 |
| 51 | MP0003315_abnormal_perineum_morphology | 1.20136343 |
| 52 | MP0002210_abnormal_sex_determination | 1.18245494 |
| 53 | MP0009333_abnormal_splenocyte_physiolog | 1.17826233 |
| 54 | MP0005266_abnormal_metabolism | 1.17773182 |
| 55 | MP0005501_abnormal_skin_physiology | 1.17575672 |
| 56 | MP0001661_extended_life_span | 1.14204751 |
| 57 | MP0003119_abnormal_digestive_system | 1.13136811 |
| 58 | MP0006035_abnormal_mitochondrial_morpho | 1.12927054 |
| 59 | MP0000358_abnormal_cell_content/ | 1.11813003 |
| 60 | MP0001145_abnormal_male_reproductive | 1.10793639 |
| 61 | MP0005408_hypopigmentation | 1.08916565 |
| 62 | MP0002938_white_spotting | 1.01585195 |
| 63 | MP0002132_abnormal_respiratory_system | 0.99594374 |
| 64 | MP0005451_abnormal_body_composition | 0.97129506 |
| 65 | MP0004808_abnormal_hematopoietic_stem | 0.97082556 |
| 66 | MP0003763_abnormal_thymus_physiology | 0.96504073 |
| 67 | MP0001881_abnormal_mammary_gland | 0.95946532 |
| 68 | MP0008995_early_reproductive_senescence | 0.95881436 |
| 69 | MP0000689_abnormal_spleen_morphology | 0.93117713 |
| 70 | MP0001764_abnormal_homeostasis | 0.92940213 |
| 71 | MP0001188_hyperpigmentation | 0.92562904 |
| 72 | MP0000653_abnormal_sex_gland | 0.91298994 |
| 73 | MP0001929_abnormal_gametogenesis | 0.90913598 |
| 74 | MP0002722_abnormal_immune_system | 0.90044806 |
| 75 | MP0000703_abnormal_thymus_morphology | 0.86253116 |
| 76 | MP0003221_abnormal_cardiomyocyte_apopto | 0.85826692 |
| 77 | MP0002111_abnormal_tail_morphology | 0.85376962 |
| 78 | MP0002163_abnormal_gland_morphology | 0.85008052 |
| 79 | MP0002269_muscular_atrophy | 0.82556252 |
| 80 | MP0009278_abnormal_bone_marrow | 0.82114629 |
| 81 | MP0003937_abnormal_limbs/digits/tail_de | 0.81601724 |
| 82 | MP0001119_abnormal_female_reproductive | 0.79702756 |
| 83 | MP0001853_heart_inflammation | 0.79646902 |
| 84 | MP0000678_abnormal_parathyroid_gland | 0.78872183 |
| 85 | MP0002398_abnormal_bone_marrow | 0.78229714 |
| 86 | MP0002160_abnormal_reproductive_system | 0.77210304 |
| 87 | MP0001529_abnormal_vocalization | 0.76968701 |
| 88 | MP0003656_abnormal_erythrocyte_physiolo | 0.75754520 |
| 89 | MP0005187_abnormal_penis_morphology | 0.74208117 |
| 90 | MP0008789_abnormal_olfactory_epithelium | 0.74179429 |
| 91 | MP0002796_impaired_skin_barrier | 0.73400685 |
| 92 | MP0002161_abnormal_fertility/fecundity | 0.71997315 |
| 93 | MP0005389_reproductive_system_phenotype | 0.71368227 |
| 94 | MP0009672_abnormal_birth_weight | 0.71358213 |
| 95 | * MP0000598_abnormal_liver_morphology | 0.70771438 |
| 96 | MP0000858_altered_metastatic_potential | 0.70503082 |
| 97 | MP0005023_abnormal_wound_healing | 0.70166215 |
| 98 | MP0000750_abnormal_muscle_regeneration | 0.68069422 |
| 99 | MP0002429_abnormal_blood_cell | 0.67275537 |
| 100 | MP0003698_abnormal_male_reproductive | 0.67272735 |
| 101 | MP0009840_abnormal_foam_cell | 0.65753788 |
| 102 | MP0000477_abnormal_intestine_morphology | 0.65740224 |
| 103 | MP0005384_cellular_phenotype | 0.65728611 |
| 104 | MP0002095_abnormal_skin_pigmentation | 0.64727313 |
| 105 | MP0001727_abnormal_embryo_implantation | 0.63996369 |
| 106 | MP0003646_muscle_fatigue | 0.63883071 |
| 107 | MP0004264_abnormal_extraembryonic_tissu | 0.63759468 |
| 108 | MP0005330_cardiomyopathy | 0.63534677 |
| 109 | MP0004185_abnormal_adipocyte_glucose | 0.63177126 |
| 110 | MP0005319_abnormal_enzyme/_coenzyme | 0.63133548 |
| 111 | MP0003136_yellow_coat_color | 0.62608280 |
| 112 | MP0005365_abnormal_bile_salt | 0.62344723 |
| 113 | MP0005085_abnormal_gallbladder_physiolo | 0.62002854 |
| 114 | MP0009053_abnormal_anal_canal | 0.61791469 |
| 115 | MP0002234_abnormal_pharynx_morphology | 0.61760651 |
| 116 | MP0005395_other_phenotype | 0.61305868 |
| 117 | MP0004233_abnormal_muscle_weight | 0.60926838 |
| 118 | MP0002332_abnormal_exercise_endurance | 0.59570438 |
| 119 | MP0005376_homeostasis/metabolism_phenot | 0.59066741 |
| 120 | MP0001919_abnormal_reproductive_system | 0.58081008 |
| 121 | MP0005076_abnormal_cell_differentiation | 0.56960432 |
| 122 | MP0003699_abnormal_female_reproductive | 0.55594344 |
| 123 | MP0002970_abnormal_white_adipose | 0.54949078 |
| 124 | MP0000627_abnormal_mammary_gland | 0.54722592 |
| 125 | MP0005332_abnormal_amino_acid | 0.54609775 |
| 126 | MP0005636_abnormal_mineral_homeostasis | 0.54189233 |
| 127 | MP0000049_abnormal_middle_ear | 0.54117455 |
| 128 | MP0003283_abnormal_digestive_organ | 0.54072333 |
| 129 | MP0005621_abnormal_cell_physiology | 0.52956578 |
| 130 | MP0002075_abnormal_coat/hair_pigmentati | 0.52936691 |
| 131 | MP0005410_abnormal_fertilization | 0.52212272 |
| 132 | MP0000371_diluted_coat_color | 0.52198262 |
| 133 | MP0002697_abnormal_eye_size | 0.51388680 |
| 134 | MP0003385_abnormal_body_wall | 0.51160510 |
| 135 | MP0009703_decreased_birth_body | 0.50807488 |
| 136 | MP0000647_abnormal_sebaceous_gland | 0.49795011 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.42454042 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 4.33198806 |
| 3 | Oral leukoplakia (HP:0002745) | 4.21280017 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 4.05550894 |
| 5 | Reticulocytopenia (HP:0001896) | 4.01738142 |
| 6 | Acute necrotizing encephalopathy (HP:0006965) | 3.72075075 |
| 7 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.71006396 |
| 8 | Acute encephalopathy (HP:0006846) | 3.69111226 |
| 9 | Selective tooth agenesis (HP:0001592) | 3.60062647 |
| 10 | Breast hypoplasia (HP:0003187) | 3.53022596 |
| 11 | Aplastic anemia (HP:0001915) | 3.37789783 |
| 12 | Increased CSF lactate (HP:0002490) | 3.34882785 |
| 13 | Carpal bone hypoplasia (HP:0001498) | 3.23622725 |
| 14 | Rough bone trabeculation (HP:0100670) | 3.20567932 |
| 15 | Mitochondrial inheritance (HP:0001427) | 3.15338662 |
| 16 | Colon cancer (HP:0003003) | 3.14266155 |
| 17 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 3.10333227 |
| 18 | Increased hepatocellular lipid droplets (HP:0006565) | 3.09847753 |
| 19 | Absent thumb (HP:0009777) | 3.08189895 |
| 20 | Cerebral hypomyelination (HP:0006808) | 3.07147914 |
| 21 | Degeneration of anterior horn cells (HP:0002398) | 3.05647401 |
| 22 | Abnormality of the anterior horn cell (HP:0006802) | 3.05647401 |
| 23 | Hepatocellular necrosis (HP:0001404) | 2.99713142 |
| 24 | Hepatic necrosis (HP:0002605) | 2.97284783 |
| 25 | Patellar aplasia (HP:0006443) | 2.96052957 |
| 26 | Lipid accumulation in hepatocytes (HP:0006561) | 2.89314289 |
| 27 | Ependymoma (HP:0002888) | 2.88180586 |
| 28 | Progressive macrocephaly (HP:0004481) | 2.88175936 |
| 29 | Cerebral edema (HP:0002181) | 2.88154068 |
| 30 | Premature graying of hair (HP:0002216) | 2.85607438 |
| 31 | Macrocytic anemia (HP:0001972) | 2.83839794 |
| 32 | Chromsome breakage (HP:0040012) | 2.83495540 |
| 33 | Absent radius (HP:0003974) | 2.80970458 |
| 34 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.80656416 |
| 35 | Abnormality of the ileum (HP:0001549) | 2.78963978 |
| 36 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.77457831 |
| 37 | Microretrognathia (HP:0000308) | 2.70401202 |
| 38 | Multiple enchondromatosis (HP:0005701) | 2.69745121 |
| 39 | Medulloblastoma (HP:0002885) | 2.68426459 |
| 40 | Pallor (HP:0000980) | 2.65328922 |
| 41 | Lactic acidosis (HP:0003128) | 2.65311603 |
| 42 | Meckel diverticulum (HP:0002245) | 2.60572465 |
| 43 | Aplasia involving forearm bones (HP:0009822) | 2.59212676 |
| 44 | Absent forearm bone (HP:0003953) | 2.59212676 |
| 45 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.56919763 |
| 46 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.56919763 |
| 47 | Abnormal protein glycosylation (HP:0012346) | 2.56919763 |
| 48 | Abnormal glycosylation (HP:0012345) | 2.56919763 |
| 49 | Abnormality of the preputium (HP:0100587) | 2.56600104 |
| 50 | Short middle phalanx of the 5th finger (HP:0004220) | 2.56233938 |
| 51 | Increased intramyocellular lipid droplets (HP:0012240) | 2.54941837 |
| 52 | Squamous cell carcinoma (HP:0002860) | 2.54217076 |
| 53 | Rhabdomyosarcoma (HP:0002859) | 2.54034887 |
| 54 | Progressive muscle weakness (HP:0003323) | 2.53527788 |
| 55 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.52406285 |
| 56 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.52406285 |
| 57 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.51256447 |
| 58 | Trismus (HP:0000211) | 2.51037922 |
| 59 | Premature ovarian failure (HP:0008209) | 2.48835024 |
| 60 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.47096290 |
| 61 | Supernumerary spleens (HP:0009799) | 2.46314909 |
| 62 | Rectal fistula (HP:0100590) | 2.42867863 |
| 63 | Rectovaginal fistula (HP:0000143) | 2.42867863 |
| 64 | Impulsivity (HP:0100710) | 2.41914480 |
| 65 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.38783097 |
| 66 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.38783097 |
| 67 | Single umbilical artery (HP:0001195) | 2.38783097 |
| 68 | Myelodysplasia (HP:0002863) | 2.37959025 |
| 69 | Abnormality of chromosome stability (HP:0003220) | 2.37544158 |
| 70 | Abnormality of alanine metabolism (HP:0010916) | 2.37228883 |
| 71 | Hyperalaninemia (HP:0003348) | 2.37228883 |
| 72 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.37228883 |
| 73 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.34446821 |
| 74 | Renal Fanconi syndrome (HP:0001994) | 2.33845186 |
| 75 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.33646940 |
| 76 | Abnormality of methionine metabolism (HP:0010901) | 2.33076255 |
| 77 | Rib fusion (HP:0000902) | 2.31954963 |
| 78 | Basal cell carcinoma (HP:0002671) | 2.30646952 |
| 79 | Pancytopenia (HP:0001876) | 2.29282948 |
| 80 | Cellular immunodeficiency (HP:0005374) | 2.29123847 |
| 81 | Neoplasm of the pancreas (HP:0002894) | 2.28730256 |
| 82 | Type I transferrin isoform profile (HP:0003642) | 2.27040192 |
| 83 | Exercise intolerance (HP:0003546) | 2.26067534 |
| 84 | Secondary amenorrhea (HP:0000869) | 2.25949487 |
| 85 | Increased serum lactate (HP:0002151) | 2.24667047 |
| 86 | Respiratory difficulties (HP:0002880) | 2.24639512 |
| 87 | Abnormal number of incisors (HP:0011064) | 2.23171610 |
| 88 | Bone marrow hypocellularity (HP:0005528) | 2.22042041 |
| 89 | Poikiloderma (HP:0001029) | 2.21583483 |
| 90 | Muscle fiber atrophy (HP:0100295) | 2.19231421 |
| 91 | Vaginal fistula (HP:0004320) | 2.17135124 |
| 92 | Abnormal trabecular bone morphology (HP:0100671) | 2.16184792 |
| 93 | Agnosia (HP:0010524) | 2.15448025 |
| 94 | Tongue fasciculations (HP:0001308) | 2.15035732 |
| 95 | Megaloblastic anemia (HP:0001889) | 2.12416297 |
| 96 | Increased muscle lipid content (HP:0009058) | 2.11998116 |
| 97 | Testicular atrophy (HP:0000029) | 2.10117401 |
| 98 | Microvesicular hepatic steatosis (HP:0001414) | 2.09948993 |
| 99 | Abnormality of the umbilical cord (HP:0010881) | 2.09187876 |
| 100 | Respiratory failure (HP:0002878) | 2.07636169 |
| 101 | Sparse eyelashes (HP:0000653) | 2.06664608 |
| 102 | Abdominal situs inversus (HP:0003363) | 2.05355251 |
| 103 | Abnormality of abdominal situs (HP:0011620) | 2.05355251 |
| 104 | Ragged-red muscle fibers (HP:0003200) | 2.03087456 |
| 105 | Type 2 muscle fiber atrophy (HP:0003554) | 2.02310166 |
| 106 | Small intestinal stenosis (HP:0012848) | 2.00729243 |
| 107 | Duodenal stenosis (HP:0100867) | 2.00729243 |
| 108 | Abnormality of serum amino acid levels (HP:0003112) | 2.00721415 |
| 109 | Abnormal gallbladder physiology (HP:0012438) | 2.00718553 |
| 110 | Cholecystitis (HP:0001082) | 2.00718553 |
| 111 | Intestinal fistula (HP:0100819) | 2.00334831 |
| 112 | Facial hemangioma (HP:0000329) | 1.97051396 |
| 113 | Horseshoe kidney (HP:0000085) | 1.96839439 |
| 114 | Abnormality of the labia minora (HP:0012880) | 1.92785016 |
| 115 | Abnormal lung lobation (HP:0002101) | 1.92747241 |
| 116 | Hypoplasia of the radius (HP:0002984) | 1.92109542 |
| 117 | Muscle fibrillation (HP:0010546) | 1.91348943 |
| 118 | Tracheoesophageal fistula (HP:0002575) | 1.88298704 |
| 119 | Sloping forehead (HP:0000340) | 1.87903653 |
| 120 | 11 pairs of ribs (HP:0000878) | 1.87221865 |
| 121 | Hyperglycinemia (HP:0002154) | 1.87070125 |
| 122 | Asplenia (HP:0001746) | 1.86722323 |
| 123 | Gout (HP:0001997) | 1.85245417 |
| 124 | Abnormality of the carotid arteries (HP:0005344) | 1.85087323 |
| 125 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.84734537 |
| 126 | Increased nuchal translucency (HP:0010880) | 1.84490596 |
| 127 | Lethargy (HP:0001254) | 1.84227457 |
| 128 | Short humerus (HP:0005792) | 1.83880076 |
| 129 | Cleft eyelid (HP:0000625) | 1.83663713 |
| 130 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.83314779 |
| 131 | Leukodystrophy (HP:0002415) | 1.82999189 |
| 132 | Triphalangeal thumb (HP:0001199) | 1.77686692 |
| 133 | Abnormal hemoglobin (HP:0011902) | 1.77650987 |
| 134 | Neoplasm of striated muscle (HP:0009728) | 1.77313865 |
| 135 | Lymphoma (HP:0002665) | 1.75946109 |
| 136 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.75890366 |
| 137 | Increased serum pyruvate (HP:0003542) | 1.75679108 |
| 138 | Abnormality of glycolysis (HP:0004366) | 1.75679108 |
| 139 | Facial cleft (HP:0002006) | 1.75574014 |
| 140 | Nausea (HP:0002018) | 1.75464800 |
| 141 | Abnormality of reticulocytes (HP:0004312) | 1.75447165 |
| 142 | Abnormality of the duodenum (HP:0002246) | 1.74837479 |
| 143 | Hypoglycemic coma (HP:0001325) | 1.74415833 |
| 144 | Reduced antithrombin III activity (HP:0001976) | 1.74368856 |
| 145 | 3-Methylglutaconic aciduria (HP:0003535) | 1.73870533 |
| 146 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.73406333 |
| 147 | Proximal placement of thumb (HP:0009623) | 1.72068718 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.52685620 |
| 2 | WEE1 | 4.29758569 |
| 3 | EIF2AK1 | 3.58140158 |
| 4 | CDC7 | 3.48271273 |
| 5 | VRK2 | 3.16772238 |
| 6 | NME2 | 2.46116841 |
| 7 | STK16 | 2.26686794 |
| 8 | EIF2AK3 | 2.21988944 |
| 9 | NEK1 | 2.15327306 |
| 10 | CDK7 | 2.13473686 |
| 11 | NEK2 | 2.13305533 |
| 12 | TTK | 2.10876685 |
| 13 | SRPK1 | 2.06228353 |
| 14 | PLK4 | 2.05974432 |
| 15 | PLK1 | 2.05763584 |
| 16 | BRSK2 | 2.00767210 |
| 17 | TSSK6 | 2.00187422 |
| 18 | PDK2 | 1.96922625 |
| 19 | TESK2 | 1.96327000 |
| 20 | BCKDK | 1.86031433 |
| 21 | DYRK3 | 1.84860620 |
| 22 | ACVR1B | 1.84777615 |
| 23 | RPS6KB2 | 1.75413562 |
| 24 | MAP3K11 | 1.67434449 |
| 25 | TRIM28 | 1.66258564 |
| 26 | MST4 | 1.60074171 |
| 27 | VRK1 | 1.56644019 |
| 28 | EPHA2 | 1.55965083 |
| 29 | ATR | 1.53511138 |
| 30 | PIM2 | 1.52101083 |
| 31 | AURKB | 1.51897800 |
| 32 | SCYL2 | 1.43464988 |
| 33 | CHEK2 | 1.42775601 |
| 34 | PASK | 1.39562774 |
| 35 | KDR | 1.38587794 |
| 36 | MKNK1 | 1.37145051 |
| 37 | AURKA | 1.36743276 |
| 38 | TLK1 | 1.33148151 |
| 39 | FLT3 | 1.22510429 |
| 40 | NUAK1 | 1.20373440 |
| 41 | CDK4 | 1.18739692 |
| 42 | MAP3K8 | 1.18328884 |
| 43 | CDK12 | 1.17586591 |
| 44 | BRSK1 | 1.16539428 |
| 45 | PAK4 | 1.16335079 |
| 46 | TAF1 | 1.10844456 |
| 47 | RPS6KA4 | 1.08919690 |
| 48 | PLK3 | 1.08360216 |
| 49 | SMG1 | 1.07553361 |
| 50 | MAP3K6 | 1.06649356 |
| 51 | PIM1 | 0.99658281 |
| 52 | CHEK1 | 0.98443687 |
| 53 | STK10 | 0.97996747 |
| 54 | ICK | 0.94543902 |
| 55 | ARAF | 0.93259007 |
| 56 | MKNK2 | 0.92641380 |
| 57 | EIF2AK2 | 0.88891396 |
| 58 | STK4 | 0.87819118 |
| 59 | MAPKAPK3 | 0.87371019 |
| 60 | TGFBR1 | 0.87001322 |
| 61 | MATK | 0.86416365 |
| 62 | MAP2K3 | 0.85989151 |
| 63 | CLK1 | 0.84296818 |
| 64 | EEF2K | 0.83442758 |
| 65 | CSNK2A1 | 0.81492047 |
| 66 | CSNK1G3 | 0.80538741 |
| 67 | CDK6 | 0.80389432 |
| 68 | DAPK1 | 0.78817333 |
| 69 | ZAK | 0.77235803 |
| 70 | CSNK2A2 | 0.76614344 |
| 71 | CDK2 | 0.75601770 |
| 72 | CDK8 | 0.72601405 |
| 73 | TAOK2 | 0.71038975 |
| 74 | MAP3K10 | 0.70937307 |
| 75 | ATM | 0.70316569 |
| 76 | YES1 | 0.67824146 |
| 77 | RAF1 | 0.64957152 |
| 78 | ILK | 0.63711559 |
| 79 | CSNK1G1 | 0.63607102 |
| 80 | PINK1 | 0.63327230 |
| 81 | STK3 | 0.60902312 |
| 82 | PAK1 | 0.60644270 |
| 83 | MAP4K1 | 0.58346522 |
| 84 | CCNB1 | 0.57373837 |
| 85 | ALK | 0.56380412 |
| 86 | DDR2 | 0.56282491 |
| 87 | BMPR1B | 0.56250634 |
| 88 | IRAK3 | 0.55900586 |
| 89 | MAPK11 | 0.55484745 |
| 90 | DYRK2 | 0.55411429 |
| 91 | CSNK1A1L | 0.54810766 |
| 92 | LATS2 | 0.50916305 |
| 93 | MAPK15 | 0.49948701 |
| 94 | BLK | 0.49894005 |
| 95 | TESK1 | 0.48756306 |
| 96 | PRKCI | 0.48195300 |
| 97 | LRRK2 | 0.47690599 |
| 98 | CDK1 | 0.47651957 |
| 99 | CSNK1E | 0.46016708 |
| 100 | MST1R | 0.44622951 |
| 101 | BRAF | 0.43243141 |
| 102 | CSNK1G2 | 0.42028928 |
| 103 | AKT2 | 0.41685142 |
| 104 | MAPKAPK5 | 0.40866800 |
| 105 | ERBB4 | 0.40556432 |
| 106 | MTOR | 0.40169471 |
| 107 | DYRK1B | 0.40031639 |
| 108 | PBK | 0.39522088 |
| 109 | CDK9 | 0.38652882 |
| 110 | MAP2K6 | 0.35370392 |
| 111 | ABL2 | 0.35304920 |
| 112 | CDK3 | 0.34322650 |
| 113 | NME1 | 0.32468389 |
| 114 | BTK | 0.32348628 |
| 115 | GRK6 | 0.32000800 |
| 116 | ZAP70 | 0.31891784 |
| 117 | CDK11A | 0.31579432 |
| 118 | CDK14 | 0.31422508 |
| 119 | PDK3 | 0.31241522 |
| 120 | PDK4 | 0.31241522 |
| 121 | RPS6KA5 | 0.30553106 |
| 122 | PRKDC | 0.30317841 |
| 123 | CDK18 | 0.30290478 |
| 124 | PLK2 | 0.29870229 |
| 125 | MAP3K12 | 0.29735666 |
| 126 | RPS6KL1 | 0.28313361 |
| 127 | RPS6KC1 | 0.28313361 |
| 128 | MAP4K2 | 0.28310169 |
| 129 | STK38L | 0.28113699 |
| 130 | WNK4 | 0.27476900 |
| 131 | CDK15 | 0.27431696 |
| 132 | STK24 | 0.27005484 |
| 133 | RPS6KA6 | 0.25000617 |
| 134 | BCR | 0.24986995 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.02809330 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.44414073 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.53874323 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.53630562 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 3.39794303 |
| 6 | Base excision repair_Homo sapiens_hsa03410 | 3.17500043 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.03935226 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.95467170 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.84311500 |
| 10 | RNA transport_Homo sapiens_hsa03013 | 2.83905747 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.82625045 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.81756673 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.43030841 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.28669953 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.17287419 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.00599685 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.67707074 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.58400353 |
| 19 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.56079890 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.53131565 |
| 21 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.43817974 |
| 22 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.41115548 |
| 23 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.39572417 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.35736197 |
| 25 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.32866027 |
| 26 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.31711064 |
| 27 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.22505286 |
| 28 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.21452157 |
| 29 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.20274677 |
| 30 | Sulfur relay system_Homo sapiens_hsa04122 | 1.20098806 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.19146229 |
| 32 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.16452318 |
| 33 | Alzheimers disease_Homo sapiens_hsa05010 | 1.16091922 |
| 34 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.10646773 |
| 35 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.04754568 |
| 36 | Carbon metabolism_Homo sapiens_hsa01200 | 0.96261182 |
| 37 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.91370315 |
| 38 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.90440598 |
| 39 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.89902746 |
| 40 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.89430061 |
| 41 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.86222718 |
| 42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.85023513 |
| 43 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.84801739 |
| 44 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.84205544 |
| 45 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.78281766 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.76890172 |
| 47 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.74939109 |
| 48 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.71816606 |
| 49 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.68828120 |
| 50 | Galactose metabolism_Homo sapiens_hsa00052 | 0.66439751 |
| 51 | Huntingtons disease_Homo sapiens_hsa05016 | 0.64652200 |
| 52 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.63746085 |
| 53 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.62952044 |
| 54 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.62083584 |
| 55 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.61877889 |
| 56 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.61013184 |
| 57 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.59354415 |
| 58 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.58556125 |
| 59 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.58112961 |
| 60 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.57948622 |
| 61 | Parkinsons disease_Homo sapiens_hsa05012 | 0.56926349 |
| 62 | Protein export_Homo sapiens_hsa03060 | 0.55204139 |
| 63 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.52321519 |
| 64 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.52083938 |
| 65 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.51829812 |
| 66 | Thyroid cancer_Homo sapiens_hsa05216 | 0.51544574 |
| 67 | Legionellosis_Homo sapiens_hsa05134 | 0.51389984 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.46464570 |
| 69 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.44647638 |
| 70 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.42782772 |
| 71 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.42246771 |
| 72 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.41623424 |
| 73 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.38313906 |
| 74 | HTLV-I infection_Homo sapiens_hsa05166 | 0.38148818 |
| 75 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.36300949 |
| 76 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.36010300 |
| 77 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.35393690 |
| 78 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.32568883 |
| 79 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.30894967 |
| 80 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.30268342 |
| 81 | Bladder cancer_Homo sapiens_hsa05219 | 0.29364240 |
| 82 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.29015483 |
| 83 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.27884979 |
| 84 | Peroxisome_Homo sapiens_hsa04146 | 0.26754690 |
| 85 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.26652731 |
| 86 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.24954845 |
| 87 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.24642584 |
| 88 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.21956305 |
| 89 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.21547261 |
| 90 | Shigellosis_Homo sapiens_hsa05131 | 0.21296981 |
| 91 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.21158067 |
| 92 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.20835725 |
| 93 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.20633732 |
| 94 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.20617668 |
| 95 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.20421477 |
| 96 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.20170973 |
| 97 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.19525362 |
| 98 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.19260518 |
| 99 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.18440933 |
| 100 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.16768488 |
| 101 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.16706609 |
| 102 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.16522221 |
| 103 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.15764750 |
| 104 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.14762117 |
| 105 | Apoptosis_Homo sapiens_hsa04210 | 0.14402848 |
| 106 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.14233514 |
| 107 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.14143846 |
| 108 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.14082815 |
| 109 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.14045730 |
| 110 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.14017025 |
| 111 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.13501249 |
| 112 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.13211370 |
| 113 | Lysine degradation_Homo sapiens_hsa00310 | 0.13165257 |
| 114 | Alcoholism_Homo sapiens_hsa05034 | 0.12474249 |
| 115 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.10009010 |
| 116 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.02139865 |
| 117 | Vibrio cholerae infection_Homo sapiens_hsa05110 | -0.0085476 |

