

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.63362284 |
| 2 | DNA deamination (GO:0045006) | 5.47744926 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 4.74166659 |
| 4 | viral transcription (GO:0019083) | 4.70754573 |
| 5 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.65345139 |
| 6 | translational termination (GO:0006415) | 4.62593598 |
| 7 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.61895171 |
| 8 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.59354864 |
| 9 | ribosomal small subunit biogenesis (GO:0042274) | 4.57525784 |
| 10 | DNA strand elongation (GO:0022616) | 4.40886689 |
| 11 | formation of translation preinitiation complex (GO:0001731) | 4.34853754 |
| 12 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.34563630 |
| 13 | * proteasome assembly (GO:0043248) | 4.29185234 |
| 14 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.27446780 |
| 15 | ribosomal large subunit biogenesis (GO:0042273) | 4.24873518 |
| 16 | translational elongation (GO:0006414) | 4.24700555 |
| 17 | DNA replication initiation (GO:0006270) | 4.23243224 |
| 18 | cotranslational protein targeting to membrane (GO:0006613) | 4.20662597 |
| 19 | CENP-A containing nucleosome assembly (GO:0034080) | 4.18535790 |
| 20 | telomere maintenance via recombination (GO:0000722) | 4.17274922 |
| 21 | protein targeting to ER (GO:0045047) | 4.15604283 |
| 22 | DNA replication checkpoint (GO:0000076) | 4.10810324 |
| 23 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.08564384 |
| 24 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.07207938 |
| 25 | termination of RNA polymerase III transcription (GO:0006386) | 4.07207938 |
| 26 | chromatin remodeling at centromere (GO:0031055) | 4.05381388 |
| 27 | chaperone-mediated protein transport (GO:0072321) | 4.04879195 |
| 28 | nucleobase biosynthetic process (GO:0046112) | 4.02882739 |
| 29 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.99714435 |
| 30 | protein localization to endoplasmic reticulum (GO:0070972) | 3.98586430 |
| 31 | translational initiation (GO:0006413) | 3.94010920 |
| 32 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.93481725 |
| 33 | mitotic recombination (GO:0006312) | 3.86401604 |
| 34 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.83925151 |
| 35 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.83567579 |
| 36 | cullin deneddylation (GO:0010388) | 3.81372974 |
| 37 | purine nucleobase biosynthetic process (GO:0009113) | 3.80751430 |
| 38 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.76086509 |
| 39 | establishment of integrated proviral latency (GO:0075713) | 3.74647347 |
| 40 | negative regulation of ligase activity (GO:0051352) | 3.73063619 |
| 41 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.73063619 |
| 42 | ribosome biogenesis (GO:0042254) | 3.72966331 |
| 43 | pseudouridine synthesis (GO:0001522) | 3.72544462 |
| 44 | protein neddylation (GO:0045116) | 3.71831718 |
| 45 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.71709485 |
| 46 | translation (GO:0006412) | 3.70332122 |
| 47 | DNA strand renaturation (GO:0000733) | 3.68322136 |
| 48 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.66959286 |
| 49 | cellular protein complex disassembly (GO:0043624) | 3.66768959 |
| 50 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.65617316 |
| 51 | rRNA processing (GO:0006364) | 3.65347044 |
| 52 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.65007114 |
| 53 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.64761496 |
| 54 | protein deneddylation (GO:0000338) | 3.64710360 |
| 55 | viral life cycle (GO:0019058) | 3.64498588 |
| 56 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.62846213 |
| 57 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.62846213 |
| 58 | telomere maintenance via telomere lengthening (GO:0010833) | 3.62830311 |
| 59 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.62560711 |
| 60 | DNA replication-independent nucleosome organization (GO:0034724) | 3.62560711 |
| 61 | spliceosomal snRNP assembly (GO:0000387) | 3.62524453 |
| 62 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.60673126 |
| 63 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.60673126 |
| 64 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.60673126 |
| 65 | 7-methylguanosine mRNA capping (GO:0006370) | 3.60521529 |
| 66 | DNA double-strand break processing (GO:0000729) | 3.57224676 |
| 67 | protein complex biogenesis (GO:0070271) | 3.55889905 |
| 68 | RNA capping (GO:0036260) | 3.55465552 |
| 69 | 7-methylguanosine RNA capping (GO:0009452) | 3.55465552 |
| 70 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.54631663 |
| 71 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.52014220 |
| 72 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.52014220 |
| 73 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.51872656 |
| 74 | rRNA metabolic process (GO:0016072) | 3.51195756 |
| 75 | regulation of mitochondrial translation (GO:0070129) | 3.50807664 |
| 76 | rRNA modification (GO:0000154) | 3.50133832 |
| 77 | kinetochore organization (GO:0051383) | 3.50046941 |
| 78 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.47599594 |
| 79 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.45928717 |
| 80 | cellular component biogenesis (GO:0044085) | 3.45494083 |
| 81 | respiratory electron transport chain (GO:0022904) | 3.43399004 |
| 82 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.41816906 |
| 83 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.40999857 |
| 84 | ATP synthesis coupled proton transport (GO:0015986) | 3.40999857 |
| 85 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.39501337 |
| 86 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.38470389 |
| 87 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.38470389 |
| 88 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.37288070 |
| 89 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.35891456 |
| 90 | kinetochore assembly (GO:0051382) | 3.35499996 |
| 91 | protein targeting to mitochondrion (GO:0006626) | 3.34837184 |
| 92 | electron transport chain (GO:0022900) | 3.34652357 |
| 93 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.33882734 |
| 94 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.32077585 |
| 95 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.31969867 |
| 96 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.31969867 |
| 97 | NADH dehydrogenase complex assembly (GO:0010257) | 3.31969867 |
| 98 | mitotic metaphase plate congression (GO:0007080) | 3.30453241 |
| 99 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.29951971 |
| 100 | viral mRNA export from host cell nucleus (GO:0046784) | 3.29499461 |
| 101 | platelet dense granule organization (GO:0060155) | 3.29439921 |
| 102 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.29143234 |
| 103 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.29143234 |
| 104 | rRNA methylation (GO:0031167) | 3.28872629 |
| 105 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.28550878 |
| 106 | ribosome assembly (GO:0042255) | 3.28510901 |
| 107 | DNA unwinding involved in DNA replication (GO:0006268) | 3.28173677 |
| 108 | histone exchange (GO:0043486) | 3.25555704 |
| 109 | regulation of ligase activity (GO:0051340) | 3.24878383 |
| 110 | termination of RNA polymerase I transcription (GO:0006363) | 3.24495830 |
| 111 | cell cycle G1/S phase transition (GO:0044843) | 3.23563132 |
| 112 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.23563132 |
| 113 | piRNA metabolic process (GO:0034587) | 3.23509022 |
| 114 | protein complex disassembly (GO:0043241) | 3.23094101 |
| 115 | protein K11-linked ubiquitination (GO:0070979) | 3.20982238 |
| 116 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.20559912 |
| 117 | positive regulation of ligase activity (GO:0051351) | 3.17904572 |
| 118 | spliceosomal complex assembly (GO:0000245) | 3.17508498 |
| 119 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.17257223 |
| 120 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.13767867 |
| 121 | macromolecular complex disassembly (GO:0032984) | 3.12696104 |
| 122 | negative regulation of protein ubiquitination (GO:0031397) | 3.12287544 |
| 123 | IMP biosynthetic process (GO:0006188) | 3.12265787 |
| 124 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.11933211 |
| 125 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.10170753 |
| 126 | protein localization to mitochondrion (GO:0070585) | 3.07599270 |
| 127 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.06736887 |
| 128 | respiratory chain complex IV assembly (GO:0008535) | 3.04626134 |
| 129 | cytochrome complex assembly (GO:0017004) | 3.03759850 |
| 130 | synapsis (GO:0007129) | 3.03179261 |
| 131 | establishment of protein localization to mitochondrion (GO:0072655) | 3.01817046 |
| 132 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.01613475 |
| 133 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.00438709 |
| 134 | protein K6-linked ubiquitination (GO:0085020) | 2.98433325 |
| 135 | inner mitochondrial membrane organization (GO:0007007) | 2.96987518 |
| 136 | positive regulation of cell cycle arrest (GO:0071158) | 2.94982336 |
| 137 | replication fork processing (GO:0031297) | 2.87714244 |
| 138 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.87345760 |
| 139 | isotype switching (GO:0045190) | 2.84882075 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.67551463 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.57815883 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.35912340 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.05711558 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.81969399 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.79594422 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.71477450 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.40321599 |
| 9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.27084356 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.19269544 |
| 11 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.17846692 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.08593285 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.07406993 |
| 14 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.96269489 |
| 15 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.93089926 |
| 16 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.76374369 |
| 17 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.76223535 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.71850103 |
| 19 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.71007369 |
| 20 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.70327724 |
| 21 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.69033072 |
| 22 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.63497781 |
| 23 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.50160463 |
| 24 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.47246872 |
| 25 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.39675759 |
| 26 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.37827548 |
| 27 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.37544331 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.31870990 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.30235741 |
| 30 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.29280526 |
| 31 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.25727641 |
| 32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.14236120 |
| 33 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.13158392 |
| 34 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.05477888 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.03900733 |
| 36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.01629472 |
| 37 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.98333200 |
| 38 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.97728910 |
| 39 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.95966065 |
| 40 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.95470363 |
| 41 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.87318588 |
| 42 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.84390588 |
| 43 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.83877073 |
| 44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.82664824 |
| 45 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.73260608 |
| 46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.71953911 |
| 47 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.71660019 |
| 48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.70545877 |
| 49 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.69103815 |
| 50 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.67933549 |
| 51 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.65886128 |
| 52 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.60449012 |
| 53 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59959790 |
| 54 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.56546738 |
| 55 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.52958993 |
| 56 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.50196888 |
| 57 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.46839967 |
| 58 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.46795060 |
| 59 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35179726 |
| 60 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.34422547 |
| 61 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.29018058 |
| 62 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.25725724 |
| 63 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.24407797 |
| 64 | EWS_26573619_Chip-Seq_HEK293_Human | 1.23819781 |
| 65 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.23373142 |
| 66 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.20574613 |
| 67 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.19991603 |
| 68 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.18897193 |
| 69 | VDR_22108803_ChIP-Seq_LS180_Human | 1.15233455 |
| 70 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.13145999 |
| 71 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.12149943 |
| 72 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.11486809 |
| 73 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.10806874 |
| 74 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10625259 |
| 75 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.08101763 |
| 76 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.06582091 |
| 77 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.06207570 |
| 78 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.04859865 |
| 79 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.04763161 |
| 80 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.04089051 |
| 81 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.01938438 |
| 82 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.01010364 |
| 83 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99397197 |
| 84 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.98118540 |
| 85 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.95400789 |
| 86 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.93755046 |
| 87 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.91008439 |
| 88 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.90688117 |
| 89 | * TP53_22573176_ChIP-Seq_HFKS_Human | 0.90584853 |
| 90 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.90015023 |
| 91 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.88355377 |
| 92 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.87519812 |
| 93 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.87146997 |
| 94 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.85639131 |
| 95 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.85299331 |
| 96 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.83690268 |
| 97 | * ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.83493334 |
| 98 | FUS_26573619_Chip-Seq_HEK293_Human | 0.81788961 |
| 99 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.81337335 |
| 100 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.80158272 |
| 101 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.79651672 |
| 102 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.78864247 |
| 103 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.78132072 |
| 104 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.77999841 |
| 105 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.77866304 |
| 106 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.77101792 |
| 107 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.75653785 |
| 108 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.74754755 |
| 109 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.74055265 |
| 110 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.74055265 |
| 111 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.73467415 |
| 112 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.73447020 |
| 113 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.72283111 |
| 114 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.71307258 |
| 115 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.71077464 |
| 116 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.70437748 |
| 117 | MYC_22102868_ChIP-Seq_BL_Human | 0.68207644 |
| 118 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.67103980 |
| 119 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.64812727 |
| 120 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.64272181 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.62480012 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.67134445 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.55896573 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.06763137 |
| 5 | MP0008057_abnormal_DNA_replication | 4.01489838 |
| 6 | MP0003077_abnormal_cell_cycle | 3.88753451 |
| 7 | MP0008058_abnormal_DNA_repair | 3.85136318 |
| 8 | MP0008007_abnormal_cellular_replicative | 3.13381039 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.87078455 |
| 10 | MP0002396_abnormal_hematopoietic_system | 2.80288089 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.79313050 |
| 12 | MP0003786_premature_aging | 2.76863601 |
| 13 | MP0003806_abnormal_nucleotide_metabolis | 2.65269475 |
| 14 | MP0009379_abnormal_foot_pigmentation | 2.63178132 |
| 15 | MP0001835_abnormal_antigen_presentation | 2.28019473 |
| 16 | MP0003123_paternal_imprinting | 2.16268291 |
| 17 | MP0006292_abnormal_olfactory_placode | 2.15897788 |
| 18 | MP0006036_abnormal_mitochondrial_physio | 2.04525015 |
| 19 | MP0004147_increased_porphyrin_level | 2.03708400 |
| 20 | MP0003186_abnormal_redox_activity | 1.99387904 |
| 21 | MP0006054_spinal_hemorrhage | 1.89385181 |
| 22 | MP0002837_dystrophic_cardiac_calcinosis | 1.81061839 |
| 23 | MP0001730_embryonic_growth_arrest | 1.78309774 |
| 24 | MP0000490_abnormal_crypts_of | 1.70994062 |
| 25 | MP0003718_maternal_effect | 1.64944517 |
| 26 | MP0009697_abnormal_copulation | 1.62294123 |
| 27 | MP0000350_abnormal_cell_proliferation | 1.61500366 |
| 28 | MP0002132_abnormal_respiratory_system | 1.57437843 |
| 29 | MP0003763_abnormal_thymus_physiology | 1.57236305 |
| 30 | MP0005075_abnormal_melanosome_morpholog | 1.51692845 |
| 31 | MP0009333_abnormal_splenocyte_physiolog | 1.50177608 |
| 32 | MP0006035_abnormal_mitochondrial_morpho | 1.48076605 |
| 33 | MP0000313_abnormal_cell_death | 1.44811073 |
| 34 | MP0002006_tumorigenesis | 1.41205762 |
| 35 | MP0004808_abnormal_hematopoietic_stem | 1.34348649 |
| 36 | MP0005397_hematopoietic_system_phenotyp | 1.34135127 |
| 37 | MP0001545_abnormal_hematopoietic_system | 1.34135127 |
| 38 | MP0001529_abnormal_vocalization | 1.33626995 |
| 39 | MP0002019_abnormal_tumor_incidence | 1.33079495 |
| 40 | MP0001697_abnormal_embryo_size | 1.31126173 |
| 41 | MP0002080_prenatal_lethality | 1.28844456 |
| 42 | MP0003656_abnormal_erythrocyte_physiolo | 1.28776204 |
| 43 | MP0002166_altered_tumor_susceptibility | 1.28186894 |
| 44 | MP0005377_hearing/vestibular/ear_phenot | 1.25190079 |
| 45 | MP0003878_abnormal_ear_physiology | 1.25190079 |
| 46 | MP0008875_abnormal_xenobiotic_pharmacok | 1.24872213 |
| 47 | MP0001188_hyperpigmentation | 1.22583063 |
| 48 | MP0003315_abnormal_perineum_morphology | 1.22102798 |
| 49 | MP0001853_heart_inflammation | 1.19388319 |
| 50 | MP0002163_abnormal_gland_morphology | 1.18128124 |
| 51 | MP0002210_abnormal_sex_determination | 1.17878300 |
| 52 | MP0001764_abnormal_homeostasis | 1.15831613 |
| 53 | MP0002148_abnormal_hypersensitivity_rea | 1.15499120 |
| 54 | MP0003195_calcinosis | 1.15338809 |
| 55 | MP0005380_embryogenesis_phenotype | 1.13083239 |
| 56 | MP0001672_abnormal_embryogenesis/_devel | 1.13083239 |
| 57 | MP0003011_delayed_dark_adaptation | 1.12035084 |
| 58 | MP0000358_abnormal_cell_content/ | 1.11069396 |
| 59 | MP0002095_abnormal_skin_pigmentation | 1.10738890 |
| 60 | MP0001145_abnormal_male_reproductive | 1.08107609 |
| 61 | MP0003567_abnormal_fetal_cardiomyocyte | 1.07326546 |
| 62 | MP0000685_abnormal_immune_system | 1.06123455 |
| 63 | MP0002398_abnormal_bone_marrow | 1.05297819 |
| 64 | MP0002160_abnormal_reproductive_system | 1.03501260 |
| 65 | MP0000703_abnormal_thymus_morphology | 1.03370827 |
| 66 | MP0003984_embryonic_growth_retardation | 1.02115579 |
| 67 | MP0001929_abnormal_gametogenesis | 1.01144119 |
| 68 | MP0005379_endocrine/exocrine_gland_phen | 0.99579468 |
| 69 | MP0005253_abnormal_eye_physiology | 0.99275647 |
| 70 | MP0005410_abnormal_fertilization | 0.99193332 |
| 71 | MP0002722_abnormal_immune_system | 0.99021353 |
| 72 | MP0002088_abnormal_embryonic_growth/wei | 0.98077668 |
| 73 | MP0002102_abnormal_ear_morphology | 0.97123785 |
| 74 | MP0000689_abnormal_spleen_morphology | 0.96625397 |
| 75 | MP0002938_white_spotting | 0.94896871 |
| 76 | MP0001293_anophthalmia | 0.94659925 |
| 77 | MP0002277_abnormal_respiratory_mucosa | 0.94095412 |
| 78 | MP0000653_abnormal_sex_gland | 0.93297878 |
| 79 | MP0000372_irregular_coat_pigmentation | 0.92430326 |
| 80 | MP0003121_genomic_imprinting | 0.92090797 |
| 81 | MP0005332_abnormal_amino_acid | 0.90436814 |
| 82 | MP0001485_abnormal_pinna_reflex | 0.89989194 |
| 83 | MP0009785_altered_susceptibility_to | 0.88496016 |
| 84 | MP0002429_abnormal_blood_cell | 0.86298055 |
| 85 | MP0003787_abnormal_imprinting | 0.86229953 |
| 86 | MP0002090_abnormal_vision | 0.85705203 |
| 87 | MP0002085_abnormal_embryonic_tissue | 0.85191190 |
| 88 | MP0001986_abnormal_taste_sensitivity | 0.82109621 |
| 89 | MP0005645_abnormal_hypothalamus_physiol | 0.81923983 |
| 90 | MP0001873_stomach_inflammation | 0.81424616 |
| 91 | MP0000516_abnormal_urinary_system | 0.80750840 |
| 92 | MP0005367_renal/urinary_system_phenotyp | 0.80750840 |
| 93 | MP0005551_abnormal_eye_electrophysiolog | 0.79813067 |
| 94 | MP0005389_reproductive_system_phenotype | 0.79691578 |
| 95 | MP0003646_muscle_fatigue | 0.77945642 |
| 96 | MP0005174_abnormal_tail_pigmentation | 0.77707622 |
| 97 | MP0008872_abnormal_physiological_respon | 0.77687886 |
| 98 | MP0001905_abnormal_dopamine_level | 0.77636052 |
| 99 | MP0008789_abnormal_olfactory_epithelium | 0.76945836 |
| 100 | MP0010030_abnormal_orbit_morphology | 0.76619967 |
| 101 | MP0009765_abnormal_xenobiotic_induced | 0.76468570 |
| 102 | MP0008995_early_reproductive_senescence | 0.76176559 |
| 103 | MP0001984_abnormal_olfaction | 0.75955105 |
| 104 | MP0003221_abnormal_cardiomyocyte_apopto | 0.75111027 |
| 105 | MP0009764_decreased_sensitivity_to | 0.74673680 |
| 106 | MP0002751_abnormal_autonomic_nervous | 0.74599375 |
| 107 | MP0005266_abnormal_metabolism | 0.72837928 |
| 108 | MP0005387_immune_system_phenotype | 0.71778816 |
| 109 | MP0001790_abnormal_immune_system | 0.71778816 |
| 110 | MP0005671_abnormal_response_to | 0.70844906 |
| 111 | MP0010352_gastrointestinal_tract_polyps | 0.70762989 |
| 112 | MP0000015_abnormal_ear_pigmentation | 0.70641586 |
| 113 | MP0004215_abnormal_myocardial_fiber | 0.69492745 |
| 114 | MP0001119_abnormal_female_reproductive | 0.68866209 |
| 115 | MP0002084_abnormal_developmental_patter | 0.67016468 |
| 116 | MP0002086_abnormal_extraembryonic_tissu | 0.66745312 |
| 117 | MP0003941_abnormal_skin_development | 0.66266074 |
| 118 | MP0001881_abnormal_mammary_gland | 0.66250432 |
| 119 | MP0000716_abnormal_immune_system | 0.65563398 |
| 120 | MP0006072_abnormal_retinal_apoptosis | 0.64312423 |
| 121 | MP0002234_abnormal_pharynx_morphology | 0.63785466 |
| 122 | MP0000858_altered_metastatic_potential | 0.60369862 |
| 123 | MP0005084_abnormal_gallbladder_morpholo | 0.58260323 |
| 124 | MP0004197_abnormal_fetal_growth/weight/ | 0.58089862 |
| 125 | MP0001186_pigmentation_phenotype | 0.57972149 |
| 126 | MP0002638_abnormal_pupillary_reflex | 0.57910665 |
| 127 | MP0005384_cellular_phenotype | 0.57659095 |
| 128 | MP0005408_hypopigmentation | 0.52881370 |
| 129 | MP0008260_abnormal_autophagy | 0.51315348 |
| 130 | MP0005636_abnormal_mineral_homeostasis | 0.50902074 |
| 131 | MP0003698_abnormal_male_reproductive | 0.50514762 |
| 132 | MP0005409_darkened_coat_color | 0.50169349 |
| 133 | MP0004133_heterotaxia | 0.50054842 |
| 134 | MP0000613_abnormal_salivary_gland | 0.48402428 |
| 135 | MP0000465_gastrointestinal_hemorrhage | 0.45417295 |
| 136 | MP0010307_abnormal_tumor_latency | 0.44925988 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.89113468 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.85045855 |
| 3 | Reticulocytopenia (HP:0001896) | 4.82499649 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 4.45962989 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 4.34980609 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.12218366 |
| 7 | Aplastic anemia (HP:0001915) | 4.08042022 |
| 8 | Mitochondrial inheritance (HP:0001427) | 4.07400401 |
| 9 | Increased CSF lactate (HP:0002490) | 3.92101254 |
| 10 | Hepatocellular necrosis (HP:0001404) | 3.89240289 |
| 11 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.77900157 |
| 12 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.77900157 |
| 13 | Oral leukoplakia (HP:0002745) | 3.77263117 |
| 14 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 3.66358197 |
| 15 | Macrocytic anemia (HP:0001972) | 3.63108637 |
| 16 | Hepatic necrosis (HP:0002605) | 3.55087234 |
| 17 | Increased serum lactate (HP:0002151) | 3.54940299 |
| 18 | Acute encephalopathy (HP:0006846) | 3.46292562 |
| 19 | Pallor (HP:0000980) | 3.43132146 |
| 20 | Progressive macrocephaly (HP:0004481) | 3.35514948 |
| 21 | Increased hepatocellular lipid droplets (HP:0006565) | 3.35125056 |
| 22 | 3-Methylglutaconic aciduria (HP:0003535) | 3.22202247 |
| 23 | Type I transferrin isoform profile (HP:0003642) | 3.20923363 |
| 24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.10363703 |
| 25 | Lipid accumulation in hepatocytes (HP:0006561) | 3.09302654 |
| 26 | Microretrognathia (HP:0000308) | 3.09079722 |
| 27 | Breast hypoplasia (HP:0003187) | 3.00217965 |
| 28 | Microvesicular hepatic steatosis (HP:0001414) | 2.98007838 |
| 29 | Methylmalonic acidemia (HP:0002912) | 2.94188259 |
| 30 | Methylmalonic aciduria (HP:0012120) | 2.92416237 |
| 31 | Increased serum pyruvate (HP:0003542) | 2.91400567 |
| 32 | Abnormality of glycolysis (HP:0004366) | 2.91400567 |
| 33 | Lactic acidosis (HP:0003128) | 2.87661741 |
| 34 | Rough bone trabeculation (HP:0100670) | 2.87032589 |
| 35 | Cerebral hypomyelination (HP:0006808) | 2.84485320 |
| 36 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.80653561 |
| 37 | Carpal bone hypoplasia (HP:0001498) | 2.78351304 |
| 38 | Abnormality of the preputium (HP:0100587) | 2.73580032 |
| 39 | Exercise intolerance (HP:0003546) | 2.73097528 |
| 40 | Abnormality of the anterior horn cell (HP:0006802) | 2.66099065 |
| 41 | Degeneration of anterior horn cells (HP:0002398) | 2.66099065 |
| 42 | Abnormality of methionine metabolism (HP:0010901) | 2.65464053 |
| 43 | Pancytopenia (HP:0001876) | 2.63902206 |
| 44 | Premature graying of hair (HP:0002216) | 2.55753995 |
| 45 | Respiratory failure (HP:0002878) | 2.54708518 |
| 46 | Exertional dyspnea (HP:0002875) | 2.54618162 |
| 47 | Increased intramyocellular lipid droplets (HP:0012240) | 2.54171872 |
| 48 | Respiratory difficulties (HP:0002880) | 2.52505929 |
| 49 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.51201956 |
| 50 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.48449474 |
| 51 | Abnormality of alanine metabolism (HP:0010916) | 2.48449474 |
| 52 | Hyperalaninemia (HP:0003348) | 2.48449474 |
| 53 | 11 pairs of ribs (HP:0000878) | 2.48220759 |
| 54 | Patellar aplasia (HP:0006443) | 2.48202696 |
| 55 | Lethargy (HP:0001254) | 2.44716475 |
| 56 | Chromsome breakage (HP:0040012) | 2.44551439 |
| 57 | Type 2 muscle fiber atrophy (HP:0003554) | 2.43512898 |
| 58 | Selective tooth agenesis (HP:0001592) | 2.41586622 |
| 59 | Meckel diverticulum (HP:0002245) | 2.38818168 |
| 60 | Colon cancer (HP:0003003) | 2.38543365 |
| 61 | Patchy hypopigmentation of hair (HP:0011365) | 2.37653926 |
| 62 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.33635575 |
| 63 | Absent thumb (HP:0009777) | 2.33541966 |
| 64 | Abnormality of the ileum (HP:0001549) | 2.33231218 |
| 65 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.33090834 |
| 66 | Renal Fanconi syndrome (HP:0001994) | 2.32565494 |
| 67 | Myelodysplasia (HP:0002863) | 2.32515988 |
| 68 | Muscle fiber atrophy (HP:0100295) | 2.30095780 |
| 69 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.29623283 |
| 70 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.29623283 |
| 71 | Abnormal protein glycosylation (HP:0012346) | 2.29623283 |
| 72 | Abnormal glycosylation (HP:0012345) | 2.29623283 |
| 73 | Cerebral edema (HP:0002181) | 2.27888206 |
| 74 | Abnormality of chromosome stability (HP:0003220) | 2.27844338 |
| 75 | Increased IgM level (HP:0003496) | 2.23966465 |
| 76 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.21772012 |
| 77 | Reduced antithrombin III activity (HP:0001976) | 2.20568962 |
| 78 | Abnormal lung lobation (HP:0002101) | 2.20212561 |
| 79 | Bone marrow hypocellularity (HP:0005528) | 2.19052054 |
| 80 | Increased muscle lipid content (HP:0009058) | 2.16074915 |
| 81 | Abnormal spermatogenesis (HP:0008669) | 2.15030427 |
| 82 | Hyperglycinemia (HP:0002154) | 2.14323518 |
| 83 | Cellular immunodeficiency (HP:0005374) | 2.12716801 |
| 84 | Chronic otitis media (HP:0000389) | 2.12253334 |
| 85 | Thrombocytosis (HP:0001894) | 2.10829359 |
| 86 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.09682315 |
| 87 | Dicarboxylic aciduria (HP:0003215) | 2.09682315 |
| 88 | Abnormality of serum amino acid levels (HP:0003112) | 2.09539300 |
| 89 | Abnormality of the labia minora (HP:0012880) | 2.09226003 |
| 90 | Small intestinal stenosis (HP:0012848) | 2.06177707 |
| 91 | Duodenal stenosis (HP:0100867) | 2.06177707 |
| 92 | Abnormality of macular pigmentation (HP:0008002) | 2.05898295 |
| 93 | Sparse eyelashes (HP:0000653) | 2.05285157 |
| 94 | Severe visual impairment (HP:0001141) | 2.05118105 |
| 95 | Abnormality of renal resorption (HP:0011038) | 2.03818900 |
| 96 | Abnormality of urine glucose concentration (HP:0011016) | 2.03344716 |
| 97 | Glycosuria (HP:0003076) | 2.03344716 |
| 98 | Secondary amenorrhea (HP:0000869) | 2.01905181 |
| 99 | Abnormal number of incisors (HP:0011064) | 2.01100929 |
| 100 | Multiple enchondromatosis (HP:0005701) | 2.00185736 |
| 101 | Horseshoe kidney (HP:0000085) | 2.00065648 |
| 102 | Stomatitis (HP:0010280) | 1.98044747 |
| 103 | Abnormal trabecular bone morphology (HP:0100671) | 1.97054051 |
| 104 | Cutaneous melanoma (HP:0012056) | 1.96922410 |
| 105 | Cleft eyelid (HP:0000625) | 1.96401914 |
| 106 | Generalized aminoaciduria (HP:0002909) | 1.95519688 |
| 107 | CNS demyelination (HP:0007305) | 1.95416182 |
| 108 | Trismus (HP:0000211) | 1.94928541 |
| 109 | Abnormality of reticulocytes (HP:0004312) | 1.94699563 |
| 110 | Facial cleft (HP:0002006) | 1.94507385 |
| 111 | Emotional lability (HP:0000712) | 1.94277186 |
| 112 | IgM deficiency (HP:0002850) | 1.93781014 |
| 113 | Leukodystrophy (HP:0002415) | 1.92235394 |
| 114 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.91088281 |
| 115 | Triphalangeal thumb (HP:0001199) | 1.90848798 |
| 116 | Stenosis of the external auditory canal (HP:0000402) | 1.90093632 |
| 117 | Poor head control (HP:0002421) | 1.88553549 |
| 118 | Megaloblastic anemia (HP:0001889) | 1.88111373 |
| 119 | B lymphocytopenia (HP:0010976) | 1.88097935 |
| 120 | Unsteady gait (HP:0002317) | 1.87278530 |
| 121 | Optic disc pallor (HP:0000543) | 1.86292069 |
| 122 | Clubbing of toes (HP:0100760) | 1.85712300 |
| 123 | Irregular epiphyses (HP:0010582) | 1.85639807 |
| 124 | Neutropenia (HP:0001875) | 1.83762920 |
| 125 | Neoplasm of the adrenal gland (HP:0100631) | 1.80728064 |
| 126 | Median cleft lip (HP:0000161) | 1.78525316 |
| 127 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.78399045 |
| 128 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.77357630 |
| 129 | Nausea (HP:0002018) | 1.74785588 |
| 130 | IgG deficiency (HP:0004315) | 1.73727436 |
| 131 | Chronic sinusitis (HP:0011109) | 1.73576414 |
| 132 | Abnormality of midbrain morphology (HP:0002418) | 1.73447844 |
| 133 | Molar tooth sign on MRI (HP:0002419) | 1.73447844 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.76234602 |
| 2 | STK16 | 4.41083642 |
| 3 | WEE1 | 4.28273288 |
| 4 | EIF2AK1 | 3.59667562 |
| 5 | VRK2 | 3.40570314 |
| 6 | NME2 | 3.26790438 |
| 7 | CDC7 | 3.05968722 |
| 8 | EIF2AK3 | 2.63589577 |
| 9 | VRK1 | 2.63068065 |
| 10 | SRPK1 | 2.50505112 |
| 11 | TRIM28 | 2.37012588 |
| 12 | BRSK2 | 2.31843366 |
| 13 | TSSK6 | 2.28933671 |
| 14 | ACVR1B | 2.14401317 |
| 15 | NME1 | 2.14286989 |
| 16 | NUAK1 | 2.09688837 |
| 17 | PLK4 | 1.98320896 |
| 18 | MKNK1 | 1.85341712 |
| 19 | CCNB1 | 1.77149648 |
| 20 | DYRK3 | 1.77114969 |
| 21 | NEK1 | 1.67735308 |
| 22 | PLK1 | 1.65731841 |
| 23 | TLK1 | 1.62484469 |
| 24 | NEK2 | 1.58484107 |
| 25 | TESK2 | 1.57100072 |
| 26 | MAP4K2 | 1.54545544 |
| 27 | PASK | 1.42425877 |
| 28 | AURKB | 1.42409627 |
| 29 | TTK | 1.39987539 |
| 30 | BRSK1 | 1.39959052 |
| 31 | PIM2 | 1.38127790 |
| 32 | MKNK2 | 1.33465509 |
| 33 | PLK3 | 1.32429651 |
| 34 | ATR | 1.31599111 |
| 35 | CDK8 | 1.31147753 |
| 36 | PDK2 | 1.28994774 |
| 37 | FRK | 1.23083257 |
| 38 | CDK7 | 1.23045500 |
| 39 | ZAK | 1.20672718 |
| 40 | AURKA | 1.18252545 |
| 41 | GRK7 | 1.17979625 |
| 42 | WNK3 | 1.11639358 |
| 43 | TAF1 | 1.09623118 |
| 44 | RPS6KB2 | 1.09315139 |
| 45 | TGFBR1 | 1.06932258 |
| 46 | KDR | 1.03903662 |
| 47 | BCKDK | 0.99762729 |
| 48 | TGFBR2 | 0.99582563 |
| 49 | PBK | 0.97708010 |
| 50 | SCYL2 | 0.97522842 |
| 51 | FLT3 | 0.96222673 |
| 52 | EIF2AK2 | 0.90569449 |
| 53 | RPS6KA4 | 0.89509405 |
| 54 | CHEK2 | 0.88288178 |
| 55 | CDK19 | 0.86332248 |
| 56 | GRK1 | 0.85654309 |
| 57 | CSNK2A1 | 0.84834052 |
| 58 | TAOK2 | 0.83302964 |
| 59 | BRAF | 0.82863055 |
| 60 | TEC | 0.80177512 |
| 61 | CSNK1G1 | 0.78997366 |
| 62 | CLK1 | 0.78752594 |
| 63 | CSNK2A2 | 0.76490045 |
| 64 | BCR | 0.74654874 |
| 65 | CHEK1 | 0.72943107 |
| 66 | OXSR1 | 0.72796024 |
| 67 | GRK5 | 0.72085140 |
| 68 | STK39 | 0.71220963 |
| 69 | MAP3K8 | 0.70520246 |
| 70 | INSRR | 0.69368059 |
| 71 | RPS6KA5 | 0.65280398 |
| 72 | CSNK1G2 | 0.62708008 |
| 73 | CDK4 | 0.62457484 |
| 74 | MAP4K1 | 0.60136264 |
| 75 | TESK1 | 0.58739349 |
| 76 | MST4 | 0.57499113 |
| 77 | EPHA2 | 0.55572180 |
| 78 | MOS | 0.54195618 |
| 79 | STK24 | 0.54044257 |
| 80 | STK4 | 0.53956897 |
| 81 | ERBB3 | 0.53773645 |
| 82 | ATM | 0.53700122 |
| 83 | MAP3K11 | 0.53315899 |
| 84 | CSNK1A1L | 0.51991538 |
| 85 | ZAP70 | 0.49463258 |
| 86 | PDK3 | 0.48842475 |
| 87 | PDK4 | 0.48842475 |
| 88 | TNIK | 0.48378236 |
| 89 | DYRK2 | 0.47398339 |
| 90 | CDK3 | 0.47262641 |
| 91 | PLK2 | 0.46014157 |
| 92 | TXK | 0.46006560 |
| 93 | ADRBK2 | 0.45214538 |
| 94 | CDK2 | 0.44845590 |
| 95 | PAK1 | 0.44468551 |
| 96 | MAP3K12 | 0.44297998 |
| 97 | MYLK | 0.43573097 |
| 98 | STK10 | 0.43442873 |
| 99 | MARK3 | 0.42945923 |
| 100 | KIT | 0.42765137 |
| 101 | MUSK | 0.42629471 |
| 102 | DAPK3 | 0.41641701 |
| 103 | STK3 | 0.41210797 |
| 104 | PIM1 | 0.41161983 |
| 105 | BMPR2 | 0.41156536 |
| 106 | MAP2K3 | 0.40622109 |
| 107 | MAP2K6 | 0.38912830 |
| 108 | CDK1 | 0.38731199 |
| 109 | PAK4 | 0.38299864 |
| 110 | STK38L | 0.38174326 |
| 111 | LRRK2 | 0.37328641 |
| 112 | NLK | 0.37263138 |
| 113 | LIMK1 | 0.36224310 |
| 114 | BTK | 0.35640000 |
| 115 | PRKCI | 0.34387496 |
| 116 | ILK | 0.34343846 |
| 117 | IRAK4 | 0.34254492 |
| 118 | IKBKB | 0.33247510 |
| 119 | SIK3 | 0.32818398 |
| 120 | ADRBK1 | 0.31827308 |
| 121 | MAP3K4 | 0.30732768 |
| 122 | OBSCN | 0.30537447 |
| 123 | CSNK1G3 | 0.30324086 |
| 124 | MAP3K3 | 0.30267574 |
| 125 | ABL2 | 0.29045663 |
| 126 | BMPR1B | 0.28838302 |
| 127 | DAPK1 | 0.28282063 |
| 128 | LYN | 0.26743354 |
| 129 | MAPKAPK3 | 0.25693091 |
| 130 | MAP3K5 | 0.24956140 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.59739721 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.52725493 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 4.51341265 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.92156706 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.72390599 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.24339661 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.06848517 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.92425160 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.82452348 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.78556956 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.73352101 |
| 12 | RNA transport_Homo sapiens_hsa03013 | 2.51226553 |
| 13 | Protein export_Homo sapiens_hsa03060 | 2.24270825 |
| 14 | Parkinsons disease_Homo sapiens_hsa05012 | 2.22049388 |
| 15 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.20407632 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.13973906 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.00564854 |
| 18 | Cell cycle_Homo sapiens_hsa04110 | 1.96821164 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.95285067 |
| 20 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.89134590 |
| 21 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.87842082 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.86266829 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.76926873 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.68086204 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.39032200 |
| 26 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.38940341 |
| 27 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.34488754 |
| 28 | Alzheimers disease_Homo sapiens_hsa05010 | 1.28133123 |
| 29 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.26799506 |
| 30 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.21109286 |
| 31 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.15281738 |
| 32 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.14370773 |
| 33 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.12233269 |
| 34 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.06847087 |
| 35 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.01831398 |
| 36 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.00408984 |
| 37 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.00303472 |
| 38 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.93750649 |
| 39 | Sulfur relay system_Homo sapiens_hsa04122 | 0.91175807 |
| 40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.90195545 |
| 41 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.89546821 |
| 42 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.85933920 |
| 43 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.85675501 |
| 44 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.85360676 |
| 45 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.85136170 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.76672184 |
| 47 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.69833493 |
| 48 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.68066356 |
| 49 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.64406851 |
| 50 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.63750515 |
| 51 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.62946155 |
| 52 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.60176892 |
| 53 | Metabolic pathways_Homo sapiens_hsa01100 | 0.59951974 |
| 54 | Carbon metabolism_Homo sapiens_hsa01200 | 0.59900145 |
| 55 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.58790303 |
| 56 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.56434493 |
| 57 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.53716540 |
| 58 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.52669539 |
| 59 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.51967364 |
| 60 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.51562440 |
| 61 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.50260580 |
| 62 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.48339745 |
| 63 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.47583634 |
| 64 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.46312262 |
| 65 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.45354155 |
| 66 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.45222555 |
| 67 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.45056565 |
| 68 | Retinol metabolism_Homo sapiens_hsa00830 | 0.43746725 |
| 69 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.42276362 |
| 70 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.41930925 |
| 71 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.40851412 |
| 72 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.40057738 |
| 73 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.39514393 |
| 74 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.38960500 |
| 75 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.38427301 |
| 76 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.38375730 |
| 77 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.37826950 |
| 78 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.37156008 |
| 79 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.36937654 |
| 80 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.36146698 |
| 81 | Galactose metabolism_Homo sapiens_hsa00052 | 0.36026303 |
| 82 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.35125721 |
| 83 | Legionellosis_Homo sapiens_hsa05134 | 0.34337088 |
| 84 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.34241386 |
| 85 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.33910938 |
| 86 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.33864718 |
| 87 | HTLV-I infection_Homo sapiens_hsa05166 | 0.28947052 |
| 88 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.28800390 |
| 89 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.28798940 |
| 90 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.27698114 |
| 91 | Phototransduction_Homo sapiens_hsa04744 | 0.27470781 |
| 92 | Alcoholism_Homo sapiens_hsa05034 | 0.27166768 |
| 93 | Thyroid cancer_Homo sapiens_hsa05216 | 0.25851550 |
| 94 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.25781558 |
| 95 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.24698849 |
| 96 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.24615941 |
| 97 | Mineral absorption_Homo sapiens_hsa04978 | 0.24377120 |
| 98 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.24152226 |
| 99 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.23670392 |
| 100 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.23638736 |
| 101 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.23256055 |
| 102 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.20985799 |
| 103 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.17519172 |
| 104 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.13841987 |
| 105 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.13594886 |
| 106 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.08092277 |
| 107 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.05704068 |
| 108 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.04352029 |
| 109 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.04303970 |
| 110 | Asthma_Homo sapiens_hsa05310 | 0.02706533 |
| 111 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.02209239 |
| 112 | Shigellosis_Homo sapiens_hsa05131 | 0.01804549 |
| 113 | Allograft rejection_Homo sapiens_hsa05330 | 0.01551413 |
| 114 | Measles_Homo sapiens_hsa05162 | 0.01454142 |
| 115 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.01157041 |
| 116 | Peroxisome_Homo sapiens_hsa04146 | 0.00830107 |
| 117 | Apoptosis_Homo sapiens_hsa04210 | 0.00766867 |
| 118 | Hepatitis B_Homo sapiens_hsa05161 | -0.0320781 |
| 119 | Chemical carcinogenesis_Homo sapiens_hsa05204 | -0.0298759 |
| 120 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | -0.0216173 |
| 121 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | -0.0192156 |
| 122 | Propanoate metabolism_Homo sapiens_hsa00640 | -0.0115020 |
| 123 | Phenylalanine metabolism_Homo sapiens_hsa00360 | -0.0094811 |
| 124 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | -0.0009866 |

