

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.60561071 |
| 2 | viral transcription (GO:0019083) | 5.54180464 |
| 3 | ribosomal small subunit biogenesis (GO:0042274) | 5.53707624 |
| 4 | translational termination (GO:0006415) | 5.39639769 |
| 5 | maturation of SSU-rRNA (GO:0030490) | 5.27448992 |
| 6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.07951287 |
| 7 | DNA deamination (GO:0045006) | 5.00759232 |
| 8 | proteasome assembly (GO:0043248) | 4.98122145 |
| 9 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.96591370 |
| 10 | ribosomal large subunit biogenesis (GO:0042273) | 4.93362770 |
| 11 | cotranslational protein targeting to membrane (GO:0006613) | 4.92932727 |
| 12 | protein targeting to ER (GO:0045047) | 4.87058747 |
| 13 | translational elongation (GO:0006414) | 4.75289673 |
| 14 | ATP synthesis coupled proton transport (GO:0015986) | 4.73765977 |
| 15 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.73765977 |
| 16 | chaperone-mediated protein transport (GO:0072321) | 4.69481088 |
| 17 | protein localization to endoplasmic reticulum (GO:0070972) | 4.67259223 |
| 18 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.60902999 |
| 19 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.58887137 |
| 20 | respiratory chain complex IV assembly (GO:0008535) | 4.48188317 |
| 21 | translational initiation (GO:0006413) | 4.44415052 |
| 22 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.42050432 |
| 23 | cellular protein complex disassembly (GO:0043624) | 4.28546111 |
| 24 | cytochrome complex assembly (GO:0017004) | 4.27009655 |
| 25 | viral life cycle (GO:0019058) | 4.24608656 |
| 26 | formation of translation preinitiation complex (GO:0001731) | 4.22960673 |
| 27 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.22205192 |
| 28 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.20385940 |
| 29 | translation (GO:0006412) | 4.20066148 |
| 30 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.13841553 |
| 31 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.13027823 |
| 32 | termination of RNA polymerase III transcription (GO:0006386) | 4.13027823 |
| 33 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.11061836 |
| 34 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.10083394 |
| 35 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.09253592 |
| 36 | negative regulation of ligase activity (GO:0051352) | 4.08438050 |
| 37 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.08438050 |
| 38 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.01746413 |
| 39 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.99759359 |
| 40 | establishment of integrated proviral latency (GO:0075713) | 3.99505874 |
| 41 | DNA strand elongation (GO:0022616) | 3.99257028 |
| 42 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.97493576 |
| 43 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.95834855 |
| 44 | rRNA modification (GO:0000154) | 3.92076017 |
| 45 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.90996477 |
| 46 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.89133132 |
| 47 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.89133132 |
| 48 | nucleobase biosynthetic process (GO:0046112) | 3.87132320 |
| 49 | rRNA processing (GO:0006364) | 3.86806590 |
| 50 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.85972765 |
| 51 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.85972765 |
| 52 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.85972765 |
| 53 | purine nucleobase biosynthetic process (GO:0009113) | 3.85016764 |
| 54 | 7-methylguanosine mRNA capping (GO:0006370) | 3.84470467 |
| 55 | spliceosomal snRNP assembly (GO:0000387) | 3.82226479 |
| 56 | peptidyl-histidine modification (GO:0018202) | 3.79154280 |
| 57 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.77886162 |
| 58 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.77886162 |
| 59 | RNA capping (GO:0036260) | 3.77574678 |
| 60 | 7-methylguanosine RNA capping (GO:0009452) | 3.77574678 |
| 61 | pseudouridine synthesis (GO:0001522) | 3.76991628 |
| 62 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.75899084 |
| 63 | protein targeting to mitochondrion (GO:0006626) | 3.72220466 |
| 64 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.71949040 |
| 65 | cellular component biogenesis (GO:0044085) | 3.71666053 |
| 66 | protein complex disassembly (GO:0043241) | 3.70339692 |
| 67 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.70172706 |
| 68 | rRNA metabolic process (GO:0016072) | 3.69266784 |
| 69 | protein deneddylation (GO:0000338) | 3.64741439 |
| 70 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.64722565 |
| 71 | telomere maintenance via recombination (GO:0000722) | 3.64319530 |
| 72 | GTP biosynthetic process (GO:0006183) | 3.63092647 |
| 73 | DNA replication initiation (GO:0006270) | 3.62160908 |
| 74 | establishment of protein localization to mitochondrion (GO:0072655) | 3.61981612 |
| 75 | macromolecular complex disassembly (GO:0032984) | 3.55983866 |
| 76 | maturation of 5.8S rRNA (GO:0000460) | 3.53737292 |
| 77 | regulation of mitochondrial translation (GO:0070129) | 3.53072613 |
| 78 | mannosylation (GO:0097502) | 3.50566543 |
| 79 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.49010274 |
| 80 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.48963517 |
| 81 | NADH dehydrogenase complex assembly (GO:0010257) | 3.47305067 |
| 82 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.47305067 |
| 83 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.47305067 |
| 84 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.46974268 |
| 85 | respiratory electron transport chain (GO:0022904) | 3.45161028 |
| 86 | DNA replication checkpoint (GO:0000076) | 3.42684258 |
| 87 | protein neddylation (GO:0045116) | 3.41797806 |
| 88 | UTP biosynthetic process (GO:0006228) | 3.41515490 |
| 89 | positive regulation of ligase activity (GO:0051351) | 3.39368449 |
| 90 | establishment of viral latency (GO:0019043) | 3.38658534 |
| 91 | electron transport chain (GO:0022900) | 3.37743679 |
| 92 | replication fork processing (GO:0031297) | 3.36821693 |
| 93 | CENP-A containing nucleosome assembly (GO:0034080) | 3.36010494 |
| 94 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.34865107 |
| 95 | ribosome biogenesis (GO:0042254) | 3.34784154 |
| 96 | protein localization to mitochondrion (GO:0070585) | 3.34009113 |
| 97 | transcription from mitochondrial promoter (GO:0006390) | 3.33459961 |
| 98 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.33134345 |
| 99 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.32514936 |
| 100 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.32514936 |
| 101 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.30042510 |
| 102 | protein K6-linked ubiquitination (GO:0085020) | 3.28019735 |
| 103 | mitotic recombination (GO:0006312) | 3.25936554 |
| 104 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.25413647 |
| 105 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.25413647 |
| 106 | protein complex biogenesis (GO:0070271) | 3.24450032 |
| 107 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.23913841 |
| 108 | mitochondrial RNA metabolic process (GO:0000959) | 3.23347523 |
| 109 | chromatin remodeling at centromere (GO:0031055) | 3.22698890 |
| 110 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.22077900 |
| 111 | cullin deneddylation (GO:0010388) | 3.21090248 |
| 112 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.20259218 |
| 113 | platelet dense granule organization (GO:0060155) | 3.07577223 |
| 114 | metallo-sulfur cluster assembly (GO:0031163) | 3.05072768 |
| 115 | iron-sulfur cluster assembly (GO:0016226) | 3.05072768 |
| 116 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.04929058 |
| 117 | tRNA processing (GO:0008033) | 3.03474705 |
| 118 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.00159747 |
| 119 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.00029493 |
| 120 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.97213156 |
| 121 | inner mitochondrial membrane organization (GO:0007007) | 2.97038500 |
| 122 | oxidative phosphorylation (GO:0006119) | 2.96531989 |
| 123 | rRNA methylation (GO:0031167) | 2.96202356 |
| 124 | DNA damage response, detection of DNA damage (GO:0042769) | 2.93182165 |
| 125 | CTP metabolic process (GO:0046036) | 2.92238825 |
| 126 | CTP biosynthetic process (GO:0006241) | 2.92238825 |
| 127 | intracellular protein transmembrane import (GO:0044743) | 2.91807250 |
| 128 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.89000747 |
| 129 | UTP metabolic process (GO:0046051) | 2.88184084 |
| 130 | mitochondrial transport (GO:0006839) | 2.87105414 |
| 131 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.84878203 |
| 132 | base-excision repair, AP site formation (GO:0006285) | 2.81215483 |
| 133 | protein-cofactor linkage (GO:0018065) | 2.79882913 |
| 134 | tRNA metabolic process (GO:0006399) | 2.79520324 |
| 135 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.78142622 |
| 136 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.77461590 |
| 137 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.75700039 |
| 138 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.71646649 |
| 139 | regulation of ligase activity (GO:0051340) | 2.68958165 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.27582882 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.67280051 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.45077765 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.28390310 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.20349368 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.12842568 |
| 7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.06199078 |
| 8 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.99533606 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.74384497 |
| 10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.62719460 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.46145385 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.29758587 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.22587893 |
| 14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.14003040 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.93386036 |
| 16 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.89734854 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.87508624 |
| 18 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.85979361 |
| 19 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.84553124 |
| 20 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.81437674 |
| 21 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.76694644 |
| 22 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.70149044 |
| 23 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.64136528 |
| 24 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.54482583 |
| 25 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.46997397 |
| 26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.44545303 |
| 27 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.33966645 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.27724175 |
| 29 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.26004179 |
| 30 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.23612397 |
| 31 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.21451112 |
| 32 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.21226243 |
| 33 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.14026254 |
| 34 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.07103792 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.04326368 |
| 36 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.00491774 |
| 37 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.93353886 |
| 38 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.88389529 |
| 39 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.81774671 |
| 40 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.73316604 |
| 41 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.72748985 |
| 42 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.68194483 |
| 43 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67772545 |
| 44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.65532377 |
| 45 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.64954476 |
| 46 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.63341820 |
| 47 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.61454364 |
| 48 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.56091924 |
| 49 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.54747298 |
| 50 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.51024277 |
| 51 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.47825759 |
| 52 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.45375799 |
| 53 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.45336480 |
| 54 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.43549413 |
| 55 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.43194851 |
| 56 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.41410473 |
| 57 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.31909997 |
| 58 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.29280761 |
| 59 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25809395 |
| 60 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.25671776 |
| 61 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.24208410 |
| 62 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.22390850 |
| 63 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.21108467 |
| 64 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.20366165 |
| 65 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.14924914 |
| 66 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.14910485 |
| 67 | VDR_22108803_ChIP-Seq_LS180_Human | 1.14478455 |
| 68 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.13738335 |
| 69 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.13652503 |
| 70 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.11129015 |
| 71 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.09077659 |
| 72 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.08835123 |
| 73 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.08831723 |
| 74 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07404131 |
| 75 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.05944414 |
| 76 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.04398243 |
| 77 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.02405167 |
| 78 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99495824 |
| 79 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.98725960 |
| 80 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.97150353 |
| 81 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.96971672 |
| 82 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.96645141 |
| 83 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.92577495 |
| 84 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.90927119 |
| 85 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.89655179 |
| 86 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.89541670 |
| 87 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.89400409 |
| 88 | EWS_26573619_Chip-Seq_HEK293_Human | 0.89195847 |
| 89 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.88451444 |
| 90 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.87834359 |
| 91 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.87828455 |
| 92 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.84578495 |
| 93 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.84552279 |
| 94 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84406253 |
| 95 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.84151428 |
| 96 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.80203798 |
| 97 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.78932184 |
| 98 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.77842320 |
| 99 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.77264672 |
| 100 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.76338292 |
| 101 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.76338292 |
| 102 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.74362883 |
| 103 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.74061594 |
| 104 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.74049677 |
| 105 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.72757723 |
| 106 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.72408388 |
| 107 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.71788306 |
| 108 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.71228216 |
| 109 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.70987320 |
| 110 | AR_20517297_ChIP-Seq_VCAP_Human | 0.70799576 |
| 111 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.69783768 |
| 112 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.68792927 |
| 113 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.68673754 |
| 114 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.66902016 |
| 115 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.66808335 |
| 116 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.66765306 |
| 117 | NCOR_22424771_ChIP-Seq_293T_Human | 0.66742220 |
| 118 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.66311826 |
| 119 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.66037612 |
| 120 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.64630499 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.12301815 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.29032166 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.81049164 |
| 4 | MP0003806_abnormal_nucleotide_metabolis | 3.80371927 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.54620810 |
| 6 | MP0008058_abnormal_DNA_repair | 3.36376084 |
| 7 | MP0009379_abnormal_foot_pigmentation | 3.35414324 |
| 8 | MP0003077_abnormal_cell_cycle | 3.24280681 |
| 9 | MP0008057_abnormal_DNA_replication | 2.95166861 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.78468207 |
| 11 | MP0001529_abnormal_vocalization | 2.68936638 |
| 12 | MP0003718_maternal_effect | 2.66771999 |
| 13 | MP0002837_dystrophic_cardiac_calcinosis | 2.39636984 |
| 14 | MP0006036_abnormal_mitochondrial_physio | 2.30917614 |
| 15 | MP0002396_abnormal_hematopoietic_system | 2.26241218 |
| 16 | MP0003186_abnormal_redox_activity | 2.22590508 |
| 17 | MP0008007_abnormal_cellular_replicative | 2.13785363 |
| 18 | MP0004147_increased_porphyrin_level | 2.11948135 |
| 19 | MP0001905_abnormal_dopamine_level | 2.07134305 |
| 20 | MP0009333_abnormal_splenocyte_physiolog | 2.06908190 |
| 21 | MP0006035_abnormal_mitochondrial_morpho | 2.06520506 |
| 22 | MP0006292_abnormal_olfactory_placode | 2.04960749 |
| 23 | MP0003786_premature_aging | 2.04613483 |
| 24 | MP0006072_abnormal_retinal_apoptosis | 2.02983666 |
| 25 | MP0003195_calcinosis | 2.02143211 |
| 26 | MP0008995_early_reproductive_senescence | 1.95289099 |
| 27 | MP0002876_abnormal_thyroid_physiology | 1.89882809 |
| 28 | MP0008875_abnormal_xenobiotic_pharmacok | 1.83709209 |
| 29 | MP0003656_abnormal_erythrocyte_physiolo | 1.79699283 |
| 30 | MP0005551_abnormal_eye_electrophysiolog | 1.69718219 |
| 31 | MP0001764_abnormal_homeostasis | 1.62542895 |
| 32 | MP0005646_abnormal_pituitary_gland | 1.59278449 |
| 33 | MP0001730_embryonic_growth_arrest | 1.57560299 |
| 34 | MP0005408_hypopigmentation | 1.57050710 |
| 35 | MP0005084_abnormal_gallbladder_morpholo | 1.56977277 |
| 36 | MP0001968_abnormal_touch/_nociception | 1.54917093 |
| 37 | MP0002132_abnormal_respiratory_system | 1.52068397 |
| 38 | MP0008260_abnormal_autophagy | 1.51590789 |
| 39 | MP0000490_abnormal_crypts_of | 1.51418871 |
| 40 | MP0005075_abnormal_melanosome_morpholog | 1.48690583 |
| 41 | MP0003123_paternal_imprinting | 1.46277751 |
| 42 | MP0002638_abnormal_pupillary_reflex | 1.44173419 |
| 43 | MP0009046_muscle_twitch | 1.41688581 |
| 44 | MP0005645_abnormal_hypothalamus_physiol | 1.39085105 |
| 45 | MP0009697_abnormal_copulation | 1.36992712 |
| 46 | MP0005332_abnormal_amino_acid | 1.35484408 |
| 47 | MP0003315_abnormal_perineum_morphology | 1.31903841 |
| 48 | MP0000350_abnormal_cell_proliferation | 1.30560259 |
| 49 | MP0002938_white_spotting | 1.26653427 |
| 50 | MP0000358_abnormal_cell_content/ | 1.26474916 |
| 51 | MP0003136_yellow_coat_color | 1.21948630 |
| 52 | MP0001853_heart_inflammation | 1.20579418 |
| 53 | MP0001929_abnormal_gametogenesis | 1.19606512 |
| 54 | MP0000313_abnormal_cell_death | 1.17961629 |
| 55 | MP0005253_abnormal_eye_physiology | 1.17960833 |
| 56 | MP0004142_abnormal_muscle_tone | 1.16972242 |
| 57 | MP0002254_reproductive_system_inflammat | 1.16618708 |
| 58 | MP0001727_abnormal_embryo_implantation | 1.16335708 |
| 59 | MP0003763_abnormal_thymus_physiology | 1.15956151 |
| 60 | MP0002019_abnormal_tumor_incidence | 1.13946061 |
| 61 | MP0005451_abnormal_body_composition | 1.13940529 |
| 62 | MP0002163_abnormal_gland_morphology | 1.12874173 |
| 63 | MP0001919_abnormal_reproductive_system | 1.11228230 |
| 64 | MP0005671_abnormal_response_to | 1.10818046 |
| 65 | MP0002102_abnormal_ear_morphology | 1.10004211 |
| 66 | MP0005367_renal/urinary_system_phenotyp | 1.09769012 |
| 67 | MP0000516_abnormal_urinary_system | 1.09769012 |
| 68 | MP0006276_abnormal_autonomic_nervous | 1.07970712 |
| 69 | MP0002160_abnormal_reproductive_system | 1.05090612 |
| 70 | MP0000372_irregular_coat_pigmentation | 1.03804904 |
| 71 | MP0001545_abnormal_hematopoietic_system | 1.03048777 |
| 72 | MP0005397_hematopoietic_system_phenotyp | 1.03048777 |
| 73 | MP0001661_extended_life_span | 1.02301206 |
| 74 | MP0002398_abnormal_bone_marrow | 1.01627321 |
| 75 | MP0000689_abnormal_spleen_morphology | 1.01232047 |
| 76 | MP0005410_abnormal_fertilization | 1.01121714 |
| 77 | MP0008877_abnormal_DNA_methylation | 1.01114099 |
| 78 | MP0002722_abnormal_immune_system | 1.00773848 |
| 79 | MP0000653_abnormal_sex_gland | 1.00615613 |
| 80 | MP0002080_prenatal_lethality | 1.00214653 |
| 81 | MP0003880_abnormal_central_pattern | 0.98470291 |
| 82 | MP0001986_abnormal_taste_sensitivity | 0.95357338 |
| 83 | MP0001944_abnormal_pancreas_morphology | 0.95168244 |
| 84 | MP0005083_abnormal_biliary_tract | 0.93602302 |
| 85 | MP0009785_altered_susceptibility_to | 0.92890947 |
| 86 | MP0005636_abnormal_mineral_homeostasis | 0.92550697 |
| 87 | MP0002234_abnormal_pharynx_morphology | 0.91788937 |
| 88 | MP0002429_abnormal_blood_cell | 0.91537970 |
| 89 | MP0000647_abnormal_sebaceous_gland | 0.91090337 |
| 90 | MP0005220_abnormal_exocrine_pancreas | 0.89891522 |
| 91 | MP0000427_abnormal_hair_cycle | 0.89413786 |
| 92 | MP0005409_darkened_coat_color | 0.88386341 |
| 93 | MP0000631_abnormal_neuroendocrine_gland | 0.88323687 |
| 94 | MP0000703_abnormal_thymus_morphology | 0.87103394 |
| 95 | MP0001542_abnormal_bone_strength | 0.87064483 |
| 96 | MP0003698_abnormal_male_reproductive | 0.87034502 |
| 97 | MP0001697_abnormal_embryo_size | 0.85983185 |
| 98 | MP0002090_abnormal_vision | 0.85778913 |
| 99 | MP0002095_abnormal_skin_pigmentation | 0.84801763 |
| 100 | MP0009745_abnormal_behavioral_response | 0.83482147 |
| 101 | MP0003011_delayed_dark_adaptation | 0.82791272 |
| 102 | MP0005174_abnormal_tail_pigmentation | 0.81660519 |
| 103 | MP0002693_abnormal_pancreas_physiology | 0.81054221 |
| 104 | MP0001188_hyperpigmentation | 0.80959314 |
| 105 | MP0004133_heterotaxia | 0.80635783 |
| 106 | MP0000465_gastrointestinal_hemorrhage | 0.79725875 |
| 107 | MP0006054_spinal_hemorrhage | 0.78167796 |
| 108 | MP0000015_abnormal_ear_pigmentation | 0.77829659 |
| 109 | MP0001756_abnormal_urination | 0.77435592 |
| 110 | MP0002277_abnormal_respiratory_mucosa | 0.77215448 |
| 111 | MP0005266_abnormal_metabolism | 0.75621787 |
| 112 | MP0005379_endocrine/exocrine_gland_phen | 0.75072344 |
| 113 | MP0005376_homeostasis/metabolism_phenot | 0.74919773 |
| 114 | MP0000716_abnormal_immune_system | 0.74809164 |
| 115 | MP0005670_abnormal_white_adipose | 0.74186310 |
| 116 | MP0004381_abnormal_hair_follicle | 0.73707645 |
| 117 | MP0003567_abnormal_fetal_cardiomyocyte | 0.73331975 |
| 118 | MP0005395_other_phenotype | 0.73157463 |
| 119 | MP0002751_abnormal_autonomic_nervous | 0.72901796 |
| 120 | MP0001984_abnormal_olfaction | 0.72674977 |
| 121 | MP0001324_abnormal_eye_pigmentation | 0.72600699 |
| 122 | MP0001835_abnormal_antigen_presentation | 0.72533769 |
| 123 | MP0001119_abnormal_female_reproductive | 0.72181518 |
| 124 | MP0003221_abnormal_cardiomyocyte_apopto | 0.71583376 |
| 125 | MP0003137_abnormal_impulse_conducting | 0.70426960 |
| 126 | MP0005389_reproductive_system_phenotype | 0.70161004 |
| 127 | MP0002148_abnormal_hypersensitivity_rea | 0.69286916 |
| 128 | MP0002210_abnormal_sex_determination | 0.68256751 |
| 129 | MP0004019_abnormal_vitamin_homeostasis | 0.67936478 |
| 130 | MP0004043_abnormal_pH_regulation | 0.67053781 |
| 131 | MP0001145_abnormal_male_reproductive | 0.66713705 |
| 132 | MP0000858_altered_metastatic_potential | 0.65879078 |
| 133 | MP0005171_absent_coat_pigmentation | 0.65592047 |
| 134 | MP0005380_embryogenesis_phenotype | 0.65579204 |
| 135 | MP0001672_abnormal_embryogenesis/_devel | 0.65579204 |
| 136 | MP0002909_abnormal_adrenal_gland | 0.65320271 |
| 137 | MP0005025_abnormal_response_to | 0.63460694 |
| 138 | MP0008872_abnormal_physiological_respon | 0.63225189 |
| 139 | MP0002420_abnormal_adaptive_immunity | 0.62870295 |
| 140 | MP0003787_abnormal_imprinting | 0.62770346 |
| 141 | MP0000371_diluted_coat_color | 0.62742187 |
| 142 | MP0008873_increased_physiological_sensi | 0.61964575 |
| 143 | MP0001346_abnormal_lacrimal_gland | 0.61578862 |
| 144 | MP0002723_abnormal_immune_serum | 0.60479252 |
| 145 | MP0001819_abnormal_immune_cell | 0.59971822 |
| 146 | MP0001485_abnormal_pinna_reflex | 0.59633370 |
| 147 | MP0001800_abnormal_humoral_immune | 0.58795664 |
| 148 | MP0008789_abnormal_olfactory_epithelium | 0.58240672 |
| 149 | MP0002736_abnormal_nociception_after | 0.57363924 |
| 150 | MP0008469_abnormal_protein_level | 0.55847518 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.81418094 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.57284711 |
| 3 | Acute necrotizing encephalopathy (HP:0006965) | 5.18625129 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.83874303 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.73960866 |
| 6 | Reticulocytopenia (HP:0001896) | 4.54251142 |
| 7 | Hepatocellular necrosis (HP:0001404) | 4.53942210 |
| 8 | Increased CSF lactate (HP:0002490) | 4.39341421 |
| 9 | Acute encephalopathy (HP:0006846) | 4.36923171 |
| 10 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.27302801 |
| 11 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.27302801 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 4.22489610 |
| 13 | 3-Methylglutaconic aciduria (HP:0003535) | 4.13936539 |
| 14 | Progressive macrocephaly (HP:0004481) | 4.12898490 |
| 15 | Hepatic necrosis (HP:0002605) | 4.08500136 |
| 16 | Macrocytic anemia (HP:0001972) | 4.05642761 |
| 17 | Birth length less than 3rd percentile (HP:0003561) | 4.05569365 |
| 18 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.04988990 |
| 19 | Increased serum pyruvate (HP:0003542) | 3.98725924 |
| 20 | Abnormality of glycolysis (HP:0004366) | 3.98725924 |
| 21 | Cerebral hypomyelination (HP:0006808) | 3.85643029 |
| 22 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.77544600 |
| 23 | Lipid accumulation in hepatocytes (HP:0006561) | 3.76736771 |
| 24 | Increased serum lactate (HP:0002151) | 3.73521319 |
| 25 | Pallor (HP:0000980) | 3.52141309 |
| 26 | Aplastic anemia (HP:0001915) | 3.40252758 |
| 27 | Renal Fanconi syndrome (HP:0001994) | 3.37677389 |
| 28 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 3.24009472 |
| 29 | Oral leukoplakia (HP:0002745) | 3.19781282 |
| 30 | Lactic acidosis (HP:0003128) | 3.17181754 |
| 31 | Increased intramyocellular lipid droplets (HP:0012240) | 3.16855351 |
| 32 | Breast hypoplasia (HP:0003187) | 3.15609733 |
| 33 | Exertional dyspnea (HP:0002875) | 3.14253686 |
| 34 | Cerebral edema (HP:0002181) | 3.02936179 |
| 35 | Respiratory failure (HP:0002878) | 3.01859083 |
| 36 | Microvesicular hepatic steatosis (HP:0001414) | 2.99964030 |
| 37 | Exercise intolerance (HP:0003546) | 2.99354979 |
| 38 | Type I transferrin isoform profile (HP:0003642) | 2.69222787 |
| 39 | Leukodystrophy (HP:0002415) | 2.66145144 |
| 40 | Increased muscle lipid content (HP:0009058) | 2.61541432 |
| 41 | Pancreatic cysts (HP:0001737) | 2.59187910 |
| 42 | Rough bone trabeculation (HP:0100670) | 2.57938959 |
| 43 | Optic disc pallor (HP:0000543) | 2.53431161 |
| 44 | CNS demyelination (HP:0007305) | 2.53306654 |
| 45 | Abnormality of midbrain morphology (HP:0002418) | 2.52893747 |
| 46 | Molar tooth sign on MRI (HP:0002419) | 2.52893747 |
| 47 | Respiratory difficulties (HP:0002880) | 2.51283152 |
| 48 | Pancreatic fibrosis (HP:0100732) | 2.47216435 |
| 49 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.42891279 |
| 50 | Pancytopenia (HP:0001876) | 2.39610968 |
| 51 | True hermaphroditism (HP:0010459) | 2.36784908 |
| 52 | Carpal bone hypoplasia (HP:0001498) | 2.35702790 |
| 53 | Progressive microcephaly (HP:0000253) | 2.35587764 |
| 54 | Emotional lability (HP:0000712) | 2.35389294 |
| 55 | CNS hypomyelination (HP:0003429) | 2.34871777 |
| 56 | Methylmalonic aciduria (HP:0012120) | 2.29848948 |
| 57 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.23851126 |
| 58 | Secondary amenorrhea (HP:0000869) | 2.23627161 |
| 59 | Methylmalonic acidemia (HP:0002912) | 2.18469331 |
| 60 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.17237689 |
| 61 | Hyperglycinemia (HP:0002154) | 2.12330582 |
| 62 | Microretrognathia (HP:0000308) | 2.10352668 |
| 63 | Reduced antithrombin III activity (HP:0001976) | 2.10104600 |
| 64 | Generalized aminoaciduria (HP:0002909) | 2.08771310 |
| 65 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.05581187 |
| 66 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.05581187 |
| 67 | Abnormal protein glycosylation (HP:0012346) | 2.05581187 |
| 68 | Abnormal glycosylation (HP:0012345) | 2.05581187 |
| 69 | Premature ovarian failure (HP:0008209) | 2.04434057 |
| 70 | Testicular atrophy (HP:0000029) | 2.03940784 |
| 71 | Abnormality of alanine metabolism (HP:0010916) | 2.03747383 |
| 72 | Hyperalaninemia (HP:0003348) | 2.03747383 |
| 73 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.03747383 |
| 74 | Medial flaring of the eyebrow (HP:0010747) | 2.03421919 |
| 75 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.01084941 |
| 76 | Delusions (HP:0000746) | 1.98167715 |
| 77 | Ketoacidosis (HP:0001993) | 1.97991253 |
| 78 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.97921730 |
| 79 | Abnormality of methionine metabolism (HP:0010901) | 1.96562052 |
| 80 | Lethargy (HP:0001254) | 1.96318285 |
| 81 | Patellar aplasia (HP:0006443) | 1.96171002 |
| 82 | Abnormality of the anterior horn cell (HP:0006802) | 1.94872469 |
| 83 | Degeneration of anterior horn cells (HP:0002398) | 1.94872469 |
| 84 | Megaloblastic anemia (HP:0001889) | 1.94605073 |
| 85 | Severe visual impairment (HP:0001141) | 1.94429794 |
| 86 | Abnormality of renal resorption (HP:0011038) | 1.94031333 |
| 87 | Type II lissencephaly (HP:0007260) | 1.93851517 |
| 88 | Progressive muscle weakness (HP:0003323) | 1.93771142 |
| 89 | Abnormality of the ileum (HP:0001549) | 1.93687145 |
| 90 | Opisthotonus (HP:0002179) | 1.93469261 |
| 91 | Premature graying of hair (HP:0002216) | 1.92749492 |
| 92 | Irregular epiphyses (HP:0010582) | 1.92411077 |
| 93 | Poor head control (HP:0002421) | 1.91638799 |
| 94 | Nephronophthisis (HP:0000090) | 1.91485334 |
| 95 | Hypokinesia (HP:0002375) | 1.91104105 |
| 96 | Abnormality of reticulocytes (HP:0004312) | 1.90756720 |
| 97 | Unsteady gait (HP:0002317) | 1.89611430 |
| 98 | Sclerocornea (HP:0000647) | 1.88902304 |
| 99 | Multiple enchondromatosis (HP:0005701) | 1.88117622 |
| 100 | Postnatal microcephaly (HP:0005484) | 1.87203094 |
| 101 | Horseshoe kidney (HP:0000085) | 1.85973458 |
| 102 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.84983719 |
| 103 | Attenuation of retinal blood vessels (HP:0007843) | 1.84257498 |
| 104 | Abnormality of urine glucose concentration (HP:0011016) | 1.84154642 |
| 105 | Glycosuria (HP:0003076) | 1.84154642 |
| 106 | Abnormal trabecular bone morphology (HP:0100671) | 1.83784864 |
| 107 | Hyperphosphaturia (HP:0003109) | 1.79706188 |
| 108 | Congenital stationary night blindness (HP:0007642) | 1.79545398 |
| 109 | Hypoplasia of the pons (HP:0012110) | 1.79513656 |
| 110 | Abnormality of the preputium (HP:0100587) | 1.78062385 |
| 111 | Renal cortical cysts (HP:0000803) | 1.77691891 |
| 112 | Bone marrow hypocellularity (HP:0005528) | 1.77272102 |
| 113 | Dicarboxylic aciduria (HP:0003215) | 1.77117263 |
| 114 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.77117263 |
| 115 | Cellular immunodeficiency (HP:0005374) | 1.76899700 |
| 116 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.76542159 |
| 117 | Pendular nystagmus (HP:0012043) | 1.74876175 |
| 118 | Abnormality of serum amino acid levels (HP:0003112) | 1.74256228 |
| 119 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.74245716 |
| 120 | Poor suck (HP:0002033) | 1.74124930 |
| 121 | Chromsome breakage (HP:0040012) | 1.72301572 |
| 122 | 11 pairs of ribs (HP:0000878) | 1.71777009 |
| 123 | Hyperglycinuria (HP:0003108) | 1.70819869 |
| 124 | Meckel diverticulum (HP:0002245) | 1.70344836 |
| 125 | Trismus (HP:0000211) | 1.70176229 |
| 126 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.69625917 |
| 127 | Occipital encephalocele (HP:0002085) | 1.69368750 |
| 128 | Hypothermia (HP:0002045) | 1.69037091 |
| 129 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.68778189 |
| 130 | Absent thumb (HP:0009777) | 1.68470335 |
| 131 | IgM deficiency (HP:0002850) | 1.67708414 |
| 132 | Abnormality of the pons (HP:0007361) | 1.67584500 |
| 133 | Sensory axonal neuropathy (HP:0003390) | 1.67474144 |
| 134 | Gliosis (HP:0002171) | 1.67238606 |
| 135 | Ketosis (HP:0001946) | 1.66031832 |
| 136 | Furrowed tongue (HP:0000221) | 1.65651989 |
| 137 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.64893786 |
| 138 | Thrombocytosis (HP:0001894) | 1.63677943 |
| 139 | Abnormal lung lobation (HP:0002101) | 1.63571500 |
| 140 | Cleft eyelid (HP:0000625) | 1.63076557 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.78218499 |
| 2 | STK16 | 4.26049203 |
| 3 | NME2 | 4.12213759 |
| 4 | VRK2 | 3.83088599 |
| 5 | WEE1 | 3.81402246 |
| 6 | EIF2AK1 | 3.69255344 |
| 7 | MAP4K2 | 2.99861305 |
| 8 | SRPK1 | 2.81165160 |
| 9 | FRK | 2.78751604 |
| 10 | TRIM28 | 2.74762307 |
| 11 | EIF2AK3 | 2.63125310 |
| 12 | TLK1 | 2.56013909 |
| 13 | PIM2 | 2.36643205 |
| 14 | VRK1 | 2.31449153 |
| 15 | PDK2 | 2.10094099 |
| 16 | TSSK6 | 2.07202147 |
| 17 | NUAK1 | 2.06087107 |
| 18 | ACVR1B | 2.05959259 |
| 19 | NME1 | 2.04414233 |
| 20 | WNK3 | 1.95873646 |
| 21 | CDC7 | 1.91408084 |
| 22 | NEK1 | 1.78290179 |
| 23 | PLK4 | 1.74654848 |
| 24 | TESK2 | 1.69542209 |
| 25 | PBK | 1.63042197 |
| 26 | BRSK2 | 1.62621902 |
| 27 | CDK19 | 1.57454035 |
| 28 | MKNK1 | 1.56404307 |
| 29 | MST4 | 1.55262349 |
| 30 | ARAF | 1.53073629 |
| 31 | BMPR1B | 1.48718067 |
| 32 | WNK4 | 1.38841724 |
| 33 | MAP3K12 | 1.31410178 |
| 34 | PINK1 | 1.28856824 |
| 35 | CCNB1 | 1.28115788 |
| 36 | DYRK3 | 1.23529015 |
| 37 | BRSK1 | 1.22209914 |
| 38 | MAPKAPK3 | 1.18667416 |
| 39 | NEK2 | 1.15471915 |
| 40 | TNIK | 1.14837991 |
| 41 | BRAF | 1.14259005 |
| 42 | BCKDK | 1.14035922 |
| 43 | PLK1 | 1.13576090 |
| 44 | AURKA | 1.10628173 |
| 45 | KDR | 1.07507165 |
| 46 | DYRK2 | 1.04059241 |
| 47 | TTK | 1.02355756 |
| 48 | PNCK | 1.01818280 |
| 49 | MKNK2 | 1.00671083 |
| 50 | AURKB | 1.00448601 |
| 51 | INSRR | 0.99943351 |
| 52 | PHKG1 | 0.94485970 |
| 53 | PHKG2 | 0.94485970 |
| 54 | LIMK1 | 0.91156989 |
| 55 | MAP3K11 | 0.90396242 |
| 56 | CDK7 | 0.88766317 |
| 57 | CASK | 0.85026308 |
| 58 | PLK3 | 0.84349586 |
| 59 | PLK2 | 0.84064048 |
| 60 | EIF2AK2 | 0.83831468 |
| 61 | ABL2 | 0.82011195 |
| 62 | CSNK1G2 | 0.81904959 |
| 63 | ATR | 0.81803336 |
| 64 | CSNK1A1L | 0.81780557 |
| 65 | IRAK4 | 0.81208230 |
| 66 | ERBB3 | 0.79887353 |
| 67 | RPS6KA4 | 0.79746197 |
| 68 | CSNK1G3 | 0.79572204 |
| 69 | MYLK | 0.79207786 |
| 70 | PASK | 0.78715909 |
| 71 | CSNK2A1 | 0.77283655 |
| 72 | CSNK2A2 | 0.76622816 |
| 73 | SCYL2 | 0.74253010 |
| 74 | PAK1 | 0.73528516 |
| 75 | PRKCI | 0.68988084 |
| 76 | TAF1 | 0.67823150 |
| 77 | ILK | 0.67109785 |
| 78 | CDK8 | 0.66495729 |
| 79 | RPS6KB2 | 0.62612146 |
| 80 | RPS6KA5 | 0.59872773 |
| 81 | MAP2K6 | 0.56576918 |
| 82 | CHEK2 | 0.54834092 |
| 83 | SIK3 | 0.54808741 |
| 84 | CLK1 | 0.54746070 |
| 85 | MAP3K8 | 0.54057193 |
| 86 | DAPK1 | 0.53466306 |
| 87 | MAPKAPK5 | 0.53124718 |
| 88 | MUSK | 0.53085212 |
| 89 | MAP4K1 | 0.50737000 |
| 90 | PAK3 | 0.50490284 |
| 91 | BLK | 0.49702527 |
| 92 | LMTK2 | 0.48903063 |
| 93 | ATM | 0.48344178 |
| 94 | PRKCE | 0.48167727 |
| 95 | ZAK | 0.47106854 |
| 96 | IKBKB | 0.46917810 |
| 97 | MAPK13 | 0.45825292 |
| 98 | DAPK3 | 0.45093746 |
| 99 | BCR | 0.44841916 |
| 100 | MAP3K3 | 0.44312846 |
| 101 | PAK4 | 0.44089163 |
| 102 | CHEK1 | 0.43808244 |
| 103 | BTK | 0.42944623 |
| 104 | TESK1 | 0.42939325 |
| 105 | PRKCG | 0.42226513 |
| 106 | TEC | 0.41567749 |
| 107 | IRAK3 | 0.40734820 |
| 108 | PIM1 | 0.40153275 |
| 109 | FER | 0.39900047 |
| 110 | MAP2K7 | 0.39444438 |
| 111 | CAMK2D | 0.39005037 |
| 112 | MST1R | 0.38877598 |
| 113 | ADRBK2 | 0.38598371 |
| 114 | SYK | 0.38487392 |
| 115 | GRK5 | 0.37723649 |
| 116 | GRK7 | 0.37417688 |
| 117 | MAP2K3 | 0.37067349 |
| 118 | ADRBK1 | 0.36948464 |
| 119 | CDK11A | 0.36842067 |
| 120 | GRK6 | 0.35790533 |
| 121 | TXK | 0.35664649 |
| 122 | MAPK4 | 0.35184406 |
| 123 | LYN | 0.34840527 |
| 124 | CDK4 | 0.33886869 |
| 125 | STK4 | 0.33604819 |
| 126 | CSNK1G1 | 0.33497535 |
| 127 | CDK18 | 0.33062474 |
| 128 | CDK14 | 0.32462550 |
| 129 | LRRK2 | 0.31865606 |
| 130 | RAF1 | 0.31284796 |
| 131 | CSNK1A1 | 0.31073899 |
| 132 | CDK15 | 0.31032657 |
| 133 | STK39 | 0.29380281 |
| 134 | OXSR1 | 0.28824070 |
| 135 | ZAP70 | 0.28362748 |
| 136 | GRK1 | 0.27686479 |
| 137 | YES1 | 0.27041190 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.11248482 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.92139689 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 3.87326426 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.82209513 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.21878602 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 3.05040313 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.94110400 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.79962560 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.77676215 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.76872024 |
| 11 | Protein export_Homo sapiens_hsa03060 | 2.50327091 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.42013129 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.21319955 |
| 14 | Base excision repair_Homo sapiens_hsa03410 | 2.19134711 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 2.16305317 |
| 16 | RNA transport_Homo sapiens_hsa03013 | 2.05284627 |
| 17 | Alzheimers disease_Homo sapiens_hsa05010 | 1.85615791 |
| 18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.70536918 |
| 19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.68983267 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.65058625 |
| 21 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.63565829 |
| 22 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.57171164 |
| 23 | Purine metabolism_Homo sapiens_hsa00230 | 1.52730423 |
| 24 | Basal transcription factors_Homo sapiens_hsa03022 | 1.51897814 |
| 25 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.44159632 |
| 26 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.40790056 |
| 27 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.39831250 |
| 28 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.37286387 |
| 29 | Cell cycle_Homo sapiens_hsa04110 | 1.35456487 |
| 30 | RNA degradation_Homo sapiens_hsa03018 | 1.31724486 |
| 31 | Sulfur relay system_Homo sapiens_hsa04122 | 1.31169933 |
| 32 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.30691944 |
| 33 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.23503051 |
| 34 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.18933990 |
| 35 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.11980110 |
| 36 | Phototransduction_Homo sapiens_hsa04744 | 1.03257184 |
| 37 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.02344979 |
| 38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.00207096 |
| 39 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.00093235 |
| 40 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.97769219 |
| 41 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.97593325 |
| 42 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.92706869 |
| 43 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.88201910 |
| 44 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.87634032 |
| 45 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.84587920 |
| 46 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.83574246 |
| 47 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.82456641 |
| 48 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.76493141 |
| 49 | Metabolic pathways_Homo sapiens_hsa01100 | 0.76393886 |
| 50 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.74578776 |
| 51 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.72269301 |
| 52 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.72050321 |
| 53 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.71455953 |
| 54 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.69190318 |
| 55 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.67962387 |
| 56 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.65822429 |
| 57 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.64639395 |
| 58 | Carbon metabolism_Homo sapiens_hsa01200 | 0.63732249 |
| 59 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.63342775 |
| 60 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.62047097 |
| 61 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.61138763 |
| 62 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.58199859 |
| 63 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.57304801 |
| 64 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.57289282 |
| 65 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.56544591 |
| 66 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.53427678 |
| 67 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.52307785 |
| 68 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.52139398 |
| 69 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.50659834 |
| 70 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.48108665 |
| 71 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.46155900 |
| 72 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.44429900 |
| 73 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.43507856 |
| 74 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.43432648 |
| 75 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.42935475 |
| 76 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.42676981 |
| 77 | Allograft rejection_Homo sapiens_hsa05330 | 0.41295932 |
| 78 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.40780011 |
| 79 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.39808600 |
| 80 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.39734086 |
| 81 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.39028884 |
| 82 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.38465253 |
| 83 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.37268300 |
| 84 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.36761203 |
| 85 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.34911251 |
| 86 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.34901138 |
| 87 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.34777991 |
| 88 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.34248692 |
| 89 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.33290092 |
| 90 | Peroxisome_Homo sapiens_hsa04146 | 0.30746400 |
| 91 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.27835499 |
| 92 | Olfactory transduction_Homo sapiens_hsa04740 | 0.27361398 |
| 93 | Retinol metabolism_Homo sapiens_hsa00830 | 0.27188266 |
| 94 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.26520358 |
| 95 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.26268506 |
| 96 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.26258785 |
| 97 | Histidine metabolism_Homo sapiens_hsa00340 | 0.24015940 |
| 98 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.22648585 |
| 99 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.22565155 |
| 100 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.21259898 |
| 101 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.20280269 |
| 102 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.19973966 |
| 103 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.19348243 |
| 104 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.19207774 |
| 105 | Galactose metabolism_Homo sapiens_hsa00052 | 0.19111929 |
| 106 | Legionellosis_Homo sapiens_hsa05134 | 0.18940373 |
| 107 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.17576082 |
| 108 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.17484013 |
| 109 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.16869661 |
| 110 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.15542096 |
| 111 | Alcoholism_Homo sapiens_hsa05034 | 0.15300986 |
| 112 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.14825880 |
| 113 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.14045956 |
| 114 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.13403437 |
| 115 | Asthma_Homo sapiens_hsa05310 | 0.12466718 |
| 116 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.12232548 |
| 117 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.10910926 |
| 118 | Thyroid cancer_Homo sapiens_hsa05216 | 0.10874814 |
| 119 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.09598065 |
| 120 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.09377272 |
| 121 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.09299477 |
| 122 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.08642348 |

