PSMG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.35803524
2viral transcription (GO:0019083)6.45165444
3translational termination (GO:0006415)6.20545955
4DNA deamination (GO:0045006)6.13691640
5ribosomal small subunit biogenesis (GO:0042274)6.12452862
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.62677941
7cotranslational protein targeting to membrane (GO:0006613)5.53328356
8protein targeting to ER (GO:0045047)5.48709171
9translational elongation (GO:0006414)5.40862824
10maturation of SSU-rRNA (GO:0030490)5.33038007
11protein localization to endoplasmic reticulum (GO:0070972)5.21172948
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.19238314
13behavioral response to nicotine (GO:0035095)5.07267579
14viral life cycle (GO:0019058)4.90557853
15cellular protein complex disassembly (GO:0043624)4.81773608
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.80920933
17translational initiation (GO:0006413)4.73698563
18ribosomal large subunit biogenesis (GO:0042273)4.54665087
19telomere maintenance via semi-conservative replication (GO:0032201)4.36110104
20deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.28088712
21protein complex disassembly (GO:0043241)4.21767273
22translation (GO:0006412)4.12502955
23proteasome assembly (GO:0043248)4.06641424
24DNA strand elongation involved in DNA replication (GO:0006271)4.05600654
25ribonucleoprotein complex biogenesis (GO:0022613)4.01501099
26macromolecular complex disassembly (GO:0032984)4.00697655
27DNA strand elongation (GO:0022616)3.95373838
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.87629417
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.84159883
30telomere maintenance via recombination (GO:0000722)3.81613004
31nuclear-transcribed mRNA catabolic process (GO:0000956)3.71692189
32formation of translation preinitiation complex (GO:0001731)3.69583670
33pseudouridine synthesis (GO:0001522)3.67200128
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.60506137
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.59785046
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.58404161
37termination of RNA polymerase III transcription (GO:0006386)3.58404161
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58402143
39cellular component biogenesis (GO:0044085)3.55897320
40mannosylation (GO:0097502)3.54464621
41mRNA catabolic process (GO:0006402)3.53176472
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52667287
43protein targeting to membrane (GO:0006612)3.52209098
44cytochrome complex assembly (GO:0017004)3.52059054
45rRNA processing (GO:0006364)3.51250009
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.48648876
47ATP synthesis coupled proton transport (GO:0015986)3.48648876
48spliceosomal snRNP assembly (GO:0000387)3.40738517
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.40732125
50nucleotide-excision repair, DNA gap filling (GO:0006297)3.39965774
51preassembly of GPI anchor in ER membrane (GO:0016254)3.39538362
52telomere maintenance via telomere lengthening (GO:0010833)3.38751853
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37892923
54protein-cofactor linkage (GO:0018065)3.37279887
55electron transport chain (GO:0022900)3.36928540
56respiratory electron transport chain (GO:0022904)3.36345093
57rRNA metabolic process (GO:0016072)3.36210280
58DNA replication initiation (GO:0006270)3.35729717
59mitotic recombination (GO:0006312)3.35176543
60establishment of integrated proviral latency (GO:0075713)3.34393219
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33311097
62RNA catabolic process (GO:0006401)3.32876098
63water-soluble vitamin biosynthetic process (GO:0042364)3.27357049
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.27177023
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27144619
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27144619
67protein complex biogenesis (GO:0070271)3.27131090
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24486552
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24486552
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24486552
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24425433
72negative regulation of ligase activity (GO:0051352)3.24425433
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24151603
74mitochondrial respiratory chain complex I assembly (GO:0032981)3.23680574
75NADH dehydrogenase complex assembly (GO:0010257)3.23680574
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23680574
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22854900
78mitochondrial respiratory chain complex assembly (GO:0033108)3.20123456
79spliceosomal complex assembly (GO:0000245)3.19476749
80regulation of nuclear cell cycle DNA replication (GO:0033262)3.17557544
81iron-sulfur cluster assembly (GO:0016226)3.16163037
82metallo-sulfur cluster assembly (GO:0031163)3.16163037
83DNA replication checkpoint (GO:0000076)3.15500118
84kynurenine metabolic process (GO:0070189)3.15361534
85transcription-coupled nucleotide-excision repair (GO:0006283)3.14131162
86signal transduction involved in DNA damage checkpoint (GO:0072422)3.13946914
87signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13946914
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12889956
89viral mRNA export from host cell nucleus (GO:0046784)3.10970361
90signal transduction involved in cell cycle checkpoint (GO:0072395)3.10779935
91regulation of cellular amino acid metabolic process (GO:0006521)3.09246153
92response to pheromone (GO:0019236)3.08491096
937-methylguanosine mRNA capping (GO:0006370)3.08172435
94maturation of 5.8S rRNA (GO:0000460)3.05461780
95ribosome biogenesis (GO:0042254)3.04693337
96respiratory chain complex IV assembly (GO:0008535)3.04056982
97replication fork processing (GO:0031297)3.03598368
987-methylguanosine RNA capping (GO:0009452)3.03478244
99RNA capping (GO:0036260)3.03478244
100peptidyl-histidine modification (GO:0018202)3.02543047
101response to interferon-beta (GO:0035456)3.01846155
102rRNA modification (GO:0000154)3.01492275
103indole-containing compound catabolic process (GO:0042436)3.00325020
104indolalkylamine catabolic process (GO:0046218)3.00325020
105tryptophan catabolic process (GO:0006569)3.00325020
106ubiquinone biosynthetic process (GO:0006744)2.99840610
107protein neddylation (GO:0045116)2.99415200
108epithelial cilium movement (GO:0003351)2.98708241
109regulation of cilium movement (GO:0003352)2.98322776
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96940795
111indolalkylamine metabolic process (GO:0006586)2.96715869
112negative regulation of transcription regulatory region DNA binding (GO:2000678)2.95252330
113rRNA methylation (GO:0031167)2.92372773
114negative regulation of telomere maintenance (GO:0032205)2.89777514
115detection of light stimulus involved in visual perception (GO:0050908)2.89306317
116detection of light stimulus involved in sensory perception (GO:0050962)2.89306317
117base-excision repair, AP site formation (GO:0006285)2.86829784
118nucleobase biosynthetic process (GO:0046112)2.86648304
119GTP biosynthetic process (GO:0006183)2.86261335
120guanosine-containing compound biosynthetic process (GO:1901070)2.84673584
121kinetochore assembly (GO:0051382)2.84375331
122chaperone-mediated protein transport (GO:0072321)2.83246699
123regulation of mitochondrial translation (GO:0070129)2.83014388
124cornea development in camera-type eye (GO:0061303)2.82810178
125CENP-A containing nucleosome assembly (GO:0034080)2.81599876
126fucose catabolic process (GO:0019317)2.81279923
127L-fucose metabolic process (GO:0042354)2.81279923
128L-fucose catabolic process (GO:0042355)2.81279923
129ubiquinone metabolic process (GO:0006743)2.80245286
130purine nucleobase biosynthetic process (GO:0009113)2.79949445
131tRNA processing (GO:0008033)2.79500751
132RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79339781
133tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79339781
134pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77163858
135protein polyglutamylation (GO:0018095)2.76595966
136histone mRNA metabolic process (GO:0008334)2.76464670
137recombinational repair (GO:0000725)2.75965223
138tryptophan metabolic process (GO:0006568)2.75754380
139nonmotile primary cilium assembly (GO:0035058)2.75327114
140oxidative phosphorylation (GO:0006119)2.75118809
141double-strand break repair via homologous recombination (GO:0000724)2.74114528
142neural tube formation (GO:0001841)2.63303137
143tRNA modification (GO:0006400)2.63052323
144detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62785226
145chromatin remodeling at centromere (GO:0031055)2.62278360
146DNA damage response, detection of DNA damage (GO:0042769)2.61822350
147behavioral response to ethanol (GO:0048149)2.61702901
148reciprocal DNA recombination (GO:0035825)2.60888597
149reciprocal meiotic recombination (GO:0007131)2.60888597
150cellular ketone body metabolic process (GO:0046950)2.59261772
151DNA double-strand break processing (GO:0000729)2.58121131
152GPI anchor metabolic process (GO:0006505)2.57761097
153axoneme assembly (GO:0035082)2.55424489
154platelet dense granule organization (GO:0060155)2.54245418
155intracellular protein transmembrane import (GO:0044743)2.53103856
156RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51985308
157somite development (GO:0061053)2.50328674
158purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.45680592
159purine nucleoside triphosphate biosynthetic process (GO:0009145)2.44641350
160amino acid salvage (GO:0043102)2.43919688
161L-methionine salvage (GO:0071267)2.43919688
162L-methionine biosynthetic process (GO:0071265)2.43919688
163mitochondrial RNA metabolic process (GO:0000959)2.42657889
164regulation of telomere maintenance (GO:0032204)2.41956399
165hydrogen ion transmembrane transport (GO:1902600)2.41261570
166maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39364069
167regulation of mitotic spindle checkpoint (GO:1903504)2.39242893
168regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39242893
169negative regulation of DNA-dependent DNA replication (GO:2000104)2.38252485
170C-terminal protein lipidation (GO:0006501)2.37867807
171ATP biosynthetic process (GO:0006754)2.37474165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.63607050
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.36435464
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92545875
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79266989
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.78670355
6ZNF274_21170338_ChIP-Seq_K562_Hela3.77102839
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.58692423
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53060063
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.37061143
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.21930382
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.08107287
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04857241
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04758207
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.96826679
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90466587
16EZH2_22144423_ChIP-Seq_EOC_Human2.87419077
17VDR_22108803_ChIP-Seq_LS180_Human2.86426247
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77231966
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75644946
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69801897
21VDR_23849224_ChIP-Seq_CD4+_Human2.65430175
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62753308
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58136775
24XRN2_22483619_ChIP-Seq_HELA_Human2.47966580
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39383830
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35048532
27EWS_26573619_Chip-Seq_HEK293_Human2.32047917
28DCP1A_22483619_ChIP-Seq_HELA_Human2.28237096
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23879444
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23560945
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.18963992
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.17228030
33FOXP3_21729870_ChIP-Seq_TREG_Human2.17161630
34IGF1R_20145208_ChIP-Seq_DFB_Human2.16358411
35FUS_26573619_Chip-Seq_HEK293_Human2.13889524
36GBX2_23144817_ChIP-Seq_PC3_Human2.12808504
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10923051
38* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08576788
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06273025
40TTF2_22483619_ChIP-Seq_HELA_Human2.04291302
41ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03517301
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02088809
43GABP_19822575_ChIP-Seq_HepG2_Human2.00583648
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00244158
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98865670
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96462591
47ELK1_19687146_ChIP-ChIP_HELA_Human1.94648459
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92584267
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90107921
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.89065739
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82365234
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80477606
53* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78561465
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77582755
55TAF15_26573619_Chip-Seq_HEK293_Human1.73355604
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72987342
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72953902
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72330648
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71066456
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70483762
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70189859
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.69536513
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66980690
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65958205
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.64120830
66P300_19829295_ChIP-Seq_ESCs_Human1.61689261
67TP53_22573176_ChIP-Seq_HFKS_Human1.61537639
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60799937
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60339833
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59365742
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56173781
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.53324319
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.52823548
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52605859
75IRF1_19129219_ChIP-ChIP_H3396_Human1.46289569
76ER_23166858_ChIP-Seq_MCF-7_Human1.45538386
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45183922
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45168833
79CIITA_25753668_ChIP-Seq_RAJI_Human1.42308163
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42287251
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41466891
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.39862576
83SPI1_23547873_ChIP-Seq_NB4_Human1.39646138
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39606562
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38790914
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.36818576
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.36429348
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31665488
89RNF2_27304074_Chip-Seq_NSC_Mouse1.30828589
90BP1_19119308_ChIP-ChIP_Hs578T_Human1.29373091
91REST_21632747_ChIP-Seq_MESCs_Mouse1.28016789
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.27685309
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25380582
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24912084
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24190955
96VDR_21846776_ChIP-Seq_THP-1_Human1.22666137
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22294382
98* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22192090
99* CBP_20019798_ChIP-Seq_JUKART_Human1.22192090
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21401065
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20292202
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20162457
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20085083
104MYC_18940864_ChIP-ChIP_HL60_Human1.19286985
105IRF8_21731497_ChIP-ChIP_J774_Mouse1.17016006
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15757398
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15757398
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15073279
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14468692
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11836674
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11571756
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10967564
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10673130
114* FOXA1_25329375_ChIP-Seq_VCAP_Human1.09695145
115* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09695145
116NCOR_22424771_ChIP-Seq_293T_Human1.09279653
117PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08957024
118NANOG_19829295_ChIP-Seq_ESCs_Human1.08826182
119SOX2_19829295_ChIP-Seq_ESCs_Human1.08826182
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07809244
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.06552367
122TP63_19390658_ChIP-ChIP_HaCaT_Human1.06520264
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06462007
124BCAT_22108803_ChIP-Seq_LS180_Human1.05610170
125* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04108882
126KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03826430
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03715335
128STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02813452
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02604999
130SCL_19346495_ChIP-Seq_HPC-7_Human1.02269916
131* AR_20517297_ChIP-Seq_VCAP_Human1.02160643
132AR_25329375_ChIP-Seq_VCAP_Human1.02160458
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01451872
134MYC_22102868_ChIP-Seq_BL_Human1.00618368
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00021421
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99621671
137ERA_21632823_ChIP-Seq_H3396_Human0.99270571
138CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99146670
139* KDM5A_27292631_Chip-Seq_BREAST_Human0.98954274
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97770261
141PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97272012
142CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97066786
143TFEB_21752829_ChIP-Seq_HELA_Human0.96586133
144STAT3_23295773_ChIP-Seq_U87_Human0.96572505
145TCF4_22108803_ChIP-Seq_LS180_Human0.96491866
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96212437
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95729417
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94916641
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94752044
150TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93380880
151TCF4_23295773_ChIP-Seq_U87_Human0.92085665
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90194311
153HOXB7_26014856_ChIP-Seq_BT474_Human0.89368270
154SMAD4_21799915_ChIP-Seq_A2780_Human0.88922479
155EZH2_27304074_Chip-Seq_ESCs_Mouse0.88575666
156* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88526956
157NANOG_20526341_ChIP-Seq_ESCs_Human0.88513489
158SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88263971
159CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88052126
160* RUNX2_22187159_ChIP-Seq_PCA_Human0.87844662
161MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85450612
162GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85330709
163SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84512670
164DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83796341
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82111743
166SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82053723
167SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81895834
168AR_21909140_ChIP-Seq_LNCAP_Human0.79754314
169EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77839631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.29922524
2MP0009379_abnormal_foot_pigmentation3.86712096
3MP0004957_abnormal_blastocyst_morpholog3.19842727
4MP0001835_abnormal_antigen_presentation3.07592459
5MP0010094_abnormal_chromosome_stability3.04174815
6MP0008058_abnormal_DNA_repair3.00014913
7MP0008057_abnormal_DNA_replication2.83143094
8MP0003077_abnormal_cell_cycle2.80835476
9MP0002396_abnormal_hematopoietic_system2.80369147
10MP0003111_abnormal_nucleus_morphology2.45856947
11MP0008007_abnormal_cellular_replicative2.39346559
12MP0006292_abnormal_olfactory_placode2.36370333
13MP0001968_abnormal_touch/_nociception2.29043516
14MP0005174_abnormal_tail_pigmentation2.24823039
15MP0009785_altered_susceptibility_to2.23527025
16MP0005551_abnormal_eye_electrophysiolog2.23394249
17MP0000685_abnormal_immune_system2.22421014
18MP0003763_abnormal_thymus_physiology2.22252328
19MP0003787_abnormal_imprinting2.19480312
20MP0002148_abnormal_hypersensitivity_rea2.17614907
21MP0000490_abnormal_crypts_of2.14698172
22MP0005671_abnormal_response_to2.12572753
23MP0002736_abnormal_nociception_after2.07944435
24MP0006072_abnormal_retinal_apoptosis2.07328760
25MP0009333_abnormal_splenocyte_physiolog2.02121623
26MP0006276_abnormal_autonomic_nervous1.98309883
27MP0005646_abnormal_pituitary_gland1.95910162
28MP0005075_abnormal_melanosome_morpholog1.92452688
29MP0003186_abnormal_redox_activity1.88880830
30MP0008932_abnormal_embryonic_tissue1.86225305
31MP0002132_abnormal_respiratory_system1.76992995
32MP0003646_muscle_fatigue1.76859768
33MP0004142_abnormal_muscle_tone1.76640848
34MP0002398_abnormal_bone_marrow1.75743698
35MP0005025_abnormal_response_to1.72858776
36MP0002653_abnormal_ependyma_morphology1.71625436
37MP0002837_dystrophic_cardiac_calcinosis1.70456881
38MP0008875_abnormal_xenobiotic_pharmacok1.69487992
39MP0002163_abnormal_gland_morphology1.68646622
40MP0001986_abnormal_taste_sensitivity1.66740994
41MP0005000_abnormal_immune_tolerance1.66480853
42MP0009046_muscle_twitch1.65945383
43MP0005253_abnormal_eye_physiology1.64973760
44MP0001800_abnormal_humoral_immune1.61993093
45MP0000631_abnormal_neuroendocrine_gland1.61669454
46MP0003880_abnormal_central_pattern1.59761817
47MP0002420_abnormal_adaptive_immunity1.58464674
48MP0001819_abnormal_immune_cell1.58047862
49MP0005645_abnormal_hypothalamus_physiol1.57683286
50MP0002452_abnormal_antigen_presenting1.57516904
51MP0002638_abnormal_pupillary_reflex1.57181484
52MP0003195_calcinosis1.56873337
53MP0003786_premature_aging1.55272761
54MP0006036_abnormal_mitochondrial_physio1.55048819
55MP0002723_abnormal_immune_serum1.54963676
56MP0001853_heart_inflammation1.54894236
57MP0009745_abnormal_behavioral_response1.54679913
58MP0000689_abnormal_spleen_morphology1.52104942
59MP0004808_abnormal_hematopoietic_stem1.52047657
60MP0000716_abnormal_immune_system1.49632599
61MP0003436_decreased_susceptibility_to1.49600687
62MP0001545_abnormal_hematopoietic_system1.47176217
63MP0005397_hematopoietic_system_phenotyp1.47176217
64MP0002722_abnormal_immune_system1.46027702
65MP0002429_abnormal_blood_cell1.45809948
66MP0002234_abnormal_pharynx_morphology1.44748486
67MP0002095_abnormal_skin_pigmentation1.43456896
68MP0002160_abnormal_reproductive_system1.42920837
69MP0002272_abnormal_nervous_system1.41398551
70MP0000313_abnormal_cell_death1.40871895
71MP0008872_abnormal_physiological_respon1.38767179
72MP0003121_genomic_imprinting1.36242543
73MP0000372_irregular_coat_pigmentation1.35232108
74MP0002938_white_spotting1.33346018
75MP0008995_early_reproductive_senescence1.33015625
76MP0004043_abnormal_pH_regulation1.32089847
77MP0006035_abnormal_mitochondrial_morpho1.31974203
78MP0002019_abnormal_tumor_incidence1.31888271
79MP0002735_abnormal_chemical_nociception1.31488503
80MP0002405_respiratory_system_inflammati1.28993439
81MP0000703_abnormal_thymus_morphology1.28552338
82MP0001790_abnormal_immune_system1.27292039
83MP0005387_immune_system_phenotype1.27292039
84MP0000015_abnormal_ear_pigmentation1.26846796
85MP0000350_abnormal_cell_proliferation1.25100785
86MP0005389_reproductive_system_phenotype1.23644397
87MP0001485_abnormal_pinna_reflex1.22695295
88MP0002277_abnormal_respiratory_mucosa1.21215078
89MP0004145_abnormal_muscle_electrophysio1.20909826
90MP0003724_increased_susceptibility_to1.19370777
91MP0000427_abnormal_hair_cycle1.18206501
92MP0002419_abnormal_innate_immunity1.17439669
93MP0001529_abnormal_vocalization1.16266335
94MP0002876_abnormal_thyroid_physiology1.14114477
95MP0002557_abnormal_social/conspecific_i1.11607016
96MP0001486_abnormal_startle_reflex1.09752272
97MP0003315_abnormal_perineum_morphology1.08026528
98MP0005195_abnormal_posterior_eye1.07520947
99MP0005423_abnormal_somatic_nervous1.07483285
100MP0000778_abnormal_nervous_system1.06350448
101MP0002067_abnormal_sensory_capabilities1.05747838
102MP0002572_abnormal_emotion/affect_behav1.05163534
103MP0002733_abnormal_thermal_nociception1.04120656
104MP0002166_altered_tumor_susceptibility1.03196767
105MP0002064_seizures1.02966160
106MP0001919_abnormal_reproductive_system1.02803422
107MP0001970_abnormal_pain_threshold1.02631225
108MP0000858_altered_metastatic_potential1.02126975
109MP0002822_catalepsy1.01453063
110MP0005394_taste/olfaction_phenotype1.00838920
111MP0005499_abnormal_olfactory_system1.00838920
112MP0002006_tumorigenesis1.00110795
113MP0001188_hyperpigmentation0.99969464
114MP0003890_abnormal_embryonic-extraembry0.99792850
115MP0005085_abnormal_gallbladder_physiolo0.99427476
116MP0000569_abnormal_digit_pigmentation0.97951567
117MP0002752_abnormal_somatic_nervous0.97781099
118MP0004885_abnormal_endolymph0.97344930
119MP0005410_abnormal_fertilization0.97128453
120MP0002138_abnormal_hepatobiliary_system0.96952471
121MP0003698_abnormal_male_reproductive0.96229281
122MP0003866_abnormal_defecation0.96060324
123MP0001873_stomach_inflammation0.96016412
124MP0003567_abnormal_fetal_cardiomyocyte0.95901301
125MP0001929_abnormal_gametogenesis0.95308428
126MP0005379_endocrine/exocrine_gland_phen0.95028293
127MP0002734_abnormal_mechanical_nocicepti0.94727708
128MP0002184_abnormal_innervation0.94448311
129MP0001293_anophthalmia0.94019235
130MP0003718_maternal_effect0.93887119
131MP0001984_abnormal_olfaction0.93630467
132MP0000358_abnormal_cell_content/0.92802841
133MP0010155_abnormal_intestine_physiology0.92693726
134MP0006082_CNS_inflammation0.92169307
135MP0010386_abnormal_urinary_bladder0.91957852
136MP0004742_abnormal_vestibular_system0.91212625
137MP0003635_abnormal_synaptic_transmissio0.91160997
138MP0001501_abnormal_sleep_pattern0.91110247
139MP0001905_abnormal_dopamine_level0.90739734
140MP0005386_behavior/neurological_phenoty0.90638345
141MP0004924_abnormal_behavior0.90638345
142MP0003011_delayed_dark_adaptation0.89702423
143MP0000653_abnormal_sex_gland0.86735257
144MP0001730_embryonic_growth_arrest0.84323775
145MP0002102_abnormal_ear_morphology0.84176794
146MP0001845_abnormal_inflammatory_respons0.83260291
147MP0001764_abnormal_homeostasis0.82787324
148MP0005464_abnormal_platelet_physiology0.82444726
149MP0004133_heterotaxia0.78332601
150MP0000049_abnormal_middle_ear0.76505837
151MP0001348_abnormal_lacrimal_gland0.75829253
152MP0004147_increased_porphyrin_level0.75643321
153MP0008469_abnormal_protein_level0.75508985
154MP0005084_abnormal_gallbladder_morpholo0.75166089
155MP0003136_yellow_coat_color0.74881697
156MP0009697_abnormal_copulation0.74810000
157MP0002080_prenatal_lethality0.72349459
158MP0008877_abnormal_DNA_methylation0.72185447
159MP0003943_abnormal_hepatobiliary_system0.70685753
160MP0001186_pigmentation_phenotype0.68855810
161MP0002751_abnormal_autonomic_nervous0.68056375
162MP0001697_abnormal_embryo_size0.66375303
163MP0002210_abnormal_sex_determination0.64028582
164MP0003123_paternal_imprinting0.62769444
165MP0008789_abnormal_olfactory_epithelium0.62275711

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.22815388
2Abnormal number of erythroid precursors (HP:0012131)5.83521800
3Reticulocytopenia (HP:0001896)5.49171658
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.57887544
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.57887544
6Mitochondrial inheritance (HP:0001427)4.08197001
7Aplastic anemia (HP:0001915)4.06042706
8Pallor (HP:0000980)4.02257411
9Hepatocellular necrosis (HP:0001404)3.96517167
10Acute necrotizing encephalopathy (HP:0006965)3.91188268
11Pancreatic cysts (HP:0001737)3.88563121
12Abnormality of midbrain morphology (HP:0002418)3.88427085
13Molar tooth sign on MRI (HP:0002419)3.88427085
14Increased hepatocellular lipid droplets (HP:0006565)3.84583739
15Macrocytic anemia (HP:0001972)3.79529421
16Pancreatic fibrosis (HP:0100732)3.74274782
17Abnormal mitochondria in muscle tissue (HP:0008316)3.72380273
18Exertional dyspnea (HP:0002875)3.68281583
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.62559556
20Increased CSF lactate (HP:0002490)3.55422014
21Hepatic necrosis (HP:0002605)3.51486586
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.46366642
23True hermaphroditism (HP:0010459)3.42681044
24Type I transferrin isoform profile (HP:0003642)3.40371620
25Thrombocytosis (HP:0001894)3.36025504
26Lipid accumulation in hepatocytes (HP:0006561)3.33778779
27Congenital stationary night blindness (HP:0007642)3.31111518
28Nephronophthisis (HP:0000090)3.27206549
29Aplasia/Hypoplasia of the sacrum (HP:0008517)3.26679249
30Increased intramyocellular lipid droplets (HP:0012240)3.12746541
313-Methylglutaconic aciduria (HP:0003535)3.11689986
32Renal Fanconi syndrome (HP:0001994)3.09515235
33Increased serum lactate (HP:0002151)3.08224000
34Acute encephalopathy (HP:0006846)3.06567206
35Birth length less than 3rd percentile (HP:0003561)3.03924618
36Progressive macrocephaly (HP:0004481)2.99743201
37Oral leukoplakia (HP:0002745)2.98967353
38Reduced antithrombin III activity (HP:0001976)2.84490254
39Medial flaring of the eyebrow (HP:0010747)2.82281958
40IgM deficiency (HP:0002850)2.81441371
4111 pairs of ribs (HP:0000878)2.77533383
42Abnormality of the renal medulla (HP:0100957)2.77284374
43Exercise intolerance (HP:0003546)2.68736520
44Elevated erythrocyte sedimentation rate (HP:0003565)2.64584578
45Increased muscle lipid content (HP:0009058)2.57337036
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57123028
47Abnormality of alanine metabolism (HP:0010916)2.57123028
48Hyperalaninemia (HP:0003348)2.57123028
49Lactic acidosis (HP:0003128)2.53844526
50Abnormal protein glycosylation (HP:0012346)2.53465830
51Abnormal glycosylation (HP:0012345)2.53465830
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.53465830
53Abnormal protein N-linked glycosylation (HP:0012347)2.53465830
54Type II lissencephaly (HP:0007260)2.52277692
55Chronic hepatic failure (HP:0100626)2.52138636
56Hyperventilation (HP:0002883)2.46824640
57Respiratory difficulties (HP:0002880)2.46353609
58Sclerocornea (HP:0000647)2.44791814
59Rough bone trabeculation (HP:0100670)2.42341303
60Microretrognathia (HP:0000308)2.42136934
61Muscle fiber atrophy (HP:0100295)2.41438818
62Congenital, generalized hypertrichosis (HP:0004540)2.39542204
63Pendular nystagmus (HP:0012043)2.38566287
64Colon cancer (HP:0003003)2.38085411
65Abnormality of the heme biosynthetic pathway (HP:0010472)2.35313852
66Abolished electroretinogram (ERG) (HP:0000550)2.34913128
67Abnormality of the renal cortex (HP:0011035)2.34800675
68Cystic liver disease (HP:0006706)2.34520316
69Attenuation of retinal blood vessels (HP:0007843)2.33045253
70Poor head control (HP:0002421)2.31895632
71Pancytopenia (HP:0001876)2.31211405
72Respiratory failure (HP:0002878)2.30345069
73Premature graying of hair (HP:0002216)2.28308989
74Type 2 muscle fiber atrophy (HP:0003554)2.26981012
75Microvesicular hepatic steatosis (HP:0001414)2.26066696
76Gait imbalance (HP:0002141)2.19266163
77Anencephaly (HP:0002323)2.17305019
78Degeneration of anterior horn cells (HP:0002398)2.16982651
79Abnormality of the anterior horn cell (HP:0006802)2.16982651
80Congenital primary aphakia (HP:0007707)2.14508836
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.10928196
82Absent/shortened dynein arms (HP:0200106)2.10928196
83Absent thumb (HP:0009777)2.10588632
84Inability to walk (HP:0002540)2.10543769
85Polydipsia (HP:0001959)2.07752026
86Abnormal drinking behavior (HP:0030082)2.07752026
87Myelodysplasia (HP:0002863)2.06776416
88Bile duct proliferation (HP:0001408)2.06038967
89Abnormal biliary tract physiology (HP:0012439)2.06038967
90Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03519663
91Abnormality of the labia minora (HP:0012880)2.02505096
92Severe visual impairment (HP:0001141)2.01128353
93Congenital hepatic fibrosis (HP:0002612)2.00958885
94Male pseudohermaphroditism (HP:0000037)2.00901622
95Abnormal rod and cone electroretinograms (HP:0008323)2.00049841
96Chromsome breakage (HP:0040012)2.00046868
97Bone marrow hypocellularity (HP:0005528)1.99824897
98Renal cortical cysts (HP:0000803)1.99673287
99Decreased central vision (HP:0007663)1.99611868
100Myositis (HP:0100614)1.99489388
101Broad-based gait (HP:0002136)1.99153560
102Cleft eyelid (HP:0000625)1.99061252
103Hyperglycinemia (HP:0002154)1.98519569
104Gaze-evoked nystagmus (HP:0000640)1.98187928
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.97653804
106Abnormal number of incisors (HP:0011064)1.97417506
107Lymphoma (HP:0002665)1.97276532
108Breast hypoplasia (HP:0003187)1.96961376
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95867560
110Petechiae (HP:0000967)1.95238379
111Recurrent abscess formation (HP:0002722)1.95190845
112Patellar aplasia (HP:0006443)1.94385350
113Methylmalonic aciduria (HP:0012120)1.93722423
114Nephrogenic diabetes insipidus (HP:0009806)1.92801271
115Cerebellar dysplasia (HP:0007033)1.92753422
116Abnormal respiratory epithelium morphology (HP:0012253)1.90218455
117Abnormal respiratory motile cilium morphology (HP:0005938)1.90218455
118Methylmalonic acidemia (HP:0002912)1.89894997
119Tubular atrophy (HP:0000092)1.89640125
120Rib fusion (HP:0000902)1.89634023
121Cellular immunodeficiency (HP:0005374)1.89529515
122Optic nerve coloboma (HP:0000588)1.89444296
123Abnormality of renal resorption (HP:0011038)1.88951005
124Cerebral edema (HP:0002181)1.88176609
125Abnormality of glycolysis (HP:0004366)1.86977092
126Increased serum pyruvate (HP:0003542)1.86977092
127Abnormality of the preputium (HP:0100587)1.86610925
128Abnormality of T cell physiology (HP:0011840)1.86599099
129Lissencephaly (HP:0001339)1.83843144
130Retinal dysplasia (HP:0007973)1.83571566
131Optic disc pallor (HP:0000543)1.83529152
132Cerebral hypomyelination (HP:0006808)1.82888094
133Aplasia/Hypoplasia of the patella (HP:0006498)1.81555118
134Lethargy (HP:0001254)1.81471518
135Bony spicule pigmentary retinopathy (HP:0007737)1.80716472
136Abnormal trabecular bone morphology (HP:0100671)1.80445769
137Chronic otitis media (HP:0000389)1.80123375
138Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80088453
139Pachygyria (HP:0001302)1.79948544
140Postaxial foot polydactyly (HP:0001830)1.78294042
141Depressed nasal ridge (HP:0000457)1.77758593
142Multiple enchondromatosis (HP:0005701)1.76324167
143Preaxial hand polydactyly (HP:0001177)1.76305525
144IgG deficiency (HP:0004315)1.76190415
145Aplasia/Hypoplasia of the tibia (HP:0005772)1.76082329
146Progressive cerebellar ataxia (HP:0002073)1.75734439
147Triphalangeal thumb (HP:0001199)1.74449154
148Abnormality of the pons (HP:0007361)1.74008967
149Neutropenia (HP:0001875)1.73967107
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73392665
151Chorioretinal atrophy (HP:0000533)1.72563392
152Pulmonary fibrosis (HP:0002206)1.71730750
153Genital tract atresia (HP:0001827)1.71517483
154Asplenia (HP:0001746)1.71233449
155Panhypogammaglobulinemia (HP:0003139)1.70968243
156Selective tooth agenesis (HP:0001592)1.70879146
157Furrowed tongue (HP:0000221)1.70625882
158Hypoplasia of the pons (HP:0012110)1.70099137
159Progressive microcephaly (HP:0000253)1.69655442
160Abnormal ciliary motility (HP:0012262)1.68844544
161Meckel diverticulum (HP:0002245)1.68444391
162Leukodystrophy (HP:0002415)1.68114608
163Abnormality of the ileum (HP:0001549)1.66189798
164Abnormal lung lobation (HP:0002101)1.64229375
165Increased IgM level (HP:0003496)1.60600460
166Mediastinal lymphadenopathy (HP:0100721)1.60577008
167Microcytic anemia (HP:0001935)1.60565219
168Aplasia/Hypoplasia of the uvula (HP:0010293)1.60333648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.56555645
2NME24.22748111
3STK164.01890692
4BUB13.68108747
5WEE13.00728574
6MAP4K22.94344025
7NUAK12.67295648
8VRK12.64897599
9VRK22.64082286
10EIF2AK12.51202803
11PIM22.50407218
12WNK32.50171362
13ACVR1B2.29896633
14TLK12.24683267
15SRPK12.22570875
16MAPK132.15694762
17WNK42.10037375
18EIF2AK32.08060968
19GRK12.02356830
20TAOK31.92915283
21CASK1.87658977
22CDK81.85929163
23PINK11.84181833
24DYRK31.79757823
25INSRR1.70317203
26TESK21.67634745
27CDC71.66938391
28IRAK41.63709704
29KIT1.55468574
30MAP4K11.53565413
31FLT31.52256105
32TGFBR11.52010608
33PLK41.49851236
34PBK1.49171699
35TEC1.48248141
36PASK1.42161072
37NEK11.39328044
38CDK71.37188149
39KDR1.35960568
40NME11.33582058
41CDK191.33398916
42TAF11.31717797
43MAP3K41.31325679
44CCNB11.31250504
45OXSR11.30630016
46BTK1.26631689
47MAPK151.21416553
48RPS6KB21.21105091
49IKBKB1.19303775
50STK391.18059198
51CSF1R1.17961100
52MAP3K121.16905949
53BRSK21.16831317
54MKNK11.16674098
55PLK11.14819684
56MUSK1.13719167
57ATR1.10751275
58BMPR1B1.10592551
59RPS6KA41.10322913
60MAP2K71.08556039
61TXK1.07258450
62PIM11.06946018
63MARK11.06860355
64TIE11.04945967
65NEK21.04490494
66AURKB1.04104277
67ADRBK21.03942250
68BCKDK1.03110968
69EIF2AK20.98533727
70DYRK20.97573431
71BLK0.97508497
72MAPKAPK50.97267163
73JAK30.95485205
74LRRK20.93565258
75TRIM280.92184351
76ADRBK10.92068317
77IRAK30.91416798
78YES10.91152746
79TBK10.89438228
80CSNK1G10.88492229
81MAP3K110.87352378
82BRAF0.86704996
83SYK0.85611323
84MATK0.82964280
85ZAK0.82847580
86PRKCG0.82225276
87LYN0.81222459
88CSNK1G30.80224899
89CSNK1G20.78345909
90TSSK60.78208962
91CHEK20.77813815
92NLK0.77792138
93TNIK0.77180184
94ILK0.76725168
95TYK20.75510799
96MAP3K140.75446980
97SIK20.75130963
98STK40.74142128
99AURKA0.73946437
100CSNK2A10.71173259
101MST40.70874384
102ZAP700.70696915
103RPS6KA50.69001684
104ABL20.68747851
105CSNK1A1L0.67703793
106PAK40.66999936
107MKNK20.66040434
108CDK30.66005197
109PLK20.65834904
110TESK10.65749160
111CSNK2A20.63784170
112MYLK0.62279907
113SCYL20.62025143
114PNCK0.61889840
115PAK30.61684444
116DAPK10.60832495
117BCR0.58421123
118MAPKAPK30.58080526
119TTK0.57927430
120CDK40.56267094
121AKT30.56097606
122DAPK20.55709057
123IKBKE0.55340320
124PLK30.55291226
125PDK20.54631867
126GRK60.53242419
127PHKG10.51829540
128PHKG20.51829540
129CHUK0.50909937
130CSNK1A10.50762985
131LCK0.50661950
132CAMKK20.50208050
133SIK30.50168993
134PRKACA0.47081337
135PRKCE0.46755018
136MAP2K60.45359096
137PIK3CA0.44998145
138ATM0.44848910
139EPHA40.44495940
140IRAK10.43650143
141LIMK10.43515655
142PKN10.43238764
143BRSK10.42897353
144CAMK2A0.42764838
145PAK10.42763677
146ARAF0.42264265
147STK110.41987352
148NTRK30.41248720
149NTRK20.40558381
150PRKCQ0.40284952
151GRK50.39096169
152GRK70.35981521
153CAMK10.35885512
154PRKG20.35601921
155CSNK1E0.35445452
156CLK10.35128776
157CHEK10.34860562

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.65066818
2DNA replication_Homo sapiens_hsa030304.19578758
3Proteasome_Homo sapiens_hsa030504.00722087
4Mismatch repair_Homo sapiens_hsa034303.55425070
5RNA polymerase_Homo sapiens_hsa030203.41543667
6Spliceosome_Homo sapiens_hsa030402.86454062
7Homologous recombination_Homo sapiens_hsa034402.76817216
8Base excision repair_Homo sapiens_hsa034102.74655564
9Pyrimidine metabolism_Homo sapiens_hsa002402.60128449
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52736509
11Oxidative phosphorylation_Homo sapiens_hsa001902.50496586
12Nucleotide excision repair_Homo sapiens_hsa034202.46506970
13Parkinsons disease_Homo sapiens_hsa050122.44932184
14Protein export_Homo sapiens_hsa030602.41349543
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17327432
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03265756
17Huntingtons disease_Homo sapiens_hsa050161.83702382
18RNA transport_Homo sapiens_hsa030131.81945323
19RNA degradation_Homo sapiens_hsa030181.72408657
20Butanoate metabolism_Homo sapiens_hsa006501.68371276
21Nicotine addiction_Homo sapiens_hsa050331.66908767
22Fanconi anemia pathway_Homo sapiens_hsa034601.66774797
23Non-homologous end-joining_Homo sapiens_hsa034501.59820624
24Linoleic acid metabolism_Homo sapiens_hsa005911.59710439
25Nitrogen metabolism_Homo sapiens_hsa009101.55648744
26Basal transcription factors_Homo sapiens_hsa030221.55515837
27One carbon pool by folate_Homo sapiens_hsa006701.48582317
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48405690
29Caffeine metabolism_Homo sapiens_hsa002321.47139714
30Alzheimers disease_Homo sapiens_hsa050101.46319090
31Cell cycle_Homo sapiens_hsa041101.45371244
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43635844
33Sulfur relay system_Homo sapiens_hsa041221.43004758
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41510687
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38455085
36Purine metabolism_Homo sapiens_hsa002301.37282142
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.26867513
38Primary immunodeficiency_Homo sapiens_hsa053401.21466881
39Propanoate metabolism_Homo sapiens_hsa006401.18902056
40Tryptophan metabolism_Homo sapiens_hsa003801.15915707
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.15739221
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10611788
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08725727
44Folate biosynthesis_Homo sapiens_hsa007901.08645648
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07155756
46Peroxisome_Homo sapiens_hsa041461.05848841
47Taste transduction_Homo sapiens_hsa047421.05002467
48Olfactory transduction_Homo sapiens_hsa047401.02996584
49Allograft rejection_Homo sapiens_hsa053301.02574768
50Ether lipid metabolism_Homo sapiens_hsa005651.01872723
51Epstein-Barr virus infection_Homo sapiens_hsa051690.98119765
52Herpes simplex infection_Homo sapiens_hsa051680.95178494
53Chemical carcinogenesis_Homo sapiens_hsa052040.95098885
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95075646
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.93101542
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92595943
57Systemic lupus erythematosus_Homo sapiens_hsa053220.92094801
58p53 signaling pathway_Homo sapiens_hsa041150.91254171
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89735002
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86429884
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.86347466
62Antigen processing and presentation_Homo sapiens_hsa046120.81967459
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81422873
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81268087
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79564582
66Morphine addiction_Homo sapiens_hsa050320.78552184
67Steroid biosynthesis_Homo sapiens_hsa001000.77006606
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75557048
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74660091
70mRNA surveillance pathway_Homo sapiens_hsa030150.74191685
71Legionellosis_Homo sapiens_hsa051340.73041836
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72824745
73Graft-versus-host disease_Homo sapiens_hsa053320.72310055
74Retinol metabolism_Homo sapiens_hsa008300.71751155
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69717366
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68901205
77Measles_Homo sapiens_hsa051620.67884391
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67363563
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.66011511
80Pentose phosphate pathway_Homo sapiens_hsa000300.60233272
81N-Glycan biosynthesis_Homo sapiens_hsa005100.55360439
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54941029
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54754157
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.54119604
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53157646
86Glutamatergic synapse_Homo sapiens_hsa047240.51904300
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.51897580
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51747445
89Asthma_Homo sapiens_hsa053100.51194876
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49963408
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49913346
92Circadian entrainment_Homo sapiens_hsa047130.49124516
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48823281
94Hematopoietic cell lineage_Homo sapiens_hsa046400.48096102
95Autoimmune thyroid disease_Homo sapiens_hsa053200.48075710
96Metabolic pathways_Homo sapiens_hsa011000.48011665
97beta-Alanine metabolism_Homo sapiens_hsa004100.48007381
98Fat digestion and absorption_Homo sapiens_hsa049750.47440826
99Serotonergic synapse_Homo sapiens_hsa047260.46693754
100GABAergic synapse_Homo sapiens_hsa047270.46441103
101Cardiac muscle contraction_Homo sapiens_hsa042600.46201675
102Glutathione metabolism_Homo sapiens_hsa004800.45984671
103Type I diabetes mellitus_Homo sapiens_hsa049400.45703243
104Arachidonic acid metabolism_Homo sapiens_hsa005900.45443685
105Apoptosis_Homo sapiens_hsa042100.45344558
106Vitamin digestion and absorption_Homo sapiens_hsa049770.45279648
107ABC transporters_Homo sapiens_hsa020100.45178470
108Ovarian steroidogenesis_Homo sapiens_hsa049130.42385369
109Pyruvate metabolism_Homo sapiens_hsa006200.42230849
110Insulin secretion_Homo sapiens_hsa049110.42083367
111Leishmaniasis_Homo sapiens_hsa051400.41478287
112Shigellosis_Homo sapiens_hsa051310.41128203
113Salivary secretion_Homo sapiens_hsa049700.40915450
114Other glycan degradation_Homo sapiens_hsa005110.40745718
115Fatty acid elongation_Homo sapiens_hsa000620.40281625
116Glycerolipid metabolism_Homo sapiens_hsa005610.40267487
117Viral carcinogenesis_Homo sapiens_hsa052030.38689011
118Fatty acid degradation_Homo sapiens_hsa000710.38253732
119Hedgehog signaling pathway_Homo sapiens_hsa043400.37458316
120HTLV-I infection_Homo sapiens_hsa051660.36705303
121Fructose and mannose metabolism_Homo sapiens_hsa000510.35562919
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35208968
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35111335
124Galactose metabolism_Homo sapiens_hsa000520.35011566
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33838802
126Cocaine addiction_Homo sapiens_hsa050300.33061873
127Thyroid cancer_Homo sapiens_hsa052160.32922954
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32120638
129Influenza A_Homo sapiens_hsa051640.31105663
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.28506492
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28279404
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25879316
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24443232
134Alcoholism_Homo sapiens_hsa050340.24338525
135Hepatitis B_Homo sapiens_hsa051610.24024854
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21835360
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21655597
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.20578059
139Acute myeloid leukemia_Homo sapiens_hsa052210.19433857
140Phototransduction_Homo sapiens_hsa047440.19378071
141Pertussis_Homo sapiens_hsa051330.19174063
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18328310
143B cell receptor signaling pathway_Homo sapiens_hsa046620.17996236
144Biosynthesis of amino acids_Homo sapiens_hsa012300.17381091
145Selenocompound metabolism_Homo sapiens_hsa004500.16890924
146Regulation of autophagy_Homo sapiens_hsa041400.15485487
147Malaria_Homo sapiens_hsa051440.13314087
148Notch signaling pathway_Homo sapiens_hsa043300.08218304
149Renin-angiotensin system_Homo sapiens_hsa046140.07664309
150Sulfur metabolism_Homo sapiens_hsa009200.07428764

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