PSORS1C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.78794221
2virion attachment to host cell (GO:0019062)8.21770353
3adhesion of symbiont to host cell (GO:0044650)8.21770353
4citrulline biosynthetic process (GO:0019240)7.88285099
5peptide cross-linking (GO:0018149)7.69184467
6fatty acid elongation (GO:0030497)7.66320220
7regulation of dendritic cell antigen processing and presentation (GO:0002604)7.53367686
8hair follicle morphogenesis (GO:0031069)6.99180657
9adhesion of symbiont to host (GO:0044406)6.84202398
10keratinocyte differentiation (GO:0030216)6.09527424
11intermediate filament cytoskeleton organization (GO:0045104)6.08550413
12intermediate filament-based process (GO:0045103)5.89613104
13keratinocyte proliferation (GO:0043616)5.78790065
14imidazole-containing compound metabolic process (GO:0052803)5.65282611
15linoleic acid metabolic process (GO:0043651)5.56063795
16regulation of T-helper 1 cell differentiation (GO:0045625)5.55748340
17epidermis development (GO:0008544)5.51722098
18positive regulation of antigen processing and presentation (GO:0002579)5.36767187
19long-chain fatty acid biosynthetic process (GO:0042759)5.25419679
20cell wall macromolecule catabolic process (GO:0016998)5.08051421
21cell wall macromolecule metabolic process (GO:0044036)5.08051421
22citrulline metabolic process (GO:0000052)5.06791520
23bundle of His cell to Purkinje myocyte communication (GO:0086069)5.04705619
24positive regulation of Cdc42 GTPase activity (GO:0043089)4.93512686
25establishment of skin barrier (GO:0061436)4.89808604
26regulation of meiosis I (GO:0060631)4.85272679
27positive regulation of granulocyte chemotaxis (GO:0071624)4.78656292
28molting cycle process (GO:0022404)4.62735872
29hair cycle process (GO:0022405)4.62735872
30hemidesmosome assembly (GO:0031581)4.60429282
31epidermal cell differentiation (GO:0009913)4.60206675
32positive regulation of glycoprotein biosynthetic process (GO:0010560)4.53879238
33peptidyl-arginine modification (GO:0018195)4.48946782
34regulation of water loss via skin (GO:0033561)4.46293869
35lipoxygenase pathway (GO:0019372)4.43380387
36regulation of antigen processing and presentation (GO:0002577)4.39143703
37response to nitric oxide (GO:0071731)4.15978502
38cellular protein complex localization (GO:0034629)4.07895289
39skin morphogenesis (GO:0043589)4.06683616
40positive regulation of glycoprotein metabolic process (GO:1903020)4.04156643
41multicellular organismal water homeostasis (GO:0050891)3.87958223
42positive regulation of T-helper 1 type immune response (GO:0002827)3.85957777
43negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.78706569
44positive regulation of T-helper cell differentiation (GO:0045624)3.58068609
45piRNA metabolic process (GO:0034587)3.55670837
46skin development (GO:0043588)3.49330452
47positive regulation of neutrophil chemotaxis (GO:0090023)3.45726079
48positive regulation of neutrophil migration (GO:1902624)3.45726079
49phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.41422710
50response to prostaglandin E (GO:0034695)3.37214535
51long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.31993151
52regulation of retinoic acid receptor signaling pathway (GO:0048385)3.29740762
53ectoderm development (GO:0007398)3.29499359
54detection of bacterium (GO:0016045)3.29028906
55keratinocyte development (GO:0003334)3.28344013
56long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.19898432
57very long-chain fatty acid metabolic process (GO:0000038)3.19773468
58ribosomal small subunit assembly (GO:0000028)3.18624112
59peptide catabolic process (GO:0043171)3.17020972
60striated muscle atrophy (GO:0014891)3.12487836
61skeletal muscle adaptation (GO:0043501)3.11403420
62water homeostasis (GO:0030104)3.10834751
63tooth mineralization (GO:0034505)3.07109769
64positive regulation of epidermal cell differentiation (GO:0045606)3.05802751
65regulation of Cdc42 GTPase activity (GO:0043088)3.05788130
66male meiosis I (GO:0007141)3.00588252
67hair cycle (GO:0042633)29.6884986
68molting cycle (GO:0042303)29.6884986
69protein complex localization (GO:0031503)2.99328700
70skeletal muscle tissue regeneration (GO:0043403)2.96977975
71fatty-acyl-CoA biosynthetic process (GO:0046949)2.93922769
72retinol metabolic process (GO:0042572)2.93076543
73autophagic vacuole assembly (GO:0000045)2.92878832
74positive regulation of interleukin-1 beta secretion (GO:0050718)2.92492285
75hair follicle development (GO:0001942)2.92281928
76positive regulation of hair follicle development (GO:0051798)2.91801683
77positive regulation of hair cycle (GO:0042635)2.91801683
78regulation of epidermal cell differentiation (GO:0045604)2.87032186
79detection of other organism (GO:0098543)2.85182893
80positive regulation of keratinocyte differentiation (GO:0045618)2.81988473
81negative regulation of keratinocyte proliferation (GO:0010839)2.81463288
82regulation of hair follicle development (GO:0051797)2.81135333
83phosphatidylinositol acyl-chain remodeling (GO:0036149)2.80468789
84muscle atrophy (GO:0014889)2.79196046
85dendritic cell chemotaxis (GO:0002407)2.77025336
86negative regulation of meiosis (GO:0045835)2.76779964
87ribosomal small subunit biogenesis (GO:0042274)2.75775104
88regulation of granulocyte chemotaxis (GO:0071622)2.75699490
89regulation of cardioblast differentiation (GO:0051890)2.73415369
90collecting duct development (GO:0072044)2.73010492
91gap junction assembly (GO:0016264)2.72437517
92epithelium development (GO:0060429)2.72434522
93dendritic cell differentiation (GO:0097028)2.71389516
94positive regulation of interleukin-1 secretion (GO:0050716)2.70724809
95negative regulation of epidermal cell differentiation (GO:0045605)2.70401032
96aorta morphogenesis (GO:0035909)2.69475806
97regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.69131773
98transcription from mitochondrial promoter (GO:0006390)2.68214286
99regulation of natural killer cell differentiation (GO:0032823)2.67320015
100negative regulation of muscle hypertrophy (GO:0014741)2.66347935
101phosphatidylserine acyl-chain remodeling (GO:0036150)2.65735557
102regulation of T-helper 1 type immune response (GO:0002825)2.65606814
103regulation of epidermis development (GO:0045682)2.63939684
104meiosis I (GO:0007127)2.57752968
105positive regulation of interleukin-1 beta production (GO:0032731)2.57154045
106chaperone-mediated protein transport (GO:0072321)2.57091681
107phosphatidylserine metabolic process (GO:0006658)2.56227451
108negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.56218928
109regulation of keratinocyte differentiation (GO:0045616)2.55346218
110phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.55042413
111regulation of interleukin-1 beta secretion (GO:0050706)2.54065309
112acyl-CoA biosynthetic process (GO:0071616)2.53833255
113thioester biosynthetic process (GO:0035384)2.53833255
114response to prostaglandin (GO:0034694)2.52166096
115heterotypic cell-cell adhesion (GO:0034113)2.50793458
116positive regulation of NF-kappaB import into nucleus (GO:0042346)2.49762453
117negative regulation of skeletal muscle tissue development (GO:0048642)2.49070563
118ribosome assembly (GO:0042255)2.48843327
119positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.48545061
120synapsis (GO:0007129)2.47827807
121negative regulation of cell fate commitment (GO:0010454)2.45424092
122male meiosis (GO:0007140)2.44272426
123rRNA modification (GO:0000154)2.44165097
124formation of translation preinitiation complex (GO:0001731)2.42888113
125fatty-acyl-CoA metabolic process (GO:0035337)2.41738958
126regulation of keratinocyte proliferation (GO:0010837)2.41322924
127defense response to fungus (GO:0050832)2.39999691
128regulation of G0 to G1 transition (GO:0070316)2.39118097
129negative regulation of epidermis development (GO:0045683)2.39029011
130regulation of hair cycle (GO:0042634)2.38745005
131epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.38144442
132phosphatidylcholine acyl-chain remodeling (GO:0036151)2.37791419
133unsaturated fatty acid biosynthetic process (GO:0006636)2.37604914
134establishment of planar polarity (GO:0001736)2.37189540
135establishment of tissue polarity (GO:0007164)2.37189540
136positive regulation of epidermis development (GO:0045684)2.36822533
137mitotic metaphase plate congression (GO:0007080)2.35632012
138positive regulation of interleukin-1 production (GO:0032732)2.35257135
139regulation of T-helper cell differentiation (GO:0045622)2.34671425
140cytokine secretion (GO:0050663)2.34596944
141leukocyte tethering or rolling (GO:0050901)2.34122320
142negative regulation of interferon-gamma production (GO:0032689)2.33314023
143regulation of interleukin-1 secretion (GO:0050704)2.32854816
144regulation of neutrophil chemotaxis (GO:0090022)2.32481328
145regulation of neutrophil migration (GO:1902622)2.32481328
146regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.31704154
147negative regulation of cell fate specification (GO:0009996)2.29509790
148ncRNA 3-end processing (GO:0043628)2.27677778
149single strand break repair (GO:0000012)2.27672348
150regulation of transforming growth factor beta1 production (GO:0032908)2.26865392
151ribosomal large subunit biogenesis (GO:0042273)2.26814229
152regulation of chemokine secretion (GO:0090196)2.25589857
153lung-associated mesenchyme development (GO:0060484)2.22012192
154blastocyst development (GO:0001824)2.15754875
155polarized epithelial cell differentiation (GO:0030859)2.15322894
156ceramide biosynthetic process (GO:0046513)2.10877615
157regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.08115948
158morphogenesis of embryonic epithelium (GO:0016331)2.06907858
159alditol phosphate metabolic process (GO:0052646)2.04929939
160mitotic chromosome condensation (GO:0007076)2.03528815
161response to fungus (GO:0009620)2.03415835
162ventricular cardiac muscle cell development (GO:0055015)2.02042156
163intermediate filament organization (GO:0045109)11.4446900
164keratinization (GO:0031424)10.3122729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.74605968
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.61716104
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.53302226
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.05778290
5ZNF263_19887448_ChIP-Seq_K562_Human2.93281223
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.58970749
7CTCF_20526341_ChIP-Seq_ESCs_Human2.52953067
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43456497
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35381948
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35381948
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35381948
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07375278
13NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.03201232
14TP63_17297297_ChIP-ChIP_HaCaT_Human12.7704258
15MYC_18555785_ChIP-Seq_MESCs_Mouse1.98402221
16BCOR_27268052_Chip-Seq_Bcells_Human1.93267388
17TAF2_19829295_ChIP-Seq_ESCs_Human1.92958634
18BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.89849144
19P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.87361849
20CTCF_27219007_Chip-Seq_Bcells_Human1.82218423
21BCL6_27268052_Chip-Seq_Bcells_Human1.78455766
22* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.72890716
23ERG_20517297_ChIP-Seq_VCAP_Human1.72802049
24E2F1_20622854_ChIP-Seq_HELA_Human1.71079483
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69253988
26EGR1_19032775_ChIP-ChIP_M12_Human1.61533070
27NANOG_20526341_ChIP-Seq_ESCs_Human1.61482252
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.61292518
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.59161586
30TP53_20018659_ChIP-ChIP_R1E_Mouse1.58774131
31P53_21459846_ChIP-Seq_SAOS-2_Human1.57763945
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57645902
33E2F7_22180533_ChIP-Seq_HELA_Human1.57123679
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56644516
35MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.56638588
36RACK7_27058665_Chip-Seq_MCF-7_Human1.56496682
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.52860610
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51950622
39AR_21909140_ChIP-Seq_LNCAP_Human1.50191990
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49953150
41TP63_22573176_ChIP-Seq_HFKS_Human1.45330667
42LXR_22292898_ChIP-Seq_THP-1_Human1.44189141
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42042142
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41898716
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41227708
46SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.40392594
47YY1_22570637_ChIP-Seq_MALME-3M_Human1.38802370
48ATF3_27146783_Chip-Seq_COLON_Human1.37253499
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37114374
50ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35870621
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.35801528
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34497586
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33587410
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33322858
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33322858
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32404456
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32380303
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31560454
59PHF8_20622854_ChIP-Seq_HELA_Human1.31451198
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.29653699
61P68_20966046_ChIP-Seq_HELA_Human1.29519051
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.28217244
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27544973
64CEBPB_22108803_ChIP-Seq_LS180_Human1.25884288
65SMC4_20622854_ChIP-Seq_HELA_Human1.25778360
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.25598469
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23269629
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.21188640
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16410397
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.15416533
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15311346
72GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.14803313
73SPI1_20517297_ChIP-Seq_HL60_Human1.12453416
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10953661
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09912153
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.08760653
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08749903
78AHR_22903824_ChIP-Seq_MCF-7_Human1.07576066
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07469262
80STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06069092
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05811275
82RAC3_21632823_ChIP-Seq_H3396_Human1.04796729
83* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04404769
84RUNX1_27514584_Chip-Seq_MCF-7_Human1.03560462
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03157897
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.03026511
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01572758
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00129653
89GATA4_25053715_ChIP-Seq_YYC3_Human0.99600086
90EST1_17652178_ChIP-ChIP_JURKAT_Human0.99117615
91TP53_18474530_ChIP-ChIP_U2OS_Human0.98954110
92E2F1_17053090_ChIP-ChIP_MCF-7_Human0.98222335
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97555285
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97000347
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95865206
96FOXM1_23109430_ChIP-Seq_U2OS_Human0.95740179
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95630769
98NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94838380
99UBF1/2_26484160_Chip-Seq_HMECs_Human0.94331233
100* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93690592
101SOX2_21211035_ChIP-Seq_LN229_Human0.93425705
102HTT_18923047_ChIP-ChIP_STHdh_Human0.93058685
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92607682
104E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91733387
105VDR_22108803_ChIP-Seq_LS180_Human0.90370457
106KAP1_27257070_Chip-Seq_ESCs_Mouse0.90216013
107GATA3_24758297_ChIP-Seq_MCF-7_Human0.90207541
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89922723
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89540953
110TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89479227
111DCP1A_22483619_ChIP-Seq_HELA_Human0.89011330
112TP63_23658742_ChIP-Seq_EP156T_Human0.88921138
113THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88730872
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88695370
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88286894
116NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88252058
117GATA3_21878914_ChIP-Seq_MCF-7_Human0.87095259
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87018392
119EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86678376
120KLF5_25053715_ChIP-Seq_YYC3_Human0.85602019
121SOX2_20726797_ChIP-Seq_SW620_Human0.85291108
122RBPJ_21746931_ChIP-Seq_IB4_Human0.84883297
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84774954
124ERA_21632823_ChIP-Seq_H3396_Human0.84734288
125BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83603951
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82805411
127CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82730212
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82654294
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.82643512
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82322381
131JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81762319
132GATA6_21074721_ChIP-Seq_CACO-2_Human0.81430487
133OCT4_20526341_ChIP-Seq_ESCs_Human0.79960030
134TTF2_22483619_ChIP-Seq_HELA_Human0.79908647
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79535843
136FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79161077
137FOXA1_25329375_ChIP-Seq_VCAP_Human0.79161077
138JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78327726
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78300011
140P300_27268052_Chip-Seq_Bcells_Human0.78157155
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77794573
142FOXH1_21741376_ChIP-Seq_EPCs_Human0.77687534
143FOXH1_21741376_ChIP-Seq_ESCs_Human0.77442422
144CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.77313950
145RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76897451
146RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75709950
147SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.74780585
148GATA6_25053715_ChIP-Seq_YYC3_Human0.74617159
149* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.74365043
150RXR_22108803_ChIP-Seq_LS180_Human0.74237994
151SA1_27219007_Chip-Seq_Bcells_Human0.74196772
152* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73791681
153NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73680731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.02103033
2MP0002098_abnormal_vibrissa_morphology6.61618576
3MP0002796_impaired_skin_barrier5.80487114
4MP0000647_abnormal_sebaceous_gland5.68675497
5MP0005275_abnormal_skin_tensile5.05679797
6MP0002254_reproductive_system_inflammat4.89766303
7MP0009379_abnormal_foot_pigmentation4.69771317
8MP0010234_abnormal_vibrissa_follicle4.47146312
9MP0000383_abnormal_hair_follicle4.15624263
10MP0000377_abnormal_hair_follicle3.74587405
11MP0005501_abnormal_skin_physiology3.66208923
12MP0010678_abnormal_skin_adnexa3.65068538
13MP0003705_abnormal_hypodermis_morpholog3.33098132
14MP0000427_abnormal_hair_cycle3.24586057
15MP0001188_hyperpigmentation2.50304565
16MP0001216_abnormal_epidermal_layer2.49377021
17MP0000685_abnormal_immune_system2.39370196
18MP0003453_abnormal_keratinocyte_physiol2.28764986
19MP0003878_abnormal_ear_physiology2.27226114
20MP0005377_hearing/vestibular/ear_phenot2.27226114
21MP0000367_abnormal_coat/_hair2.22420419
22MP0010771_integument_phenotype2.15271086
23MP0002060_abnormal_skin_morphology2.09659233
24MP0004381_abnormal_hair_follicle2.06028321
25MP0004947_skin_inflammation2.04854383
26MP0000467_abnormal_esophagus_morphology1.98335039
27MP0001243_abnormal_dermal_layer1.88074516
28MP0002234_abnormal_pharynx_morphology1.87748372
29MP0001346_abnormal_lacrimal_gland1.62995894
30MP0002876_abnormal_thyroid_physiology1.59736757
31MP0008260_abnormal_autophagy1.50061991
32MP0005174_abnormal_tail_pigmentation1.40845060
33MP0000762_abnormal_tongue_morphology1.37428096
34MP0003566_abnormal_cell_adhesion1.36925884
35MP0001348_abnormal_lacrimal_gland1.32293465
36MP0002877_abnormal_melanocyte_morpholog1.31700552
37MP0009053_abnormal_anal_canal1.31236740
38MP0009931_abnormal_skin_appearance1.30236732
39MP0005647_abnormal_sex_gland1.27607558
40MP0004957_abnormal_blastocyst_morpholog1.24488125
41MP0003941_abnormal_skin_development1.22309657
42MP0000015_abnormal_ear_pigmentation1.21614379
43MP0003191_abnormal_cellular_cholesterol1.20662122
44MP0003011_delayed_dark_adaptation1.10410735
45MP0004782_abnormal_surfactant_physiolog1.09010858
46MP0003693_abnormal_embryo_hatching1.07726193
47MP0002160_abnormal_reproductive_system1.02964579
48MP0006035_abnormal_mitochondrial_morpho0.99340456
49MP0004264_abnormal_extraembryonic_tissu0.98129441
50MP0005645_abnormal_hypothalamus_physiol0.97085782
51MP0001191_abnormal_skin_condition0.92272761
52MP0006054_spinal_hemorrhage0.88961100
53MP0001986_abnormal_taste_sensitivity0.86766086
54MP0005423_abnormal_somatic_nervous0.86596485
55MP0005409_darkened_coat_color0.84059596
56MP0001851_eye_inflammation0.81610159
57MP0004510_myositis0.80613606
58MP0002735_abnormal_chemical_nociception0.79864205
59MP0010368_abnormal_lymphatic_system0.76885400
60MP0010352_gastrointestinal_tract_polyps0.76019945
61MP0003315_abnormal_perineum_morphology0.74316325
62MP0003646_muscle_fatigue0.73579210
63MP0004185_abnormal_adipocyte_glucose0.71116502
64MP0002970_abnormal_white_adipose0.70971190
65MP0008057_abnormal_DNA_replication0.70959282
66MP0002095_abnormal_skin_pigmentation0.69018322
67MP0003638_abnormal_response/metabolism_0.68537439
68MP0005310_abnormal_salivary_gland0.67620057
69MP0002089_abnormal_postnatal_growth/wei0.67027599
70MP0009333_abnormal_splenocyte_physiolog0.66390713
71MP0010030_abnormal_orbit_morphology0.66163963
72MP0003718_maternal_effect0.64654339
73MP0005503_abnormal_tendon_morphology0.63673035
74MP0000627_abnormal_mammary_gland0.63581617
75MP0000462_abnormal_digestive_system0.61607865
76MP0002138_abnormal_hepatobiliary_system0.59095473
77MP0001849_ear_inflammation0.58736261
78MP0010094_abnormal_chromosome_stability0.57481917
79MP0002249_abnormal_larynx_morphology0.55567056
80MP0001340_abnormal_eyelid_morphology0.53644944
81MP0003763_abnormal_thymus_physiology0.48792974
82MP0001835_abnormal_antigen_presentation0.47819213
83MP0003111_abnormal_nucleus_morphology0.47108423
84MP0004885_abnormal_endolymph0.46386256
85MP0001873_stomach_inflammation0.45580993
86MP0002282_abnormal_trachea_morphology0.45130306
87MP0003077_abnormal_cell_cycle0.44386032
88MP0000358_abnormal_cell_content/0.44311621
89MP0003045_fibrosis0.43887251
90MP0008058_abnormal_DNA_repair0.42790997
91MP0003755_abnormal_palate_morphology0.41601924
92MP0000470_abnormal_stomach_morphology0.40274992
93MP0002697_abnormal_eye_size0.39909948
94MP0002177_abnormal_outer_ear0.39461221
95MP0000003_abnormal_adipose_tissue0.39401895
96MP0002111_abnormal_tail_morphology0.39227226
97MP0005389_reproductive_system_phenotype0.37917584
98MP0002971_abnormal_brown_adipose0.37312674
99MP0001730_embryonic_growth_arrest0.36863669
100MP0000678_abnormal_parathyroid_gland0.36693395
101MP0001784_abnormal_fluid_regulation0.36323232
102MP0002210_abnormal_sex_determination0.36182615
103MP0005023_abnormal_wound_healing0.36130983
104MP0004019_abnormal_vitamin_homeostasis0.35968631
105MP0003300_gastrointestinal_ulcer0.35719245
106MP0001485_abnormal_pinna_reflex0.34750055
107MP0003806_abnormal_nucleotide_metabolis0.34674711
108MP0008932_abnormal_embryonic_tissue0.32865955
109MP0003950_abnormal_plasma_membrane0.32087578
110MP0008438_abnormal_cutaneous_collagen0.31258853
111MP0000566_synostosis0.30835055
112MP0004197_abnormal_fetal_growth/weight/0.30683935
113MP0003890_abnormal_embryonic-extraembry0.30520865
114MP0002108_abnormal_muscle_morphology0.28891023
115MP0009780_abnormal_chondrocyte_physiolo0.28667813
116MP0003937_abnormal_limbs/digits/tail_de0.28111421
117MP0003959_abnormal_lean_body0.26838993
118MP0000350_abnormal_cell_proliferation0.26603627
119MP0000750_abnormal_muscle_regeneration0.26531764
120MP0001672_abnormal_embryogenesis/_devel0.25811564
121MP0005380_embryogenesis_phenotype0.25811564
122MP0001177_atelectasis0.25401610
123MP0001929_abnormal_gametogenesis0.25000435
124MP0004272_abnormal_basement_membrane0.24748254
125MP0003448_altered_tumor_morphology0.24634616
126MP0001661_extended_life_span0.23818943
127MP0003186_abnormal_redox_activity0.23308911
128MP0005367_renal/urinary_system_phenotyp0.22728059
129MP0000516_abnormal_urinary_system0.22728059
130MP0005375_adipose_tissue_phenotype0.21961699
131MP0002084_abnormal_developmental_patter0.20889010
132MP0009115_abnormal_fat_cell0.20630882
133MP0002086_abnormal_extraembryonic_tissu0.20349680
134MP0005671_abnormal_response_to0.20064107
135MP0003385_abnormal_body_wall0.19465573
136MP0005451_abnormal_body_composition0.19170784
137MP0001145_abnormal_male_reproductive0.18894275
138MP0002085_abnormal_embryonic_tissue0.18533118
139MP0002896_abnormal_bone_mineralization0.18268524
140MP0000653_abnormal_sex_gland0.18218227
141MP0009672_abnormal_birth_weight0.17867198
142MP0002080_prenatal_lethality0.17840182
143MP0001853_heart_inflammation0.17594757
144MP0005076_abnormal_cell_differentiation0.17517570
145MP0002733_abnormal_thermal_nociception0.17420753
146MP0005452_abnormal_adipose_tissue0.17339698
147MP0002163_abnormal_gland_morphology0.16820258
148MP0005075_abnormal_melanosome_morpholog0.16296783
149MP0005666_abnormal_adipose_tissue0.15372695

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)9.19309327
2Pili torti (HP:0003777)7.98396085
3Nail dystrophy (HP:0008404)7.09048162
4Increased IgE level (HP:0003212)6.48657514
5Abnormality of nail color (HP:0100643)6.09100398
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.75064865
7Palmoplantar hyperkeratosis (HP:0000972)5.62715187
8Fragile nails (HP:0001808)5.42573350
9Palmar hyperkeratosis (HP:0010765)5.31345630
10Plantar hyperkeratosis (HP:0007556)5.20165849
11Onycholysis (HP:0001806)5.13999949
12Abnormal hair laboratory examination (HP:0003328)5.10461493
13Fine hair (HP:0002213)4.86980503
14Thick nail (HP:0001805)4.39247659
15Alopecia of scalp (HP:0002293)4.38443266
16Right ventricular cardiomyopathy (HP:0011663)4.33825028
17Absent hair (HP:0002298)4.30105819
18Abnormality of the axillary hair (HP:0100134)4.25393542
19Abnormality of secondary sexual hair (HP:0009888)4.25393542
20Absent eyebrow (HP:0002223)3.89403799
21Conjunctival hamartoma (HP:0100780)3.78410593
22Oral leukoplakia (HP:0002745)3.76213011
23Erythema (HP:0010783)3.70545024
24Follicular hyperkeratosis (HP:0007502)3.56558551
25Milia (HP:0001056)3.55395554
26Sparse eyelashes (HP:0000653)3.30186188
27Amelogenesis imperfecta (HP:0000705)3.18563939
28Ridged nail (HP:0001807)3.06934140
29Erythroderma (HP:0001019)2.90540335
30Abnormality of the frontal sinuses (HP:0002687)2.71976683
31Hamartoma of the eye (HP:0010568)2.67708291
32Curly hair (HP:0002212)2.65287387
33Dry hair (HP:0011359)2.61637202
34Abnormal blistering of the skin (HP:0008066)2.55229391
35Aplasia cutis congenita (HP:0001057)2.52170106
36Abnormality of the salivary glands (HP:0010286)2.47412239
37Neck muscle weakness (HP:0000467)2.39002164
38Congenital ichthyosiform erythroderma (HP:0007431)2.36135461
39Natal tooth (HP:0000695)2.33702204
40Parakeratosis (HP:0001036)2.32729416
41Ventricular tachycardia (HP:0004756)2.29603019
42Keratoconjunctivitis (HP:0001096)2.25970293
43Congenital, generalized hypertrichosis (HP:0004540)2.22557624
44Hypohidrosis (HP:0000966)2.20393200
45Amniotic constriction ring (HP:0009775)2.19494915
46Abnormality of placental membranes (HP:0011409)2.19494915
47Palmoplantar keratoderma (HP:0000982)2.18748274
48Fatigable weakness (HP:0003473)2.09422225
49Abnormality of the neuromuscular junction (HP:0003398)2.09422225
50Hypergammaglobulinemia (HP:0010702)2.08333750
51Pruritus (HP:0000989)2.07336672
52Abnormality of the aortic arch (HP:0012303)2.06664887
53Intention tremor (HP:0002080)2.04846817
54Gangrene (HP:0100758)2.03226545
55Advanced eruption of teeth (HP:0006288)2.00233944
56Hypotrichosis (HP:0001006)13.6790904
57Abnormality of hair growth rate (HP:0011363)10.0924657
58Slow-growing hair (HP:0002217)10.0924657
59Woolly hair (HP:0002224)10.0422348
60Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.98070948
61Abnormality of the parietal bone (HP:0002696)1.92488760
62Corneal erosion (HP:0200020)1.91814291
63Furrowed tongue (HP:0000221)1.90428189
64Abnormality of the gastric mucosa (HP:0004295)1.87063285
65Torticollis (HP:0000473)1.84936634
66Aplasia/Hypoplasia of the spleen (HP:0010451)1.81499668
67Abnormality of the renal collecting system (HP:0004742)1.81116813
68Abnormality of the phalanges of the 5th finger (HP:0004213)1.78997509
69Septate vagina (HP:0001153)1.78961696
70Concave nail (HP:0001598)1.78464374
71Unilateral renal agenesis (HP:0000122)1.77295454
72Difficulty walking (HP:0002355)1.76497936
73Abnormality of the pupil (HP:0000615)1.76041587
74Breast hypoplasia (HP:0003187)1.71840165
75Duplicated collecting system (HP:0000081)1.70608151
76Multifactorial inheritance (HP:0001426)1.67807643
77Laryngomalacia (HP:0001601)1.67510351
78Carpal bone hypoplasia (HP:0001498)1.66235854
79Abnormality of dental color (HP:0011073)1.62329995
80Lip pit (HP:0100267)1.59475271
81Hyperhidrosis (HP:0000975)1.58941141
82Blepharitis (HP:0000498)1.57843950
83Symphalangism affecting the phalanges of the hand (HP:0009773)1.56355799
84Trismus (HP:0000211)1.55090818
85Nasolacrimal duct obstruction (HP:0000579)1.54949967
86Abnormality of the fingernails (HP:0001231)1.53969686
87Eczematoid dermatitis (HP:0000976)1.53844808
88Abnormality of the costochondral junction (HP:0000919)1.53072677
89Urticaria (HP:0001025)1.51337769
90Craniofacial dystonia (HP:0012179)1.50441906
91Abnormality of the dental pulp (HP:0006479)1.50081645
92Neonatal death (HP:0003811)1.48395770
93Keratoconjunctivitis sicca (HP:0001097)1.47857477
94Upper limb muscle weakness (HP:0003484)1.46709715
95Absent eyelashes (HP:0000561)1.46111452
96Acanthosis nigricans (HP:0000956)1.45784202
97Premature loss of primary teeth (HP:0006323)1.45725634
98Ventricular fibrillation (HP:0001663)1.45149747
99Ureteral duplication (HP:0000073)1.44569270
100Anonychia (HP:0001798)1.44386964
101Ectropion (HP:0000656)1.44368269
102Lack of skin elasticity (HP:0100679)1.43642067
103Abnormality of permanent molar morphology (HP:0011071)1.43488776
104Abnormality of the dental root (HP:0006486)1.43488776
105Taurodontia (HP:0000679)1.43488776
106Abnormality of molar (HP:0011077)1.41930933
107Abnormality of molar morphology (HP:0011070)1.41930933
108Carious teeth (HP:0000670)1.41031154
109Widely patent fontanelles and sutures (HP:0004492)1.40737077
110Selective tooth agenesis (HP:0001592)1.39116304
111Heterogeneous (HP:0001425)1.39047498
112Hypoplastic labia majora (HP:0000059)1.38417819
113Dehydration (HP:0001944)1.38331405
114Fragile skin (HP:0001030)1.38130413
115Squamous cell carcinoma (HP:0002860)1.38101906
116Type I diabetes mellitus (HP:0100651)1.37908384
117Autoamputation (HP:0001218)1.37248098
118Sparse scalp hair (HP:0002209)1.37015727
119Split foot (HP:0001839)1.35091161
120Recurrent bacterial skin infections (HP:0005406)1.34260453
121Focal dystonia (HP:0004373)1.34182887
122Supernumerary nipples (HP:0002558)1.33197567
123Hyporeflexia of lower limbs (HP:0002600)1.33099243
124Double outlet right ventricle (HP:0001719)1.32322762
125Congenital malformation of the right heart (HP:0011723)1.32322762
126Distal lower limb muscle weakness (HP:0009053)1.32088870
127Fused cervical vertebrae (HP:0002949)1.28880378
128Abnormality of the labia majora (HP:0012881)1.25403506
129Stenosis of the external auditory canal (HP:0000402)1.25337595
130Paralysis (HP:0003470)1.24494285
131Aplasia/hypoplasia of the uterus (HP:0008684)1.24003263
132Recurrent corneal erosions (HP:0000495)1.21448928
133Corneal dystrophy (HP:0001131)1.18847850
134Premature ovarian failure (HP:0008209)1.18423266
135Microvesicular hepatic steatosis (HP:0001414)1.17385927
136Hypoplasia of the uterus (HP:0000013)1.17174512
137Delayed epiphyseal ossification (HP:0002663)1.16503531
138Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.14478683
139Abnormality of the lacrimal duct (HP:0011481)1.14014702
140Skin ulcer (HP:0200042)1.11285091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.65041257
2EPHA25.21808938
3ERN14.44725043
4DYRK34.39095194
5ACVR1B4.26517914
6MAP3K63.86982933
7DYRK1B3.75351651
8FER3.23988546
9BUB13.11933210
10LATS12.78078244
11CDK192.70649718
12TTK2.67107229
13LATS22.58596263
14MAPKAPK32.55801407
15STK162.18194056
16TAOK12.14563853
17SRPK12.10433133
18RPS6KB21.97762272
19MAP3K31.96077695
20MAP3K141.94057052
21EPHB21.88656159
22LMTK21.84752158
23BCR1.84140869
24NME11.66703075
25MAP3K91.65159270
26TESK21.63986484
27STK31.59769967
28PIK3CG1.57364638
29STK38L1.54626810
30PLK41.54289059
31ERBB31.45586369
32LRRK21.44048057
33NME21.38285991
34MAP2K61.35064560
35TTN1.34809516
36MAP3K111.34708576
37EPHB11.30272747
38VRK21.29931109
39PLK11.26531289
40STK101.25546557
41MAP3K21.18276459
42ZAK1.14194928
43PINK11.11979408
44AURKA1.10565229
45SCYL21.10434348
46PDK21.10147884
47BRSK11.10112012
48BLK1.10025837
49MET1.09042489
50AURKB1.04744851
51FGFR41.04715877
52PRKCI1.02120305
53MAP3K81.01617575
54CDC42BPA1.00036004
55IRAK40.98352270
56PTK20.97274108
57STK390.96415436
58KSR20.96194787
59EPHA30.94662251
60PDGFRA0.94304265
61EIF2AK30.90366353
62MAPKAPK20.90260618
63BMPR20.89874006
64ERBB40.89056402
65BMX0.87013835
66MST40.86083686
67CDK60.85078021
68WNK10.84075530
69EEF2K0.83813598
70TNK20.83535257
71PTK60.81676627
72ABL20.81528936
73NEK10.80867345
74DDR20.79447304
75SGK4940.79080017
76SGK2230.79080017
77TRIB30.77997338
78BRSK20.77243299
79TYK20.75821561
80PLK30.72712689
81PAK40.72159250
82STK40.71875117
83EPHA40.71568656
84CDK70.71372051
85FGFR10.70157700
86NTRK10.69825176
87NEK60.68486660
88BRAF0.68330456
89DYRK1A0.68272705
90PIM20.68208933
91NEK20.67084094
92CDK120.64972424
93FGFR30.64488047
94TESK10.63420422
95ALK0.63044774
96BCKDK0.62364448
97MARK30.60327202
98SMG10.60037841
99MAP2K30.59019998
100EIF2AK10.58377180
101MST1R0.57564366
102IKBKE0.56839344
103CHEK20.56361668
104STK240.55828648
105TGFBR10.54964523
106CHEK10.53781330
107MAP3K70.52851700
108MAP3K100.51951285
109NEK90.49874376
110RPS6KA10.48973815
111OBSCN0.48822632
112PAK60.47790429
113NTRK20.47503155
114RPS6KB10.46701640
115SYK0.46237827
116RPS6KA40.46069138
117PNCK0.45835164
118STK380.45435015
119PAK30.44304366
120PAK20.43976334
121RIPK10.43681110
122MAP2K10.42454488
123CSNK1E0.42430377
124JAK20.41377627
125TRIM280.40435790
126FGFR20.40142586
127PRKD10.39668358
128MAPKAPK50.39532884
129ARAF0.39061299
130ILK0.38433303
131CDC70.37969184
132MELK0.37747022
133CSNK2A10.35662651
134TSSK60.34899204
135NLK0.34457953
136RAF10.33062820
137CHUK0.32418643
138KSR10.31979423
139PAK10.31803982
140MAP3K10.31738872
141WEE10.31737420
142PRKCD0.31662635
143MATK0.31651390
144CDK80.31513602
145ATM0.29307191
146MAP2K20.28948443
147LIMK10.28651927
148MTOR0.27669992
149GRK60.27641032
150ROCK20.27109024
151GSK3A0.26894705
152PRKDC0.25932345
153PRKD20.25582015
154PIM10.25439706
155PRKCQ0.24457002
156YES10.24235858
157ICK0.23980949
158SRC0.23379952
159WNK40.22816764
160CSNK2A20.21010208

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005915.64240928
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.58344353
3Histidine metabolism_Homo sapiens_hsa003404.35428128
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.56680471
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38942141
6Fat digestion and absorption_Homo sapiens_hsa049753.15535579
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05609440
8Phenylalanine metabolism_Homo sapiens_hsa003602.86113643
9Ether lipid metabolism_Homo sapiens_hsa005652.85012611
10Regulation of autophagy_Homo sapiens_hsa041402.74362851
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.49547974
12Basal cell carcinoma_Homo sapiens_hsa052172.45754372
13Arachidonic acid metabolism_Homo sapiens_hsa005902.31088601
14Folate biosynthesis_Homo sapiens_hsa007902.26054969
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.18704901
16DNA replication_Homo sapiens_hsa030302.16508512
17Mismatch repair_Homo sapiens_hsa034302.12748141
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.98132106
19RNA polymerase_Homo sapiens_hsa030201.89161307
20Hedgehog signaling pathway_Homo sapiens_hsa043401.67840124
21Fatty acid elongation_Homo sapiens_hsa000621.67644740
22RNA transport_Homo sapiens_hsa030131.65870224
23Sphingolipid metabolism_Homo sapiens_hsa006001.59570442
24Antigen processing and presentation_Homo sapiens_hsa046121.56541889
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56523310
26Basal transcription factors_Homo sapiens_hsa030221.45267672
27Hippo signaling pathway_Homo sapiens_hsa043901.39604302
28p53 signaling pathway_Homo sapiens_hsa041151.37432667
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.35632571
30Tyrosine metabolism_Homo sapiens_hsa003501.28832211
31Retinol metabolism_Homo sapiens_hsa008301.27653817
32Cell cycle_Homo sapiens_hsa041101.23821052
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22217665
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19609027
35Base excision repair_Homo sapiens_hsa034101.17720809
36mRNA surveillance pathway_Homo sapiens_hsa030151.17545346
37VEGF signaling pathway_Homo sapiens_hsa043701.16838519
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15887596
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.14774673
40Phototransduction_Homo sapiens_hsa047441.11809833
41Proteasome_Homo sapiens_hsa030501.08190148
42Adherens junction_Homo sapiens_hsa045201.06181857
43Melanogenesis_Homo sapiens_hsa049161.03804199
44Oocyte meiosis_Homo sapiens_hsa041141.01870321
45Thyroid cancer_Homo sapiens_hsa052161.00458450
46Tight junction_Homo sapiens_hsa045300.99308166
47Pyrimidine metabolism_Homo sapiens_hsa002400.97835441
48Fatty acid metabolism_Homo sapiens_hsa012120.96185019
49Bladder cancer_Homo sapiens_hsa052190.93802428
50Arginine biosynthesis_Homo sapiens_hsa002200.89143579
51Spliceosome_Homo sapiens_hsa030400.88545468
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85141492
53Proteoglycans in cancer_Homo sapiens_hsa052050.84392393
54Ovarian steroidogenesis_Homo sapiens_hsa049130.82815054
55Fanconi anemia pathway_Homo sapiens_hsa034600.82775669
56Homologous recombination_Homo sapiens_hsa034400.81090636
57Acute myeloid leukemia_Homo sapiens_hsa052210.80853949
58Ras signaling pathway_Homo sapiens_hsa040140.80576025
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79844328
60Axon guidance_Homo sapiens_hsa043600.79810484
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79161257
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78189337
63Asthma_Homo sapiens_hsa053100.77966614
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77824850
65Nucleotide excision repair_Homo sapiens_hsa034200.77067478
66Primary immunodeficiency_Homo sapiens_hsa053400.76323138
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76242407
68Melanoma_Homo sapiens_hsa052180.74672118
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74172773
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.73256962
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.73247446
72Fructose and mannose metabolism_Homo sapiens_hsa000510.72324561
73Pancreatic secretion_Homo sapiens_hsa049720.71050285
74Ribosome_Homo sapiens_hsa030100.70247269
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.70100778
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68693595
77MicroRNAs in cancer_Homo sapiens_hsa052060.67350818
78Glutathione metabolism_Homo sapiens_hsa004800.65497138
79Wnt signaling pathway_Homo sapiens_hsa043100.64051895
80Endometrial cancer_Homo sapiens_hsa052130.63979962
81RNA degradation_Homo sapiens_hsa030180.61837853
82TGF-beta signaling pathway_Homo sapiens_hsa043500.60981872
83ECM-receptor interaction_Homo sapiens_hsa045120.60845648
84Huntingtons disease_Homo sapiens_hsa050160.60468208
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58717377
86Sulfur relay system_Homo sapiens_hsa041220.54496642
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53604450
88Non-homologous end-joining_Homo sapiens_hsa034500.52711082
89beta-Alanine metabolism_Homo sapiens_hsa004100.52159090
90Circadian rhythm_Homo sapiens_hsa047100.52009624
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.51618617
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51147932
93Long-term depression_Homo sapiens_hsa047300.49406777
94Apoptosis_Homo sapiens_hsa042100.49390927
95Biosynthesis of amino acids_Homo sapiens_hsa012300.48798185
96Amoebiasis_Homo sapiens_hsa051460.47255856
97Staphylococcus aureus infection_Homo sapiens_hsa051500.45358349
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43359079
99Glioma_Homo sapiens_hsa052140.43255310
100Dorso-ventral axis formation_Homo sapiens_hsa043200.43239812
101Steroid biosynthesis_Homo sapiens_hsa001000.43203307
102ABC transporters_Homo sapiens_hsa020100.41850792
103GnRH signaling pathway_Homo sapiens_hsa049120.40776133
104PPAR signaling pathway_Homo sapiens_hsa033200.40731212
105Pertussis_Homo sapiens_hsa051330.40069363
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39421416
107HTLV-I infection_Homo sapiens_hsa051660.39398104
108Leishmaniasis_Homo sapiens_hsa051400.39233242
109Tuberculosis_Homo sapiens_hsa051520.38978188
110Rap1 signaling pathway_Homo sapiens_hsa040150.38909059
111Collecting duct acid secretion_Homo sapiens_hsa049660.38822768
112Pathways in cancer_Homo sapiens_hsa052000.38279280
113Chemokine signaling pathway_Homo sapiens_hsa040620.38117975
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.37896963
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36930167
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35839004
117Nitrogen metabolism_Homo sapiens_hsa009100.35309499
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34721945
119Inositol phosphate metabolism_Homo sapiens_hsa005620.33643549
120Metabolic pathways_Homo sapiens_hsa011000.33104952
121Olfactory transduction_Homo sapiens_hsa047400.32933287
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30071294
123Serotonergic synapse_Homo sapiens_hsa047260.29397194
124Prion diseases_Homo sapiens_hsa050200.29388637
125Oxidative phosphorylation_Homo sapiens_hsa001900.29363600
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28994921
127Fatty acid degradation_Homo sapiens_hsa000710.28777337
128Caffeine metabolism_Homo sapiens_hsa002320.28690551
129Galactose metabolism_Homo sapiens_hsa000520.28272390
130Vibrio cholerae infection_Homo sapiens_hsa051100.28185137
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28043090
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27124254
133Glycerolipid metabolism_Homo sapiens_hsa005610.26719393
134Vitamin digestion and absorption_Homo sapiens_hsa049770.24475653
135Chemical carcinogenesis_Homo sapiens_hsa052040.23462730
136Arginine and proline metabolism_Homo sapiens_hsa003300.23390957
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22993228
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22750836
139Selenocompound metabolism_Homo sapiens_hsa004500.21677125
140Amphetamine addiction_Homo sapiens_hsa050310.20939473
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20910222
142Pentose phosphate pathway_Homo sapiens_hsa000300.20624730
143Toxoplasmosis_Homo sapiens_hsa051450.20607999
144MAPK signaling pathway_Homo sapiens_hsa040100.20579345
145Focal adhesion_Homo sapiens_hsa045100.20494209
146Phagosome_Homo sapiens_hsa041450.20336926
147Notch signaling pathway_Homo sapiens_hsa043300.19172894
148Purine metabolism_Homo sapiens_hsa002300.19140923
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19130885
150Mineral absorption_Homo sapiens_hsa049780.18667455
151Fatty acid biosynthesis_Homo sapiens_hsa000610.18370142
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18038069
153Protein digestion and absorption_Homo sapiens_hsa049740.17584586
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.17044805
155Endocytosis_Homo sapiens_hsa041440.16089501
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15669938
157Insulin signaling pathway_Homo sapiens_hsa049100.15207925
158Parkinsons disease_Homo sapiens_hsa050120.15116881
159Pyruvate metabolism_Homo sapiens_hsa006200.14846496
160Steroid hormone biosynthesis_Homo sapiens_hsa001400.14344301

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