PSPC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.33319364
2nuclear pore organization (GO:0006999)5.15465067
3DNA unwinding involved in DNA replication (GO:0006268)5.11814947
4mitotic sister chromatid cohesion (GO:0007064)4.31544204
5pre-miRNA processing (GO:0031054)4.29391295
6protein localization to kinetochore (GO:0034501)4.25981467
7DNA replication-dependent nucleosome organization (GO:0034723)4.12260649
8DNA replication-dependent nucleosome assembly (GO:0006335)4.12260649
9DNA replication initiation (GO:0006270)4.07590617
10protein localization to chromosome, centromeric region (GO:0071459)4.02039990
11mitotic nuclear envelope disassembly (GO:0007077)4.01970948
12kinetochore organization (GO:0051383)3.96233727
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.94923538
14pore complex assembly (GO:0046931)3.93227522
15DNA strand elongation involved in DNA replication (GO:0006271)3.89373199
16regulation of RNA export from nucleus (GO:0046831)3.88771539
17nuclear envelope disassembly (GO:0051081)3.88098304
18membrane disassembly (GO:0030397)3.88098304
19regulation of helicase activity (GO:0051095)3.87909382
20DNA duplex unwinding (GO:0032508)3.83234138
21regulation of histone H3-K9 methylation (GO:0051570)3.80952302
22DNA geometric change (GO:0032392)3.80803490
23mitotic chromosome condensation (GO:0007076)3.77596803
24establishment of integrated proviral latency (GO:0075713)3.75972152
25negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.75768597
26negative regulation of histone methylation (GO:0031061)3.75421895
27spliceosomal tri-snRNP complex assembly (GO:0000244)3.72456933
28sister chromatid segregation (GO:0000819)3.72214183
29DNA strand elongation (GO:0022616)3.66563193
30regulation of sister chromatid cohesion (GO:0007063)3.62179175
31nucleosome disassembly (GO:0006337)3.60976806
32protein-DNA complex disassembly (GO:0032986)3.60976806
33telomere maintenance via semi-conservative replication (GO:0032201)3.56895871
34negative regulation of RNA splicing (GO:0033119)3.54895441
35mitotic sister chromatid segregation (GO:0000070)3.54171370
36IMP biosynthetic process (GO:0006188)3.51169894
37heterochromatin organization (GO:0070828)3.48658952
38chromatin remodeling at centromere (GO:0031055)3.48204933
39mitotic metaphase plate congression (GO:0007080)3.45568943
40mitotic recombination (GO:0006312)3.45519646
41DNA replication-independent nucleosome assembly (GO:0006336)3.42248305
42DNA replication-independent nucleosome organization (GO:0034724)3.42248305
43negative regulation of mRNA processing (GO:0050686)3.39394572
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.37682606
45regulation of gene silencing by RNA (GO:0060966)3.36256303
46regulation of posttranscriptional gene silencing (GO:0060147)3.36256303
47regulation of gene silencing by miRNA (GO:0060964)3.36256303
48kinetochore assembly (GO:0051382)3.35995051
49telomere maintenance via recombination (GO:0000722)3.32994897
50chromatin assembly or disassembly (GO:0006333)3.32830673
51translesion synthesis (GO:0019985)3.31699901
52histone H2B ubiquitination (GO:0033523)3.31239230
53CENP-A containing nucleosome assembly (GO:0034080)3.30787869
54folic acid-containing compound biosynthetic process (GO:0009396)3.30444576
55regulation of centriole replication (GO:0046599)3.29676412
56formation of translation preinitiation complex (GO:0001731)3.27076668
57histone exchange (GO:0043486)3.26200243
58attachment of spindle microtubules to kinetochore (GO:0008608)3.23527949
59positive regulation of chromosome segregation (GO:0051984)3.22603515
60DNA replication checkpoint (GO:0000076)3.22550748
61termination of RNA polymerase II transcription (GO:0006369)3.19825023
62regulation of chromosome segregation (GO:0051983)3.19680489
63metaphase plate congression (GO:0051310)3.19610711
64negative regulation of chromosome segregation (GO:0051985)3.19465063
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18257774
66negative regulation of mRNA metabolic process (GO:1903312)3.17843609
67ATP-dependent chromatin remodeling (GO:0043044)3.17017969
68regulation of retinoic acid receptor signaling pathway (GO:0048385)3.16611522
69V(D)J recombination (GO:0033151)3.16491123
70regulation of centrosome cycle (GO:0046605)3.15761289
71alternative mRNA splicing, via spliceosome (GO:0000380)3.15591863
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14823469
73negative regulation of sister chromatid segregation (GO:0033046)3.14823469
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.14823469
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14823469
76spindle assembly checkpoint (GO:0071173)3.14464114
77RNA splicing, via transesterification reactions (GO:0000375)3.12552997
78protein complex localization (GO:0031503)3.12225264
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11727120
80positive regulation of mitotic sister chromatid separation (GO:1901970)3.11727120
81positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11727120
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11250013
83dosage compensation (GO:0007549)3.10903080
84DNA conformation change (GO:0071103)3.10470843
85mitotic spindle assembly checkpoint (GO:0007094)3.09682618
86regulation of nucleobase-containing compound transport (GO:0032239)3.06643202
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.05354358
88ribosome assembly (GO:0042255)3.04999146
89chromatin assembly (GO:0031497)3.04723639
90regulation of spindle organization (GO:0090224)3.03644996
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02928182
92histone H2A acetylation (GO:0043968)3.02820511
93regulation of mitotic sister chromatid separation (GO:0010965)3.02767394
94regulation of mitotic sister chromatid segregation (GO:0033047)3.02767394
95regulation of sister chromatid segregation (GO:0033045)3.02767394
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02139415
97spindle checkpoint (GO:0031577)3.01902508
98RNA stabilization (GO:0043489)3.01826735
99mRNA stabilization (GO:0048255)3.01826735
100DNA topological change (GO:0006265)3.01196458
101IMP metabolic process (GO:0046040)2.99251617
102nuclear envelope organization (GO:0006998)2.98837501
103histone arginine methylation (GO:0034969)2.98555669
104regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98281600
105histone H3-K36 demethylation (GO:0070544)2.98022932
106mitotic spindle checkpoint (GO:0071174)2.96766037
107peptidyl-lysine dimethylation (GO:0018027)2.95468098
108protein localization to chromosome (GO:0034502)2.94943951
109regulation of translational fidelity (GO:0006450)2.94885858
110nucleobase biosynthetic process (GO:0046112)2.94841765
111telomere maintenance via telomere lengthening (GO:0010833)2.94546401
112peptidyl-arginine omega-N-methylation (GO:0035247)2.94124497
113regulation of NFAT protein import into nucleus (GO:0051532)2.93023130
114ribosome biogenesis (GO:0042254)2.92988171
115somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92416794
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.92416794
117DNA synthesis involved in DNA repair (GO:0000731)2.91966754
118mRNA splice site selection (GO:0006376)2.91605877
119RNA export from nucleus (GO:0006405)2.90286348
120regulation of mRNA stability (GO:0043488)2.90263603
121mRNA splicing, via spliceosome (GO:0000398)2.88576557
122RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.88576557
123mRNA transport (GO:0051028)2.88492754
124maturation of SSU-rRNA (GO:0030490)2.87903944
125mRNA export from nucleus (GO:0006406)2.87250125
126ribosomal small subunit biogenesis (GO:0042274)2.82566930
127establishment of viral latency (GO:0019043)2.82023562
128chromosome condensation (GO:0030261)2.81831260
129peptidyl-arginine methylation (GO:0018216)2.80015855
130peptidyl-arginine N-methylation (GO:0035246)2.80015855
131regulation of mRNA splicing, via spliceosome (GO:0048024)2.79322861
132DNA damage induced protein phosphorylation (GO:0006975)2.77621359
133nucleic acid transport (GO:0050657)2.75477912
134RNA transport (GO:0050658)2.75477912
135establishment of RNA localization (GO:0051236)2.75477912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.54853971
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.40046878
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.87023085
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.37462190
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20736574
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99702023
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90869278
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.73137471
9* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64832950
10MYC_22102868_ChIP-Seq_BL_Human2.63923912
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52070817
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.40837470
13AR_21909140_ChIP-Seq_LNCAP_Human2.32054808
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24163464
15XRN2_22483619_ChIP-Seq_HELA_Human2.12388240
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09547410
17E2F7_22180533_ChIP-Seq_HELA_Human10.7824233
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.97618212
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95383789
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93802904
21* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89414169
22CIITA_25753668_ChIP-Seq_RAJI_Human1.85084166
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84782358
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76990431
25* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73000201
26TTF2_22483619_ChIP-Seq_HELA_Human1.66369477
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64239167
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.61045394
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.60398354
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59396458
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57454370
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56845371
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.56576929
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54535637
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54267174
36* VDR_23849224_ChIP-Seq_CD4+_Human1.53650838
37* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52482321
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50534768
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49912870
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49384606
41* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49140805
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44547475
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43209896
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40341064
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39542419
46VDR_21846776_ChIP-Seq_THP-1_Human1.39320207
47KDM5A_27292631_Chip-Seq_BREAST_Human1.38340326
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.38334885
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37378579
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36641318
51* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36569541
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36353920
53* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34199455
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33766106
55FOXP3_21729870_ChIP-Seq_TREG_Human1.32895994
56GABP_19822575_ChIP-Seq_HepG2_Human1.31987817
57* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31582375
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.30269992
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29313820
60DCP1A_22483619_ChIP-Seq_HELA_Human1.27512954
61ZNF263_19887448_ChIP-Seq_K562_Human1.26902813
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23589913
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23332964
64SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.22230026
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20773628
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20104815
67* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20080219
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19525299
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18540508
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15960998
71IRF1_19129219_ChIP-ChIP_H3396_Human1.14937798
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13532740
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12939920
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.12095923
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10347338
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.08387968
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08383127
78PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07124146
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05445899
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05275717
81TCF7_22412390_ChIP-Seq_EML_Mouse1.05130810
82ELK1_19687146_ChIP-ChIP_HELA_Human1.05041725
83JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04758401
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03839776
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03563034
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03383806
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01535177
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01535177
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01535177
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00751729
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00579235
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00250283
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99675208
94GABP_17652178_ChIP-ChIP_JURKAT_Human0.99083917
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97438963
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96707573
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96403280
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94971283
99ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94842148
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94745507
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93941867
102TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93558030
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93505635
104TFEB_21752829_ChIP-Seq_HELA_Human0.93488118
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93150101
106KDM2B_26808549_Chip-Seq_DND41_Human0.93097697
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93014850
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92795933
109* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92320111
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91457846
111CHD1_26751641_Chip-Seq_LNCaP_Human0.89929271
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89883379
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89472133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.13991688
2MP0003111_abnormal_nucleus_morphology3.98071428
3MP0003693_abnormal_embryo_hatching3.69456187
4MP0008057_abnormal_DNA_replication3.61979709
5MP0004957_abnormal_blastocyst_morpholog3.49700974
6MP0003077_abnormal_cell_cycle3.46751315
7MP0003123_paternal_imprinting2.77175017
8MP0010352_gastrointestinal_tract_polyps2.75858355
9MP0008058_abnormal_DNA_repair2.61532093
10MP0008877_abnormal_DNA_methylation2.56102976
11MP0005076_abnormal_cell_differentiation2.49707465
12MP0008007_abnormal_cellular_replicative2.39868795
13MP0001730_embryonic_growth_arrest2.37768002
14MP0000350_abnormal_cell_proliferation2.35653221
15MP0010307_abnormal_tumor_latency2.23858908
16MP0003121_genomic_imprinting2.23292866
17MP0000569_abnormal_digit_pigmentation2.07264480
18MP0008932_abnormal_embryonic_tissue2.04508055
19MP0002084_abnormal_developmental_patter1.97167240
20MP0005380_embryogenesis_phenotype1.92030461
21MP0001672_abnormal_embryogenesis/_devel1.92030461
22MP0000537_abnormal_urethra_morphology1.91570862
23MP0004185_abnormal_adipocyte_glucose1.88030120
24MP0004197_abnormal_fetal_growth/weight/1.87494549
25MP0005451_abnormal_body_composition1.86061475
26MP0003221_abnormal_cardiomyocyte_apopto1.85796599
27MP0001697_abnormal_embryo_size1.85733147
28MP0002085_abnormal_embryonic_tissue1.84573494
29MP0003890_abnormal_embryonic-extraembry1.80182877
30MP0002396_abnormal_hematopoietic_system1.79171460
31MP0003984_embryonic_growth_retardation1.75410297
32MP0002088_abnormal_embryonic_growth/wei1.72922521
33MP0010030_abnormal_orbit_morphology1.69363627
34MP0003567_abnormal_fetal_cardiomyocyte1.64681805
35MP0008260_abnormal_autophagy1.62188546
36MP0002080_prenatal_lethality1.62020466
37MP0001293_anophthalmia1.58561989
38MP0002086_abnormal_extraembryonic_tissu1.57949507
39MP0002653_abnormal_ependyma_morphology1.57755264
40MP0004808_abnormal_hematopoietic_stem1.57716291
41MP0002254_reproductive_system_inflammat1.54624404
42MP0003787_abnormal_imprinting1.48957571
43MP0003119_abnormal_digestive_system1.48110502
44MP0005394_taste/olfaction_phenotype1.38520274
45MP0005499_abnormal_olfactory_system1.38520274
46MP0003283_abnormal_digestive_organ1.36559755
47MP0000490_abnormal_crypts_of1.33640522
48MP0000313_abnormal_cell_death1.32862799
49MP0002210_abnormal_sex_determination1.30328937
50MP0003705_abnormal_hypodermis_morpholog1.24308274
51MP0009672_abnormal_birth_weight1.22260348
52MP0002877_abnormal_melanocyte_morpholog1.21799625
53MP0008789_abnormal_olfactory_epithelium1.18411329
54MP0004264_abnormal_extraembryonic_tissu1.18271037
55MP0000428_abnormal_craniofacial_morphol1.17275158
56MP0009703_decreased_birth_body1.16932307
57MP0003861_abnormal_nervous_system1.16013300
58MP0001145_abnormal_male_reproductive1.14555777
59MP0006035_abnormal_mitochondrial_morpho1.14138567
60MP0009053_abnormal_anal_canal1.11699840
61MP0003115_abnormal_respiratory_system1.10986154
62MP0001929_abnormal_gametogenesis1.10887377
63MP0003786_premature_aging1.10586124
64MP0010234_abnormal_vibrissa_follicle1.09481637
65MP0002019_abnormal_tumor_incidence1.08123143
66MP0003315_abnormal_perineum_morphology1.07554836
67MP0005501_abnormal_skin_physiology1.06786703
68MP0003937_abnormal_limbs/digits/tail_de1.05858784
69MP0000703_abnormal_thymus_morphology1.04497870
70MP0002092_abnormal_eye_morphology1.01313880
71MP0003941_abnormal_skin_development1.00509376
72MP0000733_abnormal_muscle_development0.99867004
73MP0003935_abnormal_craniofacial_develop0.97594161
74MP0003303_peritoneal_inflammation0.96446044
75MP0009278_abnormal_bone_marrow0.96428643
76MP0001727_abnormal_embryo_implantation0.96089890
77MP0003718_maternal_effect0.95867576
78MP0004133_heterotaxia0.94447195
79MP0005397_hematopoietic_system_phenotyp0.93470647
80MP0001545_abnormal_hematopoietic_system0.93470647
81MP0002111_abnormal_tail_morphology0.93313817
82MP0003122_maternal_imprinting0.93298810
83MP0002796_impaired_skin_barrier0.92319412
84MP0004233_abnormal_muscle_weight0.92056998
85MP0001849_ear_inflammation0.91663911
86MP0000653_abnormal_sex_gland0.91641216
87MP0006292_abnormal_olfactory_placode0.91420742
88MP0001915_intracranial_hemorrhage0.88941927
89MP0002697_abnormal_eye_size0.86125265
90MP0002925_abnormal_cardiovascular_devel0.85688145
91MP0001529_abnormal_vocalization0.84868067
92MP0002089_abnormal_postnatal_growth/wei0.82553539
93MP0002160_abnormal_reproductive_system0.82285448
94MP0000432_abnormal_head_morphology0.81844210
95MP0008770_decreased_survivor_rate0.81658963
96MP0003698_abnormal_male_reproductive0.81140069
97MP0001919_abnormal_reproductive_system0.80765650
98MP0001188_hyperpigmentation0.78519127
99MP0003385_abnormal_body_wall0.77778576
100MP0002081_perinatal_lethality0.76270191
101MP0005384_cellular_phenotype0.75893233
102MP0000689_abnormal_spleen_morphology0.75703988
103MP0000358_abnormal_cell_content/0.74589497
104MP0005187_abnormal_penis_morphology0.73093537
105MP0003763_abnormal_thymus_physiology0.72581267
106MP0008995_early_reproductive_senescence0.72396590
107MP0001286_abnormal_eye_development0.71816206
108MP0008961_abnormal_basal_metabolism0.71418985
109MP0002282_abnormal_trachea_morphology0.71338503
110MP0004811_abnormal_neuron_physiology0.70888240
111MP0005621_abnormal_cell_physiology0.70658817
112MP0006054_spinal_hemorrhage0.69359725
113MP0002116_abnormal_craniofacial_bone0.68729089
114MP0002114_abnormal_axial_skeleton0.68237513
115MP0002398_abnormal_bone_marrow0.67896618
116MP0002429_abnormal_blood_cell0.67756269
117MP0002166_altered_tumor_susceptibility0.67319267
118MP0005310_abnormal_salivary_gland0.66980823
119MP0003755_abnormal_palate_morphology0.66977879
120MP0002006_tumorigenesis0.66412452
121MP0000266_abnormal_heart_morphology0.65267494
122MP0000716_abnormal_immune_system0.62358701
123MP0002233_abnormal_nose_morphology0.62177756
124MP0002163_abnormal_gland_morphology0.61857416
125MP0000778_abnormal_nervous_system0.61643032
126MP0002075_abnormal_coat/hair_pigmentati0.61311105
127MP0000477_abnormal_intestine_morphology0.60851113
128MP0002932_abnormal_joint_morphology0.60346566
129MP0002009_preneoplasia0.60307542
130MP0002161_abnormal_fertility/fecundity0.59907711
131MP0010630_abnormal_cardiac_muscle0.57458172
132MP0002751_abnormal_autonomic_nervous0.57237805
133MP0002722_abnormal_immune_system0.56826309

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.99713483
2Medulloblastoma (HP:0002885)3.74904907
3Colon cancer (HP:0003003)3.50428311
4Abnormality of the astrocytes (HP:0100707)3.36067569
5Astrocytoma (HP:0009592)3.36067569
6Birth length less than 3rd percentile (HP:0003561)3.29279815
7Cortical dysplasia (HP:0002539)3.15989530
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.10249691
9Short 4th metacarpal (HP:0010044)3.10249691
10Increased nuchal translucency (HP:0010880)3.09374693
11Papillary thyroid carcinoma (HP:0002895)3.09127667
12Glioma (HP:0009733)3.05308346
13Volvulus (HP:0002580)3.04140441
14Progressive external ophthalmoplegia (HP:0000590)2.99773396
15Multiple enchondromatosis (HP:0005701)2.95363484
16Progressive muscle weakness (HP:0003323)2.93121761
17Selective tooth agenesis (HP:0001592)2.86989222
18Abnormality of the labia minora (HP:0012880)2.85371413
19Abnormal number of incisors (HP:0011064)2.78091652
20Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.72394147
21Nephroblastoma (Wilms tumor) (HP:0002667)2.70057717
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.66955453
23Rhabdomyosarcoma (HP:0002859)2.65344118
24Syringomyelia (HP:0003396)2.64242068
25Spinal cord lesions (HP:0100561)2.64242068
26Microvesicular hepatic steatosis (HP:0001414)2.63455341
27Basal cell carcinoma (HP:0002671)2.58738744
28Neoplasm of the oral cavity (HP:0100649)2.56130825
29Shoulder girdle muscle weakness (HP:0003547)2.52398105
30Neoplasm of striated muscle (HP:0009728)2.49160957
31Proximal placement of thumb (HP:0009623)2.47002378
32Trigonocephaly (HP:0000243)2.46873329
33Agnosia (HP:0010524)2.45809199
34Degeneration of anterior horn cells (HP:0002398)2.45495174
35Abnormality of the anterior horn cell (HP:0006802)2.45495174
36Embryonal renal neoplasm (HP:0011794)2.45372955
37Deviation of the thumb (HP:0009603)2.38977166
38Long eyelashes (HP:0000527)2.37628554
39Facial cleft (HP:0002006)2.36699015
40Hyperacusis (HP:0010780)2.36167002
41Hepatoblastoma (HP:0002884)2.34761863
42Heterotopia (HP:0002282)2.33856252
43Patellar aplasia (HP:0006443)2.32833214
44B lymphocytopenia (HP:0010976)2.32177308
45Prominent nose (HP:0000448)2.31182172
46Renal duplication (HP:0000075)2.30786065
47IgA deficiency (HP:0002720)2.29896275
48Abnormality of the lower motor neuron (HP:0002366)2.25588313
49Abnormality of chromosome stability (HP:0003220)2.21656468
50T lymphocytopenia (HP:0005403)2.21422645
51Deep philtrum (HP:0002002)2.21197419
52Abnormality of the hip-girdle musculature (HP:0001445)2.21183949
53Abnormality of the musculature of the pelvis (HP:0001469)2.21183949
54Combined immunodeficiency (HP:0005387)2.20456455
55Hypoplasia of the thymus (HP:0000778)2.19562493
56Impulsivity (HP:0100710)2.17641705
57Thyroid carcinoma (HP:0002890)2.16039500
58Aplasia/Hypoplasia of the patella (HP:0006498)2.15403724
59Supernumerary spleens (HP:0009799)2.14281512
60Gastrointestinal carcinoma (HP:0002672)2.13387296
61Malignant gastrointestinal tract tumors (HP:0006749)2.13387296
62Chromsome breakage (HP:0040012)2.12798336
63Abnormality of the 4th metacarpal (HP:0010012)2.12220379
64Breast hypoplasia (HP:0003187)2.11466103
65Abnormality of the fingertips (HP:0001211)2.11429101
66Renovascular hypertension (HP:0100817)2.10465623
67Ectopic kidney (HP:0000086)2.07495901
68Overriding aorta (HP:0002623)2.06223490
69Leiomyosarcoma (HP:0100243)2.06112043
70Uterine leiomyosarcoma (HP:0002891)2.06112043
71Aplasia/Hypoplasia of the sternum (HP:0006714)2.05394712
72Aplasia involving forearm bones (HP:0009822)2.03759747
73Absent forearm bone (HP:0003953)2.03759747
74Missing ribs (HP:0000921)2.01537549
75Atrophy/Degeneration involving motor neurons (HP:0007373)2.01437745
76Cleft eyelid (HP:0000625)2.01116470
77Overlapping toe (HP:0001845)2.00494401
78Biliary tract neoplasm (HP:0100574)1.99271110
79Atresia of the external auditory canal (HP:0000413)1.98234698
80Amyotrophic lateral sclerosis (HP:0007354)1.97450545
81Partial agenesis of the corpus callosum (HP:0001338)1.96271771
82Elfin facies (HP:0004428)1.95690940
83Insomnia (HP:0100785)1.94891678
84Broad palm (HP:0001169)1.94760354
85Reticulocytopenia (HP:0001896)1.94094393
86Deep palmar crease (HP:0006191)1.92615218
87Supernumerary ribs (HP:0005815)1.92092773
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.91738742
89Premature ovarian failure (HP:0008209)1.91703458
90Dysphonia (HP:0001618)1.91531109
91Abdominal situs inversus (HP:0003363)1.91464986
92Abnormality of abdominal situs (HP:0011620)1.91464986
93Ragged-red muscle fibers (HP:0003200)1.91452426
94Transitional cell carcinoma of the bladder (HP:0006740)1.91367606
95Pointed chin (HP:0000307)1.90813835
96Cafe-au-lait spot (HP:0000957)1.90521279
97Sandal gap (HP:0001852)1.89680370
98Abnormality of the preputium (HP:0100587)1.89410616
99Fibular aplasia (HP:0002990)1.89205541
100Obsessive-compulsive behavior (HP:0000722)1.89115229
101Neoplasm of the pancreas (HP:0002894)1.89113261
102Horseshoe kidney (HP:0000085)1.88269554
103Urinary urgency (HP:0000012)1.88125502
104Cellular immunodeficiency (HP:0005374)1.87808024
105Severe combined immunodeficiency (HP:0004430)1.87731811
106Abnormality of the septum pellucidum (HP:0007375)1.86878031
107Embryonal neoplasm (HP:0002898)1.86869954
108Small intestinal stenosis (HP:0012848)1.86692516
109Duodenal stenosis (HP:0100867)1.86692516
110Abnormality of the carotid arteries (HP:0005344)1.85245164
111Acute myeloid leukemia (HP:0004808)1.85228707
112Termporal pattern (HP:0011008)1.84622740
113Insidious onset (HP:0003587)1.84622740
114High anterior hairline (HP:0009890)1.84320761
115Absent thumb (HP:0009777)1.84257949
116Facial hemangioma (HP:0000329)1.84115992
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83364481
118Meckel diverticulum (HP:0002245)1.81765238
119High pitched voice (HP:0001620)1.81310216
120Broad thumb (HP:0011304)1.81011461
121Abnormality of the aortic arch (HP:0012303)1.80965608
122Intestinal polyp (HP:0005266)1.80792152
123Pseudobulbar signs (HP:0002200)1.80689290
124Abnormality of the phalanges of the hallux (HP:0010057)1.79842707
125Supernumerary bones of the axial skeleton (HP:0009144)1.79751930
126Megalocornea (HP:0000485)1.79410499
127Skin tags (HP:0010609)1.79310881
12811 pairs of ribs (HP:0000878)1.79253937
129Sparse lateral eyebrow (HP:0005338)1.79133124
130Skull defect (HP:0001362)1.78873592
131Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78293091
132Intestinal polyposis (HP:0200008)1.77363082
133Myelodysplasia (HP:0002863)1.76823936
134Abnormality of the ileum (HP:0001549)1.76400085
135Neoplasm of the adrenal cortex (HP:0100641)1.75621103
136Sacral dimple (HP:0000960)1.75326547
137Tracheoesophageal fistula (HP:0002575)1.75087676
138Panhypogammaglobulinemia (HP:0003139)1.75045126
139Personality changes (HP:0000751)1.74529477
140Bowel diverticulosis (HP:0005222)1.74167020
141Pelvic girdle muscle weakness (HP:0003749)1.73655253
142Broad phalanges of the hand (HP:0009768)1.72844587
143Abnormality of the columella (HP:0009929)1.72800668
144Neoplasm of the colon (HP:0100273)1.71694323
145Viral hepatitis (HP:0006562)1.71536075
146Abnormality of B cell number (HP:0010975)1.71415213
147Abnormality of the diencephalon (HP:0010662)1.70801152
148Spinal muscular atrophy (HP:0007269)1.70481670
149Curly hair (HP:0002212)1.70304181
150Neoplasm of the small intestine (HP:0100833)1.70027328
151Cutis marmorata (HP:0000965)1.69392530
152IgM deficiency (HP:0002850)1.68924790
153Acute lymphatic leukemia (HP:0006721)1.68790000
154Bladder neoplasm (HP:0009725)1.68616758
155Bladder carcinoma (HP:0002862)1.68616758
156Truncal obesity (HP:0001956)1.68260393
157Breast carcinoma (HP:0003002)1.68164530
158Abnormality of chromosome segregation (HP:0002916)1.67364967
159Short phalanx of the thumb (HP:0009660)1.66867139
160Carpal bone hypoplasia (HP:0001498)1.66851829
161Absent radius (HP:0003974)1.66617648
162Low anterior hairline (HP:0000294)1.66043276
163Large earlobe (HP:0009748)1.65796124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.31768771
2CDK123.66915666
3NEK23.54588863
4WEE13.20213156
5BUB12.91806838
6ACVR1B2.52323648
7TAOK22.47457670
8PBK2.44457556
9SMG12.37092647
10MAP3K102.36203860
11SCYL22.30077712
12SRPK12.27704212
13MKNK12.27099113
14EEF2K2.22600154
15NEK12.08558480
16ATR1.90224421
17MAP2K71.89393214
18TLK11.87710885
19PASK1.86644340
20TTK1.84467277
21CDK71.74413096
22RPS6KB21.74225977
23TSSK61.68932925
24PLK11.68069115
25CDK41.62628234
26BRD41.61575123
27MKNK21.54791840
28TGFBR11.53017516
29TESK21.51846419
30CDK191.49349370
31DYRK31.49153824
32PLK31.48113161
33ALK1.48035175
34PKN21.45685888
35CHEK21.45188137
36CHEK11.44191022
37AURKB1.43260773
38CDK61.39766483
39ICK1.33272516
40EIF2AK11.31430701
41PNCK1.26475720
42RPS6KA41.20461330
43BRSK21.18502570
44MAP3K51.17696218
45ATM1.14731377
46MAP3K141.12839871
47CDK21.12541936
48NME21.06496974
49VRK11.04771815
50BRSK11.03860095
51PAK41.03592824
52MTOR1.01822278
53MAP3K81.01165593
54KSR10.97811916
55TAF10.95127954
56AURKA0.87493475
57CAMK1D0.86497586
58CDK10.86238705
59STK100.86151629
60MAP2K20.84476141
61PLK40.81956066
62TYRO30.78723008
63PRPF4B0.78639924
64CSNK1A1L0.76863313
65BCR0.75323952
66FGFR10.73934370
67DYRK1B0.72683071
68SIK20.72055815
69CDK30.71253549
70CSNK1G30.69970468
71MARK10.67404509
72RPS6KB10.66720841
73PRKDC0.65377579
74TAOK10.64691342
75PAK20.64660064
76CAMK1G0.63963644
77MELK0.63126090
78MATK0.62934677
79CDK90.61872931
80CSNK1E0.61249198
81CSNK1G20.59596911
82CSNK1D0.57350224
83LATS20.57156136
84RPS6KA10.57146774
85DYRK20.56766697
86PDGFRA0.55955224
87CSNK2A20.55922711
88ERBB30.55729245
89MAP3K90.55052972
90CSNK1G10.54613950
91MAPK140.53862452
92DMPK0.52960944
93TNIK0.52647340
94EIF2AK20.52415664
95STK38L0.52412151
96STK40.52251216
97LATS10.47644215
98MAP3K40.45699053
99HIPK20.44911749
100FGFR40.44490606
101DDR20.43508187
102AKT20.43383773
103GSK3B0.43357636
104RPS6KL10.41662261
105RPS6KC10.41662261
106STK30.41568394
107PIM10.41420264
108MAP4K10.41289710
109LRRK20.39867249
110BRAF0.39618472
111CDK11A0.39364750
112MARK20.39035350
113MAPK100.38423999
114MAPK90.37892791
115TRIB30.37706318
116ERBB20.37131167
117RIPK10.36990441
118IRAK20.35864430
119TESK10.34443831
120CCNB10.34427189
121RPS6KA50.33999844
122CDK150.33939008
123CDK180.33701773
124CSNK2A10.32504106
125PDK30.32388637
126PDK40.32388637
127CLK10.32104186
128CDK140.32008691
129MAPK10.31741043
130AKT10.31618077
131ZAK0.31117056
132MAPK80.30240855

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.32312637
2Mismatch repair_Homo sapiens_hsa034303.67594455
3Spliceosome_Homo sapiens_hsa030403.22889404
4RNA transport_Homo sapiens_hsa030132.96589373
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92770986
6Cell cycle_Homo sapiens_hsa041102.82315214
7Base excision repair_Homo sapiens_hsa034102.45864867
8Nucleotide excision repair_Homo sapiens_hsa034202.29692575
9Homologous recombination_Homo sapiens_hsa034402.26724427
10mRNA surveillance pathway_Homo sapiens_hsa030152.18841139
11One carbon pool by folate_Homo sapiens_hsa006702.11348545
12Fanconi anemia pathway_Homo sapiens_hsa034601.97171737
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94427608
14Oocyte meiosis_Homo sapiens_hsa041141.66293915
15RNA degradation_Homo sapiens_hsa030181.65827790
16Systemic lupus erythematosus_Homo sapiens_hsa053221.65042620
17Non-homologous end-joining_Homo sapiens_hsa034501.62182169
18Ribosome_Homo sapiens_hsa030101.49608319
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48701378
20p53 signaling pathway_Homo sapiens_hsa041151.47805878
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.44920464
22RNA polymerase_Homo sapiens_hsa030201.43638272
23Basal transcription factors_Homo sapiens_hsa030221.34164708
24Viral carcinogenesis_Homo sapiens_hsa052031.33806015
25MicroRNAs in cancer_Homo sapiens_hsa052061.31371528
26Pyrimidine metabolism_Homo sapiens_hsa002401.28808086
27Basal cell carcinoma_Homo sapiens_hsa052171.27631191
28Colorectal cancer_Homo sapiens_hsa052101.25827525
29HTLV-I infection_Homo sapiens_hsa051661.25246180
30mTOR signaling pathway_Homo sapiens_hsa041501.16351871
31Alcoholism_Homo sapiens_hsa050341.16204722
32Epstein-Barr virus infection_Homo sapiens_hsa051691.12045416
33Chronic myeloid leukemia_Homo sapiens_hsa052201.07849338
34Hippo signaling pathway_Homo sapiens_hsa043901.06582015
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03771936
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03136213
37Hedgehog signaling pathway_Homo sapiens_hsa043401.00487378
38Small cell lung cancer_Homo sapiens_hsa052220.95981211
39Herpes simplex infection_Homo sapiens_hsa051680.93664433
40Adherens junction_Homo sapiens_hsa045200.92713605
41Thyroid cancer_Homo sapiens_hsa052160.91317233
42Proteasome_Homo sapiens_hsa030500.91085436
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90532702
44Notch signaling pathway_Homo sapiens_hsa043300.90450683
45Antigen processing and presentation_Homo sapiens_hsa046120.88830989
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.88064707
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87488214
48Wnt signaling pathway_Homo sapiens_hsa043100.85856094
49Measles_Homo sapiens_hsa051620.84402346
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.84207862
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80946570
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78355107
53Endometrial cancer_Homo sapiens_hsa052130.77085259
54TGF-beta signaling pathway_Homo sapiens_hsa043500.75994278
55Viral myocarditis_Homo sapiens_hsa054160.75243052
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74570449
57Non-small cell lung cancer_Homo sapiens_hsa052230.74067106
58Prolactin signaling pathway_Homo sapiens_hsa049170.73777124
59Hepatitis B_Homo sapiens_hsa051610.73493469
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73133123
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.70782768
62Glioma_Homo sapiens_hsa052140.68683234
63Steroid biosynthesis_Homo sapiens_hsa001000.68520204
64Bladder cancer_Homo sapiens_hsa052190.67515048
65Hepatitis C_Homo sapiens_hsa051600.66502521
66Proteoglycans in cancer_Homo sapiens_hsa052050.65319146
67Purine metabolism_Homo sapiens_hsa002300.65104134
68Pathways in cancer_Homo sapiens_hsa052000.64507148
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62867550
70Lysine degradation_Homo sapiens_hsa003100.62663868
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62586261
72Inositol phosphate metabolism_Homo sapiens_hsa005620.62398470
73Acute myeloid leukemia_Homo sapiens_hsa052210.61211755
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59769493
75VEGF signaling pathway_Homo sapiens_hsa043700.59133690
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58432078
77HIF-1 signaling pathway_Homo sapiens_hsa040660.58385934
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57491189
79Pancreatic cancer_Homo sapiens_hsa052120.57171995
80Prostate cancer_Homo sapiens_hsa052150.56193950
81T cell receptor signaling pathway_Homo sapiens_hsa046600.54716431
82Apoptosis_Homo sapiens_hsa042100.54017727
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53361142
84Renal cell carcinoma_Homo sapiens_hsa052110.52738159
85B cell receptor signaling pathway_Homo sapiens_hsa046620.52680301
86Salmonella infection_Homo sapiens_hsa051320.51310934
87Shigellosis_Homo sapiens_hsa051310.50573082
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50132030
89Dorso-ventral axis formation_Homo sapiens_hsa043200.50079647
90Biosynthesis of amino acids_Homo sapiens_hsa012300.49308043
91TNF signaling pathway_Homo sapiens_hsa046680.48015713
92Estrogen signaling pathway_Homo sapiens_hsa049150.47928612
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.47469911
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.46821737
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46658086
96ErbB signaling pathway_Homo sapiens_hsa040120.46035892
97Pentose phosphate pathway_Homo sapiens_hsa000300.44514055
98Tight junction_Homo sapiens_hsa045300.43200031
99Choline metabolism in cancer_Homo sapiens_hsa052310.41509172
100Melanoma_Homo sapiens_hsa052180.41357039
101Melanogenesis_Homo sapiens_hsa049160.41056388
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40166965
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39167438
104Focal adhesion_Homo sapiens_hsa045100.38283865
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38192370
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37962773
107Long-term potentiation_Homo sapiens_hsa047200.37931671
108MAPK signaling pathway_Homo sapiens_hsa040100.37834085
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37570954
110Selenocompound metabolism_Homo sapiens_hsa004500.35992622
111FoxO signaling pathway_Homo sapiens_hsa040680.35905928
112Axon guidance_Homo sapiens_hsa043600.34719466
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34442412
114Gap junction_Homo sapiens_hsa045400.34332855
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33936281
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.33792247
117Legionellosis_Homo sapiens_hsa051340.32213533
118Influenza A_Homo sapiens_hsa051640.31530937
119Insulin signaling pathway_Homo sapiens_hsa049100.31040150
120Rap1 signaling pathway_Homo sapiens_hsa040150.29676077
121AMPK signaling pathway_Homo sapiens_hsa041520.29471299
122Primary immunodeficiency_Homo sapiens_hsa053400.28484709

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