ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial DNA replication (GO:0006264)	6.59679491
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.28993026
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.09625434
4	ribosomal small subunit biogenesis (GO:0042274)	5.07357065
5	viral transcription (GO:0019083)	5.07040814
6	translational termination (GO:0006415)	4.88716066
7	kinetochore assembly (GO:0051382)	4.82216823
8	ATP synthesis coupled proton transport (GO:0015986)	4.71882134
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.71882134
10	DNA-dependent DNA replication (GO:0006261)	4.52710739
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.41295064
12	cotranslational protein targeting to membrane (GO:0006613)	4.35281209
13	protein targeting to ER (GO:0045047)	4.31597556
14	chaperone-mediated protein transport (GO:0072321)	4.28260088
15	maturation of SSU-rRNA (GO:0030490)	4.22452325
16	cell wall macromolecule catabolic process (GO:0016998)	4.21047142
17	mitochondrial DNA metabolic process (GO:0032042)	4.13635444
18	protein localization to endoplasmic reticulum (GO:0070972)	4.06716242
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.06065730
20	translational elongation (GO:0006414)	4.03188162
21	ribosomal large subunit biogenesis (GO:0042273)	4.00966896
22	rRNA modification (GO:0000154)	3.99622887
23	kinetochore organization (GO:0051383)	3.96855879
24	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.94609661
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.89653277
26	protein complex biogenesis (GO:0070271)	3.71218944
27	cell wall macromolecule metabolic process (GO:0044036)	3.67650753
28	cellular protein complex disassembly (GO:0043624)	3.67057578
29	GTP biosynthetic process (GO:0006183)	3.66991447
30	response to pheromone (GO:0019236)	3.58984363
31	ribosomal small subunit assembly (GO:0000028)	3.57931259
32	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.54991399
33	chromatin remodeling at centromere (GO:0031055)	3.53414987
34	viral life cycle (GO:0019058)	3.52313750
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.52114747
36	respiratory electron transport chain (GO:0022904)	3.48417065
37	electron transport chain (GO:0022900)	3.46063525
38	sperm motility (GO:0030317)	3.41170158
39	CENP-A containing nucleosome assembly (GO:0034080)	3.36674277
40	T cell apoptotic process (GO:0070231)	3.35349806
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.34727800
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.34727800
43	NADH dehydrogenase complex assembly (GO:0010257)	3.34727800
44	translational initiation (GO:0006413)	3.34670250
45	single strand break repair (GO:0000012)	3.31654412
46	termination of RNA polymerase III transcription (GO:0006386)	3.31280893
47	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.31280893
48	histone exchange (GO:0043486)	3.27508251
49	protein neddylation (GO:0045116)	3.26648729
50	resolution of meiotic recombination intermediates (GO:0000712)	3.22216396
51	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.16043410
52	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.16043410
53	protein complex disassembly (GO:0043241)	3.15101746
54	translation (GO:0006412)	3.14073773
55	positive regulation of catecholamine secretion (GO:0033605)	3.08816261
56	T cell lineage commitment (GO:0002360)	3.05572721
57	lymphocyte apoptotic process (GO:0070227)	3.04489618
58	rRNA methylation (GO:0031167)	3.04436042
59	UTP biosynthetic process (GO:0006228)	3.03372045
60	water-soluble vitamin biosynthetic process (GO:0042364)	3.02887971
61	terpenoid biosynthetic process (GO:0016114)	3.01514926
62	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.98583123
63	inositol phosphate dephosphorylation (GO:0046855)	2.98583123
64	positive regulation of granulocyte differentiation (GO:0030854)	2.97342523
65	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.94813311
66	macromolecular complex disassembly (GO:0032984)	2.94592503
67	acrosome reaction (GO:0007340)	2.93436229
68	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.89256011
69	inositol phosphate catabolic process (GO:0071545)	2.89165384
70	peptidyl-histidine modification (GO:0018202)	2.86765973
71	synapsis (GO:0007129)	2.85437887
72	regulation of mitochondrial translation (GO:0070129)	2.83740138
73	centriole replication (GO:0007099)	2.81639552
74	CTP metabolic process (GO:0046036)	2.80165814
75	CTP biosynthetic process (GO:0006241)	2.80165814
76	spermatid development (GO:0007286)	2.78561313
77	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.77625088
78	regulation of chronic inflammatory response (GO:0002676)	2.76251522
79	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.75665886
80	DNA damage response, detection of DNA damage (GO:0042769)	2.75641765
81	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.74507187
82	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.72812430
83	ATP biosynthetic process (GO:0006754)	2.72020215
84	protein polyglutamylation (GO:0018095)	2.70180082
85	regulation of isotype switching to IgG isotypes (GO:0048302)	2.69789717
86	cellular component biogenesis (GO:0044085)	2.69623178
87	male meiosis I (GO:0007141)	2.69541742
88	UTP metabolic process (GO:0046051)	2.68347549
89	protein targeting to membrane (GO:0006612)	2.66825886
90	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64447113
91	negative regulation of T-helper cell differentiation (GO:0045623)	2.62959177
92	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.62959177
93	protein-cofactor linkage (GO:0018065)	2.62075328
94	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.61420111
95	DNA deamination (GO:0045006)	2.61347857
96	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.61185314
97	rRNA processing (GO:0006364)	2.59325788
98	positive regulation of prostaglandin secretion (GO:0032308)	2.58861810
99	rRNA metabolic process (GO:0016072)	2.57931134
100	regulation of podosome assembly (GO:0071801)	2.57733572

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.86782590
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.51207937
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.49761435
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.80657174
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.23776805
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.79610947
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.76574185
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.76349408
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.70177305
10	FUS_26573619_Chip-Seq_HEK293_Human	2.64323911
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.58526228
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.39048742
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.35503874
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.22158513
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.20392935
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.18325426
17	VDR_22108803_ChIP-Seq_LS180_Human	2.12085630
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.06184660
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.01434043
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98649518
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.82791942
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.81631763
23	EWS_26573619_Chip-Seq_HEK293_Human	1.80256669
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.74722765
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.71169035
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67275226
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65290217
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.50734676
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.49231417
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49092970
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48728788
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.47452651
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46062806
34	P300_19829295_ChIP-Seq_ESCs_Human	1.45700030
35	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.44920137
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.44793015
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44536182
38	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39651793
39	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.37224081
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35856113
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35487079
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.35449580
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.34855217
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34610676
45	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.34109222
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33524759
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23978322
48	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.23845915
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.19750977
50	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.17083288
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12969842
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12497006
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.11843981
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11802119
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11046855
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.11046855
57	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.08857527
58	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.08446352
59	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.08355130
60	ERA_21632823_ChIP-Seq_H3396_Human	1.07914252
61	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.06832163
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06764709
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06764709
64	DCP1A_22483619_ChIP-Seq_HELA_Human	1.06286484
65	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.05693168
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.05260983
67	BCAT_22108803_ChIP-Seq_LS180_Human	1.02954002
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02508786
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02508786
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02470984
71	NCOR_22424771_ChIP-Seq_293T_Human	1.02224526
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01838322
73	AR_20517297_ChIP-Seq_VCAP_Human	1.01787969
74	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01690578
75	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01376416
76	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.01376416
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99294196
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98979023
79	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97952824
80	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96925672
81	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.96143830
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96080519
83	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.95656547
84	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.95411366
85	GBX2_23144817_ChIP-Seq_PC3_Human	0.95172215
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94593138
87	XRN2_22483619_ChIP-Seq_HELA_Human	0.94200491
88	ERG_20517297_ChIP-Seq_VCAP_Human	0.93178491
89	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.92171860
90	GABP_19822575_ChIP-Seq_HepG2_Human	0.92071930
91	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.91860854
92	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.90162191
93	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.89317518
94	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.89118774
95	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87883730
96	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.86746866
97	AR_25329375_ChIP-Seq_VCAP_Human	0.85953185
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.84896571
99	RUNX2_22187159_ChIP-Seq_PCA_Human	0.84445813
100	TCF4_22108803_ChIP-Seq_LS180_Human	0.83352712

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.51738601
2	MP0003880_abnormal_central_pattern	3.26042146
3	MP0003283_abnormal_digestive_organ	3.15837205
4	MP0006292_abnormal_olfactory_placode	2.99428591
5	MP0005646_abnormal_pituitary_gland	2.86241680
6	MP0002234_abnormal_pharynx_morphology	2.79559136
7	MP0002653_abnormal_ependyma_morphology	2.76492384
8	MP0005410_abnormal_fertilization	2.53973052
9	MP0002837_dystrophic_cardiac_calcinosis	2.42351829
10	MP0009379_abnormal_foot_pigmentation	2.37221546
11	MP0000372_irregular_coat_pigmentation	2.16767946
12	MP0002160_abnormal_reproductive_system	2.13529071
13	MP0000631_abnormal_neuroendocrine_gland	2.13029321
14	MP0001984_abnormal_olfaction	2.08159618
15	MP0006035_abnormal_mitochondrial_morpho	2.00835833
16	MP0002102_abnormal_ear_morphology	2.00704779
17	MP0001529_abnormal_vocalization	2.00651290
18	MP0005645_abnormal_hypothalamus_physiol	1.99914857
19	MP0006276_abnormal_autonomic_nervous	1.99672681
20	MP0006072_abnormal_retinal_apoptosis	1.95664418
21	MP0002638_abnormal_pupillary_reflex	1.93618435
22	MP0001293_anophthalmia	1.91053207
23	MP0008875_abnormal_xenobiotic_pharmacok	1.85953161
24	MP0008872_abnormal_physiological_respon	1.78771343
25	MP0003315_abnormal_perineum_morphology	1.60978220
26	MP0006036_abnormal_mitochondrial_physio	1.60322187
27	MP0002132_abnormal_respiratory_system	1.57137753
28	MP0008058_abnormal_DNA_repair	1.56228507
29	MP0005551_abnormal_eye_electrophysiolog	1.54358303
30	MP0005377_hearing/vestibular/ear_phenot	1.49798603
31	MP0003878_abnormal_ear_physiology	1.49798603
32	MP0002938_white_spotting	1.49567964
33	MP0008877_abnormal_DNA_methylation	1.49148882
34	MP0003567_abnormal_fetal_cardiomyocyte	1.48757126
35	MP0008789_abnormal_olfactory_epithelium	1.48410830
36	MP0002163_abnormal_gland_morphology	1.44222986
37	MP0003718_maternal_effect	1.31784483
38	MP0005253_abnormal_eye_physiology	1.31589028
39	MP0008995_early_reproductive_senescence	1.29384305
40	MP0009697_abnormal_copulation	1.26528820
41	MP0001905_abnormal_dopamine_level	1.26035800
42	MP0005310_abnormal_salivary_gland	1.25805779
43	MP0000049_abnormal_middle_ear	1.25224502
44	MP0002277_abnormal_respiratory_mucosa	1.24118711
45	MP0001968_abnormal_touch/_nociception	1.23918910
46	MP0001929_abnormal_gametogenesis	1.23889261
47	MP0003698_abnormal_male_reproductive	1.22930226
48	MP0005389_reproductive_system_phenotype	1.22588208
49	MP0001485_abnormal_pinna_reflex	1.21233753
50	MP0002210_abnormal_sex_determination	1.19160868
51	MP0003119_abnormal_digestive_system	1.16684448
52	MP0008057_abnormal_DNA_replication	1.16589185
53	MP0003186_abnormal_redox_activity	1.15119052
54	MP0005084_abnormal_gallbladder_morpholo	1.12479214
55	MP0010386_abnormal_urinary_bladder	1.09260492
56	MP0005394_taste/olfaction_phenotype	1.07011193
57	MP0005499_abnormal_olfactory_system	1.07011193
58	MP0002736_abnormal_nociception_after	1.05930271
59	MP0004142_abnormal_muscle_tone	1.05648375
60	MP0002233_abnormal_nose_morphology	1.04153509
61	MP0009745_abnormal_behavioral_response	1.03252199
62	MP0001348_abnormal_lacrimal_gland	1.03009235
63	MP0005391_vision/eye_phenotype	0.98522561
64	MP0005379_endocrine/exocrine_gland_phen	0.97037465
65	MP0001145_abnormal_male_reproductive	0.95059696
66	MP0003786_premature_aging	0.94888238
67	MP0000653_abnormal_sex_gland	0.94776076
68	MP0004133_heterotaxia	0.94655269
69	MP0002735_abnormal_chemical_nociception	0.94428929
70	MP0003011_delayed_dark_adaptation	0.92047719
71	MP0005187_abnormal_penis_morphology	0.91729890
72	MP0008775_abnormal_heart_ventricle	0.91405010
73	MP0002876_abnormal_thyroid_physiology	0.89752385
74	MP0004215_abnormal_myocardial_fiber	0.87583645
75	MP0002734_abnormal_mechanical_nocicepti	0.87252492
76	MP0001873_stomach_inflammation	0.87203300
77	MP0002752_abnormal_somatic_nervous	0.85424980
78	MP0005195_abnormal_posterior_eye	0.84484475
79	MP0005647_abnormal_sex_gland	0.84008931
80	MP0001188_hyperpigmentation	0.81368551
81	MP0005330_cardiomyopathy	0.81125117
82	MP0004084_abnormal_cardiac_muscle	0.80958053
83	MP0003221_abnormal_cardiomyocyte_apopto	0.80124679
84	MP0000749_muscle_degeneration	0.77883080
85	MP0005075_abnormal_melanosome_morpholog	0.77294167
86	MP0001727_abnormal_embryo_implantation	0.76216919
87	MP0001502_abnormal_circadian_rhythm	0.76048249
88	MP0001440_abnormal_grooming_behavior	0.75749439
89	MP0002557_abnormal_social/conspecific_i	0.75296469
90	MP0006138_congestive_heart_failure	0.74267235
91	MP0003938_abnormal_ear_development	0.74019043
92	MP0003806_abnormal_nucleotide_metabolis	0.73986113
93	MP0001661_extended_life_span	0.73776736
94	MP0004742_abnormal_vestibular_system	0.72636698
95	MP0003890_abnormal_embryonic-extraembry	0.72370896
96	MP0001286_abnormal_eye_development	0.71870075
97	MP0002095_abnormal_skin_pigmentation	0.71574006
98	MP0009046_muscle_twitch	0.70736162
99	MP0002751_abnormal_autonomic_nervous	0.69812844
100	MP0001486_abnormal_startle_reflex	0.69141266

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal pupillary function (HP:0007686)	5.61727705
2	Acute necrotizing encephalopathy (HP:0006965)	4.70412575
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.30763120
4	Acute encephalopathy (HP:0006846)	4.17066482
5	Progressive macrocephaly (HP:0004481)	4.01276921
6	Pancreatic fibrosis (HP:0100732)	3.87696246
7	Colon cancer (HP:0003003)	3.80059617
8	Mitochondrial inheritance (HP:0001427)	3.74993309
9	Congenital stationary night blindness (HP:0007642)	3.72456016
10	Molar tooth sign on MRI (HP:0002419)	3.72245440
11	Abnormality of midbrain morphology (HP:0002418)	3.72245440
12	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.37121196
13	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.37121196
14	Increased CSF lactate (HP:0002490)	3.23462166
15	Cerebral edema (HP:0002181)	3.21125655
16	Pancreatic cysts (HP:0001737)	3.18752986
17	Median cleft lip (HP:0000161)	3.14676934
18	Abnormality of cells of the erythroid lineage (HP:0012130)	2.95198589
19	Macrocytic anemia (HP:0001972)	2.91656224
20	Hepatocellular necrosis (HP:0001404)	2.90102823
21	3-Methylglutaconic aciduria (HP:0003535)	2.73273109
22	Reticulocytopenia (HP:0001896)	2.69071048
23	Optic disc pallor (HP:0000543)	2.63875225
24	Abolished electroretinogram (ERG) (HP:0000550)	2.61532224
25	True hermaphroditism (HP:0010459)	2.55688970
26	Chronic hepatic failure (HP:0100626)	2.55516927
27	Congenital, generalized hypertrichosis (HP:0004540)	2.52490643
28	Large for gestational age (HP:0001520)	2.52050812
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.48669407
30	Lipid accumulation in hepatocytes (HP:0006561)	2.45524193
31	Aplastic anemia (HP:0001915)	2.43467375
32	Pendular nystagmus (HP:0012043)	2.40361503
33	Increased hepatocellular lipid droplets (HP:0006565)	2.36274721
34	Chorioretinal atrophy (HP:0000533)	2.30155827
35	Hepatic necrosis (HP:0002605)	2.27741451
36	Absent thumb (HP:0009777)	2.27073469
37	Lactic acidosis (HP:0003128)	2.24879257
38	Abnormal number of erythroid precursors (HP:0012131)	2.24008762
39	Aplasia/hypoplasia of the uterus (HP:0008684)	2.23744591
40	Bony spicule pigmentary retinopathy (HP:0007737)	2.23315047
41	Hyperglycinemia (HP:0002154)	2.19822761
42	Leukodystrophy (HP:0002415)	2.17717895
43	Stenosis of the external auditory canal (HP:0000402)	2.13910596
44	Attenuation of retinal blood vessels (HP:0007843)	2.12891282
45	Increased serum lactate (HP:0002151)	2.12672124
46	Anophthalmia (HP:0000528)	2.12433266
47	Respiratory failure (HP:0002878)	2.10290096
48	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.10059499
49	Renal Fanconi syndrome (HP:0001994)	2.09973080
50	Exercise intolerance (HP:0003546)	2.08018308
51	Hypoplasia of the ulna (HP:0003022)	2.07432015
52	Preaxial hand polydactyly (HP:0001177)	2.06758938
53	Chorioretinal coloboma (HP:0000567)	2.06505351
54	Nephronophthisis (HP:0000090)	2.06050022
55	Short tibia (HP:0005736)	2.02791842
56	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.01151345
57	Anencephaly (HP:0002323)	1.98572007
58	Pallor (HP:0000980)	1.98208569
59	Opisthotonus (HP:0002179)	1.96995788
60	Congenital sensorineural hearing impairment (HP:0008527)	1.96206725
61	Cystic liver disease (HP:0006706)	1.95491902
62	Sclerocornea (HP:0000647)	1.95025228
63	Triphalangeal thumb (HP:0001199)	1.89554476
64	Abnormal respiratory motile cilium physiology (HP:0012261)	1.88111087
65	Constricted visual fields (HP:0001133)	1.87229664
66	Optic nerve hypoplasia (HP:0000609)	1.86957375
67	Lethargy (HP:0001254)	1.86158382
68	Occipital encephalocele (HP:0002085)	1.85925062
69	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.85882753
70	Cleft eyelid (HP:0000625)	1.85482405
71	Abnormality of DNA repair (HP:0003254)	1.84351634
72	Septo-optic dysplasia (HP:0100842)	1.83848060
73	Medial flaring of the eyebrow (HP:0010747)	1.81963430
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81436623
75	Abnormality of macular pigmentation (HP:0008002)	1.80955684
76	Absent/shortened dynein arms (HP:0200106)	1.80696441
77	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.80696441
78	Pancytopenia (HP:0001876)	1.80512065
79	Methylmalonic acidemia (HP:0002912)	1.80508501
80	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79924365
81	Postaxial foot polydactyly (HP:0001830)	1.79325565
82	Progressive microcephaly (HP:0000253)	1.78650018
83	Male pseudohermaphroditism (HP:0000037)	1.78453868
84	Reduced antithrombin III activity (HP:0001976)	1.77658413
85	Forearm undergrowth (HP:0009821)	1.77620123
86	Congenital hepatic fibrosis (HP:0002612)	1.77591472
87	Testicular atrophy (HP:0000029)	1.77542000
88	Exertional dyspnea (HP:0002875)	1.77462211
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77320885
90	Increased intramyocellular lipid droplets (HP:0012240)	1.76028634
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74087837
92	Abnormality of the renal medulla (HP:0100957)	1.73252030
93	Abnormal ciliary motility (HP:0012262)	1.72922422
94	Iris coloboma (HP:0000612)	1.70995639
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.70593524
96	Abnormal respiratory epithelium morphology (HP:0012253)	1.70593524
97	Meckel diverticulum (HP:0002245)	1.69898656
98	Methylmalonic aciduria (HP:0012120)	1.68656042
99	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.67356223
100	Hypoplasia of the radius (HP:0002984)	1.66767217

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	3.73755075
2	VRK2	3.48254596
3	PINK1	3.28237281
4	PBK	2.79119882
5	TNIK	2.67502350
6	PLK4	2.50551608
7	TLK1	2.43194394
8	NME1	2.41312130
9	VRK1	2.25378628
10	CASK	2.14668513
11	ADRBK2	2.11126306
12	TXK	2.03820790
13	ZAK	2.02627307
14	STK38L	2.02264097
15	PIK3CA	1.95451170
16	GRK5	1.91993206
17	WNK3	1.90686091
18	STK16	1.85297783
19	WEE1	1.84328509
20	GRK1	1.80353982
21	BCKDK	1.76309045
22	PNCK	1.73720511
23	DYRK2	1.71038500
24	MAP4K2	1.70534747
25	DYRK3	1.50922000
26	TAF1	1.47924939
27	DAPK2	1.40036756
28	BMPR1B	1.38009826
29	MAP2K7	1.31345064
30	OBSCN	1.30756151
31	FRK	1.24907976
32	STK4	1.23290982
33	MAPKAPK5	1.20833814
34	MATK	1.16403325
35	NEK2	1.13474235
36	INSRR	1.02597457
37	CDC7	1.01268816
38	PLK2	0.97427019
39	CSNK1G2	0.97271173
40	CDK8	0.93728901
41	DAPK1	0.91600328
42	SRPK1	0.89570597
43	CSNK1G3	0.89119194
44	MST4	0.89113906
45	NLK	0.88899058
46	MAPK13	0.88849094
47	GRK7	0.87577262
48	DAPK3	0.86683948
49	TSSK6	0.84434436
50	MARK3	0.84289496
51	STK3	0.84155400
52	EIF2AK1	0.83592388
53	MAPK15	0.81248642
54	PLK3	0.81073007
55	NEK1	0.80813247
56	NTRK1	0.79496933
57	TAOK3	0.78882463
58	MYLK	0.75855778
59	NME2	0.73463517
60	PLK1	0.68740943
61	MKNK2	0.67830128
62	CSNK1G1	0.66786467
63	CSNK1A1L	0.66324253
64	ITK	0.64866232
65	MAP3K4	0.64442879
66	CDK19	0.63977344
67	TGFBR1	0.63210425
68	MELK	0.61956871
69	ABL2	0.61731864
70	IKBKB	0.60618284
71	WNK4	0.60475072
72	CDK3	0.59338120
73	LRRK2	0.58591615
74	PTK2B	0.54941549
75	ADRBK1	0.54717429
76	TESK2	0.54699960
77	PDK2	0.54501552
78	RPS6KA5	0.52527669
79	MKNK1	0.52365983
80	TNK2	0.51856362
81	KDR	0.51101572
82	PRKCQ	0.51077063
83	PRKCG	0.50602499
84	AURKA	0.49153289
85	MAPKAPK3	0.46713326
86	PAK3	0.46545106
87	AURKB	0.44703629
88	TIE1	0.44702976
89	MAP2K2	0.43335278
90	STK24	0.40809024
91	CSNK2A2	0.37095438
92	PIK3CG	0.36275983
93	BRD4	0.34626361
94	PRKCE	0.32890706
95	CSNK2A1	0.32345695
96	PRKD3	0.29717638
97	PASK	0.29420588
98	LATS1	0.29084048
99	ATR	0.28490989
100	CSNK1A1	0.27605518

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.10962507
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.99921803
3	Parkinsons disease_Homo sapiens_hsa05012	3.49624768
4	Proteasome_Homo sapiens_hsa03050	3.28186155
5	RNA polymerase_Homo sapiens_hsa03020	3.17699777
6	Mismatch repair_Homo sapiens_hsa03430	2.55449387
7	Protein export_Homo sapiens_hsa03060	2.49648005
8	Sulfur relay system_Homo sapiens_hsa04122	2.36398975
9	Huntingtons disease_Homo sapiens_hsa05016	2.29515295
10	DNA replication_Homo sapiens_hsa03030	2.19529643
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13877341
12	Alzheimers disease_Homo sapiens_hsa05010	2.10179349
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.04753929
14	Phototransduction_Homo sapiens_hsa04744	2.02436774
15	Cardiac muscle contraction_Homo sapiens_hsa04260	2.01683389
16	Homologous recombination_Homo sapiens_hsa03440	1.96522859
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.78911943
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.78571106
19	Asthma_Homo sapiens_hsa05310	1.66754531
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65191579
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.65170188
22	RNA degradation_Homo sapiens_hsa03018	1.56339318
23	Folate biosynthesis_Homo sapiens_hsa00790	1.46415382
24	Spliceosome_Homo sapiens_hsa03040	1.45835532
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.40420104
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.38173776
27	Purine metabolism_Homo sapiens_hsa00230	1.33520948
28	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.28930099
29	Base excision repair_Homo sapiens_hsa03410	1.24650198
30	Basal transcription factors_Homo sapiens_hsa03022	1.23924701
31	Propanoate metabolism_Homo sapiens_hsa00640	1.21095865
32	Allograft rejection_Homo sapiens_hsa05330	1.19375726
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.14418566
34	Olfactory transduction_Homo sapiens_hsa04740	1.14138856
35	RNA transport_Homo sapiens_hsa03013	1.10403423
36	One carbon pool by folate_Homo sapiens_hsa00670	1.08088532
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.06550556
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.04766328
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.02165663
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01049659
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00043939
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.99038663
43	Peroxisome_Homo sapiens_hsa04146	0.98392279
44	Butanoate metabolism_Homo sapiens_hsa00650	0.98068235
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97699456
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88507267
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.88238949
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.83206810
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82574790
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78388062
51	Metabolic pathways_Homo sapiens_hsa01100	0.78319353
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76109238
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74051297
54	Linoleic acid metabolism_Homo sapiens_hsa00591	0.71765271
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.71186369
56	Glutathione metabolism_Homo sapiens_hsa00480	0.66893951
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65726568
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65697820
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.65203518
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.64712208
61	Regulation of autophagy_Homo sapiens_hsa04140	0.63210153
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62720028
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.62603702
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61998738
65	Retinol metabolism_Homo sapiens_hsa00830	0.58461437
66	Tyrosine metabolism_Homo sapiens_hsa00350	0.56695285
67	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56618053
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.55736886
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51276799
70	Taste transduction_Homo sapiens_hsa04742	0.50818592
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.49676112
72	Nicotine addiction_Homo sapiens_hsa05033	0.49137540
73	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.44046266
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41737795
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41512997
76	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.41317852
77	Fatty acid elongation_Homo sapiens_hsa00062	0.39169794
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38600053
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37743884
80	Sulfur metabolism_Homo sapiens_hsa00920	0.37683589
81	Fatty acid degradation_Homo sapiens_hsa00071	0.35293527
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.33584959
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.31103853
84	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.30952362
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30732650
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.30653105
87	Antigen processing and presentation_Homo sapiens_hsa04612	0.29633985
88	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.29439767
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.28694949
90	Alcoholism_Homo sapiens_hsa05034	0.28233850
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.27008335
92	Non-homologous end-joining_Homo sapiens_hsa03450	0.26806512
93	GABAergic synapse_Homo sapiens_hsa04727	0.24242267
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24082972
95	mRNA surveillance pathway_Homo sapiens_hsa03015	0.23393340
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.23339317
97	p53 signaling pathway_Homo sapiens_hsa04115	0.20929423
98	Caffeine metabolism_Homo sapiens_hsa00232	0.20868184
99	Primary immunodeficiency_Homo sapiens_hsa05340	0.19598222
100	Morphine addiction_Homo sapiens_hsa05032	0.18321409

PSPC1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »