ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	7.16129286
2	male meiosis (GO:0007140)	6.30347205
3	melanin biosynthetic process (GO:0042438)	5.94783787
4	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.80962852
5	synapsis (GO:0007129)	5.65307436
6	DNA methylation involved in gamete generation (GO:0043046)	5.59405388
7	melanin metabolic process (GO:0006582)	5.38104283
8	regulation of translational termination (GO:0006449)	5.33962595
9	secondary metabolite biosynthetic process (GO:0044550)	5.18449267
10	tachykinin receptor signaling pathway (GO:0007217)	5.11447630
11	regulation of uterine smooth muscle contraction (GO:0070472)	4.62099557
12	histone exchange (GO:0043486)	4.26613185
13	meiotic nuclear division (GO:0007126)	4.18000263
14	positive regulation of protein homodimerization activity (GO:0090073)	4.13347101
15	regulation of mitochondrial translation (GO:0070129)	4.09421949
16	regulation of oxidative phosphorylation (GO:0002082)	4.09117511
17	regulation of cellular respiration (GO:0043457)	4.02986354
18	chromatin remodeling at centromere (GO:0031055)	3.88650497
19	purine nucleobase biosynthetic process (GO:0009113)	3.87143967
20	neurotransmitter uptake (GO:0001504)	3.80835450
21	CENP-A containing nucleosome assembly (GO:0034080)	3.79291192
22	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.65942009
23	cellular response to nitric oxide (GO:0071732)	3.57126712
24	response to pheromone (GO:0019236)	3.51071391
25	male meiosis I (GO:0007141)	3.36893211
26	nucleobase biosynthetic process (GO:0046112)	3.31449058
27	cullin deneddylation (GO:0010388)	3.29850422
28	DNA replication-dependent nucleosome assembly (GO:0006335)	3.25196904
29	DNA replication-dependent nucleosome organization (GO:0034723)	3.25196904
30	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.24172339
31	binding of sperm to zona pellucida (GO:0007339)	3.23006829
32	purine nucleotide salvage (GO:0032261)	3.21456632
33	proteasome assembly (GO:0043248)	3.20876750
34	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.16089489
35	negative regulation of cell size (GO:0045792)	3.13850921
36	pigment biosynthetic process (GO:0046148)	3.12329890
37	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.11990837
38	deoxyribose phosphate catabolic process (GO:0046386)	3.10846501
39	positive regulation of response to oxidative stress (GO:1902884)	3.09667116
40	positive regulation of cellular response to oxidative stress (GO:1900409)	3.09667116
41	chromosome organization involved in meiosis (GO:0070192)	3.09268228
42	meiotic chromosome segregation (GO:0045132)	3.08050965
43	spermatid development (GO:0007286)	3.07052817
44	positive regulation of T cell cytokine production (GO:0002726)	3.06471986
45	DNA deamination (GO:0045006)	3.05316189
46	meiosis I (GO:0007127)	3.02275289
47	regulation of feeding behavior (GO:0060259)	3.01994613
48	mismatch repair (GO:0006298)	2.99169119
49	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.97091517
50	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.95110680
51	regulation of oxidative stress-induced neuron death (GO:1903203)	2.94564004
52	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.92770860
53	galactose catabolic process (GO:0019388)	2.92396797
54	protein deneddylation (GO:0000338)	2.92017949
55	regulation of cellular amino acid metabolic process (GO:0006521)	2.91309580
56	acrosome reaction (GO:0007340)	2.89310864
57	protein K6-linked ubiquitination (GO:0085020)	2.87498207
58	IMP metabolic process (GO:0046040)	2.86259182
59	rRNA modification (GO:0000154)	2.84370633
60	replication fork processing (GO:0031297)	2.84203664
61	resolution of meiotic recombination intermediates (GO:0000712)	2.83378672
62	stress fiber assembly (GO:0043149)	2.77850900
63	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.77542069
64	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.76915651
65	ketone body metabolic process (GO:1902224)	2.75263655
66	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.75041853
67	protein K11-linked deubiquitination (GO:0035871)	2.71025364
68	ether lipid metabolic process (GO:0046485)	2.70547241
69	regulation of dopamine metabolic process (GO:0042053)	2.68622707
70	regulation of catecholamine metabolic process (GO:0042069)	2.68622707
71	polyamine biosynthetic process (GO:0006596)	2.67876207
72	IMP biosynthetic process (GO:0006188)	2.67643037
73	hepatocyte apoptotic process (GO:0097284)	2.66789705
74	glucosamine-containing compound catabolic process (GO:1901072)	2.63830123
75	histone H2A acetylation (GO:0043968)	2.63507871
76	nuclear pore complex assembly (GO:0051292)	2.62869206
77	sister chromatid cohesion (GO:0007062)	2.62528791
78	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.62048825
79	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.62048825
80	ribosome assembly (GO:0042255)	2.61922119
81	spliceosomal snRNP assembly (GO:0000387)	2.59707589
82	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.59598371
83	base-excision repair (GO:0006284)	2.58904987
84	negative regulation of ligase activity (GO:0051352)	2.58826861
85	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.58826861
86	histone mRNA metabolic process (GO:0008334)	2.58669581
87	DNA strand renaturation (GO:0000733)	2.58285031
88	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.58064255
89	base-excision repair, AP site formation (GO:0006285)	2.57654799
90	rRNA methylation (GO:0031167)	2.57320447
91	sperm-egg recognition (GO:0035036)	2.57031416
92	developmental pigmentation (GO:0048066)	2.56544440
93	pigment metabolic process (GO:0042440)	2.55018585
94	regulation of DNA endoreduplication (GO:0032875)	2.54545107
95	regulation of centriole replication (GO:0046599)	2.54045185
96	phenol-containing compound biosynthetic process (GO:0046189)	2.52118984
97	double-strand break repair via homologous recombination (GO:0000724)	2.50120072
98	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.49491278
99	positive regulation of histone H3-K4 methylation (GO:0051571)	2.48317901
100	recombinational repair (GO:0000725)	2.47881589

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.16548189
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.33170338
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.11568162
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.40331577
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.27826327
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.19804214
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.06803515
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.06607485
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.96923722
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.83199599
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.68433060
12	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.67705640
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.41091176
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.40134084
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.28431402
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.26260374
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.24065477
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18337221
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.15278793
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.06750394
21	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.05673741
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99902571
23	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.87413778
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.86044045
25	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.82134254
26	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.78595339
27	AR_21909140_ChIP-Seq_LNCAP_Human	1.77594989
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.73839758
29	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.73161379
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67705253
31	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.66928817
32	VDR_22108803_ChIP-Seq_LS180_Human	1.65544042
33	DCP1A_22483619_ChIP-Seq_HELA_Human	1.65335404
34	FUS_26573619_Chip-Seq_HEK293_Human	1.63308238
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.63001527
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.61163498
37	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.59254659
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55126340
39	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.54393290
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.52733680
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48020933
42	GATA1_22025678_ChIP-Seq_K562_Human	1.43879249
43	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.42752971
44	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.41458632
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.41381650
46	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.41227132
47	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.40504333
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.37421992
49	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.33339804
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30850494
51	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.25975969
52	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.25033444
53	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.23346575
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.20820786
55	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.20112069
56	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13737747
57	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.09834712
58	XRN2_22483619_ChIP-Seq_HELA_Human	1.09326001
59	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.09241748
60	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.08243675
61	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.07998276
62	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.07520718
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07434206
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.07434206
65	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.03778447
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.03676070
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.03111562
68	NCOR_22424771_ChIP-Seq_293T_Human	1.02302309
69	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02021151
70	KDM5A_27292631_Chip-Seq_BREAST_Human	0.99128987
71	ERG_20517297_ChIP-Seq_VCAP_Human	0.99056365
72	GATA3_26560356_Chip-Seq_TH2_Human	0.98684064
73	PHF8_20622853_ChIP-Seq_HELA_Human	0.96724493
74	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.94484544
75	EWS_26573619_Chip-Seq_HEK293_Human	0.93989641
76	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.93510998
77	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.91050359
78	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.90745933
79	SPI1_23547873_ChIP-Seq_NB4_Human	0.90510084
80	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.88010753
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.87616867
82	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87574527
83	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87005886
84	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.86526984
85	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.85054335
86	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.84604455
87	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.84263275
88	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.82645969
89	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.82223945
90	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.81434143
91	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.81240762
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.81125259
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.80985559
94	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.80705906
95	NFYB_21822215_ChIP-Seq_K562_Human	0.80287540
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.80007135
97	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.79703817
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.78433124
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.77491072
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.76832804

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	6.91928339
2	MP0002102_abnormal_ear_morphology	5.44776521
3	MP0005645_abnormal_hypothalamus_physiol	3.87304369
4	MP0005075_abnormal_melanosome_morpholog	3.82621338
5	MP0005410_abnormal_fertilization	3.31468008
6	MP0010094_abnormal_chromosome_stability	3.22728807
7	MP0003646_muscle_fatigue	3.16100054
8	MP0003806_abnormal_nucleotide_metabolis	3.14464746
9	MP0008877_abnormal_DNA_methylation	3.05076758
10	MP0005408_hypopigmentation	2.50771626
11	MP0003693_abnormal_embryo_hatching	2.24584140
12	MP0000015_abnormal_ear_pigmentation	2.22063093
13	MP0008057_abnormal_DNA_replication	2.03743106
14	MP0004147_increased_porphyrin_level	1.97406567
15	MP0005174_abnormal_tail_pigmentation	1.90780991
16	MP0004957_abnormal_blastocyst_morpholog	1.87782585
17	MP0006036_abnormal_mitochondrial_physio	1.84969766
18	MP0003136_yellow_coat_color	1.82119976
19	MP0008058_abnormal_DNA_repair	1.82082994
20	MP0003718_maternal_effect	1.78667723
21	MP0004885_abnormal_endolymph	1.78602752
22	MP0005646_abnormal_pituitary_gland	1.72382568
23	MP0003786_premature_aging	1.70663660
24	MP0001929_abnormal_gametogenesis	1.70321465
25	MP0006072_abnormal_retinal_apoptosis	1.68917298
26	MP0002132_abnormal_respiratory_system	1.67745830
27	MP0001188_hyperpigmentation	1.61670714
28	MP0005647_abnormal_sex_gland	1.60270542
29	MP0002160_abnormal_reproductive_system	1.57856389
30	MP0003111_abnormal_nucleus_morphology	1.56841223
31	MP0002396_abnormal_hematopoietic_system	1.54581901
32	MP0001905_abnormal_dopamine_level	1.53260208
33	MP0002095_abnormal_skin_pigmentation	1.48221812
34	MP0008004_abnormal_stomach_pH	1.48084145
35	MP0008007_abnormal_cellular_replicative	1.47851036
36	MP0003763_abnormal_thymus_physiology	1.46543193
37	MP0005171_absent_coat_pigmentation	1.44415700
38	MP0003698_abnormal_male_reproductive	1.41880205
39	MP0003315_abnormal_perineum_morphology	1.40833195
40	MP0005253_abnormal_eye_physiology	1.37694148
41	MP0002090_abnormal_vision	1.36734848
42	MP0002877_abnormal_melanocyte_morpholog	1.36617355
43	MP0000427_abnormal_hair_cycle	1.29510762
44	MP0004381_abnormal_hair_follicle	1.28819310
45	MP0000371_diluted_coat_color	1.26380250
46	MP0002210_abnormal_sex_determination	1.21237024
47	MP0002837_dystrophic_cardiac_calcinosis	1.18891249
48	MP0003950_abnormal_plasma_membrane	1.16407427
49	MP0006035_abnormal_mitochondrial_morpho	1.16296212
50	MP0001324_abnormal_eye_pigmentation	1.16222575
51	MP0002938_white_spotting	1.13814171
52	MP0008875_abnormal_xenobiotic_pharmacok	1.11839479
53	MP0009764_decreased_sensitivity_to	1.08674287
54	MP0005389_reproductive_system_phenotype	1.08611673
55	MP0002006_tumorigenesis	1.07293715
56	MP0005671_abnormal_response_to	1.04800649
57	MP0003077_abnormal_cell_cycle	1.04073620
58	MP0003878_abnormal_ear_physiology	1.02289893
59	MP0005377_hearing/vestibular/ear_phenot	1.02289893
60	MP0002166_altered_tumor_susceptibility	0.98555318
61	MP0001145_abnormal_male_reproductive	0.95317731
62	MP0000653_abnormal_sex_gland	0.94655763
63	MP0009840_abnormal_foam_cell	0.90813662
64	MP0008932_abnormal_embryonic_tissue	0.88510809
65	MP0000631_abnormal_neuroendocrine_gland	0.87372807
66	MP0001664_abnormal_digestion	0.84859283
67	MP0000383_abnormal_hair_follicle	0.83182812
68	MP0010678_abnormal_skin_adnexa	0.81339992
69	MP0004019_abnormal_vitamin_homeostasis	0.77801547
70	MP0000013_abnormal_adipose_tissue	0.76096950
71	MP0002161_abnormal_fertility/fecundity	0.74057899
72	MP0009785_altered_susceptibility_to	0.71445229
73	MP0002019_abnormal_tumor_incidence	0.70965737
74	MP0008995_early_reproductive_senescence	0.70891988
75	MP0005058_abnormal_lysosome_morphology	0.70170609
76	MP0002148_abnormal_hypersensitivity_rea	0.68434686
77	MP0002060_abnormal_skin_morphology	0.65557368
78	MP0001119_abnormal_female_reproductive	0.65300250
79	MP0003075_altered_response_to	0.64747603
80	MP0000313_abnormal_cell_death	0.63916741
81	MP0002075_abnormal_coat/hair_pigmentati	0.63087308
82	MP0005084_abnormal_gallbladder_morpholo	0.62625761
83	MP0003880_abnormal_central_pattern	0.60695070
84	MP0009765_abnormal_xenobiotic_induced	0.60023558
85	MP0002822_catalepsy	0.58543101
86	MP0004782_abnormal_surfactant_physiolog	0.58534477
87	MP0005451_abnormal_body_composition	0.56383208
88	MP0001984_abnormal_olfaction	0.55056410
89	MP0003172_abnormal_lysosome_physiology	0.54170165
90	MP0005391_vision/eye_phenotype	0.53687100
91	MP0003137_abnormal_impulse_conducting	0.52670771
92	MP0003011_delayed_dark_adaptation	0.52582210
93	MP0003436_decreased_susceptibility_to	0.52196177
94	MP0000703_abnormal_thymus_morphology	0.51616044
95	MP0000358_abnormal_cell_content/	0.50824206
96	MP0003252_abnormal_bile_duct	0.50339014
97	MP0003186_abnormal_redox_activity	0.50326089
98	MP0001293_anophthalmia	0.49346453
99	MP0010234_abnormal_vibrissa_follicle	0.49336640
100	MP0001963_abnormal_hearing_physiology	0.47948343

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Elevated erythrocyte sedimentation rate (HP:0003565)	4.67494526
2	Dyschromatopsia (HP:0007641)	4.54358868
3	Aplasia/Hypoplasia of the macula (HP:0008059)	4.01169363
4	Poor head control (HP:0002421)	3.90764902
5	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.71965632
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.64114399
7	B lymphocytopenia (HP:0010976)	3.45230068
8	Abnormality of B cell number (HP:0010975)	3.12899172
9	Type I transferrin isoform profile (HP:0003642)	3.12773209
10	Median cleft lip (HP:0000161)	3.06653525
11	Fibular hypoplasia (HP:0003038)	3.05239835
12	Abnormal protein glycosylation (HP:0012346)	3.05082670
13	Abnormal glycosylation (HP:0012345)	3.05082670
14	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.05082670
15	Abnormal protein N-linked glycosylation (HP:0012347)	3.05082670
16	Increased hepatocellular lipid droplets (HP:0006565)	3.01174086
17	Lipid accumulation in hepatocytes (HP:0006561)	3.00084025
18	Stomatitis (HP:0010280)	2.99830924
19	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.98546395
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.98546395
21	Acute necrotizing encephalopathy (HP:0006965)	2.98015443
22	Degeneration of anterior horn cells (HP:0002398)	2.93116090
23	Abnormality of the anterior horn cell (HP:0006802)	2.93116090
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.88677996
25	IgM deficiency (HP:0002850)	2.83802629
26	Abnormality of chromosome stability (HP:0003220)	2.80026793
27	Blue irides (HP:0000635)	2.78479666
28	Progressive macrocephaly (HP:0004481)	2.77578562
29	Abnormal mitochondria in muscle tissue (HP:0008316)	2.76881573
30	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.75369549
31	Hyperglycinemia (HP:0002154)	2.75360681
32	Limb dystonia (HP:0002451)	2.74602792
33	Clumsiness (HP:0002312)	2.70261544
34	Chromsome breakage (HP:0040012)	2.69392429
35	Acute encephalopathy (HP:0006846)	2.67663232
36	Ragged-red muscle fibers (HP:0003200)	2.65205948
37	Constricted visual fields (HP:0001133)	2.63683569
38	Hypoplasia of the uterus (HP:0000013)	2.61883783
39	Cutaneous melanoma (HP:0012056)	2.59986339
40	Decreased central vision (HP:0007663)	2.59590274
41	Ocular albinism (HP:0001107)	2.58945308
42	Abnormal auditory evoked potentials (HP:0006958)	2.57137828
43	Abnormality of the fovea (HP:0000493)	2.56611249
44	Hypopigmentation of the fundus (HP:0007894)	2.53968697
45	Generalized hypopigmentation (HP:0007513)	2.52977749
46	Increased CSF lactate (HP:0002490)	2.49624786
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.48458496
48	Amyotrophic lateral sclerosis (HP:0007354)	2.46781413
49	Testicular atrophy (HP:0000029)	2.46566092
50	Dysphonia (HP:0001618)	2.46510021
51	IgG deficiency (HP:0004315)	2.45927380
52	Increased intramyocellular lipid droplets (HP:0012240)	2.42562885
53	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.39874130
54	Ependymoma (HP:0002888)	2.37561954
55	Mitochondrial inheritance (HP:0001427)	2.37227718
56	Iris hypopigmentation (HP:0007730)	2.36371714
57	White forelock (HP:0002211)	2.27724368
58	Retinal dysplasia (HP:0007973)	2.25643012
59	Resting tremor (HP:0002322)	2.24704667
60	Hypokinesia (HP:0002375)	2.23606915
61	Tongue fasciculations (HP:0001308)	2.20745712
62	Renal Fanconi syndrome (HP:0001994)	2.20208802
63	Patchy hypopigmentation of hair (HP:0011365)	2.18012727
64	Prostate neoplasm (HP:0100787)	2.17539041
65	Abnormal spermatogenesis (HP:0008669)	2.17259566
66	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.17140401
67	Cerebral edema (HP:0002181)	2.16439621
68	Abnormal lung lobation (HP:0002101)	2.13329702
69	Hypoplasia of the fovea (HP:0007750)	2.10316956
70	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.10316956
71	Reduced antithrombin III activity (HP:0001976)	2.07780412
72	Abnormality of the prostate (HP:0008775)	2.07493081
73	Facial diplegia (HP:0001349)	2.05824765
74	Increased serum lactate (HP:0002151)	2.05681409
75	Increased muscle lipid content (HP:0009058)	2.05480296
76	Aplasia/hypoplasia of the uterus (HP:0008684)	2.04543226
77	Horizontal nystagmus (HP:0000666)	2.04003235
78	Colon cancer (HP:0003003)	2.02208837
79	Freckling (HP:0001480)	2.01993105
80	Abnormality of serum amino acid levels (HP:0003112)	2.00130532
81	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.97884447
82	Tubulointerstitial nephritis (HP:0001970)	1.97491758
83	Sensory axonal neuropathy (HP:0003390)	1.94920092
84	Abnormality of the ileum (HP:0001549)	1.94807103
85	CNS hypomyelination (HP:0003429)	1.93632040
86	Meckel diverticulum (HP:0002245)	1.93350214
87	Congenital stationary night blindness (HP:0007642)	1.93105216
88	Upper motor neuron abnormality (HP:0002127)	1.91217381
89	Congenital sensorineural hearing impairment (HP:0008527)	1.90539772
90	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.88988353
91	Menstrual irregularities (HP:0000858)	1.88668636
92	Lactic acidosis (HP:0003128)	1.88403955
93	Hepatocellular necrosis (HP:0001404)	1.87759267
94	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.87269183
95	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.84622930
96	Bifid tongue (HP:0010297)	1.82377892
97	Exertional dyspnea (HP:0002875)	1.78449499
98	Hamartoma of the eye (HP:0010568)	1.77537446
99	Muscle fibrillation (HP:0010546)	1.74491694
100	Microretrognathia (HP:0000308)	1.72749490

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SCYL2	4.23258789
2	ZAK	4.18768954
3	PINK1	3.75662772
4	EIF2AK1	3.64488528
5	TLK1	2.84783497
6	FGR	2.72355145
7	EIF2AK3	2.57808947
8	PTK2B	2.38841874
9	MET	2.30560707
10	MST1R	2.19986337
11	NEK1	2.17441459
12	WEE1	2.01496896
13	TRIM28	1.99987862
14	NUAK1	1.90959490
15	TESK2	1.86249311
16	PLK2	1.78576303
17	MARK3	1.76524381
18	MAP3K12	1.71452054
19	MKNK1	1.70726457
20	VRK2	1.69298209
21	MATK	1.64087037
22	PLK3	1.55442295
23	TAF1	1.44520941
24	BMPR1B	1.43295999
25	PLK4	1.40415224
26	MAPKAPK5	1.39421336
27	ATR	1.35196547
28	NME2	1.33843061
29	TESK1	1.32671664
30	WNK4	1.30424099
31	TSSK6	1.29456187
32	MYLK	1.28701181
33	LIMK1	1.28222831
34	VRK1	1.26555690
35	GRK6	1.26264697
36	ADRBK2	1.25543271
37	ACVR1B	1.25120973
38	MKNK2	1.24594274
39	PASK	1.21895845
40	RPS6KA5	1.21853005
41	BMPR2	1.19511565
42	CDC7	1.19470993
43	WNK3	1.12802674
44	CDK3	1.09019516
45	PNCK	1.05990466
46	TEC	1.05630568
47	STK3	1.02129074
48	MAP3K14	1.00752023
49	CHEK2	1.00439774
50	MAP4K2	1.00156486
51	CSNK1G3	0.98423298
52	KIT	0.93123477
53	TAOK2	0.93101162
54	SRPK1	0.92357446
55	KDR	0.91027431
56	ITK	0.90990871
57	MAP2K7	0.89430906
58	EIF2AK2	0.87636486
59	FRK	0.87578535
60	ERBB3	0.87050802
61	MST4	0.86606001
62	DAPK1	0.82956714
63	PLK1	0.78934949
64	BCKDK	0.78246119
65	CSNK1A1L	0.77006991
66	GRK5	0.75931418
67	NEK2	0.72963469
68	TTK	0.71017522
69	CSF1R	0.66869387
70	CSNK1G2	0.66264893
71	ADRBK1	0.64910497
72	STK38L	0.60901810
73	CSNK1G1	0.59898463
74	ATM	0.58293499
75	AKT3	0.57111528
76	TNIK	0.56762965
77	BUB1	0.52343550
78	STK16	0.51666411
79	CDK7	0.47400886
80	TAOK3	0.44557783
81	TRPM7	0.41409644
82	CDK19	0.38619076
83	WNK1	0.38315322
84	IKBKB	0.38066628
85	EGFR	0.35987391
86	CDK8	0.34762041
87	CSNK2A1	0.33964821
88	RIPK4	0.33782263
89	LATS1	0.32795063
90	TBK1	0.32749412
91	FES	0.30547099
92	AURKB	0.30501675
93	CHEK1	0.30490158
94	CDK9	0.29017698
95	IGF1R	0.28716700
96	BTK	0.27891716
97	GRK1	0.27622271
98	CSNK1A1	0.26615060
99	PRKCQ	0.25562662
100	MAP2K2	0.25553280

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.60717292
2	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	3.34285414
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.05664780
4	Protein export_Homo sapiens_hsa03060	3.01163593
5	Homologous recombination_Homo sapiens_hsa03440	2.70205076
6	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.69960081
7	Base excision repair_Homo sapiens_hsa03410	2.38954576
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.13289559
9	Asthma_Homo sapiens_hsa05310	2.01835122
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.00948555
11	RNA transport_Homo sapiens_hsa03013	1.99842086
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.97845745
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.97371285
14	DNA replication_Homo sapiens_hsa03030	1.95295815
15	Mismatch repair_Homo sapiens_hsa03430	1.94712450
16	Legionellosis_Homo sapiens_hsa05134	1.94135299
17	Parkinsons disease_Homo sapiens_hsa05012	1.84577488
18	Spliceosome_Homo sapiens_hsa03040	1.73668842
19	Fatty acid elongation_Homo sapiens_hsa00062	1.71328446
20	Basal transcription factors_Homo sapiens_hsa03022	1.66857117
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.64478086
22	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.62929037
23	One carbon pool by folate_Homo sapiens_hsa00670	1.55635952
24	RNA polymerase_Homo sapiens_hsa03020	1.52171233
25	p53 signaling pathway_Homo sapiens_hsa04115	1.37715586
26	Oxidative phosphorylation_Homo sapiens_hsa00190	1.37162962
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.32103043
28	RNA degradation_Homo sapiens_hsa03018	1.31552961
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.31443962
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.23982049
31	Pentose phosphate pathway_Homo sapiens_hsa00030	1.23335653
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23070509
33	Apoptosis_Homo sapiens_hsa04210	1.22177154
34	Allograft rejection_Homo sapiens_hsa05330	1.22006854
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.17394415
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.16488211
37	Arginine biosynthesis_Homo sapiens_hsa00220	1.15699520
38	Shigellosis_Homo sapiens_hsa05131	1.13943001
39	Cell cycle_Homo sapiens_hsa04110	1.10170589
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.10081706
41	Primary immunodeficiency_Homo sapiens_hsa05340	1.06101641
42	Purine metabolism_Homo sapiens_hsa00230	1.06001554
43	Viral myocarditis_Homo sapiens_hsa05416	1.05476189
44	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.04878313
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.02468279
46	Sulfur metabolism_Homo sapiens_hsa00920	1.02135878
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.99128983
48	Rheumatoid arthritis_Homo sapiens_hsa05323	0.97251250
49	Herpes simplex infection_Homo sapiens_hsa05168	0.97246649
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.95925882
51	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.95561882
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.95319166
53	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.94728277
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.94201124
55	Regulation of autophagy_Homo sapiens_hsa04140	0.93403828
56	Propanoate metabolism_Homo sapiens_hsa00640	0.92522366
57	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.89389272
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89141076
59	Phagosome_Homo sapiens_hsa04145	0.87328222
60	Oocyte meiosis_Homo sapiens_hsa04114	0.86522038
61	Folate biosynthesis_Homo sapiens_hsa00790	0.83539418
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.82391651
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.80209290
64	Phototransduction_Homo sapiens_hsa04744	0.79281477
65	Huntingtons disease_Homo sapiens_hsa05016	0.79273666
66	Small cell lung cancer_Homo sapiens_hsa05222	0.76724014
67	Fatty acid degradation_Homo sapiens_hsa00071	0.74632503
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.72848828
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.72095658
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70727198
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.69652894
72	Glutathione metabolism_Homo sapiens_hsa00480	0.69377629
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.68213592
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.68164746
75	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.67867828
76	mRNA surveillance pathway_Homo sapiens_hsa03015	0.64503138
77	Alzheimers disease_Homo sapiens_hsa05010	0.62247988
78	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.62013823
79	Peroxisome_Homo sapiens_hsa04146	0.60527258
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59527633
81	Metabolic pathways_Homo sapiens_hsa01100	0.56438574
82	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.54612350
83	Salmonella infection_Homo sapiens_hsa05132	0.52495848
84	Butanoate metabolism_Homo sapiens_hsa00650	0.51573429
85	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.49196495
86	Olfactory transduction_Homo sapiens_hsa04740	0.46619050
87	Alcoholism_Homo sapiens_hsa05034	0.45533433
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45435097
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44910039
90	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.44479560
91	Other glycan degradation_Homo sapiens_hsa00511	0.42685770
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.42657742
93	Influenza A_Homo sapiens_hsa05164	0.41915441
94	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.41681373
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40464331
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40289753
97	Toxoplasmosis_Homo sapiens_hsa05145	0.39655889
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38859178
99	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.38551299
100	Measles_Homo sapiens_hsa05162	0.37478239

PSPC1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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