PSRC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* regulation of mitotic spindle organization (GO:0060236)4.77934791
2DNA topological change (GO:0006265)4.70220131
3protein localization to kinetochore (GO:0034501)4.65538401
4regulation of gene silencing by RNA (GO:0060966)4.53931059
5regulation of posttranscriptional gene silencing (GO:0060147)4.53931059
6regulation of gene silencing by miRNA (GO:0060964)4.53931059
7DNA ligation (GO:0006266)4.53239470
8mitotic sister chromatid segregation (GO:0000070)4.31861176
9* mitotic metaphase plate congression (GO:0007080)4.24860665
10DNA unwinding involved in DNA replication (GO:0006268)4.21115595
11DNA replication initiation (GO:0006270)4.13362503
12protein localization to chromosome, centromeric region (GO:0071459)4.13029197
13mitotic nuclear envelope disassembly (GO:0007077)4.06508604
14chromosome condensation (GO:0030261)4.03483797
15kinetochore organization (GO:0051383)4.03230512
16nuclear pore organization (GO:0006999)3.96993199
17DNA replication-dependent nucleosome organization (GO:0034723)3.91671746
18DNA replication-dependent nucleosome assembly (GO:0006335)3.91671746
19sister chromatid segregation (GO:0000819)3.91531979
20maturation of SSU-rRNA (GO:0030490)3.91274549
21kinetochore assembly (GO:0051382)3.88856451
22DNA strand elongation involved in DNA replication (GO:0006271)3.86428395
23microtubule depolymerization (GO:0007019)3.86026062
24formation of translation preinitiation complex (GO:0001731)3.79756540
25nuclear envelope disassembly (GO:0051081)3.75897008
26membrane disassembly (GO:0030397)3.75897008
27* metaphase plate congression (GO:0051310)3.75719538
28folic acid-containing compound biosynthetic process (GO:0009396)3.75550182
29ribosomal small subunit assembly (GO:0000028)3.74601740
30chromatin remodeling at centromere (GO:0031055)3.68160599
31DNA strand elongation (GO:0022616)3.67860440
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.66289477
33paraxial mesoderm development (GO:0048339)3.65104212
34nuclear pore complex assembly (GO:0051292)3.64829725
35CENP-A containing nucleosome assembly (GO:0034080)3.62990233
36negative regulation of mitosis (GO:0045839)3.62068820
37protein complex localization (GO:0031503)3.56304182
38DNA replication checkpoint (GO:0000076)3.52391878
39telomere maintenance via semi-conservative replication (GO:0032201)3.51297681
40viral transcription (GO:0019083)3.49979949
41nucleobase biosynthetic process (GO:0046112)3.49065255
42mitotic chromosome condensation (GO:0007076)3.48796346
43IMP biosynthetic process (GO:0006188)3.47771726
44* establishment of chromosome localization (GO:0051303)3.46326265
45protein K6-linked ubiquitination (GO:0085020)3.45689538
46translational termination (GO:0006415)3.43834600
47L-serine metabolic process (GO:0006563)3.43327639
48positive regulation of chromosome segregation (GO:0051984)3.43308713
49attachment of spindle microtubules to kinetochore (GO:0008608)3.38218613
50somatic hypermutation of immunoglobulin genes (GO:0016446)3.37433009
51somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37433009
52DNA replication-independent nucleosome organization (GO:0034724)3.36293897
53DNA replication-independent nucleosome assembly (GO:0006336)3.36293897
54ribosomal large subunit biogenesis (GO:0042273)3.32598717
55DNA packaging (GO:0006323)3.31654266
56* regulation of spindle organization (GO:0090224)3.28515737
57establishment of mitotic spindle localization (GO:0040001)3.28206307
58ribosomal small subunit biogenesis (GO:0042274)3.26462876
59mitotic recombination (GO:0006312)3.25468661
60negative regulation of chromosome segregation (GO:0051985)3.24217053
61heterochromatin organization (GO:0070828)3.22311818
62regulation of telomere maintenance via telomerase (GO:0032210)3.21485003
63spindle checkpoint (GO:0031577)3.21286537
64mitotic cytokinesis (GO:0000281)3.20383114
65ribonucleoprotein complex biogenesis (GO:0022613)3.20060047
66translational initiation (GO:0006413)3.20030906
67ribosome biogenesis (GO:0042254)3.19991531
68DNA geometric change (GO:0032392)3.19978716
69ribosome assembly (GO:0042255)3.19829571
70DNA duplex unwinding (GO:0032508)3.19811175
71regulation of chromosome segregation (GO:0051983)3.19739084
72telomere maintenance via telomere lengthening (GO:0010833)3.18024402
73positive regulation of SMAD protein import into nucleus (GO:0060391)3.17713438
74regulation of helicase activity (GO:0051095)3.16782846
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16206553
76negative regulation of sister chromatid segregation (GO:0033046)3.16206553
77negative regulation of mitotic sister chromatid separation (GO:2000816)3.16206553
78negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16206553
79translational elongation (GO:0006414)3.15642190
80telomere maintenance via recombination (GO:0000722)3.14036456
81regulation of centrosome cycle (GO:0046605)3.12645676
82positive regulation of mitotic sister chromatid separation (GO:1901970)3.12148372
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12148372
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12148372
85regulation of histone H3-K9 methylation (GO:0051570)3.11590018
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11567357
87purine nucleobase biosynthetic process (GO:0009113)3.11296205
88regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11089060
89spindle assembly checkpoint (GO:0071173)3.10887601
90negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.10143525
91mitotic spindle checkpoint (GO:0071174)3.09452598
92regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09268108
93histone exchange (GO:0043486)3.09024261
94protein localization to chromosome (GO:0034502)3.08799958
95mitotic spindle assembly checkpoint (GO:0007094)3.08502653
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.08321592
97regulation of nuclear cell cycle DNA replication (GO:0033262)3.08071553
98mitotic spindle organization (GO:0007052)3.06359622
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05840967
100negative regulation of nuclear division (GO:0051784)3.03550733
101microtubule polymerization or depolymerization (GO:0031109)3.02219952
102negative regulation of histone methylation (GO:0031061)3.01520307
103ATP-dependent chromatin remodeling (GO:0043044)3.00332149
104chromatin assembly or disassembly (GO:0006333)2.98465941
105pre-miRNA processing (GO:0031054)2.98084461
106negative regulation of cell division (GO:0051782)2.97688173
107IMP metabolic process (GO:0046040)2.96889318
108establishment of viral latency (GO:0019043)2.96807986
109spliceosomal snRNP assembly (GO:0000387)2.96713183
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.96492480
111regulation of mitotic sister chromatid separation (GO:0010965)2.96468817
112regulation of mitotic sister chromatid segregation (GO:0033047)2.96468817
113regulation of sister chromatid segregation (GO:0033045)2.96468817
114chromosome segregation (GO:0007059)2.96156005
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93204233
116regulation of sister chromatid cohesion (GO:0007063)2.92006144
117ventricular cardiac muscle cell development (GO:0055015)2.91925114
118pore complex assembly (GO:0046931)2.91627744
119establishment of integrated proviral latency (GO:0075713)2.91369217
120negative regulation of proteasomal protein catabolic process (GO:1901799)2.89616291
121notochord development (GO:0030903)2.85714544
122nuclear envelope organization (GO:0006998)2.85096243
123mitotic nuclear division (GO:0007067)2.83681493
124negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83157220
125spindle assembly involved in mitosis (GO:0090307)2.83026843
126cellular protein complex localization (GO:0034629)2.82660579
127regulation of exit from mitosis (GO:0007096)2.76128595
128meiotic chromosome segregation (GO:0045132)2.76050111
129spindle organization (GO:0007051)2.71307998
130mitotic cell cycle (GO:0000278)2.68834713
131establishment of spindle localization (GO:0051293)2.64868754
132regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59809740
133negative regulation of mRNA processing (GO:0050686)2.58360870
134DNA conformation change (GO:0071103)2.56754610
135negative regulation of proteolysis involved in cellular protein catabolic process (GO:1903051)2.53113419
136mitotic cell cycle checkpoint (GO:0007093)2.50334396
137establishment of mitotic spindle orientation (GO:0000132)2.49822388
138cytoskeleton-dependent cytokinesis (GO:0061640)2.49484520
139regulation of centriole replication (GO:0046599)2.48994687
140peptidyl-arginine omega-N-methylation (GO:0035247)2.48806743
141negative regulation of microtubule depolymerization (GO:0007026)2.47465753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.25457475
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.13104729
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.21222551
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66708162
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43547419
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.30829870
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05137280
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81148902
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58760436
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.42389532
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.40446909
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38378650
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34892655
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.34060217
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.34060217
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.34060217
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.33573388
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.31656738
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28234799
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.26319210
21* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26210213
22XRN2_22483619_ChIP-Seq_HELA_Human2.18698426
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14899671
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08920838
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07941971
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07902914
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.04038611
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01574924
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.00976944
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.96151793
31AR_21909140_ChIP-Seq_LNCAP_Human1.95875402
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.95366150
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94231377
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.89719816
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88357018
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.84793872
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.84767589
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82399281
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.74374673
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71832482
41TTF2_22483619_ChIP-Seq_HELA_Human1.67467593
42VDR_23849224_ChIP-Seq_CD4+_Human1.65626873
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64322639
44DCP1A_22483619_ChIP-Seq_HELA_Human1.59804924
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57394871
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.56158218
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.54861232
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53438827
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.51742104
50FOXP3_21729870_ChIP-Seq_TREG_Human1.51253452
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50081604
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47935058
53* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47444335
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46625805
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46617946
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.46185384
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44782059
58GABP_19822575_ChIP-Seq_HepG2_Human1.44139175
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43541379
60CIITA_25753668_ChIP-Seq_RAJI_Human1.36628296
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36180891
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35951664
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35319311
64MYC_22102868_ChIP-Seq_BL_Human1.34324604
65NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.33469839
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.31963502
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.31818103
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31209041
69ELK1_19687146_ChIP-ChIP_HELA_Human1.30502458
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30156119
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29406034
72SOX2_18692474_ChIP-Seq_MEFs_Mouse1.29177591
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27793508
74KDM5A_27292631_Chip-Seq_BREAST_Human1.24900715
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24155839
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.23764608
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22580396
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21743418
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21704604
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20990126
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20189220
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17667884
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17593426
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15797669
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15561567
86* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14732082
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13006638
88SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12641287
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11935974
90TFEB_21752829_ChIP-Seq_HELA_Human1.11303323
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09317159
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08354090
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08046855
94* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08026896
95NANOG_18692474_ChIP-Seq_MEFs_Mouse1.07921524
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06372171
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05681070
98POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05516358
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04048293
100TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02532163
101* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99196659
102HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99150689
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97266757
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96981576
105GATA1_26923725_Chip-Seq_HPCs_Mouse0.96787748
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96464438
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96178633
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94600156
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94460214
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.92543996
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92382215
112NANOG_18692474_ChIP-Seq_MESCs_Mouse0.91279980
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90254626
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90077588
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88847094
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.87245361
117SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86786301
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85141664
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82636411
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79086669
121ZNF263_19887448_ChIP-Seq_K562_Human0.78972940
122SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.78056569
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76220807
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75529945
125TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.73577943
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73439486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.37353827
2MP0003111_abnormal_nucleus_morphology4.36592802
3MP0010094_abnormal_chromosome_stability4.07973211
4MP0004957_abnormal_blastocyst_morpholog4.03211247
5MP0003077_abnormal_cell_cycle3.68942769
6MP0008057_abnormal_DNA_replication3.09729775
7MP0008058_abnormal_DNA_repair2.83016185
8MP0008007_abnormal_cellular_replicative2.72967973
9MP0008932_abnormal_embryonic_tissue2.49832367
10MP0010030_abnormal_orbit_morphology2.47853621
11MP0004133_heterotaxia2.46962675
12MP0000566_synostosis2.41498100
13MP0010352_gastrointestinal_tract_polyps2.40103581
14MP0003941_abnormal_skin_development2.38276464
15MP0004859_abnormal_synaptic_plasticity2.23952669
16MP0000350_abnormal_cell_proliferation2.23210844
17MP0001730_embryonic_growth_arrest2.22411437
18MP0003123_paternal_imprinting2.21447012
19MP0002653_abnormal_ependyma_morphology2.03117228
20MP0010307_abnormal_tumor_latency1.95482247
21MP0001672_abnormal_embryogenesis/_devel1.90478089
22MP0005380_embryogenesis_phenotype1.90478089
23MP0001529_abnormal_vocalization1.88551449
24MP0002085_abnormal_embryonic_tissue1.87969342
25MP0002084_abnormal_developmental_patter1.85223405
26MP0001697_abnormal_embryo_size1.80462551
27MP0003786_premature_aging1.72642345
28MP0004197_abnormal_fetal_growth/weight/1.68822058
29MP0003718_maternal_effect1.68760747
30MP0003119_abnormal_digestive_system1.65484765
31MP0001293_anophthalmia1.64105960
32MP0003984_embryonic_growth_retardation1.62778261
33MP0000778_abnormal_nervous_system1.62496409
34MP0003890_abnormal_embryonic-extraembry1.62308800
35MP0002088_abnormal_embryonic_growth/wei1.60141423
36MP0005171_absent_coat_pigmentation1.59530169
37MP0002086_abnormal_extraembryonic_tissu1.56853802
38MP0003806_abnormal_nucleotide_metabolis1.56604041
39MP0002080_prenatal_lethality1.54025341
40MP0006292_abnormal_olfactory_placode1.53230741
41MP0009672_abnormal_birth_weight1.52609366
42MP0005076_abnormal_cell_differentiation1.50423369
43MP0001346_abnormal_lacrimal_gland1.47329040
44MP0003705_abnormal_hypodermis_morpholog1.44536847
45MP0003121_genomic_imprinting1.43867314
46MP0000490_abnormal_crypts_of1.40773687
47MP0003880_abnormal_central_pattern1.37580951
48MP0002938_white_spotting1.37400281
49MP0008877_abnormal_DNA_methylation1.36753705
50MP0003136_yellow_coat_color1.35437894
51MP0009053_abnormal_anal_canal1.34091457
52MP0000516_abnormal_urinary_system1.33262918
53MP0005367_renal/urinary_system_phenotyp1.33262918
54MP0000579_abnormal_nail_morphology1.31399765
55MP0000313_abnormal_cell_death1.28426606
56MP0002249_abnormal_larynx_morphology1.25103272
57MP0000537_abnormal_urethra_morphology1.24790646
58MP0003937_abnormal_limbs/digits/tail_de1.23526489
59MP0002111_abnormal_tail_morphology1.23445864
60MP0003567_abnormal_fetal_cardiomyocyte1.22896660
61MP0009379_abnormal_foot_pigmentation1.19744109
62MP0004858_abnormal_nervous_system1.18690710
63MP0002396_abnormal_hematopoietic_system1.16462790
64MP0003315_abnormal_perineum_morphology1.16173401
65MP0005394_taste/olfaction_phenotype1.15219343
66MP0005499_abnormal_olfactory_system1.15219343
67MP0002019_abnormal_tumor_incidence1.14648071
68MP0003566_abnormal_cell_adhesion1.13840332
69MP0001299_abnormal_eye_distance/1.13675909
70MP0003283_abnormal_digestive_organ1.09732250
71MP0001286_abnormal_eye_development1.09167405
72MP0002152_abnormal_brain_morphology1.08709629
73MP0003938_abnormal_ear_development1.08559238
74MP0004270_analgesia1.06604937
75MP0008789_abnormal_olfactory_epithelium1.05084864
76MP0000955_abnormal_spinal_cord1.04511957
77MP0005023_abnormal_wound_healing1.04414743
78MP0003122_maternal_imprinting1.04340294
79MP0002210_abnormal_sex_determination1.02836337
80MP0000432_abnormal_head_morphology1.00826750
81MP0001849_ear_inflammation1.00103432
82MP0004811_abnormal_neuron_physiology0.99064123
83MP0001915_intracranial_hemorrhage0.95839004
84MP0000858_altered_metastatic_potential0.95804375
85MP0000428_abnormal_craniofacial_morphol0.95716823
86MP0005423_abnormal_somatic_nervous0.95364735
87MP0002697_abnormal_eye_size0.93090735
88MP0005501_abnormal_skin_physiology0.91921983
89MP0001145_abnormal_male_reproductive0.91319673
90MP0002736_abnormal_nociception_after0.90469744
91MP0005623_abnormal_meninges_morphology0.90163112
92MP0002092_abnormal_eye_morphology0.89986944
93MP0003755_abnormal_palate_morphology0.89411183
94MP0004808_abnormal_hematopoietic_stem0.88332870
95MP0001177_atelectasis0.86621018
96MP0003635_abnormal_synaptic_transmissio0.86116401
97MP0000049_abnormal_middle_ear0.85192272
98MP0000534_abnormal_ureter_morphology0.85186159
99MP0002932_abnormal_joint_morphology0.84147064
100MP0003935_abnormal_craniofacial_develop0.83833467
101MP0000733_abnormal_muscle_development0.83598704
102MP0005391_vision/eye_phenotype0.81941557
103MP0003385_abnormal_body_wall0.81621336
104MP0002282_abnormal_trachea_morphology0.81501401
105MP0003861_abnormal_nervous_system0.81177505
106MP0003942_abnormal_urinary_system0.80727346
107MP0000647_abnormal_sebaceous_gland0.80713837
108MP0002081_perinatal_lethality0.80319205
109MP0002160_abnormal_reproductive_system0.79474820
110MP0000653_abnormal_sex_gland0.78655738
111MP0005384_cellular_phenotype0.77570413
112MP0002184_abnormal_innervation0.77316853
113MP0001984_abnormal_olfaction0.77110055
114MP0000631_abnormal_neuroendocrine_gland0.76851770
115MP0009703_decreased_birth_body0.76375221
116MP0003115_abnormal_respiratory_system0.76333817
117MP0002063_abnormal_learning/memory/cond0.76159472
118MP0005621_abnormal_cell_physiology0.75923581
119MP0002882_abnormal_neuron_morphology0.74378429
120MP0005248_abnormal_Harderian_gland0.74056336
121MP0002114_abnormal_axial_skeleton0.73789666
122MP0003634_abnormal_glial_cell0.73593996
123MP0001119_abnormal_female_reproductive0.72864355
124MP0001340_abnormal_eyelid_morphology0.72107675
125MP0006072_abnormal_retinal_apoptosis0.71465957
126MP0001929_abnormal_gametogenesis0.70293467
127MP0010234_abnormal_vibrissa_follicle0.69599150
128MP0000358_abnormal_cell_content/0.69520810
129MP0002925_abnormal_cardiovascular_devel0.68199409
130MP0005389_reproductive_system_phenotype0.67663433
131MP0000762_abnormal_tongue_morphology0.67573608
132MP0001545_abnormal_hematopoietic_system0.66787525
133MP0005397_hematopoietic_system_phenotyp0.66787525
134MP0000467_abnormal_esophagus_morphology0.64898560
135MP0002116_abnormal_craniofacial_bone0.64423534
136MP0000477_abnormal_intestine_morphology0.64287242
137MP0003936_abnormal_reproductive_system0.63634967
138MP0002233_abnormal_nose_morphology0.63330828
139MP0005508_abnormal_skeleton_morphology0.60644637

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.35385248
2Birth length less than 3rd percentile (HP:0003561)3.92607925
3Ependymoma (HP:0002888)3.90831338
4Breast hypoplasia (HP:0003187)3.80266545
5Reticulocytopenia (HP:0001896)3.67790128
6Chromsome breakage (HP:0040012)3.64428079
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59469787
8Supernumerary spleens (HP:0009799)3.54823795
9Colon cancer (HP:0003003)3.49460261
10Selective tooth agenesis (HP:0001592)3.48013300
11Medulloblastoma (HP:0002885)3.46291483
12Abnormality of the labia minora (HP:0012880)3.32603709
13Absent radius (HP:0003974)3.24849345
14Patellar aplasia (HP:0006443)3.22721324
15Broad distal phalanx of finger (HP:0009836)3.19136596
16Aplasia involving forearm bones (HP:0009822)3.04703646
17Absent forearm bone (HP:0003953)3.04703646
18Aplasia/Hypoplasia of the patella (HP:0006498)3.00536816
19Abdominal situs inversus (HP:0003363)2.99316398
20Abnormality of abdominal situs (HP:0011620)2.99316398
21Rib fusion (HP:0000902)2.90904895
22Oral leukoplakia (HP:0002745)2.90027284
23Rhabdomyosarcoma (HP:0002859)2.88402580
24Astrocytoma (HP:0009592)2.87350689
25Abnormality of the astrocytes (HP:0100707)2.87350689
26Missing ribs (HP:0000921)2.86277940
27Meckel diverticulum (HP:0002245)2.82071968
28Agnosia (HP:0010524)2.80886872
29Hypoplasia of the capital femoral epiphysis (HP:0003090)2.80447747
30Abnormal number of incisors (HP:0011064)2.73438166
31Degeneration of anterior horn cells (HP:0002398)2.71744270
32Abnormality of the anterior horn cell (HP:0006802)2.71744270
33Abnormality of the ileum (HP:0001549)2.71197051
34Carpal bone hypoplasia (HP:0001498)2.69930665
35Insomnia (HP:0100785)2.68589692
36Absent epiphyses (HP:0010577)2.65640254
37Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.65640254
38Absent thumb (HP:0009777)2.63922223
39Abnormality of cells of the erythroid lineage (HP:0012130)2.63878742
40Neoplasm of the oral cavity (HP:0100649)2.62877319
41Aplasia/hypoplasia of the humerus (HP:0006507)2.54015041
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.54008777
43Overriding aorta (HP:0002623)2.52545220
44Glioma (HP:0009733)2.51440638
45Rough bone trabeculation (HP:0100670)2.50961435
46Esophageal atresia (HP:0002032)2.50073884
47Abnormality of chromosome stability (HP:0003220)2.49218490
48Neoplasm of the pancreas (HP:0002894)2.47381528
49Abnormality of the preputium (HP:0100587)2.47149131
50Duodenal stenosis (HP:0100867)2.41338231
51Small intestinal stenosis (HP:0012848)2.41338231
52Partial duplication of thumb phalanx (HP:0009944)2.38895637
53Neoplasm of striated muscle (HP:0009728)2.33364387
54Abnormal number of erythroid precursors (HP:0012131)2.32257699
55Impulsivity (HP:0100710)2.31558373
56Tracheoesophageal fistula (HP:0002575)2.29167053
57Hyperacusis (HP:0010780)2.26814992
58Trismus (HP:0000211)2.25242461
59Abnormal lung lobation (HP:0002101)2.25232692
60Short humerus (HP:0005792)2.25146586
61Septo-optic dysplasia (HP:0100842)2.21657746
62Supernumerary bones of the axial skeleton (HP:0009144)2.19298592
63Premature graying of hair (HP:0002216)2.18575318
6411 pairs of ribs (HP:0000878)2.18052109
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17279726
66Abnormality of the duodenum (HP:0002246)2.15972935
67Supernumerary ribs (HP:0005815)2.13792553
68Macrocytic anemia (HP:0001972)2.13384130
69Atresia of the external auditory canal (HP:0000413)2.13381835
70Shawl scrotum (HP:0000049)2.12572033
71Abnormality of the carotid arteries (HP:0005344)2.11720262
72Hypoplastic pelvis (HP:0008839)2.11648307
73Triphalangeal thumb (HP:0001199)2.10922274
74Myelodysplasia (HP:0002863)2.10737949
75Duplicated collecting system (HP:0000081)2.10457893
76Basal cell carcinoma (HP:0002671)2.09915932
77Deviation of the thumb (HP:0009603)2.08765603
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07897931
79Morphological abnormality of the inner ear (HP:0011390)2.07477860
80Partial duplication of the phalanx of hand (HP:0009999)2.07425031
81Aplasia/Hypoplasia of the sternum (HP:0006714)2.05955754
82Ectopic kidney (HP:0000086)2.04118004
83Asplenia (HP:0001746)2.03207947
84Horseshoe kidney (HP:0000085)2.02503952
85Sloping forehead (HP:0000340)2.02341356
86Nephroblastoma (Wilms tumor) (HP:0002667)2.01980100
87Proximal placement of thumb (HP:0009623)2.01756180
88Pointed chin (HP:0000307)2.01595064
89Gastrointestinal carcinoma (HP:0002672)2.01369863
90Malignant gastrointestinal tract tumors (HP:0006749)2.01369863
91Small epiphyses (HP:0010585)2.01306276
92Vertebral arch anomaly (HP:0008438)2.00815071
93Split foot (HP:0001839)2.00556664
94Premature ovarian failure (HP:0008209)1.99668495
95Ulnar bowing (HP:0003031)1.99091648
96Pallor (HP:0000980)1.97928887
97Renal duplication (HP:0000075)1.96001579
98Squamous cell carcinoma (HP:0002860)1.94618431
99Embryonal renal neoplasm (HP:0011794)1.92925810
100Biliary tract neoplasm (HP:0100574)1.92538053
101Breast aplasia (HP:0100783)1.91734252
102Aplasia/Hypoplasia of the spleen (HP:0010451)1.91060040
103Increased nuchal translucency (HP:0010880)1.89351441
104Short thumb (HP:0009778)1.88708094
105Spastic diplegia (HP:0001264)1.88546365
106Abnormality of the diencephalon (HP:0010662)1.87950446
107Abnormality of cochlea (HP:0000375)1.87614595
108Gastrointestinal atresia (HP:0002589)1.87521936
109Elfin facies (HP:0004428)1.86946030
110Aplastic anemia (HP:0001915)1.86573446
111Bone marrow hypocellularity (HP:0005528)1.86397912
112Trigonocephaly (HP:0000243)1.84789573
113Aplasia/Hypoplasia of the breasts (HP:0010311)1.84218685
114Neoplasm of the colon (HP:0100273)1.84173484
115Rectovaginal fistula (HP:0000143)1.83563418
116Rectal fistula (HP:0100590)1.83563418
117Fused cervical vertebrae (HP:0002949)1.83513756
118High anterior hairline (HP:0009890)1.80667734
119Abnormality of the renal collecting system (HP:0004742)1.78642807
120Oligodactyly (HP:0012165)1.78603610
121Cafe-au-lait spot (HP:0000957)1.78502053
122Stenosis of the external auditory canal (HP:0000402)1.78265461
123Hemivertebrae (HP:0002937)1.78216278
124Spinal muscular atrophy (HP:0007269)1.77575942
125Duplication of thumb phalanx (HP:0009942)1.76434501
126Abnormal trabecular bone morphology (HP:0100671)1.76350215
127Embryonal neoplasm (HP:0002898)1.75590636
128Absent septum pellucidum (HP:0001331)1.74479085
129Turricephaly (HP:0000262)1.74240138
130Broad phalanges of the hand (HP:0009768)1.73683344
131Broad thumb (HP:0011304)1.73424365
132Multiple enchondromatosis (HP:0005701)1.71710716
133Holoprosencephaly (HP:0001360)1.71000154
134Cutaneous syndactyly (HP:0012725)1.69754743
135Coronal craniosynostosis (HP:0004440)1.68112308
136Generalized hypotonia (HP:0001290)1.67129301
137Aplasia involving bones of the extremities (HP:0009825)1.65728301
138Aplasia involving bones of the upper limbs (HP:0009823)1.65728301
139Aplasia of the phalanges of the hand (HP:0009802)1.65728301
140Abnormal gallbladder physiology (HP:0012438)1.65319886
141Cholecystitis (HP:0001082)1.65319886
142Broad finger (HP:0001500)1.64756857
143Shallow orbits (HP:0000586)1.63345774
144Glossoptosis (HP:0000162)1.62010000
145Vertebral hypoplasia (HP:0008417)1.60248475
146Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.60248475
147Abnormality of the septum pellucidum (HP:0007375)1.59560181
148Myokymia (HP:0002411)1.58447708
149Cutaneous finger syndactyly (HP:0010554)1.58294717
150Partial agenesis of the corpus callosum (HP:0001338)1.58246000
151Abnormality of the calcaneus (HP:0008364)1.58167625
152Abnormality of glycolysis (HP:0004366)1.57833661
153Abnormality of chromosome segregation (HP:0002916)1.54935135
154Choanal atresia (HP:0000453)1.54262140
155Tracheomalacia (HP:0002779)1.53565945
156Tetralogy of Fallot (HP:0001636)1.53451754
157Renal agenesis (HP:0000104)1.52398074
158Irregular epiphyses (HP:0010582)1.50942056
159Alacrima (HP:0000522)1.49422813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.62992698
2WEE13.70813540
3CDC73.66749208
4EPHA23.42441946
5TTK3.26707486
6NEK22.85136887
7CDK122.76101266
8NEK12.49903449
9RPS6KB22.38409006
10PLK12.25920940
11EIF2AK12.15573947
12SRPK12.10589128
13UHMK12.08570171
14CDK71.94167464
15TLK11.90303732
16EEF2K1.88429781
17PLK41.78879710
18AURKB1.77472739
19VRK21.74025556
20TSSK61.72547034
21CHEK21.70498777
22ATR1.61477965
23MKNK11.60931117
24MAP3K81.57326859
25PLK31.56636065
26AURKA1.54976100
27PAK41.54890681
28PASK1.52633301
29STK101.48663971
30TESK21.43470246
31LATS21.38361968
32BRSK21.37879104
33PAK61.36331967
34NME21.34514914
35DYRK31.33772837
36CHEK11.33033983
37CDK41.32851394
38MKNK21.32309895
39ACVR1B1.30462783
40STK41.28808523
41VRK11.27000796
42MAPKAPK31.24865918
43MAP3K101.21347491
44ZAK1.20581143
45BRD41.19653106
46EPHA41.16316482
47STK38L1.15759283
48LATS11.14560173
49PIM11.11369559
50SMG11.10372353
51BRSK11.08516923
52CDK61.06186950
53PRKD31.06119494
54FLT31.03908887
55MELK1.03227716
56BRAF1.02606170
57NTRK11.00024134
58PIM20.98893644
59NTRK20.98767850
60RPS6KA40.96382262
61CDK150.96237596
62CDK11A0.95647141
63CDK20.95520177
64PRKCI0.95477935
65AKT30.95461142
66ATM0.94394942
67PKN20.94169590
68ALK0.93382818
69CDK180.93380285
70TGFBR10.93122951
71EIF2AK30.84022591
72CDK140.83066614
73SCYL20.78438402
74PAK10.78100494
75MTOR0.74348285
76STK30.73962918
77CDK10.71006576
78TRIB30.70167337
79TYRO30.68000190
80TNIK0.65607074
81EPHB20.65113784
82CSNK2A20.62929864
83PBK0.62781254
84CDK80.62687958
85FGFR20.61679315
86NME10.60737303
87PLK20.60708377
88TESK10.60647980
89MET0.59876179
90CLK10.59084628
91AKT20.58284942
92PKN10.57066990
93TAF10.56516915
94MINK10.56050843
95EIF2AK20.55303842
96CSNK2A10.55133770
97MARK10.54055586
98NTRK30.53181021
99ARAF0.52198170
100KSR20.51732346
101CSNK1E0.51636579
102DAPK30.51347523
103LRRK20.50449952
104DYRK20.50337848
105ERBB40.49858005
106KSR10.48312460
107PNCK0.48251034
108TAOK20.47704664
109ROCK20.47515864
110CCNB10.46058883
111LIMK10.45457560
112FGFR10.44785707
113BMX0.43353376
114RPS6KA50.41870048
115CHUK0.40543470
116PAK20.39301984
117PRKDC0.39146557
118STK160.38268977
119CSNK1D0.36835109
120PDGFRA0.36655066
121AKT10.35956978
122CDK30.35780585
123DDR20.35645295
124CSNK1G30.35564354
125CAMK2G0.35131379
126PTK20.35124257
127ICK0.34890879
128ERBB20.34624489
129CAMK2B0.33930546
130MAPK10.33548421
131LMTK20.32424888
132PRKCG0.32176876
133MAP2K70.32151643
134MAPK140.32020999
135CSNK1G20.30954254
136MOS0.29729223
137YES10.28314537
138MAP3K110.26438896
139GSK3B0.24610980
140DYRK1B0.24394212
141RPS6KA10.21874077

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.39844223
2Mismatch repair_Homo sapiens_hsa034304.20014266
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54422139
4Ribosome_Homo sapiens_hsa030103.38739617
5Spliceosome_Homo sapiens_hsa030403.30830644
6RNA transport_Homo sapiens_hsa030133.21323240
7Base excision repair_Homo sapiens_hsa034103.02538922
8Homologous recombination_Homo sapiens_hsa034403.02482584
9Nucleotide excision repair_Homo sapiens_hsa034202.94726853
10Cell cycle_Homo sapiens_hsa041102.94283008
11One carbon pool by folate_Homo sapiens_hsa006702.87986090
12RNA polymerase_Homo sapiens_hsa030202.81263797
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.69250209
14Fanconi anemia pathway_Homo sapiens_hsa034602.59181511
15p53 signaling pathway_Homo sapiens_hsa041152.32408130
16Proteasome_Homo sapiens_hsa030502.30485730
17Pyrimidine metabolism_Homo sapiens_hsa002402.02117939
18mRNA surveillance pathway_Homo sapiens_hsa030151.95402693
19Basal transcription factors_Homo sapiens_hsa030221.92466758
20Non-homologous end-joining_Homo sapiens_hsa034501.92045997
21RNA degradation_Homo sapiens_hsa030181.90952200
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52779494
23Steroid biosynthesis_Homo sapiens_hsa001001.49069847
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41405410
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36710320
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35204490
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33657471
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32228685
29Basal cell carcinoma_Homo sapiens_hsa052171.26407107
30Systemic lupus erythematosus_Homo sapiens_hsa053221.25885134
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19598143
32Hippo signaling pathway_Homo sapiens_hsa043901.19390873
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16542475
34MicroRNAs in cancer_Homo sapiens_hsa052061.13776988
35Epstein-Barr virus infection_Homo sapiens_hsa051691.12020866
36Pyruvate metabolism_Homo sapiens_hsa006201.11878962
37Oocyte meiosis_Homo sapiens_hsa041141.10897463
38Viral carcinogenesis_Homo sapiens_hsa052031.06818056
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02533210
40Fatty acid elongation_Homo sapiens_hsa000621.00881545
41TGF-beta signaling pathway_Homo sapiens_hsa043500.99173702
42Purine metabolism_Homo sapiens_hsa002300.98229316
43Hedgehog signaling pathway_Homo sapiens_hsa043400.97569048
44Bladder cancer_Homo sapiens_hsa052190.94629441
45HTLV-I infection_Homo sapiens_hsa051660.93446418
46Parkinsons disease_Homo sapiens_hsa050120.92173047
47Small cell lung cancer_Homo sapiens_hsa052220.90845976
48Arginine and proline metabolism_Homo sapiens_hsa003300.88928954
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87651686
50Biosynthesis of amino acids_Homo sapiens_hsa012300.82817622
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82156006
52Herpes simplex infection_Homo sapiens_hsa051680.81282100
53Gap junction_Homo sapiens_hsa045400.75679300
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73247087
55Notch signaling pathway_Homo sapiens_hsa043300.71737593
56Thyroid cancer_Homo sapiens_hsa052160.70266244
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69781390
58Adherens junction_Homo sapiens_hsa045200.66795880
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65686880
60Selenocompound metabolism_Homo sapiens_hsa004500.65607078
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64068708
62Colorectal cancer_Homo sapiens_hsa052100.63656647
63Oxidative phosphorylation_Homo sapiens_hsa001900.62818444
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62726614
65Nicotine addiction_Homo sapiens_hsa050330.60824992
66Axon guidance_Homo sapiens_hsa043600.59602788
67Melanogenesis_Homo sapiens_hsa049160.58821401
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.57488158
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57071112
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.56969123
71Melanoma_Homo sapiens_hsa052180.56570496
72Pathways in cancer_Homo sapiens_hsa052000.54899119
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53400559
74Apoptosis_Homo sapiens_hsa042100.53279792
75Wnt signaling pathway_Homo sapiens_hsa043100.52501049
76Chronic myeloid leukemia_Homo sapiens_hsa052200.51446889
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51168886
78Alzheimers disease_Homo sapiens_hsa050100.51105420
79Tight junction_Homo sapiens_hsa045300.50981812
80Prion diseases_Homo sapiens_hsa050200.50050967
81Fructose and mannose metabolism_Homo sapiens_hsa000510.50044465
82Fatty acid metabolism_Homo sapiens_hsa012120.49350838
83Folate biosynthesis_Homo sapiens_hsa007900.49257342
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46708388
85N-Glycan biosynthesis_Homo sapiens_hsa005100.46101531
86Alcoholism_Homo sapiens_hsa050340.44949646
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.44646916
88mTOR signaling pathway_Homo sapiens_hsa041500.44281429
89Pentose phosphate pathway_Homo sapiens_hsa000300.44020530
90Glioma_Homo sapiens_hsa052140.43754591
91HIF-1 signaling pathway_Homo sapiens_hsa040660.42751550
92Antigen processing and presentation_Homo sapiens_hsa046120.41349907
93Proteoglycans in cancer_Homo sapiens_hsa052050.40212802
94Synaptic vesicle cycle_Homo sapiens_hsa047210.39992291
95Glutathione metabolism_Homo sapiens_hsa004800.38521460
96Legionellosis_Homo sapiens_hsa051340.37786895
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37460903
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36954934
99Prostate cancer_Homo sapiens_hsa052150.35991974
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35743359
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34804414
102Shigellosis_Homo sapiens_hsa051310.33347092
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32276861
104ErbB signaling pathway_Homo sapiens_hsa040120.31920705
105GABAergic synapse_Homo sapiens_hsa047270.31678465
106Dopaminergic synapse_Homo sapiens_hsa047280.31606963
107Protein export_Homo sapiens_hsa030600.31585306
108Hepatitis B_Homo sapiens_hsa051610.31224522
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.31022462
110Cardiac muscle contraction_Homo sapiens_hsa042600.30631269
111Cocaine addiction_Homo sapiens_hsa050300.30593252
112Sulfur relay system_Homo sapiens_hsa041220.29756516
113ECM-receptor interaction_Homo sapiens_hsa045120.29204333
114Amphetamine addiction_Homo sapiens_hsa050310.28938046
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27617449
116Huntingtons disease_Homo sapiens_hsa050160.25537600
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24953654
118Carbon metabolism_Homo sapiens_hsa012000.24455168
119Endometrial cancer_Homo sapiens_hsa052130.24256322
120Galactose metabolism_Homo sapiens_hsa000520.23931213
121Acute myeloid leukemia_Homo sapiens_hsa052210.23644064
122FoxO signaling pathway_Homo sapiens_hsa040680.20097445
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.17816810
124Non-small cell lung cancer_Homo sapiens_hsa052230.17624766
125Lysine degradation_Homo sapiens_hsa003100.17374864
126Vitamin B6 metabolism_Homo sapiens_hsa007500.16962103
127Pancreatic cancer_Homo sapiens_hsa052120.16706814
128Viral myocarditis_Homo sapiens_hsa054160.16627704
129Focal adhesion_Homo sapiens_hsa045100.15527122
130Measles_Homo sapiens_hsa051620.14370937
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14117917
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12425223
133Influenza A_Homo sapiens_hsa051640.12088739
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12008587
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11616448
136Arachidonic acid metabolism_Homo sapiens_hsa005900.09713197
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.09698886

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