PTAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.16749176
2negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.10365804
3negative regulation of DNA-templated transcription, elongation (GO:0032785)5.10365804
4pre-miRNA processing (GO:0031054)5.02636819
5nuclear pore organization (GO:0006999)4.75700954
6CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.71171776
7negative regulation of osteoblast proliferation (GO:0033689)4.45337476
8lung epithelium development (GO:0060428)4.40185147
9negative regulation of DNA repair (GO:0045738)4.39618034
10cell proliferation involved in metanephros development (GO:0072203)4.37224137
11regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.32895184
12monoubiquitinated protein deubiquitination (GO:0035520)4.27750162
13embryonic foregut morphogenesis (GO:0048617)4.25923028
14cytoplasmic mRNA processing body assembly (GO:0033962)4.14808961
15pore complex assembly (GO:0046931)4.06807875
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.01309160
17astrocyte differentiation (GO:0048708)3.98741172
18paraxial mesoderm development (GO:0048339)3.96785804
19lung lobe morphogenesis (GO:0060463)3.96596399
20dopaminergic neuron differentiation (GO:0071542)3.87544909
21substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.80869138
22substrate-independent telencephalic tangential migration (GO:0021826)3.80869138
23midbrain development (GO:0030901)3.78535681
24T cell lineage commitment (GO:0002360)3.73313895
25regulation of RNA export from nucleus (GO:0046831)3.72999580
26DNA strand elongation involved in DNA replication (GO:0006271)3.67780513
27negative regulation of alpha-beta T cell differentiation (GO:0046639)3.67172464
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.63340186
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.63340186
30regulation of translation, ncRNA-mediated (GO:0045974)3.63340186
31negative regulation of smooth muscle cell differentiation (GO:0051151)3.62380010
32embryonic process involved in female pregnancy (GO:0060136)3.62169519
33translesion synthesis (GO:0019985)3.60619652
34histone H3-K36 demethylation (GO:0070544)3.60255820
35mitotic sister chromatid cohesion (GO:0007064)3.56383611
36regulation of histone H3-K9 methylation (GO:0051570)3.54201475
37DNA strand elongation (GO:0022616)3.52326275
38negative regulation of fibroblast apoptotic process (GO:2000270)3.47635707
39mitotic nuclear envelope disassembly (GO:0007077)3.47344521
40sperm-egg recognition (GO:0035036)3.46573021
41binding of sperm to zona pellucida (GO:0007339)3.44778446
42epithelial cilium movement (GO:0003351)3.40961989
43kinetochore organization (GO:0051383)3.40770382
44artery development (GO:0060840)3.37523664
45positive regulation of oligodendrocyte differentiation (GO:0048714)3.37518292
46DNA unwinding involved in DNA replication (GO:0006268)3.36952085
47telomere maintenance via semi-conservative replication (GO:0032201)3.36804497
48negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.35234995
49CENP-A containing nucleosome assembly (GO:0034080)3.34917448
50somite development (GO:0061053)3.34263609
51interkinetic nuclear migration (GO:0022027)3.27856753
52regulation of posttranscriptional gene silencing (GO:0060147)3.26919085
53regulation of gene silencing by miRNA (GO:0060964)3.26919085
54regulation of gene silencing by RNA (GO:0060966)3.26919085
55positive thymic T cell selection (GO:0045059)3.22575035
56embryonic camera-type eye morphogenesis (GO:0048596)3.22267526
57positive regulation of SMAD protein import into nucleus (GO:0060391)3.20257960
58histone H3-K9 demethylation (GO:0033169)3.19248035
59membrane disassembly (GO:0030397)3.18408418
60nuclear envelope disassembly (GO:0051081)3.18408418
61genitalia morphogenesis (GO:0035112)3.18221687
62dorsal/ventral axis specification (GO:0009950)3.17676340
63histone-serine phosphorylation (GO:0035404)3.17414090
64definitive hemopoiesis (GO:0060216)3.16139867
65protein polyglutamylation (GO:0018095)3.16037047
66kinetochore assembly (GO:0051382)3.14243445
67chromatin remodeling at centromere (GO:0031055)3.14134729
68lymphoid progenitor cell differentiation (GO:0002320)3.13158735
69histone exchange (GO:0043486)3.11774100
70positive regulation of cell cycle checkpoint (GO:1901978)3.11755696
71DNA replication initiation (GO:0006270)3.11475327
72nucleus localization (GO:0051647)3.10269981
73regulation of nucleobase-containing compound transport (GO:0032239)3.08094645
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07482454
75regulation of mesenchymal cell apoptotic process (GO:2001053)3.07216160
76NLS-bearing protein import into nucleus (GO:0006607)3.06578583
77mesenchymal cell proliferation (GO:0010463)3.06517845
78lung-associated mesenchyme development (GO:0060484)3.05300680
79postreplication repair (GO:0006301)3.04891743
80cilium or flagellum-dependent cell motility (GO:0001539)3.04812330
81DNA replication-independent nucleosome assembly (GO:0006336)3.03146284
82DNA replication-independent nucleosome organization (GO:0034724)3.03146284
83fusion of sperm to egg plasma membrane (GO:0007342)3.01722050
84mitotic metaphase plate congression (GO:0007080)3.01045974
85establishment of nucleus localization (GO:0040023)2.99420391
86ribosome assembly (GO:0042255)2.99271702
87morphogenesis of an epithelial sheet (GO:0002011)2.98849165
88telomere maintenance via recombination (GO:0000722)2.98246581
89cell-cell recognition (GO:0009988)2.97899141
90metaphase plate congression (GO:0051310)2.97340564
91negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.96913320
92positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.94246246
93cell proliferation involved in kidney development (GO:0072111)2.91036470
94motile cilium assembly (GO:0044458)2.90551872
95negative regulation of proteasomal protein catabolic process (GO:1901799)2.90323792
96negative regulation of cell aging (GO:0090344)2.90101527
97limb bud formation (GO:0060174)2.89843772
98protein localization to chromosome, centromeric region (GO:0071459)2.87613157
99regulation of transforming growth factor beta2 production (GO:0032909)2.87476953
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86363843
101purine nucleobase biosynthetic process (GO:0009113)2.83759805
102histone H2A acetylation (GO:0043968)2.83574348
103gastrulation with mouth forming second (GO:0001702)2.82946082
104microtubule depolymerization (GO:0007019)2.82615076
105DNA deamination (GO:0045006)2.82083609
106negative regulation of histone methylation (GO:0031061)2.79687028
107histone lysine demethylation (GO:0070076)2.79223605
108regulation of DNA endoreduplication (GO:0032875)2.79188307
109mitotic chromosome condensation (GO:0007076)2.79107629
110regulation of sister chromatid cohesion (GO:0007063)2.78680145
111DNA duplex unwinding (GO:0032508)2.78324849
112notochord development (GO:0030903)2.78257331
113mitotic recombination (GO:0006312)2.75598869
114negative regulation of proteolysis involved in cellular protein catabolic process (GO:1903051)2.75204473
115DNA geometric change (GO:0032392)2.75095323
116regulation of spindle organization (GO:0090224)2.74911142
117positive regulation of catenin import into nucleus (GO:0035413)2.71719397
118negative regulation of cellular protein catabolic process (GO:1903363)2.71270435
119regulation of centrosome duplication (GO:0010824)2.70458233
120branching involved in salivary gland morphogenesis (GO:0060445)2.70281062
121regulation of mesoderm development (GO:2000380)2.69447613
122axon ensheathment in central nervous system (GO:0032291)2.68693518
123central nervous system myelination (GO:0022010)2.68693518
124regulation of translational termination (GO:0006449)2.68264344
125acrosome reaction (GO:0007340)2.68039602
126protein localization to kinetochore (GO:0034501)2.67961930
127regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.67406723
128nucleobase biosynthetic process (GO:0046112)2.67132692
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.65885778
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65885778
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65885778
132negative regulation of sister chromatid segregation (GO:0033046)2.65885778
133regulation of gene silencing (GO:0060968)2.65452847
134acrosome assembly (GO:0001675)2.65119073
135regulation of DNA damage checkpoint (GO:2000001)2.63226711
136sodium ion export (GO:0071436)2.63140307
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62872362
138regulation of mitotic spindle checkpoint (GO:1903504)2.62872362
139regulation of centriole replication (GO:0046599)2.61980967
140axonemal dynein complex assembly (GO:0070286)2.61375199
141microtubule anchoring (GO:0034453)2.61160389
142embryonic retina morphogenesis in camera-type eye (GO:0060059)2.60261372
143negative regulation of chromosome segregation (GO:0051985)2.59400925
144sister chromatid segregation (GO:0000819)2.59159238
145nucleotide-excision repair, DNA gap filling (GO:0006297)2.59120674
146negative regulation of alpha-beta T cell activation (GO:0046636)2.58867381
147IMP biosynthetic process (GO:0006188)2.58579213
148histone demethylation (GO:0016577)2.58553006
149cartilage morphogenesis (GO:0060536)2.58148562
150DNA replication-dependent nucleosome organization (GO:0034723)2.58115760
151DNA replication-dependent nucleosome assembly (GO:0006335)2.58115760
152positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58019445
153positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.58019445
154positive regulation of mitotic sister chromatid separation (GO:1901970)2.58019445
155sister chromatid cohesion (GO:0007062)2.55119071
156regulation of NFAT protein import into nucleus (GO:0051532)2.54816092
157mitotic G2 DNA damage checkpoint (GO:0007095)2.54653372
158regulation of histone H3-K27 methylation (GO:0061085)2.54530112
159centrosome localization (GO:0051642)2.53829541
160dosage compensation (GO:0007549)2.52908207
161radial glial cell differentiation (GO:0060019)2.52583430
162cellular response to ethanol (GO:0071361)2.51715747
163regulation of chromatin silencing (GO:0031935)2.47060721
164regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.44953888
165lipid translocation (GO:0034204)2.44844056
166phospholipid translocation (GO:0045332)2.44844056
167hippo signaling (GO:0035329)2.43412705
168double-strand break repair via nonhomologous end joining (GO:0006303)2.42550235
169non-recombinational repair (GO:0000726)2.42550235
170organ growth (GO:0035265)2.42037277
171regulation of pigment cell differentiation (GO:0050932)2.42033109
172peptidyl-threonine phosphorylation (GO:0018107)2.41689696
173nucleus organization (GO:0006997)2.41324848
174mRNA stabilization (GO:0048255)2.38546201
175RNA stabilization (GO:0043489)2.38546201
176mitotic G2/M transition checkpoint (GO:0044818)2.38043056
177coronary vasculature morphogenesis (GO:0060977)2.37901554
178positive regulation of developmental pigmentation (GO:0048087)2.37856148
179negative regulation of neurotransmitter secretion (GO:0046929)2.37584119
180embryonic eye morphogenesis (GO:0048048)2.37410235
181histone H3-K9 methylation (GO:0051567)2.35925231
182heterochromatin organization (GO:0070828)2.35377087
183regulation of centrosome cycle (GO:0046605)2.35300550
184SMAD protein complex assembly (GO:0007183)2.34710938
185peptidyl-threonine modification (GO:0018210)2.34551332
186regulation of mitotic sister chromatid separation (GO:0010965)2.34004557
187regulation of mitotic sister chromatid segregation (GO:0033047)2.34004557
188regulation of sister chromatid segregation (GO:0033045)2.34004557
189regulation of Rac protein signal transduction (GO:0035020)2.33453417
190DNA topological change (GO:0006265)2.32251789
191labyrinthine layer development (GO:0060711)2.31917865

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.89357688
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.42781571
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.19862843
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.34546130
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.30428694
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.97918874
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28468400
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.17043975
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.13134389
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.07824542
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.84054953
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83572037
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81053919
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.78203551
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.65735802
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63013013
17XRN2_22483619_ChIP-Seq_HELA_Human2.60079956
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50744352
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.50227494
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36909865
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.35031931
22AR_21909140_ChIP-Seq_LNCAP_Human2.34634540
23GATA1_22025678_ChIP-Seq_K562_Human2.33539156
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29614634
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29353297
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24047161
27WT1_19549856_ChIP-ChIP_CCG9911_Human2.23169944
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.22397329
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22034314
30POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19967631
31TTF2_22483619_ChIP-Seq_HELA_Human2.13223333
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09260310
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02853401
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.02224098
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98066539
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.97107247
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.92239036
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92165174
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.91910266
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88861851
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86792737
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85123600
43VDR_23849224_ChIP-Seq_CD4+_Human1.83111633
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82360383
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82221871
46FOXP3_21729870_ChIP-Seq_TREG_Human1.77791104
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.77614890
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.74141437
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74010235
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.73502715
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72306420
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69483516
53TAF15_26573619_Chip-Seq_HEK293_Human1.69036460
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65384659
55SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.65237190
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.63753093
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.63753093
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.63753093
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62609298
60ELK1_19687146_ChIP-ChIP_HELA_Human1.61906406
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60432366
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.59726594
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59687609
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59612637
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56988368
66DCP1A_22483619_ChIP-Seq_HELA_Human1.56826172
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54954039
68GBX2_23144817_ChIP-Seq_PC3_Human1.54893621
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51757604
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51028658
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50890703
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49214779
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.48591785
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46671367
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.44835826
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44520087
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44235494
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43901011
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42778015
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40815431
81TP53_16413492_ChIP-PET_HCT116_Human1.38358533
82* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38106696
83MYC_22102868_ChIP-Seq_BL_Human1.37063159
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36822011
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.36199355
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35773677
87CIITA_25753668_ChIP-Seq_RAJI_Human1.34429149
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34273367
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34135823
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33003646
91P300_19829295_ChIP-Seq_ESCs_Human1.31354008
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.30980683
93GABP_19822575_ChIP-Seq_HepG2_Human1.30787586
94FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30710276
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29692915
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.29002008
97TBX3_20139965_ChIP-Seq_MESCs_Mouse1.28599022
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28074217
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28074217
100SMAD4_21799915_ChIP-Seq_A2780_Human1.26269884
101BRD4_25478319_ChIP-Seq_HGPS_Human1.25138958
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.25031353
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24528370
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24184071
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23945246
106* STAT3_23295773_ChIP-Seq_U87_Human1.20349788
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20286805
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19584889
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17712506
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17589104
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17472145
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17136259
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.16057338
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16021668
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15504652
116TCF4_18268006_ChIP-ChIP_LS174T_Human1.14880195
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14778068
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13977404
119ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13662857
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.13422819
121AR_21572438_ChIP-Seq_LNCaP_Human1.12115780
122ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11310154
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10979302
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.09188030
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08954560
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07559264
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.07429133
128MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07354914
129HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06506760
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06477429
131ISL1_27105846_Chip-Seq_CPCs_Mouse1.04628042
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04356324
133SRF_21415370_ChIP-Seq_HL-1_Mouse1.03931015
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03149465
135FOXO3_23340844_ChIP-Seq_DLD1_Human1.02676544
136* SOX9_26525672_Chip-Seq_HEART_Mouse1.01993740
137PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01963701
138FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01707873
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01003847
140SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00717657
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99880317
142KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99659551
143PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99376864
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98691738
145ELK1_22589737_ChIP-Seq_MCF10A_Human0.98680971
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97889386
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97889386
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96507282
149SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96445767
150TCF4_23295773_ChIP-Seq_U87_Human0.96419124
151TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96281674
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95908179
153NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95260130
154STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95249796
155MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93848774
156ARNT_22903824_ChIP-Seq_MCF-7_Human0.92978770
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.92194922
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92079734
159TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91809029
160TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91767701
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91756985
162CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89763482
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88228149
164SOX2_16153702_ChIP-ChIP_HESCs_Human0.87415662
165ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87410746
166MYB_26560356_Chip-Seq_TH2_Human0.86261155
167SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85147828
168CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.82935111
169TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80231519
170NANOG_16153702_ChIP-ChIP_HESCs_Human0.80155011
171TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76162359
172RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.75445353
173DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74335188
174CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.73069398
175SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.70263641
176FUS_26573619_Chip-Seq_HEK293_Human0.66989295
177PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.65844425
178EWS_26573619_Chip-Seq_HEK293_Human0.63519269
179PKCTHETA_26484144_Chip-Seq_BREAST_Human0.60579723
180ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.60440240
181SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.59626014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.13744621
2MP0002009_preneoplasia4.60051090
3MP0002102_abnormal_ear_morphology4.02003434
4MP0002234_abnormal_pharynx_morphology3.93533235
5MP0003183_abnormal_peptide_metabolism3.51615806
6MP0000569_abnormal_digit_pigmentation3.41864571
7MP0010094_abnormal_chromosome_stability3.00783562
8MP0002653_abnormal_ependyma_morphology2.83790991
9MP0005423_abnormal_somatic_nervous2.62958951
10MP0003693_abnormal_embryo_hatching2.51829026
11MP0005503_abnormal_tendon_morphology2.51006590
12MP0003111_abnormal_nucleus_morphology2.42215194
13MP0010030_abnormal_orbit_morphology2.37041058
14MP0008995_early_reproductive_senescence2.32720856
15MP0002282_abnormal_trachea_morphology2.28961271
16MP0009053_abnormal_anal_canal2.26026893
17MP0009384_cardiac_valve_regurgitation2.20365542
18MP0008057_abnormal_DNA_replication2.12052923
19MP0003941_abnormal_skin_development2.08094827
20MP0003077_abnormal_cell_cycle2.02892119
21MP0000383_abnormal_hair_follicle1.99998054
22MP0008961_abnormal_basal_metabolism1.97560214
23MP0006054_spinal_hemorrhage1.91785671
24MP0003705_abnormal_hypodermis_morpholog1.87051781
25MP0005410_abnormal_fertilization1.85212019
26MP0001293_anophthalmia1.79398845
27MP0005248_abnormal_Harderian_gland1.77786115
28MP0008007_abnormal_cellular_replicative1.74493062
29MP0003091_abnormal_cell_migration1.74342117
30MP0002751_abnormal_autonomic_nervous1.73249246
31MP0008058_abnormal_DNA_repair1.67807411
32MP0003567_abnormal_fetal_cardiomyocyte1.66586399
33MP0004957_abnormal_blastocyst_morpholog1.64511703
34MP0001661_extended_life_span1.62400701
35MP0000566_synostosis1.60770548
36MP0003786_premature_aging1.60736563
37MP0002166_altered_tumor_susceptibility1.60322210
38MP0002932_abnormal_joint_morphology1.57835211
39MP0004272_abnormal_basement_membrane1.54906164
40MP0002086_abnormal_extraembryonic_tissu1.52176971
41MP0000428_abnormal_craniofacial_morphol1.51955488
42MP0009703_decreased_birth_body1.49997994
43MP0010234_abnormal_vibrissa_follicle1.48107244
44MP0000631_abnormal_neuroendocrine_gland1.45924775
45MP0008877_abnormal_DNA_methylation1.44366882
46MP0003300_gastrointestinal_ulcer1.43181826
47MP0003122_maternal_imprinting1.41115882
48MP0004808_abnormal_hematopoietic_stem1.37823192
49MP0010352_gastrointestinal_tract_polyps1.35519399
50MP0010307_abnormal_tumor_latency1.32993634
51MP0003115_abnormal_respiratory_system1.32885149
52MP0001929_abnormal_gametogenesis1.32270647
53MP0003121_genomic_imprinting1.32182574
54MP0000462_abnormal_digestive_system1.32036476
55MP0002877_abnormal_melanocyte_morpholog1.31859407
56MP0009697_abnormal_copulation1.31498783
57MP0009672_abnormal_birth_weight1.29834129
58MP0001299_abnormal_eye_distance/1.28378791
59MP0000537_abnormal_urethra_morphology1.23592822
60MP0008932_abnormal_embryonic_tissue1.22459323
61MP0003828_pulmonary_edema1.22269317
62MP0004185_abnormal_adipocyte_glucose1.20310707
63MP0002092_abnormal_eye_morphology1.19446457
64MP0003221_abnormal_cardiomyocyte_apopto1.18198350
65MP0002006_tumorigenesis1.16423430
66MP0001177_atelectasis1.16075911
67MP0005187_abnormal_penis_morphology1.14792658
68MP0000350_abnormal_cell_proliferation1.14056850
69MP0002925_abnormal_cardiovascular_devel1.12069952
70MP0002210_abnormal_sex_determination1.11645841
71MP0002233_abnormal_nose_morphology1.11510909
72MP0003943_abnormal_hepatobiliary_system1.11476416
73MP0002084_abnormal_developmental_patter1.10816176
74MP0003950_abnormal_plasma_membrane1.07043651
75MP0010678_abnormal_skin_adnexa1.06529529
76MP0003698_abnormal_male_reproductive1.05897450
77MP0003385_abnormal_body_wall1.05364666
78MP0001145_abnormal_male_reproductive1.04284949
79MP0003938_abnormal_ear_development1.04057769
80MP0002116_abnormal_craniofacial_bone1.03401848
81MP0004134_abnormal_chest_morphology1.02649604
82MP0000778_abnormal_nervous_system1.00893925
83MP0003984_embryonic_growth_retardation0.99943867
84MP0004197_abnormal_fetal_growth/weight/0.99937293
85MP0005508_abnormal_skeleton_morphology0.98570491
86MP0003656_abnormal_erythrocyte_physiolo0.98196141
87MP0003566_abnormal_cell_adhesion0.98022655
88MP0010630_abnormal_cardiac_muscle0.97439068
89MP0001672_abnormal_embryogenesis/_devel0.97405084
90MP0005380_embryogenesis_phenotype0.97405084
91MP0002085_abnormal_embryonic_tissue0.97175810
92MP0002088_abnormal_embryonic_growth/wei0.97072953
93MP0005391_vision/eye_phenotype0.96765892
94MP0003942_abnormal_urinary_system0.96629406
95MP0001851_eye_inflammation0.95838506
96MP0001286_abnormal_eye_development0.95743310
97MP0001730_embryonic_growth_arrest0.95628850
98MP0003937_abnormal_limbs/digits/tail_de0.95101000
99MP0003763_abnormal_thymus_physiology0.94057240
100MP0002163_abnormal_gland_morphology0.93599646
101MP0005621_abnormal_cell_physiology0.92574965
102MP0000465_gastrointestinal_hemorrhage0.91610587
103MP0003890_abnormal_embryonic-extraembry0.89353632
104MP0002396_abnormal_hematopoietic_system0.89148579
105MP0002113_abnormal_skeleton_development0.88964155
106MP0000313_abnormal_cell_death0.88331843
107MP0003119_abnormal_digestive_system0.87975628
108MP0004381_abnormal_hair_follicle0.87742242
109MP0001879_abnormal_lymphatic_vessel0.87674948
110MP0003868_abnormal_feces_composition0.87618252
111MP0003315_abnormal_perineum_morphology0.85509161
112MP0000653_abnormal_sex_gland0.85005045
113MP0001784_abnormal_fluid_regulation0.83811878
114MP0002938_white_spotting0.83768058
115MP0000703_abnormal_thymus_morphology0.82327811
116MP0002697_abnormal_eye_size0.81462857
117MP0000163_abnormal_cartilage_morphology0.81225358
118MP0005076_abnormal_cell_differentiation0.80183292
119MP0002128_abnormal_blood_circulation0.79666434
120MP0006138_congestive_heart_failure0.79533280
121MP0002133_abnormal_respiratory_system0.78403272
122MP0005388_respiratory_system_phenotype0.78403272
123MP0001697_abnormal_embryo_size0.77589619
124MP0003172_abnormal_lysosome_physiology0.76762199
125MP0000432_abnormal_head_morphology0.75282753
126MP0000427_abnormal_hair_cycle0.74949280
127MP0000767_abnormal_smooth_muscle0.74812577
128MP0003136_yellow_coat_color0.74751628
129MP0000266_abnormal_heart_morphology0.74726607
130MP0003755_abnormal_palate_morphology0.74485376
131MP0002080_prenatal_lethality0.74242227
132MP0001175_abnormal_lung_morphology0.73860341
133MP0002111_abnormal_tail_morphology0.72899326
134MP0003935_abnormal_craniofacial_develop0.72619600
135MP0000371_diluted_coat_color0.72351899
136MP0000490_abnormal_crypts_of0.72327602
137MP0001915_intracranial_hemorrhage0.70845955
138MP0001243_abnormal_dermal_layer0.70529834
139MP0000534_abnormal_ureter_morphology0.70277690
140MP0001340_abnormal_eyelid_morphology0.69984716
141MP0001958_emphysema0.69331509
142MP0005409_darkened_coat_color0.69216335
143MP0002161_abnormal_fertility/fecundity0.68468950
144MP0005220_abnormal_exocrine_pancreas0.67502829
145MP0002109_abnormal_limb_morphology0.67204624
146MP0003861_abnormal_nervous_system0.67091679
147MP0001529_abnormal_vocalization0.66448350
148MP0009250_abnormal_appendicular_skeleto0.64718206
149MP0005646_abnormal_pituitary_gland0.64584187
150MP0000467_abnormal_esophagus_morphology0.62736877
151MP0000733_abnormal_muscle_development0.62470112

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.41332382
2Papillary thyroid carcinoma (HP:0002895)4.26950919
3Abnormal number of incisors (HP:0011064)4.25090056
4Absent/shortened dynein arms (HP:0200106)3.71234494
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.71234494
6Hepatoblastoma (HP:0002884)3.46956138
7Concave nail (HP:0001598)3.37470859
8Bilateral microphthalmos (HP:0007633)3.20382952
9Nephroblastoma (Wilms tumor) (HP:0002667)3.14848856
10Rhinitis (HP:0012384)3.13420121
11Aplasia of the musculature (HP:0100854)3.12652053
12Subacute progressive viral hepatitis (HP:0006572)3.11892585
13Embryonal renal neoplasm (HP:0011794)3.01994177
14Short middle phalanx of the 5th finger (HP:0004220)2.99618696
15Vertebral arch anomaly (HP:0008438)2.97689796
16Renal duplication (HP:0000075)2.93157962
17Increased corneal curvature (HP:0100692)2.85108478
18Keratoconus (HP:0000563)2.85108478
19Thyroid carcinoma (HP:0002890)2.78590958
20Amaurosis fugax (HP:0100576)2.77788211
21Acute myeloid leukemia (HP:0004808)2.77698476
22Abnormal respiratory motile cilium morphology (HP:0005938)2.74912455
23Abnormal respiratory epithelium morphology (HP:0012253)2.74912455
24Anophthalmia (HP:0000528)2.68487402
25Vitreoretinal degeneration (HP:0000655)2.66129143
26Abnormal respiratory motile cilium physiology (HP:0012261)2.64522571
27Overgrowth (HP:0001548)2.61099506
28Syringomyelia (HP:0003396)2.59131609
29Spinal cord lesions (HP:0100561)2.59131609
30True hermaphroditism (HP:0010459)2.52472075
31Volvulus (HP:0002580)2.51852640
32Transitional cell carcinoma of the bladder (HP:0006740)2.50673352
33Abnormality of the right ventricle (HP:0001707)2.43845065
34Malignant gastrointestinal tract tumors (HP:0006749)2.42451145
35Gastrointestinal carcinoma (HP:0002672)2.42451145
36Large earlobe (HP:0009748)2.41001063
37Medulloblastoma (HP:0002885)2.38876797
38Maternal diabetes (HP:0009800)2.37728933
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.37298837
40Birth length less than 3rd percentile (HP:0003561)2.36945319
41Growth hormone deficiency (HP:0000824)2.35371003
42Deep philtrum (HP:0002002)2.35288624
43Bladder carcinoma (HP:0002862)2.34529501
44Bladder neoplasm (HP:0009725)2.34529501
45Patellar dislocation (HP:0002999)2.32674356
46Flat cornea (HP:0007720)2.32607233
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31292689
48Aqueductal stenosis (HP:0002410)2.30595722
49Chronic bronchitis (HP:0004469)2.29761613
5011 pairs of ribs (HP:0000878)2.25476978
51Asymmetry of the thorax (HP:0001555)2.25238253
52Rhabdomyosarcoma (HP:0002859)2.25110713
53Heterotopia (HP:0002282)2.23389252
54Chromsome breakage (HP:0040012)2.22742128
55Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.21865980
56Aplasia/Hypoplasia involving the musculature (HP:0001460)2.20810815
57Abnormality of the fingertips (HP:0001211)2.20027996
58Aplasia cutis congenita (HP:0001057)2.19549997
59Renovascular hypertension (HP:0100817)2.19522901
60Germ cell neoplasia (HP:0100728)2.17902400
61Sandal gap (HP:0001852)2.17760881
62Tented upper lip vermilion (HP:0010804)2.17539668
63Narrow palate (HP:0000189)2.16753900
64Neoplasm of the small intestine (HP:0100833)2.15414462
65Leiomyosarcoma (HP:0100243)2.14284137
66Uterine leiomyosarcoma (HP:0002891)2.14284137
67Toxemia of pregnancy (HP:0100603)2.13309780
68Carpal bone hypoplasia (HP:0001498)2.11858902
69Ectopic kidney (HP:0000086)2.10652835
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.10567290
71Small intestinal stenosis (HP:0012848)2.10372013
72Duodenal stenosis (HP:0100867)2.10372013
73Overriding aorta (HP:0002623)2.10345471
74Increased nuchal translucency (HP:0010880)2.08311386
75Long eyelashes (HP:0000527)2.07568999
76Limited elbow extension (HP:0001377)2.07559615
77Short 4th metacarpal (HP:0010044)2.06084167
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06084167
79Elfin facies (HP:0004428)2.05337213
80Bowel diverticulosis (HP:0005222)2.04081166
81Abnormality of the incisor (HP:0000676)2.03037574
82Abnormal ciliary motility (HP:0012262)2.01014977
83Hyperacusis (HP:0010780)2.00793044
84T lymphocytopenia (HP:0005403)2.00427738
85Decreased skull ossification (HP:0004331)1.99816562
86Convex nasal ridge (HP:0000444)1.98585248
87Hypoplastic labia majora (HP:0000059)1.98302117
88Triphalangeal thumb (HP:0001199)1.98168293
89Patellar aplasia (HP:0006443)1.97949518
90Arterial tortuosity (HP:0005116)1.97428756
91Abnormality of the duodenum (HP:0002246)1.97241000
92Spondylolisthesis (HP:0003302)1.96633908
93Embryonal neoplasm (HP:0002898)1.96488351
94Neonatal hypoglycemia (HP:0001998)1.96035717
95Abnormality of the radial head (HP:0003995)1.95960948
96Absent frontal sinuses (HP:0002688)1.94180984
97Abnormal sex determination (HP:0012244)1.91930170
98Sex reversal (HP:0012245)1.91930170
99Relative macrocephaly (HP:0004482)1.90987676
100Flat capital femoral epiphysis (HP:0003370)1.90816572
101Cubitus valgus (HP:0002967)1.89308114
102Short 5th finger (HP:0009237)1.88866669
103Low anterior hairline (HP:0000294)1.88263492
104Subaortic stenosis (HP:0001682)1.87496120
105Abnormality of the left ventricular outflow tract (HP:0011103)1.87496120
106Prominent nose (HP:0000448)1.86953509
107Ankyloglossia (HP:0010296)1.86712549
108Missing ribs (HP:0000921)1.85949160
109Colon cancer (HP:0003003)1.85935943
110Cystic hygroma (HP:0000476)1.85449766
111Short ribs (HP:0000773)1.84930436
112Pulmonic stenosis (HP:0001642)1.84867947
113Biliary tract neoplasm (HP:0100574)1.84648656
114Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.84606985
115Impulsivity (HP:0100710)1.82832947
116Wide nose (HP:0000445)1.81076688
117Broad palm (HP:0001169)1.80919669
118Abnormality of chromosome stability (HP:0003220)1.80167876
119Viral hepatitis (HP:0006562)1.79873192
120Mitral valve prolapse (HP:0001634)1.79779535
121Truncal obesity (HP:0001956)1.79395215
122Congenital stationary night blindness (HP:0007642)1.79255406
123Dislocated radial head (HP:0003083)1.78971600
124Abnormal vertebral ossification (HP:0100569)1.78503790
125High anterior hairline (HP:0009890)1.78490733
126Abnormality of the intervertebral disk (HP:0005108)1.78368622
127Nasal polyposis (HP:0100582)1.77693315
128Hypoplasia of the maxilla (HP:0000327)1.77050928
129Ridged nail (HP:0001807)1.76762288
130Neoplasm of striated muscle (HP:0009728)1.74220881
131Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.73814307
132Preaxial hand polydactyly (HP:0001177)1.73434970
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73050446
134Metaphyseal cupping (HP:0003021)1.73001294
135Microretrognathia (HP:0000308)1.72760391
136Broad ribs (HP:0000885)1.72177740
137Septo-optic dysplasia (HP:0100842)1.71842191
138Midline defect of the nose (HP:0004122)1.71788570
139Broad phalanges of the hand (HP:0009768)1.71717579
140Neoplasm of the oral cavity (HP:0100649)1.71249204
141Abnormality of the distal phalanx of the thumb (HP:0009617)1.70818257
142Abnormality of the upper arm (HP:0001454)1.70551856
143Difficulty running (HP:0009046)1.70539296
144Protrusio acetabuli (HP:0003179)1.70138383
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69703762
146Abnormality of the nasal septum (HP:0000419)1.69438893
147Omphalocele (HP:0001539)1.69345854
148Abnormality of the ischium (HP:0003174)1.69307747
149Neoplasm of the adrenal cortex (HP:0100641)1.68609705
150Abnormal lung lobation (HP:0002101)1.68133645
151Abnormality of the labia majora (HP:0012881)1.68042276
1522-3 toe syndactyly (HP:0004691)1.68009890
153Bronchitis (HP:0012387)1.67787000
154Aortic aneurysm (HP:0004942)1.67081983
155Cerebellar dysplasia (HP:0007033)1.66412993
156Aplasia/Hypoplasia of the patella (HP:0006498)1.66329605
157Abnormality of the columella (HP:0009929)1.66267905
158Reticulocytopenia (HP:0001896)1.66049851
159Curly hair (HP:0002212)1.65542601
160Abnormality of the epiphyses of the hand (HP:0005924)1.65142319
161Vascular tortuosity (HP:0004948)1.64978764
162Obsessive-compulsive behavior (HP:0000722)1.64834036
163Abnormality of chromosome segregation (HP:0002916)1.64728405
164Premature graying of hair (HP:0002216)1.64258221
165Abnormality of the fibula (HP:0002991)1.64225193
166Spastic diplegia (HP:0001264)1.64222993
167Arnold-Chiari malformation (HP:0002308)1.64134261
168Broad phalanx (HP:0006009)1.63881439
169Selective tooth agenesis (HP:0001592)1.63371729
170Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.63291474
171Macroorchidism (HP:0000053)1.63237741
172Conjunctival telangiectasia (HP:0000524)1.63115838
173Intestinal atresia (HP:0011100)1.62970012
174Abnormality of skull ossification (HP:0002703)1.62685098
175Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62185319
176Absent epiphyses (HP:0010577)1.62185319
177Anal stenosis (HP:0002025)1.60992521
178Coronal craniosynostosis (HP:0004440)1.60419277
179Rough bone trabeculation (HP:0100670)1.60376801
180Aplastic anemia (HP:0001915)1.60276062
181Osteomalacia (HP:0002749)1.59739541
182Dysmetric saccades (HP:0000641)1.59555781
183Scanning speech (HP:0002168)1.59279922
184Aplasia/Hypoplasia of the tongue (HP:0010295)1.59215613
185Thickened helices (HP:0000391)1.58994737
186Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.58749345
187Aplasia/Hypoplasia of the lens (HP:0008063)1.58069692
188Cafe-au-lait spot (HP:0000957)1.57642713
189Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.56795884
190Hemangiomatosis (HP:0007461)1.56307582
191Abnormality of T cell number (HP:0011839)1.54141483
192Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.52665265
193Skull defect (HP:0001362)1.52123753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA36.37036581
2ACVR1B3.78925969
3BUB13.30963450
4WEE12.58376589
5DYRK32.49247660
6LATS12.48419047
7KSR12.42059671
8FGFR22.41737721
9CCNB12.38799155
10BRD42.32935089
11CDK122.21587830
12NEK12.18238528
13FGFR32.16277778
14CDK82.14304636
15PASK2.12513065
16NEK22.11991211
17SIK32.06807888
18TGFBR12.04151754
19SRPK12.03233412
20CDC72.01206060
21IRAK11.97793645
22AKT31.91990056
23STK38L1.91166153
24BRSK21.89506533
25BMPR1B1.81459236
26ZAK1.77458863
27ERBB21.77403234
28NEK91.76851883
29PDGFRA1.71952027
30VRK11.69731706
31TESK11.68935587
32STK161.52763943
33SGK21.52699301
34ATR1.49322878
35PBK1.48470219
36RPS6KA41.45674673
37MAP3K21.43329868
38TESK21.42292233
39PDK31.39782628
40PDK41.39782628
41WNK11.28547442
42IRAK21.28101630
43SGK31.27890498
44TLK11.27150297
45PDGFRB1.26591296
46STK241.23381976
47EPHB21.23214478
48FRK1.22407492
49RIPK11.19919190
50CDK71.19619394
51PRPF4B1.17872068
52TRPM71.10015075
53BRSK11.09504018
54AURKB1.09189197
55FGFR41.03416660
56TAF11.00209122
57IRAK40.99767145
58MAP3K60.98947782
59PLK10.96957161
60PKN20.95250077
61TSSK60.94165053
62TTN0.93819939
63STK100.92950983
64CDK40.91947298
65RET0.91105954
66MAP3K100.90671835
67MAP3K70.90476413
68CHEK20.88711371
69JAK10.86713896
70PNCK0.86212267
71MARK30.84697285
72SGK2230.82180687
73SGK4940.82180687
74YES10.82159329
75INSRR0.82155542
76CAMK1D0.81929815
77JAK30.81333285
78STK40.81283774
79PLK30.80130062
80LATS20.79491024
81PLK40.77101032
82MAP3K30.76066961
83KSR20.75944401
84CAMKK20.74801702
85PIM10.73815327
86ERBB30.72210923
87CHEK10.70973529
88SCYL20.70123983
89MKNK10.69092063
90DYRK1A0.67544165
91TEC0.66806259
92FGR0.65960399
93MAP3K40.64752743
94EIF2AK30.63748692
95ICK0.61894413
96MAP3K140.61494320
97CDK90.61478131
98MELK0.60775497
99MAPK150.60481812
100STK110.60197991
101RPS6KA50.59936109
102BTK0.59796386
103DMPK0.58881023
104RAF10.56860213
105EGFR0.55626047
106SGK10.55616393
107MET0.54395493
108MAPK100.52975941
109TNIK0.52241521
110EIF2AK20.51873509
111CASK0.51732995
112RPS6KB10.50427187
113ATM0.50389345
114RPS6KC10.50221636
115RPS6KL10.50221636
116RPS6KA60.49394881
117PIM20.48642487
118STK30.47937090
119NLK0.44643062
120PLK20.44608343
121ROCK20.44607674
122JAK20.43689921
123RPS6KA20.43449704
124ERN10.43174274
125ERBB40.42851345
126STK390.42760609
127BMX0.42235984
128PAK40.42020079
129MKNK20.41651078
130PDK20.41104652
131CDK20.40764599
132CDK30.40027379
133TTK0.39360727
134CDK10.38801154
135AKT20.38524114
136MTOR0.37698493
137AURKA0.37587080
138MUSK0.36553920
139FLT30.35336709
140TBK10.34559588
141PIK3CG0.33983326
142EEF2K0.33742858
143MAPK90.33665169
144PAK20.33663630
145NEK60.33117323
146FGFR10.32480748
147RPS6KB20.30108349
148CAMK1G0.28419105
149MAP4K10.27491253
150CDK60.25290233

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.06290007
2Mismatch repair_Homo sapiens_hsa034303.16151827
3Cell cycle_Homo sapiens_hsa041103.05627398
4RNA polymerase_Homo sapiens_hsa030202.86960486
5Base excision repair_Homo sapiens_hsa034102.62782589
6Homologous recombination_Homo sapiens_hsa034402.62450673
7Systemic lupus erythematosus_Homo sapiens_hsa053222.50344937
8Spliceosome_Homo sapiens_hsa030402.47822746
9RNA transport_Homo sapiens_hsa030132.40773661
10Pyrimidine metabolism_Homo sapiens_hsa002402.34827505
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25192412
12Fanconi anemia pathway_Homo sapiens_hsa034602.13915004
13p53 signaling pathway_Homo sapiens_hsa041152.11083168
14Nucleotide excision repair_Homo sapiens_hsa034202.10857360
15Adherens junction_Homo sapiens_hsa045202.03301586
16RNA degradation_Homo sapiens_hsa030182.03137225
17Non-homologous end-joining_Homo sapiens_hsa034502.02986693
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01514226
19Non-small cell lung cancer_Homo sapiens_hsa052231.99279270
20Basal cell carcinoma_Homo sapiens_hsa052171.97111220
21Basal transcription factors_Homo sapiens_hsa030221.96474049
22N-Glycan biosynthesis_Homo sapiens_hsa005101.84662303
23Thyroid cancer_Homo sapiens_hsa052161.81287549
24One carbon pool by folate_Homo sapiens_hsa006701.80780616
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71438772
26Ribosome_Homo sapiens_hsa030101.66418689
27mRNA surveillance pathway_Homo sapiens_hsa030151.59407417
28Lysine degradation_Homo sapiens_hsa003101.52229301
29Glioma_Homo sapiens_hsa052141.51681520
30Purine metabolism_Homo sapiens_hsa002301.50470623
31Renal cell carcinoma_Homo sapiens_hsa052111.45400821
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44364415
33Viral carcinogenesis_Homo sapiens_hsa052031.44306900
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43138247
35Proteasome_Homo sapiens_hsa030501.42786758
36Dorso-ventral axis formation_Homo sapiens_hsa043201.41197850
37mTOR signaling pathway_Homo sapiens_hsa041501.40357637
38Choline metabolism in cancer_Homo sapiens_hsa052311.35482041
39Alcoholism_Homo sapiens_hsa050341.35112454
40Acute myeloid leukemia_Homo sapiens_hsa052211.28725811
41Hedgehog signaling pathway_Homo sapiens_hsa043401.26556069
42ErbB signaling pathway_Homo sapiens_hsa040121.26178341
43HTLV-I infection_Homo sapiens_hsa051661.25981470
44Prolactin signaling pathway_Homo sapiens_hsa049171.25390054
45Pentose phosphate pathway_Homo sapiens_hsa000301.24151039
46MicroRNAs in cancer_Homo sapiens_hsa052061.24060689
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22936478
48Focal adhesion_Homo sapiens_hsa045101.18665098
49Circadian rhythm_Homo sapiens_hsa047101.13289853
50Herpes simplex infection_Homo sapiens_hsa051681.12560396
51Epstein-Barr virus infection_Homo sapiens_hsa051691.12428169
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09929864
53Hippo signaling pathway_Homo sapiens_hsa043901.08456657
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05222845
55Oocyte meiosis_Homo sapiens_hsa041141.03691107
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.01151660
57Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00410652
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.97282072
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92524355
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91906663
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90080652
62Small cell lung cancer_Homo sapiens_hsa052220.89912803
63Selenocompound metabolism_Homo sapiens_hsa004500.89397830
64Notch signaling pathway_Homo sapiens_hsa043300.88664419
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88562109
66Biosynthesis of amino acids_Homo sapiens_hsa012300.86293053
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85933540
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.85094708
69Hepatitis B_Homo sapiens_hsa051610.84158082
70Platelet activation_Homo sapiens_hsa046110.84042485
71Colorectal cancer_Homo sapiens_hsa052100.83520325
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82670032
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81181983
74Insulin signaling pathway_Homo sapiens_hsa049100.80015285
75Antigen processing and presentation_Homo sapiens_hsa046120.79957739
76Vitamin B6 metabolism_Homo sapiens_hsa007500.79900719
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.78497066
78Melanogenesis_Homo sapiens_hsa049160.76906080
79Long-term potentiation_Homo sapiens_hsa047200.76879790
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76870239
81Type II diabetes mellitus_Homo sapiens_hsa049300.76588921
82Chronic myeloid leukemia_Homo sapiens_hsa052200.72577905
83Tight junction_Homo sapiens_hsa045300.72344386
84Estrogen signaling pathway_Homo sapiens_hsa049150.72280449
85Legionellosis_Homo sapiens_hsa051340.71022722
86Apoptosis_Homo sapiens_hsa042100.70904333
87Insulin resistance_Homo sapiens_hsa049310.70006999
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67893390
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66730524
90Amoebiasis_Homo sapiens_hsa051460.66491727
91Wnt signaling pathway_Homo sapiens_hsa043100.65479582
92Rap1 signaling pathway_Homo sapiens_hsa040150.65137511
93TGF-beta signaling pathway_Homo sapiens_hsa043500.65063694
94Protein export_Homo sapiens_hsa030600.62544155
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61567586
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61065733
97VEGF signaling pathway_Homo sapiens_hsa043700.60988778
98Pathways in cancer_Homo sapiens_hsa052000.59839860
99MAPK signaling pathway_Homo sapiens_hsa040100.58818957
100Measles_Homo sapiens_hsa051620.58091648
101Pancreatic cancer_Homo sapiens_hsa052120.56829376
102GnRH signaling pathway_Homo sapiens_hsa049120.56769000
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55609448
104Ras signaling pathway_Homo sapiens_hsa040140.55169972
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.54948332
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54665109
107AMPK signaling pathway_Homo sapiens_hsa041520.54456159
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53139498
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51336937
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.50868262
111Folate biosynthesis_Homo sapiens_hsa007900.50705786
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50337886
113Gap junction_Homo sapiens_hsa045400.50017171
114Glucagon signaling pathway_Homo sapiens_hsa049220.49530048
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.48406371
116Axon guidance_Homo sapiens_hsa043600.48313672
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48311211
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48049478
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46833856
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45511669
121Hepatitis C_Homo sapiens_hsa051600.45269771
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.45136658
123Primary immunodeficiency_Homo sapiens_hsa053400.44901806
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44877198
125Thyroid hormone synthesis_Homo sapiens_hsa049180.44230354
126HIF-1 signaling pathway_Homo sapiens_hsa040660.43629798
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42517511
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39392510
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.37631975
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34135550
131ECM-receptor interaction_Homo sapiens_hsa045120.33784665
132Prostate cancer_Homo sapiens_hsa052150.30396482
133T cell receptor signaling pathway_Homo sapiens_hsa046600.29663290
134Melanoma_Homo sapiens_hsa052180.28496518
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28080069
136Proteoglycans in cancer_Homo sapiens_hsa052050.27543142
137Bladder cancer_Homo sapiens_hsa052190.27277748
138Inositol phosphate metabolism_Homo sapiens_hsa005620.23699201
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22429274
140Endometrial cancer_Homo sapiens_hsa052130.21697906
141Shigellosis_Homo sapiens_hsa051310.21274153
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.20681204
143Hematopoietic cell lineage_Homo sapiens_hsa046400.20055818
144FoxO signaling pathway_Homo sapiens_hsa040680.17732557
145B cell receptor signaling pathway_Homo sapiens_hsa046620.17078763
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16093508
147Malaria_Homo sapiens_hsa051440.15990352
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15737107

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