PTBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.35212032
2protein localization to kinetochore (GO:0034501)4.33960460
3nuclear pore organization (GO:0006999)4.14579430
4nuclear pore complex assembly (GO:0051292)4.08268282
5DNA strand elongation involved in DNA replication (GO:0006271)4.07438486
6mitotic nuclear envelope disassembly (GO:0007077)4.03591172
7folic acid-containing compound biosynthetic process (GO:0009396)4.02565793
8DNA replication initiation (GO:0006270)4.00276982
9COPI coating of Golgi vesicle (GO:0048205)3.93280952
10Golgi transport vesicle coating (GO:0048200)3.93280952
11DNA strand elongation (GO:0022616)3.86369591
12proline biosynthetic process (GO:0006561)3.86327809
13viral transcription (GO:0019083)3.84832590
14translational termination (GO:0006415)3.77653417
15regulation of mammary gland epithelial cell proliferation (GO:0033599)3.76309075
16spliceosomal tri-snRNP complex assembly (GO:0000244)3.75993628
17nuclear envelope disassembly (GO:0051081)3.73780730
18membrane disassembly (GO:0030397)3.73780730
19formation of translation preinitiation complex (GO:0001731)3.70843648
20maturation of SSU-rRNA (GO:0030490)3.70748638
21protein localization to chromosome, centromeric region (GO:0071459)3.63291986
22ribosomal small subunit assembly (GO:0000028)3.59918123
23protein complex localization (GO:0031503)3.59061128
24peptidyl-arginine omega-N-methylation (GO:0035247)3.54964568
25heterochromatin organization (GO:0070828)3.49714716
26IMP biosynthetic process (GO:0006188)3.48316404
27nucleobase biosynthetic process (GO:0046112)3.44846567
28DNA replication-dependent nucleosome organization (GO:0034723)3.43951996
29DNA replication-dependent nucleosome assembly (GO:0006335)3.43951996
30telomere maintenance via semi-conservative replication (GO:0032201)3.43596628
31cellular protein complex localization (GO:0034629)3.42135005
32DNA duplex unwinding (GO:0032508)3.41996136
33translational elongation (GO:0006414)3.40422817
34DNA geometric change (GO:0032392)3.38976779
35translational initiation (GO:0006413)3.38953181
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.38938650
37mitotic chromosome condensation (GO:0007076)3.31597259
38regulation of spindle organization (GO:0090224)3.30759844
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.28955476
40apoptotic process involved in morphogenesis (GO:0060561)3.26785361
41mitotic sister chromatid cohesion (GO:0007064)3.26576621
42chromosome condensation (GO:0030261)3.26119128
43DNA replication checkpoint (GO:0000076)3.24344881
44mitotic metaphase plate congression (GO:0007080)3.22669978
45protein-DNA complex disassembly (GO:0032986)3.21088457
46nucleosome disassembly (GO:0006337)3.21088457
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21037226
48regulation of translational termination (GO:0006449)3.21025294
49regulation of translational fidelity (GO:0006450)3.18835375
50sister chromatid segregation (GO:0000819)3.18465238
51mitotic sister chromatid segregation (GO:0000070)3.17432165
52pre-miRNA processing (GO:0031054)3.17370666
53establishment of integrated proviral latency (GO:0075713)3.14615473
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13518720
55pentose-phosphate shunt (GO:0006098)3.12784010
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12281631
57pore complex assembly (GO:0046931)3.11713863
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05556490
59IMP metabolic process (GO:0046040)3.04715447
60ribosomal small subunit biogenesis (GO:0042274)3.03723992
61telomere maintenance via recombination (GO:0000722)3.03464891
62mitotic recombination (GO:0006312)3.03340221
63adherens junction assembly (GO:0034333)3.02918649
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01619909
65histone arginine methylation (GO:0034969)3.01535579
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00958751
67nuclear envelope organization (GO:0006998)2.99319814
68protein targeting to ER (GO:0045047)2.96995808
69protein retention in ER lumen (GO:0006621)2.96896242
70translesion synthesis (GO:0019985)2.96817051
71cotranslational protein targeting to membrane (GO:0006613)2.94796094
72activation of Rac GTPase activity (GO:0032863)2.94190343
73metaphase plate congression (GO:0051310)2.93213585
74viral life cycle (GO:0019058)2.92351938
75protein export from nucleus (GO:0006611)2.92149330
76cell-substrate adherens junction assembly (GO:0007045)2.91571384
77focal adhesion assembly (GO:0048041)2.91571384
78regulation of histone H3-K9 methylation (GO:0051570)2.91446264
79cellular protein complex disassembly (GO:0043624)2.91394303
80dosage compensation (GO:0007549)2.90835568
81positive regulation of chromosome segregation (GO:0051984)2.90692003
82regulation of nucleobase-containing compound transport (GO:0032239)2.90645571
83negative regulation of histone methylation (GO:0031061)2.89099675
84* negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87622728
85* negative regulation of RNA splicing (GO:0033119)2.86699204
86regulation of sister chromatid cohesion (GO:0007063)2.86547177
87purine nucleobase biosynthetic process (GO:0009113)2.85617978
88ribosome assembly (GO:0042255)2.83871217
89peptidyl-arginine methylation (GO:0018216)2.83043244
90peptidyl-arginine N-methylation (GO:0035246)2.83043244
91protein complex disassembly (GO:0043241)2.82740795
92establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82739946
93telomere maintenance via telomere lengthening (GO:0010833)2.82359241
94regulation of mitotic spindle organization (GO:0060236)2.82215150
95regulation of posttranscriptional gene silencing (GO:0060147)2.81493038
96regulation of gene silencing by miRNA (GO:0060964)2.81493038
97regulation of gene silencing by RNA (GO:0060966)2.81493038
98negative regulation of erythrocyte differentiation (GO:0045647)2.81166539
99ribosomal large subunit biogenesis (GO:0042273)2.79903142
100regulation of NFAT protein import into nucleus (GO:0051532)2.78505519
1013-UTR-mediated mRNA stabilization (GO:0070935)2.78472167
102DNA conformation change (GO:0071103)2.77734357
103regulation of histone H3-K27 methylation (GO:0061085)2.77522155
104chromatin assembly (GO:0031497)2.76556608
105glucocorticoid receptor signaling pathway (GO:0042921)2.76549458
106regulation of RNA export from nucleus (GO:0046831)2.75316668
107protein localization to chromosome (GO:0034502)2.73927557
108regulation of chromatin binding (GO:0035561)2.73927427
109chromatin assembly or disassembly (GO:0006333)2.72547801
110mRNA stabilization (GO:0048255)2.72469732
111RNA stabilization (GO:0043489)2.72469732
112NADPH regeneration (GO:0006740)2.72283896
113nuclear-transcribed mRNA catabolic process (GO:0000956)2.72226629
114protein localization to endoplasmic reticulum (GO:0070972)2.70905499
115nucleotide-excision repair, DNA gap filling (GO:0006297)2.70136436
116maternal placenta development (GO:0001893)2.69790164
117embryonic process involved in female pregnancy (GO:0060136)2.69696010
118positive regulation of DNA-dependent DNA replication (GO:2000105)2.67823087
119DNA packaging (GO:0006323)2.66511970
120* mRNA splicing, via spliceosome (GO:0000398)2.65037210
121* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.65037210
122glucose catabolic process (GO:0006007)2.64537905
123DNA replication-independent nucleosome organization (GO:0034724)2.64112078
124DNA replication-independent nucleosome assembly (GO:0006336)2.64112078
125ribonucleoprotein complex biogenesis (GO:0022613)2.63724739
126* RNA splicing, via transesterification reactions (GO:0000375)2.63094306
127retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61747915
128kinetochore organization (GO:0051383)2.61534199
129RNA catabolic process (GO:0006401)2.61327860
130establishment of chromosome localization (GO:0051303)2.60773872
131rRNA transcription (GO:0009303)2.60107233
132intracellular estrogen receptor signaling pathway (GO:0030520)2.59816287
133mRNA catabolic process (GO:0006402)2.59261961
134mitotic nuclear envelope reassembly (GO:0007084)2.59109632
135nuclear envelope reassembly (GO:0031468)2.59109632
136macromolecular complex disassembly (GO:0032984)2.58830581
137trophectodermal cell differentiation (GO:0001829)2.58594002
138histone H2A monoubiquitination (GO:0035518)2.58429881
139regulation of chromosome segregation (GO:0051983)2.58064092
140DNA topological change (GO:0006265)2.57623140
141mitotic G1 DNA damage checkpoint (GO:0031571)2.57036647
142folic acid metabolic process (GO:0046655)2.55622013
143cellular response to epidermal growth factor stimulus (GO:0071364)2.54795826
144attachment of spindle microtubules to kinetochore (GO:0008608)2.53872728
145positive regulation of SMAD protein import into nucleus (GO:0060391)2.53018250
146proline metabolic process (GO:0006560)2.52268481
147regulation of early endosome to late endosome transport (GO:2000641)2.51521697
148negative regulation of cell size (GO:0045792)2.50367642
149nucleobase-containing small molecule interconversion (GO:0015949)2.50310940
150regulation of mRNA stability (GO:0043488)2.50252972
151ribosome biogenesis (GO:0042254)2.49255367
152postreplication repair (GO:0006301)2.49156760
153* negative regulation of mRNA processing (GO:0050686)2.48088494
154DNA synthesis involved in DNA repair (GO:0000731)2.48008748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.91457806
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.61412160
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.69965072
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39626108
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34070666
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.18795545
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00974766
8* MYC_22102868_ChIP-Seq_BL_Human2.77143088
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73517099
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33194099
11AR_21909140_ChIP-Seq_LNCAP_Human2.25163328
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16218981
13* XRN2_22483619_ChIP-Seq_HELA_Human2.07881625
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01761526
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00724435
16E2F1_21310950_ChIP-Seq_MCF-7_Human1.97754363
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.84512424
18* VDR_21846776_ChIP-Seq_THP-1_Human1.83880105
19* LXR_22292898_ChIP-Seq_THP-1_Human1.80132904
20* ETS1_20019798_ChIP-Seq_JURKAT_Human1.77491304
21* CIITA_25753668_ChIP-Seq_RAJI_Human1.70334294
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68968286
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68649070
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.66703059
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66242306
26* RACK7_27058665_Chip-Seq_MCF-7_Human1.66091641
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63842993
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60683444
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60189533
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59282169
31* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56306501
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.55117506
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51474421
34VDR_23849224_ChIP-Seq_CD4+_Human1.50080136
35* TTF2_22483619_ChIP-Seq_HELA_Human1.49445796
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48814271
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47712308
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46796965
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.46737487
40FOXP3_21729870_ChIP-Seq_TREG_Human1.45407667
41* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45155495
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44825478
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43195383
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42931139
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41131839
46DCP1A_22483619_ChIP-Seq_HELA_Human1.40646499
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40629035
48* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40180635
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40090096
50KDM5A_27292631_Chip-Seq_BREAST_Human1.39839592
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38775685
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38730815
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36841125
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36683792
55* GABP_19822575_ChIP-Seq_HepG2_Human1.36014729
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33920074
57CLOCK_20551151_ChIP-Seq_293T_Human1.33795021
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33004975
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30314407
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27096900
61TCF7_22412390_ChIP-Seq_EML_Mouse1.24836002
62* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23248410
63* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22019790
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21096476
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19985666
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19148497
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18410958
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.17769958
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.17571974
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16343096
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16087941
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15841769
73UTX_26944678_Chip-Seq_JUKART_Human1.15459827
74* TFEB_21752829_ChIP-Seq_HELA_Human1.15458345
75MAF_26560356_Chip-Seq_TH1_Human1.13746114
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13322247
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11463452
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09779614
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09654592
80* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09471150
81* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09162414
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08837188
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08621193
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07846413
85* P68_20966046_ChIP-Seq_HELA_Human1.07817477
86ELK1_19687146_ChIP-ChIP_HELA_Human1.07286403
87TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06237359
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05730400
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05058863
90KDM2B_26808549_Chip-Seq_K562_Human1.04817362
91* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04592749
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.01570660
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01535803
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01534937
95* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01168044
96MAF_26560356_Chip-Seq_TH2_Human1.01043457
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00312744
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.00143323
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99422327
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.98780215
101* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98332191
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98280531
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97226054
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96539907
105ATF3_27146783_Chip-Seq_COLON_Human0.96068943
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95940352
107SCL_19346495_ChIP-Seq_HPC-7_Human0.95793384
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95755886
109MYB_26560356_Chip-Seq_TH1_Human0.95519925
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95151693
111* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94111106
112CREB1_26743006_Chip-Seq_LNCaP_Human0.93842480
113MYB_26560356_Chip-Seq_TH2_Human0.93383693
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93127902
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93127902
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93127902
117* CHD1_26751641_Chip-Seq_LNCaP_Human0.92704059
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92331896
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92203758
120SPI1_23547873_ChIP-Seq_NB4_Human0.92183012
121HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91775883
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91523926
123KDM2B_26808549_Chip-Seq_DND41_Human0.90990256
124ZNF263_19887448_ChIP-Seq_K562_Human0.90125275
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90068075
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89846486
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.89096902
128* NCOR1_26117541_ChIP-Seq_K562_Human0.88586648
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88186300
130* VDR_24763502_ChIP-Seq_THP-1_Human0.87871085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.64768403
2MP0010094_abnormal_chromosome_stability3.25582536
3MP0003111_abnormal_nucleus_morphology3.22756231
4MP0004957_abnormal_blastocyst_morpholog3.21236165
5MP0003077_abnormal_cell_cycle2.93928077
6MP0010352_gastrointestinal_tract_polyps2.86205601
7MP0008057_abnormal_DNA_replication2.78485017
8MP0002396_abnormal_hematopoietic_system2.36205415
9MP0005451_abnormal_body_composition2.22316712
10MP0004185_abnormal_adipocyte_glucose2.17179906
11MP0005076_abnormal_cell_differentiation2.16154732
12MP0003705_abnormal_hypodermis_morpholog2.12925231
13MP0008007_abnormal_cellular_replicative2.12881112
14MP0001730_embryonic_growth_arrest2.12832832
15MP0000350_abnormal_cell_proliferation1.97596579
16MP0004808_abnormal_hematopoietic_stem1.84537206
17MP0008932_abnormal_embryonic_tissue1.84367179
18MP0010307_abnormal_tumor_latency1.82059813
19MP0003123_paternal_imprinting1.81365949
20MP0008058_abnormal_DNA_repair1.74052503
21MP0002796_impaired_skin_barrier1.72659801
22MP0010030_abnormal_orbit_morphology1.72063781
23MP0001672_abnormal_embryogenesis/_devel1.69039327
24MP0005380_embryogenesis_phenotype1.69039327
25MP0004858_abnormal_nervous_system1.66251390
26MP0000490_abnormal_crypts_of1.64473542
27MP0009278_abnormal_bone_marrow1.63148392
28MP0004233_abnormal_muscle_weight1.62971723
29MP0004197_abnormal_fetal_growth/weight/1.62786771
30MP0001697_abnormal_embryo_size1.62481487
31MP0009053_abnormal_anal_canal1.61051929
32MP0003984_embryonic_growth_retardation1.59974990
33MP0002084_abnormal_developmental_patter1.58030786
34MP0002088_abnormal_embryonic_growth/wei1.57935769
35MP0002085_abnormal_embryonic_tissue1.55918344
36MP0000537_abnormal_urethra_morphology1.54883114
37MP0000678_abnormal_parathyroid_gland1.53661997
38MP0002086_abnormal_extraembryonic_tissu1.52863434
39MP0006054_spinal_hemorrhage1.51929237
40MP0002080_prenatal_lethality1.46284317
41MP0003566_abnormal_cell_adhesion1.45932765
42MP0005623_abnormal_meninges_morphology1.38401718
43MP0000566_synostosis1.36704406
44MP0005397_hematopoietic_system_phenotyp1.35720001
45MP0001545_abnormal_hematopoietic_system1.35720001
46MP0003567_abnormal_fetal_cardiomyocyte1.34524280
47MP0005023_abnormal_wound_healing1.32817580
48MP0008260_abnormal_autophagy1.32093751
49MP0002009_preneoplasia1.31342207
50MP0003763_abnormal_thymus_physiology1.29552792
51MP0005257_abnormal_intraocular_pressure1.28537557
52MP0009333_abnormal_splenocyte_physiolog1.26976624
53MP0005058_abnormal_lysosome_morphology1.26199282
54MP0000703_abnormal_thymus_morphology1.24661274
55MP0001849_ear_inflammation1.23931933
56MP0002019_abnormal_tumor_incidence1.23267451
57MP0002249_abnormal_larynx_morphology1.20980151
58MP0001293_anophthalmia1.18033599
59MP0002089_abnormal_postnatal_growth/wei1.16765246
60MP0005666_abnormal_adipose_tissue1.15858895
61MP0001348_abnormal_lacrimal_gland1.15558536
62MP0000313_abnormal_cell_death1.13736885
63MP0003315_abnormal_perineum_morphology1.13508181
64MP0002060_abnormal_skin_morphology1.09984092
65MP0003300_gastrointestinal_ulcer1.08780982
66MP0003091_abnormal_cell_migration1.08479782
67MP0000003_abnormal_adipose_tissue1.08047130
68MP0002398_abnormal_bone_marrow1.07814985
69MP0000733_abnormal_muscle_development1.07239187
70MP0000428_abnormal_craniofacial_morphol1.05559824
71MP0005409_darkened_coat_color1.05222414
72MP0003786_premature_aging1.05040209
73MP0002722_abnormal_immune_system1.04079036
74MP0001915_intracranial_hemorrhage1.03012415
75MP0001346_abnormal_lacrimal_gland1.02218210
76MP0003119_abnormal_digestive_system0.98719908
77MP0009672_abnormal_birth_weight0.98069849
78MP0004264_abnormal_extraembryonic_tissu0.97514265
79MP0005375_adipose_tissue_phenotype0.97378528
80MP0003121_genomic_imprinting0.96046615
81MP0002092_abnormal_eye_morphology0.95286193
82MP0002111_abnormal_tail_morphology0.93712035
83MP0010234_abnormal_vibrissa_follicle0.93082027
84MP0009379_abnormal_foot_pigmentation0.92529620
85MP0003890_abnormal_embryonic-extraembry0.91367798
86MP0000689_abnormal_spleen_morphology0.91348251
87MP0000858_altered_metastatic_potential0.91024291
88MP0003115_abnormal_respiratory_system0.88304749
89MP0000685_abnormal_immune_system0.88271024
90MP0003937_abnormal_limbs/digits/tail_de0.88170527
91MP0002925_abnormal_cardiovascular_devel0.87130349
92MP0000477_abnormal_intestine_morphology0.86034559
93MP0009931_abnormal_skin_appearance0.85530968
94MP0009703_decreased_birth_body0.83551562
95MP0003935_abnormal_craniofacial_develop0.83267290
96MP0003941_abnormal_skin_development0.82394035
97MP0002429_abnormal_blood_cell0.81984469
98MP0003303_peritoneal_inflammation0.80645606
99MP0001661_extended_life_span0.79907270
100MP0000465_gastrointestinal_hemorrhage0.79833038
101MP0002697_abnormal_eye_size0.79507456
102MP0010630_abnormal_cardiac_muscle0.79003919
103MP0009840_abnormal_foam_cell0.78756322
104MP0000432_abnormal_head_morphology0.78406693
105MP0008877_abnormal_DNA_methylation0.78282172
106MP0002932_abnormal_joint_morphology0.76671220
107MP0000377_abnormal_hair_follicle0.76408751
108MP0003385_abnormal_body_wall0.76101229
109MP0001881_abnormal_mammary_gland0.75803870
110MP0002877_abnormal_melanocyte_morpholog0.75115112
111MP0000762_abnormal_tongue_morphology0.74864811
112MP0004782_abnormal_surfactant_physiolog0.74719994
113MP0000716_abnormal_immune_system0.73150610
114MP0002405_respiratory_system_inflammati0.72752502
115MP0005501_abnormal_skin_physiology0.72564985
116MP0002653_abnormal_ependyma_morphology0.72273177
117MP0000383_abnormal_hair_follicle0.72221073
118MP0005621_abnormal_cell_physiology0.70685647
119MP0001873_stomach_inflammation0.69561128
120MP0001286_abnormal_eye_development0.68960869
121MP0002282_abnormal_trachea_morphology0.68112680
122MP0001216_abnormal_epidermal_layer0.67934856
123MP0010155_abnormal_intestine_physiology0.67437104
124MP0001800_abnormal_humoral_immune0.67198692
125MP0001243_abnormal_dermal_layer0.65936654
126MP0008438_abnormal_cutaneous_collagen0.65554074
127MP0002166_altered_tumor_susceptibility0.63693858
128MP0003453_abnormal_keratinocyte_physiol0.63655070
129MP0002098_abnormal_vibrissa_morphology0.63390114
130MP0004947_skin_inflammation0.62934337
131MP0005384_cellular_phenotype0.62562935
132MP0004272_abnormal_basement_membrane0.62279166
133MP0003942_abnormal_urinary_system0.61974684

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.42444071
2Selective tooth agenesis (HP:0001592)3.34178946
3Short 4th metacarpal (HP:0010044)3.14968197
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.14968197
5Abnormality of cells of the erythroid lineage (HP:0012130)2.92237982
6Ependymoma (HP:0002888)2.89110140
7Colon cancer (HP:0003003)2.82366340
8Deviation of the thumb (HP:0009603)2.81498109
9Proximal placement of thumb (HP:0009623)2.80831818
10Medulloblastoma (HP:0002885)2.74018174
11Premature rupture of membranes (HP:0001788)2.73246165
12Abnormal number of erythroid precursors (HP:0012131)2.70110665
13Disproportionate tall stature (HP:0001519)2.66154408
14Broad face (HP:0000283)2.61338630
15Long palpebral fissure (HP:0000637)2.60807914
16Insomnia (HP:0100785)2.50636771
17Increased nuchal translucency (HP:0010880)2.49019038
18Basal cell carcinoma (HP:0002671)2.43853118
19Progressive muscle weakness (HP:0003323)2.43789757
20Abnormality of the distal phalanx of the thumb (HP:0009617)2.41404358
21Broad distal phalanx of finger (HP:0009836)2.41072697
22Birth length less than 3rd percentile (HP:0003561)2.39889759
23Achilles tendon contracture (HP:0001771)2.37240329
24Protrusio acetabuli (HP:0003179)2.35391385
25Abnormality of the 4th metacarpal (HP:0010012)2.30794305
26Patellar aplasia (HP:0006443)2.30784198
27Abnormal number of incisors (HP:0011064)2.30558736
28Flat acetabular roof (HP:0003180)2.29963716
29Abnormality of the fingertips (HP:0001211)2.28363825
30Atresia of the external auditory canal (HP:0000413)2.23089732
31Ankyloglossia (HP:0010296)2.20151124
32Distal lower limb amyotrophy (HP:0008944)2.20104462
33Long eyelashes (HP:0000527)2.19444112
34Aplasia/Hypoplasia of the patella (HP:0006498)2.19432075
35Increased density of long bones (HP:0006392)2.17504411
36High pitched voice (HP:0001620)2.17438215
37Breast hypoplasia (HP:0003187)2.17423372
38Asymmetry of the thorax (HP:0001555)2.16766999
39High anterior hairline (HP:0009890)2.15607700
40Ankle contracture (HP:0006466)2.15182549
41Thrombocytosis (HP:0001894)2.13140339
42Vertebral compression fractures (HP:0002953)2.12512249
43Hyperacusis (HP:0010780)2.10771031
44Abnormality of oral frenula (HP:0000190)2.09955551
45Abnormality of the Achilles tendon (HP:0005109)2.06146161
46Abnormality of the distal phalanges of the toes (HP:0010182)2.06040059
47Ectopic kidney (HP:0000086)2.05935648
48Trismus (HP:0000211)2.04157840
49Rhabdomyosarcoma (HP:0002859)2.03690855
50Skin tags (HP:0010609)2.03586878
51Abnormality of the anterior horn cell (HP:0006802)2.02484588
52Degeneration of anterior horn cells (HP:0002398)2.02484588
53Renal duplication (HP:0000075)2.01469264
54Neoplasm of the pancreas (HP:0002894)2.01354793
55Chromsome breakage (HP:0040012)2.00510535
56Missing ribs (HP:0000921)2.00491019
57Shallow orbits (HP:0000586)1.99638164
58Overriding aorta (HP:0002623)1.99067271
59Pallor (HP:0000980)1.98867101
60Oral leukoplakia (HP:0002745)1.98744465
6111 pairs of ribs (HP:0000878)1.98598874
62Centrally nucleated skeletal muscle fibers (HP:0003687)1.97335944
63Overlapping toe (HP:0001845)1.96240009
64Abnormality of the calcaneus (HP:0008364)1.96040287
65Abnormality of the thoracic spine (HP:0100711)1.95732525
66Prominent nose (HP:0000448)1.94659780
67Volvulus (HP:0002580)1.94203519
68Neoplasm of the oral cavity (HP:0100649)1.93834911
69Urethral obstruction (HP:0000796)1.93509787
70Neoplasm of striated muscle (HP:0009728)1.93041631
71Macrocytic anemia (HP:0001972)1.91515033
72Patellar dislocation (HP:0002999)1.91421277
73Myelodysplasia (HP:0002863)1.89218730
74Preauricular skin tag (HP:0000384)1.89062298
75Abnormality of the phalanges of the hallux (HP:0010057)1.88287123
76Microvesicular hepatic steatosis (HP:0001414)1.87570402
77Biconcave vertebral bodies (HP:0004586)1.86261307
78Spinal cord lesions (HP:0100561)1.86255049
79Syringomyelia (HP:0003396)1.86255049
80Pointed chin (HP:0000307)1.84768073
81Increased connective tissue (HP:0009025)1.83333990
82Abnormal gallbladder physiology (HP:0012438)1.82750781
83Cholecystitis (HP:0001082)1.82750781
84Dysmetric saccades (HP:0000641)1.82730496
85Elfin facies (HP:0004428)1.82357904
86Abnormality of the astrocytes (HP:0100707)1.82176349
87Astrocytoma (HP:0009592)1.82176349
88Aplastic anemia (HP:0001915)1.81880937
89Agnosia (HP:0010524)1.81852622
90Reticulocytosis (HP:0001923)1.81290744
91Septate vagina (HP:0001153)1.80386789
92Abnormality of chromosome stability (HP:0003220)1.79993435
93Arnold-Chiari malformation (HP:0002308)1.79415646
94Premature skin wrinkling (HP:0100678)1.79366921
95Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78980590
96Squamous cell carcinoma (HP:0002860)1.78899934
97Broad thumb (HP:0011304)1.78894912
98Malignant gastrointestinal tract tumors (HP:0006749)1.78446061
99Gastrointestinal carcinoma (HP:0002672)1.78446061
100Advanced eruption of teeth (HP:0006288)1.78040220
101Absent radius (HP:0003974)1.77922252
102Rectal prolapse (HP:0002035)1.77596054
103Amaurosis fugax (HP:0100576)1.77406630
104Meckel diverticulum (HP:0002245)1.77216697
105Absent thumb (HP:0009777)1.76452030
106Short nail (HP:0001799)1.76066715
107Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75875506
108Ulnar bowing (HP:0003031)1.75261293
109Deep palmar crease (HP:0006191)1.74444983
110Flared metaphyses (HP:0003015)1.74419095
111Bicuspid aortic valve (HP:0001647)1.74258245
112Natal tooth (HP:0000695)1.73794269
113Broad palm (HP:0001169)1.73389820
114Abnormality of the umbilical cord (HP:0010881)1.73095747
115Multiple enchondromatosis (HP:0005701)1.72755929
116Trigonocephaly (HP:0000243)1.69808253
117Facial hemangioma (HP:0000329)1.69036143
118Metaphyseal cupping (HP:0003021)1.68953653
119Short 5th finger (HP:0009237)1.68938578
120Abnormality of the ileum (HP:0001549)1.68932038
121Skull defect (HP:0001362)1.68084703
122Distal upper limb amyotrophy (HP:0007149)1.66929407
123Upper limb amyotrophy (HP:0009129)1.66929407
124Biliary tract neoplasm (HP:0100574)1.66923075
125IgM deficiency (HP:0002850)1.65771095
126Carpal bone hypoplasia (HP:0001498)1.65645338
127Abnormality of the peritoneum (HP:0002585)1.64987731
128Sparse lateral eyebrow (HP:0005338)1.64610451
129Genu recurvatum (HP:0002816)1.64314602
130Progressive external ophthalmoplegia (HP:0000590)1.64249018
131Blepharitis (HP:0000498)1.64125095
132Small intestinal stenosis (HP:0012848)1.63456796
133Duodenal stenosis (HP:0100867)1.63456796
134Aplasia involving forearm bones (HP:0009822)1.63250109
135Absent forearm bone (HP:0003953)1.63250109
136Turricephaly (HP:0000262)1.62624163
137Cerebral aneurysm (HP:0004944)1.62536503
138Tracheoesophageal fistula (HP:0002575)1.62235036
139Thoracic kyphosis (HP:0002942)1.62063397
140Thin ribs (HP:0000883)1.61941211
141Persistence of primary teeth (HP:0006335)1.61925536
142Rough bone trabeculation (HP:0100670)1.61612582
143Back pain (HP:0003418)1.61146518
144Dislocated radial head (HP:0003083)1.60986065
145Supernumerary ribs (HP:0005815)1.60654880
146Glossoptosis (HP:0000162)1.60345512
147Fragile skin (HP:0001030)1.60114199
148Cutis marmorata (HP:0000965)1.59857699
149Duplication of thumb phalanx (HP:0009942)1.59548257
150Abnormality of the salivary glands (HP:0010286)1.58617703
151Orthostatic hypotension (HP:0001278)1.57778591
152Slender long bone (HP:0003100)1.57629266
153Midface retrusion (HP:0011800)1.56970414
154Mitral regurgitation (HP:0001653)1.56595030
155Abnormality of abdominal situs (HP:0011620)1.56517417
156Abdominal situs inversus (HP:0003363)1.56517417
157Pseudobulbar signs (HP:0002200)1.56383436
158Osteolytic defects of the hand bones (HP:0009699)1.56270067
159Osteolytic defects of the phalanges of the hand (HP:0009771)1.56270067
160Impulsivity (HP:0100710)1.55997436
161Broad phalanges of the hand (HP:0009768)1.55833173
162Spastic diplegia (HP:0001264)1.55799039
163Supernumerary bones of the axial skeleton (HP:0009144)1.55609519
164Glioma (HP:0009733)1.55370066
165Truncus arteriosus (HP:0001660)1.55265476
166Abnormality of reticulocytes (HP:0004312)1.55250502
167Elbow flexion contracture (HP:0002987)1.54064623
168Ragged-red muscle fibers (HP:0003200)1.53220992
169Abnormal ossification of hand bones (HP:0005921)1.52986161
170Progressive hearing impairment (HP:0001730)1.51993430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.55216904
2EEF2K3.58335000
3CDC73.50923260
4CDK123.19549858
5MAP3K102.98795040
6WEE12.86725901
7PRPF4B2.67171596
8NEK22.65096816
9BUB12.63688079
10IRAK32.33737012
11TRIB32.29167383
12PKN22.21517351
13STK102.00942501
14PASK2.00370116
15RPS6KB21.99512092
16TSSK61.84486965
17MAP4K11.80199318
18CDK71.73443731
19RPS6KA41.69587821
20TGFBR11.66640191
21TTK1.66401363
22CDK41.63900901
23MAP3K81.49475827
24LRRK21.48706355
25PAK41.46036147
26EPHA21.44132899
27NME21.41053427
28BRD41.40008840
29VRK21.35996271
30ATR1.34910328
31SCYL21.33242503
32TESK21.32989716
33MKNK11.32693194
34DYRK31.30897174
35AURKB1.30438623
36FLT31.29877515
37BRSK21.28969130
38MST1R1.25535143
39PLK11.25024871
40ACVR1B1.22339415
41EIF2AK11.22099269
42CDK61.18923138
43ERN11.17271895
44NEK11.15950364
45LATS11.15869095
46TAOK21.13605231
47MTOR1.10697199
48PTK61.10127634
49CHEK11.07814216
50SRPK11.02336124
51MAP2K30.99549241
52STK30.95895868
53STK40.95488207
54PIM10.95436551
55ALK0.95021460
56CHEK20.92040955
57TTN0.91397337
58PAK20.88873372
59KDR0.88034867
60BTK0.82681561
61ZAP700.81835315
62CAMK1D0.81539307
63KSR20.81398293
64MKNK20.80443527
65MAP3K130.79725986
66PLK40.79020982
67JAK30.78754158
68BRAF0.76712773
69CDK20.76559648
70TAF10.76557901
71PLK30.76423829
72PDGFRA0.75526790
73MAPK110.74378680
74ATM0.73977440
75TLK10.73892354
76AURKA0.70112278
77MELK0.68684328
78GRK60.68330275
79ARAF0.67100337
80PBK0.66659268
81ICK0.63414114
82FGFR10.63273382
83VRK10.61094031
84SIK10.59860105
85EIF2AK30.58044253
86BRSK10.58031324
87BMX0.57928989
88MAP3K30.57744249
89MAPKAPK30.57195351
90MAP3K110.56477028
91MET0.56318376
92CDK90.55345130
93RPS6KC10.54661855
94RPS6KL10.54661855
95PIM20.53954631
96PAK10.53861339
97TESK10.53683748
98MAP3K140.52350292
99LATS20.50882158
100TYRO30.50230019
101CDK10.49581390
102FGFR40.48404026
103PRKD20.48048248
104CDC42BPA0.48044109
105CSF1R0.47445427
106HIPK20.47367895
107CHUK0.47323434
108MAP3K10.46200973
109CLK10.45474160
110CAMK1G0.45411507
111RPS6KA20.45233983
112CSNK2A20.45187023
113TAOK10.45161878
114LMTK20.44842269
115IRAK20.43696096
116AKT20.43662760
117NLK0.43108208
118MARK20.42435637
119ITK0.41539487
120ILK0.41252723
121MAPKAPK20.40286379
122PRKD30.39646847
123CDK80.39026054
124NTRK10.38707741
125MAP2K20.37401815
126EPHB10.37275494
127MAP3K90.37181623
128KIT0.36563346
129PTK20.35656791
130RIPK10.35648246
131RPS6KA10.34750170
132TGFBR20.34059860
133MAPK10.33794236
134RPS6KA50.32280725

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.40536517
2Mismatch repair_Homo sapiens_hsa034303.42572549
3Spliceosome_Homo sapiens_hsa030403.01979177
4RNA transport_Homo sapiens_hsa030132.87205708
5Ribosome_Homo sapiens_hsa030102.79851138
6Cell cycle_Homo sapiens_hsa041102.76580311
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73421116
8Base excision repair_Homo sapiens_hsa034102.67591291
9One carbon pool by folate_Homo sapiens_hsa006702.64755170
10Nucleotide excision repair_Homo sapiens_hsa034202.21529348
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15641682
12Homologous recombination_Homo sapiens_hsa034402.14031138
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78757535
14RNA polymerase_Homo sapiens_hsa030201.77386701
15mRNA surveillance pathway_Homo sapiens_hsa030151.73582532
16p53 signaling pathway_Homo sapiens_hsa041151.72333302
17Non-homologous end-joining_Homo sapiens_hsa034501.71263250
18Pyrimidine metabolism_Homo sapiens_hsa002401.61192903
19Fanconi anemia pathway_Homo sapiens_hsa034601.57876847
20RNA degradation_Homo sapiens_hsa030181.50228705
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43967428
22Antigen processing and presentation_Homo sapiens_hsa046121.39800939
23Fructose and mannose metabolism_Homo sapiens_hsa000511.39362399
24Small cell lung cancer_Homo sapiens_hsa052221.34037853
25Viral carcinogenesis_Homo sapiens_hsa052031.30071675
26Proteasome_Homo sapiens_hsa030501.29611402
27MicroRNAs in cancer_Homo sapiens_hsa052061.29013739
28HTLV-I infection_Homo sapiens_hsa051661.27041151
29Chronic myeloid leukemia_Homo sapiens_hsa052201.23619365
30Herpes simplex infection_Homo sapiens_hsa051681.22932273
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20018677
32Epstein-Barr virus infection_Homo sapiens_hsa051691.18089293
33Other glycan degradation_Homo sapiens_hsa005111.17069953
34Basal cell carcinoma_Homo sapiens_hsa052171.15580752
35Carbon metabolism_Homo sapiens_hsa012001.14629172
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14389506
37Galactose metabolism_Homo sapiens_hsa000521.13897493
38Notch signaling pathway_Homo sapiens_hsa043301.08702325
39Thyroid cancer_Homo sapiens_hsa052161.06800114
40Basal transcription factors_Homo sapiens_hsa030221.06686324
41Selenocompound metabolism_Homo sapiens_hsa004501.00934621
42Prion diseases_Homo sapiens_hsa050201.00693279
43Primary immunodeficiency_Homo sapiens_hsa053400.99525557
44VEGF signaling pathway_Homo sapiens_hsa043700.99111833
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98877717
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98479825
47Adherens junction_Homo sapiens_hsa045200.95945848
48Renal cell carcinoma_Homo sapiens_hsa052110.95808002
49Systemic lupus erythematosus_Homo sapiens_hsa053220.93747594
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93344919
51Hippo signaling pathway_Homo sapiens_hsa043900.92203485
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88850130
53Acute myeloid leukemia_Homo sapiens_hsa052210.87003515
54Glioma_Homo sapiens_hsa052140.86249961
55TGF-beta signaling pathway_Homo sapiens_hsa043500.86190490
56Bladder cancer_Homo sapiens_hsa052190.86129934
57Lysine degradation_Homo sapiens_hsa003100.84655461
58Colorectal cancer_Homo sapiens_hsa052100.84628189
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84347794
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.83650926
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83279016
62Hepatitis B_Homo sapiens_hsa051610.81739235
63ErbB signaling pathway_Homo sapiens_hsa040120.79181666
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79033237
65Apoptosis_Homo sapiens_hsa042100.78917568
66Insulin signaling pathway_Homo sapiens_hsa049100.77462406
67Legionellosis_Homo sapiens_hsa051340.77248539
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.77071500
69Pentose phosphate pathway_Homo sapiens_hsa000300.76281989
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76162822
71Proteoglycans in cancer_Homo sapiens_hsa052050.75253864
72Hedgehog signaling pathway_Homo sapiens_hsa043400.75115753
73Measles_Homo sapiens_hsa051620.74229774
74Viral myocarditis_Homo sapiens_hsa054160.74221443
75Shigellosis_Homo sapiens_hsa051310.73891657
76Biosynthesis of amino acids_Homo sapiens_hsa012300.70039168
77Prostate cancer_Homo sapiens_hsa052150.68113926
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.67947520
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67912181
80Pathways in cancer_Homo sapiens_hsa052000.66954752
81Pancreatic cancer_Homo sapiens_hsa052120.66928327
82AMPK signaling pathway_Homo sapiens_hsa041520.66280857
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.66189293
84B cell receptor signaling pathway_Homo sapiens_hsa046620.63788760
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63568399
86Non-small cell lung cancer_Homo sapiens_hsa052230.61681250
87Hepatitis C_Homo sapiens_hsa051600.61579873
88Oocyte meiosis_Homo sapiens_hsa041140.61354106
89mTOR signaling pathway_Homo sapiens_hsa041500.59638178
90Toxoplasmosis_Homo sapiens_hsa051450.58846700
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57649183
92Purine metabolism_Homo sapiens_hsa002300.57339391
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55998027
94Leishmaniasis_Homo sapiens_hsa051400.55128558
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54828369
96Melanoma_Homo sapiens_hsa052180.54084426
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53518879
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52859576
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.51922168
100Focal adhesion_Homo sapiens_hsa045100.51483955
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50992338
102Hematopoietic cell lineage_Homo sapiens_hsa046400.50890977
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50644659
104T cell receptor signaling pathway_Homo sapiens_hsa046600.50308414
105N-Glycan biosynthesis_Homo sapiens_hsa005100.50092084
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.49590492
107ECM-receptor interaction_Homo sapiens_hsa045120.49527343
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.47365711
109Sulfur relay system_Homo sapiens_hsa041220.47069817
110HIF-1 signaling pathway_Homo sapiens_hsa040660.46227730
111Influenza A_Homo sapiens_hsa051640.45352753
112Vitamin B6 metabolism_Homo sapiens_hsa007500.45276837
113Endometrial cancer_Homo sapiens_hsa052130.43574224
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43003008
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41895111
116Choline metabolism in cancer_Homo sapiens_hsa052310.41850246
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41782509
118Inositol phosphate metabolism_Homo sapiens_hsa005620.41665650
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41651892
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40783905
121Prolactin signaling pathway_Homo sapiens_hsa049170.40670044
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40649267
123Wnt signaling pathway_Homo sapiens_hsa043100.38818368
124Folate biosynthesis_Homo sapiens_hsa007900.38394124
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.37812922
126Renin-angiotensin system_Homo sapiens_hsa046140.35785917
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34754036
128Osteoclast differentiation_Homo sapiens_hsa043800.32880107
129FoxO signaling pathway_Homo sapiens_hsa040680.31726263

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