PTBP1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)5.51615388
2opsonization (GO:0008228)5.50952840
3musculoskeletal movement (GO:0050881)5.38282433
4multicellular organismal movement (GO:0050879)5.38282433
5regulation of glomerulus development (GO:0090192)5.37306623
6regulation of cell proliferation involved in kidney development (GO:1901722)5.19361319
7cellular response to ATP (GO:0071318)5.03776938
8striated muscle atrophy (GO:0014891)4.71314942
9pattern specification involved in kidney development (GO:0061004)4.68969161
10negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.45797790
11nephron tubule formation (GO:0072079)4.38740634
12positive regulation of growth hormone secretion (GO:0060124)4.37628792
13positive regulation of metanephros development (GO:0072216)4.36468054
14tolerance induction (GO:0002507)4.34532431
15regulation of phospholipid biosynthetic process (GO:0071071)4.32523646
16negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.22978876
17cellular anion homeostasis (GO:0030002)4.21361699
18positive regulation of fatty acid beta-oxidation (GO:0032000)4.13542659
19male sex determination (GO:0030238)4.11445581
20negative regulation of oligodendrocyte differentiation (GO:0048715)4.09209676
21negative regulation of inclusion body assembly (GO:0090084)4.08604273
22regulation of chromatin binding (GO:0035561)4.04001814
23regulation of mesenchymal cell apoptotic process (GO:2001053)4.00961044
24multicellular organism reproduction (GO:0032504)4.00935149
25sulfation (GO:0051923)4.00388797
26alternative mRNA splicing, via spliceosome (GO:0000380)3.92742010
27angiogenesis involved in wound healing (GO:0060055)3.83251232
28positive regulation of fatty acid oxidation (GO:0046321)3.77801345
29protein refolding (GO:0042026)3.72083988
30negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.70501603
31negative regulation of hormone biosynthetic process (GO:0032353)3.68310068
32sleep (GO:0030431)3.67086679
33muscle atrophy (GO:0014889)3.59666727
34gamma-aminobutyric acid transport (GO:0015812)3.46269698
35tooth mineralization (GO:0034505)3.44738433
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38941410
37behavioral response to nicotine (GO:0035095)3.33345585
38negative regulation of skeletal muscle tissue development (GO:0048642)3.31336686
39CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.31286672
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.30634090
41negative regulation by host of viral transcription (GO:0043922)3.29119108
42neuroblast proliferation (GO:0007405)3.27958409
43lung secretory cell differentiation (GO:0061140)3.24659753
44DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.23556610
45otic vesicle formation (GO:0030916)3.22623711
46regulation of apoptotic process involved in morphogenesis (GO:1902337)3.22110373
47negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.18479973
48response to UV-C (GO:0010225)3.17607272
49regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.17253860
50sperm motility (GO:0030317)3.16331213
51negative regulation of platelet activation (GO:0010544)3.15523758
52neuronal stem cell maintenance (GO:0097150)3.15053136
53negative regulation of gene silencing (GO:0060969)3.11223406
54negative regulation of hormone metabolic process (GO:0032351)3.10683842
55protein polyglutamylation (GO:0018095)3.10165152
56sperm capacitation (GO:0048240)3.09973509
57chaperone mediated protein folding requiring cofactor (GO:0051085)3.09107559
58plasma membrane repair (GO:0001778)3.05285405
59cell proliferation in forebrain (GO:0021846)3.04676658
60antigen processing and presentation of endogenous antigen (GO:0019883)3.03816672
61DNA damage response, signal transduction resulting in transcription (GO:0042772)3.01192743
62regulation of metanephros development (GO:0072215)3.00031242
63positive regulation of chondrocyte differentiation (GO:0032332)2.99763868
64positive regulation of cAMP-mediated signaling (GO:0043950)2.98680954
65reproduction (GO:0000003)2.93560165
66negative regulation of response to food (GO:0032096)2.93044182
67negative regulation of appetite (GO:0032099)2.93044182
683-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.90646832
69purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.90646832
70nephron tubule morphogenesis (GO:0072078)2.89570195
71nephron epithelium morphogenesis (GO:0072088)2.89570195
72regulation of cholesterol storage (GO:0010885)2.84885048
73neuron fate determination (GO:0048664)2.84273149
74membrane protein intracellular domain proteolysis (GO:0031293)2.84235026
75skeletal muscle adaptation (GO:0043501)2.83489297
76protein K6-linked ubiquitination (GO:0085020)2.82933623
77lung cell differentiation (GO:0060479)2.82662468
78positive regulation of endothelial cell differentiation (GO:0045603)2.81639513
79mast cell degranulation (GO:0043303)2.80849055
80mast cell activation involved in immune response (GO:0002279)2.80849055
81regulation of receptor biosynthetic process (GO:0010869)2.79724111
82lung epithelial cell differentiation (GO:0060487)2.79313926
83regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.78253019
84inactivation of MAPK activity (GO:0000188)2.76498004
85response to inactivity (GO:0014854)2.73907091
86regulation of transcription involved in cell fate commitment (GO:0060850)2.70016217
87positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.69889580
88regulation of B cell receptor signaling pathway (GO:0050855)2.68354792
89lung morphogenesis (GO:0060425)2.66643714
90negative regulation of myotube differentiation (GO:0010832)2.65012964
91cell-cell signaling involved in cell fate commitment (GO:0045168)2.63994315
92developmental induction (GO:0031128)2.63719433
93microtubule depolymerization (GO:0007019)2.62362992
94regulation of protein heterodimerization activity (GO:0043497)2.60192901
95cellular response to exogenous dsRNA (GO:0071360)2.59250936
96astrocyte differentiation (GO:0048708)2.57379641
97morphogenesis of an endothelium (GO:0003159)2.56960477
98endothelial tube morphogenesis (GO:0061154)2.56960477
99mast cell activation (GO:0045576)2.56270345
100endocardial cushion morphogenesis (GO:0003203)2.56085736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.55690837
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.27920590
3EZH2_22144423_ChIP-Seq_EOC_Human3.16872778
4MYC_22102868_ChIP-Seq_BL_Human2.84646843
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52329394
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46388839
7RUNX_20019798_ChIP-Seq_JUKART_Human2.42826546
8LXR_22292898_ChIP-Seq_THP-1_Human2.40366723
9MAF_26560356_Chip-Seq_TH1_Human2.34464881
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30662221
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.30185351
12SRY_22984422_ChIP-ChIP_TESTIS_Rat2.27680240
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26457775
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.25660268
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16827044
16VDR_21846776_ChIP-Seq_THP-1_Human2.08943490
17BCL6_27268052_Chip-Seq_Bcells_Human2.07685030
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05064514
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.01159399
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99039758
21IRF1_19129219_ChIP-ChIP_H3396_Human1.97411563
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86845912
23UTX_26944678_Chip-Seq_JUKART_Human1.85152149
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78913593
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77866826
26CIITA_25753668_ChIP-Seq_RAJI_Human1.75063643
27MYB_26560356_Chip-Seq_TH2_Human1.73717836
28MYB_26560356_Chip-Seq_TH1_Human1.73543666
29TP53_20018659_ChIP-ChIP_R1E_Mouse1.71725070
30P68_20966046_ChIP-Seq_HELA_Human1.71000183
31VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.69319700
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.69219669
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61984705
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60266413
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58305723
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.56923418
37UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54617670
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51329821
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49774606
40BCOR_27268052_Chip-Seq_Bcells_Human1.49250318
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.46504776
42SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45482108
43HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.45426191
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43803969
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42025665
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.37282863
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.37221333
48ELK4_26923725_Chip-Seq_MESODERM_Mouse1.36398153
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.36196694
50TCF7_22412390_ChIP-Seq_EML_Mouse1.36002357
51SPI1_20517297_ChIP-Seq_HL60_Human1.35542908
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35038833
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31378432
54SMC4_20622854_ChIP-Seq_HELA_Human1.30495102
55E2F1_20622854_ChIP-Seq_HELA_Human1.30143158
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28991274
57P300_27268052_Chip-Seq_Bcells_Human1.25786787
58MAF_26560356_Chip-Seq_TH2_Human1.24401738
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22993052
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22909321
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22734685
62PHF8_20622854_ChIP-Seq_HELA_Human1.22317871
63VDR_24763502_ChIP-Seq_THP-1_Human1.20949218
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20878639
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19757951
66KDM2B_26808549_Chip-Seq_DND41_Human1.19530204
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.19153048
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18302005
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18185340
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17904017
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.17428638
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.15875102
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14972880
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13958711
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13378795
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.13212561
77TP53_22127205_ChIP-Seq_IMR90_Human1.12840539
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12195277
79CTCF_20526341_ChIP-Seq_ESCs_Human1.12014738
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.11212918
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.10481972
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.09757747
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08477590
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07907533
85RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07265582
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07229270
87TP53_23651856_ChIP-Seq_MEFs_Mouse1.07003277
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06370391
89GATA3_27048872_Chip-Seq_THYMUS_Human1.06313650
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05965723
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05629651
92TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04056414
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03774683
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03500285
95RACK7_27058665_Chip-Seq_MCF-7_Human1.03198597
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.01815168
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01117668
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00019388
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96232230
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96110520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.79267430
2MP0004145_abnormal_muscle_electrophysio4.17658513
3MP0002138_abnormal_hepatobiliary_system3.66673436
4MP0002089_abnormal_postnatal_growth/wei3.38029715
5MP0004134_abnormal_chest_morphology2.38262537
6MP0005670_abnormal_white_adipose2.37833531
7MP0000049_abnormal_middle_ear2.36909572
8MP0002282_abnormal_trachea_morphology2.35723504
9MP0002163_abnormal_gland_morphology2.13307576
10MP0008872_abnormal_physiological_respon2.09647645
11MP0000747_muscle_weakness2.05811323
12MP0009250_abnormal_appendicular_skeleto2.03964747
13MP0004510_myositis2.01926934
14MP0000733_abnormal_muscle_development1.90426204
15MP0004130_abnormal_muscle_cell1.85072267
16MP0005410_abnormal_fertilization1.82105691
17MP0005671_abnormal_response_to1.77950563
18MP0001485_abnormal_pinna_reflex1.75627337
19MP0001800_abnormal_humoral_immune1.66954255
20MP0000685_abnormal_immune_system1.65487811
21MP0000537_abnormal_urethra_morphology1.64690507
22MP0002733_abnormal_thermal_nociception1.63712957
23MP0002653_abnormal_ependyma_morphology1.63439191
24MP0000678_abnormal_parathyroid_gland1.62686424
25MP0009384_cardiac_valve_regurgitation1.60982175
26MP0005083_abnormal_biliary_tract1.60829844
27MP0001835_abnormal_antigen_presentation1.59993852
28MP0004885_abnormal_endolymph1.57499106
29MP0003638_abnormal_response/metabolism_1.54620308
30MP0005387_immune_system_phenotype1.52655689
31MP0001790_abnormal_immune_system1.52655689
32MP0005464_abnormal_platelet_physiology1.50670041
33MP0004270_analgesia1.44593709
34MP0005000_abnormal_immune_tolerance1.44030990
35MP0001853_heart_inflammation1.42721574
36MP0002249_abnormal_larynx_morphology1.41995242
37MP0002139_abnormal_hepatobiliary_system1.41489811
38MP0000534_abnormal_ureter_morphology1.39528092
39MP0001348_abnormal_lacrimal_gland1.39105394
40MP0004742_abnormal_vestibular_system1.33187846
41MP0000631_abnormal_neuroendocrine_gland1.32604916
42MP0004142_abnormal_muscle_tone1.32496969
43MP0003436_decreased_susceptibility_to1.30815232
44MP0002723_abnormal_immune_serum1.29827989
45MP0002452_abnormal_antigen_presenting1.26671082
46MP0005084_abnormal_gallbladder_morpholo1.26617955
47MP0000750_abnormal_muscle_regeneration1.25742854
48MP0004947_skin_inflammation1.22297737
49MP0001968_abnormal_touch/_nociception1.19171972
50MP0005379_endocrine/exocrine_gland_phen1.18808683
51MP0010094_abnormal_chromosome_stability1.18645363
52MP0001819_abnormal_immune_cell1.18012410
53MP0002420_abnormal_adaptive_immunity1.17379653
54MP0005645_abnormal_hypothalamus_physiol1.16612908
55MP0000703_abnormal_thymus_morphology1.16078576
56MP0006072_abnormal_retinal_apoptosis1.15419717
57MP0002398_abnormal_bone_marrow1.14233515
58MP0002735_abnormal_chemical_nociception1.12697497
59MP0008789_abnormal_olfactory_epithelium1.10248493
60MP0000689_abnormal_spleen_morphology1.09147265
61MP0000759_abnormal_skeletal_muscle1.09125452
62MP0002928_abnormal_bile_duct1.07611398
63MP0000490_abnormal_crypts_of1.04846981
64MP0002734_abnormal_mechanical_nocicepti1.03965534
65MP0003938_abnormal_ear_development1.03453460
66MP0000613_abnormal_salivary_gland1.03006372
67MP0008569_lethality_at_weaning1.01792655
68MP0002722_abnormal_immune_system1.01491641
69MP0001929_abnormal_gametogenesis0.98795248
70MP0000716_abnormal_immune_system0.97512964
71MP0003091_abnormal_cell_migration0.97395076
72MP0005646_abnormal_pituitary_gland0.95677803
73MP0005310_abnormal_salivary_gland0.94810310
74MP0003115_abnormal_respiratory_system0.94034771
75MP0003566_abnormal_cell_adhesion0.92602597
76MP0000749_muscle_degeneration0.92539569
77MP0003763_abnormal_thymus_physiology0.90595158
78MP0001963_abnormal_hearing_physiology0.90500151
79MP0004197_abnormal_fetal_growth/weight/0.90015750
80MP0009785_altered_susceptibility_to0.86375391
81MP0003693_abnormal_embryo_hatching0.86226709
82MP0000026_abnormal_inner_ear0.84862912
83MP0000003_abnormal_adipose_tissue0.84413254
84MP0005025_abnormal_response_to0.83113340
85MP0002106_abnormal_muscle_physiology0.82771699
86MP0008961_abnormal_basal_metabolism0.82377421
87MP0006292_abnormal_olfactory_placode0.80013121
88MP0003866_abnormal_defecation0.79458841
89MP0002419_abnormal_innate_immunity0.78511191
90MP0002429_abnormal_blood_cell0.78066770
91MP0001529_abnormal_vocalization0.76769120
92MP0001664_abnormal_digestion0.76721859
93MP0003646_muscle_fatigue0.75212957
94MP0003879_abnormal_hair_cell0.74518279
95MP0003077_abnormal_cell_cycle0.71516672
96MP0002132_abnormal_respiratory_system0.71484714
97MP0009333_abnormal_splenocyte_physiolog0.70302069
98MP0002736_abnormal_nociception_after0.69604111
99MP0002210_abnormal_sex_determination0.69040203
100MP0001873_stomach_inflammation0.68520990

Predicted human phenotypes

RankGene SetZ-score
1Diplopia (HP:0000651)5.46173251
2Abnormality of binocular vision (HP:0011514)5.46173251
3Genetic anticipation (HP:0003743)4.87072846
4Confusion (HP:0001289)4.59196363
5Visual hallucinations (HP:0002367)4.47503458
611 pairs of ribs (HP:0000878)4.10396581
7Morphological abnormality of the middle ear (HP:0008609)3.76576598
8Progressive cerebellar ataxia (HP:0002073)3.56174494
9Agitation (HP:0000713)3.55679540
10Menstrual irregularities (HP:0000858)3.53700487
11Porencephaly (HP:0002132)3.35343551
12IgG deficiency (HP:0004315)3.34766783
13Progressive sensorineural hearing impairment (HP:0000408)3.30845503
14Morphological abnormality of the inner ear (HP:0011390)3.22985674
15Unilateral renal agenesis (HP:0000122)3.12565807
16Palpebral edema (HP:0100540)3.07013614
17Mask-like facies (HP:0000298)2.96738924
18Abnormality of the columella (HP:0009929)2.87821720
19Ulnar deviation of the wrist (HP:0003049)2.85075806
20Severe visual impairment (HP:0001141)2.82284314
21Pendular nystagmus (HP:0012043)2.76259615
22Fibular hypoplasia (HP:0003038)2.73961460
23Homocystinuria (HP:0002156)2.73953262
24Abnormality of homocysteine metabolism (HP:0010919)2.73953262
25Hemiplegia (HP:0002301)2.64923754
26Gastrointestinal stroma tumor (HP:0100723)2.61588047
27Hypoplastic iliac wings (HP:0002866)2.61201457
28Progressive hearing impairment (HP:0001730)2.59990028
29Aplasia/Hypoplasia of the sternum (HP:0006714)2.58596637
30Short phalanx of the thumb (HP:0009660)2.51059177
31Myotonia (HP:0002486)2.49724802
32Impaired smooth pursuit (HP:0007772)2.44219530
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44041286
34Short 4th metacarpal (HP:0010044)2.44041286
35Decreased subcutaneous fat (HP:0001002)2.42837458
36True hermaphroditism (HP:0010459)2.42481523
37Abnormality of ocular smooth pursuit (HP:0000617)2.38851994
38Lower limb amyotrophy (HP:0007210)2.37640277
39Abnormality of the phalanges of the 2nd finger (HP:0009541)2.36165121
40Abnormality of hair growth rate (HP:0011363)2.35965282
41Slow-growing hair (HP:0002217)2.35965282
423-Methylglutaconic aciduria (HP:0003535)2.35177418
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34340817
44Plagiocephaly (HP:0001357)2.32855120
45Glucose intolerance (HP:0000833)2.32713619
46IgA deficiency (HP:0002720)2.31094056
47Chronic otitis media (HP:0000389)2.30469208
48Down-sloping shoulders (HP:0200021)2.30057057
49Action tremor (HP:0002345)2.29365102
50Abnormality of the nasal septum (HP:0000419)2.28691634
51Recurrent sinusitis (HP:0011108)2.26424408
52Panhypogammaglobulinemia (HP:0003139)2.21355340
53Truncal obesity (HP:0001956)2.17969012
54Broad hallux (HP:0010055)2.15367480
55Emphysema (HP:0002097)2.14388458
56Neoplasm of the heart (HP:0100544)2.14166962
57Abnormality of the wing of the ilium (HP:0011867)2.13652461
58Abnormality of DNA repair (HP:0003254)2.12716346
59Nasal polyposis (HP:0100582)2.12115523
60Absent thumb (HP:0009777)2.12009309
61Recurrent viral infections (HP:0004429)2.11216930
62Lymphopenia (HP:0001888)2.10297755
63Cleft eyelid (HP:0000625)2.10008551
64IgM deficiency (HP:0002850)2.04689849
65Hypoplastic pelvis (HP:0008839)2.04353400
66Bicornuate uterus (HP:0000813)2.03478483
67Tinnitus (HP:0000360)2.01865865
68Abnormal sex determination (HP:0012244)2.00068182
69Sex reversal (HP:0012245)2.00068182
70Reduced subcutaneous adipose tissue (HP:0003758)1.98207083
71Hypoventilation (HP:0002791)1.96729376
72Aplasia/Hypoplasia of the spleen (HP:0010451)1.96285418
73Asplenia (HP:0001746)1.94556645
74Trigonocephaly (HP:0000243)1.92668913
752-3 toe syndactyly (HP:0004691)1.84784368
76Methylmalonic aciduria (HP:0012120)1.84487011
77Azoospermia (HP:0000027)1.84224588
78Hypoplasia of the uterus (HP:0000013)1.84218129
79Aplasia/Hypoplasia of the fibula (HP:0006492)1.84127627
80Abnormality of methionine metabolism (HP:0010901)1.83959507
81Abnormality of cells of the lymphoid lineage (HP:0012140)1.83334789
82Male pseudohermaphroditism (HP:0000037)1.82775744
83Conical tooth (HP:0000698)1.81827501
84Neonatal short-limb short stature (HP:0008921)1.81756811
85Abnormality of cochlea (HP:0000375)1.81266539
86Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.80873255
87Short 1st metacarpal (HP:0010034)1.80873255
88Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.80742967
89Irregular vertebral endplates (HP:0003301)1.80739901
90Menorrhagia (HP:0000132)1.80624640
91Interstitial pulmonary disease (HP:0006530)1.79354618
92Abnormality of the middle phalanges of the toes (HP:0010183)1.78273690
93Abnormal spermatogenesis (HP:0008669)1.77696976
94Restlessness (HP:0000711)1.77690270
95Short femoral neck (HP:0100864)1.77477012
96Gonadotropin excess (HP:0000837)1.76858821
97Septate vagina (HP:0001153)1.75752654
98Absent phalangeal crease (HP:0006109)1.75716840
99Male infertility (HP:0003251)1.75397575
100Abnormality of the distal phalanges of the toes (HP:0010182)1.73404987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK14.50105208
2TESK24.29936261
3TESK14.02806869
4TLK13.66909865
5PRKD23.38050779
6TSSK63.19561017
7ZAK2.98486459
8MAP3K92.86664556
9MAP4K12.74610475
10SMG12.58259195
11LMTK22.45409530
12BUB11.77985663
13WEE11.76121494
14GRK61.75714496
15CAMKK21.71377263
16ICK1.65779985
17VRK11.60112587
18EPHA21.53234528
19DAPK21.46553941
20BRAF1.45270886
21AURKA1.43898717
22TBK11.41901073
23GRK11.41422871
24LIMK11.32466609
25CCNB11.28438189
26PTK2B1.28326324
27MAPK111.23377775
28PNCK1.19793127
29MAPKAPK31.16999420
30MAPKAPK51.12542173
31BLK1.11814111
32MAPK151.10453788
33MAP2K21.07607259
34ARAF1.07549501
35MAP3K141.04460923
36CDK91.04189158
37PKN11.03634244
38EIF2AK21.01711564
39RIPK40.99453745
40CAMKK10.99358792
41SCYL20.98240677
42VRK20.98043755
43MELK0.96999252
44IKBKB0.93435241
45PKN20.93160520
46MAP3K110.93031897
47NEK90.88707377
48CAMK1D0.86018870
49MOS0.85888309
50TAF10.78125827
51CDK40.78099667
52GRK50.74470412
53PTK60.70225329
54MST1R0.69729965
55CHEK20.69349900
56SYK0.68265734
57FGFR40.67980796
58TRIB30.67603447
59ERBB20.66649546
60SIK10.65399150
61CDK120.65145094
62PAK10.64463517
63CSF1R0.63976890
64RPS6KA50.62378426
65STK380.61370988
66IKBKE0.59849764
67NME20.59547877
68BTK0.59143163
69TAOK10.58729485
70MARK20.58585255
71JAK30.58578967
72CAMK40.57606673
73PHKG10.55642285
74PHKG20.55642285
75STK40.53434079
76PRKCI0.52501773
77EEF2K0.51485040
78PRKD10.50037076
79MAP3K80.46444715
80AKT20.45765627
81CSNK1G20.43521196
82CHUK0.42618395
83TIE10.42394804
84MAP3K10.39905332
85MAP4K20.39567450
86PAK60.38481711
87CSNK1G30.37223944
88PIM20.36330401
89LATS20.35403122
90PRKCQ0.34511791
91ROCK10.34334755
92ADRBK20.33711764
93MAPKAPK20.33096024
94PDK10.32985962
95INSRR0.32910663
96TAOK30.32808065
97BRSK10.32676935
98PIM10.30308621
99SIK20.27652480
100CLK10.27152911

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.69266799
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.41015725
3Primary immunodeficiency_Homo sapiens_hsa053403.16604034
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.86536706
5Antigen processing and presentation_Homo sapiens_hsa046122.85613781
6Alcoholism_Homo sapiens_hsa050342.71402200
7Graft-versus-host disease_Homo sapiens_hsa053322.57595779
8Viral carcinogenesis_Homo sapiens_hsa052032.34350727
9DNA replication_Homo sapiens_hsa030302.13975158
10Allograft rejection_Homo sapiens_hsa053302.09556032
11Autoimmune thyroid disease_Homo sapiens_hsa053202.04334757
12B cell receptor signaling pathway_Homo sapiens_hsa046621.88386662
13Asthma_Homo sapiens_hsa053101.88088901
14Notch signaling pathway_Homo sapiens_hsa043301.88073403
15Fatty acid biosynthesis_Homo sapiens_hsa000611.84985405
16Renin-angiotensin system_Homo sapiens_hsa046141.69637251
17Melanoma_Homo sapiens_hsa052181.55850865
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.55747254
19Morphine addiction_Homo sapiens_hsa050321.46895507
20Epstein-Barr virus infection_Homo sapiens_hsa051691.39584704
21Measles_Homo sapiens_hsa051621.37464764
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.36435400
23Type I diabetes mellitus_Homo sapiens_hsa049401.32035798
24Viral myocarditis_Homo sapiens_hsa054161.28969335
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28151834
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27120437
27Herpes simplex infection_Homo sapiens_hsa051681.25420170
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24976039
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24291219
30MAPK signaling pathway_Homo sapiens_hsa040101.20070650
31Influenza A_Homo sapiens_hsa051641.11485825
32Spliceosome_Homo sapiens_hsa030401.10042058
33Nicotine addiction_Homo sapiens_hsa050331.09632078
34T cell receptor signaling pathway_Homo sapiens_hsa046601.07067864
35Sulfur relay system_Homo sapiens_hsa041221.06769063
36Tight junction_Homo sapiens_hsa045301.06424483
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01207737
38Type II diabetes mellitus_Homo sapiens_hsa049301.00686620
39Gap junction_Homo sapiens_hsa045400.98884840
40Estrogen signaling pathway_Homo sapiens_hsa049150.96093086
41HTLV-I infection_Homo sapiens_hsa051660.95966685
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94417311
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89662507
44Glioma_Homo sapiens_hsa052140.86735537
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85777815
46Toxoplasmosis_Homo sapiens_hsa051450.85177116
47Galactose metabolism_Homo sapiens_hsa000520.85100532
48Bladder cancer_Homo sapiens_hsa052190.85014779
49Sulfur metabolism_Homo sapiens_hsa009200.79822842
50Prostate cancer_Homo sapiens_hsa052150.78125905
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77721891
52GABAergic synapse_Homo sapiens_hsa047270.76864826
53Shigellosis_Homo sapiens_hsa051310.75105535
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74419079
55Long-term depression_Homo sapiens_hsa047300.72717610
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72458310
57Hedgehog signaling pathway_Homo sapiens_hsa043400.71622607
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71385735
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70517530
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69243405
61Hematopoietic cell lineage_Homo sapiens_hsa046400.66938599
62Endocytosis_Homo sapiens_hsa041440.66867044
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64618045
64Apoptosis_Homo sapiens_hsa042100.63497784
65Synaptic vesicle cycle_Homo sapiens_hsa047210.63239750
66Basal cell carcinoma_Homo sapiens_hsa052170.63067791
67MicroRNAs in cancer_Homo sapiens_hsa052060.61902724
68Nitrogen metabolism_Homo sapiens_hsa009100.60907227
69Thyroid cancer_Homo sapiens_hsa052160.59684568
70Serotonergic synapse_Homo sapiens_hsa047260.58760154
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.55753797
72Non-small cell lung cancer_Homo sapiens_hsa052230.55656501
73Cholinergic synapse_Homo sapiens_hsa047250.54997532
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53501023
75Oocyte meiosis_Homo sapiens_hsa041140.53471293
76Legionellosis_Homo sapiens_hsa051340.52168401
77Hepatitis C_Homo sapiens_hsa051600.52123461
78Cell cycle_Homo sapiens_hsa041100.51294075
79Fat digestion and absorption_Homo sapiens_hsa049750.49458388
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.48209587
81Platelet activation_Homo sapiens_hsa046110.47271743
82Rap1 signaling pathway_Homo sapiens_hsa040150.47180124
83N-Glycan biosynthesis_Homo sapiens_hsa005100.46523347
84Leishmaniasis_Homo sapiens_hsa051400.46128831
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43568114
86Taste transduction_Homo sapiens_hsa047420.43302115
87Acute myeloid leukemia_Homo sapiens_hsa052210.43286616
88Homologous recombination_Homo sapiens_hsa034400.42459775
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41640039
90Chemokine signaling pathway_Homo sapiens_hsa040620.35464154
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35296749
92Salivary secretion_Homo sapiens_hsa049700.35202300
93TNF signaling pathway_Homo sapiens_hsa046680.33992712
94Phototransduction_Homo sapiens_hsa047440.32767795
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32719610
96Ras signaling pathway_Homo sapiens_hsa040140.31612148
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31216168
98Glutamatergic synapse_Homo sapiens_hsa047240.30429664
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30138166
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.29952275

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