PTBP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.63165443
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.63165443
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46271414
4antigen processing and presentation of endogenous antigen (GO:0019883)4.34299123
5positive regulation of gamma-delta T cell activation (GO:0046645)4.21536627
6hepatocyte apoptotic process (GO:0097284)3.52618834
7embryonic process involved in female pregnancy (GO:0060136)3.49857750
8positive regulation of B cell differentiation (GO:0045579)3.48131561
9detection of molecule of bacterial origin (GO:0032490)3.47208692
10histone H3-K36 demethylation (GO:0070544)3.44070244
11regulation of gamma-delta T cell differentiation (GO:0045586)3.41589875
12detection of other organism (GO:0098543)3.37194050
13regulation of histone H3-K27 methylation (GO:0061085)3.28051590
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.27664590
15negative regulation of phagocytosis (GO:0050765)3.27405100
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23502498
17regulation of RNA export from nucleus (GO:0046831)3.22616113
18negative regulation of erythrocyte differentiation (GO:0045647)3.19928303
19regulation of gamma-delta T cell activation (GO:0046643)3.18495576
20positive regulation by symbiont of host defense response (GO:0052509)3.16623907
21modulation by symbiont of host defense response (GO:0052031)3.16623907
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.16623907
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.16623907
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.16623907
25modulation by symbiont of host immune response (GO:0052553)3.16623907
26regulation of B cell receptor signaling pathway (GO:0050855)3.13650971
27phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.10736061
28mitotic sister chromatid cohesion (GO:0007064)3.09939088
29detection of external biotic stimulus (GO:0098581)3.06660505
30regulation of interleukin-12 biosynthetic process (GO:0045075)3.06187946
31definitive hemopoiesis (GO:0060216)3.00462506
32regulation of B cell differentiation (GO:0045577)2.98868549
33detection of bacterium (GO:0016045)2.98663792
34regulation of interferon-beta biosynthetic process (GO:0045357)2.97327236
35response to host immune response (GO:0052572)2.92966223
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.92966223
37nuclear pore complex assembly (GO:0051292)2.89843508
38response to host defenses (GO:0052200)2.88397224
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88397224
40response to host (GO:0075136)2.88397224
41leukocyte aggregation (GO:0070486)2.87700263
42positive thymic T cell selection (GO:0045059)2.87507357
43positive regulation of interferon-alpha production (GO:0032727)2.86876238
44negative regulation of B cell proliferation (GO:0030889)2.83631553
45regulation of interferon-alpha production (GO:0032647)2.79130789
46iron ion import (GO:0097286)2.78813344
47JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.77736755
48positive regulation of histone deacetylation (GO:0031065)2.77582690
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76339158
50neutrophil activation involved in immune response (GO:0002283)2.75703827
51B cell receptor signaling pathway (GO:0050853)2.74161424
52positive regulation of granulocyte differentiation (GO:0030854)2.72884379
53pre-miRNA processing (GO:0031054)2.72004054
54immunoglobulin mediated immune response (GO:0016064)2.71938229
55regulation of nucleobase-containing compound transport (GO:0032239)2.71445958
56bundle of His cell to Purkinje myocyte communication (GO:0086069)2.71121072
57COPI coating of Golgi vesicle (GO:0048205)2.69478338
58Golgi transport vesicle coating (GO:0048200)2.69478338
59negative regulation of T cell mediated immunity (GO:0002710)2.68351030
60detection of biotic stimulus (GO:0009595)2.64175838
61response to interleukin-15 (GO:0070672)2.62785967
62neutrophil activation (GO:0042119)2.60974000
63hypotonic response (GO:0006971)2.59389726
64cellular extravasation (GO:0045123)2.58866836
65antigen processing and presentation via MHC class Ib (GO:0002475)2.56820650
66actin nucleation (GO:0045010)2.55252720
67negative regulation of cell killing (GO:0031342)2.54973743
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.54973743
69response to peptidoglycan (GO:0032494)2.54405418
70pinocytosis (GO:0006907)2.53479656
71negative regulation of DNA repair (GO:0045738)2.52367897
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.49977669
73pore complex assembly (GO:0046931)2.49891192
74nuclear pore organization (GO:0006999)2.48260940
75histone lysine demethylation (GO:0070076)2.46739811
76granulocyte activation (GO:0036230)2.45548803
77positive regulation of cellular amide metabolic process (GO:0034250)2.45070025
78cellular response to zinc ion (GO:0071294)2.44973832
79cytoplasmic mRNA processing body assembly (GO:0033962)2.44379207
80positive regulation of protein import into nucleus, translocation (GO:0033160)2.43736649
81negative regulation of interleukin-12 production (GO:0032695)2.43074892
82myeloid cell activation involved in immune response (GO:0002275)2.42950982
83negative regulation of bone resorption (GO:0045779)2.42644538
84tolerance induction (GO:0002507)2.41964359
85lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41785984
86regulation of DNA endoreduplication (GO:0032875)2.41000555
87positive regulation of leukocyte degranulation (GO:0043302)2.39988314
88germ cell migration (GO:0008354)2.39681442
89production of molecular mediator involved in inflammatory response (GO:0002532)2.38702072
90macrophage activation (GO:0042116)2.36994059
91necroptotic process (GO:0070266)2.36371801
92response to type I interferon (GO:0034340)2.35857897
93regulation of leukocyte degranulation (GO:0043300)2.34627583
94trophectodermal cell differentiation (GO:0001829)2.34227023
95positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.33959986
96negative regulation of granulocyte differentiation (GO:0030853)2.33090553
97microglial cell activation (GO:0001774)2.32828983
98histone demethylation (GO:0016577)2.32640778
99monoubiquitinated protein deubiquitination (GO:0035520)2.31866124
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.31212370
101dendritic cell migration (GO:0036336)2.30537928
102natural killer cell differentiation (GO:0001779)2.30313019
103leukocyte cell-cell adhesion (GO:0007159)2.30007502
104regulation of histone H3-K9 methylation (GO:0051570)2.29941673
105B cell mediated immunity (GO:0019724)2.29854546
106negative T cell selection (GO:0043383)2.29769240
107positive regulation of interferon-beta production (GO:0032728)2.29453501
108response to muramyl dipeptide (GO:0032495)2.28836307
109negative thymic T cell selection (GO:0045060)2.28745328
110sequestering of metal ion (GO:0051238)2.26868163
111regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.26836540
112B cell proliferation (GO:0042100)2.26717960
113T cell migration (GO:0072678)2.26539202
114T cell homeostasis (GO:0043029)2.26367102
115germinal center formation (GO:0002467)2.26284479
116respiratory burst (GO:0045730)2.26212202
117lymphocyte homeostasis (GO:0002260)2.26021349
118mRNA transcription (GO:0009299)2.25880594
119B cell homeostasis (GO:0001782)2.25480974
120positive regulation of macrophage differentiation (GO:0045651)2.24904230
121dosage compensation (GO:0007549)2.24523739
122cellular response to type I interferon (GO:0071357)2.24418903
123type I interferon signaling pathway (GO:0060337)2.24418903
124thymic T cell selection (GO:0045061)2.23785481
125macrophage activation involved in immune response (GO:0002281)2.23724608
126mRNA stabilization (GO:0048255)2.23498484
127RNA stabilization (GO:0043489)2.23498484
128negative regulation of lymphocyte mediated immunity (GO:0002707)2.23468248
129myeloid dendritic cell activation (GO:0001773)2.22160682
130positive T cell selection (GO:0043368)2.21281435
131growth hormone receptor signaling pathway (GO:0060396)2.20269108
132megakaryocyte development (GO:0035855)2.19932684
133positive regulation of erythrocyte differentiation (GO:0045648)2.19755317
134mitotic chromosome condensation (GO:0007076)2.19551303
135interferon-gamma production (GO:0032609)2.19476573
136positive regulation of protein deacetylation (GO:0090312)2.19148590
137histone mRNA catabolic process (GO:0071044)2.19091072
1383-UTR-mediated mRNA stabilization (GO:0070935)2.18753753
139positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.16339879
140interferon-gamma-mediated signaling pathway (GO:0060333)2.15031284
141regulation of erythrocyte differentiation (GO:0045646)2.14946677
142natural killer cell mediated immunity (GO:0002228)2.13544541
143natural killer cell mediated cytotoxicity (GO:0042267)2.13544541
144angiogenesis involved in wound healing (GO:0060055)2.12759516
145response to protozoan (GO:0001562)2.12233128
146T cell selection (GO:0045058)2.10340825
147positive regulation of lamellipodium assembly (GO:0010592)2.09526144
148regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.09345870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.99333712
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.00369104
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.84896767
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.82105222
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34201027
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.17702274
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.11516040
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.05468687
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79656884
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.71581568
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67032706
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57325897
13MYC_22102868_ChIP-Seq_BL_Human2.56021321
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48704656
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47608627
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45786636
17GATA1_22025678_ChIP-Seq_K562_Human2.41670283
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.38284077
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.21422369
20SCL_19346495_ChIP-Seq_HPC-7_Human2.19088205
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18511421
22MYB_26560356_Chip-Seq_TH2_Human2.16653980
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16196191
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09747094
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03583874
26VDR_21846776_ChIP-Seq_THP-1_Human2.02839302
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.01839334
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97383760
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.96512070
30MYB_26560356_Chip-Seq_TH1_Human1.94215716
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91547299
32MAF_26560356_Chip-Seq_TH1_Human1.89747448
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85505248
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85392638
35* SPI1_23547873_ChIP-Seq_NB4_Human1.82718496
36RUNX_20019798_ChIP-Seq_JUKART_Human1.82148289
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.73956525
38TCF7_22412390_ChIP-Seq_EML_Mouse1.71399973
39VDR_24763502_ChIP-Seq_THP-1_Human1.69268201
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67733150
41UTX_26944678_Chip-Seq_JUKART_Human1.67589568
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.63856487
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57777357
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50291126
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.47365595
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47328105
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44772003
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.43966542
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43750403
50PU_27001747_Chip-Seq_BMDM_Mouse1.41162405
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40785567
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40020967
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38149216
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37884004
55GATA3_27048872_Chip-Seq_THYMUS_Human1.35427683
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34376539
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33919059
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32681396
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29529799
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27314535
61SPI1_23127762_ChIP-Seq_K562_Human1.25651225
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24150421
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22900108
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21104346
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18177605
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18123211
67VDR_24787735_ChIP-Seq_THP-1_Human1.17888647
68AR_21909140_ChIP-Seq_LNCAP_Human1.16305749
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13062113
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12602607
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11524894
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11146022
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10504096
74CLOCK_20551151_ChIP-Seq_293T_Human1.09506412
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08324676
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08301709
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.07987923
78TFEB_21752829_ChIP-Seq_HELA_Human1.05783561
79ELK1_19687146_ChIP-ChIP_HELA_Human1.03935761
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03368569
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03353166
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03029831
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02477817
84CIITA_25753668_ChIP-Seq_RAJI_Human1.01048455
85CHD1_26751641_Chip-Seq_LNCaP_Human1.00618369
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00128966
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99922371
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99922371
89NCOR1_26117541_ChIP-Seq_K562_Human0.99513978
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99320280
91MAF_26560356_Chip-Seq_TH2_Human0.98430840
92GATA6_25053715_ChIP-Seq_YYC3_Human0.98133219
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.98055192
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.96604622
95KDM2B_26808549_Chip-Seq_DND41_Human0.95583454
96GATA3_26560356_Chip-Seq_TH2_Human0.95116800
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93212911
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92815168
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.92172149
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91867302
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90624859
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90277360
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89056749
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88899574
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88020487
106GATA1_19941826_ChIP-Seq_K562_Human0.87880515
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.85687906
108* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84831244
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84345520
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83125267
111PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83000193
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82047840
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81859438
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80332021
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79826965
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79763425
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79584064
118ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78817229
119GATA2_19941826_ChIP-Seq_K562_Human0.78663448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer2.97164950
2MP0001835_abnormal_antigen_presentation2.75772849
3MP0003303_peritoneal_inflammation2.69391977
4MP0002166_altered_tumor_susceptibility2.39661847
5MP0003436_decreased_susceptibility_to2.30370124
6MP0010352_gastrointestinal_tract_polyps2.29666435
7MP0002396_abnormal_hematopoietic_system2.20451131
8MP0001800_abnormal_humoral_immune2.17766189
9MP0010234_abnormal_vibrissa_follicle2.11453130
10MP0006054_spinal_hemorrhage2.08920178
11MP0002796_impaired_skin_barrier2.04993412
12MP0005671_abnormal_response_to2.02584445
13MP0001790_abnormal_immune_system2.00604080
14MP0005387_immune_system_phenotype2.00604080
15MP0005451_abnormal_body_composition1.99764307
16MP0002877_abnormal_melanocyte_morpholog1.99284714
17MP0000685_abnormal_immune_system1.98906474
18MP0002452_abnormal_antigen_presenting1.98181850
19MP0005000_abnormal_immune_tolerance1.94104283
20MP0002006_tumorigenesis1.90226067
21MP0003763_abnormal_thymus_physiology1.87751969
22MP0004947_skin_inflammation1.87248873
23MP0004808_abnormal_hematopoietic_stem1.84940527
24MP0009785_altered_susceptibility_to1.80993465
25MP0002420_abnormal_adaptive_immunity1.80477967
26MP0002723_abnormal_immune_serum1.80348667
27MP0001819_abnormal_immune_cell1.79692339
28MP0002419_abnormal_innate_immunity1.78544143
29MP0005025_abnormal_response_to1.77498643
30MP0002398_abnormal_bone_marrow1.76160908
31MP0005464_abnormal_platelet_physiology1.75414693
32MP0010155_abnormal_intestine_physiology1.67148399
33MP0005076_abnormal_cell_differentiation1.66610109
34MP0010307_abnormal_tumor_latency1.59680661
35MP0005409_darkened_coat_color1.56839421
36MP0000716_abnormal_immune_system1.55215114
37MP0002148_abnormal_hypersensitivity_rea1.53399821
38MP0002405_respiratory_system_inflammati1.51656042
39MP0005397_hematopoietic_system_phenotyp1.48911507
40MP0001545_abnormal_hematopoietic_system1.48911507
41MP0003724_increased_susceptibility_to1.48642634
42MP0009278_abnormal_bone_marrow1.48167515
43MP0003566_abnormal_cell_adhesion1.47977025
44MP0000465_gastrointestinal_hemorrhage1.47284323
45MP0001873_stomach_inflammation1.44676490
46MP0002722_abnormal_immune_system1.44128012
47MP0001853_heart_inflammation1.43314289
48MP0000689_abnormal_spleen_morphology1.42553720
49MP0001845_abnormal_inflammatory_respons1.41572520
50MP0002009_preneoplasia1.37214784
51MP0002429_abnormal_blood_cell1.35592019
52MP0004264_abnormal_extraembryonic_tissu1.34817934
53MP0000490_abnormal_crypts_of1.32802141
54MP0003693_abnormal_embryo_hatching1.28848343
55MP0009333_abnormal_splenocyte_physiolog1.28754383
56MP0003705_abnormal_hypodermis_morpholog1.27830664
57MP0004185_abnormal_adipocyte_glucose1.27346960
58MP0008260_abnormal_autophagy1.27091465
59MP0000703_abnormal_thymus_morphology1.25926344
60MP0004381_abnormal_hair_follicle1.22017970
61MP0003866_abnormal_defecation1.21479666
62MP0003183_abnormal_peptide_metabolism1.21196000
63MP0001533_abnormal_skeleton_physiology1.19529361
64MP0008057_abnormal_DNA_replication1.19006838
65MP0000858_altered_metastatic_potential1.16017201
66MP0003172_abnormal_lysosome_physiology1.13655315
67MP0000569_abnormal_digit_pigmentation1.13441454
68MP0003448_altered_tumor_morphology1.12188485
69MP0003221_abnormal_cardiomyocyte_apopto1.11687261
70MP0003453_abnormal_keratinocyte_physiol1.10562872
71MP0006082_CNS_inflammation1.09838037
72MP0003091_abnormal_cell_migration1.09540065
73MP0010094_abnormal_chromosome_stability1.08214548
74MP0005058_abnormal_lysosome_morphology1.06848823
75MP0005501_abnormal_skin_physiology1.06537530
76MP0010678_abnormal_skin_adnexa1.05396820
77MP0003890_abnormal_embryonic-extraembry1.04573264
78MP0005023_abnormal_wound_healing1.02227103
79MP0005310_abnormal_salivary_gland0.99584575
80MP0003191_abnormal_cellular_cholesterol0.98772648
81MP0008469_abnormal_protein_level0.98420516
82MP0002019_abnormal_tumor_incidence0.98220821
83MP0000383_abnormal_hair_follicle0.97660831
84MP0001730_embryonic_growth_arrest0.96252933
85MP0002138_abnormal_hepatobiliary_system0.96252174
86MP0003077_abnormal_cell_cycle0.96116828
87MP0004883_abnormal_blood_vessel0.94713398
88MP0001216_abnormal_epidermal_layer0.93997831
89MP0001879_abnormal_lymphatic_vessel0.90975735
90MP0005621_abnormal_cell_physiology0.88207003
91MP0003111_abnormal_nucleus_morphology0.87217087
92MP0002933_joint_inflammation0.85215528
93MP0003828_pulmonary_edema0.84821395
94MP0003943_abnormal_hepatobiliary_system0.84807236
95MP0003984_embryonic_growth_retardation0.84032346
96MP0002060_abnormal_skin_morphology0.83979276
97MP0002088_abnormal_embryonic_growth/wei0.82347151
98MP0005174_abnormal_tail_pigmentation0.81657410
99MP0004957_abnormal_blastocyst_morpholog0.81432100
100MP0000377_abnormal_hair_follicle0.81274620
101MP0002132_abnormal_respiratory_system0.80922156
102MP0003941_abnormal_skin_development0.80559061
103MP0002098_abnormal_vibrissa_morphology0.79474815
104MP0002998_abnormal_bone_remodeling0.79387855
105MP0003656_abnormal_erythrocyte_physiolo0.79370876
106MP0008007_abnormal_cellular_replicative0.79345736
107MP0002086_abnormal_extraembryonic_tissu0.77952189
108MP0002928_abnormal_bile_duct0.77698381
109MP0000371_diluted_coat_color0.77426427
110MP0003045_fibrosis0.73280970
111MP0001915_intracranial_hemorrhage0.73261902
112MP0001243_abnormal_dermal_layer0.73233549
113MP0004510_myositis0.73017778
114MP0002254_reproductive_system_inflammat0.72211022
115MP0009931_abnormal_skin_appearance0.71353013
116MP0001851_eye_inflammation0.71287234
117MP0000609_abnormal_liver_physiology0.71251593
118MP0003795_abnormal_bone_structure0.70609111
119MP0000350_abnormal_cell_proliferation0.70131738

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.06058549
2Recurrent viral infections (HP:0004429)3.62968203
3Papillary thyroid carcinoma (HP:0002895)3.39012375
4Recurrent abscess formation (HP:0002722)3.38346171
5Recurrent bacterial skin infections (HP:0005406)3.33984436
6Myositis (HP:0100614)3.29575937
7Recurrent fungal infections (HP:0002841)3.28590017
8Abnormality of the fingertips (HP:0001211)3.19677223
9Curly hair (HP:0002212)3.14916167
10Cellulitis (HP:0100658)3.11531419
11Ankyloglossia (HP:0010296)3.09097881
12IgM deficiency (HP:0002850)3.04933677
13Abnormal delayed hypersensitivity skin test (HP:0002963)2.90544353
14T lymphocytopenia (HP:0005403)2.89179739
15Elevated erythrocyte sedimentation rate (HP:0003565)2.87305002
16Orchitis (HP:0100796)2.86563536
17Abnormality of oral frenula (HP:0000190)2.85405495
18Spontaneous hematomas (HP:0007420)2.84960413
19Thrombocytosis (HP:0001894)2.79225978
20Abnormality of T cell number (HP:0011839)2.78959121
21Hematochezia (HP:0002573)2.73504508
22Retrobulbar optic neuritis (HP:0100654)2.70173404
23Optic neuritis (HP:0100653)2.70173404
24Meningitis (HP:0001287)2.67540710
25Arterial thrombosis (HP:0004420)2.67507824
26Autoimmune thrombocytopenia (HP:0001973)2.67264745
27Abnormality of T cells (HP:0002843)2.64002813
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.63029953
29Abnormality of T cell physiology (HP:0011840)2.61972395
30Periodontitis (HP:0000704)2.61952414
31Inflammation of the large intestine (HP:0002037)2.60521918
32Vasculitis (HP:0002633)2.55700876
33Gastrointestinal inflammation (HP:0004386)2.55405341
34Recurrent bronchitis (HP:0002837)2.54733298
35Colitis (HP:0002583)2.53210689
36Osteomyelitis (HP:0002754)2.51178076
37Abnormality of B cell number (HP:0010975)2.50610185
38B lymphocytopenia (HP:0010976)2.50610185
39Interstitial pulmonary disease (HP:0006530)2.49171398
40Right ventricular cardiomyopathy (HP:0011663)2.48812960
41Chronic otitis media (HP:0000389)2.47432635
42Agammaglobulinemia (HP:0004432)2.46824354
43Increased IgE level (HP:0003212)2.45563895
44Deep philtrum (HP:0002002)2.38678154
45Pustule (HP:0200039)2.38297267
46Recurrent gram-negative bacterial infections (HP:0005420)2.37142470
47Petechiae (HP:0000967)2.36734336
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.36636379
49Osteolytic defects of the hand bones (HP:0009699)2.36636379
50Volvulus (HP:0002580)2.36620481
51Thyroid carcinoma (HP:0002890)2.36423797
52Abnormality of nail color (HP:0100643)2.36298170
53Gastrointestinal infarctions (HP:0005244)2.36266200
54Thyroiditis (HP:0100646)2.35820333
55Abnormal platelet volume (HP:0011876)2.32710762
56Recurrent skin infections (HP:0001581)2.32345045
57Panhypogammaglobulinemia (HP:0003139)2.30631953
58Transitional cell carcinoma of the bladder (HP:0006740)2.28419303
59Chronic mucocutaneous candidiasis (HP:0002728)2.23387896
60Recurrent cutaneous fungal infections (HP:0011370)2.23387896
61Mediastinal lymphadenopathy (HP:0100721)2.23314740
62Eosinophilia (HP:0001880)2.23063221
63Bladder neoplasm (HP:0009725)2.22918173
64Bladder carcinoma (HP:0002862)2.22918173
65Verrucae (HP:0200043)2.21377131
66Papilloma (HP:0012740)2.21377131
67Chest pain (HP:0100749)2.21240001
68Thick nail (HP:0001805)2.21029754
69IgA deficiency (HP:0002720)2.20636383
70Acute myeloid leukemia (HP:0004808)2.19677032
71Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.19477956
72Prolonged bleeding time (HP:0003010)2.19279297
73Pulmonary infiltrates (HP:0002113)2.17783470
74Keratoconjunctivitis sicca (HP:0001097)2.17753678
75Gingival bleeding (HP:0000225)2.16864521
76Myocardial infarction (HP:0001658)2.16681693
77Obstructive lung disease (HP:0006536)2.13527334
78Chronic obstructive pulmonary disease (HP:0006510)2.13527334
79Urticaria (HP:0001025)2.13305787
80Flat acetabular roof (HP:0003180)2.13249473
81Abnormal platelet function (HP:0011869)2.12979773
82Impaired platelet aggregation (HP:0003540)2.12979773
83Lymphopenia (HP:0001888)2.11031801
84Leukocytosis (HP:0001974)2.10130575
85Viral hepatitis (HP:0006562)2.06829936
86Abnormality of cells of the lymphoid lineage (HP:0012140)2.05142097
87Subacute progressive viral hepatitis (HP:0006572)2.04472778
88Micronodular cirrhosis (HP:0001413)2.03134899
89Amaurosis fugax (HP:0100576)2.01675078
90Increased mean platelet volume (HP:0011877)2.01620497
91Epistaxis (HP:0000421)2.01369912
92Abnormality of macrophages (HP:0004311)1.99317691
93Encephalitis (HP:0002383)1.99149830
94Granulocytopenia (HP:0001913)1.99042228
95Nephroblastoma (Wilms tumor) (HP:0002667)1.98548614
96Skin ulcer (HP:0200042)1.98342020
97Malignant gastrointestinal tract tumors (HP:0006749)1.98335852
98Gastrointestinal carcinoma (HP:0002672)1.98335852
99Gingivitis (HP:0000230)1.96396562
100Asymmetry of the thorax (HP:0001555)1.95810306
101Leiomyosarcoma (HP:0100243)1.94916351
102Uterine leiomyosarcoma (HP:0002891)1.94916351
103Keratoconjunctivitis (HP:0001096)1.93175271
104Chronic diarrhea (HP:0002028)1.92120358
105Coarse hair (HP:0002208)1.90802527
106Embryonal renal neoplasm (HP:0011794)1.90548538
107Hemoptysis (HP:0002105)1.89507441
108Biliary tract neoplasm (HP:0100574)1.88281054
109Autoimmune hemolytic anemia (HP:0001890)1.88032326
110Hypoplasia of the thymus (HP:0000778)1.86543263
111Stomatitis (HP:0010280)1.86498811
112Neoplasm of the tracheobronchial system (HP:0100552)1.84197676
113Termporal pattern (HP:0011008)1.83335297
114Insidious onset (HP:0003587)1.83335297
115Abnormality of the prostate (HP:0008775)1.82263346
116Sepsis (HP:0100806)1.82225297
117Acanthocytosis (HP:0001927)1.76977397
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75588844
119Acute lymphatic leukemia (HP:0006721)1.74242366
120Vacuolated lymphocytes (HP:0001922)1.74148835
121Cheilitis (HP:0100825)1.73595534
122Combined immunodeficiency (HP:0005387)1.72606721
123Papilledema (HP:0001085)1.72439634
124Somatic mutation (HP:0001428)1.72200272
125Lymphoma (HP:0002665)1.71986992
126IgG deficiency (HP:0004315)1.71266868
127Lip pit (HP:0100267)1.70818235
128Nasal polyposis (HP:0100582)1.69749084
129Palmar hyperkeratosis (HP:0010765)1.69288122
130Sandal gap (HP:0001852)1.69275434
131Macroorchidism (HP:0000053)1.69252321
132Palmoplantar hyperkeratosis (HP:0000972)1.69172413
133Fatigue (HP:0012378)1.68859689
134Slow saccadic eye movements (HP:0000514)1.68657387
135Gastrointestinal stroma tumor (HP:0100723)1.68510992
136Plantar hyperkeratosis (HP:0007556)1.67907016
137Abnormality of eosinophils (HP:0001879)1.67703808
138Gangrene (HP:0100758)1.66792405
139Increased density of long bones (HP:0006392)1.66599648
140Pulmonary embolism (HP:0002204)1.66487364
141Blepharitis (HP:0000498)1.66370610
142Disinhibition (HP:0000734)1.65054475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K12.98140076
2EEF2K2.45808455
3TAOK32.39187707
4PRPF4B2.34788945
5STK102.33067216
6FRK2.15347231
7TYK22.04335506
8JAK32.02997801
9ERN12.01088141
10YES11.97765187
11MAP3K101.93326948
12CDK121.92589063
13IRAK41.82348393
14FGFR31.80435416
15BMPR21.78992796
16MAP3K141.75028182
17BTK1.68756900
18PKN21.68663317
19RPS6KA41.67358527
20ZAP701.65792099
21TGFBR21.60030397
22SIK31.55311535
23ITK1.54656642
24MST1R1.52915346
25TRIB31.52320672
26TXK1.51610869
27LRRK21.51420388
28IRAK31.51135650
29TEC1.50082243
30PTK61.47512128
31TBK11.47408443
32SCYL21.46508145
33MAP2K31.44715207
34CDK61.42712487
35JAK11.41634122
36EIF2AK11.34624131
37FGFR41.33285600
38GRK61.32989184
39PIM11.31307082
40MST41.29796463
41BLK1.29384016
42KSR21.28011146
43CSK1.23471289
44SMG11.22066248
45EPHB11.20094245
46FLT31.18297073
47RPS6KB21.18198392
48KIT1.17573081
49NEK91.15557555
50STK41.14508066
51STK31.14411766
52IKBKE1.12154709
53CHUK1.11756490
54SYK1.11375222
55TRPM71.09132222
56NEK21.07392602
57PASK1.06309514
58NLK1.05789325
59CSF1R1.04922271
60BRSK21.04863062
61IKBKB1.04378707
62MAP3K11.03270776
63MAP3K61.02282543
64CAMK1D1.01983390
65HIPK21.00701180
66MAP3K30.99977564
67CDC70.99962699
68FGR0.99757019
69SGK30.97955285
70WNK10.97814169
71EPHA30.96789843
72NUAK10.96497271
73KSR10.95745015
74JAK20.92856380
75IRAK10.92572413
76TGFBR10.92334996
77HCK0.91380142
78MARK30.90824864
79LCK0.90823860
80CDK40.89609804
81RIPK10.85112122
82CDK90.84087603
83MAP3K80.82259570
84TAF10.76050616
85LYN0.72772218
86TTK0.71886361
87CAMK1G0.70768866
88AKT30.69996029
89SGK20.69342704
90ICK0.68260608
91FES0.67736232
92CLK10.65994139
93PIK3CG0.64951889
94KDR0.64308196
95EIF2AK20.63630144
96ATR0.62719981
97RIPK40.61987819
98NEK60.59533684
99PAK40.59106322
100LATS10.58254844
101AURKB0.58158826
102DYRK1B0.58142415
103TTN0.58104652
104RET0.55998276
105MAP3K90.55499010
106SIK10.55028965
107MAPKAPK20.54701554
108PIM20.52142433
109ACVR1B0.51178913
110MELK0.50621543
111NME20.50319377
112BRD40.50222063
113MAPKAPK30.47979779
114MAPK110.47191526
115STK240.46963488
116MAP3K20.46845227
117PDGFRB0.46813966
118ALK0.46567099
119EGFR0.45465044
120TSSK60.45301692
121FGFR10.44763437
122MATK0.44366317
123IRAK20.43688012
124EPHA20.43018541
125EIF2AK30.42810729
126ATM0.40728908
127MTOR0.39333627
128RPS6KA60.38443796
129CDK70.38332786
130MAP3K130.37958425

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.39508728
2Primary immunodeficiency_Homo sapiens_hsa053402.37286177
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.26851778
4Antigen processing and presentation_Homo sapiens_hsa046122.16115985
5B cell receptor signaling pathway_Homo sapiens_hsa046622.04419662
6Osteoclast differentiation_Homo sapiens_hsa043801.95644064
7Measles_Homo sapiens_hsa051621.90931366
8Hematopoietic cell lineage_Homo sapiens_hsa046401.75990257
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.74624583
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67513971
11Herpes simplex infection_Homo sapiens_hsa051681.63434605
12Renal cell carcinoma_Homo sapiens_hsa052111.61504780
13Toxoplasmosis_Homo sapiens_hsa051451.61270324
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59914472
15Legionellosis_Homo sapiens_hsa051341.59235258
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56991389
17Chronic myeloid leukemia_Homo sapiens_hsa052201.51994422
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47207388
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.45931564
20Staphylococcus aureus infection_Homo sapiens_hsa051501.43511434
21Hepatitis B_Homo sapiens_hsa051611.38575452
22Small cell lung cancer_Homo sapiens_hsa052221.38283077
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.37728318
24Influenza A_Homo sapiens_hsa051641.34164613
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31643040
26Acute myeloid leukemia_Homo sapiens_hsa052211.29148092
27Apoptosis_Homo sapiens_hsa042101.28659352
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28580071
29Pancreatic cancer_Homo sapiens_hsa052121.28511739
30Viral carcinogenesis_Homo sapiens_hsa052031.28259967
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27817663
32Tuberculosis_Homo sapiens_hsa051521.25725363
33T cell receptor signaling pathway_Homo sapiens_hsa046601.23618726
34TNF signaling pathway_Homo sapiens_hsa046681.22173568
35Pertussis_Homo sapiens_hsa051331.21705802
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18838644
37Dorso-ventral axis formation_Homo sapiens_hsa043201.18101951
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11678086
39Shigellosis_Homo sapiens_hsa051311.11458014
40DNA replication_Homo sapiens_hsa030301.11325963
41Platelet activation_Homo sapiens_hsa046111.10939232
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.10328833
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.09361674
44Caffeine metabolism_Homo sapiens_hsa002321.08500494
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08092139
46p53 signaling pathway_Homo sapiens_hsa041151.07687626
47Viral myocarditis_Homo sapiens_hsa054161.05631583
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03361935
49Systemic lupus erythematosus_Homo sapiens_hsa053221.02853137
50Non-homologous end-joining_Homo sapiens_hsa034501.02845486
51Graft-versus-host disease_Homo sapiens_hsa053321.02072672
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02068095
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01428674
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00804693
55Malaria_Homo sapiens_hsa051440.99296406
56Chemokine signaling pathway_Homo sapiens_hsa040620.99264216
57MicroRNAs in cancer_Homo sapiens_hsa052060.97848241
58Cell cycle_Homo sapiens_hsa041100.97519100
59Hepatitis C_Homo sapiens_hsa051600.97417677
60ErbB signaling pathway_Homo sapiens_hsa040120.96884203
61HTLV-I infection_Homo sapiens_hsa051660.92364692
62Asthma_Homo sapiens_hsa053100.91988997
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.91687506
64Adherens junction_Homo sapiens_hsa045200.90443409
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88887094
66Allograft rejection_Homo sapiens_hsa053300.88798816
67Prostate cancer_Homo sapiens_hsa052150.88054249
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87681061
69Other glycan degradation_Homo sapiens_hsa005110.85917191
70Non-small cell lung cancer_Homo sapiens_hsa052230.85744734
71Prolactin signaling pathway_Homo sapiens_hsa049170.85425044
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85212663
73Insulin resistance_Homo sapiens_hsa049310.84511665
74Glioma_Homo sapiens_hsa052140.83764043
75Bladder cancer_Homo sapiens_hsa052190.82339037
76Choline metabolism in cancer_Homo sapiens_hsa052310.81184425
77Renin-angiotensin system_Homo sapiens_hsa046140.80562957
78Thyroid cancer_Homo sapiens_hsa052160.79982271
79One carbon pool by folate_Homo sapiens_hsa006700.79530514
80Lysosome_Homo sapiens_hsa041420.78758453
81Salmonella infection_Homo sapiens_hsa051320.77918061
82Lysine degradation_Homo sapiens_hsa003100.77688405
83Epstein-Barr virus infection_Homo sapiens_hsa051690.76335648
84mRNA surveillance pathway_Homo sapiens_hsa030150.75234928
85Base excision repair_Homo sapiens_hsa034100.74360534
86Proteoglycans in cancer_Homo sapiens_hsa052050.72963110
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72727660
88FoxO signaling pathway_Homo sapiens_hsa040680.72631498
89Selenocompound metabolism_Homo sapiens_hsa004500.71906448
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71786378
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.70276898
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.69834525
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67438531
94ABC transporters_Homo sapiens_hsa020100.65824843
95Amoebiasis_Homo sapiens_hsa051460.65499015
96N-Glycan biosynthesis_Homo sapiens_hsa005100.63182589
97Mismatch repair_Homo sapiens_hsa034300.62859336
98mTOR signaling pathway_Homo sapiens_hsa041500.61490957
99Insulin signaling pathway_Homo sapiens_hsa049100.60255816
100Colorectal cancer_Homo sapiens_hsa052100.60119319
101Focal adhesion_Homo sapiens_hsa045100.60002926
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56709307
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56416179
104Type II diabetes mellitus_Homo sapiens_hsa049300.54256670
105Notch signaling pathway_Homo sapiens_hsa043300.53614493
106Phagosome_Homo sapiens_hsa041450.53589682
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53031196
108Autoimmune thyroid disease_Homo sapiens_hsa053200.52415381
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52262318
110VEGF signaling pathway_Homo sapiens_hsa043700.51059059
111GnRH signaling pathway_Homo sapiens_hsa049120.50656216
112Endometrial cancer_Homo sapiens_hsa052130.50344240
113African trypanosomiasis_Homo sapiens_hsa051430.46397432
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45948407
115Complement and coagulation cascades_Homo sapiens_hsa046100.45358704
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45166249
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44985975
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.43022698
119Type I diabetes mellitus_Homo sapiens_hsa049400.42791726
120Inositol phosphate metabolism_Homo sapiens_hsa005620.42074060
121Pathways in cancer_Homo sapiens_hsa052000.41898450
122HIF-1 signaling pathway_Homo sapiens_hsa040660.41171205

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