PTCD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.79595517
2DNA deamination (GO:0045006)4.50121543
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24983815
4formation of translation preinitiation complex (GO:0001731)4.20545340
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.07686210
6ATP synthesis coupled proton transport (GO:0015986)4.07686210
7proteasome assembly (GO:0043248)3.99258800
8telomere maintenance via semi-conservative replication (GO:0032201)3.97180421
9DNA strand elongation involved in DNA replication (GO:0006271)3.94055077
10oxidative phosphorylation (GO:0006119)3.78778954
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.77323109
12protein-cofactor linkage (GO:0018065)3.75055193
13maturation of SSU-rRNA (GO:0030490)3.68851880
14DNA strand elongation (GO:0022616)3.68189741
15L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.64762398
16nucleobase biosynthetic process (GO:0046112)3.58496327
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.55237870
18DNA replication initiation (GO:0006270)3.54954693
19regulation of mitochondrial translation (GO:0070129)3.54950191
20maturation of 5.8S rRNA (GO:0000460)3.54497776
21viral transcription (GO:0019083)3.52700142
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.50750861
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50582854
24purine nucleobase biosynthetic process (GO:0009113)3.49029916
25translational termination (GO:0006415)3.48331787
26respiratory chain complex IV assembly (GO:0008535)3.47475851
27regulation of cellular amino acid metabolic process (GO:0006521)3.42111563
28ubiquinone metabolic process (GO:0006743)3.41951564
29somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41510299
30somatic hypermutation of immunoglobulin genes (GO:0016446)3.41510299
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40016656
32pseudouridine synthesis (GO:0001522)3.37936325
33negative regulation of ligase activity (GO:0051352)3.37854045
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37854045
35translational elongation (GO:0006414)3.36938810
36ribosomal large subunit biogenesis (GO:0042273)3.36548755
37tricarboxylic acid cycle (GO:0006099)3.36176071
38branched-chain amino acid catabolic process (GO:0009083)3.34156808
39telomere maintenance via recombination (GO:0000722)3.33317878
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28338145
41ribosomal small subunit biogenesis (GO:0042274)3.28253420
42NADH metabolic process (GO:0006734)3.26329533
43folic acid-containing compound biosynthetic process (GO:0009396)3.25103107
44protein deneddylation (GO:0000338)3.24242522
45metallo-sulfur cluster assembly (GO:0031163)3.24048824
46iron-sulfur cluster assembly (GO:0016226)3.24048824
47ribonucleoprotein complex biogenesis (GO:0022613)3.22518182
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22370609
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22370609
50amino acid salvage (GO:0043102)3.21813805
51L-methionine salvage (GO:0071267)3.21813805
52L-methionine biosynthetic process (GO:0071265)3.21813805
53ribosome biogenesis (GO:0042254)3.21187507
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19955382
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19219686
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19219686
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19219686
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18798734
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.18798734
60NADH dehydrogenase complex assembly (GO:0010257)3.18798734
61translational initiation (GO:0006413)3.18733328
62DNA unwinding involved in DNA replication (GO:0006268)3.18557738
63viral mRNA export from host cell nucleus (GO:0046784)3.17526189
64mitochondrial respiratory chain complex assembly (GO:0033108)3.14302077
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14199724
66peptidyl-histidine modification (GO:0018202)3.14087830
67DNA double-strand break processing (GO:0000729)3.13927468
68signal transduction involved in DNA damage checkpoint (GO:0072422)3.13061750
69signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13061750
70protein complex biogenesis (GO:0070271)3.11731699
71cytochrome complex assembly (GO:0017004)3.10177003
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10060431
73methionine biosynthetic process (GO:0009086)3.09385111
74cullin deneddylation (GO:0010388)3.08865014
75translation (GO:0006412)3.08767603
76signal transduction involved in cell cycle checkpoint (GO:0072395)3.08730592
77recombinational repair (GO:0000725)3.06432771
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06214168
79cellular component biogenesis (GO:0044085)3.04489508
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04001328
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04001328
82cotranslational protein targeting to membrane (GO:0006613)3.03515054
83DNA replication checkpoint (GO:0000076)3.03481883
84rRNA processing (GO:0006364)3.03235566
85double-strand break repair via homologous recombination (GO:0000724)3.02321817
86pyrimidine dimer repair (GO:0006290)3.02148116
87mitochondrial RNA metabolic process (GO:0000959)3.01978439
88protein K6-linked ubiquitination (GO:0085020)3.01694444
89antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.01054384
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99322337
91protein targeting to ER (GO:0045047)2.98694635
92telomere maintenance via telomere lengthening (GO:0010833)2.98171487
93mitotic recombination (GO:0006312)2.98100570
94kynurenine metabolic process (GO:0070189)2.98043369
95IMP biosynthetic process (GO:0006188)2.97895305
96termination of RNA polymerase III transcription (GO:0006386)2.95026232
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.95026232
98preassembly of GPI anchor in ER membrane (GO:0016254)2.94400401
99CENP-A containing nucleosome assembly (GO:0034080)2.93381477
100positive regulation of ligase activity (GO:0051351)2.93198283
101rRNA metabolic process (GO:0016072)2.92741704
102cellular ketone body metabolic process (GO:0046950)2.92689908
103quinone biosynthetic process (GO:1901663)2.92305275
104ubiquinone biosynthetic process (GO:0006744)2.92305275
105mannosylation (GO:0097502)2.92254755
106rRNA modification (GO:0000154)2.92169059
107behavioral response to nicotine (GO:0035095)2.90703360
108respiratory electron transport chain (GO:0022904)2.89366292
109protein localization to endoplasmic reticulum (GO:0070972)2.88166466
110G1/S transition of mitotic cell cycle (GO:0000082)2.87422564
111cell cycle G1/S phase transition (GO:0044843)2.87422564
112water-soluble vitamin biosynthetic process (GO:0042364)2.85875501
113chromatin remodeling at centromere (GO:0031055)2.85793470
114replication fork processing (GO:0031297)2.84938960
115regulation of mitotic spindle checkpoint (GO:1903504)2.84525789
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84525789
117IMP metabolic process (GO:0046040)2.84369230
118electron transport chain (GO:0022900)2.84233842
119postreplication repair (GO:0006301)2.83281682
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81827527
121spliceosomal snRNP assembly (GO:0000387)2.81735232
122establishment of protein localization to endoplasmic reticulum (GO:0072599)2.81688619
123nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81673323
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.81074257
125tRNA processing (GO:0008033)2.80808460
126indolalkylamine metabolic process (GO:0006586)2.80088612
127regulation of hexokinase activity (GO:1903299)2.79903120
128regulation of glucokinase activity (GO:0033131)2.79903120
129rRNA catabolic process (GO:0016075)2.79373590
130rRNA methylation (GO:0031167)2.79221865
131tRNA metabolic process (GO:0006399)2.79036029
132cellular protein complex disassembly (GO:0043624)2.78932301
133aerobic respiration (GO:0009060)2.78511442
134somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.77027363
135isotype switching (GO:0045190)2.77027363
136somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.77027363
137transcription elongation from RNA polymerase I promoter (GO:0006362)2.76782296
138amino acid activation (GO:0043038)2.75568893
139tRNA aminoacylation (GO:0043039)2.75568893
140aspartate family amino acid catabolic process (GO:0009068)2.74939947
141branched-chain amino acid metabolic process (GO:0009081)2.74699175
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.74599669
143regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.73678622
144tryptophan metabolic process (GO:0006568)2.72456590
145attachment of spindle microtubules to kinetochore (GO:0008608)2.68821722
146regulation of cilium movement (GO:0003352)2.67293274
147mismatch repair (GO:0006298)2.66701020
148DNA catabolic process, exonucleolytic (GO:0000738)2.65793588
149reciprocal DNA recombination (GO:0035825)2.64833945
150reciprocal meiotic recombination (GO:0007131)2.64833945
151tRNA modification (GO:0006400)2.64506814
152detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60429338
153negative regulation of DNA-dependent DNA replication (GO:2000104)2.60406510
154aspartate family amino acid biosynthetic process (GO:0009067)2.60333246
155regulation of centriole replication (GO:0046599)2.60222008
156ketone body metabolic process (GO:1902224)2.58399103
157indole-containing compound catabolic process (GO:0042436)2.57407966
158indolalkylamine catabolic process (GO:0046218)2.57407966
159tryptophan catabolic process (GO:0006569)2.57407966
160negative regulation of telomere maintenance (GO:0032205)2.56039730
161sulfur amino acid biosynthetic process (GO:0000097)2.55774607
162DNA excision (GO:0044349)2.54728238
163nucleotide-excision repair, DNA damage removal (GO:0000718)2.54728238
164lysine metabolic process (GO:0006553)2.53946435
165lysine catabolic process (GO:0006554)2.53946435
166histone H2A acetylation (GO:0043968)2.52312868
167somatic diversification of immunoglobulins (GO:0016445)2.50128044
168S-adenosylmethionine metabolic process (GO:0046500)2.49133924
169DNA-dependent DNA replication (GO:0006261)2.48699807
170tRNA aminoacylation for protein translation (GO:0006418)2.48177282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.25072478
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.28423469
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.13894273
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.90901021
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.61199017
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.44500175
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.40624171
8ZNF274_21170338_ChIP-Seq_K562_Hela3.27504507
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.22004198
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00864522
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00061029
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98992948
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98202528
14VDR_22108803_ChIP-Seq_LS180_Human2.91209841
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80139806
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70727249
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65666685
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59529777
19VDR_23849224_ChIP-Seq_CD4+_Human2.51901757
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51867911
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.41901035
22FUS_26573619_Chip-Seq_HEK293_Human2.41256758
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35317647
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34788976
25EWS_26573619_Chip-Seq_HEK293_Human2.34172305
26FOXP3_21729870_ChIP-Seq_TREG_Human2.30155581
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28931523
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25967982
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25148657
30DCP1A_22483619_ChIP-Seq_HELA_Human2.24752147
31TAF15_26573619_Chip-Seq_HEK293_Human2.24438204
32XRN2_22483619_ChIP-Seq_HELA_Human2.23399900
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22744096
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.22511010
35IGF1R_20145208_ChIP-Seq_DFB_Human2.22269918
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19731527
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15867799
38THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12721828
39GABP_19822575_ChIP-Seq_HepG2_Human2.07845901
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05623136
41FLI1_27457419_Chip-Seq_LIVER_Mouse2.05014329
42ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01924243
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.99552369
44GBX2_23144817_ChIP-Seq_PC3_Human1.98682479
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97007073
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96387552
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93796382
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92112352
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92069412
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85134928
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84499096
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.79641302
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74309702
54* TTF2_22483619_ChIP-Seq_HELA_Human1.71376050
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63175781
56* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62804400
57P300_19829295_ChIP-Seq_ESCs_Human1.60482080
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59421235
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58100694
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57972927
61CIITA_25753668_ChIP-Seq_RAJI_Human1.57762920
62* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57538795
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56580494
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55805872
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54654488
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.53990436
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52726470
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52221399
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51957177
70ELK1_19687146_ChIP-ChIP_HELA_Human1.50712290
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49639696
72* TP53_22573176_ChIP-Seq_HFKS_Human1.49247501
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47273094
74AR_21909140_ChIP-Seq_LNCAP_Human1.47025624
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46542572
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44925017
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42841800
78ER_23166858_ChIP-Seq_MCF-7_Human1.42597940
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42438034
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38640323
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38510168
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37507781
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37492174
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36384095
85KDM5A_27292631_Chip-Seq_BREAST_Human1.35208548
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34785282
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34613303
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.31623889
89IRF1_19129219_ChIP-ChIP_H3396_Human1.30683451
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30245075
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28933408
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28331739
93CBP_20019798_ChIP-Seq_JUKART_Human1.28331739
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26333350
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26189900
96* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22218099
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22150681
98MYC_22102868_ChIP-Seq_BL_Human1.20811478
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20731438
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19945488
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16023706
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15989840
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15732529
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15476637
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14803332
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13735045
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13222379
108STAT3_23295773_ChIP-Seq_U87_Human1.12382153
109SPI1_23547873_ChIP-Seq_NB4_Human1.12121164
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11474675
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11299347
112MYC_18940864_ChIP-ChIP_HL60_Human1.09946083
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08439703
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08316077
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07069634
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04014666
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.02755844
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02582705
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01893990
120TCF4_23295773_ChIP-Seq_U87_Human1.01891389
121* SMAD4_21799915_ChIP-Seq_A2780_Human1.01781053
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.99845874
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99583869
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.96593477
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96175070
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.96088682
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96032121
128NANOG_19829295_ChIP-Seq_ESCs_Human0.95940004
129SOX2_19829295_ChIP-Seq_ESCs_Human0.95940004
130TCF4_22108803_ChIP-Seq_LS180_Human0.95936867
131KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94931463
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94249572
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93740187
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92479494
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92440836
136* AR_20517297_ChIP-Seq_VCAP_Human0.92285048
137AR_25329375_ChIP-Seq_VCAP_Human0.91363028
138FOXA1_25329375_ChIP-Seq_VCAP_Human0.91303696
139FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91303696
140TFEB_21752829_ChIP-Seq_HELA_Human0.90346582
141IRF8_21731497_ChIP-ChIP_J774_Mouse0.89981945
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89033274
143FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88731457
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88419231
145TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88112826
146CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87155913
147DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87097678
148ELK1_22589737_ChIP-Seq_MCF10A_Human0.87007032
149* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86707352
150MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86493450
151* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86104643
152GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84642413
153* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84624240
154EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79864551
155STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79355593
156HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78164325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.49868365
2MP0003693_abnormal_embryo_hatching4.17367930
3MP0004957_abnormal_blastocyst_morpholog3.38555775
4MP0010094_abnormal_chromosome_stability3.17898402
5* MP0006036_abnormal_mitochondrial_physio3.03319887
6MP0003111_abnormal_nucleus_morphology2.90898426
7MP0002396_abnormal_hematopoietic_system2.86711200
8MP0003077_abnormal_cell_cycle2.66666607
9MP0003646_muscle_fatigue2.49148713
10MP0004147_increased_porphyrin_level2.46656549
11MP0002837_dystrophic_cardiac_calcinosis2.35953879
12MP0008057_abnormal_DNA_replication2.35618758
13MP0008058_abnormal_DNA_repair2.34240235
14MP0006072_abnormal_retinal_apoptosis2.27712711
15MP0004084_abnormal_cardiac_muscle2.18974615
16* MP0006035_abnormal_mitochondrial_morpho2.12789128
17MP0002938_white_spotting2.11772215
18MP0003763_abnormal_thymus_physiology2.06376960
19MP0002102_abnormal_ear_morphology2.05850909
20MP0005551_abnormal_eye_electrophysiolog2.05076192
21MP0001835_abnormal_antigen_presentation2.03645700
22MP0009379_abnormal_foot_pigmentation2.02188338
23MP0004145_abnormal_muscle_electrophysio2.00430461
24MP0009697_abnormal_copulation1.96162986
25MP0003186_abnormal_redox_activity1.91279398
26MP0006292_abnormal_olfactory_placode1.90417714
27MP0005085_abnormal_gallbladder_physiolo1.89738476
28MP0002736_abnormal_nociception_after1.89686300
29MP0001764_abnormal_homeostasis1.76050583
30MP0002139_abnormal_hepatobiliary_system1.73547260
31MP0000569_abnormal_digit_pigmentation1.73432659
32MP0001968_abnormal_touch/_nociception1.71061258
33MP0003136_yellow_coat_color1.70547218
34MP0005360_urolithiasis1.69477502
35MP0008875_abnormal_xenobiotic_pharmacok1.66105783
36MP0008932_abnormal_embryonic_tissue1.65419794
37MP0005253_abnormal_eye_physiology1.64598737
38MP0003880_abnormal_central_pattern1.64589108
39MP0008007_abnormal_cellular_replicative1.62244022
40MP0004215_abnormal_myocardial_fiber1.59940702
41MP0000490_abnormal_crypts_of1.58973819
42MP0009785_altered_susceptibility_to1.57906961
43MP0003656_abnormal_erythrocyte_physiolo1.55912799
44MP0003221_abnormal_cardiomyocyte_apopto1.51899529
45MP0000372_irregular_coat_pigmentation1.50064110
46MP0003123_paternal_imprinting1.47757063
47MP0009046_muscle_twitch1.44992628
48MP0001730_embryonic_growth_arrest1.44629085
49MP0005365_abnormal_bile_salt1.43801623
50MP0004133_heterotaxia1.43434555
51MP0002398_abnormal_bone_marrow1.42427400
52MP0000689_abnormal_spleen_morphology1.42110875
53MP0009333_abnormal_splenocyte_physiolog1.41985922
54MP0005671_abnormal_response_to1.41834497
55MP0000631_abnormal_neuroendocrine_gland1.36189777
56MP0003718_maternal_effect1.36128027
57MP0008872_abnormal_physiological_respon1.36072483
58MP0001661_extended_life_span1.35739655
59MP0005319_abnormal_enzyme/_coenzyme1.35223187
60MP0000749_muscle_degeneration1.35216861
61MP0005332_abnormal_amino_acid1.34645039
62MP0004043_abnormal_pH_regulation1.34208882
63MP0010352_gastrointestinal_tract_polyps1.32716900
64MP0001853_heart_inflammation1.31448621
65MP0000685_abnormal_immune_system1.31271211
66MP0002722_abnormal_immune_system1.30670852
67MP0004036_abnormal_muscle_relaxation1.30504978
68MP0003567_abnormal_fetal_cardiomyocyte1.29976669
69* MP0000358_abnormal_cell_content/1.29840541
70MP0005266_abnormal_metabolism1.28981809
71MP0005645_abnormal_hypothalamus_physiol1.28871954
72MP0002019_abnormal_tumor_incidence1.27618595
73MP0000313_abnormal_cell_death1.27305789
74MP0003950_abnormal_plasma_membrane1.26612057
75MP0002160_abnormal_reproductive_system1.25033049
76MP0002269_muscular_atrophy1.24917335
77MP0005330_cardiomyopathy1.22798430
78MP0005646_abnormal_pituitary_gland1.21078313
79MP0002429_abnormal_blood_cell1.18856363
80MP0000350_abnormal_cell_proliferation1.17958007
81MP0003937_abnormal_limbs/digits/tail_de1.17823921
82MP0003890_abnormal_embryonic-extraembry1.17620599
83MP0001986_abnormal_taste_sensitivity1.17108085
84MP0001800_abnormal_humoral_immune1.16087442
85MP0001293_anophthalmia1.15942955
86MP0004142_abnormal_muscle_tone1.15221178
87MP0000427_abnormal_hair_cycle1.14100774
88MP0000716_abnormal_immune_system1.12101680
89MP0003195_calcinosis1.10725076
90MP0002132_abnormal_respiratory_system1.08833649
91MP0002272_abnormal_nervous_system1.07199205
92MP0003786_premature_aging1.06944300
93MP0005025_abnormal_response_to1.05674260
94MP0008877_abnormal_DNA_methylation1.05202210
95MP0002234_abnormal_pharynx_morphology1.04836361
96MP0000015_abnormal_ear_pigmentation1.03872017
97MP0001929_abnormal_gametogenesis1.01898640
98MP0002420_abnormal_adaptive_immunity1.01816109
99MP0002095_abnormal_skin_pigmentation1.01663846
100MP0001819_abnormal_immune_cell1.00719002
101MP0009745_abnormal_behavioral_response1.00447473
102MP0001984_abnormal_olfaction1.00068679
103MP0000703_abnormal_thymus_morphology0.99443732
104MP0008260_abnormal_autophagy0.97976514
105MP0009840_abnormal_foam_cell0.97973281
106MP0002080_prenatal_lethality0.97904714
107MP0005584_abnormal_enzyme/coenzyme_acti0.97791665
108MP0005187_abnormal_penis_morphology0.97089084
109MP0002127_abnormal_cardiovascular_syste0.96438224
110MP0002723_abnormal_immune_serum0.95832289
111MP0002138_abnormal_hepatobiliary_system0.95572851
112MP0003121_genomic_imprinting0.95093625
113MP0002452_abnormal_antigen_presenting0.94814434
114MP0002751_abnormal_autonomic_nervous0.93422276
115MP0008469_abnormal_protein_level0.93198970
116MP0004134_abnormal_chest_morphology0.92622908
117MP0008775_abnormal_heart_ventricle0.91502225
118MP0005075_abnormal_melanosome_morpholog0.90393236
119MP0002163_abnormal_gland_morphology0.90240365
120MP0008789_abnormal_olfactory_epithelium0.90195831
121MP0001486_abnormal_startle_reflex0.89946472
122MP0001529_abnormal_vocalization0.88904701
123MP0003787_abnormal_imprinting0.87468362
124MP0002210_abnormal_sex_determination0.87022648
125MP0003984_embryonic_growth_retardation0.85587631
126MP0001697_abnormal_embryo_size0.85361206
127MP0001545_abnormal_hematopoietic_system0.85179640
128MP0005397_hematopoietic_system_phenotyp0.85179640
129MP0000751_myopathy0.85122355
130MP0005174_abnormal_tail_pigmentation0.84800589
131* MP0000598_abnormal_liver_morphology0.84395699
132MP0002928_abnormal_bile_duct0.84159547
133MP0000653_abnormal_sex_gland0.82521602
134MP0000647_abnormal_sebaceous_gland0.82192239
135MP0001544_abnormal_cardiovascular_syste0.81603651
136MP0005385_cardiovascular_system_phenoty0.81603651
137MP0003252_abnormal_bile_duct0.81249557
138MP0002148_abnormal_hypersensitivity_rea0.79806238
139MP0000609_abnormal_liver_physiology0.79643220
140MP0003698_abnormal_male_reproductive0.79618385
141MP0005380_embryogenesis_phenotype0.79459185
142MP0001672_abnormal_embryogenesis/_devel0.79459185
143MP0005195_abnormal_posterior_eye0.79218966
144MP0002088_abnormal_embryonic_growth/wei0.78551660
145MP0002653_abnormal_ependyma_morphology0.78433986
146MP0008873_increased_physiological_sensi0.78325283
147MP0005636_abnormal_mineral_homeostasis0.78228265
148MP0001485_abnormal_pinna_reflex0.78172461
149MP0005171_absent_coat_pigmentation0.78035363
150MP0006276_abnormal_autonomic_nervous0.77619239
151MP0008995_early_reproductive_senescence0.76883940
152MP0002090_abnormal_vision0.76722309
153MP0005391_vision/eye_phenotype0.76468010
154MP0005084_abnormal_gallbladder_morpholo0.76247793
155MP0005376_homeostasis/metabolism_phenot0.76087961
156MP0001145_abnormal_male_reproductive0.74714093
157MP0005389_reproductive_system_phenotype0.74279473
158MP0002067_abnormal_sensory_capabilities0.74273600
159MP0002876_abnormal_thyroid_physiology0.72961346
160MP0002752_abnormal_somatic_nervous0.72608486
161MP0002572_abnormal_emotion/affect_behav0.71650615
162MP0001501_abnormal_sleep_pattern0.71384169
163MP0001905_abnormal_dopamine_level0.70485123
164MP0009250_abnormal_appendicular_skeleto0.69338321

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.59132508
2Hepatic necrosis (HP:0002605)4.56376786
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.27498867
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.27498867
5Mitochondrial inheritance (HP:0001427)4.10742521
6Abnormal mitochondria in muscle tissue (HP:0008316)4.08825461
7Increased CSF lactate (HP:0002490)4.03347629
8Acute necrotizing encephalopathy (HP:0006965)3.97320559
9Pancreatic cysts (HP:0001737)3.87545309
10Increased serum lactate (HP:0002151)3.80783323
11Abnormality of cells of the erythroid lineage (HP:0012130)3.70077682
12Pancreatic fibrosis (HP:0100732)3.68324458
13Lactic acidosis (HP:0003128)3.67410107
14Acute encephalopathy (HP:0006846)3.67215885
15Abnormality of alanine metabolism (HP:0010916)3.63490083
16Hyperalaninemia (HP:0003348)3.63490083
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.63490083
18Microvesicular hepatic steatosis (HP:0001414)3.54079921
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.52963564
20Increased serum pyruvate (HP:0003542)3.52068541
21Abnormality of glycolysis (HP:0004366)3.52068541
22Birth length less than 3rd percentile (HP:0003561)3.50205221
23Increased intramyocellular lipid droplets (HP:0012240)3.43458891
24Lipid accumulation in hepatocytes (HP:0006561)3.43006318
25Abnormal number of erythroid precursors (HP:0012131)3.42770033
26Increased muscle lipid content (HP:0009058)3.39764669
27Increased hepatocellular lipid droplets (HP:0006565)3.31345296
28Ragged-red muscle fibers (HP:0003200)3.30670894
29Aplastic anemia (HP:0001915)3.27456035
30Cerebral edema (HP:0002181)3.26681575
31Progressive macrocephaly (HP:0004481)3.11836173
32True hermaphroditism (HP:0010459)3.11152897
33Exercise intolerance (HP:0003546)3.10803189
34Oral leukoplakia (HP:0002745)3.05971994
35Nephronophthisis (HP:0000090)3.00316878
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.96662618
37IgM deficiency (HP:0002850)2.94686780
383-Methylglutaconic aciduria (HP:0003535)2.91425231
39Methylmalonic acidemia (HP:0002912)2.88224729
40Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87602269
41Dicarboxylic aciduria (HP:0003215)2.87602269
42Medial flaring of the eyebrow (HP:0010747)2.87213946
43Exertional dyspnea (HP:0002875)2.82149438
44Thrombocytosis (HP:0001894)2.82138485
45Abnormality of midbrain morphology (HP:0002418)2.80464710
46Molar tooth sign on MRI (HP:0002419)2.80464710
47Respiratory difficulties (HP:0002880)2.80183882
48Rhabdomyolysis (HP:0003201)2.80031655
49Reticulocytopenia (HP:0001896)2.79588645
50Hyperammonemia (HP:0001987)2.70441877
51Abnormality of fatty-acid metabolism (HP:0004359)2.65465646
52Progressive muscle weakness (HP:0003323)2.64386481
53Respiratory failure (HP:0002878)2.63209378
54Breast hypoplasia (HP:0003187)2.60867572
55Renal Fanconi syndrome (HP:0001994)2.58656330
56Lethargy (HP:0001254)2.55374180
57Abnormality of the renal cortex (HP:0011035)2.53857929
58Abnormality of the renal medulla (HP:0100957)2.50572504
59CNS demyelination (HP:0007305)2.49378927
60Myoglobinuria (HP:0002913)2.48691086
61Chromsome breakage (HP:0040012)2.48162851
62Emotional lability (HP:0000712)2.46338796
63Abnormality of the heme biosynthetic pathway (HP:0010472)2.45951513
64Generalized aminoaciduria (HP:0002909)2.44966032
65Palpitations (HP:0001962)2.44126767
66Pancytopenia (HP:0001876)2.41885230
67Gait imbalance (HP:0002141)2.39993545
68Type II lissencephaly (HP:0007260)2.39886051
69Multiple enchondromatosis (HP:0005701)2.38763707
70Congenital stationary night blindness (HP:0007642)2.38032878
71Congenital primary aphakia (HP:0007707)2.37459863
72Renal cortical cysts (HP:0000803)2.36400734
73Aplasia/Hypoplasia of the tongue (HP:0010295)2.33685956
74Microretrognathia (HP:0000308)2.32427218
75Abnormality of serum amino acid levels (HP:0003112)2.30944659
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30891140
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.28775814
78Type I transferrin isoform profile (HP:0003642)2.28312668
79Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.28041525
80Abnormality of pyrimidine metabolism (HP:0004353)2.27703233
81Nausea (HP:0002018)2.26236718
82Chronic hepatic failure (HP:0100626)2.21767705
83Macrocytic anemia (HP:0001972)2.21053982
84Hyperglycinemia (HP:0002154)2.20184579
85Abnormality of the ileum (HP:0001549)2.19877938
86Progressive inability to walk (HP:0002505)2.19752307
87Meckel diverticulum (HP:0002245)2.19744816
88Attenuation of retinal blood vessels (HP:0007843)2.18421894
89Large for gestational age (HP:0001520)2.18398643
90Abnormality of chromosome stability (HP:0003220)2.18364322
91Cerebral hypomyelination (HP:0006808)2.17922374
92Nephrogenic diabetes insipidus (HP:0009806)2.16944409
93IgG deficiency (HP:0004315)2.16730548
94Abnormality of the pons (HP:0007361)2.11672279
95Hypobetalipoproteinemia (HP:0003563)2.11436047
96Hyperglycinuria (HP:0003108)2.09662913
97Colon cancer (HP:0003003)2.05547899
98Sclerocornea (HP:0000647)2.04828073
99Abnormality of serine family amino acid metabolism (HP:0010894)2.01956765
100Abnormality of glycine metabolism (HP:0010895)2.01956765
101Abnormal biliary tract physiology (HP:0012439)2.01045836
102Bile duct proliferation (HP:0001408)2.01045836
103Postaxial foot polydactyly (HP:0001830)2.00962721
104Tubular atrophy (HP:0000092)2.00959807
105Abnormality of the labia minora (HP:0012880)2.00720858
106Aplasia/Hypoplasia of the tibia (HP:0005772)1.99548930
107Pallor (HP:0000980)1.98318901
108Anencephaly (HP:0002323)1.97129719
109Cystic liver disease (HP:0006706)1.97123338
110Agnosia (HP:0010524)1.95813265
111Congenital hepatic fibrosis (HP:0002612)1.94728904
112Abnormality of urine glucose concentration (HP:0011016)1.94273103
113Glycosuria (HP:0003076)1.94273103
114Unsteady gait (HP:0002317)1.93709208
115Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92673917
116Methylmalonic aciduria (HP:0012120)1.92067129
117Patellar aplasia (HP:0006443)1.91695530
118Absent thumb (HP:0009777)1.91251446
119Genital tract atresia (HP:0001827)1.89264953
120Recurrent bronchitis (HP:0002837)1.88733448
121Inability to walk (HP:0002540)1.88440516
122Gliosis (HP:0002171)1.86122843
123Reduced antithrombin III activity (HP:0001976)1.85955590
124Sloping forehead (HP:0000340)1.85680336
125Hypoglycemic coma (HP:0001325)1.85250853
126Cerebellar dysplasia (HP:0007033)1.83120885
127Metabolic acidosis (HP:0001942)1.81460366
128Gaze-evoked nystagmus (HP:0000640)1.81227904
129Exercise-induced muscle cramps (HP:0003710)1.81098393
130Abolished electroretinogram (ERG) (HP:0000550)1.79752932
131Neoplasm of the adrenal gland (HP:0100631)1.79606552
132Abnormality of DNA repair (HP:0003254)1.79274114
133Duplicated collecting system (HP:0000081)1.78278402
134Ketoacidosis (HP:0001993)1.78010861
135Ketosis (HP:0001946)1.77694544
136Vaginal atresia (HP:0000148)1.77566144
137Leukodystrophy (HP:0002415)1.76656196
138Abnormality of T cell physiology (HP:0011840)1.76432596
139Postaxial hand polydactyly (HP:0001162)1.75715138
140Central scotoma (HP:0000603)1.75234344
141Degeneration of anterior horn cells (HP:0002398)1.74410558
142Abnormality of the anterior horn cell (HP:0006802)1.74410558
143Poor coordination (HP:0002370)1.74339752
144Abnormality of the preputium (HP:0100587)1.74226455
145Muscle fiber atrophy (HP:0100295)1.74100104
146Hyperventilation (HP:0002883)1.73822818
147Preaxial hand polydactyly (HP:0001177)1.73649944
148Tubulointerstitial nephritis (HP:0001970)1.73035208
149Aplasia/Hypoplasia of the patella (HP:0006498)1.72057730
150Glioma (HP:0009733)1.71478301
151Hypoplasia of the pons (HP:0012110)1.71077148
152Type 2 muscle fiber atrophy (HP:0003554)1.70969550
153Abnormality of the renal collecting system (HP:0004742)1.70768658
154Optic disc pallor (HP:0000543)1.70192166
155Abnormal protein glycosylation (HP:0012346)1.69711753
156Abnormal glycosylation (HP:0012345)1.69711753
157Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69711753
158Abnormal protein N-linked glycosylation (HP:0012347)1.69711753
159Entropion (HP:0000621)1.68209656
160Megaloblastic anemia (HP:0001889)1.66993718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.34811354
2BUB14.20225319
3FRK4.03017493
4WEE13.18563420
5NEK13.12199120
6MAP4K23.11510760
7MAP3K123.01035425
8EIF2AK32.89751274
9STK162.77381197
10NME22.71506147
11BCKDK2.70012075
12NUAK12.62730399
13ARAF2.61337370
14ACVR1B2.61249196
15CDC72.60121935
16TSSK62.18335934
17BMPR1B2.13333266
18FLT32.12249320
19VRK12.09939643
20PNCK1.99034552
21MKNK21.93031750
22WNK41.88745148
23CCNB11.85182109
24PIM21.83506757
25BRAF1.77240331
26MYLK1.75226131
27GRK11.73350776
28PDK41.60275336
29PDK31.60275336
30MAP4K11.58435367
31MAPK131.56296105
32NEK21.52759954
33MAPKAPK51.44195909
34BRSK21.43478048
35PLK41.41863756
36VRK21.40758900
37MAP3K41.39761182
38TRIM281.38863210
39ZAK1.33280167
40PLK11.26171038
41TESK21.24990753
42PHKG11.24757195
43PHKG21.24757195
44OXSR11.22797919
45MAP3K111.19702608
46TYK21.13171482
47SRPK11.12732136
48KIT1.11328950
49PLK21.09277123
50NME11.08806152
51RPS6KB21.08023852
52DAPK11.07325390
53PLK31.05297614
54STK391.04416851
55BRSK11.04259869
56TTK1.03752022
57AKT31.02763027
58TXK1.02688869
59ILK1.02161205
60TNIK1.00127345
61MAP2K30.99029365
62TLK10.99002321
63ZAP700.97893159
64BCR0.96009860
65ATR0.95791264
66OBSCN0.95271021
67STK38L0.94847327
68CDK190.94232991
69AURKB0.92860847
70PBK0.91702183
71KDR0.91547968
72AURKA0.91469289
73STK240.89067436
74CSNK1G10.88104148
75MST40.87372013
76INSRR0.87038487
77CSNK1A1L0.83851564
78TGFBR10.83829199
79ERBB30.82764411
80MAP2K70.82156415
81CASK0.81096230
82GRK60.80638127
83DYRK30.79570213
84MAP2K60.79181890
85CAMKK20.78427794
86PASK0.73824306
87CSNK1G20.73544503
88PKN20.72558976
89WNK30.70592376
90JAK30.69886472
91TAOK30.69598751
92ATM0.69028671
93DYRK20.68591053
94BTK0.67696721
95CDK80.66565137
96CSNK2A10.65133274
97SCYL20.64917302
98CDK40.64315557
99CSF1R0.64033136
100SYK0.63619043
101MAPKAPK30.63551438
102RPS6KA50.63395042
103TEC0.63269772
104PINK10.62057776
105RAF10.60503707
106CSNK2A20.59536788
107PRKCE0.56539597
108PAK30.54662093
109RPS6KA60.54616198
110PIM10.53837397
111EIF2AK20.53555064
112ADRBK10.53388209
113MAP3K80.53002017
114PRKCG0.52921993
115IRAK40.51805434
116RPS6KC10.51680241
117RPS6KL10.51680241
118MAP2K40.51324995
119MKNK10.49033031
120CDK70.48747271
121MUSK0.47033252
122TAF10.46750625
123MAPK110.44841140
124MAP3K50.44290598
125PIK3CA0.44216614
126CHEK10.44067263
127CSNK1A10.43198355
128BRD40.41897590
129CAMK2A0.41702747
130TESK10.41571450
131PAK10.41225969
132PAK40.40265110
133ADRBK20.39755580
134STK40.39268322
135EPHA40.39021275
136CDK30.38570525
137MAPK150.38546090
138CLK10.36521723
139NEK90.36469659
140PRKCQ0.36458301
141RPS6KA40.36149308
142ERBB40.35898135
143DAPK30.34935334
144NTRK30.34874056
145LATS10.33937467
146PDK20.32474549
147ABL20.31008866
148CSNK1G30.30634958
149TAOK20.30622738
150NLK0.29401591
151CHEK20.29217726
152IKBKB0.28986033
153EEF2K0.28720738
154LYN0.28375211
155MAPKAPK20.27894800

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.00824534
2DNA replication_Homo sapiens_hsa030303.79274431
3Ribosome_Homo sapiens_hsa030103.45447901
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.17728698
5Mismatch repair_Homo sapiens_hsa034303.12931829
6RNA polymerase_Homo sapiens_hsa030202.66779267
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.55738132
8Parkinsons disease_Homo sapiens_hsa050122.50878508
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50529618
10Oxidative phosphorylation_Homo sapiens_hsa001902.44965225
11Base excision repair_Homo sapiens_hsa034102.30738223
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27587812
13Pyrimidine metabolism_Homo sapiens_hsa002402.21015581
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03657017
15Homologous recombination_Homo sapiens_hsa034402.03227343
16Spliceosome_Homo sapiens_hsa030402.03104448
17Nucleotide excision repair_Homo sapiens_hsa034201.94999489
18Carbon metabolism_Homo sapiens_hsa012001.90944910
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85291865
20Biosynthesis of amino acids_Homo sapiens_hsa012301.84168420
21RNA transport_Homo sapiens_hsa030131.81803261
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75718506
23One carbon pool by folate_Homo sapiens_hsa006701.72588556
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.69925106
25Huntingtons disease_Homo sapiens_hsa050161.68647419
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65740344
27Phototransduction_Homo sapiens_hsa047441.56845037
28Pyruvate metabolism_Homo sapiens_hsa006201.52526144
29Propanoate metabolism_Homo sapiens_hsa006401.48462567
30RNA degradation_Homo sapiens_hsa030181.47528797
31Pentose phosphate pathway_Homo sapiens_hsa000301.45154638
32Folate biosynthesis_Homo sapiens_hsa007901.43774977
33Nitrogen metabolism_Homo sapiens_hsa009101.43214204
34Alzheimers disease_Homo sapiens_hsa050101.40396165
35Cell cycle_Homo sapiens_hsa041101.39647470
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38188114
37Protein export_Homo sapiens_hsa030601.33104081
38Purine metabolism_Homo sapiens_hsa002301.27006196
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26670149
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.26200856
41Linoleic acid metabolism_Homo sapiens_hsa005911.25491972
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21891644
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19803891
44Fructose and mannose metabolism_Homo sapiens_hsa000511.15245647
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14443955
46Non-homologous end-joining_Homo sapiens_hsa034501.14145248
47Fatty acid degradation_Homo sapiens_hsa000711.12982681
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11551857
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05909644
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05520451
51Basal transcription factors_Homo sapiens_hsa030221.05463923
52Nicotine addiction_Homo sapiens_hsa050331.03881539
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02444638
54Fanconi anemia pathway_Homo sapiens_hsa034600.94750593
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92495556
56Selenocompound metabolism_Homo sapiens_hsa004500.92120148
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90576670
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87969860
59Sulfur relay system_Homo sapiens_hsa041220.85887676
60Fatty acid elongation_Homo sapiens_hsa000620.85821818
61Primary immunodeficiency_Homo sapiens_hsa053400.84907460
62Peroxisome_Homo sapiens_hsa041460.84773226
63Ether lipid metabolism_Homo sapiens_hsa005650.84622928
64Steroid biosynthesis_Homo sapiens_hsa001000.83959311
65Cardiac muscle contraction_Homo sapiens_hsa042600.82008921
66Olfactory transduction_Homo sapiens_hsa047400.78829046
67Epstein-Barr virus infection_Homo sapiens_hsa051690.76737174
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.76229345
69Taste transduction_Homo sapiens_hsa047420.74589518
70Lysine degradation_Homo sapiens_hsa003100.73804574
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.73140720
72Metabolic pathways_Homo sapiens_hsa011000.72617033
73Circadian rhythm_Homo sapiens_hsa047100.69815205
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69432282
75Galactose metabolism_Homo sapiens_hsa000520.68343036
76Vitamin B6 metabolism_Homo sapiens_hsa007500.66395777
77p53 signaling pathway_Homo sapiens_hsa041150.66357591
78Tryptophan metabolism_Homo sapiens_hsa003800.64848430
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.60484245
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59441322
81Glutathione metabolism_Homo sapiens_hsa004800.58661065
82Regulation of autophagy_Homo sapiens_hsa041400.57962931
83Antigen processing and presentation_Homo sapiens_hsa046120.57279967
84Fatty acid metabolism_Homo sapiens_hsa012120.55635562
85beta-Alanine metabolism_Homo sapiens_hsa004100.52602412
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.52462021
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51107878
88mRNA surveillance pathway_Homo sapiens_hsa030150.47776179
89Phenylalanine metabolism_Homo sapiens_hsa003600.47706915
90Caffeine metabolism_Homo sapiens_hsa002320.47468323
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47233000
92Herpes simplex infection_Homo sapiens_hsa051680.47147063
93Butanoate metabolism_Homo sapiens_hsa006500.44019400
94Systemic lupus erythematosus_Homo sapiens_hsa053220.43312882
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.42838572
96Allograft rejection_Homo sapiens_hsa053300.41933263
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40007794
98Arginine and proline metabolism_Homo sapiens_hsa003300.39952306
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39607845
100Tyrosine metabolism_Homo sapiens_hsa003500.38983602
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38487762
102Arginine biosynthesis_Homo sapiens_hsa002200.37353061
103Legionellosis_Homo sapiens_hsa051340.35324600
104Retinol metabolism_Homo sapiens_hsa008300.34722027
105Hedgehog signaling pathway_Homo sapiens_hsa043400.34694265
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33188463
107ABC transporters_Homo sapiens_hsa020100.31792703
108Morphine addiction_Homo sapiens_hsa050320.30487902
109Arachidonic acid metabolism_Homo sapiens_hsa005900.28960948
110Calcium signaling pathway_Homo sapiens_hsa040200.26969848
111Sulfur metabolism_Homo sapiens_hsa009200.25599892
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25324125
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24811411
114Starch and sucrose metabolism_Homo sapiens_hsa005000.23720948
115Basal cell carcinoma_Homo sapiens_hsa052170.22849791
116Circadian entrainment_Homo sapiens_hsa047130.22773167
117Chemical carcinogenesis_Homo sapiens_hsa052040.21515028
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21493833
119N-Glycan biosynthesis_Homo sapiens_hsa005100.21432306
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20722671
121Viral carcinogenesis_Homo sapiens_hsa052030.19763723
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16221474
123Oocyte meiosis_Homo sapiens_hsa041140.16155261
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14603024
125Measles_Homo sapiens_hsa051620.14442323
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12547749
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11645161

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