PTCH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)8.10507676
2regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.95680523
3prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.90077113
4mesenchymal-epithelial cell signaling (GO:0060638)5.70269321
5planar cell polarity pathway involved in neural tube closure (GO:0090179)5.14971850
6craniofacial suture morphogenesis (GO:0097094)5.14068907
7bone trabecula formation (GO:0060346)4.94026975
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.92150600
9presynaptic membrane assembly (GO:0097105)4.86201304
10regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.69421862
11neuronal stem cell maintenance (GO:0097150)4.52286135
12mesenchymal cell proliferation (GO:0010463)4.32483177
13presynaptic membrane organization (GO:0097090)4.32176373
14branching involved in prostate gland morphogenesis (GO:0060442)4.24904441
15radial glial cell differentiation (GO:0060019)4.22209137
16regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.21059072
17axon ensheathment in central nervous system (GO:0032291)4.20387272
18central nervous system myelination (GO:0022010)4.20387272
19branching involved in salivary gland morphogenesis (GO:0060445)4.16955421
20regulation of non-canonical Wnt signaling pathway (GO:2000050)4.14298187
21postsynaptic membrane organization (GO:0001941)4.11955749
22digestive tract morphogenesis (GO:0048546)4.06487745
23negative regulation of catenin import into nucleus (GO:0035414)4.00275598
24convergent extension (GO:0060026)3.88299366
25anatomical structure regression (GO:0060033)3.85995056
26cranial suture morphogenesis (GO:0060363)3.85968389
27negative regulation of osteoblast proliferation (GO:0033689)3.81738395
28NLS-bearing protein import into nucleus (GO:0006607)3.71569249
29artery smooth muscle contraction (GO:0014824)3.70081955
30head development (GO:0060322)3.67587957
31Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.63178467
32branching involved in labyrinthine layer morphogenesis (GO:0060670)3.63071275
33forebrain neuron differentiation (GO:0021879)3.61008762
34dorsal/ventral axis specification (GO:0009950)3.58612313
35neuron cell-cell adhesion (GO:0007158)3.56662366
36regulation of establishment of planar polarity (GO:0090175)3.55886984
37tonic smooth muscle contraction (GO:0014820)3.52826640
38G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.50380320
39prostate gland epithelium morphogenesis (GO:0060740)3.49897256
40appendage development (GO:0048736)3.49190421
41limb development (GO:0060173)3.49190421
42cell-cell signaling involved in cell fate commitment (GO:0045168)3.45881909
43proximal/distal pattern formation (GO:0009954)3.43041727
44heart valve formation (GO:0003188)3.38096063
45dendritic spine morphogenesis (GO:0060997)3.37951124
46cranial nerve development (GO:0021545)3.36450358
47tongue development (GO:0043586)3.33445321
48paraxial mesoderm development (GO:0048339)3.30711909
49axis elongation (GO:0003401)3.29868493
50limb bud formation (GO:0060174)3.27741853
51negative regulation of oligodendrocyte differentiation (GO:0048715)3.22320094
52notochord development (GO:0030903)3.20715824
53non-canonical Wnt signaling pathway (GO:0035567)3.19489032
54axonal fasciculation (GO:0007413)3.19362806
55dermatan sulfate biosynthetic process (GO:0030208)3.18216393
56lung-associated mesenchyme development (GO:0060484)3.18104376
57cochlea development (GO:0090102)3.17517624
58otic vesicle formation (GO:0030916)3.17300078
59enteric nervous system development (GO:0048484)3.17208525
60sequestering of extracellular ligand from receptor (GO:0035581)3.17171975
61nephron tubule morphogenesis (GO:0072078)3.16735065
62nephron epithelium morphogenesis (GO:0072088)3.16735065
63neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.16295877
64vocalization behavior (GO:0071625)3.14678273
65* regulation of smoothened signaling pathway (GO:0008589)3.13299094
66negative regulation of glial cell differentiation (GO:0045686)3.11781100
67midbrain development (GO:0030901)3.10068363
68peripheral nervous system axon ensheathment (GO:0032292)3.09252143
69myelination in peripheral nervous system (GO:0022011)3.09252143
70embryonic hindlimb morphogenesis (GO:0035116)3.09095562
71developmental induction (GO:0031128)3.08449646
72neuronal ion channel clustering (GO:0045161)3.05543276
73endocardial cushion morphogenesis (GO:0003203)3.05029128
74* negative regulation of smoothened signaling pathway (GO:0045879)3.04303562
75behavioral response to nicotine (GO:0035095)3.02203239
76somatic stem cell division (GO:0048103)3.00071367
77negative regulation of translation, ncRNA-mediated (GO:0040033)2.99477088
78regulation of translation, ncRNA-mediated (GO:0045974)2.99477088
79negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99477088
80mesenchyme morphogenesis (GO:0072132)2.98989856
81polarized epithelial cell differentiation (GO:0030859)2.96962344
82negative regulation of astrocyte differentiation (GO:0048712)2.94640227
83negative regulation of chondrocyte differentiation (GO:0032331)2.93125545
84branch elongation of an epithelium (GO:0060602)2.89878956
85* hindlimb morphogenesis (GO:0035137)2.88829093
86midgut development (GO:0007494)2.88457421
87auditory behavior (GO:0031223)2.88257855
88dermatan sulfate metabolic process (GO:0030205)2.87032405
89regulation of catenin import into nucleus (GO:0035412)2.86944854
90glomerulus development (GO:0032835)2.85059262
91regulation of morphogenesis of a branching structure (GO:0060688)2.84704958
92gamma-aminobutyric acid transport (GO:0015812)2.84258627
93neuronal action potential propagation (GO:0019227)2.83616552
94neuroblast proliferation (GO:0007405)2.82448611
95lung epithelium development (GO:0060428)2.82383667
96genitalia morphogenesis (GO:0035112)2.82368898
97hindbrain development (GO:0030902)2.80701935
98nephron tubule formation (GO:0072079)2.80631299
99establishment of planar polarity (GO:0001736)2.79768534
100establishment of tissue polarity (GO:0007164)2.79768534
101epithelial cell differentiation involved in prostate gland development (GO:0060742)2.79426727
102negative regulation of fibroblast apoptotic process (GO:2000270)2.78923885
103organ induction (GO:0001759)2.78537611
104positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.77420242
105hair follicle morphogenesis (GO:0031069)2.76817524
106mechanosensory behavior (GO:0007638)2.76692192
107retinal ganglion cell axon guidance (GO:0031290)2.76586002
108negative regulation of inclusion body assembly (GO:0090084)2.76110694
109epithelial tube branching involved in lung morphogenesis (GO:0060441)2.75404892
110pyrimidine nucleobase catabolic process (GO:0006208)2.75056595
111nonmotile primary cilium assembly (GO:0035058)2.74842751
112lens fiber cell development (GO:0070307)2.71938698
113organ formation (GO:0048645)2.71676161
114regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.68844882
115vascular smooth muscle contraction (GO:0014829)2.67557852
116hippo signaling (GO:0035329)2.66653465
117neuron fate determination (GO:0048664)2.65186690
118sodium ion export (GO:0071436)2.65102151
119cochlea morphogenesis (GO:0090103)2.64725078
120insulin-like growth factor receptor signaling pathway (GO:0048009)2.63949136
121positive regulation of smoothened signaling pathway (GO:0045880)2.63739724
122mesodermal cell differentiation (GO:0048333)2.63566562
123regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62821448
124spinal cord development (GO:0021510)2.62315294
125cytoplasmic mRNA processing body assembly (GO:0033962)2.61819691
126epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.61569654
127cranial nerve morphogenesis (GO:0021602)2.60627100
128negative regulation of JUN kinase activity (GO:0043508)2.59973385
129neuron recognition (GO:0008038)2.59463589
130kidney morphogenesis (GO:0060993)2.59417141
131organ growth (GO:0035265)2.59374315
132cell surface receptor signaling pathway involved in heart development (GO:0061311)2.58928155
133morphogenesis of an epithelial fold (GO:0060571)2.58108045
134mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.57479261
135mesenchymal cell differentiation (GO:0048762)2.57353872
136positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.57305177
137thalamus development (GO:0021794)2.56535352
138chondrocyte development (GO:0002063)2.56426265
139transmission of nerve impulse (GO:0019226)2.55929806
140type B pancreatic cell development (GO:0003323)2.55775849
141detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55202628
142regulation of oligodendrocyte differentiation (GO:0048713)2.54375217
143positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52688468
144negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.52426880
145membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51654636
146outer ear morphogenesis (GO:0042473)2.50915926
147regulation of gene silencing by RNA (GO:0060966)2.50474584
148regulation of posttranscriptional gene silencing (GO:0060147)2.50474584
149regulation of gene silencing by miRNA (GO:0060964)2.50474584
150glial cell migration (GO:0008347)2.50197148
151regulation of osteoblast proliferation (GO:0033688)2.49200643
152chondroitin sulfate catabolic process (GO:0030207)2.48597688
153pituitary gland development (GO:0021983)2.48240748
154positive regulation of mesenchymal cell proliferation (GO:0002053)2.47722416
155positive regulation of synapse assembly (GO:0051965)2.47668577
156embryonic digestive tract morphogenesis (GO:0048557)2.47334934
157regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47274698
158regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47157547
159regulation of mesenchymal cell proliferation (GO:0010464)2.46968745
160regulation of keratinocyte proliferation (GO:0010837)2.46687460
161locomotory exploration behavior (GO:0035641)2.44820481
162photoreceptor cell differentiation (GO:0046530)2.44507964
163eye photoreceptor cell differentiation (GO:0001754)2.44507964
164collecting duct development (GO:0072044)2.44332711
165central nervous system projection neuron axonogenesis (GO:0021952)2.44322423
166mitotic sister chromatid cohesion (GO:0007064)2.44010671
167regulation of heart morphogenesis (GO:2000826)2.43918373
168neuromuscular synaptic transmission (GO:0007274)2.43884526
169establishment of nucleus localization (GO:0040023)2.43880980
170regulation of timing of cell differentiation (GO:0048505)2.42560973
171apical protein localization (GO:0045176)2.42494771
172renal tubule morphogenesis (GO:0061333)2.41813468
173lung lobe morphogenesis (GO:0060463)2.41439116
174regulation of chondrocyte differentiation (GO:0032330)2.41428606
175somatic stem cell maintenance (GO:0035019)2.40473171
176central nervous system neuron axonogenesis (GO:0021955)2.40126178
177response to auditory stimulus (GO:0010996)2.38716143
178regulation of development, heterochronic (GO:0040034)2.37078992
179ovulation cycle (GO:0042698)2.35890343
180neurotransmitter-gated ion channel clustering (GO:0072578)2.34959203
181ectodermal placode formation (GO:0060788)2.34273066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.13268198
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.56597425
3EED_16625203_ChIP-ChIP_MESCs_Mouse2.61038773
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.48241016
5EZH2_22144423_ChIP-Seq_EOC_Human2.39361541
6AR_21572438_ChIP-Seq_LNCaP_Human2.38004537
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33771542
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26807759
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26179671
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26179671
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.19656417
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16473515
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16402210
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13855331
15RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06550043
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.05683195
17GBX2_23144817_ChIP-Seq_PC3_Human2.03513684
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.03183974
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01563894
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95822086
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95254618
22* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.94808717
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91661636
24* RNF2_27304074_Chip-Seq_ESCs_Mouse1.88143398
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.86799973
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86629554
27* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.84863947
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83735992
29* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.82848816
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.81839170
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81591187
32DROSHA_22980978_ChIP-Seq_HELA_Human1.78626242
33* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76800631
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76443311
35RNF2_27304074_Chip-Seq_NSC_Mouse1.76362315
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73509971
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73509971
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73509971
39* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.68662288
40* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.68423204
41* REST_21632747_ChIP-Seq_MESCs_Mouse1.67614003
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66762986
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64868365
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59796140
45DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.57608787
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56391911
47* ISL1_27105846_Chip-Seq_CPCs_Mouse1.55793347
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47502006
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.47024817
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.46940127
51* RING1B_27294783_Chip-Seq_NPCs_Mouse1.45288005
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44211783
53ZNF274_21170338_ChIP-Seq_K562_Hela1.43882118
54* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43548873
55VDR_22108803_ChIP-Seq_LS180_Human1.43015958
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42772986
57* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40970164
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40655366
59AHR_22903824_ChIP-Seq_MCF-7_Human1.37714823
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36292695
61SMAD4_21799915_ChIP-Seq_A2780_Human1.36068649
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35301568
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34570179
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34522476
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.33890191
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33786887
67* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33285868
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33197017
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32833869
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31882518
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31731355
72* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30981687
73* RING1B_27294783_Chip-Seq_ESCs_Mouse1.30819948
74* EZH2_27294783_Chip-Seq_ESCs_Mouse1.30637927
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30449206
76* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29999908
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29770578
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.29419386
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29197455
80* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27806386
81RXR_22108803_ChIP-Seq_LS180_Human1.26747110
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24546257
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.24497227
84TAF15_26573619_Chip-Seq_HEK293_Human1.23695893
85* AR_19668381_ChIP-Seq_PC3_Human1.20895780
86* EWS_26573619_Chip-Seq_HEK293_Human1.20206094
87TP53_16413492_ChIP-PET_HCT116_Human1.19992163
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19582365
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19323775
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.19022836
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.18635884
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.17354280
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16517349
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15899873
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15659522
96STAT3_23295773_ChIP-Seq_U87_Human1.15125212
97AR_25329375_ChIP-Seq_VCAP_Human1.15079095
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13316324
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13316324
100* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12926360
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11125131
102REST_18959480_ChIP-ChIP_MESCs_Mouse1.10200764
103EP300_21415370_ChIP-Seq_HL-1_Mouse1.09449589
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.09024270
105* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08708340
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.08150815
107* P300_19829295_ChIP-Seq_ESCs_Human1.07604039
108TRIM28_21343339_ChIP-Seq_HEK293_Human1.07130784
109* SOX9_26525672_Chip-Seq_HEART_Mouse1.06951787
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.06635759
111WDR5_24793694_ChIP-Seq_LNCAP_Human1.06095928
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05951776
113SMAD3_21741376_ChIP-Seq_ESCs_Human1.05932311
114BCAT_22108803_ChIP-Seq_LS180_Human1.05216789
115* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04964572
116TP53_18474530_ChIP-ChIP_U2OS_Human1.04404092
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04254525
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03993726
119IGF1R_20145208_ChIP-Seq_DFB_Human1.03887514
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01900592
121GATA1_26923725_Chip-Seq_HPCs_Mouse1.00845427
122* KDM2B_26808549_Chip-Seq_K562_Human1.00786012
123* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00524672
124TCF4_23295773_ChIP-Seq_U87_Human0.99046439
125* RUNX2_22187159_ChIP-Seq_PCA_Human0.98484086
126FUS_26573619_Chip-Seq_HEK293_Human0.98017230
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97931966
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.97499176
129STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95935979
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93608609
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93082558
132* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93025635
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.91952587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.57293088
2MP0010030_abnormal_orbit_morphology3.24520278
3MP0004272_abnormal_basement_membrane2.81206893
4MP0005248_abnormal_Harderian_gland2.73066926
5MP0000537_abnormal_urethra_morphology2.72663652
6MP0001293_anophthalmia2.66052220
7MP0009379_abnormal_foot_pigmentation2.60214598
8MP0009250_abnormal_appendicular_skeleto2.55452900
9* MP0002938_white_spotting2.55123359
10MP0001485_abnormal_pinna_reflex2.28772851
11MP0003385_abnormal_body_wall2.20324450
12* MP0001299_abnormal_eye_distance/2.14703819
13* MP0000428_abnormal_craniofacial_morphol2.13731284
14MP0003122_maternal_imprinting2.11676261
15* MP0005187_abnormal_penis_morphology2.11665190
16MP0002282_abnormal_trachea_morphology2.10262875
17MP0003942_abnormal_urinary_system2.07003100
18MP0004885_abnormal_endolymph2.06790973
19MP0003880_abnormal_central_pattern2.03531891
20MP0005171_absent_coat_pigmentation2.01852992
21MP0000579_abnormal_nail_morphology1.99639463
22MP0003878_abnormal_ear_physiology1.98799265
23MP0005377_hearing/vestibular/ear_phenot1.98799265
24MP0000462_abnormal_digestive_system1.97390073
25MP0003937_abnormal_limbs/digits/tail_de1.94638574
26MP0009053_abnormal_anal_canal1.91048860
27MP0003935_abnormal_craniofacial_develop1.87669256
28MP0001661_extended_life_span1.81879554
29MP0003755_abnormal_palate_morphology1.77824874
30MP0002089_abnormal_postnatal_growth/wei1.76277224
31MP0000762_abnormal_tongue_morphology1.70141312
32MP0000049_abnormal_middle_ear1.65748644
33* MP0002116_abnormal_craniofacial_bone1.60327102
34MP0002638_abnormal_pupillary_reflex1.57075634
35MP0003136_yellow_coat_color1.55882146
36MP0003115_abnormal_respiratory_system1.55506910
37MP0002249_abnormal_larynx_morphology1.55219745
38MP0000026_abnormal_inner_ear1.51863893
39MP0000534_abnormal_ureter_morphology1.51031685
40MP0002064_seizures1.48549790
41MP0003121_genomic_imprinting1.45851642
42MP0003705_abnormal_hypodermis_morpholog1.44031265
43MP0003938_abnormal_ear_development1.43654947
44* MP0000432_abnormal_head_morphology1.43523246
45MP0000569_abnormal_digit_pigmentation1.43488433
46MP0009745_abnormal_behavioral_response1.42929300
47MP0000778_abnormal_nervous_system1.42006974
48MP0001188_hyperpigmentation1.41472186
49MP0001177_atelectasis1.37397698
50MP0002063_abnormal_learning/memory/cond1.35999062
51MP0004270_analgesia1.34191198
52MP0000427_abnormal_hair_cycle1.33087804
53* MP0002108_abnormal_muscle_morphology1.32890028
54MP0002822_catalepsy1.32843420
55MP0005257_abnormal_intraocular_pressure1.31616593
56MP0004742_abnormal_vestibular_system1.31272267
57MP0006292_abnormal_olfactory_placode1.31116840
58MP0002272_abnormal_nervous_system1.30157593
59* MP0002572_abnormal_emotion/affect_behav1.29840994
60MP0002734_abnormal_mechanical_nocicepti1.28848984
61MP0009384_cardiac_valve_regurgitation1.28094181
62MP0002557_abnormal_social/conspecific_i1.26520383
63MP0002092_abnormal_eye_morphology1.25850252
64* MP0002109_abnormal_limb_morphology1.25041778
65MP0009780_abnormal_chondrocyte_physiolo1.24905324
66* MP0002932_abnormal_joint_morphology1.24060036
67MP0003123_paternal_imprinting1.23679617
68MP0002233_abnormal_nose_morphology1.23299931
69MP0003941_abnormal_skin_development1.22901710
70MP0001346_abnormal_lacrimal_gland1.22620495
71MP0001340_abnormal_eyelid_morphology1.18990224
72MP0005646_abnormal_pituitary_gland1.18723533
73* MP0003861_abnormal_nervous_system1.16922543
74MP0003283_abnormal_digestive_organ1.16462678
75MP0002067_abnormal_sensory_capabilities1.16239433
76MP0001984_abnormal_olfaction1.16158989
77MP0009703_decreased_birth_body1.14790883
78MP0000733_abnormal_muscle_development1.13434411
79MP0002184_abnormal_innervation1.13431169
80MP0002098_abnormal_vibrissa_morphology1.12371093
81MP0001502_abnormal_circadian_rhythm1.11997307
82MP0003119_abnormal_digestive_system1.11341310
83MP0005367_renal/urinary_system_phenotyp1.10100107
84MP0000516_abnormal_urinary_system1.10100107
85MP0001529_abnormal_vocalization1.09903636
86MP0002177_abnormal_outer_ear1.09081717
87MP0002751_abnormal_autonomic_nervous1.08639194
88MP0004142_abnormal_muscle_tone1.07854553
89MP0005174_abnormal_tail_pigmentation1.07729805
90MP0000383_abnormal_hair_follicle1.07472916
91MP0001963_abnormal_hearing_physiology1.07192201
92MP0009046_muscle_twitch1.04964149
93MP0002928_abnormal_bile_duct1.04909120
94MP0000955_abnormal_spinal_cord1.04731405
95* MP0002882_abnormal_neuron_morphology1.04043130
96MP0005551_abnormal_eye_electrophysiolog1.02832828
97MP0002752_abnormal_somatic_nervous1.01912485
98MP0002277_abnormal_respiratory_mucosa1.00962978
99* MP0005508_abnormal_skeleton_morphology1.00926021
100MP0001968_abnormal_touch/_nociception1.00838183
101* MP0000163_abnormal_cartilage_morphology1.00019123
102MP0002735_abnormal_chemical_nociception0.99737840
103MP0005253_abnormal_eye_physiology0.99689584
104MP0005391_vision/eye_phenotype0.99219346
105* MP0000647_abnormal_sebaceous_gland0.97407983
106MP0002653_abnormal_ependyma_morphology0.96861549
107MP0003632_abnormal_nervous_system0.96848157
108MP0005623_abnormal_meninges_morphology0.96140403
109MP0000631_abnormal_neuroendocrine_gland0.95401221
110MP0002697_abnormal_eye_size0.95116211
111MP0005076_abnormal_cell_differentiation0.94101456
112MP0008569_lethality_at_weaning0.93614046
113MP0001958_emphysema0.93231221
114MP0002736_abnormal_nociception_after0.93195197
115MP0000751_myopathy0.92450960
116* MP0002115_abnormal_skeleton_extremities0.92384775
117* MP0004197_abnormal_fetal_growth/weight/0.91241598
118MP0004858_abnormal_nervous_system0.90996302
119* MP0002114_abnormal_axial_skeleton0.90906700
120MP0000639_abnormal_adrenal_gland0.90850383
121MP0010368_abnormal_lymphatic_system0.90697783
122MP0008438_abnormal_cutaneous_collagen0.90647109
123* MP0002085_abnormal_embryonic_tissue0.90304098
124MP0001486_abnormal_startle_reflex0.90179893
125* MP0005503_abnormal_tendon_morphology0.89791921
126MP0010678_abnormal_skin_adnexa0.89746885
127MP0004859_abnormal_synaptic_plasticity0.89404002
128MP0001286_abnormal_eye_development0.88619079
129MP0002733_abnormal_thermal_nociception0.87771354
130MP0001270_distended_abdomen0.86086854
131MP0004133_heterotaxia0.86050067
132MP0001970_abnormal_pain_threshold0.85805353
133MP0002084_abnormal_developmental_patter0.85206635
134MP0005645_abnormal_hypothalamus_physiol0.85151870
135MP0003635_abnormal_synaptic_transmissio0.84015323
136MP0002081_perinatal_lethality0.83309221
137MP0002009_preneoplasia0.83094700
138MP0001501_abnormal_sleep_pattern0.81715229
139MP0003890_abnormal_embryonic-extraembry0.80685044
140MP0002234_abnormal_pharynx_morphology0.80611099
141MP0006072_abnormal_retinal_apoptosis0.79911735
142MP0003787_abnormal_imprinting0.79507911
143MP0005220_abnormal_exocrine_pancreas0.79187146
144* MP0002152_abnormal_brain_morphology0.79106941
145MP0002102_abnormal_ear_morphology0.78703710
146MP0004233_abnormal_muscle_weight0.78584962
147MP0005423_abnormal_somatic_nervous0.77414237

Predicted human phenotypes

RankGene SetZ-score
1* Short 4th metacarpal (HP:0010044)4.77711359
2* Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.77711359
3* Abnormality of the parietal bone (HP:0002696)4.66518028
4* Midline defect of the nose (HP:0004122)4.42960102
5Anteriorly placed anus (HP:0001545)4.06069050
6* Trigonocephaly (HP:0000243)3.95186081
7Broad metatarsal (HP:0001783)3.82000491
8Septo-optic dysplasia (HP:0100842)3.78252766
9Esophageal atresia (HP:0002032)3.78025362
10Aplasia involving bones of the extremities (HP:0009825)3.67903021
11Aplasia involving bones of the upper limbs (HP:0009823)3.67903021
12Aplasia of the phalanges of the hand (HP:0009802)3.67903021
13Shallow orbits (HP:0000586)3.67537456
14Split foot (HP:0001839)3.56672551
15Nasolacrimal duct obstruction (HP:0000579)3.53258676
16* Abnormality of the 4th metacarpal (HP:0010012)3.51510723
17Gastrointestinal atresia (HP:0002589)3.44677026
18Intestinal atresia (HP:0011100)3.33244481
19Alacrima (HP:0000522)3.29522478
20Vitreoretinal degeneration (HP:0000655)3.23554235
21Coronal craniosynostosis (HP:0004440)3.19969802
22Abnormality of the lacrimal duct (HP:0011481)3.08088702
23Abnormality of the nasolacrimal system (HP:0000614)2.99184963
24Focal motor seizures (HP:0011153)2.94393194
25Turricephaly (HP:0000262)2.85084364
26* Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.85022424
27Abnormality of the labia minora (HP:0012880)2.78478910
28Anophthalmia (HP:0000528)2.72397631
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.72048386
30Narrow palate (HP:0000189)2.71380817
31Synostosis involving the elbow (HP:0003938)2.70366208
32Humeroradial synostosis (HP:0003041)2.70366208
33* Abnormality of the diencephalon (HP:0010662)2.68755348
34Optic nerve hypoplasia (HP:0000609)2.67990718
35Broad toe (HP:0001837)2.67899032
36Microglossia (HP:0000171)2.67336792
37Partial duplication of the phalanx of hand (HP:0009999)2.66769942
38Exostoses (HP:0100777)2.65604035
39Decreased lacrimation (HP:0000633)2.64748864
40Maternal diabetes (HP:0009800)2.60293737
41Broad hallux (HP:0010055)2.54200324
42Partial duplication of thumb phalanx (HP:0009944)2.52115936
43Aqueductal stenosis (HP:0002410)2.51829573
44Hypoplastic labia majora (HP:0000059)2.48151984
45Oligodactyly (hands) (HP:0001180)2.47178974
46Aplasia/Hypoplasia of the sternum (HP:0006714)2.45710627
47Fibular hypoplasia (HP:0003038)2.44469835
48Toxemia of pregnancy (HP:0100603)2.42326428
49Broad thumb (HP:0011304)2.41651350
50Atonic seizures (HP:0010819)2.39970844
51Genetic anticipation (HP:0003743)2.37658922
52Abnormality of incisor morphology (HP:0011063)2.36917363
53Hyperventilation (HP:0002883)2.33324596
54Neonatal short-limb short stature (HP:0008921)2.33122557
55Hypoplastic ischia (HP:0003175)2.32942121
56Abnormality of the middle phalanges of the toes (HP:0010183)2.31581272
57Abnormality of the proximal phalanges of the hand (HP:0009834)2.31031630
58Sparse lateral eyebrow (HP:0005338)2.29725380
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28941549
60Bronchomalacia (HP:0002780)2.27532133
61Abnormality of the middle phalanges of the hand (HP:0009833)2.26790580
62Progressive cerebellar ataxia (HP:0002073)2.26612731
63Hemiparesis (HP:0001269)2.26167479
64Renal duplication (HP:0000075)2.25721266
652-3 toe syndactyly (HP:0004691)2.25478645
66Overriding aorta (HP:0002623)2.23303255
67Duplication of thumb phalanx (HP:0009942)2.23178496
68Mesomelia (HP:0003027)2.22305685
69Bifid scrotum (HP:0000048)2.21741901
70Bell-shaped thorax (HP:0001591)2.21313753
71True hermaphroditism (HP:0010459)2.20086461
72Infantile muscular hypotonia (HP:0008947)2.18116904
73* Abnormality of the distal phalanx of the thumb (HP:0009617)2.18107364
74Intestinal fistula (HP:0100819)2.17850451
75Abnormality of the labia majora (HP:0012881)2.17320192
76Absent septum pellucidum (HP:0001331)2.16853812
77Aplasia cutis congenita (HP:0001057)2.16364678
78Abnormality of the antihelix (HP:0009738)2.15419172
79Flat capital femoral epiphysis (HP:0003370)2.15016945
80Rib fusion (HP:0000902)2.14903389
81Febrile seizures (HP:0002373)2.13625151
82Rectovaginal fistula (HP:0000143)2.11782946
83Rectal fistula (HP:0100590)2.11782946
84Oligodactyly (HP:0012165)2.10259432
85Tracheomalacia (HP:0002779)2.09673239
86Action tremor (HP:0002345)2.07367239
87Abnormality of the ischium (HP:0003174)2.06466866
88Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.04583301
89Increased number of teeth (HP:0011069)2.04526594
90Abnormality of the phalanges of the 2nd finger (HP:0009541)2.04075204
91Skull defect (HP:0001362)2.02894637
92Renal dysplasia (HP:0000110)2.02886944
93Preaxial foot polydactyly (HP:0001841)2.02184758
94Missing ribs (HP:0000921)2.01185060
95Concave nail (HP:0001598)1.99516959
96Broad phalanx (HP:0006009)1.98098565
97Large for gestational age (HP:0001520)1.97814096
98Broad finger (HP:0001500)1.96717844
99Broad phalanges of the hand (HP:0009768)1.96625452
100Cutaneous finger syndactyly (HP:0010554)1.96055967
101White forelock (HP:0002211)1.95158585
102Short metatarsal (HP:0010743)1.94700933
103Chorioretinal atrophy (HP:0000533)1.94517166
104Abnormality of the axillary hair (HP:0100134)1.94181558
105Abnormality of secondary sexual hair (HP:0009888)1.94181558
106Abnormality of the septum pellucidum (HP:0007375)1.93644288
107Anal stenosis (HP:0002025)1.93635659
108Broad long bones (HP:0005622)1.93590411
109Hepatoblastoma (HP:0002884)1.93503046
110Mixed hearing impairment (HP:0000410)1.92715969
111Focal seizures (HP:0007359)1.91625191
112Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.91134458
113Wide anterior fontanel (HP:0000260)1.88339631
114Megalencephaly (HP:0001355)1.85717252
115Ectopic anus (HP:0004397)1.84019178
116Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.83709447
117Labial hypoplasia (HP:0000066)1.83379341
118* Supernumerary bones of the axial skeleton (HP:0009144)1.83153835
119Short middle phalanx of finger (HP:0005819)1.81463374
120Renovascular hypertension (HP:0100817)1.81208251
121Partial agenesis of the corpus callosum (HP:0001338)1.80252305
122* Abnormality of the incisor (HP:0000676)1.78550430
123Hypoplasia of the ulna (HP:0003022)1.78512186
124Aplasia/Hypoplasia of the fibula (HP:0006492)1.77986494
125Vaginal fistula (HP:0004320)1.77565766
126Macroorchidism (HP:0000053)1.77023648
127Shawl scrotum (HP:0000049)1.76941800
128Recurrent corneal erosions (HP:0000495)1.76499416
129Cerebellar dysplasia (HP:0007033)1.76497857
130Deep philtrum (HP:0002002)1.76459850
131Protruding ear (HP:0000411)1.75474703
132Hypoventilation (HP:0002791)1.75446362
133Renal hypoplasia (HP:0000089)1.75180409
134Hemiplegia (HP:0002301)1.73814797
135Abnormality of the aortic arch (HP:0012303)1.72708022
136Cutaneous syndactyly (HP:0012725)1.72677774
137Deviation of the hallux (HP:0010051)1.72452171
138* Neoplasm of the oral cavity (HP:0100649)1.72395958
139* Neoplasm of the heart (HP:0100544)1.72088410
140Vaginal atresia (HP:0000148)1.70434278
141Nephronophthisis (HP:0000090)1.70111104
142Urethral obstruction (HP:0000796)1.69846413
143Thickened helices (HP:0000391)1.69432866
144* Supernumerary ribs (HP:0005815)1.69284182
145Premature skin wrinkling (HP:0100678)1.68810168
146Follicular hyperkeratosis (HP:0007502)1.68043830
147Genital tract atresia (HP:0001827)1.66778274
148Synostosis of carpal bones (HP:0005048)1.66688377
149Abnormality of the pubic bones (HP:0003172)1.66512558
150Absence seizures (HP:0002121)1.65928787
151Morphological abnormality of the inner ear (HP:0011390)1.65274947
152Buphthalmos (HP:0000557)1.64673637
153Patellar aplasia (HP:0006443)1.63812876
154Sclerocornea (HP:0000647)1.63537663
155Vertebral hypoplasia (HP:0008417)1.61428811
156Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.61428811
157Abnormal sex determination (HP:0012244)1.61170053
158Sex reversal (HP:0012245)1.61170053
159Sleep apnea (HP:0010535)1.60834329
160Duplicated collecting system (HP:0000081)1.60371774
161Hypoplastic female external genitalia (HP:0012815)1.58908306
162Abnormality of permanent molar morphology (HP:0011071)1.58846145
163Abnormality of the dental root (HP:0006486)1.58846145
164Taurodontia (HP:0000679)1.58846145
165Preaxial hand polydactyly (HP:0001177)1.58496277
166Dialeptic seizures (HP:0011146)1.58459639
167Ectopic kidney (HP:0000086)1.58395697
168Degeneration of the lateral corticospinal tracts (HP:0002314)1.58299195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR25.15899774
2LATS14.19465696
3MAPK154.12493988
4SIK13.19388596
5CASK3.03422460
6DDR22.76499179
7TSSK62.74660321
8PDGFRA2.42264949
9FGFR12.36232460
10CDK122.33897551
11CAMK1G2.27446351
12WEE12.14987265
13MARK12.14845741
14CAMK1D2.12555290
15RIPK12.06565450
16BRD41.82200219
17NTRK21.74724723
18BMX1.56911975
19TGFBR11.53960592
20WNK11.51147819
21ICK1.50184232
22TYRO31.47741242
23PASK1.45903720
24PRKD31.41439481
25STK38L1.38865815
26EPHA31.38131283
27DYRK21.37826961
28PDGFRB1.32501237
29BMPR1B1.27695694
30MAP3K41.24458891
31NTRK31.24384828
32SGK31.24099606
33ACVR1B1.23638399
34CSNK1A1L1.23018877
35CDK31.22963263
36LATS21.18850367
37MTOR1.16568088
38SGK21.15943138
39VRK11.13971786
40FRK1.13749668
41EPHB21.13535047
42ERBB21.09420035
43SGK2230.99200866
44SGK4940.99200866
45CAMKK10.98059672
46STK30.98025293
47TIE10.96138312
48PRKCG0.95612999
49DMPK0.95015559
50PNCK0.92713911
51PAK60.92556290
52CDK60.92074153
53RET0.91333255
54STK380.90349434
55PRKCH0.89229379
56PLK40.87456676
57KSR10.86382256
58WNK40.86262611
59PTK60.86253780
60SIK20.85671891
61TAF10.83756390
62CDC42BPA0.83579021
63EPHB10.83430787
64EPHA40.82627552
65CAMK40.81925549
66MARK20.76635192
67CDK90.76109672
68ADRBK20.74158829
69ALK0.73333298
70MAPKAPK50.72640120
71CSNK1G10.72150528
72MAP3K70.71097620
73PIK3CA0.70545820
74BRSK20.70437347
75MAP3K100.68056122
76LMTK20.67901442
77TRIB30.66728980
78UHMK10.65658217
79FGFR30.65259936
80MAP2K40.64674841
81NLK0.64471006
82FER0.64057784
83PKN10.63122010
84GRK10.63018433
85ROCK10.62858102
86DAPK20.62674020
87PTK20.62265907
88MKNK20.61243495
89MET0.60784674
90PRKD10.58822568
91NUAK10.58057984
92CSNK1D0.57450075
93MKNK10.57284969
94MAPK100.57236700
95CAMK10.56862621
96PAK20.55250650
97ERBB30.55149044
98NTRK10.54992860
99ROCK20.54966463
100CDK40.54124695
101MAPK130.53498801
102STK390.52287496
103GSK3B0.52277312
104CDK10.52147529
105GSK3A0.52010126
106MINK10.51799151
107MAPK80.51792576
108DYRK1B0.51546013
109MAPK140.50467510
110INSRR0.50004858
111MAPK10.49797486
112CHEK20.49643324
113TNIK0.49087779
114CSNK1G20.48881768
115EEF2K0.47987220
116STK110.46171205
117MAP2K20.45591874
118RPS6KA30.45499435
119DYRK30.45220131
120DYRK1A0.44999094
121CDC70.44876564
122CSNK1E0.44590660
123ATM0.44501394
124AKT30.43912873
125CAMKK20.43910607
126SGK10.43776252
127PRKDC0.43689519
128WNK30.43538162
129NEK60.43393125
130PKN20.42718153
131NEK20.42176543
132PLK20.42080230
133PLK30.39974878
134NME10.38418879
135MAPK70.34605072
136CDK50.34561308
137PRKAA10.34246901
138CAMK2A0.34099301
139ZAK0.34093499
140BCR0.32748809
141OXSR10.32246385
142PRKCE0.30379282

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052173.98559906
2Nitrogen metabolism_Homo sapiens_hsa009103.73350875
3* Hedgehog signaling pathway_Homo sapiens_hsa043403.44394338
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.59459391
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14787468
6Wnt signaling pathway_Homo sapiens_hsa043102.02718034
7Hippo signaling pathway_Homo sapiens_hsa043901.89007322
8Taste transduction_Homo sapiens_hsa047421.87169571
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82587631
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.75786506
11ECM-receptor interaction_Homo sapiens_hsa045121.75257284
12Lysine degradation_Homo sapiens_hsa003101.72794112
13TGF-beta signaling pathway_Homo sapiens_hsa043501.65815945
14Axon guidance_Homo sapiens_hsa043601.62687739
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.62028967
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53520061
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53086366
18Adherens junction_Homo sapiens_hsa045201.51212768
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.49910931
20Dorso-ventral axis formation_Homo sapiens_hsa043201.45590067
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44701369
22Melanoma_Homo sapiens_hsa052181.41237048
23Melanogenesis_Homo sapiens_hsa049161.40333951
24Phototransduction_Homo sapiens_hsa047441.40297686
25GABAergic synapse_Homo sapiens_hsa047271.38067774
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36758414
27Prostate cancer_Homo sapiens_hsa052151.33289411
28Nicotine addiction_Homo sapiens_hsa050331.30699221
29Glutamatergic synapse_Homo sapiens_hsa047241.30021313
30Renin secretion_Homo sapiens_hsa049241.29648531
31Colorectal cancer_Homo sapiens_hsa052101.28071682
32Type II diabetes mellitus_Homo sapiens_hsa049301.27451584
33Protein digestion and absorption_Homo sapiens_hsa049741.26739996
34* cAMP signaling pathway_Homo sapiens_hsa040241.23916119
35* Pathways in cancer_Homo sapiens_hsa052001.23172002
36* Proteoglycans in cancer_Homo sapiens_hsa052051.22879457
37MicroRNAs in cancer_Homo sapiens_hsa052061.22142160
38Circadian entrainment_Homo sapiens_hsa047131.22059245
39Butanoate metabolism_Homo sapiens_hsa006501.21464276
40Notch signaling pathway_Homo sapiens_hsa043301.20622884
41Endometrial cancer_Homo sapiens_hsa052131.18515586
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.15964104
43Focal adhesion_Homo sapiens_hsa045101.14678751
44Serotonergic synapse_Homo sapiens_hsa047261.12344983
45Ribosome_Homo sapiens_hsa030101.12147977
46Long-term potentiation_Homo sapiens_hsa047201.06893618
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06869020
48Bile secretion_Homo sapiens_hsa049761.05431843
49Glioma_Homo sapiens_hsa052141.04459226
50Gastric acid secretion_Homo sapiens_hsa049711.04079889
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03749802
52Salivary secretion_Homo sapiens_hsa049701.03739913
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03482278
54Dilated cardiomyopathy_Homo sapiens_hsa054141.03127081
55Morphine addiction_Homo sapiens_hsa050321.02345750
56ErbB signaling pathway_Homo sapiens_hsa040121.01872662
57Insulin secretion_Homo sapiens_hsa049111.01047694
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98938467
59Long-term depression_Homo sapiens_hsa047300.98926672
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98816698
61Gap junction_Homo sapiens_hsa045400.96545162
62Linoleic acid metabolism_Homo sapiens_hsa005910.95989400
63Cocaine addiction_Homo sapiens_hsa050300.94754980
64Small cell lung cancer_Homo sapiens_hsa052220.93764559
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.92747663
66Rap1 signaling pathway_Homo sapiens_hsa040150.92606992
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91733264
68Fatty acid biosynthesis_Homo sapiens_hsa000610.91424168
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91304081
70Estrogen signaling pathway_Homo sapiens_hsa049150.89122682
71Histidine metabolism_Homo sapiens_hsa003400.89092927
72mTOR signaling pathway_Homo sapiens_hsa041500.88771248
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87974600
74Amphetamine addiction_Homo sapiens_hsa050310.86765491
75Cholinergic synapse_Homo sapiens_hsa047250.85209001
76Cardiac muscle contraction_Homo sapiens_hsa042600.84151123
77Renal cell carcinoma_Homo sapiens_hsa052110.83106610
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82303476
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81338641
80Circadian rhythm_Homo sapiens_hsa047100.79298947
81Dopaminergic synapse_Homo sapiens_hsa047280.79200466
82Chronic myeloid leukemia_Homo sapiens_hsa052200.78967299
83MAPK signaling pathway_Homo sapiens_hsa040100.78168053
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76551118
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74911969
86Amoebiasis_Homo sapiens_hsa051460.72951754
87Pancreatic secretion_Homo sapiens_hsa049720.72675112
88Mineral absorption_Homo sapiens_hsa049780.71791069
89AMPK signaling pathway_Homo sapiens_hsa041520.71409539
90Fanconi anemia pathway_Homo sapiens_hsa034600.70915286
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69845378
92Oxytocin signaling pathway_Homo sapiens_hsa049210.69683372
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69454719
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.68747119
95Choline metabolism in cancer_Homo sapiens_hsa052310.68184588
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68145141
97Vitamin digestion and absorption_Homo sapiens_hsa049770.67135129
98GnRH signaling pathway_Homo sapiens_hsa049120.67088713
99Tight junction_Homo sapiens_hsa045300.65636819
100Ras signaling pathway_Homo sapiens_hsa040140.65287242
101Selenocompound metabolism_Homo sapiens_hsa004500.64802538
102Thyroid hormone synthesis_Homo sapiens_hsa049180.64653814
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.63638910
104Non-small cell lung cancer_Homo sapiens_hsa052230.63629539
105Oocyte meiosis_Homo sapiens_hsa041140.62093482
106Olfactory transduction_Homo sapiens_hsa047400.62076409
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61679433
108Ovarian steroidogenesis_Homo sapiens_hsa049130.60386266
109Ether lipid metabolism_Homo sapiens_hsa005650.60144974
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59489212
111Steroid biosynthesis_Homo sapiens_hsa001000.59462082
112Alcoholism_Homo sapiens_hsa050340.59457337
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59450993
114Calcium signaling pathway_Homo sapiens_hsa040200.59331663
115mRNA surveillance pathway_Homo sapiens_hsa030150.58352131
116Insulin resistance_Homo sapiens_hsa049310.56853292
117Basal transcription factors_Homo sapiens_hsa030220.54718140
118Viral myocarditis_Homo sapiens_hsa054160.54504094
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54464307
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54162125
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.53031556
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52858796
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52641959
124ABC transporters_Homo sapiens_hsa020100.52195685
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51979350
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51418509
127Fat digestion and absorption_Homo sapiens_hsa049750.50427798
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49332191
129Homologous recombination_Homo sapiens_hsa034400.47719430
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47605314

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