PTCHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane protein with a patched domain. The encoded protein is similar to Drosophila proteins which act as receptors for the morphogen sonic hedgehog. Deletions in this gene, which is located on the X chromosome, are associated with intellectual disability and autism (PMID: 21091464, PMID: 20844286). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.66206130
2vocalization behavior (GO:0071625)5.36095798
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.19544772
4behavioral response to nicotine (GO:0035095)4.91067030
5synaptic vesicle exocytosis (GO:0016079)4.86712711
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.84734687
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.78744908
8protein localization to synapse (GO:0035418)4.78366396
9presynaptic membrane assembly (GO:0097105)4.64436716
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.63600140
11regulation of glutamate receptor signaling pathway (GO:1900449)4.60296718
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.57983843
13response to histamine (GO:0034776)4.51962359
14glutamate receptor signaling pathway (GO:0007215)4.37319181
15gamma-aminobutyric acid signaling pathway (GO:0007214)4.34189959
16presynaptic membrane organization (GO:0097090)4.24022869
17regulation of synaptic vesicle exocytosis (GO:2000300)4.13442205
18postsynaptic membrane organization (GO:0001941)4.11964476
19neuron recognition (GO:0008038)4.11674796
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.06195799
21neuron-neuron synaptic transmission (GO:0007270)4.03159626
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01329014
23glutamate secretion (GO:0014047)3.94958612
24synaptic transmission, glutamatergic (GO:0035249)3.92916974
25axonal fasciculation (GO:0007413)3.84274942
26cerebellar granule cell differentiation (GO:0021707)3.83087970
27dendritic spine morphogenesis (GO:0060997)3.79394497
28neurotransmitter secretion (GO:0007269)3.78977496
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.78856820
30synaptic vesicle maturation (GO:0016188)3.75878761
31neuronal action potential propagation (GO:0019227)3.73330831
32neurotransmitter-gated ion channel clustering (GO:0072578)3.72200691
33proline transport (GO:0015824)3.70643123
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.68291547
35startle response (GO:0001964)3.67873587
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67658814
37locomotory exploration behavior (GO:0035641)3.67481095
38serotonin metabolic process (GO:0042428)3.65069047
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.58690546
40behavioral response to cocaine (GO:0048148)3.57587180
41regulation of synaptic vesicle transport (GO:1902803)3.54843118
42regulation of postsynaptic membrane potential (GO:0060078)3.54091203
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51615009
44regulation of glutamate secretion (GO:0014048)3.50405043
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45607297
46layer formation in cerebral cortex (GO:0021819)3.44641255
47regulation of cAMP-dependent protein kinase activity (GO:2000479)3.42412172
48exploration behavior (GO:0035640)3.41693432
49synapse assembly (GO:0007416)3.37185013
50positive regulation of synapse assembly (GO:0051965)3.36017063
51transmission of nerve impulse (GO:0019226)3.35649920
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.31185446
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30159091
54regulation of protein kinase A signaling (GO:0010738)3.29036056
55negative regulation of amino acid transport (GO:0051956)3.28217567
56negative regulation of cytosolic calcium ion concentration (GO:0051481)3.27138149
57positive regulation of membrane potential (GO:0045838)3.26366676
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.23176041
59neuronal action potential (GO:0019228)3.22919716
60mating behavior (GO:0007617)3.22348799
61gamma-aminobutyric acid transport (GO:0015812)3.21713027
62long-term synaptic potentiation (GO:0060291)3.18090866
63regulation of vesicle fusion (GO:0031338)3.17423087
64prepulse inhibition (GO:0060134)3.16904608
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15997763
66neurotransmitter transport (GO:0006836)3.15167763
67L-fucose catabolic process (GO:0042355)3.12137863
68fucose catabolic process (GO:0019317)3.12137863
69L-fucose metabolic process (GO:0042354)3.12137863
70membrane depolarization (GO:0051899)3.11203353
71long-term memory (GO:0007616)3.08191282
72behavioral response to ethanol (GO:0048149)3.08086743
73adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.07958951
74cerebellar Purkinje cell differentiation (GO:0021702)3.07646231
75regulation of neurotransmitter secretion (GO:0046928)3.04993922
76regulation of synapse structural plasticity (GO:0051823)3.04449217
77maternal behavior (GO:0042711)3.02822594
78pyrimidine nucleobase catabolic process (GO:0006208)3.01955162
79positive regulation of neurotransmitter secretion (GO:0001956)3.01595394
80regulation of neurotransmitter levels (GO:0001505)3.00949199
81membrane hyperpolarization (GO:0060081)3.00496869
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99575080
83primary amino compound metabolic process (GO:1901160)2.98095479
84response to pheromone (GO:0019236)2.95344820
85dendrite morphogenesis (GO:0048813)2.93647968
86ATP hydrolysis coupled proton transport (GO:0015991)2.91455877
87energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91455877
88intraspecies interaction between organisms (GO:0051703)2.91280733
89social behavior (GO:0035176)2.91280733
90auditory behavior (GO:0031223)2.90519438
91regulation of neuronal synaptic plasticity (GO:0048168)2.88619430
92opioid receptor signaling pathway (GO:0038003)2.87636486
93regulation of voltage-gated calcium channel activity (GO:1901385)2.87403190
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.85840452
95C4-dicarboxylate transport (GO:0015740)2.85378910
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85330374
97regulation of neurotransmitter transport (GO:0051588)2.85173810
98activation of protein kinase A activity (GO:0034199)2.84565610
99positive regulation of synapse maturation (GO:0090129)2.83491173
100regulation of synapse assembly (GO:0051963)2.83105765
101membrane depolarization during action potential (GO:0086010)2.83025848
102synaptic vesicle endocytosis (GO:0048488)2.81757298
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81638823
104response to auditory stimulus (GO:0010996)2.81147091
105regulation of synaptic plasticity (GO:0048167)2.81000653
106detection of light stimulus involved in sensory perception (GO:0050962)2.80594067
107detection of light stimulus involved in visual perception (GO:0050908)2.80594067
108multi-organism reproductive behavior (GO:0044705)2.79861166
109synapse organization (GO:0050808)2.79833964
110positive regulation of neurotransmitter transport (GO:0051590)2.78520738
111learning (GO:0007612)2.78247081
112regulation of dendritic spine development (GO:0060998)2.77702807
113response to amphetamine (GO:0001975)2.77427040
114synaptic transmission (GO:0007268)2.75759455
115reflex (GO:0060004)2.72539484
116DNA double-strand break processing (GO:0000729)2.70947931
117detection of mechanical stimulus involved in sensory perception (GO:0050974)2.70613025
118limb bud formation (GO:0060174)2.70530360
119central nervous system myelination (GO:0022010)2.67581676
120axon ensheathment in central nervous system (GO:0032291)2.67581676
121retinal cone cell development (GO:0046549)2.67398769
122positive regulation of meiosis (GO:0045836)2.64139609
123nucleobase catabolic process (GO:0046113)2.63135717
124somite development (GO:0061053)2.60000899
125indolalkylamine metabolic process (GO:0006586)2.56163542
126regulation of action potential (GO:0098900)2.55647725
127tachykinin receptor signaling pathway (GO:0007217)2.55630201
128epithelial cilium movement (GO:0003351)2.55339313
129mechanosensory behavior (GO:0007638)2.54516844
130regulation of neurotransmitter uptake (GO:0051580)2.54279893
131neuromuscular synaptic transmission (GO:0007274)2.53493005
132retina layer formation (GO:0010842)2.53473693
133glycosphingolipid biosynthetic process (GO:0006688)2.52482810
134nephron epithelium morphogenesis (GO:0072088)2.52350654
135nephron tubule morphogenesis (GO:0072078)2.52350654
136DNA deamination (GO:0045006)2.52303636
137indole-containing compound metabolic process (GO:0042430)2.52303157
138nonmotile primary cilium assembly (GO:0035058)2.52056409
139negative regulation of astrocyte differentiation (GO:0048712)2.51194278
140cilium morphogenesis (GO:0060271)2.47435986
141platelet dense granule organization (GO:0060155)2.47011876
142cochlea development (GO:0090102)2.46722097
143negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46622992
144action potential (GO:0001508)2.45559521
145synaptic transmission, cholinergic (GO:0007271)2.45172579
146regulation of collateral sprouting (GO:0048670)2.43522002
147positive regulation of meiotic cell cycle (GO:0051446)2.43382471
148axoneme assembly (GO:0035082)2.42833656
149kidney morphogenesis (GO:0060993)2.41383706
150positive regulation of oligodendrocyte differentiation (GO:0048714)2.41247693
151water-soluble vitamin biosynthetic process (GO:0042364)2.40559749
152indole-containing compound catabolic process (GO:0042436)2.40297297
153indolalkylamine catabolic process (GO:0046218)2.40297297
154tryptophan catabolic process (GO:0006569)2.40297297
155negative regulation of telomere maintenance (GO:0032205)2.40155158
156photoreceptor cell development (GO:0042461)2.38633692
157regulation of mesoderm development (GO:2000380)2.37166151
158behavioral defense response (GO:0002209)2.35402389
159behavioral fear response (GO:0001662)2.35402389
160protein polyglutamylation (GO:0018095)2.35280877
161renal tubule morphogenesis (GO:0061333)2.34714723
162otic vesicle formation (GO:0030916)2.33982108
163inner ear receptor stereocilium organization (GO:0060122)2.33904749
164protein localization to cilium (GO:0061512)2.33404947
165positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.33058627
166neural tube formation (GO:0001841)2.32972535
167regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.32809233
168regulation of translation, ncRNA-mediated (GO:0045974)2.32024178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96827556
2GBX2_23144817_ChIP-Seq_PC3_Human4.26850101
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94778828
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84092492
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80217007
6TAF15_26573619_Chip-Seq_HEK293_Human2.58330309
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56310630
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48014575
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.44176966
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42934019
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39306748
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39306748
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37274833
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.29644906
15REST_21632747_ChIP-Seq_MESCs_Mouse2.28056201
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26042542
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25716497
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.23712802
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18472155
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14958116
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12375532
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10263808
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.07541847
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00576291
25* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96429989
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93352715
27P300_19829295_ChIP-Seq_ESCs_Human1.93251027
28SMAD4_21799915_ChIP-Seq_A2780_Human1.86759126
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.86450216
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86070663
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85437713
32IGF1R_20145208_ChIP-Seq_DFB_Human1.84024302
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82839630
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.81743660
35DROSHA_22980978_ChIP-Seq_HELA_Human1.79961024
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77335723
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77001066
38AR_21572438_ChIP-Seq_LNCaP_Human1.72732127
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68189487
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.67662245
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67440448
42RNF2_27304074_Chip-Seq_NSC_Mouse1.64897358
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.63911521
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.63764041
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63540778
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.63063388
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63014738
48FUS_26573619_Chip-Seq_HEK293_Human1.61848053
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.58419978
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57292552
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54485348
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51026545
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.50738354
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50534604
55AR_25329375_ChIP-Seq_VCAP_Human1.50196100
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47601579
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47389309
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45820266
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45298716
60VDR_22108803_ChIP-Seq_LS180_Human1.45201982
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43243696
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41314115
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40150713
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39207569
65ER_23166858_ChIP-Seq_MCF-7_Human1.34722808
66* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33984620
67CBP_20019798_ChIP-Seq_JUKART_Human1.33200320
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33200320
69TP53_18474530_ChIP-ChIP_U2OS_Human1.32456261
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.31449367
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30304134
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29234900
73STAT3_23295773_ChIP-Seq_U87_Human1.28004258
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27389569
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.27202121
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26963701
77TCF4_22108803_ChIP-Seq_LS180_Human1.25922333
78ZNF274_21170338_ChIP-Seq_K562_Hela1.25835154
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24170154
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.24020909
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23451357
82* RUNX2_22187159_ChIP-Seq_PCA_Human1.22141990
83* SMAD4_21741376_ChIP-Seq_EPCs_Human1.21601378
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21314994
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21049780
86BCAT_22108803_ChIP-Seq_LS180_Human1.20966461
87AHR_22903824_ChIP-Seq_MCF-7_Human1.19685068
88TCF4_23295773_ChIP-Seq_U87_Human1.19564127
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19208310
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18741120
91NANOG_19829295_ChIP-Seq_ESCs_Human1.18573227
92SOX2_19829295_ChIP-Seq_ESCs_Human1.18573227
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17942452
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17800781
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17208705
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16891027
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.14900537
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.14602621
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12062623
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.11987554
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.11491822
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.11107168
103EWS_26573619_Chip-Seq_HEK293_Human1.10606581
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09362789
105TP53_22573176_ChIP-Seq_HFKS_Human1.08386190
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08102018
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06193564
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.05921864
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05610746
110JUN_21703547_ChIP-Seq_K562_Human1.05090739
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.04223204
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03142214
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03142214
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02795471
115* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01881408
116KDM2B_26808549_Chip-Seq_REH_Human1.01841322
117NOTCH1_21737748_ChIP-Seq_TLL_Human1.01774049
118AR_19668381_ChIP-Seq_PC3_Human1.01507808
119MYC_18940864_ChIP-ChIP_HL60_Human1.01487620
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.00597624
121P53_22387025_ChIP-Seq_ESCs_Mouse1.00297777
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.98857895
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98192677
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.97974928
125RING1B_27294783_Chip-Seq_ESCs_Mouse0.94269440
126SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92596486
127CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91658485
128* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91179117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.99771676
2MP0004859_abnormal_synaptic_plasticity4.72437543
3MP0003635_abnormal_synaptic_transmissio3.92319389
4MP0004270_analgesia3.79334711
5MP0009046_muscle_twitch3.56095831
6MP0009745_abnormal_behavioral_response3.54762089
7MP0002064_seizures3.26027144
8MP0002063_abnormal_learning/memory/cond3.15781105
9MP0001968_abnormal_touch/_nociception3.03338237
10MP0002572_abnormal_emotion/affect_behav2.95353795
11MP0002734_abnormal_mechanical_nocicepti2.83366467
12MP0001440_abnormal_grooming_behavior2.64397402
13MP0006276_abnormal_autonomic_nervous2.61525528
14MP0001486_abnormal_startle_reflex2.57380028
15MP0002272_abnormal_nervous_system2.55154580
16MP0002102_abnormal_ear_morphology2.53880430
17MP0008877_abnormal_DNA_methylation2.50643193
18MP0002736_abnormal_nociception_after2.39957338
19MP0001188_hyperpigmentation2.35120947
20MP0002067_abnormal_sensory_capabilities2.27554535
21MP0005423_abnormal_somatic_nervous2.26529086
22MP0001501_abnormal_sleep_pattern2.23905989
23MP0003136_yellow_coat_color2.23431847
24MP0000569_abnormal_digit_pigmentation2.15367041
25MP0002733_abnormal_thermal_nociception2.14753405
26MP0002184_abnormal_innervation2.13465967
27MP0000778_abnormal_nervous_system2.13451976
28MP0002735_abnormal_chemical_nociception2.10780361
29MP0001984_abnormal_olfaction2.04406174
30MP0001970_abnormal_pain_threshold2.01792100
31MP0001529_abnormal_vocalization1.99917688
32MP0005386_behavior/neurological_phenoty1.98748029
33MP0004924_abnormal_behavior1.98748029
34MP0002822_catalepsy1.92371820
35MP0002557_abnormal_social/conspecific_i1.84775007
36MP0004133_heterotaxia1.78310771
37MP0006292_abnormal_olfactory_placode1.77732954
38MP0004142_abnormal_muscle_tone1.76196972
39MP0003122_maternal_imprinting1.71727314
40MP0003195_calcinosis1.67574696
41MP0006072_abnormal_retinal_apoptosis1.65570760
42MP0001905_abnormal_dopamine_level1.65005858
43MP0005253_abnormal_eye_physiology1.63679074
44MP0002653_abnormal_ependyma_morphology1.61227400
45MP0008569_lethality_at_weaning1.58042856
46MP0004510_myositis1.57900116
47MP0002938_white_spotting1.47913403
48MP0003890_abnormal_embryonic-extraembry1.46473887
49MP0004742_abnormal_vestibular_system1.43332041
50MP0000372_irregular_coat_pigmentation1.42630980
51MP0001502_abnormal_circadian_rhythm1.41431980
52MP0003879_abnormal_hair_cell1.41086759
53MP0004811_abnormal_neuron_physiology1.40367954
54MP0002066_abnormal_motor_capabilities/c1.39468036
55MP0003283_abnormal_digestive_organ1.37572321
56MP0002882_abnormal_neuron_morphology1.35550601
57MP0000955_abnormal_spinal_cord1.30524849
58MP0002876_abnormal_thyroid_physiology1.25439542
59MP0001986_abnormal_taste_sensitivity1.23644283
60MP0005645_abnormal_hypothalamus_physiol1.23375458
61MP0003329_amyloid_beta_deposits1.22659307
62MP0003787_abnormal_imprinting1.21802626
63MP0005171_absent_coat_pigmentation1.19137076
64MP0003119_abnormal_digestive_system1.16080585
65MP0004147_increased_porphyrin_level1.15308439
66MP0005646_abnormal_pituitary_gland1.12883508
67MP0003937_abnormal_limbs/digits/tail_de1.11275761
68MP0001348_abnormal_lacrimal_gland1.08994025
69MP0000427_abnormal_hair_cycle1.07836217
70MP0000049_abnormal_middle_ear1.07584443
71MP0003633_abnormal_nervous_system1.07154174
72MP0003011_delayed_dark_adaptation1.06600634
73MP0002234_abnormal_pharynx_morphology1.06285300
74MP0004885_abnormal_endolymph1.03035288
75MP0002152_abnormal_brain_morphology1.02573252
76MP0008872_abnormal_physiological_respon1.02510323
77MP0003303_peritoneal_inflammation1.00986771
78MP0010386_abnormal_urinary_bladder1.00334775
79MP0004145_abnormal_muscle_electrophysio1.00092308
80MP0002638_abnormal_pupillary_reflex0.98406153
81MP0000604_amyloidosis0.98117941
82MP0003631_nervous_system_phenotype0.97529458
83MP0004043_abnormal_pH_regulation0.97459290
84MP0005195_abnormal_posterior_eye0.96558677
85MP0005174_abnormal_tail_pigmentation0.96425373
86MP0002163_abnormal_gland_morphology0.95284198
87MP0009780_abnormal_chondrocyte_physiolo0.93767005
88MP0004858_abnormal_nervous_system0.93520958
89MP0005409_darkened_coat_color0.93501400
90MP0003646_muscle_fatigue0.93389495
91MP0000015_abnormal_ear_pigmentation0.93275047
92MP0002751_abnormal_autonomic_nervous0.92232281
93MP0008874_decreased_physiological_sensi0.91863237
94MP0003938_abnormal_ear_development0.89856017
95MP0002909_abnormal_adrenal_gland0.89403953
96MP0001963_abnormal_hearing_physiology0.88618333
97MP0002229_neurodegeneration0.88066777
98MP0003634_abnormal_glial_cell0.86680402
99MP0002095_abnormal_skin_pigmentation0.83124916
100MP0002069_abnormal_eating/drinking_beha0.81254857
101MP0005310_abnormal_salivary_gland0.80836775
102MP0001324_abnormal_eye_pigmentation0.80627561
103MP0003690_abnormal_glial_cell0.80019576
104MP0004085_abnormal_heartbeat0.79909796
105MP0002752_abnormal_somatic_nervous0.78874850
106MP0000647_abnormal_sebaceous_gland0.78273474
107MP0005084_abnormal_gallbladder_morpholo0.78014496
108MP0002928_abnormal_bile_duct0.77694722
109MP0000920_abnormal_myelination0.77469592
110MP0002138_abnormal_hepatobiliary_system0.77295615
111MP0005535_abnormal_body_temperature0.77131333
112MP0000631_abnormal_neuroendocrine_gland0.77095861
113MP0001293_anophthalmia0.77029759
114MP0005379_endocrine/exocrine_gland_phen0.76879248
115MP0000566_synostosis0.76660528
116MP0000383_abnormal_hair_follicle0.75571728
117MP0003632_abnormal_nervous_system0.74400059
118MP0003137_abnormal_impulse_conducting0.74397828
119MP0009379_abnormal_foot_pigmentation0.73598926
120MP0002837_dystrophic_cardiac_calcinosis0.73373016
121MP0002160_abnormal_reproductive_system0.73147212
122MP0001485_abnormal_pinna_reflex0.72437922
123MP0005394_taste/olfaction_phenotype0.72354110
124MP0005499_abnormal_olfactory_system0.72354110
125MP0001299_abnormal_eye_distance/0.71143081
126MP0005551_abnormal_eye_electrophysiolog0.70402377
127MP0002090_abnormal_vision0.66976334
128MP0001943_abnormal_respiration0.65849195
129MP0000751_myopathy0.63113113
130MP0003172_abnormal_lysosome_physiology0.57884498
131MP0000026_abnormal_inner_ear0.57594814
132MP0003183_abnormal_peptide_metabolism0.57197903
133MP0002277_abnormal_respiratory_mucosa0.55420376
134MP0004215_abnormal_myocardial_fiber0.54185949
135MP0001346_abnormal_lacrimal_gland0.51473826
136MP0003121_genomic_imprinting0.50770882
137MP0010770_preweaning_lethality0.49024367

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.27988961
2Atonic seizures (HP:0010819)5.87601255
3Focal seizures (HP:0007359)5.86846303
4Epileptic encephalopathy (HP:0200134)5.16705251
5Febrile seizures (HP:0002373)4.97118434
6Myokymia (HP:0002411)4.83497684
7Absence seizures (HP:0002121)4.77678625
8Visual hallucinations (HP:0002367)4.57802521
9Dialeptic seizures (HP:0011146)4.51274869
10Generalized tonic-clonic seizures (HP:0002069)4.37126723
11Progressive cerebellar ataxia (HP:0002073)4.35824443
12Pancreatic cysts (HP:0001737)3.97297875
13Limb dystonia (HP:0002451)3.89630033
14True hermaphroditism (HP:0010459)3.77717686
15Broad-based gait (HP:0002136)3.71845345
16Abnormality of midbrain morphology (HP:0002418)3.70213220
17Molar tooth sign on MRI (HP:0002419)3.70213220
18Pancreatic fibrosis (HP:0100732)3.70209934
19Hypothermia (HP:0002045)3.63659322
20Hyperventilation (HP:0002883)3.60364361
21Truncal ataxia (HP:0002078)3.45007076
22Gaze-evoked nystagmus (HP:0000640)3.39815658
23Excessive salivation (HP:0003781)3.29601202
24Drooling (HP:0002307)3.29601202
25Nephronophthisis (HP:0000090)3.28927471
26Mutism (HP:0002300)3.25652852
27Congenital stationary night blindness (HP:0007642)3.10591002
28Polyphagia (HP:0002591)2.97703407
29Supranuclear gaze palsy (HP:0000605)2.95013187
30Amblyopia (HP:0000646)2.89111361
31Abnormal hair whorl (HP:0010721)2.86872405
32Abnormality of the renal medulla (HP:0100957)2.84570112
33Dysdiadochokinesis (HP:0002075)2.78660795
34Type II lissencephaly (HP:0007260)2.76910467
35Fetal akinesia sequence (HP:0001989)2.74927598
36Abnormal eating behavior (HP:0100738)2.71578854
37Progressive inability to walk (HP:0002505)2.70134827
38Abnormality of the corticospinal tract (HP:0002492)2.69641800
39Inappropriate behavior (HP:0000719)2.65352489
40Cystic liver disease (HP:0006706)2.64129531
41Abnormality of the renal cortex (HP:0011035)2.58004996
42Sensory axonal neuropathy (HP:0003390)2.55805779
43Action tremor (HP:0002345)2.54620781
44Abolished electroretinogram (ERG) (HP:0000550)2.54180606
45Gait imbalance (HP:0002141)2.52086428
46Protruding tongue (HP:0010808)2.50978675
47Impaired smooth pursuit (HP:0007772)2.50953199
48Poor eye contact (HP:0000817)2.48610031
49Agitation (HP:0000713)2.48041980
50Abnormality of salivation (HP:0100755)2.47441815
51Akinesia (HP:0002304)2.47121859
52Cerebral inclusion bodies (HP:0100314)2.45271261
53Epileptiform EEG discharges (HP:0011182)2.44692309
54Impaired vibration sensation in the lower limbs (HP:0002166)2.43387561
55Dysmetria (HP:0001310)2.42985083
56Neurofibrillary tangles (HP:0002185)2.42207168
57Abnormality of the labia minora (HP:0012880)2.41151032
58Stereotypic behavior (HP:0000733)2.40404517
59Dysmetric saccades (HP:0000641)2.39117415
60Hyperthyroidism (HP:0000836)2.38876086
61Hemiparesis (HP:0001269)2.38237802
62Scanning speech (HP:0002168)2.35691985
63Urinary bladder sphincter dysfunction (HP:0002839)2.33273445
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30021097
65Status epilepticus (HP:0002133)2.29301040
66Failure to thrive in infancy (HP:0001531)2.29253221
67Lissencephaly (HP:0001339)2.27274052
68Diplopia (HP:0000651)2.26961878
69Abnormality of binocular vision (HP:0011514)2.26961878
70Decreased central vision (HP:0007663)2.25316945
71Keratoconus (HP:0000563)2.24306445
72Increased corneal curvature (HP:0100692)2.24306445
73Insidious onset (HP:0003587)2.23177111
74Termporal pattern (HP:0011008)2.23177111
75Tubular atrophy (HP:0000092)2.22499222
76Genetic anticipation (HP:0003743)2.22072993
77Sclerocornea (HP:0000647)2.21482423
78Dynein arm defect of respiratory motile cilia (HP:0012255)2.20602306
79Absent/shortened dynein arms (HP:0200106)2.20602306
80Psychosis (HP:0000709)2.18204561
81EEG with generalized epileptiform discharges (HP:0011198)2.17412246
82Abnormality of ocular smooth pursuit (HP:0000617)2.16645003
83Optic nerve hypoplasia (HP:0000609)2.16265610
84Pendular nystagmus (HP:0012043)2.15521933
85Anxiety (HP:0000739)2.15465086
86Generalized myoclonic seizures (HP:0002123)2.15433438
87Papilledema (HP:0001085)2.15334730
88Impaired social interactions (HP:0000735)2.14385333
89Abnormal social behavior (HP:0012433)2.14385333
90Chronic hepatic failure (HP:0100626)2.13826589
91Attenuation of retinal blood vessels (HP:0007843)2.13320639
92Abnormal ciliary motility (HP:0012262)2.12407077
93Degeneration of the lateral corticospinal tracts (HP:0002314)2.12339712
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12339712
95Exotropia (HP:0000577)2.12105923
96Genital tract atresia (HP:0001827)2.11237794
97Inability to walk (HP:0002540)2.10942185
98Intestinal atresia (HP:0011100)2.09402727
99Polydipsia (HP:0001959)2.08828615
100Abnormal drinking behavior (HP:0030082)2.08828615
101Blue irides (HP:0000635)2.07555221
102Vaginal atresia (HP:0000148)2.07552609
103Depression (HP:0000716)2.06356082
104Concave nail (HP:0001598)2.04623110
105Hypoventilation (HP:0002791)2.04315235
106Anencephaly (HP:0002323)2.04037050
107Specific learning disability (HP:0001328)2.03414740
108Torticollis (HP:0000473)2.03377862
109Medial flaring of the eyebrow (HP:0010747)2.01600373
110Pheochromocytoma (HP:0002666)2.01532086
111Aplasia/Hypoplasia of the tibia (HP:0005772)2.01268054
112Congenital, generalized hypertrichosis (HP:0004540)1.99914135
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99822831
114Abnormality of alanine metabolism (HP:0010916)1.99822831
115Hyperalaninemia (HP:0003348)1.99822831
116Fair hair (HP:0002286)1.98982470
117Neuroendocrine neoplasm (HP:0100634)1.98961493
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.98296806
119Postural tremor (HP:0002174)1.98175641
120Amyotrophic lateral sclerosis (HP:0007354)1.97429286
121Congenital primary aphakia (HP:0007707)1.97340919
122Furrowed tongue (HP:0000221)1.96957654
123Absent speech (HP:0001344)1.96386345
124Hypsarrhythmia (HP:0002521)1.95511302
125Urinary urgency (HP:0000012)1.95329993
126Generalized hypopigmentation of hair (HP:0011358)1.94919700
127Retrobulbar optic neuritis (HP:0100654)1.92286816
128Optic neuritis (HP:0100653)1.92286816
129Spastic gait (HP:0002064)1.90985101
130Heterochromia iridis (HP:0001100)1.90899203
131Nephrogenic diabetes insipidus (HP:0009806)1.89457186
132Renal cortical cysts (HP:0000803)1.88720314
133Postural instability (HP:0002172)1.86710083
134Preaxial hand polydactyly (HP:0001177)1.85601554
135Disinhibition (HP:0000734)1.84292409
136Short hallux (HP:0010109)1.84140388
137Ankle clonus (HP:0011448)1.84101761
138Colon cancer (HP:0003003)1.83566671
139Incomplete penetrance (HP:0003829)1.83193582
140Esotropia (HP:0000565)1.82998049
141Lower limb asymmetry (HP:0100559)1.82474462
142Lower limb muscle weakness (HP:0007340)1.82268477
143Chorioretinal atrophy (HP:0000533)1.82004035
144Progressive macrocephaly (HP:0004481)1.81144465
145Polyuria (HP:0000103)1.81008965
146Postaxial foot polydactyly (HP:0001830)1.80423477
147Acute necrotizing encephalopathy (HP:0006965)1.80371311
148Congenital hepatic fibrosis (HP:0002612)1.79020108
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78882116
150Aplasia/Hypoplasia of the hallux (HP:0008362)1.78838936
151Cerebellar dysplasia (HP:0007033)1.77275423
152Abnormal biliary tract physiology (HP:0012439)1.76591245
153Bile duct proliferation (HP:0001408)1.76591245
154Pachygyria (HP:0001302)1.76231537
155Postaxial hand polydactyly (HP:0001162)1.75701354
156Preaxial foot polydactyly (HP:0001841)1.73989768
157Male pseudohermaphroditism (HP:0000037)1.73079174
158Large for gestational age (HP:0001520)1.68612415
159Abnormality of macular pigmentation (HP:0008002)1.68524227
160Stenosis of the external auditory canal (HP:0000402)1.68042882
161Stomach cancer (HP:0012126)1.67157890
162Abnormal respiratory epithelium morphology (HP:0012253)1.66379080
163Abnormal respiratory motile cilium morphology (HP:0005938)1.66379080
164Oligodactyly (hands) (HP:0001180)1.65991304
165Ectopic kidney (HP:0000086)1.64874884
166Septo-optic dysplasia (HP:0100842)1.64463159
167Gastrointestinal atresia (HP:0002589)1.61410018
168Abnormal rod and cone electroretinograms (HP:0008323)1.61109618

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.35602845
2CASK4.26630104
3MARK13.23340322
4MAP3K92.70910195
5MAP2K72.69185850
6MAP3K42.64128671
7MAP3K122.50083748
8RIPK42.48650478
9TNIK2.44158894
10PRPF4B2.41630352
11MINK12.40875752
12NUAK12.34815056
13PINK12.20129660
14DAPK22.13495686
15GRK12.12211279
16BMPR22.09152898
17EPHA42.07067064
18CDK191.95876639
19CAMKK21.94152715
20MAPK131.93758378
21TRIM281.93241088
22PLK21.89664899
23MAP4K21.89274349
24ACVR1B1.86053417
25NTRK21.77871220
26MAP2K41.72598415
27ZAK1.68271787
28SIK31.55946737
29GRK51.54663291
30AKT31.52655223
31SIK21.52015318
32INSRR1.50360955
33DAPK11.44932410
34PAK61.42402368
35KSR11.39830057
36MKNK21.36286116
37ARAF1.31162565
38FES1.30698447
39CDK51.27956931
40BCR1.25212136
41OXSR11.24990494
42CAMK2A1.23494103
43ERBB31.23262044
44PNCK1.20068175
45CAMKK11.18065118
46WNK41.17471194
47TAOK31.11311230
48TLK11.10659395
49SGK21.08711459
50PRKCG1.07458225
51WEE11.06106955
52BMPR1B1.04837643
53TSSK61.01695457
54FGR1.00681316
55KSR21.00451976
56SGK4940.96879799
57SGK2230.96879799
58VRK10.95348626
59PLK30.93641537
60CSNK1G20.93204982
61NTRK10.91720165
62CAMK2B0.90656005
63PTK2B0.89896900
64CSNK1G10.89286821
65TGFBR10.87652034
66MAPK150.86998369
67TAF10.85249504
68PAK30.84989390
69PKN10.84302917
70GRK70.83039777
71ADRBK20.80888367
72CDK140.80741502
73CDK180.77814111
74PLK40.77153364
75CSNK1A1L0.75748309
76UHMK10.75538557
77MAP3K130.75135160
78PRKCE0.74038526
79DYRK1A0.73562963
80TXK0.72905414
81PHKG20.72674316
82PHKG10.72674316
83STK240.72012085
84ADRBK10.71858846
85CDK150.70651841
86MKNK10.69452814
87STK110.69210582
88EPHA30.66283226
89SGK10.62571970
90RPS6KA20.61711302
91CAMK2D0.60987486
92STK38L0.59865012
93RET0.59646577
94MAPKAPK50.59106075
95CSNK1G30.58575059
96SGK30.56956345
97CDK11A0.56701431
98STK30.55727853
99MUSK0.55230919
100IRAK10.55090387
101NLK0.53881666
102FRK0.53318757
103CSNK1A10.52386413
104BRAF0.52178882
105DAPK30.50677543
106FGFR20.50425577
107CAMK2G0.48250245
108DYRK20.47907216
109PIK3CA0.45484908
110TIE10.45300841
111PRKCH0.45246766
112PRKCZ0.44979245
113CCNB10.44328389
114CSNK1D0.43590548
115PRKG10.43558839
116MAP2K60.42632399
117FYN0.41880377
118ERBB20.41832029
119YES10.41548250
120MAP3K20.41431137
121STK160.41189748
122CDC42BPA0.40889224
123WNK30.40770320
124PRKCB0.40643838
125MST40.40634757
126MAP3K140.38492395
127RPS6KA30.38368727
128STK390.37697077
129WNK10.37450884
130SCYL20.36735799
131CDK30.36702519
132CDC70.36657540
133CAMK40.36619630
134MAP2K10.36168843
135PRKACA0.35922099
136PRKCA0.34905611
137BRSK20.33795309
138MAPK120.33608672
139CAMK10.33511227
140LATS20.33481356
141PLK10.33405605
142BCKDK0.33260749
143NME10.30924953
144MARK20.30871631

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.02704219
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19310076
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78455618
4Morphine addiction_Homo sapiens_hsa050322.62649305
5Nitrogen metabolism_Homo sapiens_hsa009102.52118837
6GABAergic synapse_Homo sapiens_hsa047272.50567176
7Olfactory transduction_Homo sapiens_hsa047402.45436250
8Collecting duct acid secretion_Homo sapiens_hsa049662.43135940
9Circadian entrainment_Homo sapiens_hsa047132.41537300
10Long-term potentiation_Homo sapiens_hsa047202.39528818
11Glutamatergic synapse_Homo sapiens_hsa047242.37422822
12Amphetamine addiction_Homo sapiens_hsa050312.24577501
13Serotonergic synapse_Homo sapiens_hsa047262.11785753
14Dopaminergic synapse_Homo sapiens_hsa047282.09637936
15Taste transduction_Homo sapiens_hsa047422.00201445
16Butanoate metabolism_Homo sapiens_hsa006501.86041345
17Renin secretion_Homo sapiens_hsa049241.83819793
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83681064
19Long-term depression_Homo sapiens_hsa047301.83617780
20Cocaine addiction_Homo sapiens_hsa050301.77874992
21Cholinergic synapse_Homo sapiens_hsa047251.76988341
22Salivary secretion_Homo sapiens_hsa049701.70297107
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70002802
24Linoleic acid metabolism_Homo sapiens_hsa005911.69104218
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67608046
26Protein export_Homo sapiens_hsa030601.56324155
27Oxytocin signaling pathway_Homo sapiens_hsa049211.54033140
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.53521575
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53018661
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52619781
31Selenocompound metabolism_Homo sapiens_hsa004501.50312305
32Oxidative phosphorylation_Homo sapiens_hsa001901.47171104
33Basal transcription factors_Homo sapiens_hsa030221.45039182
34Gastric acid secretion_Homo sapiens_hsa049711.44077399
35Vibrio cholerae infection_Homo sapiens_hsa051101.43766284
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43150597
37Ether lipid metabolism_Homo sapiens_hsa005651.41078966
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39640405
39Insulin secretion_Homo sapiens_hsa049111.37157705
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36651844
41Calcium signaling pathway_Homo sapiens_hsa040201.33125415
42GnRH signaling pathway_Homo sapiens_hsa049121.32306928
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29515852
44Fanconi anemia pathway_Homo sapiens_hsa034601.25042618
45Homologous recombination_Homo sapiens_hsa034401.23775598
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22210031
47Tryptophan metabolism_Homo sapiens_hsa003801.20468774
48Type II diabetes mellitus_Homo sapiens_hsa049301.19744276
49Alzheimers disease_Homo sapiens_hsa050101.18079956
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16650135
51Cardiac muscle contraction_Homo sapiens_hsa042601.15952048
52Propanoate metabolism_Homo sapiens_hsa006401.15266963
53Axon guidance_Homo sapiens_hsa043601.15094994
54Phototransduction_Homo sapiens_hsa047441.12448622
55Gap junction_Homo sapiens_hsa045401.11096540
56RNA degradation_Homo sapiens_hsa030181.10124838
57Estrogen signaling pathway_Homo sapiens_hsa049151.09819444
58Rheumatoid arthritis_Homo sapiens_hsa053231.08668530
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.06199993
60ErbB signaling pathway_Homo sapiens_hsa040121.04779924
61cAMP signaling pathway_Homo sapiens_hsa040241.04706395
62Parkinsons disease_Homo sapiens_hsa050121.01093156
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00898428
64Caffeine metabolism_Homo sapiens_hsa002321.00025017
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99985856
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98691069
67RNA polymerase_Homo sapiens_hsa030200.98602016
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95632526
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93442503
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91646635
71Phagosome_Homo sapiens_hsa041450.91234732
72Glioma_Homo sapiens_hsa052140.87438466
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87437614
74Peroxisome_Homo sapiens_hsa041460.86294797
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84983849
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83104342
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80233021
78Chemical carcinogenesis_Homo sapiens_hsa052040.79018678
79Steroid biosynthesis_Homo sapiens_hsa001000.78765954
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.77335641
81MAPK signaling pathway_Homo sapiens_hsa040100.75859773
82Melanogenesis_Homo sapiens_hsa049160.73379668
83Retinol metabolism_Homo sapiens_hsa008300.71960421
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71930996
85African trypanosomiasis_Homo sapiens_hsa051430.68903976
86Dilated cardiomyopathy_Homo sapiens_hsa054140.68894497
87beta-Alanine metabolism_Homo sapiens_hsa004100.68378947
88ABC transporters_Homo sapiens_hsa020100.68176932
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.67844553
90Huntingtons disease_Homo sapiens_hsa050160.67699413
91Dorso-ventral axis formation_Homo sapiens_hsa043200.67657681
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65401777
93Basal cell carcinoma_Homo sapiens_hsa052170.64449345
94Ras signaling pathway_Homo sapiens_hsa040140.63553037
95Alcoholism_Homo sapiens_hsa050340.62106280
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.61610038
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60547508
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60144355
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60105979
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.59620837
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.59603179
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59222711
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58424382
104Histidine metabolism_Homo sapiens_hsa003400.58056368
105Chemokine signaling pathway_Homo sapiens_hsa040620.58053739
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57548446
107Hippo signaling pathway_Homo sapiens_hsa043900.56841402
108Regulation of autophagy_Homo sapiens_hsa041400.56692205
109Hedgehog signaling pathway_Homo sapiens_hsa043400.56248050
110Thyroid hormone synthesis_Homo sapiens_hsa049180.54545016
111Glycerolipid metabolism_Homo sapiens_hsa005610.53550906
112Purine metabolism_Homo sapiens_hsa002300.51285061
113One carbon pool by folate_Homo sapiens_hsa006700.50282395
114Arachidonic acid metabolism_Homo sapiens_hsa005900.49674485
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49035689
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48055573
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47727128
118Type I diabetes mellitus_Homo sapiens_hsa049400.47301748
119Renal cell carcinoma_Homo sapiens_hsa052110.46820033
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46506397
121Non-homologous end-joining_Homo sapiens_hsa034500.46327302
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.46264702
123Choline metabolism in cancer_Homo sapiens_hsa052310.46183612
124Pancreatic secretion_Homo sapiens_hsa049720.45350889
125Ovarian steroidogenesis_Homo sapiens_hsa049130.44823288
126Oocyte meiosis_Homo sapiens_hsa041140.44438043
127TGF-beta signaling pathway_Homo sapiens_hsa043500.43445803
128VEGF signaling pathway_Homo sapiens_hsa043700.43171960
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42864806
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42771184
131Mineral absorption_Homo sapiens_hsa049780.41296374
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41053634
133Osteoclast differentiation_Homo sapiens_hsa043800.40800554
134Rap1 signaling pathway_Homo sapiens_hsa040150.40521131
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40130080
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39628477
137Autoimmune thyroid disease_Homo sapiens_hsa053200.39366810
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39193671
139Inositol phosphate metabolism_Homo sapiens_hsa005620.39049890
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38461911
141Prion diseases_Homo sapiens_hsa050200.38251574
142Melanoma_Homo sapiens_hsa052180.37712363
143Tuberculosis_Homo sapiens_hsa051520.37680596
144Prolactin signaling pathway_Homo sapiens_hsa049170.34747000
145Endometrial cancer_Homo sapiens_hsa052130.33284941
146Circadian rhythm_Homo sapiens_hsa047100.32664045
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32492115
148Phenylalanine metabolism_Homo sapiens_hsa003600.32476139
149Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30923295
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30662157
151mTOR signaling pathway_Homo sapiens_hsa041500.30543948

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