PTCHD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)6.20521016
2presynaptic membrane organization (GO:0097090)5.52036358
3neuron cell-cell adhesion (GO:0007158)5.44290647
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.42435633
5regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.31374034
6vocalization behavior (GO:0071625)5.25416825
7synaptic transmission, glutamatergic (GO:0035249)5.11233279
8negative regulation of synaptic transmission, GABAergic (GO:0032229)5.10525754
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.08188985
10gamma-aminobutyric acid transport (GO:0015812)5.05744267
11postsynaptic membrane organization (GO:0001941)5.02834536
12glutamate receptor signaling pathway (GO:0007215)5.00775465
13neurotransmitter-gated ion channel clustering (GO:0072578)4.96597730
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.95231706
15startle response (GO:0001964)4.83349865
16regulation of glutamate receptor signaling pathway (GO:1900449)4.79560402
17synaptic vesicle exocytosis (GO:0016079)4.77909824
18neuron-neuron synaptic transmission (GO:0007270)4.71546322
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.59415200
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.55779259
21regulation of short-term neuronal synaptic plasticity (GO:0048172)4.53219514
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.52379092
23protein localization to synapse (GO:0035418)4.49461974
24response to histamine (GO:0034776)4.38866255
25glutamate secretion (GO:0014047)4.32943374
26platelet dense granule organization (GO:0060155)4.31799721
27cerebellar granule cell differentiation (GO:0021707)4.29473085
28neuronal action potential propagation (GO:0019227)4.11301918
29positive regulation of synapse assembly (GO:0051965)3.97838643
30behavioral response to nicotine (GO:0035095)3.89414369
31positive regulation of synapse maturation (GO:0090129)3.88052263
32regulation of synaptic transmission, glutamatergic (GO:0051966)3.87161857
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.85600691
34neuron recognition (GO:0008038)3.81635768
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.81059691
36serotonin receptor signaling pathway (GO:0007210)3.72480087
37axonal fasciculation (GO:0007413)3.71664260
38positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.71227775
39neurotransmitter secretion (GO:0007269)3.69428747
40mechanosensory behavior (GO:0007638)3.67580499
41auditory behavior (GO:0031223)3.67386890
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66624149
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.62333739
44regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.62183367
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56036388
46transmission of nerve impulse (GO:0019226)3.55000395
47regulation of synaptic vesicle exocytosis (GO:2000300)3.53279138
48proline transport (GO:0015824)3.50322754
49regulation of respiratory system process (GO:0044065)3.43719615
50cochlea development (GO:0090102)3.41086721
51regulation of postsynaptic membrane potential (GO:0060078)3.40736492
52regulation of synapse maturation (GO:0090128)3.39443009
53cerebellar Purkinje cell differentiation (GO:0021702)3.38595613
54long-term synaptic potentiation (GO:0060291)3.36408267
55C4-dicarboxylate transport (GO:0015740)3.33290284
56fucose catabolic process (GO:0019317)3.30825868
57L-fucose metabolic process (GO:0042354)3.30825868
58L-fucose catabolic process (GO:0042355)3.30825868
59regulation of synapse assembly (GO:0051963)3.30460808
60oligosaccharide biosynthetic process (GO:0009312)3.27274689
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.26687850
62locomotory exploration behavior (GO:0035641)3.23696369
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23054908
64long-term memory (GO:0007616)3.19287967
65response to auditory stimulus (GO:0010996)3.19253587
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17861428
67regulation of neurotransmitter secretion (GO:0046928)3.16226135
68positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.14997614
69regulation of synaptic transmission, GABAergic (GO:0032228)3.14340113
70membrane depolarization during action potential (GO:0086010)3.14281197
71response to pheromone (GO:0019236)3.12803873
72regulation of synaptic vesicle transport (GO:1902803)3.12105307
73regulation of hippo signaling (GO:0035330)3.11474384
74regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.11329924
75negative regulation of astrocyte differentiation (GO:0048712)3.09550459
76regulation of synaptic plasticity (GO:0048167)3.09078155
77positive regulation of membrane potential (GO:0045838)3.09069682
78dendrite morphogenesis (GO:0048813)3.08069789
79inner ear receptor stereocilium organization (GO:0060122)3.07170257
80central nervous system projection neuron axonogenesis (GO:0021952)3.07010333
81regulation of inositol phosphate biosynthetic process (GO:0010919)3.06355688
82membrane assembly (GO:0071709)3.06253024
83regulation of vesicle fusion (GO:0031338)3.05731606
84synapse assembly (GO:0007416)3.03329156
85membrane depolarization (GO:0051899)3.02968925
86regulation of neuronal synaptic plasticity (GO:0048168)3.02686638
87nonmotile primary cilium assembly (GO:0035058)3.01726208
88renal tubule morphogenesis (GO:0061333)3.01627209
89behavioral defense response (GO:0002209)3.01072469
90behavioral fear response (GO:0001662)3.01072469
91regulation of long-term neuronal synaptic plasticity (GO:0048169)3.00730309
92membrane hyperpolarization (GO:0060081)2.99887198
93phasic smooth muscle contraction (GO:0014821)2.99252497
94gonadal mesoderm development (GO:0007506)2.99197061
95vascular smooth muscle contraction (GO:0014829)2.98731978
96regulation of non-canonical Wnt signaling pathway (GO:2000050)2.98689930
97peristalsis (GO:0030432)2.98487900
98intestinal cholesterol absorption (GO:0030299)2.98193860
99neurotransmitter transport (GO:0006836)2.97609408
100auditory receptor cell stereocilium organization (GO:0060088)2.96383224
101negative regulation of sodium ion transport (GO:0010766)2.95642128
102negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93567890
103synaptic transmission (GO:0007268)2.92592634
104regulation of respiratory gaseous exchange (GO:0043576)2.92551731
105water-soluble vitamin biosynthetic process (GO:0042364)2.92476110
106glycosphingolipid biosynthetic process (GO:0006688)2.90849979
107positive regulation of neurotransmitter secretion (GO:0001956)2.90668904
108amino acid import (GO:0043090)2.90406504
109regulation of glutamate secretion (GO:0014048)2.90339543
110artery smooth muscle contraction (GO:0014824)2.89704883
111L-amino acid import (GO:0043092)2.88939952
112positive regulation of amino acid transport (GO:0051957)2.88424504
113regulation of synapse organization (GO:0050807)2.86458592
114protein complex biogenesis (GO:0070271)2.86447639
115regulation of synaptic transmission (GO:0050804)2.85576676
116positive regulation of fibroblast migration (GO:0010763)2.85513061
117regulation of neurotransmitter transport (GO:0051588)2.84504797
118learning (GO:0007612)2.82930185
119protein polyglutamylation (GO:0018095)2.81453370
120fear response (GO:0042596)2.80430157
121regulation of Rac GTPase activity (GO:0032314)2.79452683
122dendrite development (GO:0016358)2.79110654
123regulation of neurotransmitter levels (GO:0001505)2.78460011
124exploration behavior (GO:0035640)2.78412275
125cell differentiation in hindbrain (GO:0021533)2.78270585
126behavioral response to cocaine (GO:0048148)2.78196706
127innervation (GO:0060384)2.76607078
128nephron tubule morphogenesis (GO:0072078)2.73923727
129nephron epithelium morphogenesis (GO:0072088)2.73923727
130nitric oxide mediated signal transduction (GO:0007263)2.73022503
131atrial cardiac muscle cell action potential (GO:0086014)2.69612046
132axoneme assembly (GO:0035082)2.69584001
133dendritic spine morphogenesis (GO:0060997)2.68349010
134purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.66406955
1353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.66406955
136protein localization to cilium (GO:0061512)2.64665723
137photoreceptor cell maintenance (GO:0045494)2.64023044
138regulation of glucokinase activity (GO:0033131)2.63957045
139regulation of hexokinase activity (GO:1903299)2.63957045
140retinal ganglion cell axon guidance (GO:0031290)2.63662629
141neural tube formation (GO:0001841)2.62767572
142phosphatidylinositol acyl-chain remodeling (GO:0036149)2.61475499
143tonic smooth muscle contraction (GO:0014820)2.60690737
144detection of light stimulus involved in visual perception (GO:0050908)2.59839977
145detection of light stimulus involved in sensory perception (GO:0050962)2.59839977
146regulation of cilium movement (GO:0003352)2.59267249
147detection of mechanical stimulus involved in sensory perception (GO:0050974)2.58618091
148short-term memory (GO:0007614)2.57286156
149limb bud formation (GO:0060174)2.56902765
150pyrimidine nucleobase catabolic process (GO:0006208)2.55074336
151behavioral response to ethanol (GO:0048149)2.53127996
152regulation of timing of cell differentiation (GO:0048505)2.51869833
153mitochondrial respiratory chain complex assembly (GO:0033108)2.51855628
154regulation of dopamine secretion (GO:0014059)2.50221403
155indolalkylamine metabolic process (GO:0006586)2.48087228
156limb development (GO:0060173)2.46227293
157appendage development (GO:0048736)2.46227293
158indole-containing compound catabolic process (GO:0042436)2.43744339
159indolalkylamine catabolic process (GO:0046218)2.43744339
160tryptophan catabolic process (GO:0006569)2.43744339
161lymphangiogenesis (GO:0001946)2.43706429
162mannosylation (GO:0097502)2.42275563
163negative regulation of systemic arterial blood pressure (GO:0003085)2.39188783
164NADH dehydrogenase complex assembly (GO:0010257)2.35764988
165mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.35764988
166mitochondrial respiratory chain complex I assembly (GO:0032981)2.35764988
167regulation of sarcomere organization (GO:0060297)2.34896996
168epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30519863
169cilium organization (GO:0044782)2.29607292
170photoreceptor cell development (GO:0042461)2.29560067
171reverse cholesterol transport (GO:0043691)2.29508735
172cilium assembly (GO:0042384)2.29198240
173cilium morphogenesis (GO:0060271)2.28633735
174fucosylation (GO:0036065)2.27338616
175intraciliary transport (GO:0042073)2.27198093
176respiratory chain complex IV assembly (GO:0008535)2.26519358
177primary amino compound metabolic process (GO:1901160)2.26325790
178phosphatidylserine acyl-chain remodeling (GO:0036150)2.26011888
179dorsal/ventral axis specification (GO:0009950)2.25857559
180cellular ketone body metabolic process (GO:0046950)2.25445811
181response to redox state (GO:0051775)2.22231656
182auditory receptor cell differentiation (GO:0042491)2.21895832
183establishment of pigment granule localization (GO:0051905)2.21590769
184smooth muscle contraction (GO:0006939)2.19985387
185peptidyl-glutamic acid modification (GO:0018200)2.19708055
186signal peptide processing (GO:0006465)2.18358743
187positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.17647676
188response to lipoprotein particle (GO:0055094)2.17592740
189arginine metabolic process (GO:0006525)2.17413805
190retinal cone cell development (GO:0046549)2.17175342
191glycerophospholipid catabolic process (GO:0046475)2.16632601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.41594147
2GBX2_23144817_ChIP-Seq_PC3_Human4.78464604
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04270549
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02668358
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83406043
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.61929640
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60757585
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56860277
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45835198
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45835198
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42147627
12TAF15_26573619_Chip-Seq_HEK293_Human2.41785684
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.40523479
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38529588
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36545850
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33027391
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30871774
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30320446
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27376892
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24513034
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17053613
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15976172
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03097532
24P300_19829295_ChIP-Seq_ESCs_Human1.99535912
25REST_21632747_ChIP-Seq_MESCs_Mouse1.99495242
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.98459877
27DROSHA_22980978_ChIP-Seq_HELA_Human1.98083945
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95604700
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.94098260
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.93633162
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.91882283
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88404499
33SMAD4_21799915_ChIP-Seq_A2780_Human1.86025764
34FUS_26573619_Chip-Seq_HEK293_Human1.84322961
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83897540
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77505250
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.77415200
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.76636485
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76493939
40AR_21572438_ChIP-Seq_LNCaP_Human1.74539220
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71058762
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70083961
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62476279
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.60917354
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56506360
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56458840
47AR_25329375_ChIP-Seq_VCAP_Human1.53138959
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.49926218
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49672856
50VDR_22108803_ChIP-Seq_LS180_Human1.49324162
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.47491277
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46944836
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45742215
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.42824381
55TP53_18474530_ChIP-ChIP_U2OS_Human1.42772588
56CBP_20019798_ChIP-Seq_JUKART_Human1.41856642
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41856642
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41307426
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41177135
60STAT3_23295773_ChIP-Seq_U87_Human1.40353753
61ZNF274_21170338_ChIP-Seq_K562_Hela1.39626970
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39294031
63TCF4_22108803_ChIP-Seq_LS180_Human1.38675212
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.38118671
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.35344920
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34488814
67EWS_26573619_Chip-Seq_HEK293_Human1.33850349
68SOX2_19829295_ChIP-Seq_ESCs_Human1.32457097
69NANOG_19829295_ChIP-Seq_ESCs_Human1.32457097
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31573389
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31269793
72RNF2_27304074_Chip-Seq_NSC_Mouse1.30716526
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30556463
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28548031
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.27657759
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25008694
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.24938759
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24615498
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24350667
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24003852
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.23117737
82TCF4_23295773_ChIP-Seq_U87_Human1.22944521
83JUN_21703547_ChIP-Seq_K562_Human1.22781944
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22078612
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21904703
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21904703
87TP53_22573176_ChIP-Seq_HFKS_Human1.21364714
88SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.21248418
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20451809
90BCAT_22108803_ChIP-Seq_LS180_Human1.19531730
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19393301
92ER_23166858_ChIP-Seq_MCF-7_Human1.19025488
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18730366
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18188878
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.17192865
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16745415
97AHR_22903824_ChIP-Seq_MCF-7_Human1.16641607
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15859329
99RUNX2_22187159_ChIP-Seq_PCA_Human1.15631412
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.13974392
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13923731
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.13296292
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.11118920
104P53_22387025_ChIP-Seq_ESCs_Mouse1.10646870
105CDX2_22108803_ChIP-Seq_LS180_Human1.10410041
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09798002
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09798002
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09505107
109AR_19668381_ChIP-Seq_PC3_Human1.08843557
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08801299
111IGF1R_20145208_ChIP-Seq_DFB_Human1.07788533
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.06771043
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06699935
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06691665
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05307190
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.04751188
117SOX9_26525672_Chip-Seq_HEART_Mouse1.04695334
118TP53_16413492_ChIP-PET_HCT116_Human1.04648740
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03540634
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02032970
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01083823
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.00548726
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00517283
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99652882
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99074258
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99070291
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98894578
128CJUN_26792858_Chip-Seq_BT549_Human0.98571630
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98130163
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97848967
131KDM2B_26808549_Chip-Seq_REH_Human0.96785526
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96699755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08714618
2MP0003880_abnormal_central_pattern4.90077826
3MP0006054_spinal_hemorrhage4.45000615
4MP0003195_calcinosis4.33697238
5MP0003635_abnormal_synaptic_transmissio3.70467638
6MP0001968_abnormal_touch/_nociception3.67611243
7MP0009745_abnormal_behavioral_response3.52629002
8MP0002736_abnormal_nociception_after3.44890861
9MP0009046_muscle_twitch3.41332498
10MP0002064_seizures3.06348272
11MP0002063_abnormal_learning/memory/cond3.00596942
12MP0002572_abnormal_emotion/affect_behav2.99516933
13MP0002735_abnormal_chemical_nociception2.95043747
14MP0005171_absent_coat_pigmentation2.65202180
15MP0001486_abnormal_startle_reflex2.55605875
16MP0002272_abnormal_nervous_system2.53164922
17MP0001188_hyperpigmentation2.46664091
18MP0004270_analgesia2.43699579
19MP0002734_abnormal_mechanical_nocicepti2.36040651
20MP0001440_abnormal_grooming_behavior2.33688125
21MP0002067_abnormal_sensory_capabilities2.27440634
22MP0001501_abnormal_sleep_pattern2.17922920
23MP0000569_abnormal_digit_pigmentation2.16119218
24MP0005423_abnormal_somatic_nervous2.15089833
25MP0002876_abnormal_thyroid_physiology2.04852590
26MP0002938_white_spotting1.97841638
27MP0002733_abnormal_thermal_nociception1.90922160
28MP0005646_abnormal_pituitary_gland1.89236594
29MP0000778_abnormal_nervous_system1.87070393
30MP0001984_abnormal_olfaction1.84570165
31MP0003787_abnormal_imprinting1.83731019
32MP0004142_abnormal_muscle_tone1.80122267
33MP0002822_catalepsy1.79903986
34MP0008875_abnormal_xenobiotic_pharmacok1.78910959
35MP0010368_abnormal_lymphatic_system1.78044235
36MP0002557_abnormal_social/conspecific_i1.77340600
37MP0005167_abnormal_blood-brain_barrier1.75709704
38MP0001970_abnormal_pain_threshold1.75630951
39MP0008569_lethality_at_weaning1.74831131
40MP0001502_abnormal_circadian_rhythm1.74522521
41MP0005085_abnormal_gallbladder_physiolo1.73091737
42MP0002184_abnormal_innervation1.67640366
43MP0004924_abnormal_behavior1.64273864
44MP0005386_behavior/neurological_phenoty1.64273864
45MP0006276_abnormal_autonomic_nervous1.63998121
46MP0001905_abnormal_dopamine_level1.55238535
47MP0005253_abnormal_eye_physiology1.45332037
48MP0010329_abnormal_lipoprotein_level1.41396646
49MP0005084_abnormal_gallbladder_morpholo1.39944944
50MP0003879_abnormal_hair_cell1.39818857
51MP0008877_abnormal_DNA_methylation1.38472027
52MP0001986_abnormal_taste_sensitivity1.36175189
53MP0008775_abnormal_heart_ventricle1.35277509
54MP0000372_irregular_coat_pigmentation1.35058773
55MP0002653_abnormal_ependyma_morphology1.34762064
56MP0001529_abnormal_vocalization1.32255022
57MP0002638_abnormal_pupillary_reflex1.31011359
58MP0003950_abnormal_plasma_membrane1.27986030
59MP0000647_abnormal_sebaceous_gland1.27111223
60MP0005187_abnormal_penis_morphology1.26581634
61MP0004133_heterotaxia1.26487585
62MP0002066_abnormal_motor_capabilities/c1.24495529
63MP0002837_dystrophic_cardiac_calcinosis1.23791016
64MP0002882_abnormal_neuron_morphology1.23081415
65MP0005195_abnormal_posterior_eye1.22009732
66MP0005645_abnormal_hypothalamus_physiol1.22006807
67MP0004215_abnormal_myocardial_fiber1.20465193
68MP0001324_abnormal_eye_pigmentation1.20157056
69MP0003937_abnormal_limbs/digits/tail_de1.20100722
70MP0002233_abnormal_nose_morphology1.20098585
71MP0003122_maternal_imprinting1.19413758
72MP0003136_yellow_coat_color1.18436049
73MP0005360_urolithiasis1.17862462
74MP0000955_abnormal_spinal_cord1.17635965
75MP0005365_abnormal_bile_salt1.14090397
76MP0003283_abnormal_digestive_organ1.11684291
77MP0004811_abnormal_neuron_physiology1.11109854
78MP0005174_abnormal_tail_pigmentation1.10945154
79MP0008789_abnormal_olfactory_epithelium1.09362416
80MP0005408_hypopigmentation1.08791547
81MP0003567_abnormal_fetal_cardiomyocyte1.04087044
82MP0006072_abnormal_retinal_apoptosis1.03838132
83MP0003011_delayed_dark_adaptation1.03769212
84MP0001293_anophthalmia1.02776381
85MP0009780_abnormal_chondrocyte_physiolo1.02209888
86MP0004272_abnormal_basement_membrane1.01514470
87MP0009697_abnormal_copulation1.01012999
88MP0003252_abnormal_bile_duct1.00967159
89MP0003633_abnormal_nervous_system0.99582403
90MP0003718_maternal_effect0.97170026
91MP0006292_abnormal_olfactory_placode0.96935761
92MP0002152_abnormal_brain_morphology0.96277532
93MP0000427_abnormal_hair_cycle0.96260340
94MP0001177_atelectasis0.96229937
95MP0003329_amyloid_beta_deposits0.95831266
96MP0001963_abnormal_hearing_physiology0.94482648
97MP0009384_cardiac_valve_regurgitation0.93921348
98MP0003755_abnormal_palate_morphology0.93167222
99MP0003631_nervous_system_phenotype0.93112588
100MP0002254_reproductive_system_inflammat0.92944850
101MP0010386_abnormal_urinary_bladder0.90814173
102MP0000566_synostosis0.89081190
103MP0004484_altered_response_of0.88913266
104MP0001485_abnormal_pinna_reflex0.88878925
105MP0004858_abnormal_nervous_system0.88450086
106MP0008872_abnormal_physiological_respon0.88300187
107MP0005551_abnormal_eye_electrophysiolog0.87953362
108MP0000639_abnormal_adrenal_gland0.87707209
109MP0005503_abnormal_tendon_morphology0.86867422
110MP0004742_abnormal_vestibular_system0.86015239
111MP0000049_abnormal_middle_ear0.84665039
112MP0003119_abnormal_digestive_system0.84044558
113MP0003137_abnormal_impulse_conducting0.83102677
114MP0000026_abnormal_inner_ear0.82085742
115MP0002069_abnormal_eating/drinking_beha0.81697855
116MP0003632_abnormal_nervous_system0.80948075
117MP0004885_abnormal_endolymph0.80447692
118MP0000751_myopathy0.79878402
119MP0002102_abnormal_ear_morphology0.79393688
120MP0004085_abnormal_heartbeat0.78998355
121MP0004043_abnormal_pH_regulation0.78051939
122MP0005391_vision/eye_phenotype0.77230701
123MP0000383_abnormal_hair_follicle0.77158468
124MP0002160_abnormal_reproductive_system0.76025045
125MP0001879_abnormal_lymphatic_vessel0.75961817
126MP0002752_abnormal_somatic_nervous0.74304816
127MP0005595_abnormal_vascular_smooth0.74012641
128MP0009379_abnormal_foot_pigmentation0.72805921
129MP0003121_genomic_imprinting0.72630968
130MP0008004_abnormal_stomach_pH0.72144841
131MP0000631_abnormal_neuroendocrine_gland0.67970938
132MP0001664_abnormal_digestion0.65848723
133MP0003690_abnormal_glial_cell0.63844641
134MP0002229_neurodegeneration0.63819800
135MP0008874_decreased_physiological_sensi0.61753433
136MP0003646_muscle_fatigue0.61493668
137MP0000013_abnormal_adipose_tissue0.60423977
138MP0001299_abnormal_eye_distance/0.57129748
139MP0002082_postnatal_lethality0.56220547
140MP0010770_preweaning_lethality0.56220547
141MP0003634_abnormal_glial_cell0.54419263
142MP0005623_abnormal_meninges_morphology0.53560922
143MP0010769_abnormal_survival0.53268420
144MP0004145_abnormal_muscle_electrophysio0.51621336
145MP0001943_abnormal_respiration0.50924853
146MP0010768_mortality/aging0.49731162
147MP0002751_abnormal_autonomic_nervous0.49058211
148MP0003183_abnormal_peptide_metabolism0.48995260

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)6.06331044
2Epileptic encephalopathy (HP:0200134)5.87585633
3Atonic seizures (HP:0010819)5.60897993
4Focal seizures (HP:0007359)5.51235620
5Hyperventilation (HP:0002883)4.63708663
6Progressive cerebellar ataxia (HP:0002073)4.19342252
7Dialeptic seizures (HP:0011146)4.07620308
8Myokymia (HP:0002411)4.06504374
9Generalized tonic-clonic seizures (HP:0002069)3.96437732
10Absence seizures (HP:0002121)3.93393715
11Broad-based gait (HP:0002136)3.42661741
12Aplasia involving bones of the extremities (HP:0009825)3.36584335
13Aplasia involving bones of the upper limbs (HP:0009823)3.36584335
14Aplasia of the phalanges of the hand (HP:0009802)3.36584335
15Abnormality of midbrain morphology (HP:0002418)3.36529805
16Molar tooth sign on MRI (HP:0002419)3.36529805
17Gaze-evoked nystagmus (HP:0000640)3.35182819
18Fibular aplasia (HP:0002990)3.32414253
19Type II lissencephaly (HP:0007260)3.27747673
20Abnormality of binocular vision (HP:0011514)3.21828030
21Diplopia (HP:0000651)3.21828030
22Congenital stationary night blindness (HP:0007642)3.17174395
23Pancreatic cysts (HP:0001737)3.09522621
24Protruding tongue (HP:0010808)3.09478270
25Hypothermia (HP:0002045)3.01043397
26Pancreatic fibrosis (HP:0100732)2.98607449
27True hermaphroditism (HP:0010459)2.91987754
28Dysdiadochokinesis (HP:0002075)2.91322614
29Visual hallucinations (HP:0002367)2.90457550
30Abnormal hair whorl (HP:0010721)2.83629529
31Lissencephaly (HP:0001339)2.80971105
32Drooling (HP:0002307)2.76039187
33Excessive salivation (HP:0003781)2.76039187
34Epileptiform EEG discharges (HP:0011182)2.75383220
35Hemiparesis (HP:0001269)2.74576343
36Narrow nasal bridge (HP:0000446)2.74026743
37Abnormality of the renal medulla (HP:0100957)2.71528907
38Renal cortical cysts (HP:0000803)2.67719538
39Abnormality of the renal cortex (HP:0011035)2.66182040
40Truncal ataxia (HP:0002078)2.55179781
41Anophthalmia (HP:0000528)2.52961334
42Abolished electroretinogram (ERG) (HP:0000550)2.50836883
43Hemiplegia (HP:0002301)2.48214114
44Amblyopia (HP:0000646)2.47127932
45Hyperglycinemia (HP:0002154)2.46682810
46Blue irides (HP:0000635)2.45757662
47Gait imbalance (HP:0002141)2.43813850
48Disproportionate short-trunk short stature (HP:0003521)2.43408764
49Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.43034719
50Cerebellar dysplasia (HP:0007033)2.40756982
51EEG with generalized epileptiform discharges (HP:0011198)2.39998802
52Bifid tongue (HP:0010297)2.38476404
53Chorioretinal atrophy (HP:0000533)2.37011237
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.32431577
55Medial flaring of the eyebrow (HP:0010747)2.32044311
56Polyphagia (HP:0002591)2.31577808
57Abnormal eating behavior (HP:0100738)2.31574195
58Scanning speech (HP:0002168)2.31328368
59Intestinal atresia (HP:0011100)2.28443602
60Prolonged partial thromboplastin time (HP:0003645)2.24175797
61Supernumerary spleens (HP:0009799)2.21026012
62Hypsarrhythmia (HP:0002521)2.20160453
63Status epilepticus (HP:0002133)2.19850362
64Congenital primary aphakia (HP:0007707)2.19593178
65Genetic anticipation (HP:0003743)2.19015710
66Optic nerve hypoplasia (HP:0000609)2.17549237
67Epidermoid cyst (HP:0200040)2.16361620
68Inability to walk (HP:0002540)2.13332896
69Humeroradial synostosis (HP:0003041)2.12679734
70Synostosis involving the elbow (HP:0003938)2.12679734
71Abnormality of macular pigmentation (HP:0008002)2.11747560
72Short tibia (HP:0005736)2.10908845
73Postaxial hand polydactyly (HP:0001162)2.10577639
74Postaxial foot polydactyly (HP:0001830)2.08726164
75Scrotal hypoplasia (HP:0000046)2.08491086
76Absent speech (HP:0001344)2.08308355
77Bradycardia (HP:0001662)2.08305194
78Aplasia/Hypoplasia of the tongue (HP:0010295)2.07695633
79Dysmetria (HP:0001310)2.07467504
80Thickened helices (HP:0000391)2.06700177
81Nephrogenic diabetes insipidus (HP:0009806)2.05839785
82Large for gestational age (HP:0001520)2.05240377
83Keratoconus (HP:0000563)2.04857443
84Increased corneal curvature (HP:0100692)2.04857443
85Poor eye contact (HP:0000817)2.03010281
86Abnormality of salivation (HP:0100755)2.00902683
87Broad alveolar ridges (HP:0000187)2.00018089
88Focal motor seizures (HP:0011153)10.4635455
89Action tremor (HP:0002345)1.99934621
90Abnormality of the pubic bones (HP:0003172)1.98611665
91Progressive inability to walk (HP:0002505)1.97200573
92Congenital sensorineural hearing impairment (HP:0008527)1.96151791
93Arthropathy (HP:0003040)1.94634073
94Oligodactyly (hands) (HP:0001180)1.94226021
95Genital tract atresia (HP:0001827)1.92774855
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91555219
97Fair hair (HP:0002286)1.90922487
98Clumsiness (HP:0002312)1.90146381
99Decreased central vision (HP:0007663)1.89675677
100Decreased circulating renin level (HP:0003351)1.89564818
101Vaginal atresia (HP:0000148)1.89487865
102Abnormal social behavior (HP:0012433)1.89023211
103Impaired social interactions (HP:0000735)1.89023211
104Acute encephalopathy (HP:0006846)1.88726353
105Pendular nystagmus (HP:0012043)1.87709644
106Stereotypic behavior (HP:0000733)1.87645494
107Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87542709
108Gastroesophageal reflux (HP:0002020)1.87449921
109Hypoplastic left heart (HP:0004383)1.86683005
110Deep venous thrombosis (HP:0002625)1.84415947
111Widely spaced teeth (HP:0000687)1.83456815
112Concave nail (HP:0001598)1.82055936
113Absent hair (HP:0002298)1.80697482
114Hyperglycinuria (HP:0003108)1.80494117
115Sclerocornea (HP:0000647)1.80461314
116Renal hypoplasia (HP:0000089)1.78765646
117Dynein arm defect of respiratory motile cilia (HP:0012255)1.78740231
118Absent/shortened dynein arms (HP:0200106)1.78740231
119Specific learning disability (HP:0001328)1.77920539
120Prominent supraorbital ridges (HP:0000336)1.77499333
121Limb dystonia (HP:0002451)1.77145875
122Megalencephaly (HP:0001355)1.74030910
123Absent eyebrow (HP:0002223)1.73640025
124Rib fusion (HP:0000902)1.73391512
125Attenuation of retinal blood vessels (HP:0007843)1.73040450
126Volvulus (HP:0002580)1.71844318
127Abnormality of glycine metabolism (HP:0010895)1.71420553
128Abnormality of serine family amino acid metabolism (HP:0010894)1.71420553
129Increased circulating renin level (HP:0000848)1.70895707
130Poor suck (HP:0002033)1.70448410
131Abnormal rod and cone electroretinograms (HP:0008323)1.69296713
132Decreased muscle mass (HP:0003199)1.69154700
133Bulbous nose (HP:0000414)1.68675720
134Cystic liver disease (HP:0006706)1.68612283
135Thyroid-stimulating hormone excess (HP:0002925)1.68371555
136Poor coordination (HP:0002370)1.68148130
137Chronic hepatic failure (HP:0100626)1.67710132
138Pachygyria (HP:0001302)1.67668025
139Deeply set eye (HP:0000490)1.67407588
140Impaired smooth pursuit (HP:0007772)1.66583514
141Myelomeningocele (HP:0002475)1.66055048
142Dental crowding (HP:0000678)1.66028464
143Anxiety (HP:0000739)1.65268094
144Generalized myoclonic seizures (HP:0002123)1.65123470
145Abnormality of alanine metabolism (HP:0010916)1.65011394
146Hyperalaninemia (HP:0003348)1.65011394
147Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65011394
148Impaired vibration sensation in the lower limbs (HP:0002166)1.64720544
149Aplasia/Hypoplasia of the lens (HP:0008063)1.63768676
150Retinal dysplasia (HP:0007973)1.63682121
151Short foot (HP:0001773)1.63556905
152Nephronophthisis (HP:0000090)1.63514906
153Abnormal biliary tract physiology (HP:0012439)1.63240268
154Bile duct proliferation (HP:0001408)1.63240268
155Tracheomalacia (HP:0002779)1.62856553
156Abnormality of the labia minora (HP:0012880)1.62812372
157Morphological abnormality of the middle ear (HP:0008609)1.62773535
158Abnormality of the vitreous humor (HP:0004327)1.61264073
159Acute necrotizing encephalopathy (HP:0006965)1.61145421
160Narrow forehead (HP:0000341)1.61085866
161Progressive macrocephaly (HP:0004481)1.60817126
162Generalized hypopigmentation of hair (HP:0011358)1.60041281
163Hypoplastic heart (HP:0001961)1.59642859
164Aplasia/Hypoplasia of the fibula (HP:0006492)1.59298444
165Gait ataxia (HP:0002066)1.58996021
166Absent eyelashes (HP:0000561)1.58512482
167Dysmetric saccades (HP:0000641)1.56648997
168Dyskinesia (HP:0100660)1.55082085
169Fetal akinesia sequence (HP:0001989)1.54438222
170Atrioventricular canal defect (HP:0006695)1.53882243

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.15038599
2NTRK35.01922413
3EPHA44.73157597
4MAP2K74.01161819
5MAP3K43.45648375
6TNIK3.20173001
7MAP4K22.88525211
8GRK12.64726447
9WNK32.59761955
10TIE12.47462092
11AKT32.39926821
12WNK42.37259173
13NTRK22.27097350
14MAP2K41.96188915
15MAP3K121.95279741
16CCNB11.92692634
17PRPF4B1.90956371
18PLK21.80835443
19MARK11.74913154
20MAPK131.74368643
21STK391.62770967
22MINK11.62232006
23MUSK1.60558617
24CDK191.57948998
25FES1.55001988
26MAP3K61.54783862
27NUAK11.53478175
28DAPK21.53000142
29SGK21.50580580
30EPHB21.46772863
31FER1.43456201
32DAPK11.28940086
33NLK1.28482425
34STK38L1.25324605
35CAMK2A1.23146963
36PRKCG1.21857705
37CSNK1A1L1.15650196
38CSNK1G11.13810810
39SGK2231.13020947
40SGK4941.13020947
41DYRK21.12767984
42CDK51.07181656
43CAMK2B1.06304058
44CSNK1G31.05116385
45OXSR11.04625507
46MAP3K91.03570102
47PLK31.03565812
48PRKCE1.03033310
49SIK21.02336164
50CDK81.01917474
51TRIM280.97831481
52SIK30.95636239
53MKNK10.95022026
54NME10.91080798
55ADRBK10.89481447
56MAPKAPK50.88024203
57MKNK20.86981489
58NEK90.86732492
59GRK50.85154130
60PHKG10.82606735
61PHKG20.82606735
62ACVR1B0.81754611
63SGK30.81691561
64INSRR0.78590036
65STK380.77782246
66FGFR20.77637580
67DYRK1A0.77273081
68BMPR1B0.75978176
69BRAF0.74735137
70FGFR10.74693642
71CSNK1G20.74359907
72ERBB40.74317214
73CAMKK20.74248975
74KSR10.72458206
75PTK2B0.72027241
76PLK40.71932900
77SGK10.71406525
78DDR20.70882898
79CDK30.69892470
80FGR0.69071263
81EPHA30.69056576
82MAPK120.66917652
83BRSK20.66646996
84VRK10.66526167
85PIK3CA0.64560362
86CDK180.61077916
87MARK20.60607151
88ERBB20.59901750
89CAMK2D0.59142306
90MET0.58090899
91PRKAA20.58049749
92CDK150.56568775
93ZAK0.55650265
94GRK70.53866438
95MAPK70.51803020
96CAMK2G0.51690025
97BMPR20.51532117
98NEK10.51505349
99TYRO30.51489354
100NTRK10.51273892
101TAF10.50622660
102CDK140.49555952
103FLT30.49490456
104TSSK60.49145675
105CDC42BPA0.49102990
106PRKG10.48359843
107MYLK0.47758562
108BCKDK0.47648106
109PAK30.46778205
110CDK11A0.46644462
111KDR0.46048787
112YES10.45593794
113ROCK10.45350542
114BCR0.44766739
115TAOK20.44138149
116MAP3K130.44014960
117TXK0.43573531
118PAK60.43390189
119PRKACA0.43349084
120ADRBK20.43104003
121PNCK0.42715396
122IGF1R0.42003655
123ERBB30.41019368
124NEK60.40837395
125STK110.40530709
126CAMK10.40072518
127PRKCQ0.40011791
128CAMKK10.39205697
129PLK10.38246648
130EIF2AK30.38041970
131EIF2AK20.37551286
132TGFBR10.36704821
133CSNK1D0.36400925
134PRKCZ0.35195168
135PRKCA0.34492166
136RPS6KB10.34326696
137FRK0.34041489
138MAP2K10.33808047
139PINK10.32190339
140PKN10.32180410
141STK160.32044772
142PRKACB0.31789451
143LATS10.31530247
144PRKAA10.31374705
145CSNK1E0.30570278
146EIF2AK10.30508351
147PRKCB0.30494294
148PIM20.30349873
149RPS6KA30.29763987
150PRKACG0.28680793
151CSNK1A10.27778878
152RIPK40.27473835
153LIMK10.27432344

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.07098881
2Synaptic vesicle cycle_Homo sapiens_hsa047213.39676020
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.17206098
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.98272836
5GABAergic synapse_Homo sapiens_hsa047272.95553396
6Circadian entrainment_Homo sapiens_hsa047132.85916380
7Nitrogen metabolism_Homo sapiens_hsa009102.75345896
8Morphine addiction_Homo sapiens_hsa050322.75155128
9Glutamatergic synapse_Homo sapiens_hsa047242.74782147
10Long-term potentiation_Homo sapiens_hsa047202.61597142
11Linoleic acid metabolism_Homo sapiens_hsa005912.57850984
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54328841
13Collecting duct acid secretion_Homo sapiens_hsa049662.37356159
14Steroid biosynthesis_Homo sapiens_hsa001002.37223739
15Amphetamine addiction_Homo sapiens_hsa050312.28962819
16Taste transduction_Homo sapiens_hsa047422.28406929
17Protein export_Homo sapiens_hsa030602.19199475
18Propanoate metabolism_Homo sapiens_hsa006402.11109162
19Olfactory transduction_Homo sapiens_hsa047402.08353085
20Serotonergic synapse_Homo sapiens_hsa047262.08136716
21Ether lipid metabolism_Homo sapiens_hsa005652.06169341
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96989996
23Fat digestion and absorption_Homo sapiens_hsa049751.96203453
24Dopaminergic synapse_Homo sapiens_hsa047281.93295515
25Long-term depression_Homo sapiens_hsa047301.91847689
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88662907
27Calcium signaling pathway_Homo sapiens_hsa040201.85233149
28Complement and coagulation cascades_Homo sapiens_hsa046101.84670125
29Salivary secretion_Homo sapiens_hsa049701.77083294
30Insulin secretion_Homo sapiens_hsa049111.74739591
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71380955
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.55284931
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55224041
34Cholinergic synapse_Homo sapiens_hsa047251.53715013
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52149992
36Renin secretion_Homo sapiens_hsa049241.51315582
37Cocaine addiction_Homo sapiens_hsa050301.49776743
38Peroxisome_Homo sapiens_hsa041461.49518156
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48584348
40Basal transcription factors_Homo sapiens_hsa030221.46755333
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.43734327
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38841580
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.37344768
44Oxidative phosphorylation_Homo sapiens_hsa001901.36072655
45Circadian rhythm_Homo sapiens_hsa047101.33931984
46Oxytocin signaling pathway_Homo sapiens_hsa049211.33106361
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32769734
48Gastric acid secretion_Homo sapiens_hsa049711.32570496
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32145104
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31405748
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31220604
52Selenocompound metabolism_Homo sapiens_hsa004501.29031125
53Vibrio cholerae infection_Homo sapiens_hsa051101.27866084
54cAMP signaling pathway_Homo sapiens_hsa040241.27734950
55Chemical carcinogenesis_Homo sapiens_hsa052041.24138788
56Axon guidance_Homo sapiens_hsa043601.23666776
57Retinol metabolism_Homo sapiens_hsa008301.21262329
58ABC transporters_Homo sapiens_hsa020101.16360088
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13023433
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11842082
61Tryptophan metabolism_Homo sapiens_hsa003801.09663905
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07586859
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04136259
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02152798
65Cardiac muscle contraction_Homo sapiens_hsa042601.02104236
66Gap junction_Homo sapiens_hsa045401.01847383
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99678122
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95482681
69Alzheimers disease_Homo sapiens_hsa050100.95266561
70Arachidonic acid metabolism_Homo sapiens_hsa005900.95162599
71GnRH signaling pathway_Homo sapiens_hsa049120.95007072
72Fatty acid elongation_Homo sapiens_hsa000620.94848813
73Type II diabetes mellitus_Homo sapiens_hsa049300.93054607
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92296093
75Fatty acid degradation_Homo sapiens_hsa000710.91578309
76Starch and sucrose metabolism_Homo sapiens_hsa005000.90444806
77Fatty acid metabolism_Homo sapiens_hsa012120.89615548
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88872850
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88645280
80beta-Alanine metabolism_Homo sapiens_hsa004100.88272665
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88087332
82ErbB signaling pathway_Homo sapiens_hsa040120.87605475
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.85730693
84Dilated cardiomyopathy_Homo sapiens_hsa054140.84944507
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81844445
86Glycerolipid metabolism_Homo sapiens_hsa005610.80892517
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80244111
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78861800
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78326798
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76525439
91Histidine metabolism_Homo sapiens_hsa003400.75426794
92Rheumatoid arthritis_Homo sapiens_hsa053230.75076494
93Phototransduction_Homo sapiens_hsa047440.75044056
94Type I diabetes mellitus_Homo sapiens_hsa049400.74745095
95Estrogen signaling pathway_Homo sapiens_hsa049150.74641080
96Sulfur metabolism_Homo sapiens_hsa009200.74510993
97Melanogenesis_Homo sapiens_hsa049160.73470525
98Hippo signaling pathway_Homo sapiens_hsa043900.72912536
99PPAR signaling pathway_Homo sapiens_hsa033200.71255456
100Vitamin digestion and absorption_Homo sapiens_hsa049770.70192845
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69764101
102Parkinsons disease_Homo sapiens_hsa050120.67830276
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67029110
104Regulation of autophagy_Homo sapiens_hsa041400.66347980
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64828701
106Basal cell carcinoma_Homo sapiens_hsa052170.61020202
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60350690
108Fatty acid biosynthesis_Homo sapiens_hsa000610.59437524
109MAPK signaling pathway_Homo sapiens_hsa040100.58893518
110Ras signaling pathway_Homo sapiens_hsa040140.58456617
111Huntingtons disease_Homo sapiens_hsa050160.58357453
112RNA degradation_Homo sapiens_hsa030180.57959976
113N-Glycan biosynthesis_Homo sapiens_hsa005100.56732154
114Glioma_Homo sapiens_hsa052140.55662391
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55345727
116Metabolic pathways_Homo sapiens_hsa011000.55096576
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54535682
118Caffeine metabolism_Homo sapiens_hsa002320.54475673
119Wnt signaling pathway_Homo sapiens_hsa043100.53619502
120Phagosome_Homo sapiens_hsa041450.53461680
121Arginine and proline metabolism_Homo sapiens_hsa003300.52596778
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.52331090
123Choline metabolism in cancer_Homo sapiens_hsa052310.51992904
124Melanoma_Homo sapiens_hsa052180.51719191
125Fanconi anemia pathway_Homo sapiens_hsa034600.50458619
126Rap1 signaling pathway_Homo sapiens_hsa040150.49727150
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49489209
128Hedgehog signaling pathway_Homo sapiens_hsa043400.49319448
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48469910
130Pancreatic secretion_Homo sapiens_hsa049720.47804515
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.46934950
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46686110
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45528175
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43673100
135Sphingolipid metabolism_Homo sapiens_hsa006000.40721431
136Sulfur relay system_Homo sapiens_hsa041220.40251050
137Ovarian steroidogenesis_Homo sapiens_hsa049130.39241138
138African trypanosomiasis_Homo sapiens_hsa051430.39114194
139Mineral absorption_Homo sapiens_hsa049780.38170448
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35970897
141Glucagon signaling pathway_Homo sapiens_hsa049220.33413354
142Thyroid hormone synthesis_Homo sapiens_hsa049180.33411300
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32974470
144Butanoate metabolism_Homo sapiens_hsa006500.28783295
145Inositol phosphate metabolism_Homo sapiens_hsa005620.27558321
146Alcoholism_Homo sapiens_hsa050340.27465658
147Pyruvate metabolism_Homo sapiens_hsa006200.26237152
148Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23548180
149Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23081913
150Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22580552
151Oocyte meiosis_Homo sapiens_hsa041140.21625949
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18163931
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17455573
154Dorso-ventral axis formation_Homo sapiens_hsa043200.16489250
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.16341479
156ECM-receptor interaction_Homo sapiens_hsa045120.14825502

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