PTDSS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.13077740
2central nervous system myelination (GO:0022010)5.13077740
3DNA unwinding involved in DNA replication (GO:0006268)5.00926071
4fatty acid elongation (GO:0030497)4.88211682
5nuclear pore complex assembly (GO:0051292)4.49640695
6C4-dicarboxylate transport (GO:0015740)4.37287666
7cholesterol biosynthetic process (GO:0006695)4.23549601
8COPI coating of Golgi vesicle (GO:0048205)4.23495585
9Golgi transport vesicle coating (GO:0048200)4.23495585
10pinocytosis (GO:0006907)4.07663909
11formation of translation preinitiation complex (GO:0001731)4.06449631
12nuclear pore organization (GO:0006999)3.99283923
13regulation of cholesterol homeostasis (GO:2000188)3.99242920
14DNA strand elongation involved in DNA replication (GO:0006271)3.93946185
15protein maturation by protein folding (GO:0022417)3.84224569
16L-amino acid import (GO:0043092)3.83727927
17DNA strand elongation (GO:0022616)3.83378609
18mitotic chromosome condensation (GO:0007076)3.83112989
19L-phenylalanine catabolic process (GO:0006559)3.78793155
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.78793155
21alpha-linolenic acid metabolic process (GO:0036109)3.74319769
22pore complex assembly (GO:0046931)3.72200528
23sterol biosynthetic process (GO:0016126)3.70586418
24positive regulation of lipoprotein lipase activity (GO:0051006)3.68560222
25positive regulation of triglyceride lipase activity (GO:0061365)3.68560222
26ribosomal small subunit biogenesis (GO:0042274)3.64380599
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.62986737
28L-phenylalanine metabolic process (GO:0006558)3.62986737
29negative regulation of digestive system process (GO:0060457)3.61643178
30amino acid import (GO:0043090)3.58578368
31long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.55749821
32regulation of translational fidelity (GO:0006450)3.52291407
33nucleobase-containing small molecule interconversion (GO:0015949)3.49772678
34regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.49311274
35long-chain fatty acid biosynthetic process (GO:0042759)3.47333094
36positive regulation of triglyceride biosynthetic process (GO:0010867)3.44399244
37cysteine metabolic process (GO:0006534)3.43313845
38positive regulation of fatty acid biosynthetic process (GO:0045723)3.40320130
39fatty-acyl-CoA biosynthetic process (GO:0046949)3.39470634
40DNA replication initiation (GO:0006270)3.38403330
41telomere maintenance via semi-conservative replication (GO:0032201)3.34831833
42very long-chain fatty acid metabolic process (GO:0000038)3.34607211
43cellular copper ion homeostasis (GO:0006878)3.32750017
44acyl-CoA biosynthetic process (GO:0071616)3.29132208
45thioester biosynthetic process (GO:0035384)3.29132208
46maturation of SSU-rRNA (GO:0030490)3.25609145
47negative regulation of B cell mediated immunity (GO:0002713)3.18811499
48negative regulation of immunoglobulin mediated immune response (GO:0002890)3.18811499
49myelination (GO:0042552)3.18585719
50cellular ketone body metabolic process (GO:0046950)3.17945536
51ensheathment of neurons (GO:0007272)3.16797808
52axon ensheathment (GO:0008366)3.16797808
53pentose-phosphate shunt (GO:0006098)3.15759632
54proline biosynthetic process (GO:0006561)3.15475195
55spliceosomal tri-snRNP complex assembly (GO:0000244)3.14453178
56L-serine transport (GO:0015825)3.13163492
57L-serine metabolic process (GO:0006563)3.11381349
58pyrimidine nucleobase catabolic process (GO:0006208)3.09810189
59ribosome biogenesis (GO:0042254)3.09321030
60triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.07980424
61long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.07401675
62ribosome assembly (GO:0042255)3.07323334
63ribonucleoprotein complex biogenesis (GO:0022613)3.06109143
64glutamate metabolic process (GO:0006536)3.05074468
65fatty-acyl-CoA metabolic process (GO:0035337)2.98938529
66sulfur amino acid catabolic process (GO:0000098)2.96416602
67amino-acid betaine metabolic process (GO:0006577)2.96105607
68neuron cell-cell adhesion (GO:0007158)2.95782648
69linoleic acid metabolic process (GO:0043651)2.95081418
70transcytosis (GO:0045056)2.94869847
71creatine metabolic process (GO:0006600)2.94107752
72establishment of integrated proviral latency (GO:0075713)2.89991292
73ribosomal small subunit assembly (GO:0000028)2.88764136
74regulation of translational termination (GO:0006449)2.88329606
75heme transport (GO:0015886)2.87795079
76positive regulation of triglyceride metabolic process (GO:0090208)2.87636674
77mitotic nuclear envelope disassembly (GO:0007077)2.87167146
783-UTR-mediated mRNA stabilization (GO:0070935)2.85621416
79serine family amino acid biosynthetic process (GO:0009070)2.84972241
80DNA topological change (GO:0006265)2.84006080
81DNA duplex unwinding (GO:0032508)2.82786592
82dosage compensation (GO:0007549)2.79754758
83folic acid-containing compound biosynthetic process (GO:0009396)2.78797347
84telomere maintenance via recombination (GO:0000722)2.78763936
85short-chain fatty acid metabolic process (GO:0046459)2.78484765
86dicarboxylic acid biosynthetic process (GO:0043650)2.77902711
87proteasome assembly (GO:0043248)2.77685709
88ketone body metabolic process (GO:1902224)2.76189568
89ribosomal large subunit biogenesis (GO:0042273)2.74225937
90peptidyl-arginine omega-N-methylation (GO:0035247)2.73470074
91chaperone mediated protein folding requiring cofactor (GO:0051085)2.72798937
92mitotic nuclear envelope reassembly (GO:0007084)2.72228834
93nuclear envelope reassembly (GO:0031468)2.72228834
94triglyceride biosynthetic process (GO:0019432)2.71842789
95nuclear envelope disassembly (GO:0051081)2.71727777
96membrane disassembly (GO:0030397)2.71727777
97establishment of mitochondrion localization (GO:0051654)2.71178686
98mitotic recombination (GO:0006312)2.70550844
99CDP-diacylglycerol metabolic process (GO:0046341)2.68928064
100substantia nigra development (GO:0021762)2.67750463
101nucleobase catabolic process (GO:0046113)2.67422880
102folic acid metabolic process (GO:0046655)2.67059262
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66812981
104NADPH regeneration (GO:0006740)2.66640248
105DNA geometric change (GO:0032392)2.64252237
106viral transcription (GO:0019083)2.64202849
107pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.64072846
108neutral lipid biosynthetic process (GO:0046460)2.63619404
109acylglycerol biosynthetic process (GO:0046463)2.63619404
110glyoxylate metabolic process (GO:0046487)2.63218485
111carnitine metabolic process (GO:0009437)2.61701741
112mitochondrial fusion (GO:0008053)2.60371002
113glucose catabolic process (GO:0006007)2.60323909
114retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59217239
115deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59000103
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.58799267
117plasma lipoprotein particle clearance (GO:0034381)2.58381553
118nucleoside diphosphate biosynthetic process (GO:0009133)2.58202861
119protein localization to chromosome, centromeric region (GO:0071459)2.57963458
120positive regulation of B cell differentiation (GO:0045579)2.57747262
121regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57514015
122ethanol oxidation (GO:0006069)2.56983379
123negative regulation of erythrocyte differentiation (GO:0045647)2.56747864
124UV protection (GO:0009650)2.56001209
125mitotic sister chromatid segregation (GO:0000070)2.55339781
126aromatic amino acid family catabolic process (GO:0009074)2.55282431
127mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.55142580
128isoprenoid biosynthetic process (GO:0008299)2.54765444
129aspartate family amino acid catabolic process (GO:0009068)2.54293459
130copper ion homeostasis (GO:0055070)2.53938952
131translational termination (GO:0006415)2.53156777
132pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.51020659
133acidic amino acid transport (GO:0015800)2.50997682
134nuclear envelope organization (GO:0006998)2.50238392
135regulation of triglyceride biosynthetic process (GO:0010866)2.49994236
136cholesterol metabolic process (GO:0008203)2.49989998
137acyl-CoA metabolic process (GO:0006637)2.49911535
138thioester metabolic process (GO:0035383)2.49911535
139maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49160344
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.48331172
141serine family amino acid metabolic process (GO:0009069)2.47468646
142serine transport (GO:0032329)2.46810870
143virion attachment to host cell (GO:0019062)2.45691474
144adhesion of symbiont to host cell (GO:0044650)2.45691474
145acetyl-CoA metabolic process (GO:0006084)2.45584986
146positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.45318008
147intestinal cholesterol absorption (GO:0030299)2.44474660
148translational initiation (GO:0006413)2.44386075
149translational elongation (GO:0006414)2.44135644
150purine nucleobase biosynthetic process (GO:0009113)2.43289375
151ethanol metabolic process (GO:0006067)2.42998028
152neurotransmitter uptake (GO:0001504)2.42510301
153SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.42445845
154establishment of viral latency (GO:0019043)2.41624369
155response to peptidoglycan (GO:0032494)2.41119903
156protein export from nucleus (GO:0006611)2.39765930
157cellular modified amino acid catabolic process (GO:0042219)2.39639363
158iron coordination entity transport (GO:1901678)2.39495189
159negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.39246065
160response to food (GO:0032094)2.38276146
161L-glutamate transport (GO:0015813)2.37733100
162response to methylmercury (GO:0051597)2.37670525
163dicarboxylic acid catabolic process (GO:0043649)2.37457375
164triglyceride homeostasis (GO:0070328)2.37022480
165acylglycerol homeostasis (GO:0055090)2.37022480
166apical protein localization (GO:0045176)2.36757490
167DNA conformation change (GO:0071103)2.36710110
168ceramide biosynthetic process (GO:0046513)2.36686241
169response to pheromone (GO:0019236)2.36629753
170NADH metabolic process (GO:0006734)2.36164135
171mitochondrial DNA metabolic process (GO:0032042)2.35951959
172bile acid biosynthetic process (GO:0006699)2.35467744
173protein targeting to ER (GO:0045047)2.35458033
174protein localization to endosome (GO:0036010)2.35239349
175nucleobase biosynthetic process (GO:0046112)2.35213262
176protein complex localization (GO:0031503)2.34636616
177rRNA transcription (GO:0009303)2.34635025
178protein retention in ER lumen (GO:0006621)2.34466623
179cotranslational protein targeting to membrane (GO:0006613)2.33259658
180deoxyribonucleotide biosynthetic process (GO:0009263)2.32938606
181regulation of superoxide anion generation (GO:0032928)2.32510086
182establishment of protein localization to endoplasmic reticulum (GO:0072599)2.32500522
183viral mRNA export from host cell nucleus (GO:0046784)2.32352195
184cellular protein complex localization (GO:0034629)2.31436877
185fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.30862417
186sister chromatid segregation (GO:0000819)2.30643203
187ADP metabolic process (GO:0046031)2.30274823
188tricarboxylic acid cycle (GO:0006099)2.28836424
189IMP biosynthetic process (GO:0006188)2.27065740
190protein localization to endoplasmic reticulum (GO:0070972)2.26919600
191hyaluronan catabolic process (GO:0030214)2.26298074
192negative regulation of necroptotic process (GO:0060546)2.25478393
193glucocorticoid receptor signaling pathway (GO:0042921)2.22580422
194peptidyl-arginine N-methylation (GO:0035246)2.22436411
195peptidyl-arginine methylation (GO:0018216)2.22436411
196tRNA aminoacylation for protein translation (GO:0006418)2.22398506
197positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.22303877
198mRNA stabilization (GO:0048255)2.21017098
199RNA stabilization (GO:0043489)2.21017098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.48872316
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.43945907
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.91272084
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66658424
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.55505261
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.31299667
7CLOCK_20551151_ChIP-Seq_293T_Human2.88911519
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.88091946
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.88042504
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80050898
11MYC_22102868_ChIP-Seq_BL_Human2.77666607
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.75613280
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.67125016
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.51244191
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.49038900
16VDR_21846776_ChIP-Seq_THP-1_Human2.40360099
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39741958
18* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28304349
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24078493
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18530348
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18083604
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16870910
23ZNF263_19887448_ChIP-Seq_K562_Human2.16839049
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14130051
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08981522
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05006288
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99804801
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98969630
29* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97385324
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96953555
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94591826
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93701453
33ZNF274_21170338_ChIP-Seq_K562_Hela1.89203765
34* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.88130150
35TAF15_26573619_Chip-Seq_HEK293_Human1.84005175
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83253591
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82012416
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80735481
39XRN2_22483619_ChIP-Seq_HELA_Human1.80554677
40* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77813817
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.76712765
42* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74945835
43* DCP1A_22483619_ChIP-Seq_HELA_Human1.74118955
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.72850637
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69851997
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67282531
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63536942
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62010572
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61543275
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61433654
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.54730134
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54419748
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54048601
54SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53660265
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52401178
56* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51802601
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50794255
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50300147
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49819638
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49521613
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48989199
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48740099
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.48634425
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48271456
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47935112
66AR_21909140_ChIP-Seq_LNCAP_Human1.46278508
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46140918
68TFEB_21752829_ChIP-Seq_HELA_Human1.45211415
69GABP_19822575_ChIP-Seq_HepG2_Human1.44205984
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43234150
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42877098
72HTT_18923047_ChIP-ChIP_STHdh_Human1.42256577
73* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41995301
74SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.41426090
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39117307
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38762020
77* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38170495
78EOMES_21245162_ChIP-Seq_HESCs_Human1.37333720
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37332908
80* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36194224
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35850493
82VDR_24763502_ChIP-Seq_THP-1_Human1.35631496
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35507704
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.34976547
85KDM5A_27292631_Chip-Seq_BREAST_Human1.33780750
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32793355
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32470739
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32283887
89CIITA_25753668_ChIP-Seq_RAJI_Human1.32276527
90MAF_26560356_Chip-Seq_TH1_Human1.32169320
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31745265
92TTF2_22483619_ChIP-Seq_HELA_Human1.30630460
93* SPI1_23547873_ChIP-Seq_NB4_Human1.30589833
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.30507519
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27673111
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27673111
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25545234
98* FOXP3_21729870_ChIP-Seq_TREG_Human1.25399749
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25202672
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24450317
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24358585
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.23018043
103REST_18959480_ChIP-ChIP_MESCs_Mouse1.21430986
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20586416
105EZH2_27294783_Chip-Seq_ESCs_Mouse1.20425858
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20317362
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18591462
108AR_21572438_ChIP-Seq_LNCaP_Human1.18228011
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17889381
110CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16558524
111NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16236487
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.16193000
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16097137
114RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16039148
115NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15803113
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15669086
117RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15525068
118EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15525068
119STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15431847
120TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.14940216
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.14733199
122RUNX1_22412390_ChIP-Seq_EML_Mouse1.14599609
123ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13880604
124EED_16625203_ChIP-ChIP_MESCs_Mouse1.13202607
125UTX_26944678_Chip-Seq_JUKART_Human1.13021278
126LXR_22292898_ChIP-Seq_THP-1_Human1.11519742
127SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11496938
128YY1_21170310_ChIP-Seq_MESCs_Mouse1.11433915
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11334828
130SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10275230
131GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10198829
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10113454
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09984725
134TCF7_22412390_ChIP-Seq_EML_Mouse1.09894819
135BP1_19119308_ChIP-ChIP_Hs578T_Human1.08493568
136JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08201958
137REST_21632747_ChIP-Seq_MESCs_Mouse1.07902785
138CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07364721
139PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07276070
140MAF_26560356_Chip-Seq_TH2_Human1.07123935
141EST1_17652178_ChIP-ChIP_JURKAT_Human1.05833585
142JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04171191
143FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03670819
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03647867
145* VDR_23849224_ChIP-Seq_CD4+_Human1.03616369
146DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03497750
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02795879
148SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02775640
149NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02307468
150STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01911227
151EZH2_22144423_ChIP-Seq_EOC_Human1.01451031
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01170277
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01063168
154SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01052205
155* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99857680
156AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99795991
157CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99437924
158RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98888273
159SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97955555
160RACK7_27058665_Chip-Seq_MCF-7_Human0.97608579
161NCOR_22424771_ChIP-Seq_293T_Human0.97079677
162SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96505181
163NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94588059
164ER_23166858_ChIP-Seq_MCF-7_Human0.94066937
165GATA1_22025678_ChIP-Seq_K562_Human0.93169779
166ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91562922
167SOX2_20726797_ChIP-Seq_SW620_Human0.91349577
168FOXH1_21741376_ChIP-Seq_ESCs_Human0.91160436
169HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89861596
170PIAS1_25552417_ChIP-Seq_VCAP_Human0.89427029
171GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88904831
172SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88143785
173EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87359160
174EZH2_27304074_Chip-Seq_ESCs_Mouse0.85990963
175FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85725855
176P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84964947
177PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84796884
178TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84674449
179RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83541485
180RARB_27405468_Chip-Seq_BRAIN_Mouse0.83540519
181AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83424569
182FOXO3_23340844_ChIP-Seq_DLD1_Human0.83402680
183NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81541052
184NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77744185
185MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76167244
186NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75341778
187TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74728590
188NR3C1_21868756_ChIP-Seq_MCF10A_Human0.74482053
189GATA4_25053715_ChIP-Seq_YYC3_Human0.73737149
190REST_19997604_ChIP-ChIP_NEURONS_Mouse0.72458203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.92049835
2MP0003329_amyloid_beta_deposits5.44969376
3MP0009840_abnormal_foam_cell4.34896843
4MP0000604_amyloidosis3.60157322
5MP0002877_abnormal_melanocyte_morpholog3.58244809
6MP0005360_urolithiasis3.36134604
7MP0005365_abnormal_bile_salt3.06987689
8MP0003191_abnormal_cellular_cholesterol3.02861652
9MP0003806_abnormal_nucleotide_metabolis2.94084753
10MP0003111_abnormal_nucleus_morphology2.84117513
11MP0000920_abnormal_myelination2.74634055
12MP0010094_abnormal_chromosome_stability2.73909239
13MP0002396_abnormal_hematopoietic_system2.70918704
14MP0003693_abnormal_embryo_hatching2.68012961
15MP0003690_abnormal_glial_cell2.50029925
16MP0003880_abnormal_central_pattern2.41766004
17MP0008875_abnormal_xenobiotic_pharmacok2.39607423
18MP0004957_abnormal_blastocyst_morpholog2.38444510
19MP0003077_abnormal_cell_cycle2.28991267
20MP0004270_analgesia2.25763572
21MP0008057_abnormal_DNA_replication2.15383637
22MP0003763_abnormal_thymus_physiology2.14345294
23MP0005085_abnormal_gallbladder_physiolo2.12826128
24MP0004233_abnormal_muscle_weight2.01995154
25MP0003705_abnormal_hypodermis_morpholog1.98033985
26MP0008007_abnormal_cellular_replicative1.96557771
27MP0003566_abnormal_cell_adhesion1.93393815
28MP0005332_abnormal_amino_acid1.89499798
29MP0004808_abnormal_hematopoietic_stem1.88013657
30MP0001666_abnormal_nutrient_absorption1.86148002
31MP0010329_abnormal_lipoprotein_level1.81773967
32MP0001835_abnormal_antigen_presentation1.80549047
33MP0005058_abnormal_lysosome_morphology1.79471371
34MP0008932_abnormal_embryonic_tissue1.74552557
35MP0003634_abnormal_glial_cell1.73040735
36MP0009384_cardiac_valve_regurgitation1.69176060
37MP0000350_abnormal_cell_proliferation1.69123370
38MP0009333_abnormal_splenocyte_physiolog1.63596355
39MP0005464_abnormal_platelet_physiology1.60448823
40MP0010352_gastrointestinal_tract_polyps1.59671276
41MP0000747_muscle_weakness1.58516192
42MP0001730_embryonic_growth_arrest1.56832440
43MP0005076_abnormal_cell_differentiation1.55587086
44MP0010234_abnormal_vibrissa_follicle1.54973560
45MP0008058_abnormal_DNA_repair1.54740905
46MP0001853_heart_inflammation1.52612123
47MP0003436_decreased_susceptibility_to1.52157748
48MP0003632_abnormal_nervous_system1.50778755
49MP0002009_preneoplasia1.50644386
50MP0002166_altered_tumor_susceptibility1.49998100
51MP0008438_abnormal_cutaneous_collagen1.48278616
52MP0000490_abnormal_crypts_of1.46880862
53MP0003195_calcinosis1.46313572
54MP0003635_abnormal_synaptic_transmissio1.45159368
55MP0002398_abnormal_bone_marrow1.44528450
56MP0001440_abnormal_grooming_behavior1.44215387
57MP0001529_abnormal_vocalization1.43860534
58MP0000858_altered_metastatic_potential1.43567795
59MP0002064_seizures1.43238055
60MP0005423_abnormal_somatic_nervous1.40620759
61MP0005083_abnormal_biliary_tract1.39710897
62MP0004859_abnormal_synaptic_plasticity1.39344242
63MP0003221_abnormal_cardiomyocyte_apopto1.36662959
64MP0000313_abnormal_cell_death1.36246942
65MP0002090_abnormal_vision1.35072705
66MP0008260_abnormal_autophagy1.34241383
67MP0000703_abnormal_thymus_morphology1.33413952
68MP0003786_premature_aging1.32506006
69MP0005501_abnormal_skin_physiology1.31624546
70MP0003300_gastrointestinal_ulcer1.31526205
71MP0009278_abnormal_bone_marrow1.29232040
72MP0006035_abnormal_mitochondrial_morpho1.28888838
73MP0002796_impaired_skin_barrier1.28508850
74MP0004858_abnormal_nervous_system1.27382442
75MP0005621_abnormal_cell_physiology1.26874306
76MP0002019_abnormal_tumor_incidence1.26686243
77* MP0002118_abnormal_lipid_homeostasis1.25949519
78MP0005408_hypopigmentation1.25835999
79MP0002722_abnormal_immune_system1.25272221
80MP0000778_abnormal_nervous_system1.24998159
81MP0001661_extended_life_span1.24765095
82* MP0002080_prenatal_lethality1.24585305
83MP0005451_abnormal_body_composition1.23512404
84MP0000358_abnormal_cell_content/1.22522893
85MP0002006_tumorigenesis1.20540664
86MP0002060_abnormal_skin_morphology1.19849415
87MP0002429_abnormal_blood_cell1.18786946
88MP0004947_skin_inflammation1.17592756
89MP0000465_gastrointestinal_hemorrhage1.17282176
90MP0002420_abnormal_adaptive_immunity1.14334712
91MP0005000_abnormal_immune_tolerance1.13948198
92MP0006276_abnormal_autonomic_nervous1.13776084
93MP0000685_abnormal_immune_system1.13592214
94MP0001819_abnormal_immune_cell1.12646305
95MP0003950_abnormal_plasma_membrane1.12562487
96MP0003984_embryonic_growth_retardation1.12300689
97MP0002419_abnormal_innate_immunity1.11308292
98MP0001672_abnormal_embryogenesis/_devel1.10845164
99MP0005380_embryogenesis_phenotype1.10845164
100MP0000689_abnormal_spleen_morphology1.10780172
101MP0000716_abnormal_immune_system1.10291301
102MP0010307_abnormal_tumor_latency1.09981169
103MP0005384_cellular_phenotype1.09352301
104MP0005584_abnormal_enzyme/coenzyme_acti1.06873140
105MP0005397_hematopoietic_system_phenotyp1.06423252
106MP0001545_abnormal_hematopoietic_system1.06423252
107MP0002452_abnormal_antigen_presenting1.06098805
108MP0001849_ear_inflammation1.05829510
109MP0003631_nervous_system_phenotype1.04808159
110MP0000372_irregular_coat_pigmentation1.04602990
111MP0005330_cardiomyopathy1.04467364
112MP0003303_peritoneal_inflammation1.04417004
113MP0002088_abnormal_embryonic_growth/wei1.04119898
114MP0003091_abnormal_cell_migration1.03609697
115MP0003453_abnormal_keratinocyte_physiol1.02434428
116MP0002272_abnormal_nervous_system1.02393759
117MP0002229_neurodegeneration1.01526121
118MP0004885_abnormal_endolymph1.01071492
119MP0001697_abnormal_embryo_size1.00706621
120MP0000013_abnormal_adipose_tissue1.00595956
121MP0001800_abnormal_humoral_immune0.99222398
122MP0009697_abnormal_copulation0.98482969
123MP0001216_abnormal_epidermal_layer0.97526367
124MP0003172_abnormal_lysosome_physiology0.97257475
125MP0000647_abnormal_sebaceous_gland0.96052811
126MP0002723_abnormal_immune_serum0.95769139
127MP0003828_pulmonary_edema0.94894058
128MP0002063_abnormal_learning/memory/cond0.94499433
129MP0005025_abnormal_response_to0.94227811
130MP0002086_abnormal_extraembryonic_tissu0.93611465
131MP0001542_abnormal_bone_strength0.93529924
132MP0002148_abnormal_hypersensitivity_rea0.93393273
133MP0004381_abnormal_hair_follicle0.91780990
134MP0000609_abnormal_liver_physiology0.91625514
135MP0000462_abnormal_digestive_system0.91421878
136MP0001486_abnormal_startle_reflex0.89917626
137MP0009046_muscle_twitch0.89492641
138MP0002734_abnormal_mechanical_nocicepti0.89393122
139MP0009745_abnormal_behavioral_response0.89226145
140MP0001905_abnormal_dopamine_level0.88332249
141MP0003136_yellow_coat_color0.87944525
142MP0000003_abnormal_adipose_tissue0.87923905
143MP0003633_abnormal_nervous_system0.87841042
144MP0005165_increased_susceptibility_to0.87568131
145MP0003718_maternal_effect0.86169550
146MP0009931_abnormal_skin_appearance0.85572680
147MP0004742_abnormal_vestibular_system0.85184958
148MP0001756_abnormal_urination0.83887250
149MP0003868_abnormal_feces_composition0.83355455
150MP0002295_abnormal_pulmonary_circulatio0.81480810
151MP0010678_abnormal_skin_adnexa0.80825312
152MP0010630_abnormal_cardiac_muscle0.80813653
153MP0005410_abnormal_fertilization0.80169205
154MP0001873_stomach_inflammation0.80074388
155MP0003448_altered_tumor_morphology0.79476133
156MP0005257_abnormal_intraocular_pressure0.79369460
157MP0002066_abnormal_motor_capabilities/c0.78906678
158MP0004185_abnormal_adipocyte_glucose0.78560084
159MP0001915_intracranial_hemorrhage0.77535329
160MP0005386_behavior/neurological_phenoty0.76622369
161MP0004924_abnormal_behavior0.76622369
162MP0005319_abnormal_enzyme/_coenzyme0.75955485
163MP0002733_abnormal_thermal_nociception0.75891807
164MP0002909_abnormal_adrenal_gland0.75616467
165MP0003656_abnormal_erythrocyte_physiolo0.75602932
166MP0004043_abnormal_pH_regulation0.75582397
167MP0005275_abnormal_skin_tensile0.73788840
168MP0002572_abnormal_emotion/affect_behav0.73033353
169MP0001299_abnormal_eye_distance/0.72997573
170MP0004019_abnormal_vitamin_homeostasis0.72824990
171MP0001727_abnormal_embryo_implantation0.72465078
172MP0004130_abnormal_muscle_cell0.72281292
173MP0002067_abnormal_sensory_capabilities0.72279086
174MP0002184_abnormal_innervation0.72176639
175MP0000751_myopathy0.71440065
176MP0004272_abnormal_basement_membrane0.70986130
177MP0001984_abnormal_olfaction0.69689113
178MP0005636_abnormal_mineral_homeostasis0.67903766
179MP0000955_abnormal_spinal_cord0.66710189
180MP0009643_abnormal_urine_homeostasis0.66688008
181MP0009780_abnormal_chondrocyte_physiolo0.66261762
182MP0003183_abnormal_peptide_metabolism0.63323954
183MP0001177_atelectasis0.62550234
184MP0002882_abnormal_neuron_morphology0.61713118
185MP0008569_lethality_at_weaning0.54957082
186MP0002152_abnormal_brain_morphology0.54902175
187MP0006036_abnormal_mitochondrial_physio0.54739669

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.26732075
2Parakeratosis (HP:0001036)4.30943660
3Hyperlipoproteinemia (HP:0010980)4.28458210
4Cerebral inclusion bodies (HP:0100314)4.15970699
5Xanthomatosis (HP:0000991)3.82488270
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.56015450
7Hypobetalipoproteinemia (HP:0003563)3.11684899
8Supranuclear gaze palsy (HP:0000605)3.10891588
9Hyperglycinemia (HP:0002154)3.08941161
10Increased serum pyruvate (HP:0003542)3.06806861
11Abnormality of glycolysis (HP:0004366)3.06806861
12Aplasia involving bones of the upper limbs (HP:0009823)3.06616166
13Aplasia of the phalanges of the hand (HP:0009802)3.06616166
14Aplasia involving bones of the extremities (HP:0009825)3.06616166
15Ragged-red muscle fibers (HP:0003200)3.04625728
16Congenital ichthyosiform erythroderma (HP:0007431)3.03973959
17Abnormality of glycine metabolism (HP:0010895)3.02937084
18Abnormality of serine family amino acid metabolism (HP:0010894)3.02937084
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.02431515
20Vertebral compression fractures (HP:0002953)2.99255985
21Intrahepatic cholestasis (HP:0001406)2.89644254
22Amniotic constriction ring (HP:0009775)2.86902729
23Abnormality of placental membranes (HP:0011409)2.86902729
24Hypolipoproteinemia (HP:0010981)2.81942966
25Hyperacusis (HP:0010780)2.79722701
26Selective tooth agenesis (HP:0001592)2.78238766
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.75487549
28Thrombocytosis (HP:0001894)2.74338277
29Progressive muscle weakness (HP:0003323)2.67027360
30Hypoalphalipoproteinemia (HP:0003233)2.66807228
31Hyperglycinuria (HP:0003108)2.63670269
32Premature rupture of membranes (HP:0001788)2.61110757
33Megalencephaly (HP:0001355)2.60281713
34Deep venous thrombosis (HP:0002625)2.59424227
35Akinesia (HP:0002304)2.59108599
36Microvesicular hepatic steatosis (HP:0001414)2.58599440
37Recurrent viral infections (HP:0004429)2.56315471
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.53946292
39Abnormal pupillary function (HP:0007686)2.52089245
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.45147581
41Osteolytic defects of the hand bones (HP:0009699)2.45147581
42Fatigue (HP:0012378)2.44852174
43Hypokalemic alkalosis (HP:0001949)2.41930448
44Spastic paraparesis (HP:0002313)2.40923397
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40723199
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.40723199
47Autoamputation (HP:0001218)2.39270686
48Pheochromocytoma (HP:0002666)2.38204846
49Abnormality of the Achilles tendon (HP:0005109)2.33039951
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.32461760
51Cerebral hemorrhage (HP:0001342)2.29930574
52Abnormalities of placenta or umbilical cord (HP:0001194)2.29593816
53Abnormality of oral frenula (HP:0000190)2.29459250
54Neuroendocrine neoplasm (HP:0100634)2.27495765
55Ketosis (HP:0001946)2.24679442
56Trismus (HP:0000211)2.24448244
57Achilles tendon contracture (HP:0001771)2.22863975
58Abnormality of the corticospinal tract (HP:0002492)2.19957040
59Hyperammonemia (HP:0001987)2.19164387
60Insomnia (HP:0100785)2.18831031
61Ileus (HP:0002595)2.17968854
62Abnormal gallbladder physiology (HP:0012438)2.17842719
63Cholecystitis (HP:0001082)2.17842719
64Fat malabsorption (HP:0002630)2.16127414
65Paraparesis (HP:0002385)2.15026791
66Insidious onset (HP:0003587)2.14685969
67Termporal pattern (HP:0011008)2.14685969
68Rough bone trabeculation (HP:0100670)2.14269721
69Abnormality of fatty-acid metabolism (HP:0004359)2.14006780
70Multiple enchondromatosis (HP:0005701)2.13716039
71Abnormality of the thoracic spine (HP:0100711)2.12435909
72Upper motor neuron abnormality (HP:0002127)2.11081550
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09811558
74Hemiplegia (HP:0002301)2.09168944
75Progressive external ophthalmoplegia (HP:0000590)2.08988116
76Impaired platelet aggregation (HP:0003540)2.08413286
77Abnormal platelet function (HP:0011869)2.08413286
78Thoracic kyphosis (HP:0002942)2.08210899
79Cellulitis (HP:0100658)2.06967580
80Intention tremor (HP:0002080)2.06700849
81Ankyloglossia (HP:0010296)2.02965598
82Abnormality of the umbilical cord (HP:0010881)2.02316578
83Cerebral hypomyelination (HP:0006808)2.01046539
84Truncal ataxia (HP:0002078)1.99559154
85Petechiae (HP:0000967)1.98986651
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97924835
87Back pain (HP:0003418)1.97387839
88Gout (HP:0001997)1.96681112
89Clumsiness (HP:0002312)1.95612945
90Distal lower limb amyotrophy (HP:0008944)1.94787783
91Steatorrhea (HP:0002570)1.94290212
92Abnormality of glycolipid metabolism (HP:0010969)1.91939795
93Abnormality of liposaccharide metabolism (HP:0010968)1.91939795
94Abnormality of glycosphingolipid metabolism (HP:0004343)1.91939795
95Short nail (HP:0001799)1.91909572
96Cerebral edema (HP:0002181)1.89213637
97Hepatosplenomegaly (HP:0001433)1.88351312
98Increased connective tissue (HP:0009025)1.87996938
99Polyphagia (HP:0002591)1.87711605
100Brushfield spots (HP:0001088)1.86971968
101Syringomyelia (HP:0003396)1.86115249
102Spinal cord lesions (HP:0100561)1.86115249
103Distal lower limb muscle weakness (HP:0009053)1.86069476
104Athetosis (HP:0002305)1.85941888
105Orthostatic hypotension (HP:0001278)1.84842202
106Increased neuronal autofluorescent lipopigment (HP:0002074)1.84727044
107Deviation of the thumb (HP:0009603)1.82683579
108Spastic gait (HP:0002064)1.82292763
109Ketoacidosis (HP:0001993)1.81109464
110Hyperphosphaturia (HP:0003109)1.79312586
111Flat acetabular roof (HP:0003180)1.79263169
112Irritability (HP:0000737)1.79192013
113Delusions (HP:0000746)1.78976540
114Mutism (HP:0002300)1.78973472
115Peripheral hypomyelination (HP:0007182)1.78907678
116Abnormality of serum amino acid levels (HP:0003112)1.78492711
117Increased cerebral lipofuscin (HP:0011813)1.77367469
118Lethargy (HP:0001254)1.77361113
119Postnatal microcephaly (HP:0005484)1.77182773
120Colitis (HP:0002583)1.76979120
121Granulocytopenia (HP:0001913)1.75830724
122Abnormality of the distal phalanges of the toes (HP:0010182)1.75226966
123Ankle clonus (HP:0011448)1.75043135
124Generalized myoclonic seizures (HP:0002123)1.74974049
125IgA deficiency (HP:0002720)1.74281719
126Brittle hair (HP:0002299)1.73490256
127Loss of speech (HP:0002371)1.73320580
128Gastrointestinal inflammation (HP:0004386)1.72904961
129Hemiparesis (HP:0001269)1.71939020
130Reticulocytosis (HP:0001923)1.71655857
131Agammaglobulinemia (HP:0004432)1.70509375
132Reduced subcutaneous adipose tissue (HP:0003758)1.70353240
133Restlessness (HP:0000711)1.70000507
134Poor suck (HP:0002033)1.69879404
135Testicular atrophy (HP:0000029)1.69839980
136CNS demyelination (HP:0007305)1.69816215
137Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69735998
138Diminished movement (HP:0002374)1.69575807
139Nonimmune hydrops fetalis (HP:0001790)1.69109830
140Sensory axonal neuropathy (HP:0003390)1.68997757
141Increased serum ferritin (HP:0003281)1.68980178
142Delayed CNS myelination (HP:0002188)1.68723378
143Dysostosis multiplex (HP:0000943)1.68065254
144B lymphocytopenia (HP:0010976)1.67534092
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67469116
146Dialeptic seizures (HP:0011146)1.66873019
147Abnormality of methionine metabolism (HP:0010901)1.65968211
148Abnormality of reticulocytes (HP:0004312)1.65142536
149Abnormal eating behavior (HP:0100738)1.64832965
150Ridged nail (HP:0001807)1.64588276
151Neuronal loss in central nervous system (HP:0002529)1.64284504
152Abnormality of cells of the erythroid lineage (HP:0012130)1.64261176
153Chromsome breakage (HP:0040012)1.63546874
154Methylmalonic aciduria (HP:0012120)1.62700036
155Proximal placement of thumb (HP:0009623)1.62190714
156Epiphyseal stippling (HP:0010655)1.61311744
157Aplastic anemia (HP:0001915)1.61216489
158Hypoplastic left heart (HP:0004383)1.61058355
159Onion bulb formation (HP:0003383)1.60597479
160Alkalosis (HP:0001948)1.60336941
161Reduced antithrombin III activity (HP:0001976)1.60060462
162Abnormality of carpal bone ossification (HP:0006257)1.59284767
163Complement deficiency (HP:0004431)1.58709667
164Patellar dislocation (HP:0002999)1.58142847
165Progressive hearing impairment (HP:0001730)1.58112535
166Recurrent abscess formation (HP:0002722)1.58065333
167Pelvic girdle muscle weakness (HP:0003749)1.57518009
168Autoimmune hemolytic anemia (HP:0001890)1.57094584
169Abnormality of the tricuspid valve (HP:0001702)1.56312534
170Entropion (HP:0000621)1.55031521
171Viral hepatitis (HP:0006562)1.54900012
172Asymmetry of the thorax (HP:0001555)1.54170401
173Microretrognathia (HP:0000308)1.53193615
174Generalized amyotrophy (HP:0003700)1.52863250
175Abnormal trabecular bone morphology (HP:0100671)1.51987663
176Onycholysis (HP:0001806)1.51778867
177Long palpebral fissure (HP:0000637)1.51569025
178Reticulocytopenia (HP:0001896)1.51392190
179Aplasia/Hypoplasia of the thymus (HP:0010515)1.51365517
180Ankle contracture (HP:0006466)1.50386239
181Hypergonadotropic hypogonadism (HP:0000815)1.50176070
182Abnormality of macrophages (HP:0004311)1.50130872
183Squamous cell carcinoma (HP:0002860)1.49566032
184Broad face (HP:0000283)1.48987214
185Hypokinesia (HP:0002375)1.48481535
186Abnormality of T cell physiology (HP:0011840)1.48245645
187Combined immunodeficiency (HP:0005387)1.48234805
188Acute lymphatic leukemia (HP:0006721)1.47927725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.21077857
2STK393.85163462
3IRAK33.22309074
4MARK12.85743927
5ARAF2.58575155
6PRPF4B2.51262553
7LIMK12.46579290
8MUSK2.46577737
9OXSR12.46178675
10SMG12.43727729
11CDK122.37307078
12EEF2K2.27062916
13ERN12.26053362
14TESK22.16044188
15BCR2.15042703
16BCKDK1.92475620
17MAP3K91.88467183
18NTRK11.87660730
19MET1.87265762
20LMTK21.83792294
21FGFR21.79492720
22TTN1.78474204
23ICK1.77068664
24PAK61.76011949
25WNK41.73544428
26FER1.73233405
27PAK31.71179860
28EPHA41.70972603
29MST41.70521513
30NEK11.67400169
31EPHB11.66606952
32MAP3K111.58147347
33PHKG11.57015145
34PHKG21.57015145
35SCYL21.56605158
36KSR21.53130267
37ACVR1B1.52470808
38MAP2K31.51342302
39CDC71.48407271
40SRPK11.46409110
41NTRK21.37200950
42MAP3K141.37065205
43CDK81.32894713
44MAP4K11.26816405
45PBK1.26772240
46CSNK1G31.25830641
47MINK11.25545768
48DYRK21.22308946
49RPS6KB21.22281919
50MAP3K21.22236412
51PAK41.20912109
52MAP3K101.19508943
53MAP3K81.19142953
54RPS6KA41.18394702
55CDK41.17906987
56CDK61.16518124
57CSNK1G21.16030210
58TTK1.15976252
59TYRO31.14976519
60CDK141.14704400
61ROCK21.12794952
62EPHA21.12413350
63CDK191.08789405
64MST1R1.07883470
65KSR11.07535633
66CDK71.07291612
67EIF2AK11.07146556
68RIPK41.05223321
69MAP3K131.04448752
70CSNK1G11.03329563
71PKN21.02657125
72MAP3K31.01040699
73PDK31.00930986
74PDK41.00930986
75FGR0.99101401
76NME10.96858470
77MAP3K120.96633338
78CAMK2G0.94599423
79MAPK110.93937532
80CDK150.93614806
81KDR0.93479187
82MAP2K40.92836742
83CAMK2B0.91142218
84CDK180.90585838
85BUB10.89792316
86CLK10.89140578
87ERBB40.89099915
88SIK10.88349176
89MAP2K10.88304276
90FLT30.87333924
91RAF10.85035978
92TRIB30.83969493
93UHMK10.82764703
94CSNK1A1L0.82757491
95TESK10.82675257
96CDK11A0.82533941
97CDK50.81999836
98STK100.81908964
99LRRK20.81366765
100VRK20.77536585
101CAMKK20.77209868
102CSF1R0.77184092
103ROCK10.75867991
104ILK0.75222170
105CHEK20.74484938
106PRKCG0.73652534
107JAK30.73497259
108MAP3K40.72096030
109PAK10.71752322
110STK40.71480842
111AURKB0.71335954
112PRKD30.70900628
113ATR0.70627861
114AURKA0.70060071
115ZAP700.69996770
116ABL20.68504784
117TBK10.68297792
118BRAF0.67860286
119PKN10.67768290
120PNCK0.66957768
121MTOR0.66937614
122MAPKAPK50.65769793
123MAP2K20.65545258
124FGFR40.65225628
125CAMK2D0.64838997
126PIM20.63539339
127GRK60.62170399
128KIT0.62066082
129IRAK20.61688366
130NEK60.61594151
131WNK10.61446318
132DAPK10.60422048
133CAMK2A0.59945312
134PRKCE0.59167656
135CAMKK10.58472216
136PDK20.57888442
137FYN0.55900275
138TSSK60.55802170
139PDPK10.55762005
140PAK20.55417016
141IRAK40.55150027
142BTK0.54909633
143CHEK10.53962466
144EIF2AK30.52895162
145BMPR20.52722992
146MAP3K50.52534175
147MAPK130.51355373
148PRKCQ0.51178637
149TAOK20.51033221
150MAP3K60.50856714
151NEK20.50344464
152PDGFRA0.49874504
153STK160.49850352
154MAP3K10.48882912
155CCNB10.48581671
156PTK20.47959543
157PASK0.47942191
158PTK60.47197985
159FGFR10.45995118
160EPHA30.45148444
161MOS0.44334475
162TYK20.44047174
163MAPK120.42920647
164BMPR1B0.42830847
165ALK0.39650388
166FES0.39208468
167ITK0.37690734
168PLK40.37563919
169RPS6KC10.35261429
170RPS6KL10.35261429
171CDK20.34921460
172SYK0.34117523
173PIM10.33911383

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.13179509
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.23822448
3Steroid biosynthesis_Homo sapiens_hsa001003.05364607
4Nitrogen metabolism_Homo sapiens_hsa009102.96269229
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.79713631
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77059777
7Fatty acid elongation_Homo sapiens_hsa000622.59167132
8Base excision repair_Homo sapiens_hsa034102.53702515
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52933757
10Sulfur metabolism_Homo sapiens_hsa009202.36258291
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30419540
12Butanoate metabolism_Homo sapiens_hsa006502.30053688
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26829241
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26682790
15Fatty acid degradation_Homo sapiens_hsa000712.25266886
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24697847
17Mismatch repair_Homo sapiens_hsa034302.19723205
18Other glycan degradation_Homo sapiens_hsa005112.17323398
19Sulfur relay system_Homo sapiens_hsa041222.15963970
20Vitamin B6 metabolism_Homo sapiens_hsa007502.08857277
21Fatty acid metabolism_Homo sapiens_hsa012122.07568955
22Ribosome_Homo sapiens_hsa030102.05820136
23Propanoate metabolism_Homo sapiens_hsa006401.99362460
24Non-homologous end-joining_Homo sapiens_hsa034501.96108138
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.92982625
26Spliceosome_Homo sapiens_hsa030401.92312806
27Cell cycle_Homo sapiens_hsa041101.86925890
28Nucleotide excision repair_Homo sapiens_hsa034201.76480552
29RNA transport_Homo sapiens_hsa030131.74007883
30Histidine metabolism_Homo sapiens_hsa003401.73628284
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.69760650
32Acute myeloid leukemia_Homo sapiens_hsa052211.69462170
33Pyrimidine metabolism_Homo sapiens_hsa002401.68246185
34Chronic myeloid leukemia_Homo sapiens_hsa052201.52189287
35PPAR signaling pathway_Homo sapiens_hsa033201.51658119
36Fat digestion and absorption_Homo sapiens_hsa049751.48586550
37Folate biosynthesis_Homo sapiens_hsa007901.47465609
38Tryptophan metabolism_Homo sapiens_hsa003801.47381316
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46343367
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45114265
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.42801854
42Bladder cancer_Homo sapiens_hsa052191.39211676
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38967463
44Oxidative phosphorylation_Homo sapiens_hsa001901.36608484
45Arginine biosynthesis_Homo sapiens_hsa002201.35632414
46Shigellosis_Homo sapiens_hsa051311.34128155
47Pancreatic cancer_Homo sapiens_hsa052121.34039767
48Peroxisome_Homo sapiens_hsa041461.31281602
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30970783
50Non-small cell lung cancer_Homo sapiens_hsa052231.28529357
51Carbon metabolism_Homo sapiens_hsa012001.28266374
52Proteasome_Homo sapiens_hsa030501.27003917
53One carbon pool by folate_Homo sapiens_hsa006701.26775171
54Viral carcinogenesis_Homo sapiens_hsa052031.26487795
55Ether lipid metabolism_Homo sapiens_hsa005651.26412480
56beta-Alanine metabolism_Homo sapiens_hsa004101.25096083
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.25032207
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24989251
59Fructose and mannose metabolism_Homo sapiens_hsa000511.24593042
60B cell receptor signaling pathway_Homo sapiens_hsa046621.20736973
61Pyruvate metabolism_Homo sapiens_hsa006201.20407436
62Small cell lung cancer_Homo sapiens_hsa052221.17675855
63Vitamin digestion and absorption_Homo sapiens_hsa049771.13852424
64Thyroid cancer_Homo sapiens_hsa052161.13383379
65Arginine and proline metabolism_Homo sapiens_hsa003301.12480561
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11107108
67Sphingolipid metabolism_Homo sapiens_hsa006001.10472316
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08879477
69Homologous recombination_Homo sapiens_hsa034401.06183782
70Epstein-Barr virus infection_Homo sapiens_hsa051691.04476127
71Lysosome_Homo sapiens_hsa041421.03644725
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03563646
73Apoptosis_Homo sapiens_hsa042101.03463106
74mRNA surveillance pathway_Homo sapiens_hsa030151.03377312
75Primary immunodeficiency_Homo sapiens_hsa053401.03180848
76Bile secretion_Homo sapiens_hsa049761.02851297
77Parkinsons disease_Homo sapiens_hsa050121.01049341
78Glycerolipid metabolism_Homo sapiens_hsa005611.00049544
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.99964839
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99893954
81* Glycerophospholipid metabolism_Homo sapiens_hsa005640.97516138
82Galactose metabolism_Homo sapiens_hsa000520.97215344
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96309261
84Biosynthesis of amino acids_Homo sapiens_hsa012300.95220360
85Herpes simplex infection_Homo sapiens_hsa051680.94780297
86Hepatitis B_Homo sapiens_hsa051610.94073792
87Regulation of autophagy_Homo sapiens_hsa041400.93356358
88Systemic lupus erythematosus_Homo sapiens_hsa053220.93223612
89Glutathione metabolism_Homo sapiens_hsa004800.92759588
90Complement and coagulation cascades_Homo sapiens_hsa046100.89867440
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89400588
92Caffeine metabolism_Homo sapiens_hsa002320.87802564
93Retinol metabolism_Homo sapiens_hsa008300.86979024
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.86064706
95Antigen processing and presentation_Homo sapiens_hsa046120.85728200
96Pentose phosphate pathway_Homo sapiens_hsa000300.84833466
97RNA polymerase_Homo sapiens_hsa030200.84353569
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.83833004
99GABAergic synapse_Homo sapiens_hsa047270.81071389
100Alzheimers disease_Homo sapiens_hsa050100.80527110
101HTLV-I infection_Homo sapiens_hsa051660.79867923
102Protein export_Homo sapiens_hsa030600.79739780
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79664872
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79652066
105Mineral absorption_Homo sapiens_hsa049780.79641687
106Fatty acid biosynthesis_Homo sapiens_hsa000610.79488100
107Viral myocarditis_Homo sapiens_hsa054160.77181843
108Measles_Homo sapiens_hsa051620.74465442
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73116015
110Vibrio cholerae infection_Homo sapiens_hsa051100.70406450
111Leishmaniasis_Homo sapiens_hsa051400.69891363
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69890754
113VEGF signaling pathway_Homo sapiens_hsa043700.69485912
114Toxoplasmosis_Homo sapiens_hsa051450.69318435
115Influenza A_Homo sapiens_hsa051640.68965036
116* Metabolic pathways_Homo sapiens_hsa011000.68575722
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67952940
118Chemical carcinogenesis_Homo sapiens_hsa052040.64691519
119Purine metabolism_Homo sapiens_hsa002300.63821481
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63623471
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63534928
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62732313
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61837036
124Synaptic vesicle cycle_Homo sapiens_hsa047210.61755810
125p53 signaling pathway_Homo sapiens_hsa041150.61706011
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.61276873
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60318266
128Linoleic acid metabolism_Homo sapiens_hsa005910.59827388
129Salmonella infection_Homo sapiens_hsa051320.59717006
130Collecting duct acid secretion_Homo sapiens_hsa049660.59180309
131Renin-angiotensin system_Homo sapiens_hsa046140.59152943
132Prion diseases_Homo sapiens_hsa050200.59039788
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58653429
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58570831
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.57422080
136Phenylalanine metabolism_Homo sapiens_hsa003600.57218942
137Legionellosis_Homo sapiens_hsa051340.54783804
138Colorectal cancer_Homo sapiens_hsa052100.53111492
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52950714
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52783609
141Tyrosine metabolism_Homo sapiens_hsa003500.52580852
142mTOR signaling pathway_Homo sapiens_hsa041500.51818157
143Axon guidance_Homo sapiens_hsa043600.51423480
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51391451
145Osteoclast differentiation_Homo sapiens_hsa043800.50998277
146Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49838663
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49201128
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49046970
149MicroRNAs in cancer_Homo sapiens_hsa052060.47867423
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47556453
151Fanconi anemia pathway_Homo sapiens_hsa034600.46689289
152N-Glycan biosynthesis_Homo sapiens_hsa005100.46603603
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46043155
154Neurotrophin signaling pathway_Homo sapiens_hsa047220.45375036
155Glioma_Homo sapiens_hsa052140.45319934
156Cardiac muscle contraction_Homo sapiens_hsa042600.45018260
157Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44056164
158Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43777173
159Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42336160
160Pancreatic secretion_Homo sapiens_hsa049720.41410079
161Hematopoietic cell lineage_Homo sapiens_hsa046400.41240005
162T cell receptor signaling pathway_Homo sapiens_hsa046600.41047609
163Nicotine addiction_Homo sapiens_hsa050330.39709238
164TNF signaling pathway_Homo sapiens_hsa046680.39218448
165Renal cell carcinoma_Homo sapiens_hsa052110.39118495
166Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38963050
167Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38616481
168HIF-1 signaling pathway_Homo sapiens_hsa040660.38376054
169Proteoglycans in cancer_Homo sapiens_hsa052050.38348852
170Tuberculosis_Homo sapiens_hsa051520.38030003
171Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37708328
172Prostate cancer_Homo sapiens_hsa052150.36102488
173Sphingolipid signaling pathway_Homo sapiens_hsa040710.35839279
174Endocytosis_Homo sapiens_hsa041440.35754864
175Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30356596
176Selenocompound metabolism_Homo sapiens_hsa004500.27355901
177Huntingtons disease_Homo sapiens_hsa050160.26177723
178Long-term depression_Homo sapiens_hsa047300.25896639
179Staphylococcus aureus infection_Homo sapiens_hsa051500.23219779

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