PTDSS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine, a structural membrane phospholipid that functions in cell signaling, blood coagulation, and apoptosis. The encoded enzyme also has a high affinity for docosahexaenoic acid (DHA) and can use it to make DHA-containing phosphatidylserine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin transmembrane transport (GO:0035461)6.75587832
2purine nucleobase biosynthetic process (GO:0009113)6.68630871
3nucleobase biosynthetic process (GO:0046112)5.88257290
4mitotic metaphase plate congression (GO:0007080)5.15424168
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.14004967
6peptidyl-arginine omega-N-methylation (GO:0035247)4.87483326
7GMP metabolic process (GO:0046037)4.81495776
8ribosome assembly (GO:0042255)4.71921204
9regulation of spindle organization (GO:0090224)4.65490657
10DNA replication checkpoint (GO:0000076)4.53329837
11regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.47543602
12ribosome biogenesis (GO:0042254)4.42504270
13regulation of early endosome to late endosome transport (GO:2000641)4.41188223
14folic acid metabolic process (GO:0046655)4.32817093
15lung-associated mesenchyme development (GO:0060484)4.26623773
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.16574805
17termination of RNA polymerase III transcription (GO:0006386)4.16574805
18positive regulation of chromosome segregation (GO:0051984)4.15880361
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.15011079
20planar cell polarity pathway involved in neural tube closure (GO:0090179)4.10765145
21pantothenate metabolic process (GO:0015939)3.99372522
22metaphase plate congression (GO:0051310)3.99197613
23ribosomal small subunit biogenesis (GO:0042274)3.96844040
24protein retention in ER lumen (GO:0006621)3.91002715
25peptidyl-arginine N-methylation (GO:0035246)3.90504344
26peptidyl-arginine methylation (GO:0018216)3.90504344
27DNA replication initiation (GO:0006270)3.89994923
28guanosine-containing compound biosynthetic process (GO:1901070)3.86032254
29blastocyst development (GO:0001824)3.83356991
30proline biosynthetic process (GO:0006561)3.80110884
31microtubule depolymerization (GO:0007019)3.78275419
32regulation of translational fidelity (GO:0006450)3.77438988
33regulation of mitotic spindle organization (GO:0060236)3.76832177
34regulation of chromosome segregation (GO:0051983)3.75956985
35spliceosomal snRNP assembly (GO:0000387)3.72683011
36heterochromatin organization (GO:0070828)3.70920555
37regulation of mammary gland epithelial cell proliferation (GO:0033599)3.68446576
38negative regulation of chromosome segregation (GO:0051985)3.66913196
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.66151511
40mitotic nuclear envelope disassembly (GO:0007077)3.63744614
41spindle checkpoint (GO:0031577)3.63544173
42mitotic spindle checkpoint (GO:0071174)3.62153083
43apoptotic process involved in morphogenesis (GO:0060561)3.59140506
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.58532685
45negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.58086047
46negative regulation of sister chromatid segregation (GO:0033046)3.58086047
47negative regulation of mitotic sister chromatid separation (GO:2000816)3.58086047
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.58086047
49mitotic sister chromatid segregation (GO:0000070)3.55979943
50synaptonemal complex assembly (GO:0007130)3.55579116
51rRNA modification (GO:0000154)3.55041979
52CDP-diacylglycerol metabolic process (GO:0046341)3.54646697
53regulation of G0 to G1 transition (GO:0070316)3.52944153
54mitotic spindle assembly checkpoint (GO:0007094)3.49217449
55protein localization to chromosome, centromeric region (GO:0071459)3.46957752
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.46464601
57nuclear pore organization (GO:0006999)3.42406175
58protein localization to kinetochore (GO:0034501)3.41996556
59spindle assembly checkpoint (GO:0071173)3.41205428
60membrane disassembly (GO:0030397)3.40444966
61nuclear envelope disassembly (GO:0051081)3.40444966
62convergent extension (GO:0060026)3.39661689
63DNA deamination (GO:0045006)3.38936180
64folic acid transport (GO:0015884)3.37954535
65adherens junction assembly (GO:0034333)3.37448578
66semaphorin-plexin signaling pathway (GO:0071526)3.36743061
67axonemal dynein complex assembly (GO:0070286)3.35892221
68meiosis I (GO:0007127)3.35690878
69regulation of centrosome cycle (GO:0046605)3.34733367
70regulation of mitotic metaphase/anaphase transition (GO:0030071)3.33392567
71synaptonemal complex organization (GO:0070193)3.33205310
72regulation of exit from mitosis (GO:0007096)3.29692602
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28766339
74DNA replication-dependent nucleosome organization (GO:0034723)3.26589753
75DNA replication-dependent nucleosome assembly (GO:0006335)3.26589753
76protein maturation by protein folding (GO:0022417)3.26448486
777-methylguanosine mRNA capping (GO:0006370)3.25587138
78transcription elongation from RNA polymerase I promoter (GO:0006362)3.25506102
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24973574
80viral transcription (GO:0019083)3.22578637
81transcription from RNA polymerase I promoter (GO:0006360)3.22133230
82COPI coating of Golgi vesicle (GO:0048205)3.21422514
83Golgi transport vesicle coating (GO:0048200)3.21422514
84biotin metabolic process (GO:0006768)3.21074418
85proteasome assembly (GO:0043248)3.19695804
86termination of RNA polymerase I transcription (GO:0006363)3.19339521
87paraxial mesoderm development (GO:0048339)3.18944097
88basement membrane organization (GO:0071711)3.17544311
89modified amino acid transport (GO:0072337)3.17534257
90DNA strand elongation involved in DNA replication (GO:0006271)3.15333547
917-methylguanosine RNA capping (GO:0009452)3.15046199
92RNA capping (GO:0036260)3.15046199
93regulation of sister chromatid segregation (GO:0033045)3.14770381
94regulation of mitotic sister chromatid separation (GO:0010965)3.14770381
95regulation of mitotic sister chromatid segregation (GO:0033047)3.14770381
96cell-cell junction maintenance (GO:0045217)3.13813736
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.13451021
98focal adhesion assembly (GO:0048041)3.12265066
99cell-substrate adherens junction assembly (GO:0007045)3.12265066
100nuclear pore complex assembly (GO:0051292)3.10680362
101autophagic vacuole assembly (GO:0000045)3.10015007
102establishment of chromosome localization (GO:0051303)3.09414455
103regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09084357
104maturation of 5.8S rRNA (GO:0000460)3.08928767
105cilium or flagellum-dependent cell motility (GO:0001539)3.07475083
106proline metabolic process (GO:0006560)3.07328094
107ribonucleoprotein complex biogenesis (GO:0022613)3.06780361
108negative regulation of proteasomal protein catabolic process (GO:1901799)3.03510076
109negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.03284135
110cytoskeletal anchoring at plasma membrane (GO:0007016)3.02296451
111DNA strand elongation (GO:0022616)3.02080709
112bone trabecula formation (GO:0060346)3.00369624
113rRNA processing (GO:0006364)3.00309470
114formation of translation preinitiation complex (GO:0001731)3.00210532
115positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99547704
116cell-substrate junction assembly (GO:0007044)2.98698962
117nuclear envelope organization (GO:0006998)2.98416418
118mannose metabolic process (GO:0006013)2.98398827
119male meiosis I (GO:0007141)2.97926653
120rRNA metabolic process (GO:0016072)2.94691743
121transcription initiation from RNA polymerase I promoter (GO:0006361)2.94110381
122histone exchange (GO:0043486)2.94106117
123CDP-diacylglycerol biosynthetic process (GO:0016024)2.93661828
124establishment of apical/basal cell polarity (GO:0035089)2.92962296
125DNA-templated transcription, elongation (GO:0006354)2.91096971
126hemidesmosome assembly (GO:0031581)2.91002304
127histone-serine phosphorylation (GO:0035404)2.90941713
128rRNA methylation (GO:0031167)2.89388760
129epithelial cell-cell adhesion (GO:0090136)2.89031174
130translational termination (GO:0006415)2.88965572
131negative regulation of mitosis (GO:0045839)2.88900918
132histone arginine methylation (GO:0034969)2.87007873
133protein K6-linked ubiquitination (GO:0085020)2.84990739
134transcription elongation from RNA polymerase II promoter (GO:0006368)2.84281495
135negative regulation of cell size (GO:0045792)2.83121514
136S-adenosylmethionine metabolic process (GO:0046500)2.82869353
137regulation of spindle checkpoint (GO:0090231)2.82462258
138negative regulation of catenin import into nucleus (GO:0035414)2.81444666
139retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81399239
140tooth mineralization (GO:0034505)2.80323554
141cochlea morphogenesis (GO:0090103)2.75956605
142protein localization to endosome (GO:0036010)2.74687095
143maturation of SSU-rRNA (GO:0030490)2.73796610
144glucose 6-phosphate metabolic process (GO:0051156)2.73624299
145nucleosome disassembly (GO:0006337)2.70293405
146protein-DNA complex disassembly (GO:0032986)2.70293405
147DNA unwinding involved in DNA replication (GO:0006268)2.67461888
148embryonic viscerocranium morphogenesis (GO:0048703)2.66258956
149positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.62420040
150UV protection (GO:0009650)2.60284071
151peptidyl-proline hydroxylation (GO:0019511)2.59027788
152apoptotic process involved in development (GO:1902742)2.58821466
153nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.57977738
154atrioventricular valve morphogenesis (GO:0003181)2.57295648
155synaptic vesicle docking involved in exocytosis (GO:0016081)2.56400356
1564-hydroxyproline metabolic process (GO:0019471)2.56035402
157translational elongation (GO:0006414)2.55636197
158glucose catabolic process (GO:0006007)2.55094468
159establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.53542055
160mitochondrion transport along microtubule (GO:0047497)2.53542055
161neural tube development (GO:0021915)2.50985232
162intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.49552482
163Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.49330474
164stress fiber assembly (GO:0043149)2.49022401
165protein insertion into membrane (GO:0051205)2.47528504
166pattern specification involved in kidney development (GO:0061004)2.46802347
167protein complex disassembly (GO:0043241)2.46518468
168activation of Rac GTPase activity (GO:0032863)2.45528966
169mitochondrial fusion (GO:0008053)2.44953266
170cellular protein complex disassembly (GO:0043624)2.43902365
171pentose-phosphate shunt (GO:0006098)2.43689415
172urogenital system development (GO:0001655)2.42701090
173viral life cycle (GO:0019058)2.41482585
174establishment or maintenance of monopolar cell polarity (GO:0061339)2.41303360
175establishment of monopolar cell polarity (GO:0061162)2.41303360
176regulation of glucose import in response to insulin stimulus (GO:2001273)2.40117357
177regulation of cholesterol biosynthetic process (GO:0045540)2.40030379
178camera-type eye morphogenesis (GO:0048593)2.39459440
179protein complex localization (GO:0031503)2.39267843
180protein targeting to plasma membrane (GO:0072661)2.36612723
181L-serine metabolic process (GO:0006563)2.36260105
182sodium ion export (GO:0071436)2.36225006
183maternal placenta development (GO:0001893)2.34654359
184mitotic chromosome condensation (GO:0007076)2.32056229
185vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.31851072
186cell migration in hindbrain (GO:0021535)2.31151861
187mitotic G1 DNA damage checkpoint (GO:0031571)2.30343317
188regulation of establishment of planar polarity (GO:0090175)2.29193247
189ncRNA 3-end processing (GO:0043628)2.29040262
190vagina development (GO:0060068)2.28543796
191pentose metabolic process (GO:0019321)2.27921511
192muscle cell fate commitment (GO:0042693)2.27521373
193intracellular estrogen receptor signaling pathway (GO:0030520)2.27192803
194activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.26417962
195receptor recycling (GO:0001881)2.26243544
196negative regulation of erythrocyte differentiation (GO:0045647)2.24786190
197mesoderm formation (GO:0001707)2.24354493
198establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.23226924
199macromolecular complex disassembly (GO:0032984)2.22589528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.08682730
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.49579160
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.43015561
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.64075328
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.60806901
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.44773948
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36264449
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30459124
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20728779
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.11355184
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09211458
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.97708914
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84764511
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82552137
15* LXR_22292898_ChIP-Seq_THP-1_Human2.81417936
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80891620
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64719809
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62622360
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.56776524
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53837853
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50238091
22AR_21909140_ChIP-Seq_LNCAP_Human2.45329025
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.44798208
24* ELK3_25401928_ChIP-Seq_HUVEC_Human2.32072459
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28327678
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26376460
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24725728
28XRN2_22483619_ChIP-Seq_HELA_Human2.24491583
29VDR_21846776_ChIP-Seq_THP-1_Human2.24443744
30NANOG_18555785_ChIP-Seq_MESCs_Mouse2.17505527
31ERG_21242973_ChIP-ChIP_JURKAT_Human2.04678395
32* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01576786
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99962104
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99116241
35* MYC_22102868_ChIP-Seq_BL_Human1.97124313
36GABP_19822575_ChIP-Seq_HepG2_Human1.96636481
37* RACK7_27058665_Chip-Seq_MCF-7_Human1.95705975
38KDM2B_26808549_Chip-Seq_K562_Human1.92988391
39VDR_23849224_ChIP-Seq_CD4+_Human1.90107763
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88379804
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88146345
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87644053
43* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84794870
44* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83952671
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81813089
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80704305
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.80037357
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79166317
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78480413
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76282761
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72455981
52* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.70355415
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68792824
54ZNF263_19887448_ChIP-Seq_K562_Human1.67726350
55KDM2B_26808549_Chip-Seq_DND41_Human1.67524705
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66474022
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.61463676
58DCP1A_22483619_ChIP-Seq_HELA_Human1.58603646
59TTF2_22483619_ChIP-Seq_HELA_Human1.58029307
60* FOXP3_21729870_ChIP-Seq_TREG_Human1.56725494
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55486696
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55149049
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.53673634
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52852259
65* SA1_27219007_Chip-Seq_ERYTHROID_Human1.52717321
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51745442
67KDM5A_27292631_Chip-Seq_BREAST_Human1.48369946
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47943743
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47729587
70* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45976294
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45839402
72* CTCF_27219007_Chip-Seq_Bcells_Human1.44418733
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43582505
74SMC4_20622854_ChIP-Seq_HELA_Human1.42497523
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42371388
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41834071
77TCF7_22412390_ChIP-Seq_EML_Mouse1.38436735
78TP53_22127205_ChIP-Seq_IMR90_Human1.37242625
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36651895
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35724428
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35000731
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34788759
83* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34725139
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31133765
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30516017
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.30254208
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30213090
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.27758852
89* CREB1_26743006_Chip-Seq_LNCaP_Human1.27663303
90* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25231693
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24599258
92* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24404604
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24250859
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24096741
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.23161591
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22886831
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.22826702
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22442564
99* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22416753
100* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21294092
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.20471595
102SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20144173
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19916830
104* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19659850
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19380197
106ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19353865
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18671241
108* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17165489
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16541031
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16435840
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16307152
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13272015
113SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12976018
114RARA_24833708_ChIP-Seq_LIVER_Mouse1.12928671
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12795230
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11547737
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10993466
118POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.10331179
119* TET1_21490601_ChIP-Seq_MESCs_Mouse1.10203696
120CIITA_25753668_ChIP-Seq_RAJI_Human1.09856999
121* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08653137
122* ATF3_27146783_Chip-Seq_COLON_Human1.08253310
123* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07747915
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07078684
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07058910
126* NCOR1_26117541_ChIP-Seq_K562_Human1.06683047
127* CLOCK_20551151_ChIP-Seq_293T_Human1.04867104
128* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04224700
129ESR2_21235772_ChIP-Seq_MCF-7_Human1.03936717
130TP53_20018659_ChIP-ChIP_R1E_Mouse1.03189690
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02089272
132* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01829361
133PHF8_20622854_ChIP-Seq_HELA_Human1.01772076
134* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01036939
135TP63_19390658_ChIP-ChIP_HaCaT_Human1.00668203
136* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00591272
137NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00363551
138* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00198801
139CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99360866
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99294471
141* CTCF_21964334_Chip-Seq_Bcells_Human0.99108875
142FOXP1_21924763_ChIP-Seq_HESCs_Human0.98743478
143KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98634412
144GATA1_26923725_Chip-Seq_HPCs_Mouse0.97591912
145KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97122836
146SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96840966
147OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96256294
148SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94815105
149CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93356847
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.90409730
151E2F1_20622854_ChIP-Seq_HELA_Human0.89474359
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89158175
153NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88586816
154KAP1_27257070_Chip-Seq_ESCs_Mouse0.88165279
155OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87581352
156* P68_20966046_ChIP-Seq_HELA_Human0.87218030
157PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85842992
158TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85540987
159* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85225338
160EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84063441
161SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82290774
162BCOR_27268052_Chip-Seq_Bcells_Human0.82005556
163SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78130436
164SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75878026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.51751929
2MP0003111_abnormal_nucleus_morphology4.74408683
3MP0003705_abnormal_hypodermis_morpholog4.09601785
4MP0003718_maternal_effect3.81874848
5MP0010094_abnormal_chromosome_stability3.61438949
6MP0004957_abnormal_blastocyst_morpholog3.50687629
7MP0005377_hearing/vestibular/ear_phenot3.41665166
8MP0003878_abnormal_ear_physiology3.41665166
9MP0005257_abnormal_intraocular_pressure3.40552807
10MP0003077_abnormal_cell_cycle3.12986888
11MP0002653_abnormal_ependyma_morphology2.98631038
12MP0005410_abnormal_fertilization2.78609454
13MP0005058_abnormal_lysosome_morphology2.74279285
14MP0008058_abnormal_DNA_repair2.69676490
15MP0003656_abnormal_erythrocyte_physiolo2.68377437
16MP0008260_abnormal_autophagy2.67596188
17MP0008438_abnormal_cutaneous_collagen2.67403669
18MP0004858_abnormal_nervous_system2.65735682
19MP0000566_synostosis2.50419685
20MP0001849_ear_inflammation2.44882812
21MP0003786_premature_aging2.38597550
22MP0003123_paternal_imprinting2.33176981
23MP0008057_abnormal_DNA_replication2.33063607
24MP0008877_abnormal_DNA_methylation2.30220889
25MP0005409_darkened_coat_color2.29635418
26MP0004272_abnormal_basement_membrane2.29217526
27MP0004233_abnormal_muscle_weight2.27418042
28MP0008932_abnormal_embryonic_tissue2.22826777
29MP0009379_abnormal_foot_pigmentation2.22036983
30MP0001730_embryonic_growth_arrest2.14185040
31MP0009840_abnormal_foam_cell2.12062528
32MP0000678_abnormal_parathyroid_gland2.11164180
33MP0000537_abnormal_urethra_morphology2.03236077
34MP0003566_abnormal_cell_adhesion2.01266469
35MP0001929_abnormal_gametogenesis2.00390552
36MP0005623_abnormal_meninges_morphology1.99791881
37MP0002877_abnormal_melanocyte_morpholog1.95589044
38MP0002249_abnormal_larynx_morphology1.95529847
39MP0002089_abnormal_postnatal_growth/wei1.93271209
40MP0000751_myopathy1.92455820
41MP0008995_early_reproductive_senescence1.86597930
42MP0004147_increased_porphyrin_level1.86343702
43* MP0002210_abnormal_sex_determination1.80107440
44MP0001672_abnormal_embryogenesis/_devel1.78425980
45MP0005380_embryogenesis_phenotype1.78425980
46MP0003329_amyloid_beta_deposits1.75120765
47MP0000350_abnormal_cell_proliferation1.74138592
48* MP0003698_abnormal_male_reproductive1.71874683
49MP0008007_abnormal_cellular_replicative1.70069212
50MP0002102_abnormal_ear_morphology1.67554269
51MP0004885_abnormal_endolymph1.67288453
52MP0004859_abnormal_synaptic_plasticity1.63833663
53MP0003279_aneurysm1.59657370
54MP0003385_abnormal_body_wall1.56200081
55MP0000003_abnormal_adipose_tissue1.55490586
56* MP0001145_abnormal_male_reproductive1.52898826
57MP0004185_abnormal_adipocyte_glucose1.51477548
58MP0010030_abnormal_orbit_morphology1.49722055
59MP0003984_embryonic_growth_retardation1.49533590
60MP0002080_prenatal_lethality1.48697449
61MP0001697_abnormal_embryo_size1.48263330
62MP0001293_anophthalmia1.46398612
63MP0003942_abnormal_urinary_system1.45315555
64MP0003315_abnormal_perineum_morphology1.44470646
65MP0002088_abnormal_embryonic_growth/wei1.44239022
66MP0009053_abnormal_anal_canal1.40889265
67MP0005423_abnormal_somatic_nervous1.40532927
68MP0000733_abnormal_muscle_development1.37058509
69MP0001299_abnormal_eye_distance/1.35535088
70* MP0000653_abnormal_sex_gland1.33381459
71MP0002085_abnormal_embryonic_tissue1.33194946
72MP0000049_abnormal_middle_ear1.32763600
73* MP0002161_abnormal_fertility/fecundity1.30578207
74MP0005076_abnormal_cell_differentiation1.30264085
75MP0002160_abnormal_reproductive_system1.28526298
76MP0003221_abnormal_cardiomyocyte_apopto1.26100203
77MP0000579_abnormal_nail_morphology1.25530531
78MP0010307_abnormal_tumor_latency1.25191581
79MP0003172_abnormal_lysosome_physiology1.24747743
80MP0000534_abnormal_ureter_morphology1.24095635
81MP0009384_cardiac_valve_regurgitation1.20354402
82MP0003938_abnormal_ear_development1.19733630
83MP0002084_abnormal_developmental_patter1.19019311
84MP0001348_abnormal_lacrimal_gland1.18241632
85MP0003453_abnormal_keratinocyte_physiol1.18221760
86MP0005375_adipose_tissue_phenotype1.15718902
87MP0001661_extended_life_span1.14469743
88MP0002697_abnormal_eye_size1.14456536
89MP0000759_abnormal_skeletal_muscle1.12914303
90MP0002254_reproductive_system_inflammat1.11913415
91MP0005666_abnormal_adipose_tissue1.11382190
92MP0006292_abnormal_olfactory_placode1.11375909
93MP0000313_abnormal_cell_death1.07995855
94MP0005395_other_phenotype1.06548120
95MP0003567_abnormal_fetal_cardiomyocyte1.06034116
96MP0000358_abnormal_cell_content/1.04314194
97MP0005501_abnormal_skin_physiology1.03630492
98MP0000762_abnormal_tongue_morphology1.03597263
99MP0009672_abnormal_birth_weight1.02885303
100MP0003634_abnormal_glial_cell1.02294307
101MP0004087_abnormal_muscle_fiber1.00826883
102MP0000428_abnormal_craniofacial_morphol1.00330554
103MP0010630_abnormal_cardiac_muscle0.99851645
104MP0005670_abnormal_white_adipose0.98541376
105MP0006035_abnormal_mitochondrial_morpho0.97812772
106MP0003119_abnormal_digestive_system0.97594366
107MP0005171_absent_coat_pigmentation0.97516177
108MP0000750_abnormal_muscle_regeneration0.97167573
109MP0010368_abnormal_lymphatic_system0.96667831
110MP0002086_abnormal_extraembryonic_tissu0.94318080
111MP0003091_abnormal_cell_migration0.91858220
112MP0001915_intracranial_hemorrhage0.91284397
113MP0002060_abnormal_skin_morphology0.90811692
114MP0002132_abnormal_respiratory_system0.89643204
115MP0005451_abnormal_body_composition0.87519226
116MP0005508_abnormal_skeleton_morphology0.86055816
117MP0002116_abnormal_craniofacial_bone0.85634078
118MP0001756_abnormal_urination0.84829244
119MP0003646_muscle_fatigue0.84696627
120MP0003121_genomic_imprinting0.84672222
121MP0003699_abnormal_female_reproductive0.84249965
122MP0003937_abnormal_limbs/digits/tail_de0.83749296
123MP0005397_hematopoietic_system_phenotyp0.83270277
124MP0001545_abnormal_hematopoietic_system0.83270277
125MP0005330_cardiomyopathy0.82815001
126MP0006036_abnormal_mitochondrial_physio0.82373057
127MP0009278_abnormal_bone_marrow0.82216639
128MP0002234_abnormal_pharynx_morphology0.81210500
129MP0001958_emphysema0.81162084
130MP0001542_abnormal_bone_strength0.80747289
131MP0009333_abnormal_splenocyte_physiolog0.79109552
132MP0005389_reproductive_system_phenotype0.79079229
133MP0002127_abnormal_cardiovascular_syste0.78520372
134MP0000955_abnormal_spinal_cord0.78006507
135MP0003861_abnormal_nervous_system0.77559037
136MP0005384_cellular_phenotype0.75839008
137MP0000747_muscle_weakness0.75569014
138MP0005197_abnormal_uvea_morphology0.74391137
139MP0002092_abnormal_eye_morphology0.72266113
140MP0000767_abnormal_smooth_muscle0.72227383
141MP0002932_abnormal_joint_morphology0.71770373
142MP0008789_abnormal_olfactory_epithelium0.70286898
143MP0004084_abnormal_cardiac_muscle0.70195484
144MP0002796_impaired_skin_barrier0.70145527
145MP0003136_yellow_coat_color0.68558957
146MP0000778_abnormal_nervous_system0.68445276
147MP0009250_abnormal_appendicular_skeleto0.68359163
148MP0000462_abnormal_digestive_system0.68160871
149MP0000749_muscle_degeneration0.66472510
150MP0005621_abnormal_cell_physiology0.65578319
151MP0002114_abnormal_axial_skeleton0.65161851
152MP0003879_abnormal_hair_cell0.65075772
153MP0002925_abnormal_cardiovascular_devel0.64979256
154MP0005023_abnormal_wound_healing0.64974864
155MP0004197_abnormal_fetal_growth/weight/0.63494890
156MP0009703_decreased_birth_body0.62970943
157MP0002269_muscular_atrophy0.62737925
158MP0001529_abnormal_vocalization0.60074099
159MP0005394_taste/olfaction_phenotype0.58212278
160MP0005499_abnormal_olfactory_system0.58212278
161MP0001119_abnormal_female_reproductive0.57971869
162MP0003115_abnormal_respiratory_system0.56355766
163MP0009046_muscle_twitch0.54403839
164MP0005636_abnormal_mineral_homeostasis0.53544985
165MP0004019_abnormal_vitamin_homeostasis0.53117599
166MP0006138_congestive_heart_failure0.51917300
167MP0001727_abnormal_embryo_implantation0.49872627
168MP0001984_abnormal_olfaction0.49526613
169MP0001485_abnormal_pinna_reflex0.48950938
170MP0001440_abnormal_grooming_behavior0.48713318

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.36726229
2Gout (HP:0001997)5.04051060
3Birth length less than 3rd percentile (HP:0003561)4.84107151
4Impulsivity (HP:0100710)4.77245768
5Carpal bone hypoplasia (HP:0001498)4.71740225
6Hyperglycinemia (HP:0002154)4.17772128
7Progressive muscle weakness (HP:0003323)4.10518508
8Cerebral hypomyelination (HP:0006808)4.10207606
9Hyperacusis (HP:0010780)4.00518391
10Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.72161648
11Protrusio acetabuli (HP:0003179)3.69393287
12Premature rupture of membranes (HP:0001788)3.69289920
13Hyperglycinuria (HP:0003108)3.68010362
14Hypoplasia of the capital femoral epiphysis (HP:0003090)3.64618112
15Patellar aplasia (HP:0006443)3.64389403
16Aplasia/Hypoplasia of the patella (HP:0006498)3.58178150
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.52896601
18Rough bone trabeculation (HP:0100670)3.44206790
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.41848572
20Insomnia (HP:0100785)3.32378264
21Tetraplegia (HP:0002445)3.24883381
22Achilles tendon contracture (HP:0001771)3.06189740
23Distal upper limb amyotrophy (HP:0007149)3.04596767
24Upper limb amyotrophy (HP:0009129)3.04596767
25Ulnar bowing (HP:0003031)3.03481111
26Pancreatic fibrosis (HP:0100732)2.96813571
27Male infertility (HP:0003251)2.89259783
28Abnormality of serine family amino acid metabolism (HP:0010894)2.87197365
29Abnormality of glycine metabolism (HP:0010895)2.87197365
30Absent radius (HP:0003974)2.81103505
31Areflexia of lower limbs (HP:0002522)2.79827835
32Delusions (HP:0000746)2.79612087
33Abnormality of the labia minora (HP:0012880)2.76731540
34Abnormality of the Achilles tendon (HP:0005109)2.74856791
35Absent epiphyses (HP:0010577)2.74315035
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.74315035
37Shallow orbits (HP:0000586)2.70168031
38Irregular epiphyses (HP:0010582)2.68281081
39Absent forearm bone (HP:0003953)2.67717687
40Aplasia involving forearm bones (HP:0009822)2.67717687
41Overriding aorta (HP:0002623)2.67708205
42Long palpebral fissure (HP:0000637)2.64335676
43Abnormal respiratory motile cilium morphology (HP:0005938)2.63503962
44Abnormal respiratory epithelium morphology (HP:0012253)2.63503962
45Hyperuricemia (HP:0002149)2.60710215
46Increased purine levels (HP:0004368)2.60710215
47Broad distal phalanx of finger (HP:0009836)2.59031506
48Pustule (HP:0200039)2.58985922
49Abnormality of the umbilical cord (HP:0010881)2.58379594
50Abnormality of the aortic arch (HP:0012303)2.55702483
51Renal duplication (HP:0000075)2.53919042
52Hand muscle atrophy (HP:0009130)2.52097875
53Death in infancy (HP:0001522)2.52063957
54Truncus arteriosus (HP:0001660)2.51254870
55Bladder diverticulum (HP:0000015)2.50322059
56Aplasia/Hypoplasia involving the musculature (HP:0001460)2.49813598
57Segmental peripheral demyelination/remyelination (HP:0003481)2.49537039
58Abnormal respiratory motile cilium physiology (HP:0012261)2.48614054
59Secondary amenorrhea (HP:0000869)2.47563646
60Ureteral duplication (HP:0000073)2.47111428
61Elfin facies (HP:0004428)2.47031660
62Turricephaly (HP:0000262)2.46113933
63Premature ovarian failure (HP:0008209)2.45185566
64Fragile skin (HP:0001030)2.43554417
65Flat capital femoral epiphysis (HP:0003370)2.43366141
66Disproportionate tall stature (HP:0001519)2.42988021
67Abnormal trabecular bone morphology (HP:0100671)2.42444319
68Spinal rigidity (HP:0003306)2.42342616
69Atrophic scars (HP:0001075)2.41995389
70CNS hypomyelination (HP:0003429)2.39430255
71Vertebral compression fractures (HP:0002953)2.39360934
72Mutism (HP:0002300)2.38748906
73Mitral regurgitation (HP:0001653)2.38279472
74Genu recurvatum (HP:0002816)2.37252213
75Global brain atrophy (HP:0002283)2.36576731
76Hyperthyroidism (HP:0000836)2.36445661
77Abnormal spermatogenesis (HP:0008669)2.36238933
78Dynein arm defect of respiratory motile cilia (HP:0012255)2.35266562
79Absent/shortened dynein arms (HP:0200106)2.35266562
80Entropion (HP:0000621)2.31378003
81Breast aplasia (HP:0100783)2.31096595
82Abnormality of the anterior horn cell (HP:0006802)2.29887575
83Degeneration of anterior horn cells (HP:0002398)2.29887575
84Rhinitis (HP:0012384)2.29118031
85Aplasia/Hypoplasia of the breasts (HP:0010311)2.28271453
86Ankle contracture (HP:0006466)2.27528860
87Patellar dislocation (HP:0002999)2.27271101
88Pointed chin (HP:0000307)2.25017595
89Atrioventricular block (HP:0001678)2.24663941
90Obstructive sleep apnea (HP:0002870)2.24531621
91Ventricular fibrillation (HP:0001663)2.23043537
92Oral leukoplakia (HP:0002745)2.22677455
93Abnormality of the proximal phalanges of the hand (HP:0009834)2.22475184
94Bundle branch block (HP:0011710)2.21601403
95Supernumerary spleens (HP:0009799)2.21415558
96Oligodactyly (hands) (HP:0001180)2.19772761
97Oligodactyly (HP:0012165)2.19335128
98Chronic bronchitis (HP:0004469)2.19279088
99Increased connective tissue (HP:0009025)2.16987449
100Short middle phalanx of the 5th finger (HP:0004220)2.16830440
101Meckel diverticulum (HP:0002245)2.16097063
102Microretrognathia (HP:0000308)2.15198574
103Personality changes (HP:0000751)2.14536946
104Cervical subluxation (HP:0003308)2.14128271
105Abnormality of the tricuspid valve (HP:0001702)2.13453331
106Renovascular hypertension (HP:0100817)2.13066092
107Cerebral aneurysm (HP:0004944)2.12916259
108Muscle fiber splitting (HP:0003555)2.11504725
109Sparse lateral eyebrow (HP:0005338)2.11351781
110Poikilocytosis (HP:0004447)2.11204886
111Flat cornea (HP:0007720)2.11048217
112Distal lower limb amyotrophy (HP:0008944)2.10449448
113Multiple enchondromatosis (HP:0005701)2.10210384
114Cerebral inclusion bodies (HP:0100314)2.08382997
115Difficulty climbing stairs (HP:0003551)2.08253866
116Partial duplication of thumb phalanx (HP:0009944)2.08195841
117Abnormality of serum amino acid levels (HP:0003112)2.08047668
118Abnormality of the preputium (HP:0100587)2.06989191
119Facial hemangioma (HP:0000329)2.06891246
120Increased variability in muscle fiber diameter (HP:0003557)2.06786350
121Thin ribs (HP:0000883)2.06723566
122Ependymoma (HP:0002888)2.05601579
123Aplasia/hypoplasia of the humerus (HP:0006507)2.04448736
124Selective tooth agenesis (HP:0001592)2.03867393
125Stridor (HP:0010307)2.03688562
126Abnormality of the lower motor neuron (HP:0002366)2.03661823
127Megaloblastic anemia (HP:0001889)2.01505688
128Blue sclerae (HP:0000592)2.00852063
129Horseshoe kidney (HP:0000085)2.00507576
130Spastic tetraparesis (HP:0001285)1.98630275
131Centrally nucleated skeletal muscle fibers (HP:0003687)1.98557238
132Abnormality of the ileum (HP:0001549)1.98271181
133Deep palmar crease (HP:0006191)1.97643387
134Premature skin wrinkling (HP:0100678)1.97370694
135Myopathic facies (HP:0002058)1.96363264
136Pelvic girdle muscle weakness (HP:0003749)1.95481430
137Confusion (HP:0001289)1.93887762
138Short nail (HP:0001799)1.92969059
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92814994
140Trismus (HP:0000211)1.92384913
141Infertility (HP:0000789)1.92236361
142Small epiphyses (HP:0010585)1.91823107
143Prominent nose (HP:0000448)1.91711477
144Abnormality of the distal phalanx of the thumb (HP:0009617)1.89945307
145Coronal craniosynostosis (HP:0004440)1.89716902
146Arnold-Chiari malformation (HP:0002308)1.89281690
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.88312203
148Unsteady gait (HP:0002317)1.87909030
149Facial cleft (HP:0002006)1.87364225
150Congenital glaucoma (HP:0001087)1.86200224
151Biconcave vertebral bodies (HP:0004586)1.85822937
152Abnormality of dentin (HP:0010299)1.85777563
153Distal lower limb muscle weakness (HP:0009053)1.84633681
154Shoulder girdle muscle weakness (HP:0003547)1.84445404
155Partial duplication of the phalanx of hand (HP:0009999)1.84433217
156Split foot (HP:0001839)1.84427715
157Natal tooth (HP:0000695)1.84082491
158Duodenal stenosis (HP:0100867)1.84038599
159Small intestinal stenosis (HP:0012848)1.84038599
160Abnormality of the phalanges of the hallux (HP:0010057)1.83835634
161Cholecystitis (HP:0001082)1.83040683
162Abnormal gallbladder physiology (HP:0012438)1.83040683
163Abnormality of the thoracic spine (HP:0100711)1.81639534
164Bowel diverticulosis (HP:0005222)1.81441515
165Broad face (HP:0000283)1.81429864
166Broad metatarsal (HP:0001783)1.80015631
167Supranuclear gaze palsy (HP:0000605)1.78142384
168Atelectasis (HP:0100750)1.78077235
169Thin bony cortex (HP:0002753)1.76438087
170Lower limb amyotrophy (HP:0007210)1.76056817
171Generalized amyotrophy (HP:0003700)1.74047186
172Elbow flexion contracture (HP:0002987)1.73349264
173Hypercalcemia (HP:0003072)1.71638992
174Neurofibrillary tangles (HP:0002185)1.71375013
175Bowed forearm bones (HP:0003956)1.67389306
176Bowing of the arm (HP:0006488)1.67389306
177Abnormality of skeletal muscle fiber size (HP:0012084)1.67213541
178Annular pancreas (HP:0001734)1.65529660
179Abnormal ossification of hand bones (HP:0005921)1.62211792
180Hyperextensible skin (HP:0000974)1.61937335
181Aplasia/Hypoplasia of the sacrum (HP:0008517)1.61798694
182Aplasia involving bones of the extremities (HP:0009825)1.61217334
183Aplasia involving bones of the upper limbs (HP:0009823)1.61217334
184Aplasia of the phalanges of the hand (HP:0009802)1.61217334
185Venous abnormality (HP:0002624)1.60144709
186Mildly elevated creatine phosphokinase (HP:0008180)1.59918037
187Reticulocytosis (HP:0001923)1.59726472
188Transposition of the great arteries (HP:0001669)1.58753329
189Abnormal connection of the cardiac segments (HP:0011545)1.58753329
190Abnormal ventriculo-arterial connection (HP:0011563)1.58753329
191Megalocornea (HP:0000485)1.56664319
192Precocious puberty (HP:0000826)1.55991710
193Advanced eruption of teeth (HP:0006288)1.55831727
194Flattened epiphyses (HP:0003071)1.54792644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.83258538
2TRIB34.45766805
3WEE14.13497076
4SMG13.70817628
5AKT33.61667551
6NEK23.14330392
7EIF2AK13.08467945
8PLK42.94994765
9IRAK32.88515273
10EEF2K2.82020976
11PDK42.68834243
12PDK32.68834243
13SIK12.65242279
14BRSK22.57955855
15NEK12.56110193
16BRSK12.37855161
17PLK12.08516586
18TTN2.06804557
19TTK1.97393003
20ERN11.96934418
21CDC71.93925551
22SRPK11.92142180
23NTRK11.91461791
24ACVR1B1.89604651
25PRPF4B1.89434573
26PDK21.87401011
27DYRK31.83376633
28PLK31.73503560
29PDGFRA1.71455962
30CDK121.67968985
31PINK11.66962196
32TSSK61.61332114
33RIPK11.61039742
34STK161.57530019
35MKNK21.53804641
36TYRO31.53360402
37CHEK21.53198718
38EPHB21.49722314
39LATS21.47430839
40MAP3K101.42348602
41BRAF1.42216019
42PKN21.40266726
43AURKA1.38905963
44ARAF1.38762402
45CCNB11.37710637
46LMTK21.36632837
47DDR21.35638188
48MKNK11.34644204
49PTK21.34362602
50MAP3K111.30506036
51BMX1.26668073
52FGFR41.25272957
53PNCK1.23768269
54MAP2K31.21165268
55TAOK21.18065605
56AURKB1.16886527
57PAK41.14590286
58TLK11.14237223
59NME21.13219552
60TESK21.12217246
61CDK71.11992336
62ZAK1.09749766
63EPHA21.09196486
64MARK21.07667094
65ICK1.04761777
66CHEK11.01535780
67WNK31.00902520
68PTK60.98245830
69RPS6KA20.96249014
70STK30.94964026
71STK38L0.91824963
72LIMK10.90998810
73VRK20.89803495
74DAPK30.89775907
75CAMK1D0.88850323
76ATR0.86242402
77PAK10.86089729
78CDC42BPA0.84256026
79CAMK1G0.83301564
80EIF2AK30.83086115
81MOS0.83048673
82CDK40.80941171
83PAK60.79624772
84PRKG20.77956067
85PDPK10.77818240
86MST1R0.77774793
87VRK10.77036383
88MAP3K80.76473678
89ILK0.76470499
90TESK10.75708844
91CSNK1G30.75422842
92CDK20.72814332
93RPS6KA40.72155130
94PRKCI0.71888885
95MAP3K130.70708151
96PRKD30.69046810
97MET0.68182557
98MAPK110.68048288
99PRKD20.66910572
100DYRK1B0.66231056
101ALK0.65205598
102ABL20.65083687
103PIM20.63606924
104RPS6KL10.62749114
105RPS6KC10.62749114
106STK380.60163585
107PRKAA10.60083482
108AKT20.57052458
109CDK10.56776897
110LRRK20.55297962
111MAP3K90.54660230
112CDK30.54177320
113CSNK1E0.53055877
114DYRK20.51434033
115NME10.51165802
116CSNK1G20.50650571
117KSR20.49510197
118STK40.49431430
119CDK90.49239167
120BRD40.48843712
121RAF10.48535264
122EPHA30.48058265
123CSNK1A1L0.47410685
124SCYL20.47259136
125ATM0.46643484
126SIK20.46348779
127PRKCG0.45561729
128MAP3K60.44733553
129MAP3K30.43006000
130KDR0.42955443
131MAP3K10.42688518
132PIM10.42385896
133WNK10.42274341
134MAPK120.41029120
135FLT30.40190045
136RPS6KA60.39995896
137BCKDK0.39385510
138CSNK1G10.38895360
139CSNK2A10.37743371
140CSNK2A20.36859402
141ROCK20.36762748
142WNK40.36571170
143CAMK2G0.36557348
144MAP3K70.36216806
145RPS6KB20.35678302
146CAMKK10.35347277
147ERBB20.34721165
148HIPK20.31479655
149MTOR0.31300381
150EIF2AK20.30922262
151STK100.28271959
152TAOK10.27633597
153MAPK90.26093589
154MAPK100.24234521
155KSR10.23838165
156GSK3B0.22190203
157CDK150.21874872
158CDK11A0.21197269
159CDK140.20742555
160RPS6KA10.20675989
161MELK0.20161393
162MAP2K20.19309546
163CSNK1A10.18839114
164RPS6KA50.18517920
165CDK180.17684526
166PAK20.16853361
167MARK10.15761330

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.96323277
2RNA polymerase_Homo sapiens_hsa030204.22503107
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.06966076
4DNA replication_Homo sapiens_hsa030303.12923654
5RNA transport_Homo sapiens_hsa030133.11506615
6Folate biosynthesis_Homo sapiens_hsa007902.78624491
7Cell cycle_Homo sapiens_hsa041102.74106358
8Pyrimidine metabolism_Homo sapiens_hsa002402.51545581
9Proteasome_Homo sapiens_hsa030502.48341701
10Spliceosome_Homo sapiens_hsa030402.42203700
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.34564707
12Basal transcription factors_Homo sapiens_hsa030222.20056814
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14518076
14Mismatch repair_Homo sapiens_hsa034302.13151849
15Notch signaling pathway_Homo sapiens_hsa043302.12621612
16Vitamin digestion and absorption_Homo sapiens_hsa049772.01587479
17Base excision repair_Homo sapiens_hsa034102.01581430
18Central carbon metabolism in cancer_Homo sapiens_hsa052302.01217692
19Homologous recombination_Homo sapiens_hsa034401.94511920
20Other glycan degradation_Homo sapiens_hsa005111.94164997
21Purine metabolism_Homo sapiens_hsa002301.92581045
22Oocyte meiosis_Homo sapiens_hsa041141.92095195
23Nucleotide excision repair_Homo sapiens_hsa034201.90867283
24Pentose phosphate pathway_Homo sapiens_hsa000301.88927836
25Regulation of autophagy_Homo sapiens_hsa041401.87221688
26Bladder cancer_Homo sapiens_hsa052191.84405945
27p53 signaling pathway_Homo sapiens_hsa041151.84326368
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74387136
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.71446808
30Fanconi anemia pathway_Homo sapiens_hsa034601.68115977
31Biosynthesis of amino acids_Homo sapiens_hsa012301.61061378
32Chronic myeloid leukemia_Homo sapiens_hsa052201.59670652
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57392752
34Prion diseases_Homo sapiens_hsa050201.55728555
35ECM-receptor interaction_Homo sapiens_hsa045121.55265222
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53973154
37* Glycerophospholipid metabolism_Homo sapiens_hsa005641.52744708
38VEGF signaling pathway_Homo sapiens_hsa043701.46198235
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45192121
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.42295509
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40593455
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.40256092
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39344910
44mRNA surveillance pathway_Homo sapiens_hsa030151.34132817
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23008833
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.18439885
47Focal adhesion_Homo sapiens_hsa045101.17946725
48Sulfur relay system_Homo sapiens_hsa041221.15758763
49Glioma_Homo sapiens_hsa052141.15290276
50Non-small cell lung cancer_Homo sapiens_hsa052231.14252033
51Endometrial cancer_Homo sapiens_hsa052131.10804479
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10238831
53Insulin signaling pathway_Homo sapiens_hsa049101.08053391
54One carbon pool by folate_Homo sapiens_hsa006701.05111425
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02119628
56RNA degradation_Homo sapiens_hsa030181.01030562
57Synaptic vesicle cycle_Homo sapiens_hsa047211.00677985
58Acute myeloid leukemia_Homo sapiens_hsa052211.00207500
59Thyroid cancer_Homo sapiens_hsa052161.00191290
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.98040844
61Carbon metabolism_Homo sapiens_hsa012000.97718622
62Ribosome_Homo sapiens_hsa030100.97246257
63ErbB signaling pathway_Homo sapiens_hsa040120.96616438
64Dilated cardiomyopathy_Homo sapiens_hsa054140.95402496
65Fructose and mannose metabolism_Homo sapiens_hsa000510.94751686
66Vibrio cholerae infection_Homo sapiens_hsa051100.93652052
67Small cell lung cancer_Homo sapiens_hsa052220.91602330
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91226781
69Proteoglycans in cancer_Homo sapiens_hsa052050.90748099
70Epstein-Barr virus infection_Homo sapiens_hsa051690.90565478
71Axon guidance_Homo sapiens_hsa043600.86248542
72Melanogenesis_Homo sapiens_hsa049160.85149815
73Pancreatic cancer_Homo sapiens_hsa052120.84694623
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83544598
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80042908
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76464430
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76061514
78Renal cell carcinoma_Homo sapiens_hsa052110.74399699
79Arginine biosynthesis_Homo sapiens_hsa002200.73386549
80Melanoma_Homo sapiens_hsa052180.73136111
81N-Glycan biosynthesis_Homo sapiens_hsa005100.72480053
82Lysine degradation_Homo sapiens_hsa003100.71723695
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70319524
84Adherens junction_Homo sapiens_hsa045200.70168788
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69121822
86Endocytosis_Homo sapiens_hsa041440.67552214
87Colorectal cancer_Homo sapiens_hsa052100.67476346
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.66679488
89Fatty acid biosynthesis_Homo sapiens_hsa000610.66336274
90Amoebiasis_Homo sapiens_hsa051460.65164178
91Mineral absorption_Homo sapiens_hsa049780.64552380
92GnRH signaling pathway_Homo sapiens_hsa049120.64235790
93Selenocompound metabolism_Homo sapiens_hsa004500.64057662
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63730967
95Circadian rhythm_Homo sapiens_hsa047100.63226962
96Gap junction_Homo sapiens_hsa045400.63208776
97Steroid biosynthesis_Homo sapiens_hsa001000.62692518
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62486385
99Wnt signaling pathway_Homo sapiens_hsa043100.61314403
100Hedgehog signaling pathway_Homo sapiens_hsa043400.59050572
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58579553
102Huntingtons disease_Homo sapiens_hsa050160.58259894
103Estrogen signaling pathway_Homo sapiens_hsa049150.57751458
104* Metabolic pathways_Homo sapiens_hsa011000.53800024
105Glycerolipid metabolism_Homo sapiens_hsa005610.53660708
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53426510
107Pathways in cancer_Homo sapiens_hsa052000.51710630
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50768618
109Long-term potentiation_Homo sapiens_hsa047200.49802975
110Rap1 signaling pathway_Homo sapiens_hsa040150.49121267
111Prostate cancer_Homo sapiens_hsa052150.48031879
112Glutathione metabolism_Homo sapiens_hsa004800.47272867
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44623239
114Linoleic acid metabolism_Homo sapiens_hsa005910.38813619
115Arginine and proline metabolism_Homo sapiens_hsa003300.36705257
116Hippo signaling pathway_Homo sapiens_hsa043900.35772803
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34763854
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34061482
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33935543
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33931272
121Cardiac muscle contraction_Homo sapiens_hsa042600.33557200
122Viral carcinogenesis_Homo sapiens_hsa052030.33484125
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33301234
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.32478011
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30810614
126Pyruvate metabolism_Homo sapiens_hsa006200.29751665
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29624995
128Non-homologous end-joining_Homo sapiens_hsa034500.29133205
129mTOR signaling pathway_Homo sapiens_hsa041500.28490921
130Systemic lupus erythematosus_Homo sapiens_hsa053220.26155413
131Lysosome_Homo sapiens_hsa041420.24715408
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24150534
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23665482
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22952099
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21623990
136Butanoate metabolism_Homo sapiens_hsa006500.21583018
137Renin-angiotensin system_Homo sapiens_hsa046140.21463094
138Collecting duct acid secretion_Homo sapiens_hsa049660.21200628
139Basal cell carcinoma_Homo sapiens_hsa052170.21182959
140Sphingolipid metabolism_Homo sapiens_hsa006000.20191697
141HTLV-I infection_Homo sapiens_hsa051660.17016499
142Herpes simplex infection_Homo sapiens_hsa051680.16287026
143FoxO signaling pathway_Homo sapiens_hsa040680.15956724
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14447441
145Fatty acid metabolism_Homo sapiens_hsa012120.12120807
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11179434
147Arachidonic acid metabolism_Homo sapiens_hsa005900.10817126
148Antigen processing and presentation_Homo sapiens_hsa046120.10512532
149Inositol phosphate metabolism_Homo sapiens_hsa005620.09864185
150AMPK signaling pathway_Homo sapiens_hsa041520.09476191
151Galactose metabolism_Homo sapiens_hsa000520.09401896
152Propanoate metabolism_Homo sapiens_hsa006400.08480762
153Glucagon signaling pathway_Homo sapiens_hsa049220.08391677
154Alcoholism_Homo sapiens_hsa050340.07653194
155Dorso-ventral axis formation_Homo sapiens_hsa043200.07528461
156MicroRNAs in cancer_Homo sapiens_hsa052060.07301653
157HIF-1 signaling pathway_Homo sapiens_hsa040660.05710239

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