PTENP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. A highly homologous processed pseudogene of PTEN is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of helicase activity (GO:0051095)6.17710576
2natural killer cell activation involved in immune response (GO:0002323)5.51611569
3response to pheromone (GO:0019236)4.90242052
4pyrimidine nucleotide catabolic process (GO:0006244)4.81553937
5spermatid nucleus differentiation (GO:0007289)4.67430876
6relaxation of smooth muscle (GO:0044557)4.43961618
7DNA topological change (GO:0006265)4.39592622
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.26517076
9anatomical structure regression (GO:0060033)4.09450048
10regulation of B cell receptor signaling pathway (GO:0050855)4.07592185
11positive regulation of hair follicle development (GO:0051798)3.96068277
12positive regulation of hair cycle (GO:0042635)3.96068277
13thrombin receptor signaling pathway (GO:0070493)3.95499891
14regulation of platelet aggregation (GO:0090330)3.93559980
15cardiovascular system development (GO:0072358)3.75815349
16protein neddylation (GO:0045116)3.74737490
17pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.69332712
18energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68392628
19ATP synthesis coupled proton transport (GO:0015986)3.68392628
20plasma membrane fusion (GO:0045026)3.67536922
21regulation of memory T cell differentiation (GO:0043380)3.67032254
22translational termination (GO:0006415)3.59818719
23detection of temperature stimulus involved in sensory perception (GO:0050961)3.54985803
24detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.54985803
25viral transcription (GO:0019083)3.46983366
26ncRNA catabolic process (GO:0034661)3.34614129
27regulation of mast cell degranulation (GO:0043304)3.34052261
28motile cilium assembly (GO:0044458)3.32738199
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29762139
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28289285
31regulation of mast cell activation involved in immune response (GO:0033006)3.22666391
32melanosome transport (GO:0032402)3.13741987
33regulation of mast cell activation (GO:0033003)3.09794471
34ether lipid metabolic process (GO:0046485)3.08594173
35positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.08159623
36cellular response to exogenous dsRNA (GO:0071360)3.07629713
37interkinetic nuclear migration (GO:0022027)3.07566291
38DNA integration (GO:0015074)3.06381201
39positive regulation of mast cell activation (GO:0033005)2.99747994
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99221863
41translational elongation (GO:0006414)2.95139454
42positive regulation of interleukin-17 production (GO:0032740)2.95124616
43positive regulation of catecholamine secretion (GO:0033605)2.94023428
44pigment granule transport (GO:0051904)2.92478616
45positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.91319947
46positive regulation of regulated secretory pathway (GO:1903307)2.90367440
47establishment of protein localization to mitochondrial membrane (GO:0090151)2.89438635
48lipoxygenase pathway (GO:0019372)2.88240889
49regulation of platelet activation (GO:0010543)2.87499053
50regulation of interleukin-17 production (GO:0032660)2.86766855
51poly(A)+ mRNA export from nucleus (GO:0016973)2.86071753
52positive regulation of steroid hormone secretion (GO:2000833)2.82227870
53retina layer formation (GO:0010842)2.82144682
54establishment of melanosome localization (GO:0032401)2.81704434
55detection of temperature stimulus (GO:0016048)2.79171537
56negative regulation of muscle contraction (GO:0045932)2.78873141
57regulation of cilium movement (GO:0003352)2.76003594
58positive regulation of receptor recycling (GO:0001921)2.75322290
59negative regulation of smooth muscle contraction (GO:0045986)2.73901609
60adult feeding behavior (GO:0008343)2.72355465
61negative regulation of interleukin-17 production (GO:0032700)2.71911989
62cellular protein complex disassembly (GO:0043624)2.70248149
63regulation of T-helper 1 cell differentiation (GO:0045625)2.69949314
64cotranslational protein targeting to membrane (GO:0006613)2.68885546
65establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66529362
66DNA damage response, detection of DNA damage (GO:0042769)2.66105324
67protein targeting to ER (GO:0045047)2.66044805
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65780648
69definitive hemopoiesis (GO:0060216)2.65628042
70regulation of T-helper 2 cell differentiation (GO:0045628)2.65204298
71microtubule depolymerization (GO:0007019)2.63078102
72establishment of pigment granule localization (GO:0051905)2.62758495
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62245551
74peptidyl-threonine dephosphorylation (GO:0035970)2.60894844
75viral life cycle (GO:0019058)2.59957702
76CENP-A containing nucleosome assembly (GO:0034080)2.59409739
77cellular extravasation (GO:0045123)2.58903510
78cytoplasmic mRNA processing body assembly (GO:0033962)2.56819082
79melanosome localization (GO:0032400)2.56128854
80pituitary gland development (GO:0021983)2.55259843
81leukocyte degranulation (GO:0043299)2.55065363
82maternal behavior (GO:0042711)2.55049705
83response to peptidoglycan (GO:0032494)2.53647423
84negative regulation of phagocytosis (GO:0050765)2.53125105
85positive regulation of T cell cytokine production (GO:0002726)2.51137301
86nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.49291192
87fructose metabolic process (GO:0006000)2.46956766
88protein localization to endoplasmic reticulum (GO:0070972)2.46906587
89negative regulation of heart rate (GO:0010459)2.46596557
90opioid receptor signaling pathway (GO:0038003)2.45979450
91positive regulation of mast cell degranulation (GO:0043306)2.44504266
92positive regulation of mast cell activation involved in immune response (GO:0033008)2.44504266
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43560751
94tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43560751
95ribosomal small subunit biogenesis (GO:0042274)2.43542342
96chromatin remodeling at centromere (GO:0031055)2.43412821
97positive regulation of T-helper cell differentiation (GO:0045624)2.43232139
98deoxyribonucleotide catabolic process (GO:0009264)2.41898413
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.41873818
100negative regulation of T-helper cell differentiation (GO:0045623)2.41873818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.62917177
2GATA1_22025678_ChIP-Seq_K562_Human3.74476950
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.18260281
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16542547
5GBX2_23144817_ChIP-Seq_PC3_Human3.14681659
6FUS_26573619_Chip-Seq_HEK293_Human2.98561601
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97950973
8VDR_22108803_ChIP-Seq_LS180_Human2.92625873
9EWS_26573619_Chip-Seq_HEK293_Human2.74242547
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53848896
11SCL_19346495_ChIP-Seq_HPC-7_Human2.43499987
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.15416269
13TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15416269
14RNF2_27304074_Chip-Seq_NSC_Mouse2.09667087
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06723480
16IGF1R_20145208_ChIP-Seq_DFB_Human2.04723866
17TAF15_26573619_Chip-Seq_HEK293_Human2.03888905
18IRF1_19129219_ChIP-ChIP_H3396_Human1.84811458
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.84518944
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78214295
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77203755
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.71605648
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70939911
24ZNF274_21170338_ChIP-Seq_K562_Hela1.68888943
25ELK1_19687146_ChIP-ChIP_HELA_Human1.61118002
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60097536
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59732064
28FOXP3_21729870_ChIP-Seq_TREG_Human1.58860894
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.58328752
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55402215
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51924046
32ER_23166858_ChIP-Seq_MCF-7_Human1.51169812
33P300_19829295_ChIP-Seq_ESCs_Human1.50819490
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50814673
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49159832
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48807034
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47907649
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45903441
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45903441
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45903441
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42424866
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41743792
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40854526
44VDR_23849224_ChIP-Seq_CD4+_Human1.37307197
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.37131059
46TP53_22573176_ChIP-Seq_HFKS_Human1.36272855
47NANOG_19829295_ChIP-Seq_ESCs_Human1.33314014
48SOX2_19829295_ChIP-Seq_ESCs_Human1.33314014
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32291100
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30701131
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30574579
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.24125117
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23837116
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23733482
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18987424
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.18941898
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18903738
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.17721668
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17628809
60BCAT_22108803_ChIP-Seq_LS180_Human1.12539654
61DCP1A_22483619_ChIP-Seq_HELA_Human1.11982933
62TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10919176
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10205798
64CBP_20019798_ChIP-Seq_JUKART_Human1.10036682
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10036682
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06878123
67AR_25329375_ChIP-Seq_VCAP_Human1.06645180
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06421646
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04990400
70RUNX2_22187159_ChIP-Seq_PCA_Human1.04184519
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04020481
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01969327
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00798342
74NANOG_20526341_ChIP-Seq_ESCs_Human1.00483840
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.00276544
76TTF2_22483619_ChIP-Seq_HELA_Human0.99185833
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99178101
78FOXA1_25329375_ChIP-Seq_VCAP_Human0.98086002
79FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98086002
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.97265761
81NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94848387
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94848387
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94580388
84GATA3_26560356_Chip-Seq_TH2_Human0.94189015
85SALL4_22934838_ChIP-ChIP_CD34+_Human0.93938690
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93901649
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93727558
88AR_20517297_ChIP-Seq_VCAP_Human0.93518001
89STAT1_20625510_ChIP-Seq_HELA_Human0.93056313
90NFYB_21822215_ChIP-Seq_K562_Human0.92310713
91SMAD4_21799915_ChIP-Seq_A2780_Human0.91901993
92HTT_18923047_ChIP-ChIP_STHdh_Human0.91272489
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90583357
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90423981
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.89549003
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86859905
97IRF8_21731497_ChIP-ChIP_J774_Mouse0.86617356
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86167382
99JUN_21703547_ChIP-Seq_K562_Human0.86163352
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86003398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo5.98984499
2MP0005464_abnormal_platelet_physiology3.43666572
3MP0002928_abnormal_bile_duct3.35534379
4MP0002877_abnormal_melanocyte_morpholog3.18945696
5MP0008004_abnormal_stomach_pH2.97909132
6MP0009278_abnormal_bone_marrow2.82535813
7MP0009697_abnormal_copulation2.80078910
8MP0003303_peritoneal_inflammation2.67945218
9MP0001919_abnormal_reproductive_system2.44054237
10MP0003806_abnormal_nucleotide_metabolis2.31697771
11MP0003724_increased_susceptibility_to2.26159233
12MP0000465_gastrointestinal_hemorrhage2.13699229
13MP0000631_abnormal_neuroendocrine_gland2.13281492
14MP0003315_abnormal_perineum_morphology2.11714250
15MP0003252_abnormal_bile_duct2.00899004
16MP0008995_early_reproductive_senescence2.00672567
17MP0002102_abnormal_ear_morphology1.92832386
18MP0001270_distended_abdomen1.91908841
19MP0009764_decreased_sensitivity_to1.91290943
20MP0005646_abnormal_pituitary_gland1.81807949
21MP0005397_hematopoietic_system_phenotyp1.79248292
22MP0001545_abnormal_hematopoietic_system1.79248292
23MP0005187_abnormal_penis_morphology1.73500394
24MP0004133_heterotaxia1.72396507
25MP0002736_abnormal_nociception_after1.65028351
26MP0005389_reproductive_system_phenotype1.63821373
27MP0006035_abnormal_mitochondrial_morpho1.60196050
28MP0008789_abnormal_olfactory_epithelium1.57833932
29MP0001968_abnormal_touch/_nociception1.54128912
30MP0002653_abnormal_ependyma_morphology1.47122787
31MP0005499_abnormal_olfactory_system1.41985352
32MP0005394_taste/olfaction_phenotype1.41985352
33MP0001835_abnormal_antigen_presentation1.41967877
34MP0005410_abnormal_fertilization1.41567723
35MP0002132_abnormal_respiratory_system1.37874574
36MP0001529_abnormal_vocalization1.35021610
37MP0000462_abnormal_digestive_system1.34730190
38MP0000049_abnormal_middle_ear1.32797826
39MP0005408_hypopigmentation1.29812542
40MP0004147_increased_porphyrin_level1.29102185
41MP0002095_abnormal_skin_pigmentation1.27594918
42MP0002148_abnormal_hypersensitivity_rea1.20960024
43MP0004134_abnormal_chest_morphology1.14381481
44MP0006292_abnormal_olfactory_placode1.13169447
45MP0001664_abnormal_digestion1.10543580
46MP0002733_abnormal_thermal_nociception1.05253616
47MP0000343_altered_response_to1.04486349
48MP0002277_abnormal_respiratory_mucosa1.03197274
49MP0002160_abnormal_reproductive_system1.02335313
50MP0004808_abnormal_hematopoietic_stem1.02219873
51MP0000750_abnormal_muscle_regeneration1.02184439
52MP0002398_abnormal_bone_marrow0.99927914
53MP0006276_abnormal_autonomic_nervous0.99442253
54MP0000490_abnormal_crypts_of0.97166952
55MP0000230_abnormal_systemic_arterial0.96733881
56MP0002210_abnormal_sex_determination0.96193479
57MP0002735_abnormal_chemical_nociception0.95762360
58MP0008932_abnormal_embryonic_tissue0.93326522
59MP0001970_abnormal_pain_threshold0.92896022
60MP0004142_abnormal_muscle_tone0.91995130
61MP0005645_abnormal_hypothalamus_physiol0.91924789
62MP0001929_abnormal_gametogenesis0.90750825
63MP0002127_abnormal_cardiovascular_syste0.89812746
64MP0006036_abnormal_mitochondrial_physio0.87354721
65MP0001486_abnormal_startle_reflex0.84334579
66MP0003880_abnormal_central_pattern0.83814633
67MP0008569_lethality_at_weaning0.83127500
68MP0000653_abnormal_sex_gland0.82781822
69MP0003698_abnormal_male_reproductive0.82455885
70MP0005253_abnormal_eye_physiology0.81152845
71MP0003656_abnormal_erythrocyte_physiolo0.80007633
72MP0001790_abnormal_immune_system0.79990617
73MP0005387_immune_system_phenotype0.79990617
74MP0002837_dystrophic_cardiac_calcinosis0.77557457
75MP0001485_abnormal_pinna_reflex0.77410890
76MP0003136_yellow_coat_color0.76777802
77MP0006072_abnormal_retinal_apoptosis0.76129229
78MP0001145_abnormal_male_reproductive0.75945490
79MP0009046_muscle_twitch0.73272765
80MP0002452_abnormal_antigen_presenting0.72482263
81MP0004084_abnormal_cardiac_muscle0.71981771
82MP0005000_abnormal_immune_tolerance0.71942855
83MP0000689_abnormal_spleen_morphology0.71662294
84MP0009765_abnormal_xenobiotic_induced0.70691814
85MP0003221_abnormal_cardiomyocyte_apopto0.68788742
86MP0002429_abnormal_blood_cell0.68304879
87MP0005551_abnormal_eye_electrophysiolog0.68066651
88MP0002723_abnormal_immune_serum0.67107238
89MP0001501_abnormal_sleep_pattern0.66687984
90MP0001800_abnormal_humoral_immune0.66569662
91MP0000372_irregular_coat_pigmentation0.66480974
92MP0009785_altered_susceptibility_to0.65972584
93MP0000685_abnormal_immune_system0.65473426
94MP0008260_abnormal_autophagy0.65306839
95MP0002420_abnormal_adaptive_immunity0.65038339
96MP0001819_abnormal_immune_cell0.64856521
97MP0004197_abnormal_fetal_growth/weight/0.64600557
98MP0002722_abnormal_immune_system0.64556364
99MP0002572_abnormal_emotion/affect_behav0.64552394
100MP0009333_abnormal_splenocyte_physiolog0.63651340

Predicted human phenotypes

RankGene SetZ-score
1Alveolar cell carcinoma (HP:0006519)5.27910589
2Neoplasm of the tracheobronchial system (HP:0100552)4.78110471
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.59144996
4Thyroid-stimulating hormone excess (HP:0002925)3.87001640
5Prolonged bleeding time (HP:0003010)3.77547759
6Sex reversal (HP:0012245)3.67637021
7Abnormal sex determination (HP:0012244)3.67637021
8Ependymoma (HP:0002888)3.51177441
9Congenital, generalized hypertrichosis (HP:0004540)3.50312708
10Volvulus (HP:0002580)3.41656131
11Pulmonary infiltrates (HP:0002113)3.17225712
12Intestinal atresia (HP:0011100)3.09810038
13Median cleft lip (HP:0000161)3.05255973
14Neoplasm of the heart (HP:0100544)2.90818242
15Abnormal platelet volume (HP:0011876)2.77474516
16Glioma (HP:0009733)2.73892203
17Increased mean platelet volume (HP:0011877)2.70699696
183-Methylglutaconic aciduria (HP:0003535)2.61866512
19Oligodactyly (hands) (HP:0001180)2.52304871
20Abnormality of the astrocytes (HP:0100707)2.45909606
21Astrocytoma (HP:0009592)2.45909606
22Petechiae (HP:0000967)2.43969855
23Abnormality of T cell physiology (HP:0011840)2.38827065
24Abnormality of iron homeostasis (HP:0011031)2.35867383
25Mesomelia (HP:0003027)2.33424028
26Medulloblastoma (HP:0002885)2.29297954
27Papillary thyroid carcinoma (HP:0002895)2.29153952
28Neoplasm of the respiratory system (HP:0100606)2.28656033
29Abnormality of placental membranes (HP:0011409)2.27500466
30Amniotic constriction ring (HP:0009775)2.27500466
31Hip dysplasia (HP:0001385)2.26550732
32Increased serum ferritin (HP:0003281)2.26401088
33Menorrhagia (HP:0000132)2.25602512
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18086495
35Nephrogenic diabetes insipidus (HP:0009806)2.16378295
36Protruding tongue (HP:0010808)2.11515725
37Congenital hepatic fibrosis (HP:0002612)2.11423535
38Gastrointestinal atresia (HP:0002589)2.10252238
39Male pseudohermaphroditism (HP:0000037)2.08889763
40Neoplasm of the lung (HP:0100526)2.08598784
41Generalized hypopigmentation of hair (HP:0011358)2.08142072
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07504976
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07504976
44Specific learning disability (HP:0001328)2.05059601
45Aplastic anemia (HP:0001915)2.03139519
46B lymphocytopenia (HP:0010976)2.00626048
47Hyperglycinemia (HP:0002154)1.98944253
48Gonadal dysgenesis (HP:0000133)1.96303754
49Medial flaring of the eyebrow (HP:0010747)1.94568156
50Short tibia (HP:0005736)1.91730562
51Pallor (HP:0000980)1.91261183
52Elevated erythrocyte sedimentation rate (HP:0003565)1.91121247
53Abnormality of the columella (HP:0009929)1.89763734
54Abnormality of transition element cation homeostasis (HP:0011030)1.89677068
55Epistaxis (HP:0000421)1.89344548
56Abnormality of purine metabolism (HP:0004352)1.88670955
57Lipid accumulation in hepatocytes (HP:0006561)1.88158939
58Congenital primary aphakia (HP:0007707)1.85908564
59Oligodactyly (HP:0012165)1.85086663
60Polyphagia (HP:0002591)1.84779666
61Long nose (HP:0003189)1.81631484
62Exercise-induced muscle cramps (HP:0003710)1.81558764
63Optic neuritis (HP:0100653)1.81343877
64Retrobulbar optic neuritis (HP:0100654)1.81343877
65Abnormality of cells of the erythroid lineage (HP:0012130)1.81307129
66Gait imbalance (HP:0002141)1.80048109
67Decreased central vision (HP:0007663)1.78686506
68Pancreatic fibrosis (HP:0100732)1.77817123
69Abnormality of the axillary hair (HP:0100134)1.77626645
70Abnormality of secondary sexual hair (HP:0009888)1.77626645
71Meningitis (HP:0001287)1.77347808
72Chest pain (HP:0100749)1.76868125
73Split foot (HP:0001839)1.76039075
74Neoplasm of striated muscle (HP:0009728)1.75632045
75Aplasia/Hypoplasia of the tibia (HP:0005772)1.75624299
76Increased density of long bones (HP:0006392)1.70863556
77Acute necrotizing encephalopathy (HP:0006965)1.70631898
78Orchitis (HP:0100796)1.69502841
79Growth hormone deficiency (HP:0000824)1.69334659
80Purpura (HP:0000979)1.66580148
81Abnormality of B cell number (HP:0010975)1.65416148
82Retinal dysplasia (HP:0007973)1.65030848
83Increased IgM level (HP:0003496)1.64872883
84Abnormality of the heme biosynthetic pathway (HP:0010472)1.64104361
85Hypoplasia of the brainstem (HP:0002365)1.62348355
86Aplasia/Hypoplasia of the brainstem (HP:0007362)1.62348355
87Mitochondrial inheritance (HP:0001427)1.62257622
88Premature graying of hair (HP:0002216)1.60955550
89Gout (HP:0001997)1.60319322
90Abnormality of T cells (HP:0002843)1.60241828
91Syringomyelia (HP:0003396)1.60158558
92Spinal cord lesions (HP:0100561)1.60158558
93Bone marrow hypocellularity (HP:0005528)1.59066877
94Abnormal rod and cone electroretinograms (HP:0008323)1.59036883
95Chronic hepatic failure (HP:0100626)1.59007950
96Thyroid carcinoma (HP:0002890)1.58839961
97Clubbing of toes (HP:0100760)1.58676331
98Abnormality of alanine metabolism (HP:0010916)1.57217091
99Hyperalaninemia (HP:0003348)1.57217091
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.57217091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF14.70327143
2PINK13.75177205
3FES2.99182504
4ADRBK22.75652190
5STK38L2.61728629
6PNCK2.14482117
7BMPR1B2.13335184
8MAP3K52.10661610
9PRKCI2.07577493
10BRSK21.97799738
11BLK1.96460770
12MARK31.94019035
13ZAK1.79385655
14STK241.78438615
15MAP4K21.69653792
16DYRK31.63634982
17TGFBR11.56078073
18JAK31.41133184
19PBK1.40836133
20VRK11.39713830
21MYLK1.38707029
22CCNB11.38630635
23MATK1.34773762
24CAMK1G1.30434686
25CDK81.26960716
26MAP4K11.24524115
27IRAK21.18335427
28TAOK31.18017481
29RIPK41.12364366
30NEK21.08894101
31BCKDK1.07676022
32CSNK1G31.04291419
33TEC1.03901603
34IRAK11.01665588
35SYK1.00484026
36STK30.99590386
37WEE10.97988151
38CSNK1G20.97947430
39NUAK10.93688068
40CAMKK20.93527166
41DAPK30.92514939
42YES10.88755710
43IRAK40.87453544
44OBSCN0.87032505
45ILK0.86472163
46DYRK20.85166673
47IKBKB0.85106630
48FER0.82969551
49PIM10.79945556
50PRKCE0.79830878
51MST40.79693606
52CAMK10.79659032
53MAP3K120.78655173
54PTK2B0.77896822
55CAMK1D0.77708417
56PIK3CG0.77241588
57CDK190.77061190
58PRKG20.76146071
59BTK0.75462806
60MAP2K70.75258284
61KIT0.74898158
62GRK60.73619148
63AURKA0.72259546
64PIM20.70576959
65RPS6KA50.67489676
66CSNK1G10.66807687
67ACVR1B0.66047367
68BCR0.65323677
69RPS6KA60.65001008
70RPS6KC10.64490430
71RPS6KL10.64490430
72TXK0.64130351
73DYRK1B0.64120003
74GRK50.63914541
75CHEK20.61900004
76LYN0.60986011
77RPS6KA40.59216086
78IRAK30.58770826
79GRK10.58240650
80PKN10.57697422
81MAPK130.57437600
82NME20.57019914
83CSNK1A1L0.55814607
84TLK10.55083734
85BMPR20.54829702
86MKNK10.53446029
87ADRBK10.53401384
88PAK10.53370266
89PLK40.53156371
90MAP3K40.51056869
91TIE10.49469513
92ATR0.48972225
93UHMK10.47301837
94PLK20.47114307
95PRKG10.46878354
96FRK0.45296414
97BUB10.43713552
98PRKCQ0.43243609
99PRKCG0.41191642
100CSF1R0.41039528

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.30972536
2Parkinsons disease_Homo sapiens_hsa050122.66144972
3Olfactory transduction_Homo sapiens_hsa047402.63580153
4Hedgehog signaling pathway_Homo sapiens_hsa043402.55660937
5Homologous recombination_Homo sapiens_hsa034402.42432087
6Fanconi anemia pathway_Homo sapiens_hsa034602.33845863
7Oxidative phosphorylation_Homo sapiens_hsa001902.27584764
8Basal transcription factors_Homo sapiens_hsa030222.21118804
9Mismatch repair_Homo sapiens_hsa034302.16324921
10Regulation of autophagy_Homo sapiens_hsa041401.97454174
11RNA degradation_Homo sapiens_hsa030181.87295120
12Nitrogen metabolism_Homo sapiens_hsa009101.80809667
13Platelet activation_Homo sapiens_hsa046111.73610755
14DNA replication_Homo sapiens_hsa030301.73579407
15Huntingtons disease_Homo sapiens_hsa050161.63636712
16Systemic lupus erythematosus_Homo sapiens_hsa053221.58792438
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57719412
18Base excision repair_Homo sapiens_hsa034101.55787326
19Arachidonic acid metabolism_Homo sapiens_hsa005901.47518443
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45197389
21Alzheimers disease_Homo sapiens_hsa050101.43739434
22Alcoholism_Homo sapiens_hsa050341.41081319
23Linoleic acid metabolism_Homo sapiens_hsa005911.39624344
24Nucleotide excision repair_Homo sapiens_hsa034201.35874639
25Protein export_Homo sapiens_hsa030601.27249746
26Phototransduction_Homo sapiens_hsa047441.24234404
27Sulfur metabolism_Homo sapiens_hsa009201.24064087
28Hematopoietic cell lineage_Homo sapiens_hsa046401.20572139
29Pyrimidine metabolism_Homo sapiens_hsa002401.20207407
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18364008
31Legionellosis_Homo sapiens_hsa051341.18332000
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18177651
33GABAergic synapse_Homo sapiens_hsa047271.16213510
34Folate biosynthesis_Homo sapiens_hsa007901.13315513
35Gap junction_Homo sapiens_hsa045401.08445372
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.05881456
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04882459
38Herpes simplex infection_Homo sapiens_hsa051681.03215158
39Purine metabolism_Homo sapiens_hsa002301.02782385
40Morphine addiction_Homo sapiens_hsa050321.00307881
41Taste transduction_Homo sapiens_hsa047420.99131981
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96960982
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.95451052
44Spliceosome_Homo sapiens_hsa030400.94198731
45Graft-versus-host disease_Homo sapiens_hsa053320.93527157
46Allograft rejection_Homo sapiens_hsa053300.93358890
47Asthma_Homo sapiens_hsa053100.91964864
48Rheumatoid arthritis_Homo sapiens_hsa053230.90761227
49RNA transport_Homo sapiens_hsa030130.89977801
50Basal cell carcinoma_Homo sapiens_hsa052170.87911911
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87491338
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85753533
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85186559
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84404790
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83844690
56Serotonergic synapse_Homo sapiens_hsa047260.81664228
57Cell cycle_Homo sapiens_hsa041100.80153358
58Leishmaniasis_Homo sapiens_hsa051400.77285675
59p53 signaling pathway_Homo sapiens_hsa041150.76651957
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76572144
61Long-term depression_Homo sapiens_hsa047300.75402716
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.74190599
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73838804
64Notch signaling pathway_Homo sapiens_hsa043300.73204664
65Glutathione metabolism_Homo sapiens_hsa004800.72762749
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71066096
67Autoimmune thyroid disease_Homo sapiens_hsa053200.67941897
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.67004040
69Circadian entrainment_Homo sapiens_hsa047130.66568632
70AMPK signaling pathway_Homo sapiens_hsa041520.66073913
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63884966
72Type I diabetes mellitus_Homo sapiens_hsa049400.63787780
73Dorso-ventral axis formation_Homo sapiens_hsa043200.60856147
74Sulfur relay system_Homo sapiens_hsa041220.60847705
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.59654726
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59219218
77One carbon pool by folate_Homo sapiens_hsa006700.58051789
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58047006
79TGF-beta signaling pathway_Homo sapiens_hsa043500.57073586
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.55495124
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54345172
82Proteasome_Homo sapiens_hsa030500.51863950
83Oocyte meiosis_Homo sapiens_hsa041140.51725637
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50680329
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49657073
86Fructose and mannose metabolism_Homo sapiens_hsa000510.49488296
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47715426
88African trypanosomiasis_Homo sapiens_hsa051430.46864927
89Galactose metabolism_Homo sapiens_hsa000520.46166632
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45775311
91Chemokine signaling pathway_Homo sapiens_hsa040620.43767208
92Chemical carcinogenesis_Homo sapiens_hsa052040.43520773
93Primary immunodeficiency_Homo sapiens_hsa053400.43381027
94Malaria_Homo sapiens_hsa051440.42211370
95Phagosome_Homo sapiens_hsa041450.42193310
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41869071
97Apoptosis_Homo sapiens_hsa042100.41815505
98Cardiac muscle contraction_Homo sapiens_hsa042600.41121370
99Oxytocin signaling pathway_Homo sapiens_hsa049210.39870097
100Renin secretion_Homo sapiens_hsa049240.38414584

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »