PTGDR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.83862378
2negative regulation of cell killing (GO:0031342)5.71575493
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.71575493
4cellular response to interleukin-15 (GO:0071350)5.58878207
5tolerance induction (GO:0002507)5.56471448
6response to interleukin-15 (GO:0070672)5.34136618
7rRNA modification (GO:0000154)5.29711264
8rRNA methylation (GO:0031167)4.95869607
9ribosomal large subunit biogenesis (GO:0042273)4.90321353
10positive regulation of gamma-delta T cell activation (GO:0046645)4.71179723
11viral transcription (GO:0019083)4.68781905
12translational termination (GO:0006415)4.41741983
13regulation of interferon-beta biosynthetic process (GO:0045357)4.30411607
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29632832
15protein heterotrimerization (GO:0070208)4.19572762
16regulation of B cell receptor signaling pathway (GO:0050855)4.18935389
17regulation of gamma-delta T cell differentiation (GO:0045586)4.15112434
18antigen processing and presentation of endogenous antigen (GO:0019883)4.09120811
19corticosteroid receptor signaling pathway (GO:0031958)4.06623243
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.01755681
21T-helper cell differentiation (GO:0042093)3.98948282
22CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.98948282
23telomere maintenance via telomerase (GO:0007004)3.94110994
24ribosomal small subunit assembly (GO:0000028)3.93256646
25regulation of gamma-delta T cell activation (GO:0046643)3.92824559
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.92133717
27chromatin assembly (GO:0031497)3.91337250
28maturation of SSU-rRNA (GO:0030490)3.87684613
29positive regulation of natural killer cell differentiation (GO:0032825)3.87251844
30regulation of MHC class I biosynthetic process (GO:0045343)3.86426377
31protein targeting to ER (GO:0045047)3.83191286
32regulation of spindle organization (GO:0090224)3.80536946
33cotranslational protein targeting to membrane (GO:0006613)3.78730430
34positive regulation of steroid hormone secretion (GO:2000833)3.76401073
35regulation of mitochondrial translation (GO:0070129)3.75189007
36wound healing, spreading of epidermal cells (GO:0035313)3.74996541
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.73298246
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.69160344
39neutrophil activation involved in immune response (GO:0002283)3.66578173
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66075739
41negative regulation of T cell mediated immunity (GO:0002710)3.64395305
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.63816525
43glucocorticoid receptor signaling pathway (GO:0042921)3.63134661
44translational initiation (GO:0006413)3.62423289
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.59378871
46regulation of corticosteroid hormone secretion (GO:2000846)3.58639359
47leukocyte aggregation (GO:0070486)3.55193335
48CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.54009126
49protein localization to endoplasmic reticulum (GO:0070972)3.48835675
50positive regulation by symbiont of host defense response (GO:0052509)3.48093664
51modulation by symbiont of host defense response (GO:0052031)3.48093664
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48093664
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48093664
54positive regulation by organism of defense response of other organism involved in symbiotic interact3.48093664
55modulation by symbiont of host immune response (GO:0052553)3.48093664
56regulation of regulatory T cell differentiation (GO:0045589)3.47334998
57alpha-beta T cell differentiation involved in immune response (GO:0002293)3.46682359
58alpha-beta T cell activation involved in immune response (GO:0002287)3.46682359
59T cell differentiation involved in immune response (GO:0002292)3.46682359
60translational elongation (GO:0006414)3.45995666
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.44271295
62cellular protein complex disassembly (GO:0043624)3.43722588
63regulation of mitotic spindle organization (GO:0060236)3.42972428
64positive regulation of granulocyte differentiation (GO:0030854)3.37841962
65mitotic sister chromatid cohesion (GO:0007064)3.37762100
66regulation of DNA endoreduplication (GO:0032875)3.37481857
67regulation of T cell mediated cytotoxicity (GO:0001914)3.36899980
68positive regulation of chemokine secretion (GO:0090197)3.35178519
69positive regulation of protein dephosphorylation (GO:0035307)3.32913726
70folic acid-containing compound biosynthetic process (GO:0009396)3.31186101
71viral life cycle (GO:0019058)3.30857842
72positive regulation of T cell mediated cytotoxicity (GO:0001916)3.29892281
73RNA-dependent DNA replication (GO:0006278)3.26961252
74CD4-positive, alpha-beta T cell activation (GO:0035710)3.26547727
75neutrophil activation (GO:0042119)3.26381469
76G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.26142304
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.25552865
78rRNA processing (GO:0006364)3.24746532
79ribosomal small subunit biogenesis (GO:0042274)3.24279342
80RNA stabilization (GO:0043489)3.23199437
81mRNA stabilization (GO:0048255)3.23199437
82negative regulation of telomerase activity (GO:0051974)3.22427944
83regulation of chemokine secretion (GO:0090196)3.21363420
84alpha-beta T cell differentiation (GO:0046632)3.21354681
85negative regulation of T-helper cell differentiation (GO:0045623)3.19758842
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.19758842
87DNA unwinding involved in DNA replication (GO:0006268)3.18453343
88rRNA metabolic process (GO:0016072)3.18430888
89DNA replication checkpoint (GO:0000076)3.18428150
90chromatin assembly or disassembly (GO:0006333)3.18133287
91mature B cell differentiation involved in immune response (GO:0002313)3.16579986
92protein complex disassembly (GO:0043241)3.15174050
93positive regulation of interleukin-17 production (GO:0032740)3.14994589
94regulation of T cell tolerance induction (GO:0002664)3.14776705
95DNA replication-dependent nucleosome organization (GO:0034723)3.14721446
96DNA replication-dependent nucleosome assembly (GO:0006335)3.14721446
97detection of other organism (GO:0098543)3.14589984
98positive regulation of interleukin-1 beta secretion (GO:0050718)3.13639928
99activated T cell proliferation (GO:0050798)3.13439885
100negative regulation of phagocytosis (GO:0050765)3.12854802
101alpha-beta T cell activation (GO:0046631)3.12705110
102detection of bacterium (GO:0016045)3.12529750
103regulation of gene silencing by RNA (GO:0060966)3.12252107
104regulation of posttranscriptional gene silencing (GO:0060147)3.12252107
105regulation of gene silencing by miRNA (GO:0060964)3.12252107
106lymph node development (GO:0048535)3.10757775
107negative regulation of leukocyte mediated immunity (GO:0002704)3.06188935
108cellular extravasation (GO:0045123)3.05500380
109macrophage activation involved in immune response (GO:0002281)3.05486239
110negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.05342654
111regulation of protein dephosphorylation (GO:0035304)3.04610893
112nuclear pore complex assembly (GO:0051292)3.04137018
113macromolecular complex disassembly (GO:0032984)2.99361668
114protein localization to microtubule (GO:0035372)2.98181131
115interferon-gamma secretion (GO:0072643)2.96648261
116purinergic nucleotide receptor signaling pathway (GO:0035590)2.94260394
117respiratory burst (GO:0045730)2.94221831
118leukocyte degranulation (GO:0043299)2.93083806
119positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92404235
120regulation of mast cell degranulation (GO:0043304)2.90243300
121negative T cell selection (GO:0043383)2.89466224
122negative regulation of adaptive immune response (GO:0002820)2.87723999
123intracellular estrogen receptor signaling pathway (GO:0030520)2.87487798
124pteridine-containing compound biosynthetic process (GO:0042559)2.87375594
125somite development (GO:0061053)2.85983752
126regulation of natural killer cell mediated immunity (GO:0002715)2.85638898
127regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.85638898
128negative thymic T cell selection (GO:0045060)2.85159221
129regulation of leukocyte mediated cytotoxicity (GO:0001910)2.84924973
130positive regulation of interleukin-1 secretion (GO:0050716)2.84753562
131DNA deamination (GO:0045006)2.84412947
132negative regulation of interleukin-12 production (GO:0032695)2.83207875
133ribonucleoprotein complex biogenesis (GO:0022613)2.83071818
134negative regulation of DNA-dependent DNA replication (GO:2000104)2.82531611
135chromatin remodeling at centromere (GO:0031055)2.81002532
136protein K6-linked ubiquitination (GO:0085020)2.80599603
137regulation of mast cell activation (GO:0033003)2.80380488
138regulation of Golgi to plasma membrane protein transport (GO:0042996)2.79854294
139granulocyte activation (GO:0036230)2.79320677
140autophagic vacuole fusion (GO:0000046)2.79022368
141positive regulation of interleukin-1 beta production (GO:0032731)2.78686684
142regulation of telomere maintenance via telomerase (GO:0032210)2.78681285
143IMP biosynthetic process (GO:0006188)2.78180200
144leukocyte migration involved in inflammatory response (GO:0002523)2.77559862
145negative regulation of innate immune response (GO:0045824)2.77233606
146CENP-A containing nucleosome assembly (GO:0034080)2.76856789
147regulation of cell aging (GO:0090342)2.76839572
148microglial cell activation (GO:0001774)2.76561451
149regulation of natural killer cell differentiation (GO:0032823)2.76195800
150regulation of interleukin-6 biosynthetic process (GO:0045408)2.74643235
151DNA replication-independent nucleosome assembly (GO:0006336)2.74393520
152DNA replication-independent nucleosome organization (GO:0034724)2.74393520
153mucosal-associated lymphoid tissue development (GO:0048537)2.74336176
154Peyers patch development (GO:0048541)2.74336176
155regulation of histone H3-K9 methylation (GO:0051570)2.73888260
156dendritic cell migration (GO:0036336)2.72951118
157snRNA transcription (GO:0009301)2.71972082
158pinocytosis (GO:0006907)2.71859664
159negative regulation of cell aging (GO:0090344)2.71803876
160myeloid cell activation involved in immune response (GO:0002275)2.71699380
161regulation of isotype switching to IgG isotypes (GO:0048302)2.71296027
162antigen processing and presentation via MHC class Ib (GO:0002475)2.71056584
163positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.70969910
164negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.70950528
165postreplication repair (GO:0006301)2.69819814
166regulation of tolerance induction (GO:0002643)2.69502901
167mature B cell differentiation (GO:0002335)2.69253252
168negative regulation of smooth muscle cell differentiation (GO:0051151)2.68427445
169regulation of mRNA stability (GO:0043488)2.68381112
170pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.66971440
171histone deubiquitination (GO:0016578)2.66889351
172tRNA methylation (GO:0030488)2.66646520
173wound healing, spreading of cells (GO:0044319)2.66546078
174regulation of mast cell activation involved in immune response (GO:0033006)2.65866440
175neutrophil mediated immunity (GO:0002446)2.65309110
176production of molecular mediator involved in inflammatory response (GO:0002532)2.64577394
177negative regulation of erythrocyte differentiation (GO:0045647)2.63996852
178regulation of T cell mediated immunity (GO:0002709)2.63452624
179nuclear pore organization (GO:0006999)2.62521614
180nucleobase biosynthetic process (GO:0046112)2.62039077
181spliceosomal complex assembly (GO:0000245)2.61515952
182pseudouridine synthesis (GO:0001522)2.61382886
183regulation of interleukin-1 beta secretion (GO:0050706)2.60986894
184nuclear-transcribed mRNA catabolic process (GO:0000956)2.59030807
185regulation of alpha-beta T cell proliferation (GO:0046640)2.58141477
186negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.57725928
187negative regulation of protein autophosphorylation (GO:0031953)2.57485827
188ncRNA 3-end processing (GO:0043628)2.57247556
189translation (GO:0006412)2.56837176
190organelle membrane fusion (GO:0090174)2.56644347
191positive regulation of mast cell activation (GO:0033005)2.55597059
192mast cell activation (GO:0045576)2.55375994
193regulation of B cell differentiation (GO:0045577)2.55284514
194regulation of DNA-dependent DNA replication (GO:0090329)2.54691061
195cellular defense response (GO:0006968)2.54295410
1963-UTR-mediated mRNA stabilization (GO:0070935)2.53602344
197response to peptidoglycan (GO:0032494)2.53566655
198T cell homeostasis (GO:0043029)2.53114032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.13093775
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.45528197
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.32743051
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.20821552
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57034549
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51722297
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.49111665
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.44965667
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.30036990
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28216162
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.18206095
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03730451
13RUNX_20019798_ChIP-Seq_JUKART_Human2.85533742
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83719353
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62320204
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54332925
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48301369
18MYB_26560356_Chip-Seq_TH2_Human2.46376918
19MYC_22102868_ChIP-Seq_BL_Human2.39086640
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31050734
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29821317
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25466101
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21613667
24XRN2_22483619_ChIP-Seq_HELA_Human2.19157815
25SCL_19346495_ChIP-Seq_HPC-7_Human2.18974701
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.18666986
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.11447692
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08432857
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08230208
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.05759701
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.01664707
32MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00353874
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99758342
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99019444
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96748402
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95558817
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91675273
38GATA3_27048872_Chip-Seq_THYMUS_Human1.89981310
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.89625469
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87953648
41GATA3_26560356_Chip-Seq_TH2_Human1.85179374
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81874174
43CIITA_25753668_ChIP-Seq_RAJI_Human1.79802923
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73316207
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.72085878
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.71675031
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71292326
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.70009896
49VDR_21846776_ChIP-Seq_THP-1_Human1.68788994
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.67731494
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.65079944
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63486702
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.62788995
54TTF2_22483619_ChIP-Seq_HELA_Human1.62180944
55DCP1A_22483619_ChIP-Seq_HELA_Human1.61744691
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60859295
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60079501
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58270149
59SPI1_23127762_ChIP-Seq_K562_Human1.58031266
60KDM5A_27292631_Chip-Seq_BREAST_Human1.54687914
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54439109
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.54338692
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.50143970
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45409827
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44499625
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43142338
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.41441926
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40372602
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38550827
70TCF7_22412390_ChIP-Seq_EML_Mouse1.38372058
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38210352
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36335476
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36271612
74BCL6_27268052_Chip-Seq_Bcells_Human1.35625727
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35606905
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35293323
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35091780
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34935741
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34680373
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34440277
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.33533755
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31384032
83VDR_23849224_ChIP-Seq_CD4+_Human1.31221475
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28770398
85AR_21909140_ChIP-Seq_LNCAP_Human1.28610354
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27538226
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27149931
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26316286
89UTX_26944678_Chip-Seq_JUKART_Human1.25404592
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23489941
91KDM2B_26808549_Chip-Seq_DND41_Human1.21924293
92FOXP3_21729870_ChIP-Seq_TREG_Human1.21176569
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20665541
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20665541
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20665541
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20300569
97VDR_24763502_ChIP-Seq_THP-1_Human1.19746154
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19109618
99RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18768038
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18312148
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18108116
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17373684
103GABP_19822575_ChIP-Seq_HepG2_Human1.17138046
104MAF_26560356_Chip-Seq_TH1_Human1.16686155
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16640799
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.16626890
107GATA1_22025678_ChIP-Seq_K562_Human1.16185541
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16075773
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16060690
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15683278
111MYB_26560356_Chip-Seq_TH1_Human1.14590689
112NANOG_20526341_ChIP-Seq_ESCs_Human1.14063611
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12459731
114BCOR_27268052_Chip-Seq_Bcells_Human1.11460547
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10699533
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10077688
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10036459
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09802475
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09539525
120P300_27268052_Chip-Seq_Bcells_Human1.09055339
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08871855
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08664341
123MAF_26560356_Chip-Seq_TH2_Human1.08136696
124TFEB_21752829_ChIP-Seq_HELA_Human1.07899190
125KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07681404
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07648170
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07528223
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07202072
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06971377
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06836384
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06175797
132THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05153223
133CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04330564
134FLI1_27457419_Chip-Seq_LIVER_Mouse1.03500634
135STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03018970
136GATA3_26560356_Chip-Seq_TH1_Human1.01829309
137NCOR1_26117541_ChIP-Seq_K562_Human1.01553551
138ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00325213
139ERA_21632823_ChIP-Seq_H3396_Human1.00158038
140FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99975937
141CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99259727
142CHD1_26751641_Chip-Seq_LNCaP_Human0.98353640
143YY1_22570637_ChIP-Seq_MALME-3M_Human0.98291686
144KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98196876
145RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98092947
146CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97709867
147YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97021422
148SPI1_23547873_ChIP-Seq_NB4_Human0.96540189
149EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94973183
150POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94414001
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94346071
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94301626
153HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94281109
154GATA1_19941826_ChIP-Seq_K562_Human0.93419097
155ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92888588
156CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92685580
157MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91189606
158PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91072913
159YY1_21170310_ChIP-Seq_MESCs_Mouse0.90878680
160MYC_18940864_ChIP-ChIP_HL60_Human0.90208053
161BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90039260
162KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89631349
163TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89285355
164STAT1_20625510_ChIP-Seq_HELA_Human0.88870541
165GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88827878
166E2F1_20622854_ChIP-Seq_HELA_Human0.88139289
167BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87199003
168KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86980005
169NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84703138
170SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83856661
171HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83448944
172GATA6_25053715_ChIP-Seq_YYC3_Human0.82460873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.70143359
2MP0003303_peritoneal_inflammation4.16280398
3MP0002009_preneoplasia3.45784962
4MP0003693_abnormal_embryo_hatching3.31296637
5MP0003111_abnormal_nucleus_morphology3.03777040
6MP0004957_abnormal_blastocyst_morpholog3.02122030
7MP0000013_abnormal_adipose_tissue2.99919845
8MP0003941_abnormal_skin_development2.92230718
9MP0008058_abnormal_DNA_repair2.79237166
10MP0001835_abnormal_antigen_presentation2.75014730
11MP0010094_abnormal_chromosome_stability2.66007310
12MP0003300_gastrointestinal_ulcer2.59375943
13MP0005248_abnormal_Harderian_gland2.53038091
14MP0005671_abnormal_response_to2.50220547
15MP0005075_abnormal_melanosome_morpholog2.50144300
16MP0008007_abnormal_cellular_replicative2.45524551
17MP0005174_abnormal_tail_pigmentation2.38490945
18MP0002396_abnormal_hematopoietic_system2.34354066
19MP0005025_abnormal_response_to2.31837587
20MP0002723_abnormal_immune_serum2.31785329
21MP0002420_abnormal_adaptive_immunity2.31310339
22MP0009785_altered_susceptibility_to2.29297942
23MP0001819_abnormal_immune_cell2.28983281
24MP0002419_abnormal_innate_immunity2.25955002
25MP0002138_abnormal_hepatobiliary_system2.24664805
26MP0010307_abnormal_tumor_latency2.22779237
27MP0000685_abnormal_immune_system2.15283729
28MP0003866_abnormal_defecation2.12998778
29MP0008057_abnormal_DNA_replication2.12044133
30MP0003077_abnormal_cell_cycle2.11619700
31MP0004381_abnormal_hair_follicle2.11274871
32MP0002452_abnormal_antigen_presenting2.09351146
33MP0000003_abnormal_adipose_tissue2.05020114
34MP0009672_abnormal_birth_weight2.01647596
35MP0005076_abnormal_cell_differentiation2.01266619
36MP0005084_abnormal_gallbladder_morpholo1.99653786
37MP0000465_gastrointestinal_hemorrhage1.98657781
38MP0003828_pulmonary_edema1.92207011
39MP0002928_abnormal_bile_duct1.85113374
40MP0000015_abnormal_ear_pigmentation1.78579640
41MP0006082_CNS_inflammation1.75528574
42MP0000716_abnormal_immune_system1.72543884
43MP0000858_altered_metastatic_potential1.70066474
44MP0002132_abnormal_respiratory_system1.67746572
45MP0005083_abnormal_biliary_tract1.67441740
46MP0001845_abnormal_inflammatory_respons1.64071786
47MP0003566_abnormal_cell_adhesion1.57622416
48MP0005623_abnormal_meninges_morphology1.56885391
49MP0000689_abnormal_spleen_morphology1.56442756
50MP0003806_abnormal_nucleotide_metabolis1.55795897
51MP0005464_abnormal_platelet_physiology1.55359489
52MP0001533_abnormal_skeleton_physiology1.51417653
53MP0003656_abnormal_erythrocyte_physiolo1.50088073
54MP0000490_abnormal_crypts_of1.48176820
55MP0008469_abnormal_protein_level1.45408238
56MP0000350_abnormal_cell_proliferation1.42629313
57MP0002429_abnormal_blood_cell1.42101139
58MP0006036_abnormal_mitochondrial_physio1.41543491
59MP0008932_abnormal_embryonic_tissue1.38717955
60MP0009333_abnormal_splenocyte_physiolog1.38586336
61MP0005220_abnormal_exocrine_pancreas1.38541832
62MP0002693_abnormal_pancreas_physiology1.35014106
63MP0003448_altered_tumor_morphology1.31147363
64MP0005310_abnormal_salivary_gland1.29551098
65MP0005645_abnormal_hypothalamus_physiol1.28753732
66MP0003763_abnormal_thymus_physiology1.26876639
67MP0009703_decreased_birth_body1.25991645
68MP0000569_abnormal_digit_pigmentation1.24352716
69MP0001873_stomach_inflammation1.23300558
70MP0001730_embryonic_growth_arrest1.20511378
71MP0004185_abnormal_adipocyte_glucose1.20376171
72MP0009764_decreased_sensitivity_to1.20355545
73MP0005375_adipose_tissue_phenotype1.19296742
74MP0002877_abnormal_melanocyte_morpholog1.18724682
75MP0010155_abnormal_intestine_physiology1.18451784
76MP0003252_abnormal_bile_duct1.18091100
77MP0000462_abnormal_digestive_system1.16626708
78MP0001697_abnormal_embryo_size1.15938584
79MP0002086_abnormal_extraembryonic_tissu1.14778382
80MP0001851_eye_inflammation1.14273839
81MP0004197_abnormal_fetal_growth/weight/1.13523000
82MP0003436_decreased_susceptibility_to1.12513844
83MP0002837_dystrophic_cardiac_calcinosis1.10266326
84MP0002085_abnormal_embryonic_tissue1.09290275
85MP0001765_abnormal_ion_homeostasis1.07993124
86MP0003724_increased_susceptibility_to1.07948905
87MP0002088_abnormal_embryonic_growth/wei1.07509378
88MP0003984_embryonic_growth_retardation1.05993254
89MP0005380_embryogenesis_phenotype1.04379008
90MP0001672_abnormal_embryogenesis/_devel1.04379008
91MP0003119_abnormal_digestive_system1.04190373
92MP0003195_calcinosis1.04104757
93MP0005166_decreased_susceptibility_to1.03401876
94MP0001790_abnormal_immune_system1.03294548
95MP0005387_immune_system_phenotype1.03294548
96MP0003075_altered_response_to1.02119522
97MP0005451_abnormal_body_composition1.01572954
98MP0000703_abnormal_thymus_morphology1.00973942
99MP0004130_abnormal_muscle_cell1.00685179
100MP0002277_abnormal_respiratory_mucosa1.00573020
101MP0003123_paternal_imprinting1.00262509
102MP0010352_gastrointestinal_tract_polyps0.99675323
103MP0002084_abnormal_developmental_patter0.99149322
104MP0003283_abnormal_digestive_organ0.98449834
105MP0002111_abnormal_tail_morphology0.97546344
106MP0002080_prenatal_lethality0.95416228
107MP0008877_abnormal_DNA_methylation0.94404715
108MP0001986_abnormal_taste_sensitivity0.93296027
109MP0003172_abnormal_lysosome_physiology0.91964328
110MP0000313_abnormal_cell_death0.91792696
111MP0005397_hematopoietic_system_phenotyp0.91166809
112MP0001545_abnormal_hematopoietic_system0.91166809
113MP0003567_abnormal_fetal_cardiomyocyte0.90471967
114MP0002938_white_spotting0.90085494
115MP0002405_respiratory_system_inflammati0.89684260
116MP0002019_abnormal_tumor_incidence0.89444588
117MP0005381_digestive/alimentary_phenotyp0.89002443
118MP0004272_abnormal_basement_membrane0.88400188
119MP0003121_genomic_imprinting0.87833583
120MP0003786_premature_aging0.87338695
121MP0003011_delayed_dark_adaptation0.87010722
122MP0001346_abnormal_lacrimal_gland0.86955689
123MP0004883_abnormal_blood_vessel0.84358170
124MP0004264_abnormal_extraembryonic_tissu0.83368550
125MP0001663_abnormal_digestive_system0.82846800
126MP0005167_abnormal_blood-brain_barrier0.81661174
127MP0008004_abnormal_stomach_pH0.80233661
128MP0005000_abnormal_immune_tolerance0.79976811
129MP0001944_abnormal_pancreas_morphology0.79815384
130MP0002933_joint_inflammation0.79665466
131MP0002876_abnormal_thyroid_physiology0.79549753
132MP0003943_abnormal_hepatobiliary_system0.79265289
133MP0002638_abnormal_pupillary_reflex0.79213616
134MP0002398_abnormal_bone_marrow0.79024660
135MP0005621_abnormal_cell_physiology0.78049731
136MP0004808_abnormal_hematopoietic_stem0.77076543
137MP0000733_abnormal_muscle_development0.76604232
138MP0002006_tumorigenesis0.76432218
139MP0001764_abnormal_homeostasis0.76159752
140MP0010386_abnormal_urinary_bladder0.75673042
141MP0002909_abnormal_adrenal_gland0.74929937
142MP0005319_abnormal_enzyme/_coenzyme0.74316694
143MP0003091_abnormal_cell_migration0.73756177
144MP0002166_altered_tumor_susceptibility0.73138856
145MP0005085_abnormal_gallbladder_physiolo0.72870809
146MP0008770_decreased_survivor_rate0.72595607
147MP0001800_abnormal_humoral_immune0.72357110
148MP0008872_abnormal_physiological_respon0.72236561
149MP0003115_abnormal_respiratory_system0.72149836
150MP0005636_abnormal_mineral_homeostasis0.72125945
151MP0002722_abnormal_immune_system0.72034157
152MP0002148_abnormal_hypersensitivity_rea0.71865428
153MP0002095_abnormal_skin_pigmentation0.71820131
154MP0001664_abnormal_digestion0.71472220
155MP0005164_abnormal_response_to0.71316421
156MP0000627_abnormal_mammary_gland0.70826343
157MP0004947_skin_inflammation0.70628182
158MP0000613_abnormal_salivary_gland0.70513673
159MP0003787_abnormal_imprinting0.70342887
160MP0002163_abnormal_gland_morphology0.70295086
161MP0002133_abnormal_respiratory_system0.70112791
162MP0005365_abnormal_bile_salt0.69127088
163MP0000230_abnormal_systemic_arterial0.69113122
164MP0002078_abnormal_glucose_homeostasis0.68507493
165MP0010329_abnormal_lipoprotein_level0.67064750
166MP0009763_increased_sensitivity_to0.67045682
167MP0005379_endocrine/exocrine_gland_phen0.66149467
168MP0004019_abnormal_vitamin_homeostasis0.65962111
169MP0009642_abnormal_blood_homeostasis0.62477372
170MP0003638_abnormal_response/metabolism_0.61565506

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.55154648
2Abnormal hemoglobin (HP:0011902)5.48592763
3Myositis (HP:0100614)4.53785742
4Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.06077337
5Retrobulbar optic neuritis (HP:0100654)3.96013158
6Optic neuritis (HP:0100653)3.96013158
7Orchitis (HP:0100796)3.94939071
811 pairs of ribs (HP:0000878)3.87830651
9Acanthocytosis (HP:0001927)3.77884260
10Aplasia/Hypoplasia of the sacrum (HP:0008517)3.42348132
11Sparse scalp hair (HP:0002209)3.40149350
12Chromsome breakage (HP:0040012)3.37417270
13Elevated erythrocyte sedimentation rate (HP:0003565)3.32969423
14Pustule (HP:0200039)3.24672205
15Abnormality of the labia minora (HP:0012880)3.18451412
16Abnormality of macrophages (HP:0004311)3.16856465
17Reticulocytopenia (HP:0001896)3.15782674
18Rough bone trabeculation (HP:0100670)3.11925376
19Congenital sensorineural hearing impairment (HP:0008527)3.06547364
20Urethral obstruction (HP:0000796)3.04187535
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.03104698
22Exertional dyspnea (HP:0002875)3.01651197
23Hypochromic microcytic anemia (HP:0004840)3.01492456
24Encephalitis (HP:0002383)2.93702707
25Recurrent skin infections (HP:0001581)2.90076215
26Premature rupture of membranes (HP:0001788)2.89222819
27IgG deficiency (HP:0004315)2.87503227
28Distal lower limb amyotrophy (HP:0008944)2.84834947
29Macrocytic anemia (HP:0001972)2.83252931
30Microvesicular hepatic steatosis (HP:0001414)2.80439223
31Prostate neoplasm (HP:0100787)2.79751403
32Oral leukoplakia (HP:0002745)2.74319616
33Abnormality of T cells (HP:0002843)2.71820328
34T lymphocytopenia (HP:0005403)2.71019356
35Hypochromic anemia (HP:0001931)2.69833050
36Increased mean platelet volume (HP:0011877)2.69675636
37Upper limb muscle weakness (HP:0003484)2.67176916
38Abnormal platelet volume (HP:0011876)2.66854806
39Abnormal trabecular bone morphology (HP:0100671)2.66812611
40Eczematoid dermatitis (HP:0000976)2.65900201
41Amaurosis fugax (HP:0100576)2.62491176
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62199493
43Progressive microcephaly (HP:0000253)2.60790901
44Prominent metopic ridge (HP:0005487)2.60114153
45Keratoconjunctivitis sicca (HP:0001097)2.55937047
46Methylmalonic acidemia (HP:0002912)2.54553369
47Abnormality of T cell physiology (HP:0011840)2.53930847
48Gastrointestinal infarctions (HP:0005244)2.52384649
49Abnormality of T cell number (HP:0011839)2.51588404
50Hypoplastic pelvis (HP:0008839)2.50884835
51Missing ribs (HP:0000921)2.48383934
52Myocardial infarction (HP:0001658)2.48295680
53Prolonged bleeding time (HP:0003010)2.47968675
54Meningitis (HP:0001287)2.44832555
55Slender long bone (HP:0003100)2.44342860
56Cheilitis (HP:0100825)2.44186880
57Pallor (HP:0000980)2.44079577
58Recurrent bacterial skin infections (HP:0005406)2.43788201
59Increased IgM level (HP:0003496)2.42759872
60Increased hepatocellular lipid droplets (HP:0006565)2.42664104
61Urticaria (HP:0001025)2.42600570
62Ventricular fibrillation (HP:0001663)2.42477336
63Premature graying of hair (HP:0002216)2.42169195
64Keratoconjunctivitis (HP:0001096)2.41774646
65Ileus (HP:0002595)2.41535597
66Spinal cord compression (HP:0002176)2.41070444
67Chronic mucocutaneous candidiasis (HP:0002728)2.41054902
68Recurrent cutaneous fungal infections (HP:0011370)2.41054902
69Conjunctival hamartoma (HP:0100780)2.37997891
70Hyperinsulinemic hypoglycemia (HP:0000825)2.32269222
71Flat occiput (HP:0005469)2.32011646
72Recurrent abscess formation (HP:0002722)2.31220580
73Short nail (HP:0001799)2.30332186
74Panhypogammaglobulinemia (HP:0003139)2.29957600
75Abnormality of lateral ventricle (HP:0030047)2.29144834
76Inflammation of the large intestine (HP:0002037)2.28227596
77IgM deficiency (HP:0002850)2.28198742
78Congenital stationary night blindness (HP:0007642)2.26526573
79Volvulus (HP:0002580)2.25125321
80Fused cervical vertebrae (HP:0002949)2.24940889
81Abnormality of the metopic suture (HP:0005556)2.24875138
82Vasculitis (HP:0002633)2.24541951
83Gingival bleeding (HP:0000225)2.24092004
84Patellar aplasia (HP:0006443)2.23446479
85Hepatoblastoma (HP:0002884)2.22367066
86Petechiae (HP:0000967)2.22243228
87Protrusio acetabuli (HP:0003179)2.21285349
88Ketoacidosis (HP:0001993)2.19985382
89Supernumerary spleens (HP:0009799)2.19729108
90Abnormality of the heme biosynthetic pathway (HP:0010472)2.19240692
91Abnormality of vitamin B metabolism (HP:0004340)2.19227456
92Gastrointestinal inflammation (HP:0004386)2.17700976
93Homocystinuria (HP:0002156)2.15975926
94Abnormality of homocysteine metabolism (HP:0010919)2.15975926
95Mediastinal lymphadenopathy (HP:0100721)2.15757966
96Congenital, generalized hypertrichosis (HP:0004540)2.15597219
97Gangrene (HP:0100758)2.15528909
98Pili torti (HP:0003777)2.15010752
99Parakeratosis (HP:0001036)2.14958109
100Methylmalonic aciduria (HP:0012120)2.12754257
101Leukocytosis (HP:0001974)2.11715678
102Poikilocytosis (HP:0004447)2.11047060
103Epistaxis (HP:0000421)2.07670295
104Granulocytopenia (HP:0001913)2.06632928
105Mitochondrial inheritance (HP:0001427)2.06284461
106Large for gestational age (HP:0001520)2.06211793
107Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04540976
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04540976
109Microcytic anemia (HP:0001935)2.04458949
110Long eyelashes (HP:0000527)2.03979898
111Aplasia/Hypoplasia of the sternum (HP:0006714)2.03802174
112Albinism (HP:0001022)2.03563756
113Increased IgE level (HP:0003212)2.03262551
114Prominent nose (HP:0000448)2.02611220
115Facial diplegia (HP:0001349)2.02052215
116Dilatation of the ascending aorta (HP:0005111)2.01347094
117Absent hand (HP:0004050)2.00333676
118Pulmonary infiltrates (HP:0002113)2.00211951
119Hypomagnesemia (HP:0002917)1.98744118
120Recurrent gram-negative bacterial infections (HP:0005420)1.97889610
121Severe combined immunodeficiency (HP:0004430)1.97873144
122Aplasia/Hypoplasia of the patella (HP:0006498)1.97197095
123Ketosis (HP:0001946)1.97047966
124Acute necrotizing encephalopathy (HP:0006965)1.96083483
125Increased CSF lactate (HP:0002490)1.95946777
126Lower limb amyotrophy (HP:0007210)1.95218474
127Abnormal rod and cone electroretinograms (HP:0008323)1.95061940
128Spontaneous hematomas (HP:0007420)1.94533963
129Episodic fever (HP:0001954)1.94480742
130Joint swelling (HP:0001386)1.94418283
131Hemoptysis (HP:0002105)1.93275595
132Lipid accumulation in hepatocytes (HP:0006561)1.91349738
133Nephroblastoma (Wilms tumor) (HP:0002667)1.90314469
134Vertebral compression fractures (HP:0002953)1.90049871
135Entropion (HP:0000621)1.89976932
136Progressive macrocephaly (HP:0004481)1.89498542
137Polyneuropathy (HP:0001271)1.89350933
138Abnormality of the vitamin B12 metabolism (HP:0004341)1.88619658
139Obstructive lung disease (HP:0006536)1.88585785
140Chronic obstructive pulmonary disease (HP:0006510)1.88585785
141Acne (HP:0001061)1.87042358
142Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86737255
143Dicarboxylic aciduria (HP:0003215)1.86737255
144Abnormality of B cell number (HP:0010975)1.86191530
145Paralysis (HP:0003470)1.85831629
146Spondylolisthesis (HP:0003302)1.84567779
147Abnormality of eosinophils (HP:0001879)1.84148068
148Abnormality of the preputium (HP:0100587)1.83052253
149Pointed chin (HP:0000307)1.83005541
150Neoplasm of the pancreas (HP:0002894)1.81971482
151Embryonal renal neoplasm (HP:0011794)1.81937596
152Hypoglycemic coma (HP:0001325)1.81627597
153Hyperglycemia (HP:0003074)1.80498206
154Chronic diarrhea (HP:0002028)1.80153184
155Cellulitis (HP:0100658)1.78507375
156Hematochezia (HP:0002573)1.77243976
157Abnormal pupillary function (HP:0007686)1.76872054
158Abnormal mitochondria in muscle tissue (HP:0008316)1.76784873
159Increased serum ferritin (HP:0003281)1.76529571
160Aplasia/Hypoplasia of the uvula (HP:0010293)1.75509527
161Ependymoma (HP:0002888)1.75246579
162Hepatic necrosis (HP:0002605)1.74624028
163Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74517927
164Pulmonary embolism (HP:0002204)1.74342699
165Recurrent fungal infections (HP:0002841)1.73890795
166Gingivitis (HP:0000230)1.73173921
167Trismus (HP:0000211)1.73146966
168Hepatocellular necrosis (HP:0001404)1.71762287
169Broad face (HP:0000283)1.70054083
170Bicuspid aortic valve (HP:0001647)1.68506400
171Autoimmune thrombocytopenia (HP:0001973)1.68317618
172Deep palmar crease (HP:0006191)1.68282197
173Sparse lateral eyebrow (HP:0005338)1.68007021
174Abnormality of chromosome stability (HP:0003220)1.67737709
175Breast hypoplasia (HP:0003187)1.67408555
176Thick eyebrow (HP:0000574)1.66815045
177Horseshoe kidney (HP:0000085)1.66452772
178Severe short stature (HP:0003510)1.65468471
179Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.64097890
180Pelvic girdle muscle weakness (HP:0003749)1.62328926
181Abnormal number of erythroid precursors (HP:0012131)1.61239999
182Myelodysplasia (HP:0002863)1.60958656
183Anorexia (HP:0002039)1.60745318
184Birth length less than 3rd percentile (HP:0003561)1.60132498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.48583387
2EPHA24.13266466
3GRK63.15870073
4CDK123.07793695
5RIPK43.06378249
6BRD42.96944701
7DYRK32.82048850
8RIPK12.79343411
9NME22.74757227
10TXK2.70743495
11PIM22.66452182
12EIF2AK12.60325777
13TNK22.55422027
14ZAK2.52158102
15IRAK32.50212871
16MAP2K32.45888383
17WNK42.40097314
18MAP2K62.15100856
19FRK1.90827140
20TYK21.89902740
21NLK1.86979074
22SYK1.85276312
23ACVR1B1.78121548
24ALK1.72799970
25IKBKE1.67650962
26BTK1.59258612
27SRPK11.57925577
28STK161.54929800
29LYN1.54507302
30VRK11.54466947
31PKN21.53218604
32MAP4K11.53059440
33MAP2K21.51730602
34KIT1.48902002
35DMPK1.39772383
36JAK11.39140290
37RPS6KA41.36738320
38MAP3K141.36293635
39NME11.36085921
40TBK11.35687863
41ERN11.35031556
42NUAK11.35020468
43CDK71.29254823
44MATK1.27847218
45TESK21.26352087
46CAMKK21.22696036
47DYRK1B1.22496981
48MKNK21.21639096
49LMTK21.19953241
50IKBKB1.17693614
51CHEK21.16883473
52IRAK41.16015807
53MAP4K21.14758554
54MST41.13762465
55TAOK11.13408355
56ITK1.12444804
57MAPK71.07073208
58TTK1.05954141
59AURKB1.05438050
60PLK11.04666327
61PIM11.03946518
62CSK1.03530425
63RPS6KA51.02734401
64NEK20.98698245
65CDK190.97934537
66WNK10.97220067
67TSSK60.94524013
68PHKG20.94511930
69PHKG10.94511930
70CSF1R0.93870064
71MAP3K80.93251969
72MAP3K30.92605543
73NEK90.91794195
74PRKCI0.86197771
75CDC70.85961815
76TAOK30.85885443
77STK40.85364687
78DAPK20.85012871
79AURKA0.82864623
80OXSR10.82235466
81SGK20.82189939
82MKNK10.81488919
83FES0.80063849
84MAP3K20.79337489
85STK110.79033236
86MAPK120.79018481
87MAP3K110.78691824
88ATM0.78664731
89BUB10.75246956
90CDK40.74462180
91ADRBK20.73969123
92PTK2B0.72992472
93HIPK20.72025288
94EPHB10.70984818
95GRK10.70357990
96WEE10.70081658
97STK100.70067263
98CHEK10.68388097
99PASK0.67434303
100FLT30.67194854
101ATR0.66718141
102CDK20.66462222
103EIF2AK20.66096992
104PRKDC0.65859110
105TRIB30.65482549
106FGR0.64843678
107CDK60.64664135
108PDK10.63746958
109ABL20.63727197
110CSNK1E0.63689747
111PDPK10.63516593
112PRKG20.63456480
113SGK2230.63086750
114SGK4940.63086750
115MAP3K10.61882914
116PINK10.61558519
117MAP2K40.60843426
118CDK30.60530892
119MAP3K100.60348043
120MTOR0.59615167
121PRKD20.59183255
122BLK0.58867064
123MAP2K10.58653921
124OBSCN0.57927383
125CDK90.56423151
126ERBB40.55891499
127MARK20.53638210
128TTN0.52515901
129CAMK1D0.51076421
130CSNK2A20.49765128
131FGFR30.49057748
132RPS6KA60.48293161
133MAPK150.48217673
134PBK0.48144967
135ADRBK10.46982406
136JAK20.46743675
137CAMK1G0.46443821
138SGK30.46427343
139PRKCQ0.44792966
140DAPK30.44094515
141LCK0.43897240
142JAK30.42865525
143RPS6KC10.42141961
144RPS6KL10.42141961
145BMPR1B0.42049160
146LATS20.41318698
147INSRR0.41284788
148CLK10.40978173
149SGK10.40828914
150MAPK10.40657320
151STK390.39666716
152AKT10.38895463
153KSR20.38268035
154MARK30.38070534
155IRAK10.37540892
156ZAP700.36563590
157PKN10.36460706
158MAPK140.34827420
159MELK0.34574100
160CDK10.33460682
161CAMK40.33030658
162GSK3A0.32890670
163GSK3B0.32028322
164HCK0.31035824
165MAPK30.30519079
166ABL10.30354058
167BMX0.30291452
168PRKAA20.30133785
169PAK40.30124967
170TEC0.29923052
171PAK20.29670272

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.06341249
2Systemic lupus erythematosus_Homo sapiens_hsa053223.44046300
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04352616
4RNA polymerase_Homo sapiens_hsa030203.03146036
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.93270505
6Mismatch repair_Homo sapiens_hsa034302.58565349
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.52036748
8Type I diabetes mellitus_Homo sapiens_hsa049402.48548464
9Homologous recombination_Homo sapiens_hsa034402.47257121
10Allograft rejection_Homo sapiens_hsa053302.38945067
11DNA replication_Homo sapiens_hsa030302.36437662
12Autoimmune thyroid disease_Homo sapiens_hsa053202.26637637
13Spliceosome_Homo sapiens_hsa030402.23246656
14Protein export_Homo sapiens_hsa030602.20972989
15SNARE interactions in vesicular transport_Homo sapiens_hsa041302.14201393
16Graft-versus-host disease_Homo sapiens_hsa053322.05348084
17Regulation of autophagy_Homo sapiens_hsa041401.96844074
18Lysine degradation_Homo sapiens_hsa003101.93299256
19mRNA surveillance pathway_Homo sapiens_hsa030151.92871177
20Alcoholism_Homo sapiens_hsa050341.88865057
21One carbon pool by folate_Homo sapiens_hsa006701.87447368
22Cell cycle_Homo sapiens_hsa041101.79446008
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76164269
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76003378
25Fanconi anemia pathway_Homo sapiens_hsa034601.70936839
26RNA transport_Homo sapiens_hsa030131.69594490
27Staphylococcus aureus infection_Homo sapiens_hsa051501.66254726
28Antigen processing and presentation_Homo sapiens_hsa046121.65706815
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.65383734
30Sulfur relay system_Homo sapiens_hsa041221.64380009
31Asthma_Homo sapiens_hsa053101.63278391
32Collecting duct acid secretion_Homo sapiens_hsa049661.61288854
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.55376046
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48737998
35Pyrimidine metabolism_Homo sapiens_hsa002401.43425325
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36828579
37Viral carcinogenesis_Homo sapiens_hsa052031.35381805
38African trypanosomiasis_Homo sapiens_hsa051431.31639035
39Basal transcription factors_Homo sapiens_hsa030221.31305723
40Vitamin digestion and absorption_Homo sapiens_hsa049771.29087008
41Bladder cancer_Homo sapiens_hsa052191.26266052
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25376172
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22779490
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22418353
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20702445
46Nucleotide excision repair_Homo sapiens_hsa034201.20546955
47Chemokine signaling pathway_Homo sapiens_hsa040621.19963667
48Legionellosis_Homo sapiens_hsa051341.18415355
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.16170506
50Non-homologous end-joining_Homo sapiens_hsa034501.15823565
51Epstein-Barr virus infection_Homo sapiens_hsa051691.13144992
52Herpes simplex infection_Homo sapiens_hsa051681.10547025
53Base excision repair_Homo sapiens_hsa034101.10193447
54Oxidative phosphorylation_Homo sapiens_hsa001901.10075864
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07676775
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06612247
57p53 signaling pathway_Homo sapiens_hsa041151.06224888
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04863018
59Primary immunodeficiency_Homo sapiens_hsa053401.01593476
60Acute myeloid leukemia_Homo sapiens_hsa052210.99614016
61MicroRNAs in cancer_Homo sapiens_hsa052060.96635880
62RNA degradation_Homo sapiens_hsa030180.95725607
63Parkinsons disease_Homo sapiens_hsa050120.95368191
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92992529
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.92797358
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92307327
67Chronic myeloid leukemia_Homo sapiens_hsa052200.91344245
68Huntingtons disease_Homo sapiens_hsa050160.90511156
69Other glycan degradation_Homo sapiens_hsa005110.89611661
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86679706
71Pancreatic cancer_Homo sapiens_hsa052120.85812439
72HTLV-I infection_Homo sapiens_hsa051660.85033475
73Prolactin signaling pathway_Homo sapiens_hsa049170.83114463
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82865806
75Apoptosis_Homo sapiens_hsa042100.79256938
76Renal cell carcinoma_Homo sapiens_hsa052110.76869100
77Malaria_Homo sapiens_hsa051440.75203952
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74806928
79Osteoclast differentiation_Homo sapiens_hsa043800.74760442
80Leishmaniasis_Homo sapiens_hsa051400.74723667
81TNF signaling pathway_Homo sapiens_hsa046680.73778420
82Sulfur metabolism_Homo sapiens_hsa009200.73457605
83Proteasome_Homo sapiens_hsa030500.72970106
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68438113
85B cell receptor signaling pathway_Homo sapiens_hsa046620.68357914
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67328083
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66609673
88Alzheimers disease_Homo sapiens_hsa050100.66576751
89Prostate cancer_Homo sapiens_hsa052150.65776750
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65095909
91Hematopoietic cell lineage_Homo sapiens_hsa046400.64618923
92Glioma_Homo sapiens_hsa052140.64078547
93Renin secretion_Homo sapiens_hsa049240.63903293
94Hepatitis B_Homo sapiens_hsa051610.63460528
95T cell receptor signaling pathway_Homo sapiens_hsa046600.62861664
96Nitrogen metabolism_Homo sapiens_hsa009100.62800090
97Toxoplasmosis_Homo sapiens_hsa051450.62633077
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60732112
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59634878
100Rheumatoid arthritis_Homo sapiens_hsa053230.59603101
101Viral myocarditis_Homo sapiens_hsa054160.58997092
102Oocyte meiosis_Homo sapiens_hsa041140.58942172
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.58241836
104Arachidonic acid metabolism_Homo sapiens_hsa005900.58217068
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57780615
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57754600
107Measles_Homo sapiens_hsa051620.57390883
108Insulin resistance_Homo sapiens_hsa049310.56604291
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.55611789
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55394700
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55275250
112Tight junction_Homo sapiens_hsa045300.55163357
113Insulin secretion_Homo sapiens_hsa049110.55089855
114Cardiac muscle contraction_Homo sapiens_hsa042600.54128787
115Platelet activation_Homo sapiens_hsa046110.52509624
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51934778
117ECM-receptor interaction_Homo sapiens_hsa045120.51041115
118Estrogen signaling pathway_Homo sapiens_hsa049150.49829007
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48883110
120Small cell lung cancer_Homo sapiens_hsa052220.48561410
121Proteoglycans in cancer_Homo sapiens_hsa052050.46780455
122Hippo signaling pathway_Homo sapiens_hsa043900.45973573
123Wnt signaling pathway_Homo sapiens_hsa043100.45949651
124Dorso-ventral axis formation_Homo sapiens_hsa043200.45353623
125Phagosome_Homo sapiens_hsa041450.45336993
126Influenza A_Homo sapiens_hsa051640.44947432
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.44854695
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44445480
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43961726
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43600371
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43343207
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.42905800
133Adherens junction_Homo sapiens_hsa045200.42291436
134Shigellosis_Homo sapiens_hsa051310.41305310
135Inositol phosphate metabolism_Homo sapiens_hsa005620.41098351
136Non-small cell lung cancer_Homo sapiens_hsa052230.40296568
137N-Glycan biosynthesis_Homo sapiens_hsa005100.39837436
138Melanoma_Homo sapiens_hsa052180.39604445
139Peroxisome_Homo sapiens_hsa041460.39546819
140Tuberculosis_Homo sapiens_hsa051520.39461216
141Purine metabolism_Homo sapiens_hsa002300.39247957
142Pentose phosphate pathway_Homo sapiens_hsa000300.38643689
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38495755
144Focal adhesion_Homo sapiens_hsa045100.37272830
145Fat digestion and absorption_Homo sapiens_hsa049750.36306158
146Hepatitis C_Homo sapiens_hsa051600.36222512
147Pertussis_Homo sapiens_hsa051330.35303801
148VEGF signaling pathway_Homo sapiens_hsa043700.33357186
149Folate biosynthesis_Homo sapiens_hsa007900.32025961
150Ether lipid metabolism_Homo sapiens_hsa005650.31211639
151Glycerolipid metabolism_Homo sapiens_hsa005610.29550272
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29464645
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28406591
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.27051972
155Calcium signaling pathway_Homo sapiens_hsa040200.24425145

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