PTGDS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)7.09839846
2ensheathment of neurons (GO:0007272)5.83685674
3axon ensheathment (GO:0008366)5.83685674
4myelination (GO:0042552)5.79653071
5regulation of synaptic vesicle exocytosis (GO:2000300)5.68926186
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.96584809
7regulation of synaptic vesicle transport (GO:1902803)4.89410001
8myelin maintenance (GO:0043217)4.79676973
9neurotransmitter secretion (GO:0007269)4.68557499
10L-amino acid import (GO:0043092)4.60422207
11creatine metabolic process (GO:0006600)4.49818056
12regulation of neuronal synaptic plasticity (GO:0048168)4.44808492
13oligodendrocyte differentiation (GO:0048709)4.35144929
14regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.34213429
15negative regulation of protein localization to cell surface (GO:2000009)4.33597014
16positive regulation of synapse maturation (GO:0090129)4.26927794
17fatty acid elongation (GO:0030497)4.26671364
18long-chain fatty acid biosynthetic process (GO:0042759)4.24395189
19cell communication by electrical coupling (GO:0010644)4.23541516
20presynaptic membrane organization (GO:0097090)4.09636703
21astrocyte development (GO:0014002)3.98100196
22glycine transport (GO:0015816)3.91562784
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.86316079
24cellular sodium ion homeostasis (GO:0006883)3.81841160
25neurotransmitter transport (GO:0006836)3.79416919
26neuron cell-cell adhesion (GO:0007158)3.77367437
27adult walking behavior (GO:0007628)3.76389328
28cellular potassium ion homeostasis (GO:0030007)3.76068536
29potassium ion import (GO:0010107)3.73979806
30neuronal action potential propagation (GO:0019227)3.72764262
31apical protein localization (GO:0045176)3.65219331
32postsynaptic membrane organization (GO:0001941)3.64140093
33exploration behavior (GO:0035640)3.63337657
34positive regulation of dendritic spine development (GO:0060999)3.60584945
35regulation of synapse structural plasticity (GO:0051823)3.59784731
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.58724997
37presynaptic membrane assembly (GO:0097105)3.58120801
38neurotransmitter uptake (GO:0001504)3.58101289
39amino acid import (GO:0043090)3.55547963
40neuron remodeling (GO:0016322)3.54635782
41negative regulation of neurotransmitter transport (GO:0051589)3.53939285
42regulation of glutamate receptor signaling pathway (GO:1900449)3.53267983
43neuromuscular process controlling balance (GO:0050885)3.52562795
44regulation of ARF protein signal transduction (GO:0032012)3.51871325
45regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.48476312
46regulation of neurotransmitter levels (GO:0001505)3.47440233
47import into cell (GO:0098657)3.47209670
48neurotransmitter-gated ion channel clustering (GO:0072578)3.46925475
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44798062
50regulation of cell communication by electrical coupling (GO:0010649)3.44769609
51cell communication involved in cardiac conduction (GO:0086065)3.43688743
52regulation of synapse maturation (GO:0090128)3.42078591
53regulation of synaptic plasticity (GO:0048167)3.42043649
54asymmetric protein localization (GO:0008105)3.41705123
55cerebellar granule cell differentiation (GO:0021707)3.41108060
56peptidyl-tyrosine autophosphorylation (GO:0038083)3.41088975
57gamma-aminobutyric acid transport (GO:0015812)3.38385363
58negative regulation of neurotransmitter secretion (GO:0046929)3.37293631
59regulation of neurotransmitter secretion (GO:0046928)3.34816200
60peripheral nervous system axon ensheathment (GO:0032292)3.33031806
61myelination in peripheral nervous system (GO:0022011)3.33031806
62synaptic vesicle maturation (GO:0016188)3.32628957
63positive regulation of membrane potential (GO:0045838)3.31715886
64regulation of collateral sprouting (GO:0048670)3.28782210
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28400785
66glycerophospholipid catabolic process (GO:0046475)3.26536064
67positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26452485
68detection of calcium ion (GO:0005513)3.25149183
69synaptic vesicle endocytosis (GO:0048488)3.24854065
70activation of protein kinase A activity (GO:0034199)3.24816627
71transmission of nerve impulse (GO:0019226)3.24602957
72response to methylmercury (GO:0051597)3.23596455
73positive regulation of oligodendrocyte differentiation (GO:0048714)3.22827463
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22249840
75establishment of mitochondrion localization (GO:0051654)3.21775843
76potassium ion homeostasis (GO:0055075)3.17859957
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16715441
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10813592
79peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.08217544
80negative regulation of JUN kinase activity (GO:0043508)3.08182693
81ionotropic glutamate receptor signaling pathway (GO:0035235)3.07384626
82regulation of neurotransmitter transport (GO:0051588)3.07167385
83dendritic spine morphogenesis (GO:0060997)3.05099100
84cerebellar Purkinje cell differentiation (GO:0021702)3.04586347
85sodium ion export (GO:0071436)3.03958954
86neuronal ion channel clustering (GO:0045161)3.03397550
87regulation of dendritic spine development (GO:0060998)3.02646439
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.00919121
89cytoskeletal anchoring at plasma membrane (GO:0007016)2.99570482
90negative regulation of acute inflammatory response (GO:0002674)2.98739601
91adhesion of symbiont to host cell (GO:0044650)2.98409086
92virion attachment to host cell (GO:0019062)2.98409086
93regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.98237405
94regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.97315998
95regulation of postsynaptic membrane potential (GO:0060078)2.95210612
96locomotory exploration behavior (GO:0035641)2.94759665
97auditory behavior (GO:0031223)2.93674784
98layer formation in cerebral cortex (GO:0021819)2.93658356
99synaptic vesicle exocytosis (GO:0016079)2.93167771
100membrane tubulation (GO:0097320)2.92703747
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92199731
102substantia nigra development (GO:0021762)2.90646660
103regulation of vesicle fusion (GO:0031338)2.88924504
104glutamate receptor signaling pathway (GO:0007215)2.87957746
105response to redox state (GO:0051775)2.86068961
106long-term synaptic potentiation (GO:0060291)2.82409382
107positive regulation of potassium ion transport (GO:0043268)2.82043728
108response to lead ion (GO:0010288)2.82012171
109positive regulation of action potential (GO:0045760)2.81892515
110positive regulation of neurotransmitter transport (GO:0051590)2.81529122
111dendritic spine organization (GO:0097061)2.79026765
112positive regulation of neurotransmitter secretion (GO:0001956)2.78058884
113L-glutamate transport (GO:0015813)2.77317286
114negative regulation of dendrite morphogenesis (GO:0050774)2.76848402
115synaptic transmission, glutamatergic (GO:0035249)2.76593771
116negative regulation of axonogenesis (GO:0050771)2.75529576
117membrane depolarization during action potential (GO:0086010)2.75263787
118limb bud formation (GO:0060174)2.74682163
119regulation of synaptic transmission (GO:0050804)2.74393841
120cerebellar Purkinje cell layer development (GO:0021680)2.73506535
121regulation of short-term neuronal synaptic plasticity (GO:0048172)2.72939971
122L-phenylalanine catabolic process (GO:0006559)2.71459850
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.71459850
124adult locomotory behavior (GO:0008344)2.71212739
125regulation of voltage-gated calcium channel activity (GO:1901385)2.70695196
126positive regulation of potassium ion transmembrane transport (GO:1901381)2.70128067
127glutamate secretion (GO:0014047)2.69934545
128vocalization behavior (GO:0071625)2.67728840
129membrane depolarization (GO:0051899)2.67015847
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66389606
131protein localization to synapse (GO:0035418)2.65639408
132protein palmitoylation (GO:0018345)2.65354012
133regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.64363128
134regulation of interleukin-13 production (GO:0032656)2.63488508
135negative regulation of macroautophagy (GO:0016242)2.62223189
136dendrite morphogenesis (GO:0048813)2.62062551
137cellular response to epinephrine stimulus (GO:0071872)2.58309991
138neuron recognition (GO:0008038)2.57756019
139neuromuscular process controlling posture (GO:0050884)2.53730290
140gamma-aminobutyric acid signaling pathway (GO:0007214)2.52873220
141glial cell development (GO:0021782)2.52784517
142neuron-neuron synaptic transmission (GO:0007270)2.52113145
143regulation of cardiac muscle cell contraction (GO:0086004)2.51918802
144protein localization to endosome (GO:0036010)2.51412388
145long-term memory (GO:0007616)2.49950681
146eye photoreceptor cell differentiation (GO:0001754)2.49915881
147photoreceptor cell differentiation (GO:0046530)2.49915881
148regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47467882
149acidic amino acid transport (GO:0015800)2.46781124
150negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.45942206
151membrane hyperpolarization (GO:0060081)2.45926646
152axon development (GO:0061564)2.41294258
153regulation of dendritic spine morphogenesis (GO:0061001)2.41264116
154neurotransmitter catabolic process (GO:0042135)2.41192188
155axon ensheathment in central nervous system (GO:0032291)10.9436178
156central nervous system myelination (GO:0022010)10.9436178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.54376416
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.12935071
3GBX2_23144817_ChIP-Seq_PC3_Human3.01779925
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98766571
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90803762
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65409066
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65409066
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53419363
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51755591
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45121743
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38679768
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.34281677
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.32417735
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29327793
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28731948
16DROSHA_22980978_ChIP-Seq_HELA_Human2.26006333
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21643299
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18033659
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.15500888
20AR_21572438_ChIP-Seq_LNCaP_Human2.02394904
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.99845150
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.90834531
23ZFP281_18757296_ChIP-ChIP_E14_Mouse1.87388377
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85476173
25KDM2B_26808549_Chip-Seq_K562_Human1.77083528
26TAF15_26573619_Chip-Seq_HEK293_Human1.72472450
27REST_21632747_ChIP-Seq_MESCs_Mouse1.69102593
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68816320
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.67229278
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62941121
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62620612
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61556472
33* LXR_22292898_ChIP-Seq_THP-1_Human1.60863279
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60284450
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56467581
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.54752614
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.53495653
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49432374
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49092284
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48198534
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46486552
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45221227
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42851655
44* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41411321
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.39505914
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34384445
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33539382
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32688308
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.32153371
50TET1_21490601_ChIP-Seq_MESCs_Mouse1.27762707
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27412817
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.24142686
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.23489423
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22085953
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21314329
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20556713
57STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20499543
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19340113
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19142352
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18753481
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17384024
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15690314
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14081978
64SMAD4_21799915_ChIP-Seq_A2780_Human1.13443144
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13238367
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.12614798
67EGR1_19032775_ChIP-ChIP_M12_Human1.11673635
68SMC4_20622854_ChIP-Seq_HELA_Human1.11584444
69AHR_22903824_ChIP-Seq_MCF-7_Human1.09619820
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09339074
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08028993
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07924191
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06338000
74P300_19829295_ChIP-Seq_ESCs_Human1.05603592
75* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04627440
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03692876
77OCT4_19829295_ChIP-Seq_ESCs_Human1.03306001
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.03113444
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03043825
80* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02730659
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.02481058
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01699523
83KDM2B_26808549_Chip-Seq_DND41_Human1.01627591
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01160845
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00657990
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00158596
87STAT3_23295773_ChIP-Seq_U87_Human0.99318628
88ER_23166858_ChIP-Seq_MCF-7_Human0.98021242
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97347171
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97274626
91P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97041784
92SOX2_21211035_ChIP-Seq_LN229_Gbm0.96858078
93RING1B_27294783_Chip-Seq_NPCs_Mouse0.96823904
94NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95841801
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95841801
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95589706
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94618686
98NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93656809
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91493186
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90371621
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.90284578
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90179936
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.89540060
104TBX20_22328084_ChIP-Seq_HEART_Mouse0.89433458
105TBX20_22080862_ChIP-Seq_HEART_Mouse0.89433458
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89321327
107TCF4_23295773_ChIP-Seq_U87_Human0.88572562
108AR_19668381_ChIP-Seq_PC3_Human0.88411936
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88224126
110STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88220284
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87977389
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87559453
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87004648
114EOMES_21245162_ChIP-Seq_HESCs_Human0.85681163
115TRIM28_21343339_ChIP-Seq_HEK293_Human0.85597997
116* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85569303
117* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85510965
118KLF4_19829295_ChIP-Seq_ESCs_Human0.85465205
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85249943
120CTCF_27219007_Chip-Seq_Bcells_Human0.85027921
121P68_20966046_ChIP-Seq_HELA_Human0.84995156
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84966124
123CREB1_26743006_Chip-Seq_LNCaP_Human0.84518439
124TP53_18474530_ChIP-ChIP_U2OS_Human0.84367420
125DPY_21335234_ChIP-Seq_ESCs_Mouse0.83891239
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83789366
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.83780342
128POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83742524
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83468897
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.83290380
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.83150166
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83124147
133RNF2_27304074_Chip-Seq_NSC_Mouse0.83071352
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82905670
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.82392524
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.81609762
137GATA1_26923725_Chip-Seq_HPCs_Mouse0.81517240
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81460097
139PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81217068
140SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.81093682
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80816288
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.79656720
143CMYC_18555785_Chip-Seq_ESCs_Mouse0.79590423
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77416490
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.75432955
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.74807975
147SMAD4_21741376_ChIP-Seq_ESCs_Human0.73420303
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.72958472
149* MYC_19915707_ChIP-ChIP_AK7_Human0.72582330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.57556343
2MP0003880_abnormal_central_pattern4.22503014
3MP0004270_analgesia3.61556850
4MP0004859_abnormal_synaptic_plasticity3.59232977
5MP0005171_absent_coat_pigmentation3.39933624
6MP0003690_abnormal_glial_cell3.15875087
7MP0004885_abnormal_endolymph3.03973384
8MP0002272_abnormal_nervous_system2.89070294
9MP0002064_seizures2.77836559
10MP0003635_abnormal_synaptic_transmissio2.60857069
11MP0001486_abnormal_startle_reflex2.57873761
12MP0009745_abnormal_behavioral_response2.46558843
13MP0009046_muscle_twitch2.45518719
14MP0003329_amyloid_beta_deposits2.40974651
15MP0005423_abnormal_somatic_nervous2.36888407
16MP0003136_yellow_coat_color2.35364875
17MP0004142_abnormal_muscle_tone2.34850038
18MP0003879_abnormal_hair_cell2.30277300
19MP0003634_abnormal_glial_cell2.27946532
20MP0002734_abnormal_mechanical_nocicepti2.27174249
21MP0004043_abnormal_pH_regulation2.18999490
22MP0001529_abnormal_vocalization2.16187630
23MP0008569_lethality_at_weaning2.08275502
24MP0000778_abnormal_nervous_system2.07202448
25MP0003950_abnormal_plasma_membrane1.91412139
26MP0004742_abnormal_vestibular_system1.90299408
27MP0002063_abnormal_learning/memory/cond1.79522634
28MP0002572_abnormal_emotion/affect_behav1.78410482
29MP0003878_abnormal_ear_physiology1.75299600
30MP0005377_hearing/vestibular/ear_phenot1.75299600
31MP0002229_neurodegeneration1.71939606
32MP0001905_abnormal_dopamine_level1.71384977
33MP0001485_abnormal_pinna_reflex1.69137469
34MP0001440_abnormal_grooming_behavior1.67608715
35MP0000955_abnormal_spinal_cord1.63636665
36MP0001968_abnormal_touch/_nociception1.56655707
37MP0003632_abnormal_nervous_system1.56303516
38MP0004381_abnormal_hair_follicle1.53470711
39MP0004145_abnormal_muscle_electrophysio1.52778062
40MP0002067_abnormal_sensory_capabilities1.51040681
41MP0003633_abnormal_nervous_system1.50669945
42* MP0001970_abnormal_pain_threshold1.50098969
43MP0003631_nervous_system_phenotype1.46554665
44MP0002882_abnormal_neuron_morphology1.42240007
45MP0005410_abnormal_fertilization1.41791804
46MP0002736_abnormal_nociception_after1.40184045
47MP0005551_abnormal_eye_electrophysiolog1.38314021
48MP0005409_darkened_coat_color1.36408542
49MP0003075_altered_response_to1.36371545
50MP0002066_abnormal_motor_capabilities/c1.35002327
51MP0002733_abnormal_thermal_nociception1.32826750
52MP0001501_abnormal_sleep_pattern1.28877974
53MP0005167_abnormal_blood-brain_barrier1.26869105
54MP0008260_abnormal_autophagy1.26443334
55MP0005623_abnormal_meninges_morphology1.25517210
56MP0004924_abnormal_behavior1.25056234
57MP0005386_behavior/neurological_phenoty1.25056234
58MP0000747_muscle_weakness1.24223765
59MP0004215_abnormal_myocardial_fiber1.18370313
60MP0001984_abnormal_olfaction1.18113510
61MP0000604_amyloidosis1.17418403
62MP0002735_abnormal_chemical_nociception1.14156020
63MP0001299_abnormal_eye_distance/1.09574025
64MP0002184_abnormal_innervation1.08879329
65MP0001963_abnormal_hearing_physiology1.06525680
66MP0000751_myopathy1.06243046
67MP0008874_decreased_physiological_sensi1.04087106
68MP0002752_abnormal_somatic_nervous1.02812802
69MP0006276_abnormal_autonomic_nervous1.01814084
70MP0003787_abnormal_imprinting1.01375892
71MP0009780_abnormal_chondrocyte_physiolo1.00656895
72MP0001177_atelectasis1.00507941
73MP0001502_abnormal_circadian_rhythm0.99163337
74MP0004147_increased_porphyrin_level0.99010345
75MP0000462_abnormal_digestive_system0.96238200
76MP0004510_myositis0.96187096
77MP0001661_extended_life_span0.95140592
78MP0004811_abnormal_neuron_physiology0.93429639
79MP0004130_abnormal_muscle_cell0.92946755
80MP0003137_abnormal_impulse_conducting0.91587523
81MP0001346_abnormal_lacrimal_gland0.90562672
82MP0002295_abnormal_pulmonary_circulatio0.89444037
83MP0002822_catalepsy0.88972785
84MP0002557_abnormal_social/conspecific_i0.88463346
85MP0005535_abnormal_body_temperature0.87466565
86MP0002909_abnormal_adrenal_gland0.87134542
87MP0000579_abnormal_nail_morphology0.86360835
88MP0002152_abnormal_brain_morphology0.83219089
89MP0005253_abnormal_eye_physiology0.82302608
90MP0004134_abnormal_chest_morphology0.81576032
91MP0000383_abnormal_hair_follicle0.80372595
92MP0000749_muscle_degeneration0.80087695
93MP0001986_abnormal_taste_sensitivity0.79932489
94MP0005166_decreased_susceptibility_to0.79542626
95MP0001348_abnormal_lacrimal_gland0.79326857
96MP0004084_abnormal_cardiac_muscle0.78285759
97MP0002090_abnormal_vision0.78022175
98MP0005645_abnormal_hypothalamus_physiol0.77933438
99MP0004484_altered_response_of0.77748654
100MP0005195_abnormal_posterior_eye0.76510480
101MP0005257_abnormal_intraocular_pressure0.76264781
102MP0010678_abnormal_skin_adnexa0.75127726
103MP0004858_abnormal_nervous_system0.71231566
104MP0002972_abnormal_cardiac_muscle0.71197369
105MP0000372_irregular_coat_pigmentation0.71088898
106MP0000566_synostosis0.70882519
107MP0004085_abnormal_heartbeat0.70799760
108MP0005503_abnormal_tendon_morphology0.69623247
109MP0005165_increased_susceptibility_to0.69352802
110MP0004036_abnormal_muscle_relaxation0.68590894
111MP0005408_hypopigmentation0.67275758
112MP0003123_paternal_imprinting0.65697959
113MP0000639_abnormal_adrenal_gland0.64091642
114MP0003011_delayed_dark_adaptation0.64032695
115MP0003938_abnormal_ear_development0.63996612
116MP0000026_abnormal_inner_ear0.63857459
117MP0000762_abnormal_tongue_morphology0.62438842
118MP0005646_abnormal_pituitary_gland0.61307131
119MP0002638_abnormal_pupillary_reflex0.61176290
120MP0005670_abnormal_white_adipose0.59542962
121MP0003122_maternal_imprinting0.59482064
122MP0006072_abnormal_retinal_apoptosis0.59002563
123MP0002069_abnormal_eating/drinking_beha0.58071420
124MP0005058_abnormal_lysosome_morphology0.57361494
125MP0005388_respiratory_system_phenotype0.57125992
126MP0002133_abnormal_respiratory_system0.57125992
127MP0001943_abnormal_respiration0.56497040
128MP0004087_abnormal_muscle_fiber0.55613341
129MP0003045_fibrosis0.55211335
130MP0005620_abnormal_muscle_contractility0.54852828
131MP0009840_abnormal_foam_cell0.53394921
132MP0001958_emphysema0.53160601
133MP0000003_abnormal_adipose_tissue0.53127413

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.49863699
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.40241683
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.40241683
4Peripheral hypomyelination (HP:0007182)5.10826845
5Cerebral hypomyelination (HP:0006808)4.63330519
6Abnormality of the corticospinal tract (HP:0002492)4.49388171
7Myokymia (HP:0002411)4.38730699
8Cerebral inclusion bodies (HP:0100314)4.02593894
9Alacrima (HP:0000522)3.97026431
10Abnormal auditory evoked potentials (HP:0006958)3.90591405
11Febrile seizures (HP:0002373)3.90547478
12Intention tremor (HP:0002080)3.87203859
13Epileptic encephalopathy (HP:0200134)3.69367728
14Obstructive sleep apnea (HP:0002870)3.66201728
15Supranuclear gaze palsy (HP:0000605)3.64480434
16Dysmetria (HP:0001310)3.63560328
17Onion bulb formation (HP:0003383)3.63541554
18Bundle branch block (HP:0011710)3.57188145
19Visual hallucinations (HP:0002367)3.55762410
20Sensory axonal neuropathy (HP:0003390)3.48295962
21Spastic gait (HP:0002064)3.45105809
22Focal motor seizures (HP:0011153)3.35826320
23Ankle clonus (HP:0011448)3.32276932
24Abnormal eating behavior (HP:0100738)3.28629332
25Annular pancreas (HP:0001734)3.21354272
26Generalized tonic-clonic seizures (HP:0002069)3.15565991
27CNS hypomyelination (HP:0003429)3.12947248
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.12932798
29Papilledema (HP:0001085)3.12670166
30Decreased lacrimation (HP:0000633)3.04667199
31Muscle fiber splitting (HP:0003555)3.03469255
32Scanning speech (HP:0002168)3.02560585
33Action tremor (HP:0002345)2.98490226
34Hemiplegia (HP:0002301)2.92100369
35Morphological abnormality of the inner ear (HP:0011390)2.90342812
36Tetraplegia (HP:0002445)2.88554020
37Sudden death (HP:0001699)2.86023427
38Truncal ataxia (HP:0002078)2.76290364
39Heart block (HP:0012722)2.76154027
40Ventricular fibrillation (HP:0001663)2.74410605
41Choroideremia (HP:0001139)2.72025347
42Progressive cerebellar ataxia (HP:0002073)2.69780144
43Aplasia involving bones of the upper limbs (HP:0009823)2.64519329
44Aplasia of the phalanges of the hand (HP:0009802)2.64519329
45Aplasia involving bones of the extremities (HP:0009825)2.64519329
46Megalencephaly (HP:0001355)2.63973519
47Leukodystrophy (HP:0002415)2.63813456
48Abnormal atrioventricular conduction (HP:0005150)2.59852753
49Depression (HP:0000716)2.59360326
50Hypoplasia of the iris (HP:0007676)2.57534828
51Metabolic alkalosis (HP:0200114)2.57365963
52Choreoathetosis (HP:0001266)2.56776066
53Focal dystonia (HP:0004373)2.55029074
54Delusions (HP:0000746)2.54577589
55Abnormality of binocular vision (HP:0011514)2.53237714
56Diplopia (HP:0000651)2.53237714
57Slow saccadic eye movements (HP:0000514)2.52384765
58Increased circulating renin level (HP:0000848)2.51365208
59Anxiety (HP:0000739)2.50630420
60Pheochromocytoma (HP:0002666)2.48740295
61Absence seizures (HP:0002121)2.48065895
62Clumsiness (HP:0002312)2.45934723
63Sleep apnea (HP:0010535)2.44359819
64Hyporeflexia of lower limbs (HP:0002600)2.42812623
65Spastic tetraparesis (HP:0001285)2.42390931
66Postural instability (HP:0002172)2.42226647
67Focal seizures (HP:0007359)2.41132542
68Akinesia (HP:0002304)2.40990639
69White forelock (HP:0002211)2.40638854
70Atrioventricular block (HP:0001678)2.40591142
71Craniofacial dystonia (HP:0012179)2.38338173
72Split foot (HP:0001839)2.36617891
73Foot dorsiflexor weakness (HP:0009027)2.36027535
74Axonal loss (HP:0003447)2.34900966
75Glomerulonephritis (HP:0000099)2.33821770
76Broad-based gait (HP:0002136)2.33677762
77Rapidly progressive (HP:0003678)2.33326744
78Parakeratosis (HP:0001036)2.30539595
79Syncope (HP:0001279)2.29910909
80Bradykinesia (HP:0002067)2.29231483
81Anteriorly placed anus (HP:0001545)2.29198629
82Limb dystonia (HP:0002451)2.28777584
83Dialeptic seizures (HP:0011146)2.27666648
84Lower limb muscle weakness (HP:0007340)2.26923147
85Dysdiadochokinesis (HP:0002075)2.25957495
86Hypokalemic alkalosis (HP:0001949)2.25415844
87Coronal craniosynostosis (HP:0004440)2.22956339
88Insomnia (HP:0100785)2.22577129
89Thickened helices (HP:0000391)2.21299630
90Blue irides (HP:0000635)2.20784679
91Abnormality of aromatic amino acid family metabolism (HP:0004338)2.20262484
92Urinary urgency (HP:0000012)2.20049405
93Atonic seizures (HP:0010819)2.18992228
94Spastic paraparesis (HP:0002313)2.17124761
95Abnormality of the foot musculature (HP:0001436)2.16182226
96Partial duplication of the phalanx of hand (HP:0009999)2.16038729
97Status epilepticus (HP:0002133)2.15507158
98Impaired vibration sensation in the lower limbs (HP:0002166)2.15302717
99Cerebral hemorrhage (HP:0001342)2.14644723
100Atrial fibrillation (HP:0005110)2.13471051
101Termporal pattern (HP:0011008)2.13191126
102Insidious onset (HP:0003587)2.13191126
103Abnormality of the salivary glands (HP:0010286)2.13024766
104Poor speech (HP:0002465)2.12730820
105Neuroendocrine neoplasm (HP:0100634)2.12354974
106Apathy (HP:0000741)2.12093672
107Hemiparesis (HP:0001269)2.11757421
108Primary atrial arrhythmia (HP:0001692)2.11127093
109Patchy hypopigmentation of hair (HP:0011365)2.09997655
110Neuronal loss in central nervous system (HP:0002529)2.09761947
111Poor eye contact (HP:0000817)2.09671288
112Abnormality of the periventricular white matter (HP:0002518)2.09516848
113Absent septum pellucidum (HP:0001331)2.06873129
114Lower limb amyotrophy (HP:0007210)2.06343459
115Rigidity (HP:0002063)2.06031672
116Prolonged QT interval (HP:0001657)2.05680971
117Ventricular arrhythmia (HP:0004308)2.05459328
118Premature skin wrinkling (HP:0100678)2.05107029
119Progressive neurologic deterioration (HP:0002344)2.04876072
120Segmental peripheral demyelination/remyelination (HP:0003481)2.03457331
121Supraventricular tachycardia (HP:0004755)2.03021684
122Clonus (HP:0002169)2.02693455
123Infantile muscular hypotonia (HP:0008947)2.02691937
124Gaze-evoked nystagmus (HP:0000640)2.02608474
125Turricephaly (HP:0000262)2.01971262
126Paraparesis (HP:0002385)2.00634336
127Bronchomalacia (HP:0002780)2.00230604
128Abnormal EKG (HP:0003115)1.97590465
129Humeroradial synostosis (HP:0003041)1.96697997
130Synostosis involving the elbow (HP:0003938)1.96697997
131Supraventricular arrhythmia (HP:0005115)1.96466874
132Abnormality of the lower motor neuron (HP:0002366)1.95529314
133Mutism (HP:0002300)1.91686484
134Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91394022
135Progressive inability to walk (HP:0002505)1.90624916
136Septo-optic dysplasia (HP:0100842)1.88623972
137Diminished motivation (HP:0000745)1.88430463
138Slow progression (HP:0003677)1.87505163
139Spinal canal stenosis (HP:0003416)1.87490470
140Confusion (HP:0001289)1.87094465
141Gowers sign (HP:0003391)1.85199821
142Bowel incontinence (HP:0002607)1.85147328
143Torticollis (HP:0000473)1.84670906
144Stereotypic behavior (HP:0000733)1.83341517
145Peripheral demyelination (HP:0011096)1.83231760
146Exercise-induced myalgia (HP:0003738)1.82989955
147Abnormality of saccadic eye movements (HP:0000570)1.80573531
148Stridor (HP:0010307)1.80408444
149Urinary bladder sphincter dysfunction (HP:0002839)1.80316948
150Hypomagnesemia (HP:0002917)1.79818706
151Broad metatarsal (HP:0001783)1.78244047
152Morphological abnormality of the pyramidal tract (HP:0002062)1.77830332
153Partial duplication of thumb phalanx (HP:0009944)1.76386148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.82032381
2OXSR13.93771656
3PKN13.08325468
4FGFR22.47150233
5RIPK12.46391421
6CDK192.28897879
7PRPF4B2.21254313
8CAMK2B2.18403317
9BCR2.18365236
10LIMK12.16229341
11CAMKK12.15974364
12CSNK1A1L2.01918748
13CSNK1G32.01035624
14WNK11.93394167
15PAK61.92516143
16CAMK2D1.88272653
17ROCK21.86061714
18TRPM71.86009567
19NEK61.82764643
20NTRK11.79117740
21UHMK11.77557980
22ARAF1.76347683
23PHKG21.76298562
24PHKG11.76298562
25RIPK41.75906335
26MET1.74166907
27CSNK1G21.71741670
28CAMK2G1.66490432
29WNK41.66057952
30MARK11.65285522
31CSNK1G11.63986644
32NTRK31.47164378
33TNIK1.43276752
34TESK21.42992527
35PRKCH1.42547541
36PNCK1.35744995
37SGK4941.34215593
38SGK2231.34215593
39EPHA41.27018986
40LATS21.25979990
41EPHB11.22544811
42MAPKAPK51.21712999
43NTRK21.19528364
44CASK1.19235094
45MUSK1.18966397
46CDK51.15859036
47CAMK2A1.13831174
48PBK1.09612719
49DAPK11.03512114
50TYRO31.00037393
51PDPK10.98890631
52DAPK20.97824028
53SGK20.94840582
54STK380.93720902
55PRKD30.93582829
56FGR0.92348305
57MARK20.91903808
58PAK30.89935665
59PIK3CA0.89723173
60ICK0.89483926
61CDK140.88915142
62PRKD10.88879357
63TNK20.84511122
64SGK30.84263473
65MYLK0.81716824
66DAPK30.81166715
67MAP3K110.81138377
68KSR20.81009708
69CDK150.80478094
70DMPK0.79779754
71SIK20.79038561
72DYRK1A0.78268040
73MAP3K90.76358163
74CDK180.74671646
75CLK10.72468542
76PDK10.71560640
77PRKCE0.70818724
78STK110.70638096
79TESK10.70208967
80MINK10.69684244
81CDK11A0.68748821
82DYRK20.66572223
83MAPK130.65898166
84PRKCQ0.63692132
85CAMK40.63080188
86FYN0.62897122
87LMTK20.61565263
88PRKG20.61023020
89FES0.60613978
90PRKG10.60079689
91RET0.59338753
92MAP3K10.58208828
93RPS6KA30.58018081
94MAP3K130.55784135
95BMPR20.53915557
96PINK10.53508393
97MAPK40.53470799
98ROCK10.53419176
99PRKCG0.52697192
100MOS0.51005144
101CSNK1D0.49073032
102BMX0.48857793
103BRSK10.48569724
104CSNK1A10.48446354
105BRAF0.48439526
106TTN0.48336886
107PTK2B0.47930292
108TRIB30.47811906
109PDK20.46621283
110PRKACB0.46157019
111SGK10.45540850
112MST40.44987402
113CAMK1G0.44941433
114IRAK20.42357217
115PLK20.42137554
116CAMKK20.41253037
117ALK0.40839739
118PRKCZ0.40137693
119GRK50.39970859
120DDR20.38530526
121PRKACA0.38494901
122PRKCA0.37963697
123OBSCN0.37454920
124JAK10.37218116
125MAP3K20.37013090
126MAPK70.36875846
127PDGFRA0.36780495
128ITK0.36724092
129GSK3A0.36625266
130MAP3K70.36322844
131MAPK100.36110392
132JAK20.35452332
133ILK0.34410618
134CAMK10.34351108
135RAF10.34249291
136MAPK120.34015443
137MAP2K10.33051636
138SRC0.31809887

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.49539203
2Fatty acid elongation_Homo sapiens_hsa000622.41173341
3GABAergic synapse_Homo sapiens_hsa047272.28113588
4Glutamatergic synapse_Homo sapiens_hsa047242.15934851
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10793969
6Vitamin B6 metabolism_Homo sapiens_hsa007502.09144270
7Nicotine addiction_Homo sapiens_hsa050332.08166786
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07106203
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02228528
10Salivary secretion_Homo sapiens_hsa049701.78614156
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77334444
12Morphine addiction_Homo sapiens_hsa050321.76930092
13Synaptic vesicle cycle_Homo sapiens_hsa047211.73655266
14Axon guidance_Homo sapiens_hsa043601.69679232
15Gastric acid secretion_Homo sapiens_hsa049711.68647586
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63526723
17Circadian entrainment_Homo sapiens_hsa047131.62438531
18Ether lipid metabolism_Homo sapiens_hsa005651.51112914
19Oxidative phosphorylation_Homo sapiens_hsa001901.47645108
20Cardiac muscle contraction_Homo sapiens_hsa042601.46880487
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44435887
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40577668
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36739553
24Steroid biosynthesis_Homo sapiens_hsa001001.34847674
25Sulfur metabolism_Homo sapiens_hsa009201.34759412
26Cocaine addiction_Homo sapiens_hsa050301.33643110
27Long-term depression_Homo sapiens_hsa047301.26970729
28Serotonergic synapse_Homo sapiens_hsa047261.26027555
29Amphetamine addiction_Homo sapiens_hsa050311.25722057
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24405088
31Long-term potentiation_Homo sapiens_hsa047201.22801369
32Alzheimers disease_Homo sapiens_hsa050101.20127798
33Taste transduction_Homo sapiens_hsa047421.18311029
34Collecting duct acid secretion_Homo sapiens_hsa049661.18134314
35Histidine metabolism_Homo sapiens_hsa003401.16308770
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.13645201
37Insulin secretion_Homo sapiens_hsa049111.13619876
38Olfactory transduction_Homo sapiens_hsa047401.13583850
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13406693
40Estrogen signaling pathway_Homo sapiens_hsa049151.11074203
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11032571
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09753057
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06219603
44Folate biosynthesis_Homo sapiens_hsa007901.04369429
45Pancreatic secretion_Homo sapiens_hsa049721.02820591
46Sphingolipid metabolism_Homo sapiens_hsa006001.02659286
47Vibrio cholerae infection_Homo sapiens_hsa051101.02511451
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02457497
49Cholinergic synapse_Homo sapiens_hsa047250.98251990
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98141214
51Glioma_Homo sapiens_hsa052140.96266767
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96221458
53Renin secretion_Homo sapiens_hsa049240.95599850
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.95267691
55Dopaminergic synapse_Homo sapiens_hsa047280.94741451
56Parkinsons disease_Homo sapiens_hsa050120.93235804
57Arginine and proline metabolism_Homo sapiens_hsa003300.92391460
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92079229
59Calcium signaling pathway_Homo sapiens_hsa040200.89448729
60cAMP signaling pathway_Homo sapiens_hsa040240.85110381
61Bile secretion_Homo sapiens_hsa049760.82949794
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82750664
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.82434546
64Mineral absorption_Homo sapiens_hsa049780.81075534
65Tight junction_Homo sapiens_hsa045300.79996239
66Gap junction_Homo sapiens_hsa045400.79852768
67Circadian rhythm_Homo sapiens_hsa047100.79729877
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79680539
69Linoleic acid metabolism_Homo sapiens_hsa005910.79055033
70Dilated cardiomyopathy_Homo sapiens_hsa054140.77981430
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76417248
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76262919
73beta-Alanine metabolism_Homo sapiens_hsa004100.74379047
74Lysosome_Homo sapiens_hsa041420.73889470
75Butanoate metabolism_Homo sapiens_hsa006500.73390537
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72304383
77Rap1 signaling pathway_Homo sapiens_hsa040150.71801350
78Oxytocin signaling pathway_Homo sapiens_hsa049210.71427000
79Inositol phosphate metabolism_Homo sapiens_hsa005620.71376948
80Phototransduction_Homo sapiens_hsa047440.70834850
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69658905
82Melanogenesis_Homo sapiens_hsa049160.68865649
83Renal cell carcinoma_Homo sapiens_hsa052110.67962918
84VEGF signaling pathway_Homo sapiens_hsa043700.66486939
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.65760076
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62800050
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.61511965
88Ras signaling pathway_Homo sapiens_hsa040140.60574005
89Dorso-ventral axis formation_Homo sapiens_hsa043200.60549244
90Fatty acid metabolism_Homo sapiens_hsa012120.59780133
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59688160
92Hedgehog signaling pathway_Homo sapiens_hsa043400.57488772
93Ovarian steroidogenesis_Homo sapiens_hsa049130.57481500
94ErbB signaling pathway_Homo sapiens_hsa040120.57420283
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57207210
96Glucagon signaling pathway_Homo sapiens_hsa049220.57165666
97Thyroid hormone synthesis_Homo sapiens_hsa049180.56926409
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56731059
99Fatty acid biosynthesis_Homo sapiens_hsa000610.56107425
100Prion diseases_Homo sapiens_hsa050200.55472843
101Endocytosis_Homo sapiens_hsa041440.54035679
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53865889
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53078971
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52964220
105Choline metabolism in cancer_Homo sapiens_hsa052310.51869202
106Tyrosine metabolism_Homo sapiens_hsa003500.48501298
107Type II diabetes mellitus_Homo sapiens_hsa049300.47368853
108Oocyte meiosis_Homo sapiens_hsa041140.46811977
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.46202943
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45804796
111Protein digestion and absorption_Homo sapiens_hsa049740.45060735
112Rheumatoid arthritis_Homo sapiens_hsa053230.44934009
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41252355
114GnRH signaling pathway_Homo sapiens_hsa049120.41036312
115Arginine biosynthesis_Homo sapiens_hsa002200.40707898
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39632568
117PPAR signaling pathway_Homo sapiens_hsa033200.39096694
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39069596
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39000195
120Propanoate metabolism_Homo sapiens_hsa006400.38407993
121Amoebiasis_Homo sapiens_hsa051460.36775867
122Glutathione metabolism_Homo sapiens_hsa004800.35456458
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34850283
124MAPK signaling pathway_Homo sapiens_hsa040100.34659427
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34507053
126Insulin signaling pathway_Homo sapiens_hsa049100.32437876
127HIF-1 signaling pathway_Homo sapiens_hsa040660.28670313
128AMPK signaling pathway_Homo sapiens_hsa041520.28657083
129Phenylalanine metabolism_Homo sapiens_hsa003600.27842994

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