PTGER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.42619591
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.13902959
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.13902959
4leukocyte aggregation (GO:0070486)4.67018644
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64635186
6antigen processing and presentation of endogenous antigen (GO:0019883)4.60120523
7tolerance induction (GO:0002507)4.51056944
8neutrophil activation involved in immune response (GO:0002283)4.28265743
9regulation of B cell receptor signaling pathway (GO:0050855)4.13356872
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.11728429
11regulation of interleukin-12 biosynthetic process (GO:0045075)4.04108877
12response to interleukin-15 (GO:0070672)4.02990720
13interferon-gamma production (GO:0032609)4.00216943
14regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.99995148
15regulation of gamma-delta T cell activation (GO:0046643)3.98833550
16regulation of gamma-delta T cell differentiation (GO:0045586)3.98427677
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.96643701
18negative regulation of cell killing (GO:0031342)3.96643701
19modulation by symbiont of host immune response (GO:0052553)3.96117851
20positive regulation by symbiont of host defense response (GO:0052509)3.96117851
21modulation by symbiont of host defense response (GO:0052031)3.96117851
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96117851
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96117851
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.96117851
25regulation of T cell tolerance induction (GO:0002664)3.76881525
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.76031391
27negative thymic T cell selection (GO:0045060)3.75320944
28negative T cell selection (GO:0043383)3.74191853
29response to peptidoglycan (GO:0032494)3.70283665
30immunoglobulin mediated immune response (GO:0016064)3.67487674
31regulation of tolerance induction (GO:0002643)3.60450813
32negative regulation of interleukin-12 production (GO:0032695)3.59421907
33positive regulation of tolerance induction (GO:0002645)3.58243650
34negative regulation of T cell mediated immunity (GO:0002710)3.56331988
35response to protozoan (GO:0001562)3.55899347
36regulation of alpha-beta T cell proliferation (GO:0046640)3.53250033
37respiratory burst (GO:0045730)3.53096234
38negative regulation of erythrocyte differentiation (GO:0045647)3.51581962
39cellular response to interleukin-15 (GO:0071350)3.50228967
40defense response to protozoan (GO:0042832)3.46308501
41T cell migration (GO:0072678)3.45541233
42NIK/NF-kappaB signaling (GO:0038061)3.42621232
43positive thymic T cell selection (GO:0045059)3.42357256
44positive regulation of immunoglobulin mediated immune response (GO:0002891)3.36222361
45positive regulation of B cell mediated immunity (GO:0002714)3.36222361
46detection of other organism (GO:0098543)3.34366932
47lipopolysaccharide-mediated signaling pathway (GO:0031663)3.34197537
48positive regulation of isotype switching (GO:0045830)3.30544109
49positive regulation of alpha-beta T cell proliferation (GO:0046641)3.30487821
50myeloid dendritic cell activation (GO:0001773)3.30463196
51neutrophil mediated immunity (GO:0002446)3.25832135
52negative regulation of leukocyte mediated immunity (GO:0002704)3.25753377
53JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.25501972
54granulocyte activation (GO:0036230)3.23948745
55positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.23611129
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.22633008
57regulation of natural killer cell mediated immunity (GO:0002715)3.21876480
58regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.21876480
59neutrophil activation (GO:0042119)3.21708173
60regulation of interferon-beta biosynthetic process (GO:0045357)3.21431522
61regulation of isotype switching to IgG isotypes (GO:0048302)3.20857138
62regulation of interleukin-2 biosynthetic process (GO:0045076)3.19647493
63positive regulation of B cell differentiation (GO:0045579)3.17573465
64positive regulation of T cell mediated cytotoxicity (GO:0001916)3.17566375
65mast cell activation (GO:0045576)3.16078465
66positive regulation of interleukin-2 production (GO:0032743)3.15379369
67regulation of B cell differentiation (GO:0045577)3.15192296
68detection of bacterium (GO:0016045)3.15094604
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.14204142
70response to muramyl dipeptide (GO:0032495)3.13563763
71myeloid dendritic cell differentiation (GO:0043011)3.12430167
72positive regulation of humoral immune response (GO:0002922)3.12241850
73regulation of regulatory T cell differentiation (GO:0045589)3.11816748
74regulation of mast cell degranulation (GO:0043304)3.11263924
75negative regulation of cytokine production involved in immune response (GO:0002719)3.10855973
76modulation of growth of symbiont involved in interaction with host (GO:0044144)3.10376430
77regulation of growth of symbiont in host (GO:0044126)3.10376430
78negative regulation of growth of symbiont in host (GO:0044130)3.10376430
79negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.10376430
80regulation of T cell mediated cytotoxicity (GO:0001914)3.08276597
81myeloid cell activation involved in immune response (GO:0002275)3.08245924
82interferon-gamma-mediated signaling pathway (GO:0060333)3.07775506
83positive regulation of natural killer cell differentiation (GO:0032825)3.06459649
84leukocyte cell-cell adhesion (GO:0007159)3.05211884
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.03801210
86regulation of immunoglobulin secretion (GO:0051023)3.00559042
87positive regulation of interleukin-17 production (GO:0032740)2.98369875
88regulation of chemokine biosynthetic process (GO:0045073)2.97336355
89T cell proliferation (GO:0042098)2.94292261
90cellular extravasation (GO:0045123)2.93600251
91macrophage activation involved in immune response (GO:0002281)2.92914478
92activated T cell proliferation (GO:0050798)2.92346583
93regulation of immunoglobulin mediated immune response (GO:0002889)2.91925714
94regulation of chronic inflammatory response (GO:0002676)2.91681105
95lymphocyte chemotaxis (GO:0048247)2.91220831
96thymic T cell selection (GO:0045061)2.90645139
97negative regulation of phagocytosis (GO:0050765)2.90034676
98Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89890425
99regulation of B cell mediated immunity (GO:0002712)2.89341528
100positive regulation of cytokine biosynthetic process (GO:0042108)2.89294518
101positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.86107201
102positive regulation of T-helper 1 type immune response (GO:0002827)2.85661911
103regulation of interleukin-17 production (GO:0032660)2.85186471
104regulation of response to interferon-gamma (GO:0060330)2.84690871
105response to type I interferon (GO:0034340)2.84688834
106cellular response to type I interferon (GO:0071357)2.84258011
107type I interferon signaling pathway (GO:0060337)2.84258011
108regulation of leukocyte mediated cytotoxicity (GO:0001910)2.84184857
109regulation of mast cell activation involved in immune response (GO:0033006)2.83968550
110positive regulation of interferon-gamma production (GO:0032729)2.83416166
111lymphocyte migration (GO:0072676)2.83217932
112positive regulation of DNA recombination (GO:0045911)2.82804148
113dendritic cell chemotaxis (GO:0002407)2.82509657
114regulation of T cell receptor signaling pathway (GO:0050856)2.81426098
115B cell mediated immunity (GO:0019724)2.81249947
116positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.80190344
117T cell selection (GO:0045058)2.79767818
118negative regulation of interleukin-6 production (GO:0032715)2.79669099
119regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.79307078
120positive T cell selection (GO:0043368)2.79119122
121CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.78713679
122negative regulation of innate immune response (GO:0045824)2.78102889
123T cell costimulation (GO:0031295)2.77626864
124regulation of leukocyte degranulation (GO:0043300)2.76689506
125detection of external biotic stimulus (GO:0098581)2.76102675
126microglial cell activation (GO:0001774)2.75024607
127regulation of alpha-beta T cell activation (GO:0046634)2.74780689
128regulation of T-helper 1 cell differentiation (GO:0045625)2.74460555
129leukocyte degranulation (GO:0043299)2.74020571
130regulation of myeloid leukocyte mediated immunity (GO:0002886)2.73567915
131regulation of mast cell activation (GO:0033003)2.73415009
132positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.72546571
133negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.70825858
134positive regulation of natural killer cell mediated immunity (GO:0002717)2.70531787
135positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.67953240
136regulation of vitamin D biosynthetic process (GO:0060556)2.66434456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.18713927
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.67289158
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.02095760
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.60547639
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.30013329
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.55459696
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.51765821
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.40488998
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40126797
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.35734403
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.32344422
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.24700028
13* IRF8_27001747_Chip-Seq_BMDM_Mouse3.19596661
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18260711
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.16710373
16E2F7_22180533_ChIP-Seq_HELA_Human2.91131887
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64760204
18RUNX_20019798_ChIP-Seq_JUKART_Human2.64680773
19* MYB_26560356_Chip-Seq_TH2_Human2.62118169
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.54968246
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49416762
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46449307
23MAF_26560356_Chip-Seq_TH1_Human2.29536068
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28071745
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24766305
26SPI1_23547873_ChIP-Seq_NB4_Human2.21341005
27* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18740176
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18206292
29* MYB_26560356_Chip-Seq_TH1_Human2.14476488
30MYC_22102868_ChIP-Seq_BL_Human2.10939757
31SCL_19346495_ChIP-Seq_HPC-7_Human2.08229623
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05550290
33VDR_21846776_ChIP-Seq_THP-1_Human2.04660603
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02118101
35VDR_24763502_ChIP-Seq_THP-1_Human2.01446575
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.98086771
37* UTX_26944678_Chip-Seq_JUKART_Human1.84997994
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78461780
39* PU_27001747_Chip-Seq_BMDM_Mouse1.68248211
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.67889459
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64384696
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63896860
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58916593
44GATA3_27048872_Chip-Seq_THYMUS_Human1.55600784
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53671726
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49898860
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45545884
48TCF7_22412390_ChIP-Seq_EML_Mouse1.43770612
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.43223877
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40201008
51SPI1_23127762_ChIP-Seq_K562_Human1.38905142
52* MAF_26560356_Chip-Seq_TH2_Human1.36857790
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36757363
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28987856
55GATA3_26560356_Chip-Seq_TH2_Human1.27974373
56VDR_24787735_ChIP-Seq_THP-1_Human1.27376631
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25706871
58GATA1_19941826_ChIP-Seq_K562_Human1.25070458
59* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21696506
60CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21031616
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19378988
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18747077
63GATA1_22025678_ChIP-Seq_K562_Human1.18519312
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18078161
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16469648
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16434143
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15286788
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14837035
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13173748
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09809728
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08424977
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07691648
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03072059
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02600436
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01916695
76* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01910934
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01231413
78KDM2B_26808549_Chip-Seq_DND41_Human1.00866141
79BCL6_27268052_Chip-Seq_Bcells_Human1.00105191
80* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00030486
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99288684
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98538088
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98245739
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97213251
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.94112419
86CLOCK_20551151_ChIP-Seq_293T_Human0.94022216
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.93534199
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93379021
89GATA2_21666600_ChIP-Seq_HMVEC_Human0.90352420
90* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89597273
91BCOR_27268052_Chip-Seq_Bcells_Human0.88827098
92KDM2B_26808549_Chip-Seq_JURKAT_Human0.88596321
93* LXR_22292898_ChIP-Seq_THP-1_Human0.85974150
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85782146
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85481562
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84526511
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83004122
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81651854
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78518559
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77988713
101* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76175822
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75779685
103EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.74891684
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74765828
105EGR1_19032775_ChIP-ChIP_M12_Human0.74356310
106STAT1_20625510_ChIP-Seq_HELA_Human0.72665363
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.72600943
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72130760
109TFEB_21752829_ChIP-Seq_HELA_Human0.70859058
110NCOR1_26117541_ChIP-Seq_K562_Human0.70158955
111GATA2_19941826_ChIP-Seq_K562_Human0.68125730
112ELK1_19687146_ChIP-ChIP_HELA_Human0.67756629
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.66234886
114GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65506047
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.63473314
116VDR_23849224_ChIP-Seq_CD4+_Human0.63455996
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.62222965
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.62222965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.88872101
2MP0001835_abnormal_antigen_presentation3.81242787
3MP0003724_increased_susceptibility_to3.58424687
4MP0009785_altered_susceptibility_to3.54812734
5MP0005671_abnormal_response_to3.37507779
6MP0005000_abnormal_immune_tolerance3.13260702
7MP0003303_peritoneal_inflammation3.08616425
8MP0000685_abnormal_immune_system2.89469178
9* MP0002419_abnormal_innate_immunity2.84903776
10MP0002148_abnormal_hypersensitivity_rea2.84884730
11MP0001800_abnormal_humoral_immune2.78296182
12MP0005387_immune_system_phenotype2.76775911
13MP0001790_abnormal_immune_system2.76775911
14* MP0005025_abnormal_response_to2.76211660
15MP0003763_abnormal_thymus_physiology2.65458980
16MP0002723_abnormal_immune_serum2.60717423
17* MP0002452_abnormal_antigen_presenting2.55844512
18MP0002405_respiratory_system_inflammati2.51417726
19MP0003300_gastrointestinal_ulcer2.47752604
20* MP0002420_abnormal_adaptive_immunity2.44214318
21* MP0001819_abnormal_immune_cell2.42253315
22MP0006082_CNS_inflammation2.31022145
23MP0001853_heart_inflammation2.29072392
24MP0010155_abnormal_intestine_physiology2.17876924
25MP0009333_abnormal_splenocyte_physiolog2.17729382
26MP0001533_abnormal_skeleton_physiology2.04907930
27MP0002396_abnormal_hematopoietic_system2.03860325
28MP0002398_abnormal_bone_marrow2.01173466
29MP0004510_myositis1.97889481
30MP0001845_abnormal_inflammatory_respons1.97612675
31MP0005464_abnormal_platelet_physiology1.95121609
32* MP0000716_abnormal_immune_system1.92103015
33MP0002166_altered_tumor_susceptibility1.88709695
34MP0000465_gastrointestinal_hemorrhage1.87682538
35MP0002006_tumorigenesis1.84426303
36MP0004947_skin_inflammation1.77826481
37MP0000689_abnormal_spleen_morphology1.75766348
38MP0000343_altered_response_to1.74390310
39MP0002722_abnormal_immune_system1.68411288
40MP0003866_abnormal_defecation1.67545945
41MP0002933_joint_inflammation1.63265658
42MP0000858_altered_metastatic_potential1.62890242
43MP0005397_hematopoietic_system_phenotyp1.59120531
44MP0001545_abnormal_hematopoietic_system1.59120531
45MP0008469_abnormal_protein_level1.58599086
46* MP0002429_abnormal_blood_cell1.58153848
47MP0009764_decreased_sensitivity_to1.57770150
48MP0001873_stomach_inflammation1.55321602
49* MP0003448_altered_tumor_morphology1.55253575
50MP0009278_abnormal_bone_marrow1.47540767
51MP0000703_abnormal_thymus_morphology1.40698555
52MP0004808_abnormal_hematopoietic_stem1.38832036
53MP0001851_eye_inflammation1.35252603
54* MP0003075_altered_response_to1.31937941
55MP0005058_abnormal_lysosome_morphology1.28564620
56MP0008004_abnormal_stomach_pH1.28406464
57MP0005451_abnormal_body_composition1.28354914
58MP0002998_abnormal_bone_remodeling1.25601102
59MP0005166_decreased_susceptibility_to1.19783228
60MP0005310_abnormal_salivary_gland1.11081222
61MP0000490_abnormal_crypts_of1.08622305
62MP0009763_increased_sensitivity_to1.07851933
63MP0003828_pulmonary_edema1.07790616
64* MP0005164_abnormal_response_to1.07674570
65MP0001881_abnormal_mammary_gland1.05692896
66MP0003806_abnormal_nucleotide_metabolis1.05435156
67MP0006054_spinal_hemorrhage1.04387898
68MP0005390_skeleton_phenotype1.01171632
69MP0004883_abnormal_blood_vessel1.00317338
70MP0003191_abnormal_cellular_cholesterol0.99699255
71MP0005023_abnormal_wound_healing0.99680385
72MP0003172_abnormal_lysosome_physiology0.97815170
73MP0008260_abnormal_autophagy0.95534622
74MP0002132_abnormal_respiratory_system0.94874034
75* MP0003690_abnormal_glial_cell0.92276189
76MP0000249_abnormal_blood_vessel0.91817162
77MP0005076_abnormal_cell_differentiation0.91077018
78MP0002009_preneoplasia0.87345145
79MP0002277_abnormal_respiratory_mucosa0.86148562
80MP0004782_abnormal_surfactant_physiolog0.85805416
81MP0001542_abnormal_bone_strength0.84182634
82MP0005174_abnormal_tail_pigmentation0.81149192
83MP0010368_abnormal_lymphatic_system0.80277827
84MP0003656_abnormal_erythrocyte_physiolo0.79486709
85* MP0000604_amyloidosis0.77628012
86MP0003183_abnormal_peptide_metabolism0.77559658
87MP0008873_increased_physiological_sensi0.76431597
88MP0005167_abnormal_blood-brain_barrier0.76072826
89MP0002138_abnormal_hepatobiliary_system0.75984609
90MP0000609_abnormal_liver_physiology0.75424720
91MP0009840_abnormal_foam_cell0.75361341
92* MP0002019_abnormal_tumor_incidence0.74846475
93* MP0003795_abnormal_bone_structure0.73002468
94MP0003186_abnormal_redox_activity0.71610178
95MP0010307_abnormal_tumor_latency0.69213951
96MP0003279_aneurysm0.69114370
97MP0009765_abnormal_xenobiotic_induced0.68645729
98MP0002254_reproductive_system_inflammat0.67549327
99MP0003045_fibrosis0.67042747
100MP0001663_abnormal_digestive_system0.66860840
101MP0001879_abnormal_lymphatic_vessel0.65007539
102MP0008874_decreased_physiological_sensi0.63359748
103MP0002332_abnormal_exercise_endurance0.61258492
104MP0010352_gastrointestinal_tract_polyps0.60823692
105MP0002136_abnormal_kidney_physiology0.60327595
106MP0004130_abnormal_muscle_cell0.58466440
107MP0001501_abnormal_sleep_pattern0.55655864
108MP0001243_abnormal_dermal_layer0.55134010
109MP0000920_abnormal_myelination0.55090741
110MP0002877_abnormal_melanocyte_morpholog0.53184688
111MP0003091_abnormal_cell_migration0.52586054
112MP0000598_abnormal_liver_morphology0.51714904
113* MP0005165_increased_susceptibility_to0.50024017
114MP0003453_abnormal_keratinocyte_physiol0.50021013
115MP0005075_abnormal_melanosome_morpholog0.48530120
116MP0005319_abnormal_enzyme/_coenzyme0.48224136

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.27739421
2Myositis (HP:0100614)6.20758465
3Recurrent abscess formation (HP:0002722)5.74170766
4Elevated erythrocyte sedimentation rate (HP:0003565)5.54591614
5Retrobulbar optic neuritis (HP:0100654)5.42942132
6Optic neuritis (HP:0100653)5.42942132
7Orchitis (HP:0100796)5.40596077
8Recurrent bacterial skin infections (HP:0005406)5.01116666
9Stomatitis (HP:0010280)4.98305123
10Recurrent gram-negative bacterial infections (HP:0005420)4.43399530
11Mediastinal lymphadenopathy (HP:0100721)4.32725220
12Recurrent fungal infections (HP:0002841)4.09748082
13Abnormality of macrophages (HP:0004311)4.07670257
14Keratoconjunctivitis sicca (HP:0001097)4.00208972
15IgM deficiency (HP:0002850)3.77309471
16Pulmonary infiltrates (HP:0002113)3.77286045
17Chronic obstructive pulmonary disease (HP:0006510)3.71710405
18Obstructive lung disease (HP:0006536)3.71710405
19Keratoconjunctivitis (HP:0001096)3.66883261
20Vasculitis (HP:0002633)3.62304741
21T lymphocytopenia (HP:0005403)3.51403231
22Abnormality of liposaccharide metabolism (HP:0010968)3.49261820
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.49261820
24Abnormality of glycolipid metabolism (HP:0010969)3.49261820
25Recurrent viral infections (HP:0004429)3.45812022
26Abnormality of T cell number (HP:0011839)3.45562351
27Recurrent skin infections (HP:0001581)3.37603311
28Autoimmune hemolytic anemia (HP:0001890)3.36392991
29Chronic otitis media (HP:0000389)3.35567879
30Gingivitis (HP:0000230)3.33581867
31Hemoptysis (HP:0002105)3.27600255
32Interstitial pulmonary disease (HP:0006530)3.25398374
33Arterial thrombosis (HP:0004420)3.24218660
34Abnormality of T cells (HP:0002843)3.23303058
35Pustule (HP:0200039)3.22502223
36Meningitis (HP:0001287)3.20679931
37Gastrointestinal infarctions (HP:0005244)3.11604947
38Periodontitis (HP:0000704)3.08264267
39Spontaneous hematomas (HP:0007420)3.07567357
40Thrombocytosis (HP:0001894)3.05369487
41Recurrent bronchitis (HP:0002837)3.01756126
42Dysostosis multiplex (HP:0000943)2.95754582
43Systemic lupus erythematosus (HP:0002725)2.95069880
44Petechiae (HP:0000967)2.86236347
45Increased IgE level (HP:0003212)2.85895030
46Leukocytosis (HP:0001974)2.85195579
47Joint swelling (HP:0001386)2.79596553
48Anorexia (HP:0002039)2.79196591
49Abnormality of T cell physiology (HP:0011840)2.79178500
50Recurrent cutaneous fungal infections (HP:0011370)2.78573610
51Chronic mucocutaneous candidiasis (HP:0002728)2.78573610
52Increased serum ferritin (HP:0003281)2.75913083
53Gangrene (HP:0100758)2.71540094
54Increased cerebral lipofuscin (HP:0011813)2.70785471
55IgA deficiency (HP:0002720)2.67304153
56Vacuolated lymphocytes (HP:0001922)2.66188793
57Nasal polyposis (HP:0100582)2.63471490
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.61768587
59Amyloidosis (HP:0011034)2.61765238
60Autoimmune thrombocytopenia (HP:0001973)2.61543911
61Episodic fever (HP:0001954)2.61507324
62Abnormality of the prostate (HP:0008775)2.61206635
63Hematochezia (HP:0002573)2.58801685
64Increased IgM level (HP:0003496)2.57677673
65Pulmonary embolism (HP:0002204)2.57096711
66Abnormality of the pleura (HP:0002103)2.56826348
67Eosinophilia (HP:0001880)2.55735484
68Abnormality of eosinophils (HP:0001879)2.55217067
69Loss of speech (HP:0002371)2.49190415
70Abnormality of iron homeostasis (HP:0011031)2.48858709
71IgG deficiency (HP:0004315)2.48364981
72Encephalitis (HP:0002383)2.48260973
73Hypergammaglobulinemia (HP:0010702)2.46938271
74Gingival bleeding (HP:0000225)2.46928268
75Increased density of long bones (HP:0006392)2.44796997
76Prostate neoplasm (HP:0100787)2.44396701
77Abnormality of the nasal mucosa (HP:0000433)2.43701749
78Chronic diarrhea (HP:0002028)2.43674419
79Cheilitis (HP:0100825)2.42996588
80Colitis (HP:0002583)2.39768037
81Severe combined immunodeficiency (HP:0004430)2.36349750
82Abnormality of B cell number (HP:0010975)2.35303514
83Combined immunodeficiency (HP:0005387)2.35135397
84Abnormal delayed hypersensitivity skin test (HP:0002963)2.35103275
85Hepatosplenomegaly (HP:0001433)2.35093277
86Urticaria (HP:0001025)2.34454908
87Granulocytopenia (HP:0001913)2.33994894
88Epistaxis (HP:0000421)2.32091883
89Osteomyelitis (HP:0002754)2.30560019
90Cellulitis (HP:0100658)2.30456024
91Persistence of primary teeth (HP:0006335)2.27430263
92Lymphopenia (HP:0001888)2.26836913
93Abnormality of the pericardium (HP:0001697)2.25694075
94Skin ulcer (HP:0200042)2.23304438
95Inflammation of the large intestine (HP:0002037)2.22704449
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.21747167
97Basal ganglia calcification (HP:0002135)2.21052971
98Glomerulopathy (HP:0100820)2.20567035
99Panhypogammaglobulinemia (HP:0003139)2.16955135
100Hypertensive crisis (HP:0100735)2.15745640
101Gastrointestinal stroma tumor (HP:0100723)2.15675015
102Chest pain (HP:0100749)2.15418882
103Vertigo (HP:0002321)2.14191655
104Polyneuropathy (HP:0001271)2.13933110
105Joint hemorrhage (HP:0005261)2.13525379
106Arthralgia (HP:0002829)2.11305243
107Agammaglobulinemia (HP:0004432)2.08793278
108Acne (HP:0001061)2.08748836
109Gastrointestinal inflammation (HP:0004386)2.07668146
110Keratitis (HP:0000491)2.07331616
111Myocardial infarction (HP:0001658)2.07287771
112Amaurosis fugax (HP:0100576)2.05518443
113Nonimmune hydrops fetalis (HP:0001790)2.03916073
114Lymphoma (HP:0002665)2.03645011
115B lymphocytopenia (HP:0010976)2.03608407
116Abnormality of transition element cation homeostasis (HP:0011030)2.03176303
117Abnormal platelet volume (HP:0011876)2.00816716
118Prolonged bleeding time (HP:0003010)2.00643049
119Purpura (HP:0000979)1.98694202
120Thrombophlebitis (HP:0004418)1.97332681
121Glomerulonephritis (HP:0000099)1.96177594
122Peritonitis (HP:0002586)1.96159130
123Aplastic anemia (HP:0001915)1.94159291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.81861286
2MAP4K14.50659235
3MAP3K143.14661144
4TESK23.14485165
5JAK33.09307622
6ZAP702.69884284
7TBK12.62077075
8TYK22.61991166
9TEC2.52633981
10PRPF4B2.51793977
11IRAK42.48297332
12ITK2.46789319
13KIT2.36628982
14BLK2.31002162
15IKBKE2.24252682
16IRAK32.23225597
17RIPK42.19942290
18JAK12.07144572
19GRK71.98835924
20BTK1.96499111
21STK101.84346327
22EPHB11.83832513
23IKBKB1.76685224
24TAOK31.68879572
25KDR1.66049940
26CSK1.62625139
27ERN11.62500769
28SYK1.55599619
29MAP2K31.53697912
30FGFR41.51785437
31LCK1.51754425
32FES1.44559616
33HCK1.44468098
34PIM21.44342349
35BMPR21.43155013
36CLK11.37046434
37NME21.36965291
38RPS6KA41.36912677
39PIM11.23432316
40MST41.22674356
41JAK21.22557950
42CHUK1.17996690
43TGFBR21.16909248
44FGFR31.15907558
45LYN1.14065915
46GRK61.07971797
47MUSK1.06228613
48FLT31.02515984
49EPHA31.00465183
50TRPM70.96608396
51LRRK20.96063208
52MOS0.95061101
53NEK90.93739563
54EEF2K0.91927969
55NLK0.90046602
56CSF1R0.88982064
57PRKD20.86607327
58MAP3K130.82240480
59CDC42BPA0.81622275
60TNK20.78112555
61CAMKK20.78055724
62IRAK20.75464744
63MAP3K30.72694368
64IRAK10.69450213
65RAF10.69053968
66MAP3K110.68143405
67MAPK70.68102023
68MARK30.67400703
69PRKCQ0.67291544
70SCYL20.64416966
71MAP2K20.64312472
72PIK3CG0.62062612
73PTK60.59571648
74CDK60.59543320
75PKN20.56895060
76RPS6KA60.56458596
77MAPK40.54732946
78SIK30.54334324
79TAOK10.52750030
80PDGFRB0.52635269
81TRIB30.50018862
82ABL10.49597678
83MAP2K60.48122122
84NUAK10.48045711
85MAP3K60.47704856
86TGFBR10.47363262
87CAMKK10.47212116
88MATK0.46379119
89DDR20.45735625
90CDK40.45605928
91TAOK20.44123058
92RIPK10.44078183
93PRKCH0.43729455
94RPS6KC10.43436273
95RPS6KL10.43436273
96ALK0.43332818
97PRKCD0.42033579
98MAPK110.41774750
99SIK20.41482525
100MAPKAPK20.41207084
101FGR0.41025838
102EGFR0.40629581
103MAP3K120.40570226
104MAP3K50.39005538
105MAPK120.38583306
106HIPK20.36341015
107DYRK1B0.35710900
108ABL20.35057278
109FYN0.34843642
110PDPK10.33197478
111IGF1R0.32019673
112MAP3K10.31003020
113BCKDK0.30205284
114ADRBK20.28474258
115CDK90.27888259
116MAP3K70.26224571
117TTN0.26080911
118TSSK60.25372782
119PDK10.22656338
120TESK10.22047064
121MAPK30.21953211
122YES10.20296444
123STK40.19949838
124INSR0.19382133
125CAMK40.19264171

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.53904204
2Leishmaniasis_Homo sapiens_hsa051403.30553343
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.90295056
4Primary immunodeficiency_Homo sapiens_hsa053402.69591843
5Graft-versus-host disease_Homo sapiens_hsa053322.66346798
6Staphylococcus aureus infection_Homo sapiens_hsa051502.53013147
7Allograft rejection_Homo sapiens_hsa053302.51742730
8Osteoclast differentiation_Homo sapiens_hsa043802.51211066
9Measles_Homo sapiens_hsa051622.50511967
10Legionellosis_Homo sapiens_hsa051342.42054491
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.34444998
12T cell receptor signaling pathway_Homo sapiens_hsa046602.22852668
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.21867696
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08901412
15Hematopoietic cell lineage_Homo sapiens_hsa046402.07427729
16Malaria_Homo sapiens_hsa051442.07017801
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01065683
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00371625
19Pertussis_Homo sapiens_hsa051332.00299901
20TNF signaling pathway_Homo sapiens_hsa046681.93695424
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88331184
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.86586793
23Antigen processing and presentation_Homo sapiens_hsa046121.82508319
24Asthma_Homo sapiens_hsa053101.80563497
25Tuberculosis_Homo sapiens_hsa051521.75128692
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.73256140
27Rheumatoid arthritis_Homo sapiens_hsa053231.70551395
28Toxoplasmosis_Homo sapiens_hsa051451.70139656
29B cell receptor signaling pathway_Homo sapiens_hsa046621.68831211
30Type I diabetes mellitus_Homo sapiens_hsa049401.57289473
31Herpes simplex infection_Homo sapiens_hsa051681.51131918
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49209464
33Influenza A_Homo sapiens_hsa051641.48598373
34Salmonella infection_Homo sapiens_hsa051321.39691557
35Chemokine signaling pathway_Homo sapiens_hsa040621.33222782
36Apoptosis_Homo sapiens_hsa042101.28342329
37Shigellosis_Homo sapiens_hsa051311.28059908
38Hepatitis B_Homo sapiens_hsa051611.27099011
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25393585
40Autoimmune thyroid disease_Homo sapiens_hsa053201.22462433
41Viral myocarditis_Homo sapiens_hsa054161.21375805
42African trypanosomiasis_Homo sapiens_hsa051431.21290876
43Acute myeloid leukemia_Homo sapiens_hsa052211.19101660
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14953322
45Phagosome_Homo sapiens_hsa041451.09162057
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08438747
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.07671840
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.01839090
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90355939
50Lysosome_Homo sapiens_hsa041420.89971224
51Prolactin signaling pathway_Homo sapiens_hsa049170.88947185
52Caffeine metabolism_Homo sapiens_hsa002320.87681195
53Other glycan degradation_Homo sapiens_hsa005110.87237807
54Chronic myeloid leukemia_Homo sapiens_hsa052200.81028374
55Hepatitis C_Homo sapiens_hsa051600.79895407
56Epstein-Barr virus infection_Homo sapiens_hsa051690.77912767
57Complement and coagulation cascades_Homo sapiens_hsa046100.76888987
58HTLV-I infection_Homo sapiens_hsa051660.76575685
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71693265
60Amoebiasis_Homo sapiens_hsa051460.71389319
61Pancreatic cancer_Homo sapiens_hsa052120.69754875
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64420594
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61628652
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.60524852
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59085594
66Platelet activation_Homo sapiens_hsa046110.58831405
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57699387
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56577034
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54430615
70Viral carcinogenesis_Homo sapiens_hsa052030.52927696
71Small cell lung cancer_Homo sapiens_hsa052220.46894755
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.46600631
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45903512
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42937550
75* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41715039
76VEGF signaling pathway_Homo sapiens_hsa043700.40774392
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37864441
78HIF-1 signaling pathway_Homo sapiens_hsa040660.36894389
79Base excision repair_Homo sapiens_hsa034100.34689102
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34535618
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34213142
82Insulin resistance_Homo sapiens_hsa049310.33849927
83p53 signaling pathway_Homo sapiens_hsa041150.32362789
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30412510
85DNA replication_Homo sapiens_hsa030300.30016709
86Bladder cancer_Homo sapiens_hsa052190.28276631
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28127673
88Type II diabetes mellitus_Homo sapiens_hsa049300.28070511
89Colorectal cancer_Homo sapiens_hsa052100.28064193
90Pentose phosphate pathway_Homo sapiens_hsa000300.27757688
91Non-small cell lung cancer_Homo sapiens_hsa052230.27645612
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.26269620
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25396284
94Notch signaling pathway_Homo sapiens_hsa043300.25119693
95Renal cell carcinoma_Homo sapiens_hsa052110.23890882
96Regulation of autophagy_Homo sapiens_hsa041400.23615336
97Ribosome_Homo sapiens_hsa030100.23098498
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.22638342
99FoxO signaling pathway_Homo sapiens_hsa040680.21469838
100mTOR signaling pathway_Homo sapiens_hsa041500.19021720
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18853060
102Endocytosis_Homo sapiens_hsa041440.18802611
103Systemic lupus erythematosus_Homo sapiens_hsa053220.17896792
104Starch and sucrose metabolism_Homo sapiens_hsa005000.17864139
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16824560
106Proteoglycans in cancer_Homo sapiens_hsa052050.16687228
107Arachidonic acid metabolism_Homo sapiens_hsa005900.16539451
108Prostate cancer_Homo sapiens_hsa052150.15974419
109MAPK signaling pathway_Homo sapiens_hsa040100.15657994
110GnRH signaling pathway_Homo sapiens_hsa049120.14506547
111Prion diseases_Homo sapiens_hsa050200.14350710
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.14335247
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13224826
114Inositol phosphate metabolism_Homo sapiens_hsa005620.11963706
115Galactose metabolism_Homo sapiens_hsa000520.11959237
116Rap1 signaling pathway_Homo sapiens_hsa040150.09985144

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