PTGER3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)8.83574477
2valine metabolic process (GO:0006573)8.67195342
3protein retention in ER lumen (GO:0006621)7.75866531
4intestinal cholesterol absorption (GO:0030299)7.47074459
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.43276435
6digestion (GO:0007586)6.93919044
7branched-chain amino acid metabolic process (GO:0009081)6.71527535
8branched-chain amino acid catabolic process (GO:0009083)6.61074409
9biotin metabolic process (GO:0006768)6.20109961
10metanephric nephron epithelium development (GO:0072243)6.12693998
11transcytosis (GO:0045056)5.86928272
12metanephric epithelium development (GO:0072207)5.75913377
13ovulation from ovarian follicle (GO:0001542)5.71532066
14cysteine metabolic process (GO:0006534)5.22107587
15cobalamin metabolic process (GO:0009235)4.76262432
16activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.74363366
17tricarboxylic acid metabolic process (GO:0072350)4.55993394
18NADH metabolic process (GO:0006734)4.44032872
19fatty acid beta-oxidation (GO:0006635)4.39770428
20positive regulation of glomerulus development (GO:0090193)4.35830169
21lysine metabolic process (GO:0006553)4.29408941
22lysine catabolic process (GO:0006554)4.29408941
23pentose-phosphate shunt (GO:0006098)4.23332734
24negative regulation of metanephros development (GO:0072217)4.22915763
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.18392426
26oxaloacetate metabolic process (GO:0006107)4.15950898
27response to water (GO:0009415)4.12887389
28COPI coating of Golgi vesicle (GO:0048205)4.12769584
29Golgi transport vesicle coating (GO:0048200)4.12769584
30nephron tubule development (GO:0072080)4.07841176
31fatty acid catabolic process (GO:0009062)4.05543232
322-oxoglutarate metabolic process (GO:0006103)4.03946747
33negative regulation of digestive system process (GO:0060457)3.99965119
34response to dietary excess (GO:0002021)3.93443924
35white fat cell differentiation (GO:0050872)3.89094476
36peptidyl-proline hydroxylation (GO:0019511)3.88885407
37NADPH regeneration (GO:0006740)3.87447495
38regulation of cAMP-dependent protein kinase activity (GO:2000479)3.86867509
39toxin transport (GO:1901998)3.86052008
40succinate metabolic process (GO:0006105)3.84974176
41polyol transport (GO:0015791)3.84838716
42fatty acid oxidation (GO:0019395)3.82886842
43brown fat cell differentiation (GO:0050873)3.81989631
44collecting duct development (GO:0072044)3.81250226
45actin filament depolymerization (GO:0030042)3.78016143
46aminoglycoside antibiotic metabolic process (GO:0030647)3.77087734
47lipid oxidation (GO:0034440)3.73726729
48mitochondrial calcium ion transport (GO:0006851)3.72341086
49carnitine shuttle (GO:0006853)3.71576984
50sterol catabolic process (GO:0016127)3.68724350
51cholesterol catabolic process (GO:0006707)3.68724350
52renal tubule development (GO:0061326)3.67500024
53quaternary ammonium group transport (GO:0015697)3.67198649
54cellular modified amino acid catabolic process (GO:0042219)3.66421206
55leukotriene biosynthetic process (GO:0019370)3.61533579
56aspartate family amino acid catabolic process (GO:0009068)3.58972727
57nephron epithelium development (GO:0072009)3.58741455
58short-chain fatty acid metabolic process (GO:0046459)3.57137988
59response to parathyroid hormone (GO:0071107)3.54221477
60amino-acid betaine transport (GO:0015838)3.53761314
61carnitine transport (GO:0015879)3.53761314
62low-density lipoprotein particle clearance (GO:0034383)3.53169082
63fatty acid transmembrane transport (GO:1902001)3.51971329
64triglyceride catabolic process (GO:0019433)3.48889531
65positive regulation of metanephros development (GO:0072216)3.46745731
66activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.43693897
67sulfur amino acid catabolic process (GO:0000098)3.40435000
68endocrine hormone secretion (GO:0060986)3.40225423
69cell volume homeostasis (GO:0006884)3.36358782
70response to mercury ion (GO:0046689)3.33593258
71regulation of sequestering of triglyceride (GO:0010889)3.33547836
72positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.31976855
73establishment of skin barrier (GO:0061436)3.31231681
74carnitine transmembrane transport (GO:1902603)3.31043484
75positive regulation of nuclease activity (GO:0032075)3.30819859
76tricarboxylic acid cycle (GO:0006099)3.28895895
77glycolipid catabolic process (GO:0019377)3.28142565
78fucose catabolic process (GO:0019317)3.26858596
79L-fucose metabolic process (GO:0042354)3.26858596
80L-fucose catabolic process (GO:0042355)3.26858596
81monocarboxylic acid catabolic process (GO:0072329)3.25437235
82galactose catabolic process (GO:0019388)3.19635104
83prostate gland growth (GO:0060736)3.14920784
84creatine metabolic process (GO:0006600)3.14194575
85proline biosynthetic process (GO:0006561)3.13973661
86regulation of water loss via skin (GO:0033561)3.12836040
87neutral lipid catabolic process (GO:0046461)3.12831357
88acylglycerol catabolic process (GO:0046464)3.12831357
89endoplasmic reticulum unfolded protein response (GO:0030968)3.07991332
90negative regulation of gluconeogenesis (GO:0045721)3.07515193
91acetyl-CoA metabolic process (GO:0006084)3.07177609
92protein hydroxylation (GO:0018126)3.06941123
93ovulation (GO:0030728)3.03619988
94membrane lipid catabolic process (GO:0046466)3.03500623
95L-serine transport (GO:0015825)3.01511743
96regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.01087376
97intestinal absorption (GO:0050892)3.00707465
98iron ion import (GO:0097286)3.00560490
99homocysteine metabolic process (GO:0050667)3.00124732
100lipid particle organization (GO:0034389)2.99984720
101hexose catabolic process (GO:0019320)2.99484054
102renal absorption (GO:0070293)2.99109103
103protein heterotrimerization (GO:0070208)2.97516137
104glycerolipid catabolic process (GO:0046503)2.97433562
105lipid storage (GO:0019915)2.97195245
106phosphate ion homeostasis (GO:0055062)2.96735577
107trivalent inorganic anion homeostasis (GO:0072506)2.96735577
108coenzyme A biosynthetic process (GO:0015937)2.96045298
109regulation of nuclease activity (GO:0032069)2.95457062
110cellular response to unfolded protein (GO:0034620)2.95166717
111response to endoplasmic reticulum stress (GO:0034976)2.92305622
112cranial nerve morphogenesis (GO:0021602)2.91745988
113regulation of glycogen (starch) synthase activity (GO:2000465)2.90876875
114organic cation transport (GO:0015695)2.89949422
115water transport (GO:0006833)2.87138405
116regulation of fatty acid oxidation (GO:0046320)2.86441769
117antigen processing and presentation via MHC class Ib (GO:0002475)2.85646153
118peptide catabolic process (GO:0043171)2.84423422
119mammary gland alveolus development (GO:0060749)2.83710887
120triglyceride metabolic process (GO:0006641)2.83120288
121cGMP-mediated signaling (GO:0019934)2.83061438
122growth hormone receptor signaling pathway (GO:0060396)2.82868105
123thioester biosynthetic process (GO:0035384)2.81212738
124acyl-CoA biosynthetic process (GO:0071616)2.81212738
125fatty acid homeostasis (GO:0055089)2.80817165
126coenzyme A metabolic process (GO:0015936)2.80323801
127negative regulation of macrophage differentiation (GO:0045650)2.80115362
128ER-nucleus signaling pathway (GO:0006984)2.79980957
129positive regulation of fatty acid oxidation (GO:0046321)2.79907125
130monosaccharide catabolic process (GO:0046365)2.79836347
131ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.79822771
132cellular response to topologically incorrect protein (GO:0035967)2.78906956
133excretion (GO:0007588)2.78825017
134metanephric tubule development (GO:0072170)2.78616869
135metanephric nephron tubule development (GO:0072234)2.78616869
136definitive hemopoiesis (GO:0060216)2.78567197
137response to growth hormone (GO:0060416)2.78187920
138GDP-mannose metabolic process (GO:0019673)2.77305391
139keratinization (GO:0031424)2.77272733
140response to phenylpropanoid (GO:0080184)2.76838457
141proline metabolic process (GO:0006560)2.76615753
142fucose metabolic process (GO:0006004)2.76380746
143regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.75726247
144negative regulation of amino acid transport (GO:0051956)2.75182754
145clathrin coat assembly (GO:0048268)2.73418125
146regulation of cholesterol efflux (GO:0010874)2.68430298
147negative regulation of appetite (GO:0032099)2.67909960
148negative regulation of response to food (GO:0032096)2.67909960
149regulation of glomerulus development (GO:0090192)2.67345294
150negative regulation of execution phase of apoptosis (GO:1900118)2.66162830
151response to copper ion (GO:0046688)2.64961965
152multicellular organismal water homeostasis (GO:0050891)2.64477516
153negative regulation of kidney development (GO:0090185)2.62092751
154response to lead ion (GO:0010288)2.59507904
155activation of protein kinase A activity (GO:0034199)2.56932353
156cardiovascular system development (GO:0072358)2.55300076
157fluid transport (GO:0042044)2.54815465
158response to thyroid hormone (GO:0097066)2.54812255
159retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54516219
160regulation of gonadotropin secretion (GO:0032276)2.53071333
161cellular response to growth hormone stimulus (GO:0071378)2.52389681
162positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.51201899
163dendritic spine morphogenesis (GO:0060997)2.50431436
164membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.50320665
165water homeostasis (GO:0030104)2.50017840
166amino-acid betaine metabolic process (GO:0006577)2.49149628
167retinol metabolic process (GO:0042572)2.49135044
168negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.48765552
169metanephric mesenchyme development (GO:0072075)2.47636171
170diacylglycerol metabolic process (GO:0046339)2.47236029
171camera-type eye morphogenesis (GO:0048593)2.47143152
172regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.45862726
173regulation of protein localization to cell surface (GO:2000008)2.45466997
174phosphate ion transport (GO:0006817)2.44943706
175glomerular filtration (GO:0003094)2.44337693
176inositol metabolic process (GO:0006020)2.43915226
177urate metabolic process (GO:0046415)2.42976396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.14664562
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.87420554
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.46364846
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.36662920
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.32760902
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.20156396
7GATA1_22025678_ChIP-Seq_K562_Human2.75779671
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.64129733
9* CLOCK_20551151_ChIP-Seq_293T_Human2.48956574
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.40085728
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.37100714
12SCL_19346495_ChIP-Seq_HPC-7_Human2.33541653
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23007176
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.18911983
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.18673813
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.18128765
17* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17750102
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.17723873
19GBX2_23144817_ChIP-Seq_PC3_Human2.08396454
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03985289
21* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00629496
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99309403
23* EED_16625203_ChIP-ChIP_MESCs_Mouse1.98507332
24* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96720910
25* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96720910
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.94887416
27EZH2_22144423_ChIP-Seq_EOC_Human1.94367276
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92904537
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.91869258
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.90184477
31* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83852656
32* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80121196
33* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79494919
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75972806
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74378823
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72345540
37ZNF263_19887448_ChIP-Seq_K562_Human1.70692896
38* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70475899
39* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69270156
40* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69226201
41GATA4_25053715_ChIP-Seq_YYC3_Human1.67706635
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67314593
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.66838893
44AHR_22903824_ChIP-Seq_MCF-7_Human1.66119758
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59358119
46* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59106922
47* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57853387
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.55698672
49* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55430237
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.53787822
51* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51398751
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50733457
53* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50564319
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.49487152
55* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47684931
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47676673
57* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45950872
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.45032335
59* ESR2_21235772_ChIP-Seq_MCF-7_Human1.44684385
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43826593
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42264598
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40507276
63* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35745082
64* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35565440
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.34326668
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33930027
67MYC_22102868_ChIP-Seq_BL_Human1.32003219
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31961523
69RNF2_27304074_Chip-Seq_NSC_Mouse1.29812647
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29368571
71VDR_21846776_ChIP-Seq_THP-1_Human1.27153008
72VDR_24763502_ChIP-Seq_THP-1_Human1.26818389
73LXR_22292898_ChIP-Seq_THP-1_Human1.26588969
74RUNX_20019798_ChIP-Seq_JUKART_Human1.25062546
75GATA6_25053715_ChIP-Seq_YYC3_Human1.24391295
76SOX2_20726797_ChIP-Seq_SW620_Human1.24186524
77* TP53_20018659_ChIP-ChIP_R1E_Mouse1.24157461
78PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24016985
79* SMAD4_21799915_ChIP-Seq_A2780_Human1.21841395
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20146505
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18967771
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18065741
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17926417
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17134256
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16984314
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.16714322
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15878205
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15828917
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15800140
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15707646
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14779162
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.14429881
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13960154
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13443989
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13400869
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13106690
97ERG_20517297_ChIP-Seq_VCAP_Human1.12687458
98ATF3_27146783_Chip-Seq_COLON_Human1.12200909
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11562369
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.11538053
101FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10778464
102GATA1_19941826_ChIP-Seq_K562_Human1.10760183
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10554147
104DROSHA_22980978_ChIP-Seq_HELA_Human1.10542718
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09020419
106CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09000843
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08970347
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08609406
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07692341
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.07043702
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.06957112
112CDX2_20551321_ChIP-Seq_CACO-2_Human1.06321058
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06161796
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05988785
115PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05654650
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.05614414
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04646591
118RXR_22108803_ChIP-Seq_LS180_Human1.04575844
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04452354
120GATA2_21666600_ChIP-Seq_HMVEC_Human1.03880478
121GATA2_19941826_ChIP-Seq_K562_Human1.03567264
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03382946
123RACK7_27058665_Chip-Seq_MCF-7_Human1.02328327
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01984257
125P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00108241
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00064717
127CBP_21632823_ChIP-Seq_H3396_Human0.99523084
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98487125
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98147040
130NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98147040
131* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97805169
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97510516
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97101412
134NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96685369
135ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96104244
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95024642
137* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94891541
138IGF1R_20145208_ChIP-Seq_DFB_Human0.94772623
139MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94170288
140* REST_21632747_ChIP-Seq_MESCs_Mouse0.94111139
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93901594
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93712369
143SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92926199
144EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92673812
145P68_20966046_ChIP-Seq_HELA_Human0.92177429
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91675576
147FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91575879
148* ERG_21242973_ChIP-ChIP_JURKAT_Human0.91566061
149IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91490666
150BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91324661
151GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91259616
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91083473
153GATA3_24758297_ChIP-Seq_MCF-7_Human0.89132756
154CJUN_26792858_Chip-Seq_BT549_Human0.88686917
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.88199038
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.88199038
157SOX2_21211035_ChIP-Seq_LN229_Gbm0.88171643
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.87916789
159ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87876587
160PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87583906
161AR_25329375_ChIP-Seq_VCAP_Human0.87184602
162RUNX1_27514584_Chip-Seq_MCF-7_Human0.86961961
163NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86340892
164ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85131845
165P300_27268052_Chip-Seq_Bcells_Human0.84571639
166* TBL1_22424771_ChIP-Seq_293T_Human0.84166465
167* SA1_27219007_Chip-Seq_ERYTHROID_Human0.84090052
168EP300_21415370_ChIP-Seq_HL-1_Mouse0.83944662
169* MYB_26560356_Chip-Seq_TH2_Human0.83917437
170TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83445262
171AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83411738
172ESET_19884257_ChIP-Seq_ESCs_Mouse0.82816777
173PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82789580
174KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81486798
175CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81378814
176IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80619456
177NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80213606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption5.33714678
2MP0005670_abnormal_white_adipose4.63108535
3MP0005220_abnormal_exocrine_pancreas4.60089565
4MP0005083_abnormal_biliary_tract4.53638734
5MP0005365_abnormal_bile_salt4.28781942
6MP0005666_abnormal_adipose_tissue3.11478881
7MP0004043_abnormal_pH_regulation3.07958074
8MP0003959_abnormal_lean_body2.79183952
9MP0005084_abnormal_gallbladder_morpholo2.78978395
10MP0002876_abnormal_thyroid_physiology2.78664117
11MP0009780_abnormal_chondrocyte_physiolo2.68994851
12MP0003868_abnormal_feces_composition2.67424059
13MP0004130_abnormal_muscle_cell2.66459222
14MP0001756_abnormal_urination2.65446311
15MP0005503_abnormal_tendon_morphology2.55713619
16MP0002796_impaired_skin_barrier2.51789671
17MP0005379_endocrine/exocrine_gland_phen2.40983788
18MP0005332_abnormal_amino_acid2.35611013
19MP0004185_abnormal_adipocyte_glucose2.34873343
20MP0005375_adipose_tissue_phenotype2.31480944
21* MP0009643_abnormal_urine_homeostasis2.30192942
22MP0003186_abnormal_redox_activity2.03119691
23MP0004147_increased_porphyrin_level1.97592983
24MP0002638_abnormal_pupillary_reflex1.95912281
25MP0002118_abnormal_lipid_homeostasis1.86226382
26MP0008438_abnormal_cutaneous_collagen1.81717481
27MP0001664_abnormal_digestion1.81436908
28MP0010329_abnormal_lipoprotein_level1.74558944
29MP0004019_abnormal_vitamin_homeostasis1.71677311
30MP0006276_abnormal_autonomic_nervous1.65002024
31MP0002971_abnormal_brown_adipose1.64803134
32MP0006036_abnormal_mitochondrial_physio1.64792693
33MP0005334_abnormal_fat_pad1.64615264
34* MP0005535_abnormal_body_temperature1.64223993
35MP0001873_stomach_inflammation1.64181619
36MP0002693_abnormal_pancreas_physiology1.62883326
37MP0002166_altered_tumor_susceptibility1.62546919
38MP0000003_abnormal_adipose_tissue1.62130909
39MP0001765_abnormal_ion_homeostasis1.58405757
40MP0005448_abnormal_energy_balance1.58287180
41MP0008961_abnormal_basal_metabolism1.51989562
42MP0003300_gastrointestinal_ulcer1.49774592
43MP0001944_abnormal_pancreas_morphology1.45344388
44MP0010234_abnormal_vibrissa_follicle1.45296947
45MP0002970_abnormal_white_adipose1.45265627
46MP0003191_abnormal_cellular_cholesterol1.43753544
47MP0002108_abnormal_muscle_morphology1.42044870
48MP0002136_abnormal_kidney_physiology1.41601194
49MP0009384_cardiac_valve_regurgitation1.38287238
50MP0005636_abnormal_mineral_homeostasis1.37776177
51MP0002078_abnormal_glucose_homeostasis1.35757339
52MP0003011_delayed_dark_adaptation1.34368438
53MP0006138_congestive_heart_failure1.31189953
54MP0002139_abnormal_hepatobiliary_system1.30592491
55MP0003879_abnormal_hair_cell1.27288335
56MP0005248_abnormal_Harderian_gland1.23189358
57MP0005085_abnormal_gallbladder_physiolo1.21955443
58MP0001881_abnormal_mammary_gland1.21733634
59MP0002396_abnormal_hematopoietic_system1.19682178
60MP0003195_calcinosis1.19544710
61MP0004264_abnormal_extraembryonic_tissu1.18409069
62MP0009115_abnormal_fat_cell1.17148971
63MP0000013_abnormal_adipose_tissue1.16314890
64MP0000427_abnormal_hair_cycle1.15353671
65MP0005584_abnormal_enzyme/coenzyme_acti1.15021051
66MP0005501_abnormal_skin_physiology1.13797590
67MP0001661_extended_life_span1.13411133
68MP0005452_abnormal_adipose_tissue1.12240138
69MP0001727_abnormal_embryo_implantation1.10153918
70MP0010386_abnormal_urinary_bladder1.09659667
71MP0002928_abnormal_bile_duct1.08489727
72MP0001958_emphysema1.08063887
73MP0005058_abnormal_lysosome_morphology1.07970359
74MP0005319_abnormal_enzyme/_coenzyme1.07624868
75MP0000490_abnormal_crypts_of1.07409139
76MP0004215_abnormal_myocardial_fiber1.06754424
77MP0001764_abnormal_homeostasis1.06648141
78MP0003705_abnormal_hypodermis_morpholog1.05952767
79MP0000534_abnormal_ureter_morphology1.05287109
80MP0003950_abnormal_plasma_membrane1.03793361
81MP0002006_tumorigenesis1.03708922
82MP0000613_abnormal_salivary_gland0.99369874
83MP0002896_abnormal_bone_mineralization0.98745177
84MP0000609_abnormal_liver_physiology0.97858467
85* MP0003638_abnormal_response/metabolism_0.96802818
86MP0003690_abnormal_glial_cell0.96027521
87MP0002168_other_aberrant_phenotype0.94482004
88MP0003279_aneurysm0.93380546
89MP0002295_abnormal_pulmonary_circulatio0.92914722
90MP0001346_abnormal_lacrimal_gland0.92624762
91MP0001879_abnormal_lymphatic_vessel0.92123962
92MP0006054_spinal_hemorrhage0.89032091
93MP0004084_abnormal_cardiac_muscle0.88422608
94* MP0003953_abnormal_hormone_level0.87146514
95MP0005360_urolithiasis0.87073163
96MP0003724_increased_susceptibility_to0.85937697
97MP0004272_abnormal_basement_membrane0.85858027
98MP0000343_altered_response_to0.85063654
99MP0000371_diluted_coat_color0.84646469
100MP0000465_gastrointestinal_hemorrhage0.83711870
101MP0003656_abnormal_erythrocyte_physiolo0.83589792
102MP0003183_abnormal_peptide_metabolism0.83136343
103MP0004233_abnormal_muscle_weight0.83129703
104MP0009765_abnormal_xenobiotic_induced0.82702096
105MP0001663_abnormal_digestive_system0.82620981
106MP0002135_abnormal_kidney_morphology0.81230921
107MP0005464_abnormal_platelet_physiology0.79214364
108MP0000230_abnormal_systemic_arterial0.78944549
109MP0002837_dystrophic_cardiac_calcinosis0.77701819
110MP0001845_abnormal_inflammatory_respons0.76051380
111MP0001544_abnormal_cardiovascular_syste0.75983120
112MP0005385_cardiovascular_system_phenoty0.75983120
113MP0005647_abnormal_sex_gland0.74441013
114MP0003045_fibrosis0.74027648
115MP0002254_reproductive_system_inflammat0.73577943
116MP0002069_abnormal_eating/drinking_beha0.71092206
117MP0000598_abnormal_liver_morphology0.68196321
118MP0005275_abnormal_skin_tensile0.68149701
119MP0000538_abnormal_urinary_bladder0.67850237
120MP0003828_pulmonary_edema0.64771346
121MP0003948_abnormal_gas_homeostasis0.64641422
122MP0002009_preneoplasia0.64592602
123MP0001348_abnormal_lacrimal_gland0.64378147
124MP0001919_abnormal_reproductive_system0.63007708
125MP0008469_abnormal_protein_level0.62955549
126MP0005165_increased_susceptibility_to0.61996232
127MP0005310_abnormal_salivary_gland0.61181228
128MP0002909_abnormal_adrenal_gland0.61115186
129* MP0009642_abnormal_blood_homeostasis0.60909339
130MP0005620_abnormal_muscle_contractility0.60844831
131MP0010678_abnormal_skin_adnexa0.60494632
132MP0004858_abnormal_nervous_system0.59576807
133MP0003763_abnormal_thymus_physiology0.59248741
134MP0000685_abnormal_immune_system0.58662131
135MP0001270_distended_abdomen0.57881134
136MP0004808_abnormal_hematopoietic_stem0.56946310
137MP0002089_abnormal_postnatal_growth/wei0.56025240
138MP0000681_abnormal_thyroid_gland0.55421551
139MP0003795_abnormal_bone_structure0.54829107
140MP0004036_abnormal_muscle_relaxation0.54463992
141MP0009703_decreased_birth_body0.54339490
142MP0003942_abnormal_urinary_system0.53313254
143MP0000778_abnormal_nervous_system0.52700375
144MP0000627_abnormal_mammary_gland0.51585772
145MP0005595_abnormal_vascular_smooth0.50612865
146MP0004085_abnormal_heartbeat0.50076629

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.03713305
2Hypokalemic alkalosis (HP:0001949)5.87764556
3Abnormality of chloride homeostasis (HP:0011422)5.18555522
4Hypomagnesemia (HP:0002917)4.90097540
5Hyperactive renin-angiotensin system (HP:0000841)4.89984436
6Renal salt wasting (HP:0000127)4.85820954
7Hyperglycinuria (HP:0003108)4.83574072
8Increased circulating renin level (HP:0000848)4.61354301
9Gout (HP:0001997)4.59076838
10Polyuria (HP:0000103)4.40651943
11Abnormality of magnesium homeostasis (HP:0004921)4.40489218
12Abnormality of renal excretion (HP:0011036)4.30306612
13Abnormality of fatty-acid metabolism (HP:0004359)4.21383725
14Hyperaldosteronism (HP:0000859)4.19875130
15Abnormal urine output (HP:0012590)4.19322614
16Abnormality of glycine metabolism (HP:0010895)3.77680263
17Abnormality of serine family amino acid metabolism (HP:0010894)3.77680263
18Ketoacidosis (HP:0001993)3.57906829
19Ketosis (HP:0001946)3.45365242
20Hyperuricemia (HP:0002149)3.29210251
21Increased purine levels (HP:0004368)3.29210251
22Polydipsia (HP:0001959)3.22507583
23Abnormal drinking behavior (HP:0030082)3.22507583
24Generalized aminoaciduria (HP:0002909)3.13794692
25Alkalosis (HP:0001948)3.05734875
26Abnormality of proline metabolism (HP:0010907)3.01472762
27Hydroxyprolinuria (HP:0003080)3.01472762
28Tetany (HP:0001281)2.99395591
29Oligomenorrhea (HP:0000876)2.96856796
30Abnormality of subcutaneous fat tissue (HP:0001001)2.94354384
31Tubular atrophy (HP:0000092)2.91015813
32Hypokalemia (HP:0002900)2.88114648
33Pancreatitis (HP:0001733)2.86241747
34Abnormality of renin-angiotensin system (HP:0000847)2.85660248
35Decreased subcutaneous fat (HP:0001002)2.78594734
36Abnormality of dicarboxylic acid metabolism (HP:0010995)2.74945624
37Dicarboxylic aciduria (HP:0003215)2.74945624
38Potter facies (HP:0002009)2.68321379
39Facial shape deformation (HP:0011334)2.68321379
40Adrenal overactivity (HP:0002717)2.62060806
41Abnormality of purine metabolism (HP:0004352)2.60004403
42Steatorrhea (HP:0002570)2.58711894
43Short chin (HP:0000331)2.58108865
44Proximal tubulopathy (HP:0000114)2.56582808
45Chondrocalcinosis (HP:0000934)2.53806973
46Hypoglycemic coma (HP:0001325)2.51867916
47Aortic aneurysm (HP:0004942)2.50765302
48Vacuolated lymphocytes (HP:0001922)2.48387429
49Abnormal platelet function (HP:0011869)2.45107305
50Impaired platelet aggregation (HP:0003540)2.45107305
51Type I diabetes mellitus (HP:0100651)2.41170809
52Abnormality of Sharpey fibers (HP:0100685)2.41129268
53Hyperglycinemia (HP:0002154)2.39240828
54Long foot (HP:0001833)2.37885978
55Nephrocalcinosis (HP:0000121)2.37603299
56Hypertriglyceridemia (HP:0002155)2.37426618
57Abnormality of nail color (HP:0100643)2.36532462
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35137435
59Large hands (HP:0001176)2.34680029
60Abnormality of the intrinsic pathway (HP:0010989)2.31545503
61Acanthosis nigricans (HP:0000956)2.30612264
62Tubulointerstitial fibrosis (HP:0005576)2.29943715
63Large eyes (HP:0001090)2.29308455
64Beaking of vertebral bodies (HP:0004568)2.28640809
65Polyphagia (HP:0002591)2.28262729
66Abnormality of the lumbar spine (HP:0100712)2.24261207
67Increased muscle lipid content (HP:0009058)2.24131015
68Abnormality of sodium homeostasis (HP:0010931)2.22596846
69Hyperammonemia (HP:0001987)2.21276647
70Abnormality of potassium homeostasis (HP:0011042)2.21102708
71Abnormal eating behavior (HP:0100738)2.20053514
72Dysostosis multiplex (HP:0000943)2.18462183
73Hypercalciuria (HP:0002150)2.18252137
74Hepatic necrosis (HP:0002605)2.17917762
75Urinary glycosaminoglycan excretion (HP:0003541)2.16628725
76Mucopolysacchariduria (HP:0008155)2.16628725
77Growth hormone excess (HP:0000845)2.14691760
78Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12719625
79Bone cyst (HP:0012062)2.09996298
80Progressive muscle weakness (HP:0003323)2.09636780
81Methylmalonic aciduria (HP:0012120)2.09548468
82Concave nail (HP:0001598)2.09274409
83Petechiae (HP:0000967)2.08941399
84Hypoplasia of the pons (HP:0012110)2.06146688
85Rectal prolapse (HP:0002035)2.05756353
86Hypothermia (HP:0002045)2.05718684
87Thoracolumbar scoliosis (HP:0002944)2.04400187
88Myoglobinuria (HP:0002913)2.04318142
89Persistence of primary teeth (HP:0006335)2.04251321
90Generalized muscle weakness (HP:0003324)2.03213690
91Joint stiffness (HP:0001387)2.03022473
92Dehydration (HP:0001944)2.02976602
93Vomiting (HP:0002013)2.02260550
94Hyperphosphaturia (HP:0003109)2.01786606
95Hypotension (HP:0002615)2.00841684
96Thoracic kyphosis (HP:0002942)1.99502782
97Rickets (HP:0002748)1.97287318
98Metaphyseal dysplasia (HP:0100255)1.96273619
99Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95378857
100Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95378857
101Abnormality of polysaccharide metabolism (HP:0011012)1.95378857
102Fatigue (HP:0012378)1.95378036
103Exocrine pancreatic insufficiency (HP:0001738)1.94237231
104Hypoproteinemia (HP:0003075)1.91996652
105Fat malabsorption (HP:0002630)1.91463459
106Hyponatremia (HP:0002902)1.88910780
107Limb hypertonia (HP:0002509)1.87885535
108Lymphangioma (HP:0100764)1.85442580
109Abnormality of alanine metabolism (HP:0010916)1.85293065
110Hyperalaninemia (HP:0003348)1.85293065
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85293065
112Prenatal maternal abnormality (HP:0002686)1.85155153
113Metabolic acidosis (HP:0001942)1.82791290
114Osteopenia (HP:0000938)1.82275887
115Nausea (HP:0002018)1.80258567
116Prolonged bleeding time (HP:0003010)1.80187777
117Menorrhagia (HP:0000132)1.79598051
118Abnormal protein N-linked glycosylation (HP:0012347)1.79577250
119Abnormal glycosylation (HP:0012345)1.79577250
120Nephrogenic diabetes insipidus (HP:0009806)1.79175774
121Neonatal onset (HP:0003623)1.78750290
122Cortical dysplasia (HP:0002539)1.77830742
123Abnormal urine phosphate concentration (HP:0012599)1.75060744
124Abnormality of urine glucose concentration (HP:0011016)1.72508121
125Glycosuria (HP:0003076)1.72508121
126Abnormality of molar morphology (HP:0011070)1.71761597
127Abnormality of molar (HP:0011077)1.71761597
128Skin nodule (HP:0200036)1.70351646
129Termporal pattern (HP:0011008)1.66531369
130Insidious onset (HP:0003587)1.66531369
131Abnormality of permanent molar morphology (HP:0011071)1.64918076
132Abnormality of the dental root (HP:0006486)1.64918076
133Taurodontia (HP:0000679)1.64918076
134Tubulointerstitial abnormality (HP:0001969)1.63968481
135Sparse lateral eyebrow (HP:0005338)1.63843521
136Decreased circulating renin level (HP:0003351)1.63471884
137Focal segmental glomerulosclerosis (HP:0000097)1.61319581
138Hypophosphatemia (HP:0002148)1.60728222
139Prominent supraorbital ridges (HP:0000336)1.59462664
140Pigmentary retinal degeneration (HP:0001146)1.57283424
141Broad metatarsal (HP:0001783)1.53971487
142Thin bony cortex (HP:0002753)1.53781447
143Visceral angiomatosis (HP:0100761)1.53215889
144Hypercortisolism (HP:0001578)1.53076449
145Abnormality of the dental pulp (HP:0006479)1.51430430
146Abnormality of renal resorption (HP:0011038)1.49526800
147Abnormality of calcium-phosphate metabolism (HP:0100530)1.48574602
148Glomerulosclerosis (HP:0000096)1.45052241
149Infantile muscular hypotonia (HP:0008947)1.44251029
150Accelerated skeletal maturation (HP:0005616)1.43224345
151Right ventricular cardiomyopathy (HP:0011663)1.40214346
152Neoplasm of the heart (HP:0100544)1.37599339
153Polycythemia (HP:0001901)1.37365920
154Congenital ichthyosiform erythroderma (HP:0007431)1.36531660
155Advanced eruption of teeth (HP:0006288)1.35921717
156Hemangiomatosis (HP:0007461)1.35904586
157Unilateral renal agenesis (HP:0000122)1.35721520
158Intellectual disability, moderate (HP:0002342)1.35213578
159Hypotrichosis (HP:0001006)1.34859813
160Conjunctival hamartoma (HP:0100780)1.34365425
161Hyperkalemia (HP:0002153)1.33010714
162Insulin-resistant diabetes mellitus (HP:0000831)1.32834112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.52474306
2WNK34.47986028
3TRIB34.03547175
4ERN13.70532830
5EPHA33.31925164
6CAMK1D2.87963440
7MAPKAPK32.72609849
8OXSR12.54426820
9PKN22.49337413
10SCYL22.44526909
11EEF2K2.41802303
12WNK42.41470384
13EPHB12.40434974
14LMTK22.03890133
15FLT31.87113104
16EIF2AK31.86930857
17PDK41.83870037
18PDK31.83870037
19MAP2K21.78833525
20FRK1.76976184
21CAMK1G1.76518262
22FER1.74999896
23SIK11.73801199
24MARK11.57199720
25TESK11.44165360
26MAP2K31.42921711
27ZAP701.40959931
28PDK21.35280259
29DMPK1.34326536
30CAMKK21.34143422
31LRRK21.32507913
32NME21.28576936
33KIT1.28468335
34BMPR21.19456840
35RPS6KB21.13499571
36MAP2K11.11697605
37TAOK31.09788259
38MAP2K71.06002457
39ERBB31.02614537
40DDR21.01369716
41IRAK30.99919807
42LATS20.98862777
43TGFBR20.96635351
44NTRK30.95709455
45RET0.93527933
46ICK0.91616487
47MAP4K10.91299162
48TIE10.89549823
49TRPM70.89488720
50MAPKAPK50.88207876
51MATK0.87651459
52INSRR0.87186876
53PAK20.86032830
54MST1R0.84604692
55STK30.79254649
56PIM20.79212698
57MAP3K40.77945310
58CASK0.77436956
59PRKAA20.71604838
60JAK30.70929388
61TBK10.69765960
62PDK10.69479769
63PIK3CA0.69319451
64MAP3K30.68684631
65MAP3K60.68262891
66MARK20.68046121
67PDPK10.65294851
68DYRK20.64841944
69MAP2K40.63595907
70MAP2K60.63212846
71TEC0.62351514
72FGFR30.59572642
73BCR0.59429828
74NTRK10.59066570
75DYRK30.58440177
76NME10.58262073
77PINK10.57773907
78MINK10.56618512
79JAK20.56395268
80BTK0.56155256
81CAMKK10.55748934
82PTK60.55517682
83WNK10.54577355
84CDK190.53446459
85BRSK20.53065211
86KSR20.52861415
87MAPK130.52595840
88PRKG20.52433999
89ADRBK10.52344526
90TGFBR10.52317476
91PRKAA10.51932379
92MTOR0.50511201
93CSF1R0.50442316
94GSK3A0.49578099
95EPHB20.48170282
96ILK0.47893892
97MAPK40.47396692
98SGK10.47396627
99HIPK20.47191658
100GRK50.45564136
101LATS10.41737010
102IRAK40.41484741
103RPS6KB10.41371147
104PDGFRB0.41290738
105SGK2230.41063287
106SGK4940.41063287
107MAP3K20.40743597
108MYLK0.40380868
109DAPK20.39486117
110RPS6KA20.38235851
111PRKG10.37998532
112PIK3CG0.37497051
113CDK90.37151422
114PRKD10.36915448
115PDGFRA0.36730060
116DYRK1B0.36638989
117CDK60.36468435
118PKN10.36004097
119ABL20.35795381
120STK390.34078570
121MAPK110.33656309
122PAK30.33511097
123KSR10.33475941
124MAP3K70.32919457
125MAPK120.32871487
126NLK0.32795648
127SGK20.32648072
128RIPK10.31079131
129CAMK10.31053185
130RPS6KA30.30330041
131DAPK10.29954028
132CLK10.29765312
133MAP3K10.29220367
134STK38L0.28537952
135FGFR20.27220377
136JAK10.27009836
137PRKACA0.26985916
138MAPK150.26963230
139GRK10.26054893
140TAOK10.25639909
141IGF1R0.25556066
142PRKCG0.25500648
143CDK50.25447399
144EIF2AK10.25129775
145RAF10.24866999
146IRAK20.24508116
147MAPK70.24338274
148MAPK30.23887511
149PRKACB0.23780841
150PRKACG0.23286055
151TYK20.22224994
152SGK30.21594340
153ACVR1B0.21148242
154PRKCH0.20828971
155IRAK10.19158434

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049724.73812182
2Propanoate metabolism_Homo sapiens_hsa006404.34915243
3Protein digestion and absorption_Homo sapiens_hsa049743.95331512
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.77858831
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.58262671
6Fat digestion and absorption_Homo sapiens_hsa049753.53710251
7Glycerolipid metabolism_Homo sapiens_hsa005613.38999686
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84343115
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.53148820
10Renin-angiotensin system_Homo sapiens_hsa046142.30252541
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.28062083
12Phenylalanine metabolism_Homo sapiens_hsa003602.20376487
13Fatty acid degradation_Homo sapiens_hsa000712.15417749
14Pyruvate metabolism_Homo sapiens_hsa006202.14314373
15Folate biosynthesis_Homo sapiens_hsa007902.08817727
16Fatty acid metabolism_Homo sapiens_hsa012122.06670432
17Protein export_Homo sapiens_hsa030601.89686355
18* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.82244722
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69769344
20PPAR signaling pathway_Homo sapiens_hsa033201.69748629
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65350211
22Fatty acid biosynthesis_Homo sapiens_hsa000611.64683989
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.64049174
24Carbon metabolism_Homo sapiens_hsa012001.51395095
25Histidine metabolism_Homo sapiens_hsa003401.50141345
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.49085212
27Renin secretion_Homo sapiens_hsa049241.45597040
28beta-Alanine metabolism_Homo sapiens_hsa004101.41962071
29Collecting duct acid secretion_Homo sapiens_hsa049661.38962302
30Gap junction_Homo sapiens_hsa045401.34356957
31N-Glycan biosynthesis_Homo sapiens_hsa005101.33508801
32Other glycan degradation_Homo sapiens_hsa005111.28178215
33Gastric acid secretion_Homo sapiens_hsa049711.21607424
34Ovarian steroidogenesis_Homo sapiens_hsa049131.21134140
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20817769
36Butanoate metabolism_Homo sapiens_hsa006501.18494161
37Peroxisome_Homo sapiens_hsa041461.09121133
38Adipocytokine signaling pathway_Homo sapiens_hsa049201.08914145
39AMPK signaling pathway_Homo sapiens_hsa041521.08896516
40Vitamin digestion and absorption_Homo sapiens_hsa049771.06545878
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05746326
42GABAergic synapse_Homo sapiens_hsa047271.03962842
43Circadian entrainment_Homo sapiens_hsa047131.03640744
44Sulfur metabolism_Homo sapiens_hsa009201.03581534
45Tyrosine metabolism_Homo sapiens_hsa003501.00399451
46Biosynthesis of amino acids_Homo sapiens_hsa012301.00128454
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00012490
48Sphingolipid metabolism_Homo sapiens_hsa006000.97170758
49Long-term depression_Homo sapiens_hsa047300.96116725
50Sulfur relay system_Homo sapiens_hsa041220.94704294
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94511794
52Tryptophan metabolism_Homo sapiens_hsa003800.93651852
53Type II diabetes mellitus_Homo sapiens_hsa049300.91595797
54Circadian rhythm_Homo sapiens_hsa047100.88743400
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88739453
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87229524
57Morphine addiction_Homo sapiens_hsa050320.84692553
58Pentose phosphate pathway_Homo sapiens_hsa000300.83265948
59Focal adhesion_Homo sapiens_hsa045100.82754236
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82657782
61Fructose and mannose metabolism_Homo sapiens_hsa000510.82426318
62Glutamatergic synapse_Homo sapiens_hsa047240.77616932
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77369049
64Serotonergic synapse_Homo sapiens_hsa047260.77272160
65Dopaminergic synapse_Homo sapiens_hsa047280.76974538
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76774738
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76123571
68Prolactin signaling pathway_Homo sapiens_hsa049170.76096192
69Choline metabolism in cancer_Homo sapiens_hsa052310.73987825
70Insulin signaling pathway_Homo sapiens_hsa049100.73154234
71Axon guidance_Homo sapiens_hsa043600.71183409
72Melanoma_Homo sapiens_hsa052180.70438779
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70047736
74Insulin resistance_Homo sapiens_hsa049310.69052863
75Insulin secretion_Homo sapiens_hsa049110.68722414
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68244093
77Ras signaling pathway_Homo sapiens_hsa040140.68141794
78Renal cell carcinoma_Homo sapiens_hsa052110.68069033
79Cholinergic synapse_Homo sapiens_hsa047250.67719068
80Starch and sucrose metabolism_Homo sapiens_hsa005000.67644700
81Dilated cardiomyopathy_Homo sapiens_hsa054140.66306080
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65577100
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64859859
84Dorso-ventral axis formation_Homo sapiens_hsa043200.64121524
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63702444
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.63259929
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62980346
88Oxytocin signaling pathway_Homo sapiens_hsa049210.62670192
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62240712
90ABC transporters_Homo sapiens_hsa020100.61711761
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.61489599
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60249937
93Glutathione metabolism_Homo sapiens_hsa004800.59598679
94Estrogen signaling pathway_Homo sapiens_hsa049150.59415197
95Rap1 signaling pathway_Homo sapiens_hsa040150.59257367
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57848388
97Cocaine addiction_Homo sapiens_hsa050300.57040062
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.56814696
99Arginine and proline metabolism_Homo sapiens_hsa003300.56160648
100Salivary secretion_Homo sapiens_hsa049700.55733797
101Synaptic vesicle cycle_Homo sapiens_hsa047210.54980749
102Fatty acid elongation_Homo sapiens_hsa000620.54891426
103GnRH signaling pathway_Homo sapiens_hsa049120.54890208
104Lysosome_Homo sapiens_hsa041420.53307648
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53231787
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52956820
107* cAMP signaling pathway_Homo sapiens_hsa040240.52439841
108Amphetamine addiction_Homo sapiens_hsa050310.52406801
109Selenocompound metabolism_Homo sapiens_hsa004500.51813956
110Ribosome_Homo sapiens_hsa030100.51385704
111ErbB signaling pathway_Homo sapiens_hsa040120.51331857
112Platelet activation_Homo sapiens_hsa046110.50586363
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50209324
114FoxO signaling pathway_Homo sapiens_hsa040680.48592681
115Retinol metabolism_Homo sapiens_hsa008300.47487265
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47454874
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47074576
118Arachidonic acid metabolism_Homo sapiens_hsa005900.45952095
119Metabolic pathways_Homo sapiens_hsa011000.45821503
120Galactose metabolism_Homo sapiens_hsa000520.45673621
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45070380
122Inositol phosphate metabolism_Homo sapiens_hsa005620.44919805
123Arginine biosynthesis_Homo sapiens_hsa002200.44900369
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44252948
125Acute myeloid leukemia_Homo sapiens_hsa052210.40352814
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40246061
127Vibrio cholerae infection_Homo sapiens_hsa051100.39804433
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.37967317
129Influenza A_Homo sapiens_hsa051640.36061378
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.35042550
131mTOR signaling pathway_Homo sapiens_hsa041500.33370579
132Parkinsons disease_Homo sapiens_hsa050120.32624623
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31536189
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31494349
135Toxoplasmosis_Homo sapiens_hsa051450.31010468
136Endometrial cancer_Homo sapiens_hsa052130.28007709
137Small cell lung cancer_Homo sapiens_hsa052220.26559748
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26284871
139Thyroid hormone synthesis_Homo sapiens_hsa049180.26022555
140Glucagon signaling pathway_Homo sapiens_hsa049220.25155659
141ECM-receptor interaction_Homo sapiens_hsa045120.24464965
142Non-small cell lung cancer_Homo sapiens_hsa052230.24030177
143Regulation of autophagy_Homo sapiens_hsa041400.21699192
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.19381752
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18842308
146Bile secretion_Homo sapiens_hsa049760.17972402
147Hepatitis C_Homo sapiens_hsa051600.17889476
148VEGF signaling pathway_Homo sapiens_hsa043700.17299056
149Thyroid cancer_Homo sapiens_hsa052160.16670108
150Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15750540
151Linoleic acid metabolism_Homo sapiens_hsa005910.15633075
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.15210662
153Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.14746501
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12990742
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12609062
156HIF-1 signaling pathway_Homo sapiens_hsa040660.12079083

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