ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sleep (GO:0030431)	6.21802960
2	acrosome reaction (GO:0007340)	5.40808596
3	cellular response to nicotine (GO:0071316)	4.84974971
4	artery smooth muscle contraction (GO:0014824)	4.20129146
5	positive regulation of prostaglandin secretion (GO:0032308)	4.14844437
6	gonadal mesoderm development (GO:0007506)	4.13803695
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.09855289
8	histamine secretion (GO:0001821)	4.03244684
9	positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)	3.81282726
10	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.79571533
11	macroautophagy (GO:0016236)	3.76325981
12	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.75936204
13	positive regulation of fatty acid transport (GO:2000193)	3.60982734
14	piRNA metabolic process (GO:0034587)	3.59039373
15	mitochondrial DNA replication (GO:0006264)	3.58592249
16	regulation of prostaglandin secretion (GO:0032306)	3.55736375
17	positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)	3.54385760
18	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.50497569
19	L-serine transport (GO:0015825)	3.49038118
20	tonic smooth muscle contraction (GO:0014820)	3.48219594
21	cellular ketone body metabolic process (GO:0046950)	3.46924383
22	auditory receptor cell stereocilium organization (GO:0060088)	3.44191521
23	regulation of memory T cell differentiation (GO:0043380)	3.41970587
24	protein polyglutamylation (GO:0018095)	3.32114706
25	calcium ion-dependent exocytosis (GO:0017156)	3.31403332
26	vascular smooth muscle contraction (GO:0014829)	3.28806411
27	positive regulation by host of viral transcription (GO:0043923)	3.28770386
28	axoneme assembly (GO:0035082)	3.27498053
29	histamine transport (GO:0051608)	3.26623724
30	regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)	3.19435897
31	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.18879262
32	retinal rod cell development (GO:0046548)	3.16909954
33	ubiquinone metabolic process (GO:0006743)	3.13149261
34	ubiquinone biosynthetic process (GO:0006744)	3.12609237
35	positive regulation of calcium-mediated signaling (GO:0050850)	3.11556743
36	response to ischemia (GO:0002931)	3.10711631
37	positive regulation of icosanoid secretion (GO:0032305)	3.05691965
38	glycosphingolipid biosynthetic process (GO:0006688)	3.05551285
39	ketone body metabolic process (GO:1902224)	3.00867131
40	single strand break repair (GO:0000012)	2.98635449
41	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.96596518
42	magnesium ion transport (GO:0015693)	2.94552963
43	potassium ion import (GO:0010107)	2.92684976
44	negative T cell selection (GO:0043383)	2.89440926
45	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.87893248
46	regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)	2.86895475
47	positive regulation of T-helper 1 type immune response (GO:0002827)	2.84928683
48	negative regulation of macrophage differentiation (GO:0045650)	2.83893069
49	serine transport (GO:0032329)	2.83396073
50	sialylation (GO:0097503)	2.83333896
51	azole transport (GO:0045117)	2.81663828
52	adenosine metabolic process (GO:0046085)	2.79490288
53	regulation of alpha-beta T cell proliferation (GO:0046640)	2.79043636
54	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.78064257
55	modulation by host of viral transcription (GO:0043921)	2.73696998
56	modulation by host of symbiont transcription (GO:0052472)	2.73696998
57	primary amino compound metabolic process (GO:1901160)	2.73364237
58	peptidyl-cysteine modification (GO:0018198)	2.73212047
59	reflex (GO:0060004)	2.72181298
60	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.71577557
61	response to testosterone (GO:0033574)	2.70208859
62	regulation of germinal center formation (GO:0002634)	2.69690145
63	DNA methylation involved in gamete generation (GO:0043046)	2.69270016
64	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.68651572
65	regulation of mitotic spindle checkpoint (GO:1903504)	2.68651572
66	positive regulation of alpha-beta T cell activation (GO:0046635)	2.68225952
67	regulation of interleukin-4 production (GO:0032673)	2.67946231
68	regulation of action potential (GO:0098900)	2.67191923
69	drug catabolic process (GO:0042737)	2.66248645
70	mannosylation (GO:0097502)	2.66080039
71	lipopolysaccharide biosynthetic process (GO:0009103)	2.66048252
72	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.63340803
73	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	2.62272753
74	regulation of penile erection (GO:0060405)	2.62240965
75	multicellular organism reproduction (GO:0032504)	2.61525460
76	positive regulation of T-helper cell differentiation (GO:0045624)	2.60594201
77	positive regulation of alpha-beta T cell differentiation (GO:0046638)	2.60060998
78	RNA destabilization (GO:0050779)	2.59597921
79	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.57850828
80	positive regulation of neutrophil migration (GO:1902624)	2.57160177
81	positive regulation of neutrophil chemotaxis (GO:0090023)	2.57160177
82	positive regulation of cell size (GO:0045793)	2.55266121
83	regulation of neurotransmitter uptake (GO:0051580)	2.53204617
84	cullin deneddylation (GO:0010388)	2.52179672
85	regulation of meiosis I (GO:0060631)	2.51838738
86	regulation of sarcomere organization (GO:0060297)	2.51681465
87	peptidyl-threonine dephosphorylation (GO:0035970)	2.50975666
88	protein deneddylation (GO:0000338)	2.50840424
89	indolalkylamine metabolic process (GO:0006586)	2.50654637
90	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.50290693
91	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.49245122
92	ATP hydrolysis coupled proton transport (GO:0015991)	2.49245122
93	positive regulation of renal sodium excretion (GO:0035815)	2.48947396
94	positive regulation of meiosis (GO:0045836)	2.47979217
95	regulation of sensory perception of pain (GO:0051930)	2.47455455
96	regulation of sensory perception (GO:0051931)	2.47455455
97	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.46786559
98	positive regulation of activated T cell proliferation (GO:0042104)	2.46169121
99	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.45693594
100	T-helper cell differentiation (GO:0042093)	2.45693594

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.86903670
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.56746841
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.06147691
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.82648166
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.66852419
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.58059932
7	RUNX_20019798_ChIP-Seq_JUKART_Human	2.57258542
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.46486807
9	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.16958895
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06625447
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.06056737
12	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.01820478
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.01197319
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.94007469
15	HTT_18923047_ChIP-ChIP_STHdh_Human	1.88198797
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.87871111
17	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.82932894
18	SCL_19346495_ChIP-Seq_HPC-7_Human	1.81642018
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.80854762
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80259821
21	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.74984900
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.72187659
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68981082
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63395169
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.61562229
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.59016442
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.51273473
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50689242
29	AR_20517297_ChIP-Seq_VCAP_Human	1.48070126
30	AR_25329375_ChIP-Seq_VCAP_Human	1.45798358
31	P300_19829295_ChIP-Seq_ESCs_Human	1.42510197
32	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42394449
33	VDR_22108803_ChIP-Seq_LS180_Human	1.35434629
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32107024
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31299442
36	EWS_26573619_Chip-Seq_HEK293_Human	1.30063785
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.26360768
38	MYB_26560356_Chip-Seq_TH2_Human	1.25800294
39	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.25219146
40	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23090695
41	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23032364
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.22353902
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22267299
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.19928620
45	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19423092
46	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.17132994
47	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16694838
48	STAT3_23295773_ChIP-Seq_U87_Human	1.14594059
49	GATA3_26560356_Chip-Seq_TH2_Human	1.12611348
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12020047
51	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11883211
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.11798555
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11559109
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11048128
55	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.08684922
56	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06295765
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.05748164
58	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05575737
59	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.05428160
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.05412663
61	STAT1_20625510_ChIP-Seq_HELA_Human	1.05314572
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05273696
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05015878
64	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04964759
65	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.04823618
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04327069
67	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.03957272
68	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03930758
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.02756114
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02501285
71	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.01848324
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01515855
73	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.00995525
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.00274634
75	VDR_23849224_ChIP-Seq_CD4+_Human	0.99683279
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99436513
77	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.99064238
78	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.99036086
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96642098
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96642098
81	GATA3_27048872_Chip-Seq_THYMUS_Human	0.95881139
82	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.95791525
83	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.95777656
84	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94563495
85	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.93177598
86	TP53_18474530_ChIP-ChIP_U2OS_Human	0.92791530
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.92203478
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.91387470
89	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91083306
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.91083306
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.90993799
92	BCL6_27268052_Chip-Seq_Bcells_Human	0.90764624
93	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.89771248
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89694552
95	DROSHA_22980978_ChIP-Seq_HELA_Human	0.89622236
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88511153
97	CIITA_25753668_ChIP-Seq_RAJI_Human	0.88298360
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.87669032
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86568077
100	SMRT_27268052_Chip-Seq_Bcells_Human	0.86304793

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.99324497
2	MP0002009_preneoplasia	3.48206741
3	MP0005171_absent_coat_pigmentation	3.34237499
4	MP0010386_abnormal_urinary_bladder	3.03685341
5	MP0002933_joint_inflammation	2.93928323
6	MP0003879_abnormal_hair_cell	2.55867512
7	MP0002876_abnormal_thyroid_physiology	2.38123858
8	MP0003724_increased_susceptibility_to	2.26926918
9	MP0010368_abnormal_lymphatic_system	2.25387956
10	MP0002736_abnormal_nociception_after	2.17004935
11	MP0000372_irregular_coat_pigmentation	2.14861449
12	MP0005000_abnormal_immune_tolerance	2.10765623
13	MP0001968_abnormal_touch/_nociception	2.05382470
14	MP0001835_abnormal_antigen_presentation	2.01064798
15	MP0003436_decreased_susceptibility_to	1.95918755
16	MP0002166_altered_tumor_susceptibility	1.85911128
17	MP0001529_abnormal_vocalization	1.83557891
18	MP0003136_yellow_coat_color	1.74805522
19	MP0003880_abnormal_central_pattern	1.71576440
20	MP0005671_abnormal_response_to	1.70265750
21	MP0005310_abnormal_salivary_gland	1.68053134
22	MP0003718_maternal_effect	1.65171565
23	MP0003787_abnormal_imprinting	1.61071201
24	MP0001501_abnormal_sleep_pattern	1.60426764
25	MP0008877_abnormal_DNA_methylation	1.58185133
26	MP0001800_abnormal_humoral_immune	1.56514105
27	MP0002148_abnormal_hypersensitivity_rea	1.56442706
28	MP0005058_abnormal_lysosome_morphology	1.55243403
29	MP0005645_abnormal_hypothalamus_physiol	1.55157882
30	MP0006276_abnormal_autonomic_nervous	1.49783611
31	MP0009046_muscle_twitch	1.48787862
32	MP0002723_abnormal_immune_serum	1.43689509
33	MP0005551_abnormal_eye_electrophysiolog	1.40239153
34	MP0001765_abnormal_ion_homeostasis	1.40183653
35	MP0009745_abnormal_behavioral_response	1.36198409
36	MP0002006_tumorigenesis	1.34268512
37	MP0001533_abnormal_skeleton_physiology	1.31517025
38	MP0004019_abnormal_vitamin_homeostasis	1.30168706
39	MP0002254_reproductive_system_inflammat	1.25695848
40	MP0002452_abnormal_antigen_presenting	1.24594994
41	MP0003303_peritoneal_inflammation	1.23327807
42	MP0002909_abnormal_adrenal_gland	1.21991532
43	MP0005075_abnormal_melanosome_morpholog	1.20655537
44	MP0004484_altered_response_of	1.20318278
45	MP0009785_altered_susceptibility_to	1.19392482
46	MP0002638_abnormal_pupillary_reflex	1.19139182
47	MP0005367_renal/urinary_system_phenotyp	1.18098316
48	MP0000516_abnormal_urinary_system	1.18098316
49	MP0002064_seizures	1.17176008
50	MP0004147_increased_porphyrin_level	1.16359703
51	MP0008995_early_reproductive_senescence	1.16051236
52	MP0002090_abnormal_vision	1.14702726
53	MP0008875_abnormal_xenobiotic_pharmacok	1.11039512
54	MP0001819_abnormal_immune_cell	1.10522262
55	MP0002420_abnormal_adaptive_immunity	1.10284093
56	MP0005464_abnormal_platelet_physiology	1.07747949
57	MP0001502_abnormal_circadian_rhythm	1.06317532
58	MP0005167_abnormal_blood-brain_barrier	1.06018262
59	MP0003786_premature_aging	1.04460942
60	MP0003763_abnormal_thymus_physiology	1.02485001
61	MP0005365_abnormal_bile_salt	1.01834524
62	MP0002405_respiratory_system_inflammati	1.01739706
63	MP0009697_abnormal_copulation	1.01674318
64	MP0001664_abnormal_digestion	1.01624338
65	MP0002272_abnormal_nervous_system	1.01564863
66	MP0004742_abnormal_vestibular_system	1.00015417
67	MP0005395_other_phenotype	0.99201529
68	MP0001986_abnormal_taste_sensitivity	0.96339526
69	MP0002419_abnormal_innate_immunity	0.94767019
70	MP0001879_abnormal_lymphatic_vessel	0.94136163
71	MP0000569_abnormal_digit_pigmentation	0.93808885
72	MP0000383_abnormal_hair_follicle	0.92438916
73	MP0002102_abnormal_ear_morphology	0.90924673
74	MP0009643_abnormal_urine_homeostasis	0.90053518
75	MP0000026_abnormal_inner_ear	0.89668784
76	MP0000230_abnormal_systemic_arterial	0.87332619
77	MP0006036_abnormal_mitochondrial_physio	0.86292603
78	MP0003635_abnormal_synaptic_transmissio	0.83334028
79	MP0005025_abnormal_response_to	0.82230091
80	MP0006082_CNS_inflammation	0.81145859
81	MP0000613_abnormal_salivary_gland	0.80003638
82	MP0002572_abnormal_emotion/affect_behav	0.79562978
83	MP0001970_abnormal_pain_threshold	0.78447903
84	MP0001790_abnormal_immune_system	0.78430647
85	MP0005387_immune_system_phenotype	0.78430647
86	MP0001984_abnormal_olfaction	0.77966194
87	MP0006035_abnormal_mitochondrial_morpho	0.77450097
88	MP0001963_abnormal_hearing_physiology	0.77222455
89	MP0005646_abnormal_pituitary_gland	0.76768281
90	MP0000716_abnormal_immune_system	0.74637507
91	MP0010155_abnormal_intestine_physiology	0.73110524
92	MP0002735_abnormal_chemical_nociception	0.72464040
93	MP0002063_abnormal_learning/memory/cond	0.72007437
94	MP0002734_abnormal_mechanical_nocicepti	0.71888278
95	MP0001440_abnormal_grooming_behavior	0.71680468
96	MP0004859_abnormal_synaptic_plasticity	0.71630351
97	MP0001929_abnormal_gametogenesis	0.70854684
98	MP0005332_abnormal_amino_acid	0.70581762
99	MP0001486_abnormal_startle_reflex	0.70462353
100	MP0001845_abnormal_inflammatory_respons	0.69770779

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic islet-cell hyperplasia (HP:0004510)	7.31165758
2	Large for gestational age (HP:0001520)	6.52470615
3	Hypothermia (HP:0002045)	5.01353962
4	Hyperinsulinemic hypoglycemia (HP:0000825)	4.86925869
5	Abnormality of the pancreatic islet cells (HP:0006476)	4.83087516
6	Abnormality of endocrine pancreas physiology (HP:0012093)	4.83087516
7	Ketoacidosis (HP:0001993)	4.46663878
8	Insulin-resistant diabetes mellitus (HP:0000831)	4.31382955
9	Vacuolated lymphocytes (HP:0001922)	4.20174811
10	Intestinal atresia (HP:0011100)	4.16619627
11	Hyperglycemia (HP:0003074)	3.93434782
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.61589504
13	Severe combined immunodeficiency (HP:0004430)	3.57976455
14	Prominent metopic ridge (HP:0005487)	3.31293522
15	Stomatitis (HP:0010280)	3.17057151
16	Abnormality of the metopic suture (HP:0005556)	2.88797883
17	Type II lissencephaly (HP:0007260)	2.85930529
18	Molar tooth sign on MRI (HP:0002419)	2.82829198
19	Abnormality of midbrain morphology (HP:0002418)	2.82829198
20	Abnormal rod and cone electroretinograms (HP:0008323)	2.78075659
21	Pancreatic cysts (HP:0001737)	2.76551130
22	Cerebellar dysplasia (HP:0007033)	2.73363098
23	Broad face (HP:0000283)	2.68581685
24	Abnormality of proline metabolism (HP:0010907)	2.66498584
25	Hydroxyprolinuria (HP:0003080)	2.66498584
26	Abnormality of the prostate (HP:0008775)	2.60671670
27	Combined immunodeficiency (HP:0005387)	2.54412961
28	3-Methylglutaconic aciduria (HP:0003535)	2.52300092
29	Macroorchidism (HP:0000053)	2.50040113
30	Panhypogammaglobulinemia (HP:0003139)	2.48197694
31	Medial flaring of the eyebrow (HP:0010747)	2.47969004
32	Ketosis (HP:0001946)	2.47848982
33	Attenuation of retinal blood vessels (HP:0007843)	2.46711350
34	Chronic otitis media (HP:0000389)	2.44154044
35	Polydipsia (HP:0001959)	2.43888094
36	Abnormal drinking behavior (HP:0030082)	2.43888094
37	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.41050712
38	Abnormal protein N-linked glycosylation (HP:0012347)	2.41050712
39	Abnormal protein glycosylation (HP:0012346)	2.41050712
40	Abnormal glycosylation (HP:0012345)	2.41050712
41	Chronic diarrhea (HP:0002028)	2.40244027
42	Nephronophthisis (HP:0000090)	2.35771607
43	Abolished electroretinogram (ERG) (HP:0000550)	2.34545969
44	Decreased circulating renin level (HP:0003351)	2.33356794
45	True hermaphroditism (HP:0010459)	2.28359452
46	IgM deficiency (HP:0002850)	2.27769481
47	Type I transferrin isoform profile (HP:0003642)	2.23559843
48	IgG deficiency (HP:0004315)	2.22969243
49	Mutism (HP:0002300)	2.19850111
50	Occipital encephalocele (HP:0002085)	2.17426651
51	Gait imbalance (HP:0002141)	2.15630913
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14723329
53	Abnormality of dental color (HP:0011073)	2.13590236
54	Beaking of vertebral bodies (HP:0004568)	2.11877687
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.09358375
56	Follicular hyperkeratosis (HP:0007502)	2.06380510
57	Short tibia (HP:0005736)	2.06348527
58	Metaphyseal dysplasia (HP:0100255)	2.06067452
59	Congenital primary aphakia (HP:0007707)	2.03641498
60	Ulnar claw (HP:0001178)	2.00518298
61	Polyuria (HP:0000103)	1.97306629
62	Erythroderma (HP:0001019)	1.95016517
63	Cortical visual impairment (HP:0100704)	1.94956501
64	Epidermoid cyst (HP:0200040)	1.93817271
65	Gastrointestinal atresia (HP:0002589)	1.93292367
66	Congenital stationary night blindness (HP:0007642)	1.92343672
67	Pancreatic fibrosis (HP:0100732)	1.91280776
68	Ureteral obstruction (HP:0006000)	1.89119141
69	Hypsarrhythmia (HP:0002521)	1.89074602
70	Brittle hair (HP:0002299)	1.88610618
71	Insulin resistance (HP:0000855)	1.87874384
72	Abnormality of T cell number (HP:0011839)	1.87732534
73	Unilateral renal agenesis (HP:0000122)	1.86965501
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.86723651
75	Tinnitus (HP:0000360)	1.85063181
76	Elevated erythrocyte sedimentation rate (HP:0003565)	1.84882983
77	EEG with generalized epileptiform discharges (HP:0011198)	1.82071653
78	Thyroiditis (HP:0100646)	1.80011661
79	Retinal dysplasia (HP:0007973)	1.79396443
80	Recurrent corneal erosions (HP:0000495)	1.78536301
81	Absent eyebrow (HP:0002223)	1.77688647
82	Epileptiform EEG discharges (HP:0011182)	1.76920838
83	Abnormality of eosinophils (HP:0001879)	1.76530634
84	Mitochondrial inheritance (HP:0001427)	1.76490894
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74127526
86	Generalized aminoaciduria (HP:0002909)	1.73703353
87	Abnormal gallbladder morphology (HP:0012437)	1.72416427
88	Hyperventilation (HP:0002883)	1.71920467
89	Tubular atrophy (HP:0000092)	1.71489807
90	Hepatocellular necrosis (HP:0001404)	1.71113687
91	Progressive external ophthalmoplegia (HP:0000590)	1.70689370
92	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.65707266
93	Alopecia of scalp (HP:0002293)	1.65619253
94	Spondylolisthesis (HP:0003302)	1.65555657
95	Renal Fanconi syndrome (HP:0001994)	1.65527632
96	Parakeratosis (HP:0001036)	1.63198481
97	Methylmalonic aciduria (HP:0012120)	1.62573583
98	Cystic liver disease (HP:0006706)	1.62158440
99	Anterior segment dysgenesis (HP:0007700)	1.61643325
100	Progressive muscle weakness (HP:0003323)	1.61600767

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.84094382
2	TXK	4.60793132
3	STK39	3.24984906
4	TAF1	3.04402481
5	WNK4	2.83691963
6	MAP3K14	2.49444300
7	ADRBK2	2.29409285
8	TEC	2.00066184
9	SIK2	1.89617149
10	PBK	1.85758985
11	ITK	1.84765693
12	LIMK1	1.77933872
13	MAP2K2	1.74485345
14	MAP4K1	1.72413981
15	NUAK1	1.63475391
16	TESK1	1.56606636
17	SIK3	1.55182480
18	CAMK1D	1.55090258
19	MAPK13	1.53417206
20	KDR	1.53013475
21	IKBKE	1.51286370
22	IKBKB	1.49809132
23	NTRK2	1.49044782
24	CASK	1.47149365
25	VRK2	1.44132213
26	OXSR1	1.40680998
27	PIK3CG	1.36601211
28	BCKDK	1.31647896
29	EIF2AK2	1.31417766
30	MAP3K7	1.27454411
31	SYK	1.09843541
32	IRAK4	1.08494281
33	VRK1	1.08372248
34	GRK6	1.07894070
35	PAK6	1.07893971
36	TIE1	1.05378375
37	LATS1	1.04491759
38	CAMK2D	1.03356175
39	BTK	1.02315260
40	TBK1	0.97348611
41	IRAK1	0.95155198
42	MAPK11	0.93413494
43	TESK2	0.92650066
44	ZAK	0.88991576
45	GRK7	0.88147504
46	LCK	0.87283974
47	GRK5	0.86319143
48	BMPR2	0.85028238
49	INSRR	0.84740298
50	MAP3K5	0.83044226
51	MAP2K1	0.81441922
52	CSNK1G2	0.81152523
53	LYN	0.81030560
54	MARK3	0.80975552
55	INSR	0.80164586
56	GRK1	0.77516278
57	PAK3	0.77362455
58	SCYL2	0.74077687
59	PRKCQ	0.73934983
60	PIM2	0.73762791
61	BMX	0.73236128
62	CAMK4	0.72315202
63	CHUK	0.70776030
64	FRK	0.70467474
65	CSF1R	0.69381700
66	CAMK1	0.67344821
67	NEK6	0.66800762
68	MAP2K6	0.66580732
69	TRPM7	0.65048053
70	PKN1	0.64071769
71	PIM1	0.62958951
72	CSNK1G3	0.62716856
73	FES	0.62642746
74	BCR	0.59924021
75	PDK1	0.58040838
76	IGF1R	0.57796887
77	CSNK1A1L	0.57337291
78	IRAK2	0.56429921
79	ZAP70	0.55895473
80	CSK	0.55085275
81	PHKG1	0.53444098
82	PHKG2	0.53444098
83	RPS6KA4	0.53203042
84	ADRBK1	0.52030484
85	PLK4	0.51406323
86	PRKCE	0.51361187
87	STK10	0.51300627
88	MARK1	0.50876621
89	PRKAA2	0.44138421
90	KIT	0.41001189
91	EGFR	0.39300438
92	MAPK4	0.38268263
93	FGR	0.37860383
94	CAMK1G	0.37703535
95	MUSK	0.37630269
96	MAPKAPK2	0.36477868
97	PRKCI	0.36402598
98	PRKACB	0.35731837
99	PRKAA1	0.35575423
100	CSNK1G1	0.35113831

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.19038703
2	Basal transcription factors_Homo sapiens_hsa03022	3.68417294
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.50411241
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.28410522
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.62034739
6	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.25567763
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.13985382
8	Rheumatoid arthritis_Homo sapiens_hsa05323	2.05475521
9	Collecting duct acid secretion_Homo sapiens_hsa04966	1.94873329
10	Phototransduction_Homo sapiens_hsa04744	1.89339176
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.77641008
12	Type II diabetes mellitus_Homo sapiens_hsa04930	1.73598548
13	Butanoate metabolism_Homo sapiens_hsa00650	1.69776072
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.66461232
15	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.62543657
16	Insulin secretion_Homo sapiens_hsa04911	1.61764819
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.57529549
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.54474777
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.53200746
20	Sulfur metabolism_Homo sapiens_hsa00920	1.49636331
21	Circadian rhythm_Homo sapiens_hsa04710	1.49523329
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.46140030
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.41965781
24	Circadian entrainment_Homo sapiens_hsa04713	1.41910093
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.41009944
26	Regulation of autophagy_Homo sapiens_hsa04140	1.40872428
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.40313364
28	Olfactory transduction_Homo sapiens_hsa04740	1.39695002
29	Other glycan degradation_Homo sapiens_hsa00511	1.32556069
30	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.25081420
31	Allograft rejection_Homo sapiens_hsa05330	1.22374991
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.21205996
33	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.19800721
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.16910867
35	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.15924166
36	ABC transporters_Homo sapiens_hsa02010	1.14828029
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.11249986
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.09435583
39	Antigen processing and presentation_Homo sapiens_hsa04612	1.08479806
40	Oxidative phosphorylation_Homo sapiens_hsa00190	1.01496973
41	Renin secretion_Homo sapiens_hsa04924	0.97311210
42	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.93868703
43	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.93427616
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.90923941
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88843540
46	Morphine addiction_Homo sapiens_hsa05032	0.88650527
47	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.88176668
48	Asthma_Homo sapiens_hsa05310	0.87776155
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.85974804
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.83167808
51	Selenocompound metabolism_Homo sapiens_hsa00450	0.82592352
52	GABAergic synapse_Homo sapiens_hsa04727	0.82221542
53	Peroxisome_Homo sapiens_hsa04146	0.81276413
54	Lysosome_Homo sapiens_hsa04142	0.73505516
55	Cholinergic synapse_Homo sapiens_hsa04725	0.73401578
56	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.70588295
57	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70343908
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69118648
59	Salivary secretion_Homo sapiens_hsa04970	0.68338038
60	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.68024697
61	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.67689269
62	Amphetamine addiction_Homo sapiens_hsa05031	0.67439402
63	Taste transduction_Homo sapiens_hsa04742	0.66426842
64	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.65410741
65	Nicotine addiction_Homo sapiens_hsa05033	0.65381099
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65045933
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64746925
68	RNA polymerase_Homo sapiens_hsa03020	0.64005206
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.63413370
70	Measles_Homo sapiens_hsa05162	0.61303808
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.58010120
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57466671
73	Propanoate metabolism_Homo sapiens_hsa00640	0.56863122
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.55716697
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.54966410
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53655998
77	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.53285547
78	Leishmaniasis_Homo sapiens_hsa05140	0.51763451
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48787838
80	Serotonergic synapse_Homo sapiens_hsa04726	0.47153430
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.46793633
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.46566681
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44244110
84	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.43553555
85	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.41411374
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40322628
87	Linoleic acid metabolism_Homo sapiens_hsa00591	0.38980346
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38570979
89	Phagosome_Homo sapiens_hsa04145	0.38354939
90	Folate biosynthesis_Homo sapiens_hsa00790	0.38007507
91	Tuberculosis_Homo sapiens_hsa05152	0.37471389
92	Legionellosis_Homo sapiens_hsa05134	0.35545507
93	PPAR signaling pathway_Homo sapiens_hsa03320	0.35217091
94	Alzheimers disease_Homo sapiens_hsa05010	0.33330711
95	Cocaine addiction_Homo sapiens_hsa05030	0.32132754
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.30402059
97	Gastric acid secretion_Homo sapiens_hsa04971	0.29228209
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.28924869
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28148308
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.28064447

PTGER4P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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