PTGES

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)8.23012306
2bundle of His cell to Purkinje myocyte communication (GO:0086069)5.75673380
3hemidesmosome assembly (GO:0031581)4.96419587
4folic acid transport (GO:0015884)4.58578487
5regulation of transforming growth factor beta2 production (GO:0032909)4.54943165
6low-density lipoprotein particle clearance (GO:0034383)4.42450115
7cellular response to interferon-alpha (GO:0035457)4.36577295
8amyloid precursor protein catabolic process (GO:0042987)4.12753864
9intestinal epithelial cell development (GO:0060576)4.04193656
10regulation of water loss via skin (GO:0033561)3.93634321
11type B pancreatic cell proliferation (GO:0044342)3.73509493
12negative regulation of keratinocyte proliferation (GO:0010839)3.67835452
13regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.63732444
14establishment of skin barrier (GO:0061436)3.63426361
15amyloid precursor protein metabolic process (GO:0042982)3.62749642
16negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.56257370
17cell adhesion mediated by integrin (GO:0033627)3.56170330
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.53885390
19regulation of metalloenzyme activity (GO:0048552)3.53292347
20regulation of integrin-mediated signaling pathway (GO:2001044)3.48537743
21positive regulation of epidermal cell differentiation (GO:0045606)3.43218522
22positive regulation of heat generation (GO:0031652)3.42901970
23nuclear envelope reassembly (GO:0031468)3.41019712
24mitotic nuclear envelope reassembly (GO:0007084)3.41019712
25positive regulation of keratinocyte differentiation (GO:0045618)3.39755863
26folic acid metabolic process (GO:0046655)3.36204017
27dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.35054916
28amino sugar catabolic process (GO:0046348)3.34710706
29regulation of hippo signaling (GO:0035330)3.33330940
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32959615
31adhesion of symbiont to host (GO:0044406)3.29724938
32lung-associated mesenchyme development (GO:0060484)3.29420416
33epithelial cell-cell adhesion (GO:0090136)3.25748201
34wound healing, spreading of epidermal cells (GO:0035313)3.25493970
35positive regulation of epidermis development (GO:0045684)3.25019001
36protein autoprocessing (GO:0016540)3.22365114
37skin morphogenesis (GO:0043589)3.20129879
38polarized epithelial cell differentiation (GO:0030859)3.19535730
39protein retention in ER lumen (GO:0006621)3.17653475
40labyrinthine layer development (GO:0060711)3.13609842
41formation of translation preinitiation complex (GO:0001731)3.13215653
42epithelial cell differentiation involved in prostate gland development (GO:0060742)3.12568737
43androgen biosynthetic process (GO:0006702)3.12338323
44regulation of gonadotropin secretion (GO:0032276)3.12149451
45gap junction assembly (GO:0016264)3.10884058
46keratinocyte proliferation (GO:0043616)3.09241589
47* cyclooxygenase pathway (GO:0019371)3.08908096
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08536989
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08536989
50galactose catabolic process (GO:0019388)3.03419821
51mammary gland epithelial cell proliferation (GO:0033598)3.02687073
52branching involved in salivary gland morphogenesis (GO:0060445)2.98556045
53regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.98543213
54cytokine secretion (GO:0050663)2.95539993
55positive regulation of Cdc42 GTPase activity (GO:0043089)2.93692710
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92790328
57positive regulation by organism of defense response of other organism involved in symbiotic interact2.92790328
58modulation by symbiont of host immune response (GO:0052553)2.92790328
59positive regulation by symbiont of host defense response (GO:0052509)2.92790328
60modulation by symbiont of host defense response (GO:0052031)2.92790328
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92790328
62cellular copper ion homeostasis (GO:0006878)2.90381809
63estrogen biosynthetic process (GO:0006703)2.90246015
64regulation of fever generation (GO:0031620)2.88945075
65response to peptidoglycan (GO:0032494)2.87560977
66apoptotic cell clearance (GO:0043277)2.86224578
67desmosome organization (GO:0002934)2.85776400
68response to parathyroid hormone (GO:0071107)2.84814255
69GDP-mannose metabolic process (GO:0019673)2.84178823
70polyketide metabolic process (GO:0030638)2.82319785
71doxorubicin metabolic process (GO:0044598)2.82319785
72daunorubicin metabolic process (GO:0044597)2.82319785
73positive regulation of triglyceride biosynthetic process (GO:0010867)2.81081057
74regulation of apoptotic process involved in morphogenesis (GO:1902337)2.79987866
75regulation of keratinocyte proliferation (GO:0010837)2.79701649
76cell-substrate adherens junction assembly (GO:0007045)2.79607851
77focal adhesion assembly (GO:0048041)2.79607851
78membrane raft organization (GO:0031579)2.79360827
79regulation of cardioblast differentiation (GO:0051890)2.77231877
80regulation of translational fidelity (GO:0006450)2.76741743
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76107382
82multicellular organismal water homeostasis (GO:0050891)2.74064811
83C21-steroid hormone biosynthetic process (GO:0006700)2.74026142
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.72663821
85positive regulation of chemokine biosynthetic process (GO:0045080)2.71314845
86regulation of translational termination (GO:0006449)2.71056322
87negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.68909878
88protein maturation by protein folding (GO:0022417)2.67321959
89positive regulation of hair follicle development (GO:0051798)2.66369401
90positive regulation of hair cycle (GO:0042635)2.66369401
91nucleobase-containing small molecule interconversion (GO:0015949)2.65012707
92regulation of SMAD protein import into nucleus (GO:0060390)2.64877353
93hypotonic response (GO:0006971)2.63994343
94modified amino acid transport (GO:0072337)2.63654041
95antigen processing and presentation via MHC class Ib (GO:0002475)2.63390053
96negative regulation of stem cell proliferation (GO:2000647)2.63234416
97glucocorticoid biosynthetic process (GO:0006704)2.62945530
98L-serine transport (GO:0015825)2.59625699
99response to interferon-alpha (GO:0035455)2.59126829
100ribosome assembly (GO:0042255)2.59030326
101membrane budding (GO:0006900)2.58782219
102mannose metabolic process (GO:0006013)2.58721105
103regulation of podosome assembly (GO:0071801)2.58521154
104lipopolysaccharide biosynthetic process (GO:0009103)2.57306395
105morphogenesis of embryonic epithelium (GO:0016331)2.56417507
106protein hydroxylation (GO:0018126)2.55926919
107antigen processing and presentation of endogenous antigen (GO:0019883)2.55605509
108tRNA methylation (GO:0030488)2.55037263
109transcytosis (GO:0045056)2.54957864
110cellular response to arsenic-containing substance (GO:0071243)2.53015008
111activation of Rac GTPase activity (GO:0032863)2.51926065
112regulation of cellular amino acid metabolic process (GO:0006521)2.51659174
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.51507598
114regulation of transforming growth factor beta1 production (GO:0032908)2.50147338
115regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50045235
116positive regulation of p38MAPK cascade (GO:1900745)2.48909509
117regulation of keratinocyte differentiation (GO:0045616)2.48759009
118branching involved in mammary gland duct morphogenesis (GO:0060444)2.47653909
119proteasome assembly (GO:0043248)2.47055027
120norepinephrine metabolic process (GO:0042415)2.45183380
121positive regulation of SMAD protein import into nucleus (GO:0060391)2.45067180
122endothelial cell chemotaxis (GO:0035767)2.44523738
123regulation of triglyceride biosynthetic process (GO:0010866)2.44327289
124aminoglycoside antibiotic metabolic process (GO:0030647)2.43688263
125lung vasculature development (GO:0060426)2.43418174
126regulation of cholesterol storage (GO:0010885)2.42990539
127establishment of apical/basal cell polarity (GO:0035089)2.42597802
128regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.42169695
129wound healing, spreading of cells (GO:0044319)2.42142723
130ncRNA 3-end processing (GO:0043628)2.41431250
131Golgi transport vesicle coating (GO:0048200)2.41108327
132COPI coating of Golgi vesicle (GO:0048205)2.41108327
133hippo signaling (GO:0035329)2.40907218
134epidermis development (GO:0008544)2.40256963
135positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.39963067
136water homeostasis (GO:0030104)2.39892408
137nucleotide-sugar biosynthetic process (GO:0009226)2.39538781
138negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.39502471
139protein localization to endosome (GO:0036010)2.39397702
140positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38817184
141lung lobe morphogenesis (GO:0060463)2.38023975
142positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.37940338
143regulation of heat generation (GO:0031650)2.37378456
144cell differentiation involved in embryonic placenta development (GO:0060706)2.36733963
145response to vitamin D (GO:0033280)2.35825798
146response to manganese ion (GO:0010042)2.35544619
147fructose metabolic process (GO:0006000)2.35418600
148iron ion import (GO:0097286)2.35382498
149peptidyl-proline hydroxylation (GO:0019511)2.35343889
150chaperone mediated protein folding requiring cofactor (GO:0051085)2.35041845
151skin development (GO:0043588)2.34710774
152blastocyst development (GO:0001824)2.34426271
153regulation of mitochondrial translation (GO:0070129)2.34267792
154negative regulation of chondrocyte differentiation (GO:0032331)2.33956738
155hair cycle (GO:0042633)2.33880416
156molting cycle (GO:0042303)2.33880416
157keratinocyte development (GO:0003334)2.33346908
158regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.31160575
159anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.28206918
160branching involved in labyrinthine layer morphogenesis (GO:0060670)2.26402358
161cell-substrate junction assembly (GO:0007044)2.26248801
162signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.26215746
163signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.26215746
164signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.26215746
165Arp2/3 complex-mediated actin nucleation (GO:0034314)2.25925637
166DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.25838555
167regulation of membrane protein ectodomain proteolysis (GO:0051043)2.25331846
168signal transduction involved in DNA damage checkpoint (GO:0072422)2.24452420
169signal transduction involved in DNA integrity checkpoint (GO:0072401)2.24452420
170endodermal cell differentiation (GO:0035987)2.23322093
171regulation of histone H3-K27 methylation (GO:0061085)2.22586125
172sphingosine metabolic process (GO:0006670)2.22420746
173positive regulation of nitric oxide biosynthetic process (GO:0045429)2.21702682
174antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.21417290
175intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.20715420
176signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.20715420
177signal transduction involved in cell cycle checkpoint (GO:0072395)2.18808177
178positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.16651015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.27491662
2* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.77447308
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.33586104
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87021756
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.53405405
6SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.39939264
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.38727708
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.36290041
9STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.29449532
10* TRIM28_21343339_ChIP-Seq_HEK293_Human2.27387683
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.23153549
12* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.21700248
13CLOCK_20551151_ChIP-Seq_293T_Human2.19911688
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19776749
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.10867108
16ZNF263_19887448_ChIP-Seq_K562_Human2.09321450
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03025509
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.02702931
19* ESR2_21235772_ChIP-Seq_MCF-7_Human1.94823425
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91236962
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.88945369
22* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.84380423
23* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.84380423
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82920202
25AR_21909140_ChIP-Seq_LNCAP_Human1.76218264
26* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75374582
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75100830
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72893466
29* ATF3_27146783_Chip-Seq_COLON_Human1.70182234
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70066714
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70038367
32* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69006091
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.63978228
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62970601
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61834020
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60073235
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58510764
38ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.56786785
39SOX2_20726797_ChIP-Seq_SW620_Human1.56074207
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54355694
41EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.52904214
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52275202
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51565260
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.47000086
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46412876
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46222797
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45348648
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43846270
49RACK7_27058665_Chip-Seq_MCF-7_Human1.43800678
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43140389
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43140389
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43140389
53* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42264934
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41356936
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39884002
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38493274
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36947193
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.35920918
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.31003465
60* LXR_22292898_ChIP-Seq_THP-1_Human1.30928082
61HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30656668
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.30511147
63KLF5_25053715_ChIP-Seq_YYC3_Human1.29833434
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.29316943
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29057862
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28960577
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28071530
68* RUNX1_27514584_Chip-Seq_MCF-7_Human1.27632127
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27517071
70* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27443762
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.25192234
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24438249
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23976963
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20940432
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.19787854
76* ELF5_23300383_ChIP-Seq_T47D_Human1.19282439
77* GATA4_25053715_ChIP-Seq_YYC3_Human1.19179237
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18899469
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.18808605
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18697265
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.18617734
82NANOG_18692474_ChIP-Seq_MEFs_Mouse1.17717194
83TP53_22127205_ChIP-Seq_IMR90_Human1.17322268
84TFEB_21752829_ChIP-Seq_HELA_Human1.16856723
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16465045
86MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16427076
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15293662
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14156762
89SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11519147
90GATA6_25053715_ChIP-Seq_YYC3_Human1.11512987
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11086249
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.11012959
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09720199
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08469867
95CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06803621
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06685613
97NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06247149
98* TP63_22573176_ChIP-Seq_HFKS_Human1.05742315
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03995503
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03538662
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02702790
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01714575
103* SMC4_20622854_ChIP-Seq_HELA_Human1.00989046
104* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00796082
105CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00765197
106* GATA3_24758297_ChIP-Seq_MCF-7_Human1.00757313
107E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00385289
108GATA1_22025678_ChIP-Seq_K562_Human1.00331238
109* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98752271
110GABP_19822575_ChIP-Seq_HepG2_Human0.97971200
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97381029
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97255353
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96964860
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96738656
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96507935
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95402149
117GABP_17652178_ChIP-ChIP_JURKAT_Human0.94729375
118THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94265287
119* CJUN_26792858_Chip-Seq_BT549_Human0.93943868
120* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93663945
121* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93181120
122DCP1A_22483619_ChIP-Seq_HELA_Human0.93119679
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91158218
124P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90143709
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89186258
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88540792
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88386217
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87886456
129XRN2_22483619_ChIP-Seq_HELA_Human0.87696027
130JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86931351
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86774176
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86722906
133AHR_22903824_ChIP-Seq_MCF-7_Human0.86513848
134* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85474027
135BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84523034
136MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84312921
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84129080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.73416572
2MP0010352_gastrointestinal_tract_polyps3.33045791
3MP0005275_abnormal_skin_tensile3.24427305
4MP0000579_abnormal_nail_morphology3.09837626
5MP0003566_abnormal_cell_adhesion2.64234922
6MP0003705_abnormal_hypodermis_morpholog2.38755942
7MP0010234_abnormal_vibrissa_follicle2.35177423
8MP0004233_abnormal_muscle_weight2.26822232
9MP0002796_impaired_skin_barrier2.25433287
10MP0005023_abnormal_wound_healing2.24180505
11MP0009840_abnormal_foam_cell2.09270064
12MP0003693_abnormal_embryo_hatching2.02798322
13MP0005058_abnormal_lysosome_morphology1.97538667
14MP0001958_emphysema1.94726250
15MP0009053_abnormal_anal_canal1.89094541
16MP0002060_abnormal_skin_morphology1.85788197
17MP0001661_extended_life_span1.80397243
18MP0003303_peritoneal_inflammation1.76933941
19MP0004947_skin_inflammation1.72669134
20MP0000383_abnormal_hair_follicle1.72584072
21MP0003453_abnormal_keratinocyte_physiol1.72369106
22MP0002254_reproductive_system_inflammat1.72184545
23MP0001542_abnormal_bone_strength1.71466087
24MP0003941_abnormal_skin_development1.71035438
25MP0004272_abnormal_basement_membrane1.68601608
26MP0001216_abnormal_epidermal_layer1.66173752
27MP0005623_abnormal_meninges_morphology1.65285570
28MP0001756_abnormal_urination1.64694268
29MP0010678_abnormal_skin_adnexa1.64407842
30MP0000013_abnormal_adipose_tissue1.62574170
31MP0008260_abnormal_autophagy1.61821303
32MP0000427_abnormal_hair_cycle1.56992358
33MP0005076_abnormal_cell_differentiation1.54467818
34MP0003806_abnormal_nucleotide_metabolis1.54122262
35MP0000627_abnormal_mammary_gland1.48596816
36MP0004782_abnormal_surfactant_physiolog1.47706426
37MP0003191_abnormal_cellular_cholesterol1.47294015
38MP0010030_abnormal_orbit_morphology1.46132913
39MP0000678_abnormal_parathyroid_gland1.45759007
40MP0001533_abnormal_skeleton_physiology1.45375602
41MP0003186_abnormal_redox_activity1.42568585
42MP0000343_altered_response_to1.41209252
43MP0002234_abnormal_pharynx_morphology1.41123445
44MP0003448_altered_tumor_morphology1.40437134
45MP0005501_abnormal_skin_physiology1.39382515
46MP0005083_abnormal_biliary_tract1.37559121
47MP0004264_abnormal_extraembryonic_tissu1.36047634
48MP0008004_abnormal_stomach_pH1.35692174
49MP0003828_pulmonary_edema1.35046802
50MP0000750_abnormal_muscle_regeneration1.33683671
51MP0003300_gastrointestinal_ulcer1.30384833
52MP0004185_abnormal_adipocyte_glucose1.30227958
53MP0002098_abnormal_vibrissa_morphology1.26799271
54MP0009785_altered_susceptibility_to1.26655309
55MP0004957_abnormal_blastocyst_morpholog1.26515659
56MP0005666_abnormal_adipose_tissue1.26366580
57MP0003724_increased_susceptibility_to1.26276848
58MP0000003_abnormal_adipose_tissue1.25388691
59MP0002295_abnormal_pulmonary_circulatio1.25126998
60MP0000537_abnormal_urethra_morphology1.22668715
61MP0005164_abnormal_response_to1.21855316
62MP0001881_abnormal_mammary_gland1.19347546
63MP0009780_abnormal_chondrocyte_physiolo1.17478084
64MP0000566_synostosis1.15925487
65MP0003436_decreased_susceptibility_to1.14571705
66MP0002332_abnormal_exercise_endurance1.13072416
67MP0000377_abnormal_hair_follicle1.09584922
68MP0002166_altered_tumor_susceptibility1.08612863
69MP0003950_abnormal_plasma_membrane1.07861736
70MP0005451_abnormal_body_composition1.07415075
71MP0002006_tumorigenesis1.06703195
72MP0008875_abnormal_xenobiotic_pharmacok1.05471176
73MP0001348_abnormal_lacrimal_gland1.04022753
74MP0003111_abnormal_nucleus_morphology1.02382518
75MP0010386_abnormal_urinary_bladder1.01489286
76MP0000647_abnormal_sebaceous_gland0.99634124
77MP0006054_spinal_hemorrhage0.99250466
78MP0002998_abnormal_bone_remodeling0.99026925
79MP0003091_abnormal_cell_migration0.97646918
80MP0004019_abnormal_vitamin_homeostasis0.97523109
81MP0004858_abnormal_nervous_system0.97154633
82MP0005390_skeleton_phenotype0.97014155
83MP0005330_cardiomyopathy0.95851160
84MP0002168_other_aberrant_phenotype0.94949018
85MP0010771_integument_phenotype0.94524711
86MP0000858_altered_metastatic_potential0.93601582
87MP0003011_delayed_dark_adaptation0.93570260
88MP0005503_abnormal_tendon_morphology0.93460740
89MP0005197_abnormal_uvea_morphology0.92022722
90MP0000358_abnormal_cell_content/0.91554158
91MP0003045_fibrosis0.91347373
92MP0005257_abnormal_intraocular_pressure0.91328209
93MP0005395_other_phenotype0.91296708
94MP0005375_adipose_tissue_phenotype0.90134763
95MP0003718_maternal_effect0.90065343
96MP0009278_abnormal_bone_marrow0.87816460
97MP0001919_abnormal_reproductive_system0.87494695
98MP0001191_abnormal_skin_condition0.84551393
99MP0003936_abnormal_reproductive_system0.84274856
100MP0002136_abnormal_kidney_physiology0.84091483
101MP0010155_abnormal_intestine_physiology0.82968823
102MP0003315_abnormal_perineum_morphology0.82615987
103MP0009931_abnormal_skin_appearance0.81514616
104MP0002877_abnormal_melanocyte_morpholog0.79906301
105MP0000733_abnormal_muscle_development0.79214144
106MP0003786_premature_aging0.79128527
107MP0005670_abnormal_white_adipose0.77952225
108MP0005508_abnormal_skeleton_morphology0.77901026
109MP0001849_ear_inflammation0.76843041
110MP0001340_abnormal_eyelid_morphology0.76741333
111MP0001243_abnormal_dermal_layer0.76647157
112MP0001727_abnormal_embryo_implantation0.76314008
113MP0005310_abnormal_salivary_gland0.75697303
114* MP0002419_abnormal_innate_immunity0.75694702
115MP0009643_abnormal_urine_homeostasis0.75464868
116MP0005025_abnormal_response_to0.74019746
117MP0000467_abnormal_esophagus_morphology0.73205094
118MP0008775_abnormal_heart_ventricle0.73201902
119MP0010307_abnormal_tumor_latency0.72642321
120MP0002876_abnormal_thyroid_physiology0.72269568
121MP0000367_abnormal_coat/_hair0.72093218
122MP0000762_abnormal_tongue_morphology0.70718155
123MP0002909_abnormal_adrenal_gland0.70201061
124MP0004381_abnormal_hair_follicle0.70141046
125MP0009764_decreased_sensitivity_to0.69554680
126MP0005166_decreased_susceptibility_to0.69398232
127MP0002896_abnormal_bone_mineralization0.69033202
128MP0001873_stomach_inflammation0.68951860
129MP0005397_hematopoietic_system_phenotyp0.68623210
130MP0001545_abnormal_hematopoietic_system0.68623210
131MP0003795_abnormal_bone_structure0.67552069
132MP0009250_abnormal_appendicular_skeleto0.66750230
133MP0009379_abnormal_foot_pigmentation0.66354494
134MP0002133_abnormal_respiratory_system0.65280350
135MP0000490_abnormal_crypts_of0.64494074
136MP0008932_abnormal_embryonic_tissue0.64406361
137MP0003755_abnormal_palate_morphology0.63226877
138MP0005193_abnormal_anterior_eye0.62135667
139MP0005165_increased_susceptibility_to0.61364632

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.69894236
2Papilledema (HP:0001085)3.99287402
3Aortic aneurysm (HP:0004942)3.80501223
4Increased density of long bones (HP:0006392)3.74470379
5Facial diplegia (HP:0001349)3.67138734
6Hypotrichosis (HP:0001006)3.64856420
7Osteolytic defects of the phalanges of the hand (HP:0009771)3.64670708
8Osteolytic defects of the hand bones (HP:0009699)3.64670708
9Atrophic scars (HP:0001075)3.56824705
10Aortic dissection (HP:0002647)3.40071752
11Ankle contracture (HP:0006466)3.29816714
12Thick nail (HP:0001805)3.15566937
13Hypoplasia of dental enamel (HP:0006297)3.13712229
14Protrusio acetabuli (HP:0003179)3.03448247
15Abnormality of glycolipid metabolism (HP:0010969)3.01761309
16Abnormality of liposaccharide metabolism (HP:0010968)3.01761309
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.01761309
18Onycholysis (HP:0001806)3.01637500
19Abnormality of the distal phalanges of the toes (HP:0010182)3.00810259
20Alopecia of scalp (HP:0002293)3.00609269
21Brittle hair (HP:0002299)2.98557697
22Abnormal hair laboratory examination (HP:0003328)2.98319017
23Cervical subluxation (HP:0003308)2.96475573
24Short nail (HP:0001799)2.93031217
25Increased cerebral lipofuscin (HP:0011813)2.87602000
26Milia (HP:0001056)2.87377066
27Interstitial pulmonary disease (HP:0006530)2.83831588
28Reduced subcutaneous adipose tissue (HP:0003758)2.80765004
29Vacuolated lymphocytes (HP:0001922)2.78116048
30Myopathic facies (HP:0002058)2.76545746
31Abnormality of macrophages (HP:0004311)2.75409255
32Right ventricular cardiomyopathy (HP:0011663)2.72507565
33Fragile nails (HP:0001808)2.72048620
34Vertebral compression fractures (HP:0002953)2.69070217
35Amelogenesis imperfecta (HP:0000705)2.68726885
36Pustule (HP:0200039)2.68222278
37Pili torti (HP:0003777)2.61956225
38Abnormality of the umbilical cord (HP:0010881)2.57396359
39Plantar hyperkeratosis (HP:0007556)2.53005854
40Eczematoid dermatitis (HP:0000976)2.50823139
41Spinal cord compression (HP:0002176)2.49489421
42Distal lower limb muscle weakness (HP:0009053)2.47464943
43Ureteral duplication (HP:0000073)2.44529662
44Renal tubular acidosis (HP:0001947)2.44036418
45Nail dystrophy (HP:0008404)2.43712495
46Ridged nail (HP:0001807)2.42316973
47Trismus (HP:0000211)2.40875130
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.38710982
49Broad face (HP:0000283)2.37658672
50Follicular hyperkeratosis (HP:0007502)2.36838918
51Bilateral sensorineural hearing impairment (HP:0008619)2.34849213
52Tetraparesis (HP:0002273)2.34813615
53Advanced eruption of teeth (HP:0006288)2.33861603
54Entropion (HP:0000621)2.33557276
55Abnormality of nail color (HP:0100643)2.32116961
56Pterygium (HP:0001059)2.30022845
57Distal lower limb amyotrophy (HP:0008944)2.26625580
58Hypokinesia (HP:0002375)2.26531924
59Shallow orbits (HP:0000586)2.24332149
60Acanthosis nigricans (HP:0000956)2.19930495
61Blepharitis (HP:0000498)2.19587850
62Prolonged neonatal jaundice (HP:0006579)2.19511945
63Tibial bowing (HP:0002982)2.19384642
64Congenital, generalized hypertrichosis (HP:0004540)2.19324854
65Fused cervical vertebrae (HP:0002949)2.19024521
66Abnormal trabecular bone morphology (HP:0100671)2.16305387
67Bowed forearm bones (HP:0003956)2.14972215
68Bowing of the arm (HP:0006488)2.14972215
69Elbow flexion contracture (HP:0002987)2.14370448
70Ileus (HP:0002595)2.13631556
71Progressive visual loss (HP:0000529)2.10990147
72Choanal stenosis (HP:0000452)2.10626266
73Partial agenesis of the corpus callosum (HP:0001338)2.08474151
74Cerebral aneurysm (HP:0004944)2.06389400
75Ulnar bowing (HP:0003031)2.06182388
76Dry hair (HP:0011359)2.05657019
77Congenital ichthyosiform erythroderma (HP:0007431)2.04911708
78Abnormal blistering of the skin (HP:0008066)2.04843869
79Myocardial infarction (HP:0001658)2.03639089
80Difficulty climbing stairs (HP:0003551)2.03393908
81Sparse eyelashes (HP:0000653)1.99979771
82Mitral stenosis (HP:0001718)1.99756769
83Increased connective tissue (HP:0009025)1.99207668
84Dilatation of the ascending aorta (HP:0005111)1.98304420
85Selective tooth agenesis (HP:0001592)1.97655339
86Aplasia involving bones of the upper limbs (HP:0009823)1.97288240
87Aplasia of the phalanges of the hand (HP:0009802)1.97288240
88Aplasia involving bones of the extremities (HP:0009825)1.97288240
89Focal segmental glomerulosclerosis (HP:0000097)1.97140931
90Abnormality of carpal bone ossification (HP:0006257)1.95501530
91Hematochezia (HP:0002573)1.94206314
92Soft skin (HP:0000977)1.94057757
93Achilles tendon contracture (HP:0001771)1.94053949
94Palmoplantar hyperkeratosis (HP:0000972)1.93141245
95Coxa vara (HP:0002812)1.92931218
96Type 1 muscle fiber predominance (HP:0003803)1.92230783
97Peritonitis (HP:0002586)1.91922434
98Glomerulosclerosis (HP:0000096)1.90957776
99Oligodontia (HP:0000677)1.89814003
100Fibular aplasia (HP:0002990)1.89591561
101Nausea (HP:0002018)1.88844536
102Wormian bones (HP:0002645)1.88623956
103Systemic lupus erythematosus (HP:0002725)1.88192712
104Natal tooth (HP:0000695)1.88126735
105Aplasia cutis congenita (HP:0001057)1.87888535
106Fragile skin (HP:0001030)1.87836385
107Rough bone trabeculation (HP:0100670)1.87775638
108Popliteal pterygium (HP:0009756)1.87530597
109Hand muscle atrophy (HP:0009130)1.86954946
110Patent foramen ovale (HP:0001655)1.86844222
111Relative macrocephaly (HP:0004482)1.86513647
112Broad ribs (HP:0000885)1.86065443
113Prostate neoplasm (HP:0100787)1.85543367
114Cardiovascular calcification (HP:0011915)1.85439909
115Stenosis of the external auditory canal (HP:0000402)1.84856790
116Hypoplasia of the uterus (HP:0000013)1.84474254
117Radial bowing (HP:0002986)1.84455782
118Flattened epiphyses (HP:0003071)1.84393885
119Breast hypoplasia (HP:0003187)1.83984226
120Flat acetabular roof (HP:0003180)1.83559708
121Aplasia/Hypoplasia of the clavicles (HP:0006710)1.82998746
122Aneurysm (HP:0002617)1.82803553
123Lip pit (HP:0100267)1.82770704
124Poikiloderma (HP:0001029)1.82293462
125Palmar hyperkeratosis (HP:0010765)1.81217463
126Erythema (HP:0010783)1.81187326
127Hyperacusis (HP:0010780)1.81162921
128Vascular calcification (HP:0004934)1.80178857
129Esophageal varix (HP:0002040)1.79637527
130Short hallux (HP:0010109)1.79494545
131Micronodular cirrhosis (HP:0001413)1.79242780
132Short clavicles (HP:0000894)1.79034312
133Deviation of the thumb (HP:0009603)1.75367180
134Spinal muscular atrophy (HP:0007269)1.75346027
135Spinal rigidity (HP:0003306)1.74990846
136Dysostosis multiplex (HP:0000943)1.74779494
137Nemaline bodies (HP:0003798)1.74240840
138Glucose intolerance (HP:0000833)1.74012379
139Renal salt wasting (HP:0000127)1.73894454
140Insulin-resistant diabetes mellitus (HP:0000831)1.73812364
141Abnormal umbilical cord blood vessels (HP:0011403)1.72990303
142Single umbilical artery (HP:0001195)1.72990303
143Abnormality of the fetal cardiovascular system (HP:0010948)1.72990303
144Long foot (HP:0001833)1.72878437
145Premature loss of primary teeth (HP:0006323)1.72631750
146Abnormal ossification of hand bones (HP:0005921)1.72490578
147Hypoplastic pelvis (HP:0008839)1.70769290
148Aplasia/Hypoplasia of the hallux (HP:0008362)1.70394312
149Abnormality of molar (HP:0011077)1.70008320
150Abnormality of molar morphology (HP:0011070)1.70008320
151Anorexia (HP:0002039)1.69877900
152Woolly hair (HP:0002224)1.69738250
153Gastrointestinal dysmotility (HP:0002579)1.69668395
154Concave nail (HP:0001598)1.69158471
155Ankyloglossia (HP:0010296)1.68768494
156Hydroxyprolinuria (HP:0003080)1.68222638
157Abnormality of proline metabolism (HP:0010907)1.68222638
158Small epiphyses (HP:0010585)1.68164908
159Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.67400164
160Tongue fasciculations (HP:0001308)1.67370307
161Cheilitis (HP:0100825)1.66189279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.17069781
2IRAK33.46451372
3MYLK2.64690549
4WEE12.55151584
5TRIB32.51951249
6ERN12.48896102
7MAP3K32.23780152
8BUB12.19093109
9WNK42.12949314
10NME22.04915275
11STK391.99759833
12FER1.92301630
13MST41.91526631
14EPHA31.78359756
15MST1R1.71709126
16NTRK11.71053305
17TTN1.70380288
18AKT31.69897881
19FLT31.68206459
20LIMK11.67302772
21FRK1.62887236
22PIM21.53352229
23CAMK1D1.50322408
24DDR21.48873425
25TBK11.46964366
26MAP3K121.46851482
27PNCK1.45428295
28LATS11.43017125
29EPHB11.36958057
30RPS6KA41.35075560
31NLK1.33028003
32NME11.32057160
33RPS6KB21.28812615
34TESK11.24804149
35STK381.16605347
36LRRK21.11112002
37NEK91.10948429
38PDK21.09536183
39PAK41.08519537
40TSSK61.08475947
41SIK11.05566046
42STK31.04569513
43STK38L1.03402190
44MET1.03283148
45FGFR41.01801238
46ERBB41.01191683
47TYK20.98811240
48ZAP700.98565485
49BLK0.98402990
50VRK20.96893709
51NUAK10.96789146
52OXSR10.96543703
53PIK3CG0.96380197
54MAP3K90.96163506
55SMG10.95872834
56BRAF0.95642225
57PRPF4B0.94525951
58MUSK0.94289882
59PAK10.94036230
60EPHB20.93995769
61ZAK0.92493620
62PAK20.89022346
63BRSK20.87819305
64LATS20.87734920
65TTK0.87249197
66IKBKB0.86399556
67LMTK20.84654411
68MAP3K60.84579324
69EIF2AK10.84149978
70ICK0.83451259
71DMPK0.83242255
72BMX0.83204997
73RIPK10.81846064
74ILK0.81514558
75IKBKE0.80021162
76MAP3K110.77064186
77JAK30.74715036
78PDK30.74442633
79PDK40.74442633
80TESK20.73755822
81STK240.72691010
82PRKCI0.70745295
83MAP2K30.70491730
84PIM10.67552978
85MAP2K20.67280789
86PTK60.66839036
87PBK0.66427747
88MAPKAPK30.65731743
89IRAK40.64323555
90SCYL20.62821674
91AURKA0.62369558
92CAMK2G0.62292175
93ARAF0.61863829
94PTK20.61474017
95TRPM70.61197178
96PDGFRA0.61170709
97ABL20.59649223
98NEK10.59104154
99MAP3K20.58247401
100EIF2AK30.57641647
101STK100.57538626
102AURKB0.57330731
103MAP3K140.57266885
104KDR0.57121431
105TAOK10.55887822
106PRKD20.55828743
107GSK3A0.55798765
108STK160.55515589
109CDK80.55190311
110EIF2AK20.54804024
111MAP2K10.54498740
112TAOK20.54124673
113BRSK10.54107767
114PHKG10.53947776
115PHKG20.53947776
116NEK20.53636759
117JAK10.53468270
118ALK0.51189852
119FGFR30.50611770
120PDGFRB0.50000598
121MAP3K80.49927044
122CHUK0.48244778
123MAPKAPK20.48109902
124DAPK30.47897388
125MTOR0.47379959
126CDK60.46836657
127PRKG20.45840885
128IRAK10.45300785
129CAMK1G0.44866850
130CSK0.44467130
131ADRBK10.42612222
132MAPKAPK50.42553386
133CDK70.41758176
134TGFBR20.41465482
135GRK50.40657536
136AKT20.39569941
137CAMK2D0.35134142
138CDC42BPA0.33586669
139MAP2K70.33081716
140CAMK2B0.32550976
141BCKDK0.31883616
142RAF10.31450356
143PKN20.29074114
144PLK10.27588171
145SIK30.25720566
146MELK0.25704777

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.89677193
2Sulfur relay system_Homo sapiens_hsa041222.36125522
3Steroid biosynthesis_Homo sapiens_hsa001002.31704749
4Lysosome_Homo sapiens_hsa041422.25632087
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.22732493
6Folate biosynthesis_Homo sapiens_hsa007902.19846704
7Legionellosis_Homo sapiens_hsa051342.05016111
8ECM-receptor interaction_Homo sapiens_hsa045121.89228723
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.86997979
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85994212
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80194928
12Regulation of autophagy_Homo sapiens_hsa041401.78457766
13Small cell lung cancer_Homo sapiens_hsa052221.75294807
14Fructose and mannose metabolism_Homo sapiens_hsa000511.68447888
15Leishmaniasis_Homo sapiens_hsa051401.68185715
16Sulfur metabolism_Homo sapiens_hsa009201.67468698
17Malaria_Homo sapiens_hsa051441.65824437
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.63812294
19N-Glycan biosynthesis_Homo sapiens_hsa005101.60129799
20Other glycan degradation_Homo sapiens_hsa005111.59178494
21Ovarian steroidogenesis_Homo sapiens_hsa049131.57436089
22Fatty acid elongation_Homo sapiens_hsa000621.53180125
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52256893
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51603748
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.50770549
26Collecting duct acid secretion_Homo sapiens_hsa049661.50031559
27TNF signaling pathway_Homo sapiens_hsa046681.48987648
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47326976
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42364619
30Phenylalanine metabolism_Homo sapiens_hsa003601.42222839
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.40436042
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39033627
33Antigen processing and presentation_Homo sapiens_hsa046121.37144501
34Focal adhesion_Homo sapiens_hsa045101.36755533
35p53 signaling pathway_Homo sapiens_hsa041151.36543314
36Glutathione metabolism_Homo sapiens_hsa004801.36363890
37Amoebiasis_Homo sapiens_hsa051461.34660734
38Proteoglycans in cancer_Homo sapiens_hsa052051.33650638
39Nucleotide excision repair_Homo sapiens_hsa034201.32735306
40Shigellosis_Homo sapiens_hsa051311.32307276
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32169131
42Mineral absorption_Homo sapiens_hsa049781.30370060
43Pertussis_Homo sapiens_hsa051331.29239050
44Toxoplasmosis_Homo sapiens_hsa051451.28981486
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28220209
46Adherens junction_Homo sapiens_hsa045201.26810337
47Ribosome_Homo sapiens_hsa030101.26738752
48Pentose phosphate pathway_Homo sapiens_hsa000301.26508737
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.25814737
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.25322956
51Staphylococcus aureus infection_Homo sapiens_hsa051501.24125113
52Thyroid cancer_Homo sapiens_hsa052161.23739655
53Tight junction_Homo sapiens_hsa045301.18281855
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15779580
55Sphingolipid metabolism_Homo sapiens_hsa006001.13380055
56Influenza A_Homo sapiens_hsa051641.11503825
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11035895
58Hepatitis C_Homo sapiens_hsa051601.10900210
59Rheumatoid arthritis_Homo sapiens_hsa053231.09578539
60HIF-1 signaling pathway_Homo sapiens_hsa040661.09150220
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08849752
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.07803911
63Epstein-Barr virus infection_Homo sapiens_hsa051691.07074531
64Adipocytokine signaling pathway_Homo sapiens_hsa049201.06938531
65Apoptosis_Homo sapiens_hsa042101.06269150
66Oxidative phosphorylation_Homo sapiens_hsa001901.05434738
67Vitamin B6 metabolism_Homo sapiens_hsa007501.03545263
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02902820
69Tuberculosis_Homo sapiens_hsa051521.00100020
70RNA polymerase_Homo sapiens_hsa030200.97770571
71Base excision repair_Homo sapiens_hsa034100.97691319
72Phagosome_Homo sapiens_hsa041450.97439349
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96492863
74Biosynthesis of amino acids_Homo sapiens_hsa012300.95731510
75Salmonella infection_Homo sapiens_hsa051320.95145401
76Bladder cancer_Homo sapiens_hsa052190.94777090
77Fatty acid biosynthesis_Homo sapiens_hsa000610.94379838
78Hippo signaling pathway_Homo sapiens_hsa043900.93993818
79RNA transport_Homo sapiens_hsa030130.91038935
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89532506
81Hedgehog signaling pathway_Homo sapiens_hsa043400.89503813
82* Arachidonic acid metabolism_Homo sapiens_hsa005900.88493569
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86686314
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84916069
85Measles_Homo sapiens_hsa051620.84061430
86Renin-angiotensin system_Homo sapiens_hsa046140.83847150
87Prostate cancer_Homo sapiens_hsa052150.82613872
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82387208
89Herpes simplex infection_Homo sapiens_hsa051680.81619490
90Osteoclast differentiation_Homo sapiens_hsa043800.81401637
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.80892902
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80620583
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79670105
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.79292088
95Caffeine metabolism_Homo sapiens_hsa002320.78904306
96DNA replication_Homo sapiens_hsa030300.78860905
97Galactose metabolism_Homo sapiens_hsa000520.78440247
98Vitamin digestion and absorption_Homo sapiens_hsa049770.78228316
99MicroRNAs in cancer_Homo sapiens_hsa052060.77930265
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77147523
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76735819
102Pyruvate metabolism_Homo sapiens_hsa006200.76607510
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74703526
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69506014
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69395977
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68554042
107Endocytosis_Homo sapiens_hsa041440.67417912
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67030183
109Tyrosine metabolism_Homo sapiens_hsa003500.66710483
110Chemical carcinogenesis_Homo sapiens_hsa052040.66406270
111Huntingtons disease_Homo sapiens_hsa050160.65744539
112PPAR signaling pathway_Homo sapiens_hsa033200.65661753
113* Metabolic pathways_Homo sapiens_hsa011000.65004399
114Carbon metabolism_Homo sapiens_hsa012000.62189663
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61238335
116Alzheimers disease_Homo sapiens_hsa050100.59758470
117Glycerolipid metabolism_Homo sapiens_hsa005610.59317411
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.59251437
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59118839
120Vibrio cholerae infection_Homo sapiens_hsa051100.56472260
121Basal cell carcinoma_Homo sapiens_hsa052170.56169704
122Pathways in cancer_Homo sapiens_hsa052000.55863616
123Pyrimidine metabolism_Homo sapiens_hsa002400.55838629
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55022793
125TGF-beta signaling pathway_Homo sapiens_hsa043500.54899028
126Acute myeloid leukemia_Homo sapiens_hsa052210.53842890
127Chronic myeloid leukemia_Homo sapiens_hsa052200.53484335
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52398299
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52354595
130AMPK signaling pathway_Homo sapiens_hsa041520.52105662
131HTLV-I infection_Homo sapiens_hsa051660.51480587
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50356565
133Synaptic vesicle cycle_Homo sapiens_hsa047210.50046866
134beta-Alanine metabolism_Homo sapiens_hsa004100.48761339
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48281015
136mTOR signaling pathway_Homo sapiens_hsa041500.47919417
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.47483576
138Protein digestion and absorption_Homo sapiens_hsa049740.47400453
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47388112
140Insulin resistance_Homo sapiens_hsa049310.47317704
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.47251880
142Hematopoietic cell lineage_Homo sapiens_hsa046400.47194172
143Parkinsons disease_Homo sapiens_hsa050120.46664104
144Hepatitis B_Homo sapiens_hsa051610.45651751
145Renal cell carcinoma_Homo sapiens_hsa052110.44873206
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44681469
147Graft-versus-host disease_Homo sapiens_hsa053320.44275132
148Mismatch repair_Homo sapiens_hsa034300.43703802
149Homologous recombination_Homo sapiens_hsa034400.43135169
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40926859
151Arginine and proline metabolism_Homo sapiens_hsa003300.37111280
152Basal transcription factors_Homo sapiens_hsa030220.36982476
153Purine metabolism_Homo sapiens_hsa002300.36703666
154Arginine biosynthesis_Homo sapiens_hsa002200.36581959
155Pancreatic cancer_Homo sapiens_hsa052120.35850361

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