PTGES3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.90605926
2CENP-A containing nucleosome assembly (GO:0034080)4.82590815
3centriole assembly (GO:0098534)4.82291052
4chromatin remodeling at centromere (GO:0031055)4.69422003
5DNA unwinding involved in DNA replication (GO:0006268)4.69182341
6nuclear pore organization (GO:0006999)4.67685375
7IMP biosynthetic process (GO:0006188)4.65677505
8mitotic metaphase plate congression (GO:0007080)4.58318254
9protein localization to chromosome, centromeric region (GO:0071459)4.51484063
10nuclear pore complex assembly (GO:0051292)4.47188286
11purine nucleobase biosynthetic process (GO:0009113)4.46250503
12DNA replication checkpoint (GO:0000076)4.44401269
13DNA replication initiation (GO:0006270)4.43374919
14kinetochore organization (GO:0051383)4.40362011
15sister chromatid segregation (GO:0000819)4.37846921
16DNA strand elongation involved in DNA replication (GO:0006271)4.28979121
17telomere maintenance via semi-conservative replication (GO:0032201)4.23125571
18nucleobase biosynthetic process (GO:0046112)4.21797440
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.18301118
20meiotic chromosome segregation (GO:0045132)4.14452677
21mitotic sister chromatid cohesion (GO:0007064)4.13141502
22DNA strand elongation (GO:0022616)4.09212424
23telomere maintenance via recombination (GO:0000722)4.07158538
24establishment of chromosome localization (GO:0051303)4.00379252
25IMP metabolic process (GO:0046040)3.97250676
26metaphase plate congression (GO:0051310)3.96436935
27ribosome assembly (GO:0042255)3.93554160
28DNA replication-independent nucleosome organization (GO:0034724)3.89379392
29DNA replication-independent nucleosome assembly (GO:0006336)3.89379392
30mitotic recombination (GO:0006312)3.88283818
31cullin deneddylation (GO:0010388)3.82869621
32DNA topological change (GO:0006265)3.79689779
33establishment of viral latency (GO:0019043)3.77023592
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.75778307
35kinetochore assembly (GO:0051382)3.74668155
36pore complex assembly (GO:0046931)3.73841654
37histone exchange (GO:0043486)3.71983096
38negative regulation of chromosome segregation (GO:0051985)3.61803589
39protein deneddylation (GO:0000338)3.60567656
40ribosome biogenesis (GO:0042254)3.59431829
41regulation of chromosome segregation (GO:0051983)3.58370339
42negative regulation of mitotic sister chromatid separation (GO:2000816)3.58202326
43negative regulation of sister chromatid segregation (GO:0033046)3.58202326
44negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.58202326
45negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.58202326
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.58202326
47mitotic spindle checkpoint (GO:0071174)3.56584177
48regulation of double-strand break repair via homologous recombination (GO:0010569)3.56536213
49maturation of 5.8S rRNA (GO:0000460)3.52652455
50deoxyribonucleotide biosynthetic process (GO:0009263)3.51626690
51mitotic spindle assembly checkpoint (GO:0007094)3.46296476
52proteasome assembly (GO:0043248)3.46148765
53attachment of spindle microtubules to kinetochore (GO:0008608)3.45386970
54non-recombinational repair (GO:0000726)3.45340304
55double-strand break repair via nonhomologous end joining (GO:0006303)3.45340304
56spindle assembly checkpoint (GO:0071173)3.44544207
57DNA ligation (GO:0006266)3.43760430
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.42832951
59transcription from RNA polymerase I promoter (GO:0006360)3.42013016
60telomere maintenance via telomere lengthening (GO:0010833)3.41958069
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41034221
62regulation of mitotic spindle checkpoint (GO:1903504)3.41034221
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.40836511
64rRNA modification (GO:0000154)3.39530705
65protein K6-linked ubiquitination (GO:0085020)3.38043955
66transcription initiation from RNA polymerase I promoter (GO:0006361)3.36408295
67transcription-coupled nucleotide-excision repair (GO:0006283)3.34593070
68regulation of mitotic sister chromatid segregation (GO:0033047)3.34028832
69regulation of sister chromatid segregation (GO:0033045)3.34028832
70regulation of mitotic sister chromatid separation (GO:0010965)3.34028832
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31841957
72protein complex localization (GO:0031503)3.30384737
73protein localization to kinetochore (GO:0034501)3.30325072
74mitotic nuclear envelope disassembly (GO:0007077)3.29707951
75regulation of nuclear cell cycle DNA replication (GO:0033262)3.27961401
76viral mRNA export from host cell nucleus (GO:0046784)3.27804524
77positive regulation of chromosome segregation (GO:0051984)3.27254104
78regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.26510161
79DNA replication-dependent nucleosome organization (GO:0034723)3.26168223
80DNA replication-dependent nucleosome assembly (GO:0006335)3.26168223
81centriole replication (GO:0007099)3.24717572
827-methylguanosine mRNA capping (GO:0006370)3.24235706
83L-serine metabolic process (GO:0006563)3.24231092
847-methylguanosine RNA capping (GO:0009452)3.22243564
85RNA capping (GO:0036260)3.22243564
86protein localization to chromosome (GO:0034502)3.18327658
87G1/S transition of mitotic cell cycle (GO:0000082)3.17522050
88cell cycle G1/S phase transition (GO:0044843)3.17522050
89regulation of spindle organization (GO:0090224)3.17401845
90regulation of sister chromatid cohesion (GO:0007063)3.15203447
91deoxyribose phosphate biosynthetic process (GO:0046385)3.13807624
922-deoxyribonucleotide biosynthetic process (GO:0009265)3.13807624
93tRNA aminoacylation for protein translation (GO:0006418)3.13403862
94negative regulation of mRNA processing (GO:0050686)3.12884778
95regulation of mitotic spindle organization (GO:0060236)3.10724971
96negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.08670029
97termination of RNA polymerase I transcription (GO:0006363)3.08033594
98mitotic chromosome condensation (GO:0007076)3.07321893
99DNA double-strand break processing (GO:0000729)3.05789828
100amino acid activation (GO:0043038)3.04815707
101tRNA aminoacylation (GO:0043039)3.04815707
102rRNA methylation (GO:0031167)3.04419655
103negative regulation of RNA splicing (GO:0033119)3.03604254
104termination of RNA polymerase II transcription (GO:0006369)3.03318130
105regulation of DNA endoreduplication (GO:0032875)3.02845616
106regulation of helicase activity (GO:0051095)3.01106671
107DNA-dependent DNA replication (GO:0006261)2.99461433
108ribosomal small subunit assembly (GO:0000028)2.99212744
109transcription elongation from RNA polymerase I promoter (GO:0006362)2.97693160
110membrane disassembly (GO:0030397)2.96804755
111nuclear envelope disassembly (GO:0051081)2.96804755
112DNA damage response, detection of DNA damage (GO:0042769)2.95890319
113spliceosomal snRNP assembly (GO:0000387)2.95350859
114folic acid-containing compound biosynthetic process (GO:0009396)2.94948516
115cellular protein complex localization (GO:0034629)2.94382077
116histone H2A acetylation (GO:0043968)2.93479605
117negative regulation of mRNA metabolic process (GO:1903312)2.93318455
118negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93239314
119negative regulation of ligase activity (GO:0051352)2.93239314
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93176012
121deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89247976
122anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87699227
123* DNA replication (GO:0006260)2.87569688
124spindle checkpoint (GO:0031577)2.85781828
125negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85314065
126positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84966812
127maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84606118
128mismatch repair (GO:0006298)2.84392921
129regulation of centriole replication (GO:0046599)2.82978414
130microtubule depolymerization (GO:0007019)2.82503585
131mitotic cell cycle (GO:0000278)2.80684618
132chromosome segregation (GO:0007059)2.79415485
133regulation of centrosome cycle (GO:0046605)2.79411442
134replication fork processing (GO:0031297)2.78967330
135nucleobase-containing small molecule interconversion (GO:0015949)2.77855206
136guanosine-containing compound biosynthetic process (GO:1901070)2.77717340
137termination of RNA polymerase III transcription (GO:0006386)2.76974862
138transcription elongation from RNA polymerase III promoter (GO:0006385)2.76974862
139mitotic sister chromatid segregation (GO:0000070)2.75705085
140regulation of transcription from RNA polymerase I promoter (GO:0006356)2.75143826
141transcription elongation from RNA polymerase II promoter (GO:0006368)2.74181211
142pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73959360
143somatic hypermutation of immunoglobulin genes (GO:0016446)2.73244667
144somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73244667
145positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.73072962
146positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.73072962
147positive regulation of mitotic sister chromatid separation (GO:1901970)2.73072962
148formation of translation preinitiation complex (GO:0001731)2.72793274
149regulation of mitotic metaphase/anaphase transition (GO:0030071)2.71770067
150pseudouridine synthesis (GO:0001522)2.71722817
151ATP-dependent chromatin remodeling (GO:0043044)2.71018207

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.73651858
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26138701
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.94199258
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.60060359
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.28009893
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20544932
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.09174646
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.01244580
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86193045
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82022655
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68199408
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61613280
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51003637
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46858991
15ELK1_19687146_ChIP-ChIP_HELA_Human2.46440106
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44750794
17AR_21909140_ChIP-Seq_LNCAP_Human2.39998150
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39958498
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37942755
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35011560
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.28211539
22VDR_23849224_ChIP-Seq_CD4+_Human2.25362453
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24110094
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22780478
25* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22718913
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21442536
27* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18105415
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16514658
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14571100
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05864781
31E2F1_21310950_ChIP-Seq_MCF-7_Human2.04706728
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00391656
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93783417
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.92671107
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.90519031
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.88837854
37* DCP1A_22483619_ChIP-Seq_HELA_Human1.86578447
38FOXP3_21729870_ChIP-Seq_TREG_Human1.85769538
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80745729
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77922058
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74676843
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70301764
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70213524
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66174550
45* XRN2_22483619_ChIP-Seq_HELA_Human1.65981008
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.61073283
47TTF2_22483619_ChIP-Seq_HELA_Human1.60553841
48GABP_19822575_ChIP-Seq_HepG2_Human1.57316552
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54064308
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50189539
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.49805996
52* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49606016
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48414263
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.46941541
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43611562
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42875476
57* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35791321
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33732820
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29696823
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25487707
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24978212
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18049142
63CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15145762
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13105068
65MYC_18940864_ChIP-ChIP_HL60_Human1.11177425
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.08893645
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07549374
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07009066
69* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05800398
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.05582320
71* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04577597
72ZNF263_19887448_ChIP-Seq_K562_Human1.03265018
73EWS_26573619_Chip-Seq_HEK293_Human1.01668517
74KDM5A_27292631_Chip-Seq_BREAST_Human1.01629211
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00279079
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99759969
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98222122
78NANOG_21062744_ChIP-ChIP_HESCs_Human0.97797438
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96595479
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94842950
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94842950
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94842950
83IRF1_19129219_ChIP-ChIP_H3396_Human0.94026699
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92159798
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91588472
86* CHD1_26751641_Chip-Seq_LNCaP_Human0.91363873
87* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88053440
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87931304
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87717753
90* CLOCK_20551151_ChIP-Seq_293T_Human0.87144877
91CIITA_25753668_ChIP-Seq_RAJI_Human0.85532036
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.84834949
93* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84527470
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84323164
95TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83857446
96* SOX17_20123909_ChIP-Seq_XEN_Mouse0.82221652
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82114010
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.82104605
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81993045
100KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80860031
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80712637
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.80339282
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79483685
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79388630
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78219125
106* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77639261
107* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76359276
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.75500820
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75054217
110GATA4_21415370_ChIP-Seq_HL-1_Mouse0.74736082
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74583167
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74357780
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73742837
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73555816
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71861682
116TFEB_21752829_ChIP-Seq_HELA_Human0.70690555
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69155456
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.68613625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.48707339
2MP0008057_abnormal_DNA_replication4.46871077
3MP0010094_abnormal_chromosome_stability4.21632637
4MP0008058_abnormal_DNA_repair3.52441309
5MP0008007_abnormal_cellular_replicative3.47769597
6MP0003077_abnormal_cell_cycle3.31296325
7MP0003123_paternal_imprinting3.24803580
8MP0004957_abnormal_blastocyst_morpholog3.22699627
9MP0003111_abnormal_nucleus_morphology3.14012423
10MP0000566_synostosis2.65080399
11MP0008877_abnormal_DNA_methylation2.58093588
12MP0003786_premature_aging2.55686234
13MP0008932_abnormal_embryonic_tissue2.50898351
14MP0009697_abnormal_copulation2.49654722
15MP0003315_abnormal_perineum_morphology2.15863934
16MP0005367_renal/urinary_system_phenotyp2.12614647
17MP0000516_abnormal_urinary_system2.12614647
18MP0003121_genomic_imprinting2.08759918
19MP0002396_abnormal_hematopoietic_system2.04226729
20MP0002160_abnormal_reproductive_system1.89804247
21MP0005408_hypopigmentation1.88146221
22MP0003718_maternal_effect1.87093113
23MP0009672_abnormal_birth_weight1.86432051
24MP0003186_abnormal_redox_activity1.81183232
25MP0003221_abnormal_cardiomyocyte_apopto1.76980213
26MP0010234_abnormal_vibrissa_follicle1.76169264
27* MP0000350_abnormal_cell_proliferation1.68391230
28MP0004808_abnormal_hematopoietic_stem1.64663868
29MP0003941_abnormal_skin_development1.56215099
30MP0001730_embryonic_growth_arrest1.51174899
31MP0009053_abnormal_anal_canal1.48783692
32MP0006035_abnormal_mitochondrial_morpho1.47107117
33MP0006292_abnormal_olfactory_placode1.44978077
34MP0001119_abnormal_female_reproductive1.44745538
35MP0003806_abnormal_nucleotide_metabolis1.41179495
36MP0003787_abnormal_imprinting1.39734302
37MP0001545_abnormal_hematopoietic_system1.39725983
38MP0005397_hematopoietic_system_phenotyp1.39725983
39MP0005389_reproductive_system_phenotype1.37313053
40MP0001188_hyperpigmentation1.37151976
41MP0001672_abnormal_embryogenesis/_devel1.33469390
42MP0005380_embryogenesis_phenotype1.33469390
43MP0002163_abnormal_gland_morphology1.31986024
44MP0002210_abnormal_sex_determination1.31621883
45MP0000358_abnormal_cell_content/1.27836258
46MP0000537_abnormal_urethra_morphology1.27177920
47MP0003567_abnormal_fetal_cardiomyocyte1.25033304
48MP0003943_abnormal_hepatobiliary_system1.24971820
49MP0005394_taste/olfaction_phenotype1.23345508
50MP0005499_abnormal_olfactory_system1.23345508
51MP0001986_abnormal_taste_sensitivity1.20499919
52MP0009703_decreased_birth_body1.20475550
53MP0003984_embryonic_growth_retardation1.19713094
54MP0002132_abnormal_respiratory_system1.18094057
55MP0000015_abnormal_ear_pigmentation1.17847225
56MP0001697_abnormal_embryo_size1.17635451
57MP0002088_abnormal_embryonic_growth/wei1.15510287
58MP0010030_abnormal_orbit_morphology1.15387147
59MP0010307_abnormal_tumor_latency1.11946458
60MP0000490_abnormal_crypts_of1.11035388
61MP0002697_abnormal_eye_size1.10221734
62MP0000313_abnormal_cell_death1.08859077
63MP0002233_abnormal_nose_morphology1.07534083
64MP0005075_abnormal_melanosome_morpholog1.07219149
65MP0006036_abnormal_mitochondrial_physio1.07136147
66MP0003890_abnormal_embryonic-extraembry1.02759265
67MP0004147_increased_porphyrin_level1.00914873
68MP0005623_abnormal_meninges_morphology1.00732959
69MP0001929_abnormal_gametogenesis0.98903056
70MP0001145_abnormal_male_reproductive0.97226773
71MP0000653_abnormal_sex_gland0.95752840
72MP0002938_white_spotting0.95595509
73MP0001919_abnormal_reproductive_system0.94646319
74MP0002751_abnormal_autonomic_nervous0.94634851
75MP0005384_cellular_phenotype0.94074777
76MP0010352_gastrointestinal_tract_polyps0.92942362
77MP0000647_abnormal_sebaceous_gland0.92306277
78MP0002009_preneoplasia0.90253323
79MP0003861_abnormal_nervous_system0.89575676
80MP0002876_abnormal_thyroid_physiology0.88635222
81MP0002080_prenatal_lethality0.88145600
82MP0002086_abnormal_extraembryonic_tissu0.87671571
83MP0002019_abnormal_tumor_incidence0.87193588
84MP0003937_abnormal_limbs/digits/tail_de0.87055617
85MP0002085_abnormal_embryonic_tissue0.86889662
86MP0000049_abnormal_middle_ear0.86686879
87MP0006072_abnormal_retinal_apoptosis0.86526267
88* MP0004197_abnormal_fetal_growth/weight/0.86215971
89MP0001346_abnormal_lacrimal_gland0.86027200
90MP0008260_abnormal_autophagy0.85911871
91MP0002092_abnormal_eye_morphology0.85547795
92* MP0005501_abnormal_skin_physiology0.84575708
93MP0000372_irregular_coat_pigmentation0.83510714
94MP0003942_abnormal_urinary_system0.82031415
95MP0001727_abnormal_embryo_implantation0.80430025
96MP0001186_pigmentation_phenotype0.79608604
97MP0005621_abnormal_cell_physiology0.79177137
98MP0003122_maternal_imprinting0.78845186
99MP0003763_abnormal_thymus_physiology0.78224244
100MP0001542_abnormal_bone_strength0.77836191
101MP0008789_abnormal_olfactory_epithelium0.77565032
102MP0002090_abnormal_vision0.77399274
103MP0004233_abnormal_muscle_weight0.76723147
104MP0004264_abnormal_extraembryonic_tissu0.76568595
105MP0001286_abnormal_eye_development0.76496252
106MP0002877_abnormal_melanocyte_morpholog0.76230760
107* MP0002796_impaired_skin_barrier0.73566262
108MP0003698_abnormal_male_reproductive0.72935893
109MP0003936_abnormal_reproductive_system0.72883275
110MP0000579_abnormal_nail_morphology0.72606304
111MP0002234_abnormal_pharynx_morphology0.72557349
112MP0003119_abnormal_digestive_system0.72299521
113MP0002161_abnormal_fertility/fecundity0.71950835
114MP0002277_abnormal_respiratory_mucosa0.71802385
115MP0002095_abnormal_skin_pigmentation0.71381591
116MP0001764_abnormal_homeostasis0.71272700
117MP0006054_spinal_hemorrhage0.70233157
118MP0001293_anophthalmia0.69684086
119MP0009333_abnormal_splenocyte_physiolog0.68727296
120MP0002084_abnormal_developmental_patter0.68377648
121MP0005266_abnormal_metabolism0.67758837
122MP0004185_abnormal_adipocyte_glucose0.67737519
123MP0005187_abnormal_penis_morphology0.66805399
124MP0008995_early_reproductive_senescence0.66509590
125MP0003699_abnormal_female_reproductive0.65822780
126MP0005248_abnormal_Harderian_gland0.64354127
127MP0000762_abnormal_tongue_morphology0.64322386
128MP0003385_abnormal_body_wall0.63337053
129MP0002148_abnormal_hypersensitivity_rea0.63096719
130MP0005076_abnormal_cell_differentiation0.62731825
131MP0003755_abnormal_palate_morphology0.61800668
132MP0001299_abnormal_eye_distance/0.61224051
133MP0001915_intracranial_hemorrhage0.60949848
134MP0003950_abnormal_plasma_membrane0.59083432
135MP0001835_abnormal_antigen_presentation0.58931548
136MP0001529_abnormal_vocalization0.58506174
137* MP0001177_atelectasis0.57875676
138MP0002111_abnormal_tail_morphology0.57757729
139MP0005171_absent_coat_pigmentation0.54600808
140MP0000858_altered_metastatic_potential0.54358433

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.64451672
2Chromsome breakage (HP:0040012)4.09453656
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91738587
4Carpal bone hypoplasia (HP:0001498)3.69301036
5Degeneration of anterior horn cells (HP:0002398)3.69274502
6Abnormality of the anterior horn cell (HP:0006802)3.69274502
7Abnormality of glycolysis (HP:0004366)3.61256316
8Supernumerary spleens (HP:0009799)3.52275679
9Cortical dysplasia (HP:0002539)3.49554556
10Breast hypoplasia (HP:0003187)3.48680371
11Increased serum pyruvate (HP:0003542)3.42888770
12Increased nuchal translucency (HP:0010880)3.39445691
1311 pairs of ribs (HP:0000878)3.32622491
14True hermaphroditism (HP:0010459)3.17431455
15Syringomyelia (HP:0003396)3.02658344
16Spinal cord lesions (HP:0100561)3.02658344
17Volvulus (HP:0002580)3.01462040
18Pancreatic fibrosis (HP:0100732)3.00232457
19Patellar aplasia (HP:0006443)2.98917376
20Ectopic kidney (HP:0000086)2.93516425
21Abnormal lung lobation (HP:0002101)2.93180183
22Meckel diverticulum (HP:0002245)2.82890453
23Microvesicular hepatic steatosis (HP:0001414)2.79928547
24Rectal fistula (HP:0100590)2.78594856
25Rectovaginal fistula (HP:0000143)2.78594856
26Aplasia/Hypoplasia of the patella (HP:0006498)2.78008885
27Abnormality of chromosome stability (HP:0003220)2.74476536
28Impulsivity (HP:0100710)2.73649491
29Nephroblastoma (Wilms tumor) (HP:0002667)2.67629000
30Type I transferrin isoform profile (HP:0003642)2.66367305
31Shoulder girdle muscle weakness (HP:0003547)2.62616192
32Abnormality of the ileum (HP:0001549)2.61996626
33Aplastic anemia (HP:0001915)2.61863543
34Irregular epiphyses (HP:0010582)2.60633926
35Intestinal fistula (HP:0100819)2.59933350
36Embryonal renal neoplasm (HP:0011794)2.56880872
37Multiple enchondromatosis (HP:0005701)2.52653192
38Abnormality of the preputium (HP:0100587)2.52533278
39Pancreatic cysts (HP:0001737)2.50846698
40Stenosis of the external auditory canal (HP:0000402)2.49874068
41Cholecystitis (HP:0001082)2.48582210
42Abnormal gallbladder physiology (HP:0012438)2.48582210
43Medulloblastoma (HP:0002885)2.43952595
44Proximal placement of thumb (HP:0009623)2.42526330
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.39802562
46Abnormality of the labia minora (HP:0012880)2.39148803
47Absent thumb (HP:0009777)2.38568276
48Postnatal microcephaly (HP:0005484)2.36365719
49Optic nerve coloboma (HP:0000588)2.35633964
50Oral leukoplakia (HP:0002745)2.34227839
51Ependymoma (HP:0002888)2.28917111
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.28324881
53Absent radius (HP:0003974)2.25109931
54Preaxial hand polydactyly (HP:0001177)2.24029300
55Deviation of the thumb (HP:0009603)2.24007286
56Colon cancer (HP:0003003)2.23337189
57Rhabdomyosarcoma (HP:0002859)2.21428838
58Cutaneous melanoma (HP:0012056)2.18945448
59Bone marrow hypocellularity (HP:0005528)2.18215603
60Vaginal fistula (HP:0004320)2.15073906
61Abnormality of methionine metabolism (HP:0010901)2.14878781
62Adrenal hypoplasia (HP:0000835)2.13701748
63Myelodysplasia (HP:0002863)2.12943757
64Asymmetry of the thorax (HP:0001555)2.11807978
65Spastic diplegia (HP:0001264)2.10046510
66Neoplasm of the colon (HP:0100273)2.09416160
67Abnormal umbilical cord blood vessels (HP:0011403)2.06941781
68Single umbilical artery (HP:0001195)2.06941781
69Abnormality of the fetal cardiovascular system (HP:0010948)2.06941781
70Sloping forehead (HP:0000340)2.05126503
71Aplasia involving forearm bones (HP:0009822)2.05016803
72Absent forearm bone (HP:0003953)2.05016803
73Small intestinal stenosis (HP:0012848)2.04554946
74Duodenal stenosis (HP:0100867)2.04554946
75Thyroid carcinoma (HP:0002890)2.03788496
76Gonadotropin excess (HP:0000837)2.03493881
77Progressive external ophthalmoplegia (HP:0000590)2.00846437
78Abnormality of incisor morphology (HP:0011063)1.99615303
79Horseshoe kidney (HP:0000085)1.98473830
80Gout (HP:0001997)1.98350103
81Embryonal neoplasm (HP:0002898)1.97049475
82Abnormal spermatogenesis (HP:0008669)1.96697353
83Pelvic girdle muscle weakness (HP:0003749)1.96693866
84Postaxial foot polydactyly (HP:0001830)1.95644700
85Acute myeloid leukemia (HP:0004808)1.95446645
86Abnormality of the umbilical cord (HP:0010881)1.95413870
87Long clavicles (HP:0000890)1.94751875
88Insidious onset (HP:0003587)1.93803491
89Termporal pattern (HP:0011008)1.93803491
90Abnormality of the musculature of the pelvis (HP:0001469)1.93424199
91Abnormality of the hip-girdle musculature (HP:0001445)1.93424199
92Clubbing of toes (HP:0100760)1.92692336
93Choanal atresia (HP:0000453)1.92010194
94Papillary thyroid carcinoma (HP:0002895)1.91622554
95Rough bone trabeculation (HP:0100670)1.86869473
96Selective tooth agenesis (HP:0001592)1.86750300
97Alveolar cell carcinoma (HP:0006519)1.86509593
98Megaloblastic anemia (HP:0001889)1.86030208
99Occipital encephalocele (HP:0002085)1.85759742
100Cafe-au-lait spot (HP:0000957)1.85755904
101Chronic bronchitis (HP:0004469)1.85682242
102Premature graying of hair (HP:0002216)1.85511603
103Microglossia (HP:0000171)1.85033428
104Diastasis recti (HP:0001540)1.84797632
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83410600
106Glioma (HP:0009733)1.83306782
107Overlapping toe (HP:0001845)1.82217633
108Hyperglycinemia (HP:0002154)1.80973211
109Deep philtrum (HP:0002002)1.80600610
110Tongue fasciculations (HP:0001308)1.80237718
111Ovarian neoplasm (HP:0100615)1.79259448
112Breast carcinoma (HP:0003002)1.78466396
113Atrophy/Degeneration involving motor neurons (HP:0007373)1.77951008
114Missing ribs (HP:0000921)1.77764310
115Abnormality of the renal collecting system (HP:0004742)1.75807724
116Facial cleft (HP:0002006)1.75351451
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75229708
118Cystic hygroma (HP:0000476)1.75065998
119Abnormality of serum amino acid levels (HP:0003112)1.73364251
120Abnormality of the carotid arteries (HP:0005344)1.73286877
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72646753
122Duplicated collecting system (HP:0000081)1.72012855
123Triphalangeal thumb (HP:0001199)1.71284865
124Poor coordination (HP:0002370)1.71197715
125Abnormal hair whorl (HP:0010721)1.71034140
126Exercise-induced muscle cramps (HP:0003710)1.70934932
127Rhinitis (HP:0012384)1.70531274
128Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70438731
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.69172657
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.68670666
131Median cleft lip (HP:0000161)1.67881118
132Abnormalities of placenta or umbilical cord (HP:0001194)1.66265843
133Secondary amenorrhea (HP:0000869)1.65772656
134Cerebral hypomyelination (HP:0006808)1.65588763
135Abnormal respiratory motile cilium physiology (HP:0012261)1.65191544
136Neoplasm of the adrenal gland (HP:0100631)1.64694766
137Absent epiphyses (HP:0010577)1.64548681
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64548681
139Neoplasm of the small intestine (HP:0100833)1.64546935
140Medial flaring of the eyebrow (HP:0010747)1.64445208
141Uterine neoplasm (HP:0010784)1.64122835
142Abnormality of the duodenum (HP:0002246)1.63222320
143Short thumb (HP:0009778)1.62689209
144Capillary hemangiomas (HP:0005306)1.62539343
145Abnormal respiratory motile cilium morphology (HP:0005938)1.62357690
146Abnormal respiratory epithelium morphology (HP:0012253)1.62357690
147Abnormal trabecular bone morphology (HP:0100671)1.62137592
148Abnormality of serine family amino acid metabolism (HP:0010894)1.62073915
149Abnormality of glycine metabolism (HP:0010895)1.62073915
150Prominent metopic ridge (HP:0005487)1.61567241
151Astrocytoma (HP:0009592)1.61324819
152Abnormality of the astrocytes (HP:0100707)1.61324819
153Type 2 muscle fiber atrophy (HP:0003554)1.61107776
154Tubulointerstitial nephritis (HP:0001970)1.60290411
155Metaphyseal dysplasia (HP:0100255)1.60032985
156Malignant gastrointestinal tract tumors (HP:0006749)1.59221262
157Gastrointestinal carcinoma (HP:0002672)1.59221262
158Neoplasm of the adrenal cortex (HP:0100641)1.59213208
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.58661198
160Neuroblastoma (HP:0003006)1.55380439
161Primitive neuroectodermal tumor (HP:0030065)1.55380439
162Neuroblastic tumors (HP:0004376)1.55380439
163Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.55380439
164Abnormality of chromosome segregation (HP:0002916)1.54566112
165Progressive muscle weakness (HP:0003323)1.53650917
166Biliary tract neoplasm (HP:0100574)1.53519164
167Reduced antithrombin III activity (HP:0001976)1.51802133
168Increased hepatocellular lipid droplets (HP:0006565)1.51765779
169Hypoplastic pelvis (HP:0008839)1.51261299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.56226175
2BRSK23.54025499
3TRIM283.33194490
4SRPK13.21985080
5WEE13.00348180
6MKNK12.91370092
7PLK42.84446963
8CDC72.82811491
9ZAK2.69174719
10MKNK22.51784895
11SIK32.39552347
12PLK32.34332510
13STK38L2.30966567
14BUB12.20382663
15EIF2AK32.10741077
16VRK12.09404875
17BRSK12.06240884
18AKT32.03297998
19MAP3K141.96992345
20ERBB31.95035093
21PNCK1.88370631
22STK241.83531064
23NEK61.73511087
24TSSK61.70042500
25NEK91.61876305
26PLK21.56392970
27BCR1.55015920
28VRK21.54825530
29SCYL21.54081516
30PLK11.51079403
31ACVR1B1.50367726
32EIF2AK21.50158237
33CCNB11.46912228
34STK161.43640150
35CDK81.40820049
36NEK11.35749666
37BMPR21.33333441
38MST41.26089009
39FRK1.21750860
40PASK1.20399012
41CLK11.17172428
42IRAK31.14567841
43TTK1.12517754
44PBK1.11275496
45TAF11.11170968
46ATR1.09418580
47PAK41.09058733
48CDK61.08286862
49IRAK41.07991924
50SGK21.07530762
51YES11.02722874
52CHEK20.99355572
53NUAK10.97404058
54AURKB0.96806996
55DYRK30.91675794
56LATS20.90951169
57STK40.90883773
58KSR10.89354077
59TRPM70.84620932
60ALK0.83535874
61NEK20.82895997
62CDK70.81101563
63AURKA0.81099676
64BRAF0.80412242
65BMPR1B0.79982901
66MST1R0.77706874
67CASK0.76440156
68CSNK1G30.74701547
69PIM20.74220032
70CDK180.73951761
71CDK190.73562117
72TESK10.73476864
73SMG10.73376246
74CDK140.73233814
75MAP3K100.73087944
76LATS10.72981163
77BRD40.72190234
78PIM10.71613284
79PRPF4B0.70254758
80ERBB40.69912264
81MAP3K120.69788918
82ATM0.69113030
83CSNK1G20.68983613
84STK30.68572498
85CHEK10.67354008
86CSNK1G10.67284452
87LIMK10.67083167
88MINK10.66617000
89OBSCN0.65589873
90ARAF0.65302215
91MET0.64328837
92* CSNK2A10.63656849
93CSNK1A1L0.63508825
94MARK30.63116977
95PINK10.61126298
96CDK11A0.60608574
97CDK150.60603394
98TEC0.60554560
99TGFBR10.59992421
100TXK0.58805531
101MAP3K30.56441987
102MYLK0.55505834
103CHUK0.53844292
104FGFR10.53745236
105CSNK1E0.53018579
106JAK30.52711166
107RPS6KB10.51255090
108CDK120.50082269
109MELK0.49087082
110CDK20.48640811
111WNK30.48289723
112RPS6KA60.47799293
113RPS6KC10.46512908
114RPS6KL10.46512908
115CDK90.46509206
116STK100.45500975
117RPS6KA40.45207890
118RAF10.43617926
119EPHA20.43555576
120UHMK10.43133916
121CSNK2A20.42701061
122NME20.41155909
123CDK10.41044117
124RPS6KB20.39639793
125SGK30.39614782
126DAPK10.38066264
127SGK4940.36265079
128SGK2230.36265079
129MAP3K90.36121611
130TNIK0.35065107
131AKT20.34140441
132IKBKB0.33815512
133ADRBK20.30745068
134ABL20.26525885
135MAPKAPK20.24303121
136CDK30.23925718
137CDK40.23538516
138MAP3K80.23280759
139PRKCI0.21971642
140NME10.21729175

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.56678328
2Mismatch repair_Homo sapiens_hsa034304.20460226
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.74253209
4Proteasome_Homo sapiens_hsa030503.59448777
5RNA polymerase_Homo sapiens_hsa030203.45094782
6Homologous recombination_Homo sapiens_hsa034403.30105633
7Base excision repair_Homo sapiens_hsa034103.13877529
8Nucleotide excision repair_Homo sapiens_hsa034202.95867615
9Cell cycle_Homo sapiens_hsa041102.90671155
10RNA transport_Homo sapiens_hsa030132.73797019
11Basal transcription factors_Homo sapiens_hsa030222.73372951
12Spliceosome_Homo sapiens_hsa030402.67497234
13Pyrimidine metabolism_Homo sapiens_hsa002402.62453979
14One carbon pool by folate_Homo sapiens_hsa006702.40466272
15Fanconi anemia pathway_Homo sapiens_hsa034602.37932573
16RNA degradation_Homo sapiens_hsa030182.32675676
17Non-homologous end-joining_Homo sapiens_hsa034502.08889513
18Protein export_Homo sapiens_hsa030601.96547968
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93528892
20Steroid biosynthesis_Homo sapiens_hsa001001.83629408
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74617234
22Pyruvate metabolism_Homo sapiens_hsa006201.67036682
23Purine metabolism_Homo sapiens_hsa002301.66045996
24Carbon metabolism_Homo sapiens_hsa012001.64033110
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61140748
26Ribosome_Homo sapiens_hsa030101.60803363
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58725672
28mRNA surveillance pathway_Homo sapiens_hsa030151.58167056
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52395047
30p53 signaling pathway_Homo sapiens_hsa041151.46727520
31Propanoate metabolism_Homo sapiens_hsa006401.42857879
32Fatty acid elongation_Homo sapiens_hsa000621.30034944
33Epstein-Barr virus infection_Homo sapiens_hsa051691.29556381
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25418901
35Huntingtons disease_Homo sapiens_hsa050161.21958405
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21286947
37Folate biosynthesis_Homo sapiens_hsa007901.14036717
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98086812
39Herpes simplex infection_Homo sapiens_hsa051680.95789204
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93208270
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92484673
42Thyroid cancer_Homo sapiens_hsa052160.92358995
43Legionellosis_Homo sapiens_hsa051340.88728106
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87502059
45Parkinsons disease_Homo sapiens_hsa050120.87351308
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83009457
47Oocyte meiosis_Homo sapiens_hsa041140.82559633
48Glutathione metabolism_Homo sapiens_hsa004800.81574847
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.81529782
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80108434
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77892773
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73078904
53Antigen processing and presentation_Homo sapiens_hsa046120.71950085
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71377575
55Viral carcinogenesis_Homo sapiens_hsa052030.71249450
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68584926
57Oxidative phosphorylation_Homo sapiens_hsa001900.68083598
58Allograft rejection_Homo sapiens_hsa053300.67725627
59Vitamin B6 metabolism_Homo sapiens_hsa007500.66156091
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.65990125
61Arginine and proline metabolism_Homo sapiens_hsa003300.63220256
62TGF-beta signaling pathway_Homo sapiens_hsa043500.63191819
63Autoimmune thyroid disease_Homo sapiens_hsa053200.58529454
64Fatty acid metabolism_Homo sapiens_hsa012120.56260317
65Measles_Homo sapiens_hsa051620.55623596
66Influenza A_Homo sapiens_hsa051640.55066379
67HTLV-I infection_Homo sapiens_hsa051660.54988124
68Graft-versus-host disease_Homo sapiens_hsa053320.54627348
69Sulfur relay system_Homo sapiens_hsa041220.54051588
70Systemic lupus erythematosus_Homo sapiens_hsa053220.52290554
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51985082
72* Arachidonic acid metabolism_Homo sapiens_hsa005900.50920606
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50458171
74Selenocompound metabolism_Homo sapiens_hsa004500.49067755
75MicroRNAs in cancer_Homo sapiens_hsa052060.46296661
76Type I diabetes mellitus_Homo sapiens_hsa049400.43701788
77Galactose metabolism_Homo sapiens_hsa000520.43248301
78Hepatitis B_Homo sapiens_hsa051610.41811909
79N-Glycan biosynthesis_Homo sapiens_hsa005100.40491538
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37542157
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37395683
82Hippo signaling pathway_Homo sapiens_hsa043900.37192076
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.36805597
84Colorectal cancer_Homo sapiens_hsa052100.36339877
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.34926334
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34207798
87Wnt signaling pathway_Homo sapiens_hsa043100.31947615
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31385205
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30607249
90beta-Alanine metabolism_Homo sapiens_hsa004100.30575138
91Asthma_Homo sapiens_hsa053100.30466651
92Lysine degradation_Homo sapiens_hsa003100.29893204
93Fructose and mannose metabolism_Homo sapiens_hsa000510.29651121
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29411645
95Vibrio cholerae infection_Homo sapiens_hsa051100.29405108
96Prostate cancer_Homo sapiens_hsa052150.28930672
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.28893592
98Melanoma_Homo sapiens_hsa052180.28750092
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28508239
100* Metabolic pathways_Homo sapiens_hsa011000.28319534
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26344812
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26148018
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25476873
104Apoptosis_Homo sapiens_hsa042100.24040355
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.23575749
106Tight junction_Homo sapiens_hsa045300.22993388
107Bladder cancer_Homo sapiens_hsa052190.22300487
108Arginine biosynthesis_Homo sapiens_hsa002200.21730070
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21628744
110Alzheimers disease_Homo sapiens_hsa050100.20642860
111Phenylalanine metabolism_Homo sapiens_hsa003600.20186403
112Adherens junction_Homo sapiens_hsa045200.19918110
113Small cell lung cancer_Homo sapiens_hsa052220.19258115
114Phagosome_Homo sapiens_hsa041450.18790842
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18209106
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18096809
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17135447
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16599546
119Shigellosis_Homo sapiens_hsa051310.14578458
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14400267
121FoxO signaling pathway_Homo sapiens_hsa040680.14171711
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13609957
123Pathways in cancer_Homo sapiens_hsa052000.13371206
124Biosynthesis of amino acids_Homo sapiens_hsa012300.10778058
125Fatty acid degradation_Homo sapiens_hsa000710.10502648
126Peroxisome_Homo sapiens_hsa041460.09334120
127HIF-1 signaling pathway_Homo sapiens_hsa040660.09056899
128Hematopoietic cell lineage_Homo sapiens_hsa046400.08632599
129Basal cell carcinoma_Homo sapiens_hsa052170.08159076
130Pentose phosphate pathway_Homo sapiens_hsa000300.08101698
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08035701
132Hedgehog signaling pathway_Homo sapiens_hsa043400.06379977
133Pancreatic cancer_Homo sapiens_hsa052120.05478627

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