PTGES3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.23085479
2positive regulation of gamma-delta T cell activation (GO:0046645)5.09999413
3negative regulation of cell killing (GO:0031342)4.99570501
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.99570501
5response to peptidoglycan (GO:0032494)4.67110221
6cellular response to type I interferon (GO:0071357)4.30316980
7type I interferon signaling pathway (GO:0060337)4.30316980
8macrophage activation involved in immune response (GO:0002281)4.26166840
9response to type I interferon (GO:0034340)4.24524114
10modulation by symbiont of host immune response (GO:0052553)4.07534010
11positive regulation by symbiont of host defense response (GO:0052509)4.07534010
12modulation by symbiont of host defense response (GO:0052031)4.07534010
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07534010
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07534010
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.07534010
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.04901548
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04470928
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.02379219
19lipopolysaccharide-mediated signaling pathway (GO:0031663)3.97558799
20regulation of T-helper 1 cell differentiation (GO:0045625)3.96566462
21neutrophil activation involved in immune response (GO:0002283)3.92094909
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.87193234
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.83023555
24regulation of interferon-alpha production (GO:0032647)3.82956317
25immunoglobulin mediated immune response (GO:0016064)3.82822614
26defense response to protozoan (GO:0042832)3.82401991
27regulation of vitamin D biosynthetic process (GO:0060556)3.80718439
28leukocyte aggregation (GO:0070486)3.77225750
29regulation of gamma-delta T cell activation (GO:0046643)3.77203854
30regulation of interferon-beta biosynthetic process (GO:0045357)3.76907176
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.74926940
32regulation of chronic inflammatory response (GO:0002676)3.71721350
33antigen processing and presentation of endogenous antigen (GO:0019883)3.71452591
34response to protozoan (GO:0001562)3.63208912
35regulation of regulatory T cell differentiation (GO:0045589)3.62908941
36detection of other organism (GO:0098543)3.60206752
37regulation of T cell tolerance induction (GO:0002664)3.60176140
38detection of molecule of bacterial origin (GO:0032490)3.58693670
39negative regulation of cytokine production involved in immune response (GO:0002719)3.53053825
40germinal center formation (GO:0002467)3.52680852
41interferon-gamma-mediated signaling pathway (GO:0060333)3.52067853
42granulocyte activation (GO:0036230)3.51202039
43positive regulation of interferon-alpha production (GO:0032727)3.46007561
44response to muramyl dipeptide (GO:0032495)3.44730100
45negative regulation of T cell mediated immunity (GO:0002710)3.44345696
46T-helper 1 type immune response (GO:0042088)3.40757062
47NIK/NF-kappaB signaling (GO:0038061)3.40123498
48T cell migration (GO:0072678)3.36774889
49neutrophil activation (GO:0042119)3.32743081
50positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.29816442
51regulation of fever generation (GO:0031620)3.29107832
52regulation of tolerance induction (GO:0002643)3.26017844
53positive regulation of type 2 immune response (GO:0002830)3.24828781
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24828370
55detection of bacterium (GO:0016045)3.24454464
56response to interleukin-15 (GO:0070672)3.23438634
57regulation of B cell receptor signaling pathway (GO:0050855)3.22960875
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.21539936
59regulation of interleukin-12 production (GO:0032655)3.19924902
60myeloid dendritic cell differentiation (GO:0043011)3.19063628
61negative regulation of viral genome replication (GO:0045071)3.18435680
62detection of external biotic stimulus (GO:0098581)3.16036561
63macrophage activation (GO:0042116)3.15648739
64positive regulation of NF-kappaB import into nucleus (GO:0042346)3.14454381
65positive regulation of tolerance induction (GO:0002645)3.13466350
66regulation of cytokine secretion involved in immune response (GO:0002739)3.12286996
67positive regulation of heat generation (GO:0031652)3.12198862
68cellular response to interleukin-15 (GO:0071350)3.09424164
69regulation of podosome assembly (GO:0071801)3.09384015
70regulation of T-helper 2 cell differentiation (GO:0045628)3.09333443
71tolerance induction (GO:0002507)3.07574354
72positive regulation of interleukin-1 beta secretion (GO:0050718)3.06536397
73myeloid cell activation involved in immune response (GO:0002275)3.06283998
74microglial cell activation (GO:0001774)3.04401449
75interferon-gamma secretion (GO:0072643)3.03559138
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03354944
77cellular extravasation (GO:0045123)3.02089052
78positive regulation of chemokine biosynthetic process (GO:0045080)3.01155330
79regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.00361641
80regulation of gamma-delta T cell differentiation (GO:0045586)2.99162148
81regulation of interleukin-1 beta secretion (GO:0050706)2.97246817
82B cell mediated immunity (GO:0019724)2.97246078
83regulation of T-helper cell differentiation (GO:0045622)2.97214986
84positive regulation of acute inflammatory response (GO:0002675)2.95201831
85regulation of interleukin-8 biosynthetic process (GO:0045414)2.94314079
86regulation of alpha-beta T cell proliferation (GO:0046640)2.94274826
87regulation of vitamin metabolic process (GO:0030656)2.94042429
88positive regulation of interleukin-17 production (GO:0032740)2.93555302
89positive regulation of defense response to virus by host (GO:0002230)2.93542542
90regulation of interleukin-2 biosynthetic process (GO:0045076)2.92180930
91detection of biotic stimulus (GO:0009595)2.91528051
92myeloid dendritic cell activation (GO:0001773)2.91288528
93negative regulation of interleukin-6 production (GO:0032715)2.88150364
94JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88057998
95lymphocyte chemotaxis (GO:0048247)2.87928426
96positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.87701134
97regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.87423826
98production of molecular mediator involved in inflammatory response (GO:0002532)2.87070310
99regulation of interleukin-12 biosynthetic process (GO:0045075)2.86986480
100positive regulation of interleukin-1 secretion (GO:0050716)2.86932277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.82711632
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.46317912
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.14719844
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.50830329
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.46772708
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.33703354
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.67663421
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.59805370
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20908698
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.20712435
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.12958374
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00377353
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.88586801
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80492764
15RUNX_20019798_ChIP-Seq_JUKART_Human2.62291509
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50119389
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.46968099
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40602722
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.36646366
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29061446
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16306518
22MYB_26560356_Chip-Seq_TH2_Human2.14172516
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.13056025
24SPI1_23547873_ChIP-Seq_NB4_Human2.12230795
25VDR_24763502_ChIP-Seq_THP-1_Human2.06170991
26MAF_26560356_Chip-Seq_TH1_Human2.02945983
27SPI1_23127762_ChIP-Seq_K562_Human2.02734913
28VDR_24787735_ChIP-Seq_THP-1_Human2.00929213
29GATA1_22025678_ChIP-Seq_K562_Human2.00320498
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97740566
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97300347
32VDR_21846776_ChIP-Seq_THP-1_Human1.77376090
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75794568
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73803884
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72700889
36SCL_19346495_ChIP-Seq_HPC-7_Human1.70185481
37MYB_26560356_Chip-Seq_TH1_Human1.68091203
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61964677
39UTX_26944678_Chip-Seq_JUKART_Human1.61515023
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.60470880
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51116439
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49892106
43GATA3_27048872_Chip-Seq_THYMUS_Human1.49784192
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45774753
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45733836
46MAF_26560356_Chip-Seq_TH2_Human1.45200833
47GATA3_26560356_Chip-Seq_TH2_Human1.42953247
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38643034
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38534797
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36791989
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36113007
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35960057
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33133515
54PU_27001747_Chip-Seq_BMDM_Mouse1.29411775
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24925608
56SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24003222
57KDM2B_26808549_Chip-Seq_DND41_Human1.20750130
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16446921
59TCF7_22412390_ChIP-Seq_EML_Mouse1.16203354
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15978689
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14736289
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14376213
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12983928
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07072982
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.06795697
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05598315
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04303589
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02768006
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99967780
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99910470
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99009427
72MYC_22102868_ChIP-Seq_BL_Human0.97539595
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97154961
74NOTCH1_21737748_ChIP-Seq_TLL_Human0.95900321
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95258116
76EGR1_19032775_ChIP-ChIP_M12_Human0.94951797
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91359301
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88243773
79KDM2B_26808549_Chip-Seq_JURKAT_Human0.88102185
80STAT1_20625510_ChIP-Seq_HELA_Human0.85736211
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85392963
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85165958
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82094464
84GATA1_19941826_ChIP-Seq_K562_Human0.79125621
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78778275
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76801236
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.74863150
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74521043
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74521043
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74521043
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.71324467
92SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.69331517
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69253166
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.68782834
95BCL6_27268052_Chip-Seq_Bcells_Human0.68207781
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.67675583
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66783478
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.62555656
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.61591033
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.60636264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.65680385
2MP0003724_increased_susceptibility_to4.93601386
3MP0003436_decreased_susceptibility_to3.99110040
4MP0001835_abnormal_antigen_presentation3.79748269
5MP0009785_altered_susceptibility_to3.51663514
6MP0006082_CNS_inflammation3.44054730
7MP0005671_abnormal_response_to3.43269177
8MP0002148_abnormal_hypersensitivity_rea3.23800140
9MP0005000_abnormal_immune_tolerance3.05573391
10MP0001790_abnormal_immune_system2.91055666
11MP0005387_immune_system_phenotype2.91055666
12MP0005025_abnormal_response_to2.86862865
13MP0002419_abnormal_innate_immunity2.80814051
14MP0001800_abnormal_humoral_immune2.77319339
15MP0004510_myositis2.66653695
16MP0003300_gastrointestinal_ulcer2.66287222
17MP0002723_abnormal_immune_serum2.62373085
18MP0002452_abnormal_antigen_presenting2.46948497
19MP0009764_decreased_sensitivity_to2.33712547
20MP0002420_abnormal_adaptive_immunity2.25746598
21MP0001819_abnormal_immune_cell2.24991383
22MP0000685_abnormal_immune_system2.24356208
23MP0001533_abnormal_skeleton_physiology2.22918417
24MP0004947_skin_inflammation2.09831042
25MP0001853_heart_inflammation2.03434842
26MP0010155_abnormal_intestine_physiology1.97478502
27MP0002405_respiratory_system_inflammati1.86857995
28MP0003075_altered_response_to1.85452785
29MP0003763_abnormal_thymus_physiology1.84992438
30MP0001845_abnormal_inflammatory_respons1.82224433
31MP0008004_abnormal_stomach_pH1.77812036
32MP0009278_abnormal_bone_marrow1.74218574
33MP0008469_abnormal_protein_level1.69265657
34MP0000716_abnormal_immune_system1.65763031
35MP0009333_abnormal_splenocyte_physiolog1.60670808
36MP0002398_abnormal_bone_marrow1.54211660
37MP0000465_gastrointestinal_hemorrhage1.47027535
38MP0002332_abnormal_exercise_endurance1.45838223
39MP0003448_altered_tumor_morphology1.42015721
40MP0002277_abnormal_respiratory_mucosa1.40652606
41MP0005058_abnormal_lysosome_morphology1.32831161
42MP0000343_altered_response_to1.30695008
43MP0005310_abnormal_salivary_gland1.27245167
44MP0005167_abnormal_blood-brain_barrier1.25355753
45MP0005166_decreased_susceptibility_to1.24579317
46MP0002429_abnormal_blood_cell1.22601605
47MP0000689_abnormal_spleen_morphology1.22000870
48MP0002998_abnormal_bone_remodeling1.21615398
49MP0000858_altered_metastatic_potential1.21263331
50MP0005464_abnormal_platelet_physiology1.21198033
51MP0003191_abnormal_cellular_cholesterol1.20051848
52MP0002722_abnormal_immune_system1.19403595
53MP0005397_hematopoietic_system_phenotyp1.16605556
54MP0001545_abnormal_hematopoietic_system1.16605556
55MP0005164_abnormal_response_to1.13968847
56MP0003453_abnormal_keratinocyte_physiol1.13854921
57MP0003172_abnormal_lysosome_physiology1.09225633
58MP0002138_abnormal_hepatobiliary_system1.08365999
59MP0000604_amyloidosis1.08136561
60MP0005451_abnormal_body_composition1.07467937
61MP0000569_abnormal_digit_pigmentation1.06882300
62MP0003866_abnormal_defecation1.06672942
63MP0004883_abnormal_blood_vessel1.01871336
64MP0001663_abnormal_digestive_system0.99376752
65MP0003806_abnormal_nucleotide_metabolis0.99220901
66MP0003195_calcinosis0.99087543
67MP0009763_increased_sensitivity_to0.98790660
68MP0003045_fibrosis0.97961898
69MP0008260_abnormal_autophagy0.96146284
70MP0000703_abnormal_thymus_morphology0.94353413
71MP0003690_abnormal_glial_cell0.93310176
72MP0003183_abnormal_peptide_metabolism0.92427863
73MP0009765_abnormal_xenobiotic_induced0.92078310
74MP0003828_pulmonary_edema0.91031728
75MP0005390_skeleton_phenotype0.90388781
76MP0002139_abnormal_hepatobiliary_system0.88971301
77MP0005535_abnormal_body_temperature0.86887935
78MP0001873_stomach_inflammation0.86762370
79MP0003646_muscle_fatigue0.81500900
80MP0006054_spinal_hemorrhage0.81079972
81MP0003091_abnormal_cell_migration0.80101544
82MP0002132_abnormal_respiratory_system0.77715493
83MP0009840_abnormal_foam_cell0.76328372
84MP0001501_abnormal_sleep_pattern0.74090776
85MP0003656_abnormal_erythrocyte_physiolo0.71070842
86MP0002933_joint_inflammation0.67632024
87MP0001851_eye_inflammation0.67563156
88MP0002254_reproductive_system_inflammat0.67544432
89MP0004381_abnormal_hair_follicle0.65996928
90MP0004808_abnormal_hematopoietic_stem0.64426135
91MP0000249_abnormal_blood_vessel0.60359195
92MP0005381_digestive/alimentary_phenotyp0.58839763
93MP0008874_decreased_physiological_sensi0.58549096
94MP0000490_abnormal_crypts_of0.55922706
95MP0002693_abnormal_pancreas_physiology0.55325190
96MP0002006_tumorigenesis0.52877600
97MP0003795_abnormal_bone_structure0.52247501
98MP0005266_abnormal_metabolism0.50655921
99MP0000920_abnormal_myelination0.50092307
100MP0003221_abnormal_cardiomyocyte_apopto0.49412117

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)6.71351701
2Retrobulbar optic neuritis (HP:0100654)6.71351701
3Orchitis (HP:0100796)6.47710861
4Myositis (HP:0100614)6.11739018
5Stomatitis (HP:0010280)5.96272162
6Eczematoid dermatitis (HP:0000976)5.64892341
7Recurrent bacterial skin infections (HP:0005406)5.20831123
8Elevated erythrocyte sedimentation rate (HP:0003565)5.18595113
9Recurrent abscess formation (HP:0002722)4.82261087
10Keratoconjunctivitis sicca (HP:0001097)4.70256972
11Abnormality of macrophages (HP:0004311)4.69019200
12Keratoconjunctivitis (HP:0001096)4.28319659
13Vasculitis (HP:0002633)4.08482657
14Mediastinal lymphadenopathy (HP:0100721)4.05979981
15Gastrointestinal infarctions (HP:0005244)3.81030911
16Abnormality of glycolipid metabolism (HP:0010969)3.80394737
17Abnormality of liposaccharide metabolism (HP:0010968)3.80394737
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.80394737
19Recurrent gram-negative bacterial infections (HP:0005420)3.80285567
20T lymphocytopenia (HP:0005403)3.77764962
21Abnormality of T cell number (HP:0011839)3.64645497
22Increased IgM level (HP:0003496)3.64521744
23Pulmonary infiltrates (HP:0002113)3.64491225
24Recurrent fungal infections (HP:0002841)3.61432490
25Gangrene (HP:0100758)3.61355845
26Encephalitis (HP:0002383)3.61173705
27Hemoptysis (HP:0002105)3.45233773
28Meningitis (HP:0001287)3.44871116
29Recurrent skin infections (HP:0001581)3.37715430
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.35089216
31Chronic obstructive pulmonary disease (HP:0006510)3.22717770
32Obstructive lung disease (HP:0006536)3.22717770
33Autoimmune thrombocytopenia (HP:0001973)3.21476280
34Arterial thrombosis (HP:0004420)3.08669826
35Leukocytosis (HP:0001974)3.00442361
36Autoimmune hemolytic anemia (HP:0001890)2.99178676
37Systemic lupus erythematosus (HP:0002725)2.91738687
38Chronic mucocutaneous candidiasis (HP:0002728)2.91644025
39Recurrent cutaneous fungal infections (HP:0011370)2.91644025
40Increased IgE level (HP:0003212)2.90864497
41Anorexia (HP:0002039)2.87161494
42Pulmonary embolism (HP:0002204)2.86679908
43Abnormality of the pleura (HP:0002103)2.83224185
44Recurrent viral infections (HP:0004429)2.81735154
45Chest pain (HP:0100749)2.76959710
46Episodic fever (HP:0001954)2.73076951
47Abnormality of T cells (HP:0002843)2.70538470
48Urticaria (HP:0001025)2.69456143
49Stomach cancer (HP:0012126)2.67249161
50Disinhibition (HP:0000734)2.67192433
51Gingivitis (HP:0000230)2.65322946
52Spontaneous hematomas (HP:0007420)2.50258330
53Polyneuropathy (HP:0001271)2.49987331
54Hypergammaglobulinemia (HP:0010702)2.48799521
55Recurrent bronchitis (HP:0002837)2.44249962
56Alveolar cell carcinoma (HP:0006519)2.43825369
57Abnormality of the pericardium (HP:0001697)2.41585191
58Parakeratosis (HP:0001036)2.40931122
59Amyloidosis (HP:0011034)2.36676145
60Eosinophilia (HP:0001880)2.35837222
61Neoplasm of the tracheobronchial system (HP:0100552)2.32750606
62Peritonitis (HP:0002586)2.32120734
63Loss of speech (HP:0002371)2.30497736
64Chronic otitis media (HP:0000389)2.28141232
65Glomerulopathy (HP:0100820)2.26893826
66Vertigo (HP:0002321)2.26502549
67Keratitis (HP:0000491)2.26384658
68Purpura (HP:0000979)2.25029537
69Dysostosis multiplex (HP:0000943)2.24491075
70Acne (HP:0001061)2.24073225
71Joint swelling (HP:0001386)2.23314725
72Granulocytopenia (HP:0001913)2.21729998
73Increased serum ferritin (HP:0003281)2.19856382
74Petechiae (HP:0000967)2.19762430
75Hepatosplenomegaly (HP:0001433)2.15771299
76Abnormality of eosinophils (HP:0001879)2.14815520
77Vacuolated lymphocytes (HP:0001922)2.13291577
78IgG deficiency (HP:0004315)2.11819008
79Lymphopenia (HP:0001888)2.10325990
80Interstitial pulmonary disease (HP:0006530)2.08773908
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08247852
82Abnormality of the endocardium (HP:0004306)2.04458502
83Gastrointestinal stroma tumor (HP:0100723)2.04157019
84Inflammation of the large intestine (HP:0002037)2.03390957
85Abnormality of B cell number (HP:0010975)2.01914057
86Panhypogammaglobulinemia (HP:0003139)2.01626104
87Arthralgia (HP:0002829)2.00470482
88Gingival bleeding (HP:0000225)1.99190686
89Severe combined immunodeficiency (HP:0004430)1.98882153
90Increased cerebral lipofuscin (HP:0011813)1.98488313
91Abnormality of cells of the lymphoid lineage (HP:0012140)1.98350205
92Colitis (HP:0002583)1.95361571
93Abnormality of T cell physiology (HP:0011840)1.94878151
94Prolonged bleeding time (HP:0003010)1.94649672
95Abnormality of iron homeostasis (HP:0011031)1.93319554
96Pustule (HP:0200039)1.90889333
97Epistaxis (HP:0000421)1.89662420
98Basal ganglia calcification (HP:0002135)1.88946196
99Abnormality of the peritoneum (HP:0002585)1.88771754
100Thrombophlebitis (HP:0004418)1.88704456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK43.92622387
2TXK3.83204464
3RIPK43.76740853
4MAP4K13.35902888
5MAP3K142.78136616
6IRAK32.74808745
7TYK22.67658943
8IKBKE2.61508672
9CSK2.52480543
10TBK12.38811313
11GRK72.33106789
12BLK2.31172079
13MAP2K32.24879461
14JAK32.10077654
15SIK32.09816381
16TAOK12.03628768
17IKBKB1.90467055
18MATK1.89577718
19IRAK11.88362828
20ZAP701.88340885
21BMPR21.87258656
22FGR1.84215056
23TAOK21.83944841
24MAP3K31.76867233
25MAP3K111.76425515
26RIPK11.69375503
27ERN11.63378257
28PRPF4B1.56463623
29SIK21.54536790
30JAK11.50511694
31TAOK31.49830154
32FES1.45395570
33IRAK21.42226712
34SYK1.41288927
35EPHB11.40204049
36TYRO31.29647023
37LYN1.27593378
38JAK21.27078331
39SIK11.24015552
40HCK1.22982293
41MARK31.22840828
42TNK21.16941011
43LCK1.13265536
44BTK1.13146017
45DDR21.12655116
46CHUK1.11869925
47EPHA31.11601344
48FGFR41.08815802
49TESK21.07744161
50MAP3K131.06847002
51MAP3K11.05716408
52ITK1.03873318
53CSF1R1.00122402
54MOS0.95397473
55TGFBR20.91816997
56GRK60.88758452
57KIT0.85445001
58MAP3K50.84095589
59MAP2K60.80945440
60CDC42BPA0.79735294
61ADRBK20.77963126
62DYRK1B0.74964615
63NME20.72924705
64FGFR30.71091836
65YES10.69342856
66PIM20.67842781
67PIM10.66128988
68DYRK30.66027632
69STK100.64708439
70TEC0.58921491
71MARK20.55816261
72HIPK20.52292896
73FYN0.50464851
74MAPK150.48710921
75PDK10.47491910
76NLK0.46664618
77CAMKK20.45268455
78PRKCQ0.43983330
79ACVR1B0.39718358
80MAPK40.29642870
81INSR0.29216873
82MAPKAPK20.23821474
83PDPK10.23692924
84KSR20.21519660
85CLK10.20848111
86LRRK20.19857198
87CAMKK10.18891439
88KSR10.17318293
89PRKCD0.17160417
90PDGFRB0.16897036
91PASK0.16764772
92ABL10.16397250
93EIF2AK20.16391796
94PRKD20.15622396
95EGFR0.14637906
96PTK2B0.14532485
97PIK3CG0.14135475
98RPS6KA60.13687920
99PRKCZ0.13127006
100CDK60.12482859

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.93258763
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.87013767
3Osteoclast differentiation_Homo sapiens_hsa043802.86486878
4Leishmaniasis_Homo sapiens_hsa051402.86486279
5Graft-versus-host disease_Homo sapiens_hsa053322.81131041
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.72597268
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.54584331
8Autoimmune thyroid disease_Homo sapiens_hsa053202.53725986
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.50837190
10Staphylococcus aureus infection_Homo sapiens_hsa051502.41289186
11Malaria_Homo sapiens_hsa051442.37854129
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.23518349
13TNF signaling pathway_Homo sapiens_hsa046682.17421996
14Legionellosis_Homo sapiens_hsa051342.16202907
15Rheumatoid arthritis_Homo sapiens_hsa053232.13078852
16Type I diabetes mellitus_Homo sapiens_hsa049402.12592702
17Asthma_Homo sapiens_hsa053102.12367122
18Primary immunodeficiency_Homo sapiens_hsa053402.11109067
19Measles_Homo sapiens_hsa051622.09730654
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06105257
21Tuberculosis_Homo sapiens_hsa051522.00031502
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.96664904
23African trypanosomiasis_Homo sapiens_hsa051431.95859498
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.81458822
25Influenza A_Homo sapiens_hsa051641.80271228
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75512529
27Pertussis_Homo sapiens_hsa051331.74407923
28Antigen processing and presentation_Homo sapiens_hsa046121.73163013
29Hematopoietic cell lineage_Homo sapiens_hsa046401.71685207
30T cell receptor signaling pathway_Homo sapiens_hsa046601.71504188
31Toxoplasmosis_Homo sapiens_hsa051451.65172742
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.56578024
33B cell receptor signaling pathway_Homo sapiens_hsa046621.56200486
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52208098
35Chemokine signaling pathway_Homo sapiens_hsa040621.49184462
36Herpes simplex infection_Homo sapiens_hsa051681.43382911
37Salmonella infection_Homo sapiens_hsa051321.43199412
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27576154
39Hepatitis C_Homo sapiens_hsa051601.27519632
40Viral myocarditis_Homo sapiens_hsa054161.22632792
41Hepatitis B_Homo sapiens_hsa051611.16996317
42Acute myeloid leukemia_Homo sapiens_hsa052211.14604482
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14326367
44Other glycan degradation_Homo sapiens_hsa005111.11653311
45Phagosome_Homo sapiens_hsa041451.05470876
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03362790
47Apoptosis_Homo sapiens_hsa042100.93370664
48Shigellosis_Homo sapiens_hsa051310.92399908
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90401593
50Lysosome_Homo sapiens_hsa041420.90206587
51Epstein-Barr virus infection_Homo sapiens_hsa051690.90004553
52Prolactin signaling pathway_Homo sapiens_hsa049170.87600169
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84851497
54Dorso-ventral axis formation_Homo sapiens_hsa043200.73796643
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73479366
56Prion diseases_Homo sapiens_hsa050200.73363704
57Amoebiasis_Homo sapiens_hsa051460.72814619
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.72477187
59VEGF signaling pathway_Homo sapiens_hsa043700.72079767
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59159086
61Type II diabetes mellitus_Homo sapiens_hsa049300.58979080
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.56362503
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55651275
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.53033290
65HTLV-I infection_Homo sapiens_hsa051660.52681247
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51642342
67Platelet activation_Homo sapiens_hsa046110.48975287
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.48888459
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46158781
70Collecting duct acid secretion_Homo sapiens_hsa049660.45414116
71Viral carcinogenesis_Homo sapiens_hsa052030.45201906
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43459849
73MAPK signaling pathway_Homo sapiens_hsa040100.42788822
74FoxO signaling pathway_Homo sapiens_hsa040680.41655186
75Pancreatic cancer_Homo sapiens_hsa052120.37482679
76Renal cell carcinoma_Homo sapiens_hsa052110.35111438
77Non-small cell lung cancer_Homo sapiens_hsa052230.34363852
78Insulin resistance_Homo sapiens_hsa049310.32332636
79Chronic myeloid leukemia_Homo sapiens_hsa052200.32132095
80Complement and coagulation cascades_Homo sapiens_hsa046100.32110341
81HIF-1 signaling pathway_Homo sapiens_hsa040660.31604240
82Notch signaling pathway_Homo sapiens_hsa043300.31020576
83Endocytosis_Homo sapiens_hsa041440.28914571
84Bladder cancer_Homo sapiens_hsa052190.28475020
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.28342889
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28209112
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28052372
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24045570
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16802329
90Prostate cancer_Homo sapiens_hsa052150.14354091
91Sphingolipid metabolism_Homo sapiens_hsa006000.13573969
92mTOR signaling pathway_Homo sapiens_hsa041500.13478562
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.13460620
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13407744
95GnRH signaling pathway_Homo sapiens_hsa049120.12953781
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.09653675
97Endometrial cancer_Homo sapiens_hsa052130.09607565
98Systemic lupus erythematosus_Homo sapiens_hsa053220.09264709
99Regulation of autophagy_Homo sapiens_hsa041400.08930558
100Rap1 signaling pathway_Homo sapiens_hsa040150.07869279

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