ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	4.49093148
2	DNA deamination (GO:0045006)	4.31740841
3	proline transport (GO:0015824)	4.10494649
4	adenosine metabolic process (GO:0046085)	3.93731844
5	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.92968181
6	gonadal mesoderm development (GO:0007506)	3.84141233
7	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.80629015
8	regulation of T cell receptor signaling pathway (GO:0050856)	3.64192837
9	protein-cofactor linkage (GO:0018065)	3.54526139
10	regulation of B cell receptor signaling pathway (GO:0050855)	3.48963220
11	platelet dense granule organization (GO:0060155)	3.44188261
12	organelle disassembly (GO:1903008)	3.42630019
13	cytidine deamination (GO:0009972)	3.37422428
14	cytidine metabolic process (GO:0046087)	3.37422428
15	cytidine catabolic process (GO:0006216)	3.37422428
16	axoneme assembly (GO:0035082)	3.37191767
17	regulation of hypersensitivity (GO:0002883)	3.37040713
18	T cell migration (GO:0072678)	3.36402747
19	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.28566120
20	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.27887912
21	protein neddylation (GO:0045116)	3.25755564
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.25381939
23	regulation of interleukin-1 beta secretion (GO:0050706)	3.22893921
24	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	3.21665665
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.08284714
26	positive regulation of interleukin-8 secretion (GO:2000484)	3.07719596
27	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.06736145
28	protein complex biogenesis (GO:0070271)	3.06664042
29	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.06397933
30	cellular ketone body metabolic process (GO:0046950)	3.03305496
31	aldehyde catabolic process (GO:0046185)	3.01566928
32	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.01516192
33	chemokine-mediated signaling pathway (GO:0070098)	3.01276136
34	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.99336399
35	ribonucleoprotein complex disassembly (GO:0032988)	2.98541521
36	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.94885648
37	ATP synthesis coupled proton transport (GO:0015986)	2.94885648
38	amino acid salvage (GO:0043102)	2.91674906
39	L-methionine salvage (GO:0071267)	2.91674906
40	L-methionine biosynthetic process (GO:0071265)	2.91674906
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.86111436
42	histone H2A acetylation (GO:0043968)	2.84451640
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.83992599
44	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.83992599
45	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.83598242
46	regulation of natural killer cell mediated immunity (GO:0002715)	2.83598242
47	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.80750039
48	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.79494386
49	regulation of germinal center formation (GO:0002634)	2.79376704
50	regulation of interleukin-1 secretion (GO:0050704)	2.78529522
51	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.78197947
52	tyrosine phosphorylation of STAT protein (GO:0007260)	2.78173143
53	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.77080934
54	negative regulation of cell killing (GO:0031342)	2.76715462
55	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.76715462
56	negative regulation of T cell apoptotic process (GO:0070233)	2.76332837
57	negative regulation of T cell receptor signaling pathway (GO:0050860)	2.75401972
58	one-carbon compound transport (GO:0019755)	2.73022877
59	positive regulation of T cell chemotaxis (GO:0010820)	2.72323151
60	regulation of T cell chemotaxis (GO:0010819)	2.72323151
61	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.71483312
62	positive regulation of lymphocyte migration (GO:2000403)	2.71032753
63	ketone body metabolic process (GO:1902224)	2.70645750
64	viral genome replication (GO:0019079)	2.69671461
65	regulation of lymphocyte chemotaxis (GO:1901623)	2.69098281
66	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.69007855
67	neutrophil activation involved in immune response (GO:0002283)	2.68298929
68	respiratory electron transport chain (GO:0022904)	2.67653889
69	negative regulation of mast cell activation (GO:0033004)	2.67485230
70	mitochondrial respiratory chain complex assembly (GO:0033108)	2.64019968
71	positive regulation of glycolytic process (GO:0045821)	2.62297218
72	detection of light stimulus involved in visual perception (GO:0050908)	2.61723473
73	detection of light stimulus involved in sensory perception (GO:0050962)	2.61723473
74	electron transport chain (GO:0022900)	2.61674337
75	positive regulation of interleukin-1 secretion (GO:0050716)	2.60757120
76	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.60752791
77	preassembly of GPI anchor in ER membrane (GO:0016254)	2.60220697
78	primary alcohol catabolic process (GO:0034310)	2.60158629
79	negative regulation of execution phase of apoptosis (GO:1900118)	2.59963712
80	cytochrome complex assembly (GO:0017004)	2.58746015
81	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.57700486
82	dendritic cell chemotaxis (GO:0002407)	2.56575170
83	sequestering of actin monomers (GO:0042989)	2.56170767
84	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.56094412
85	glyoxylate metabolic process (GO:0046487)	2.55809695
86	transmission of nerve impulse (GO:0019226)	2.55284193
87	dendritic cell migration (GO:0036336)	2.55182494
88	purine deoxyribonucleotide metabolic process (GO:0009151)	2.54535728
89	lymphocyte migration (GO:0072676)	2.54256481
90	positive regulation of antigen processing and presentation (GO:0002579)	2.53171225
91	auditory receptor cell stereocilium organization (GO:0060088)	2.52780789
92	cytolysis (GO:0019835)	2.51448897
93	positive regulation of cell killing (GO:0031343)	2.50708055
94	regulation of regulatory T cell differentiation (GO:0045589)	2.48420324
95	branched-chain amino acid catabolic process (GO:0009083)	2.46487354
96	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.44659859
97	positive regulation of interleukin-4 production (GO:0032753)	2.44521346
98	regulation of cell killing (GO:0031341)	2.43004906
99	regulation of cilium movement (GO:0003352)	2.42663211
100	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.41620309

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.23263787
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.23179568
3	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.01330520
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.91661102
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.60537633
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.48857331
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.44241856
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.35720274
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.34983118
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30494851
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.29927675
12	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.22572126
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.21248143
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.18340192
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.06338782
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.99968935
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.96990356
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.94624452
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94031314
20	VDR_22108803_ChIP-Seq_LS180_Human	1.84802341
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78755587
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.76926587
23	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.75293394
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74693045
25	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.72054296
26	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.70649207
27	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.68911118
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.68232779
29	GATA3_26560356_Chip-Seq_TH2_Human	1.67876060
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65919414
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.64986618
32	RUNX_20019798_ChIP-Seq_JUKART_Human	1.61504485
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58725837
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.57812151
35	MYB_26560356_Chip-Seq_TH2_Human	1.54895175
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.52823562
37	GATA3_27048872_Chip-Seq_THYMUS_Human	1.52571653
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50857070
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46122646
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46122646
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.46016496
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45560331
43	P300_19829295_ChIP-Seq_ESCs_Human	1.43146947
44	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.42715228
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.40611678
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.39277463
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39277463
48	FUS_26573619_Chip-Seq_HEK293_Human	1.38442568
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.37688551
50	EWS_26573619_Chip-Seq_HEK293_Human	1.37420418
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.37147866
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36543919
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.36540857
54	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.33699903
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.32595573
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.30773028
57	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.30032859
58	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29714000
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.26843788
60	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.24731365
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23437886
62	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.23156966
63	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.22039165
64	P53_22387025_ChIP-Seq_ESCs_Mouse	1.21446152
65	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21391194
66	AR_20517297_ChIP-Seq_VCAP_Human	1.21122263
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20568333
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20568333
69	GBX2_23144817_ChIP-Seq_PC3_Human	1.19038778
70	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.17351442
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15905435
72	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15223073
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.15211014
74	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.14585941
75	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13650352
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10173128
77	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09978428
78	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.08827775
79	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.08643517
80	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.08506098
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08106953
82	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.07016064
83	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06941755
84	P300_18555785_Chip-Seq_ESCs_Mouse	1.06832672
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.06774941
86	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06186937
87	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.05944816
88	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05900251
89	PU1_27457419_Chip-Seq_LIVER_Mouse	1.05502405
90	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.05160757
91	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04536670
92	NCOR_22424771_ChIP-Seq_293T_Human	1.04486077
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.03615882
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03152018
95	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02894394
96	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.02192952
97	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01100130
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00919677
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99525505
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.99386083

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.81263616
2	MP0002822_catalepsy	3.44279868
3	MP0002837_dystrophic_cardiac_calcinosis	3.42048589
4	MP0002163_abnormal_gland_morphology	3.18617634
5	MP0003806_abnormal_nucleotide_metabolis	2.94648224
6	MP0005379_endocrine/exocrine_gland_phen	2.92978854
7	MP0008877_abnormal_DNA_methylation	2.66755730
8	MP0006054_spinal_hemorrhage	2.53589952
9	MP0001835_abnormal_antigen_presentation	2.43485976
10	MP0003195_calcinosis	2.21846787
11	MP0006082_CNS_inflammation	2.21179116
12	MP0005645_abnormal_hypothalamus_physiol	2.21087671
13	MP0002102_abnormal_ear_morphology	2.15945083
14	MP0003045_fibrosis	2.12569046
15	MP0005075_abnormal_melanosome_morpholog	1.97566344
16	MP0004142_abnormal_muscle_tone	1.95221375
17	MP0006072_abnormal_retinal_apoptosis	1.91723528
18	MP0003787_abnormal_imprinting	1.91707518
19	MP0002876_abnormal_thyroid_physiology	1.87097906
20	MP0009785_altered_susceptibility_to	1.74944464
21	MP0003880_abnormal_central_pattern	1.72993217
22	MP0002139_abnormal_hepatobiliary_system	1.69967753
23	MP0002148_abnormal_hypersensitivity_rea	1.68951568
24	MP0001501_abnormal_sleep_pattern	1.68525663
25	MP0008995_early_reproductive_senescence	1.66441516
26	MP0001800_abnormal_humoral_immune	1.64365336
27	MP0005000_abnormal_immune_tolerance	1.62560873
28	MP0001764_abnormal_homeostasis	1.54787390
29	MP0005646_abnormal_pituitary_gland	1.52274107
30	MP0002693_abnormal_pancreas_physiology	1.49839067
31	MP0003866_abnormal_defecation	1.46840412
32	MP0005551_abnormal_eye_electrophysiolog	1.42158862
33	MP0003252_abnormal_bile_duct	1.41331085
34	MP0009745_abnormal_behavioral_response	1.41264093
35	MP0000516_abnormal_urinary_system	1.34652612
36	MP0005367_renal/urinary_system_phenotyp	1.34652612
37	MP0002723_abnormal_immune_serum	1.34322382
38	MP0009780_abnormal_chondrocyte_physiolo	1.30967934
39	MP0001727_abnormal_embryo_implantation	1.29295394
40	MP0001819_abnormal_immune_cell	1.26087714
41	MP0004147_increased_porphyrin_level	1.24971373
42	MP0002420_abnormal_adaptive_immunity	1.24681358
43	MP0002909_abnormal_adrenal_gland	1.24489822
44	MP0005085_abnormal_gallbladder_physiolo	1.24234948
45	MP0002166_altered_tumor_susceptibility	1.22750980
46	MP0002452_abnormal_antigen_presenting	1.22608756
47	MP0008872_abnormal_physiological_respon	1.20628693
48	MP0005253_abnormal_eye_physiology	1.19980377
49	MP0002254_reproductive_system_inflammat	1.18246126
50	MP0003011_delayed_dark_adaptation	1.11018403
51	MP0008961_abnormal_basal_metabolism	1.10076412
52	MP0009333_abnormal_splenocyte_physiolog	1.09673923
53	MP0003122_maternal_imprinting	1.09235885
54	MP0009764_decreased_sensitivity_to	1.09208765
55	MP0010386_abnormal_urinary_bladder	1.09145704
56	MP0008875_abnormal_xenobiotic_pharmacok	1.06790566
57	MP0005386_behavior/neurological_phenoty	1.06152984
58	MP0004924_abnormal_behavior	1.06152984
59	MP0005025_abnormal_response_to	1.05757560
60	MP0009046_muscle_twitch	1.05316645
61	MP0001986_abnormal_taste_sensitivity	1.02059422
62	MP0008789_abnormal_olfactory_epithelium	1.01506602
63	MP0006036_abnormal_mitochondrial_physio	0.98825497
64	MP0004145_abnormal_muscle_electrophysio	0.95464584
65	MP0002751_abnormal_autonomic_nervous	0.95277610
66	MP0004134_abnormal_chest_morphology	0.95219504
67	MP0005310_abnormal_salivary_gland	0.90545925
68	MP0002928_abnormal_bile_duct	0.90456745
69	MP0004043_abnormal_pH_regulation	0.89608738
70	MP0000689_abnormal_spleen_morphology	0.88748273
71	MP0001790_abnormal_immune_system	0.86298707
72	MP0005387_immune_system_phenotype	0.86298707
73	MP0003137_abnormal_impulse_conducting	0.85126655
74	MP0001905_abnormal_dopamine_level	0.84771876
75	MP0002272_abnormal_nervous_system	0.83883866
76	MP0002006_tumorigenesis	0.83065226
77	MP0000716_abnormal_immune_system	0.82886456
78	MP0002653_abnormal_ependyma_morphology	0.82758109
79	MP0001756_abnormal_urination	0.82153743
80	MP0004782_abnormal_surfactant_physiolog	0.82110997
81	MP0008469_abnormal_protein_level	0.81318291
82	MP0000639_abnormal_adrenal_gland	0.80763030
83	MP0001845_abnormal_inflammatory_respons	0.80398939
84	MP0003121_genomic_imprinting	0.80349531
85	MP0003448_altered_tumor_morphology	0.78639988
86	MP0002419_abnormal_innate_immunity	0.78099848
87	MP0005499_abnormal_olfactory_system	0.77668763
88	MP0005394_taste/olfaction_phenotype	0.77668763
89	MP0003763_abnormal_thymus_physiology	0.77038650
90	MP0003172_abnormal_lysosome_physiology	0.76311577
91	MP0002733_abnormal_thermal_nociception	0.76088879
92	MP0005332_abnormal_amino_acid	0.75286526
93	MP0000465_gastrointestinal_hemorrhage	0.74087268
94	MP0005535_abnormal_body_temperature	0.73052635
95	MP0003786_premature_aging	0.73021628
96	MP0002405_respiratory_system_inflammati	0.71663528
97	MP0004883_abnormal_blood_vessel	0.71555563
98	MP0004381_abnormal_hair_follicle	0.70790604
99	MP0000569_abnormal_digit_pigmentation	0.70307964
100	MP0002090_abnormal_vision	0.70136367

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	3.96143799
2	Hepatic necrosis (HP:0002605)	3.85926150
3	Hypoproteinemia (HP:0003075)	3.67077280
4	Mitochondrial inheritance (HP:0001427)	3.53331403
5	Renal cortical cysts (HP:0000803)	3.30312729
6	Acute necrotizing encephalopathy (HP:0006965)	3.29222871
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.18892924
8	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.18892924
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.17797517
10	Stomatitis (HP:0010280)	3.14010105
11	Medial flaring of the eyebrow (HP:0010747)	3.12702449
12	Acute encephalopathy (HP:0006846)	3.11909370
13	Chronic diarrhea (HP:0002028)	3.04711691
14	Progressive macrocephaly (HP:0004481)	3.00284226
15	Increased CSF lactate (HP:0002490)	2.86696781
16	Gait imbalance (HP:0002141)	2.74682873
17	Nephrogenic diabetes insipidus (HP:0009806)	2.72041053
18	Molar tooth sign on MRI (HP:0002419)	2.69395368
19	Abnormality of midbrain morphology (HP:0002418)	2.69395368
20	Palpitations (HP:0001962)	2.69299869
21	Abnormality of the renal cortex (HP:0011035)	2.66691419
22	Autoimmune hemolytic anemia (HP:0001890)	2.65481252
23	Congenital primary aphakia (HP:0007707)	2.58319909
24	Abnormality of T cell physiology (HP:0011840)	2.55887752
25	Methylmalonic acidemia (HP:0002912)	2.55694633
26	Congenital, generalized hypertrichosis (HP:0004540)	2.55359436
27	True hermaphroditism (HP:0010459)	2.54945066
28	Hemiplegia (HP:0002301)	2.54446399
29	Hypothermia (HP:0002045)	2.53497607
30	Emotional lability (HP:0000712)	2.52395000
31	Thyroiditis (HP:0100646)	2.47824992
32	Abnormality of T cells (HP:0002843)	2.46457105
33	Cerebral edema (HP:0002181)	2.44681736
34	Methylmalonic aciduria (HP:0012120)	2.42220866
35	Pancreatic fibrosis (HP:0100732)	2.42196872
36	Acute hepatic failure (HP:0006554)	2.40150914
37	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.39803306
38	Dicarboxylic aciduria (HP:0003215)	2.39803306
39	IgG deficiency (HP:0004315)	2.38981221
40	Hemiparesis (HP:0001269)	2.35258544
41	Limb dystonia (HP:0002451)	2.33312612
42	Chronic hepatic failure (HP:0100626)	2.33305775
43	Severe combined immunodeficiency (HP:0004430)	2.31383078
44	Increased intramyocellular lipid droplets (HP:0012240)	2.29146288
45	Abnormality of T cell number (HP:0011839)	2.24067521
46	J-shaped sella turcica (HP:0002680)	2.21071784
47	Myokymia (HP:0002411)	2.20153608
48	Pancreatic cysts (HP:0001737)	2.18432487
49	Combined immunodeficiency (HP:0005387)	2.15428815
50	Abnormality of eosinophils (HP:0001879)	2.15396025
51	Volvulus (HP:0002580)	2.14188851
52	T lymphocytopenia (HP:0005403)	2.09825926
53	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.09148152
54	IgM deficiency (HP:0002850)	2.08371664
55	Respiratory failure (HP:0002878)	2.08198286
56	Abnormality of the prostate (HP:0008775)	2.07287334
57	3-Methylglutaconic aciduria (HP:0003535)	2.06242774
58	CNS demyelination (HP:0007305)	2.06078260
59	Gastrointestinal infarctions (HP:0005244)	2.04723748
60	Lactic acidosis (HP:0003128)	2.02823077
61	Increased CSF protein (HP:0002922)	2.01562869
62	Generalized aminoaciduria (HP:0002909)	1.99523839
63	Diplopia (HP:0000651)	1.97679173
64	Abnormality of binocular vision (HP:0011514)	1.97679173
65	Eosinophilia (HP:0001880)	1.96401086
66	Congenital stationary night blindness (HP:0007642)	1.95070047
67	Increased muscle lipid content (HP:0009058)	1.94879769
68	Hypoglycemic coma (HP:0001325)	1.92605283
69	Intestinal atresia (HP:0011100)	1.88071663
70	Proximal tubulopathy (HP:0000114)	1.87983954
71	Nephronophthisis (HP:0000090)	1.87839244
72	Exertional dyspnea (HP:0002875)	1.87254401
73	Hyperglycinemia (HP:0002154)	1.86601126
74	Lethargy (HP:0001254)	1.86104679
75	Abnormal rod and cone electroretinograms (HP:0008323)	1.85888189
76	Abolished electroretinogram (ERG) (HP:0000550)	1.84595294
77	Elevated erythrocyte sedimentation rate (HP:0003565)	1.80635361
78	Constricted visual fields (HP:0001133)	1.79867318
79	Increased serum lactate (HP:0002151)	1.79274732
80	Recurrent bronchitis (HP:0002837)	1.78809955
81	Abnormality of macrophages (HP:0004311)	1.78561508
82	Pustule (HP:0200039)	1.76101261
83	Dyskinesia (HP:0100660)	1.75652091
84	Abnormal albumin level (HP:0012116)	1.75411442
85	Hypoalbuminemia (HP:0003073)	1.75411442
86	Leukodystrophy (HP:0002415)	1.75359478
87	Disinhibition (HP:0000734)	1.75228524
88	Abnormality of vitamin B metabolism (HP:0004340)	1.75060060
89	Micronodular cirrhosis (HP:0001413)	1.74463946
90	Bile duct proliferation (HP:0001408)	1.74428777
91	Abnormal biliary tract physiology (HP:0012439)	1.74428777
92	Attenuation of retinal blood vessels (HP:0007843)	1.73434397
93	Lipid accumulation in hepatocytes (HP:0006561)	1.73248760
94	Abnormal drinking behavior (HP:0030082)	1.73242143
95	Polydipsia (HP:0001959)	1.73242143
96	Large for gestational age (HP:0001520)	1.72209680
97	Ketoacidosis (HP:0001993)	1.71909659
98	Increased serum ferritin (HP:0003281)	1.69762747
99	Popliteal pterygium (HP:0009756)	1.68774397
100	Abnormality of B cell number (HP:0010975)	1.67492863

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	4.59898184
2	TXK	3.20546759
3	NEK1	3.03666195
4	FRK	3.01263675
5	EIF2AK3	2.50706334
6	BMPR2	2.43656623
7	MAP3K4	2.26093111
8	MAP4K1	2.24561821
9	BCR	2.17505872
10	EIF2AK1	2.10881967
11	BCKDK	2.02566158
12	PINK1	1.96328450
13	TNK2	1.91994051
14	MAPK13	1.66227346
15	FES	1.64889987
16	WNK3	1.63301375
17	ERBB3	1.63234835
18	UHMK1	1.62780709
19	CSNK1G3	1.55755735
20	CSNK1G2	1.54688134
21	STK16	1.53783774
22	MAP4K2	1.51052046
23	NUAK1	1.49971608
24	OXSR1	1.48747613
25	KDR	1.47435582
26	MAP3K2	1.42696080
27	MAP2K7	1.39190417
28	CDK19	1.38703677
29	PLK4	1.36974770
30	PLK2	1.36011164
31	ITK	1.24778313
32	CSNK1A1L	1.22861641
33	ZAK	1.21054092
34	CCNB1	1.20555930
35	PHKG2	1.15504615
36	PHKG1	1.15504615
37	MAP3K9	1.14956501
38	GRK1	1.13911102
39	CSNK1G1	1.10249005
40	KIT	1.06420039
41	MST4	1.00954427
42	EPHA3	1.00923875
43	TRIM28	1.00563426
44	TAOK3	0.99065762
45	LYN	0.96830826
46	ADRBK2	0.95562547
47	STK39	0.95268864
48	MAP3K12	0.95268645
49	ERBB2	0.93047211
50	NEK2	0.92150382
51	TEC	0.91917504
52	INSRR	0.84292926
53	SYK	0.83330853
54	MAP3K3	0.80113264
55	TIE1	0.77729069
56	PAK3	0.77188833
57	FLT3	0.76748801
58	JAK3	0.71331094
59	IKBKB	0.70703753
60	PRKCQ	0.68792266
61	TLK1	0.68534350
62	EIF2AK2	0.67279122
63	GRK7	0.66135088
64	MYLK	0.65631563
65	BTK	0.64812878
66	LCK	0.63850797
67	PRKCE	0.59630016
68	CSF1R	0.58252534
69	ILK	0.57979450
70	DAPK2	0.56053148
71	LIMK1	0.53719336
72	RPS6KA4	0.53684867
73	TYK2	0.52872943
74	SIK2	0.52296791
75	CSNK1A1	0.51745150
76	ABL1	0.50829221
77	HCK	0.50807026
78	SIK3	0.50769041
79	TESK2	0.50632630
80	STK38L	0.50621396
81	PTK2B	0.49363888
82	MINK1	0.49257465
83	IGF1R	0.49076809
84	PRKCG	0.48752205
85	IKBKE	0.46560456
86	CAMK2A	0.44348252
87	DYRK3	0.44314025
88	CDK14	0.39207926
89	DAPK1	0.39089658
90	BUB1	0.38080536
91	PRKACA	0.36602594
92	OBSCN	0.36390793
93	MKNK2	0.35248874
94	RPS6KA5	0.34318425
95	PRKCA	0.33879481
96	CSNK1D	0.33155149
97	MKNK1	0.31988363
98	STK24	0.29428617
99	ACVR1B	0.27594922
100	FER	0.27035501

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.64154464
2	Graft-versus-host disease_Homo sapiens_hsa05332	3.59752703
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.95420334
4	Type I diabetes mellitus_Homo sapiens_hsa04940	2.91699730
5	Allograft rejection_Homo sapiens_hsa05330	2.65375952
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.62346014
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.31238790
8	Asthma_Homo sapiens_hsa05310	2.28513739
9	Sulfur metabolism_Homo sapiens_hsa00920	2.17659474
10	Proteasome_Homo sapiens_hsa03050	2.12429386
11	Parkinsons disease_Homo sapiens_hsa05012	2.10661994
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.09696954
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.07581563
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.05356403
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.87622751
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.83676479
17	Propanoate metabolism_Homo sapiens_hsa00640	1.83646726
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.72855592
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.71877377
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.63842491
21	Alzheimers disease_Homo sapiens_hsa05010	1.56479669
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.45515518
23	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.42779878
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38571321
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.37268967
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.36882542
27	RNA polymerase_Homo sapiens_hsa03020	1.32011169
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.31113039
29	Butanoate metabolism_Homo sapiens_hsa00650	1.28038985
30	Caffeine metabolism_Homo sapiens_hsa00232	1.26939067
31	RNA degradation_Homo sapiens_hsa03018	1.24996068
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24919405
33	Fatty acid degradation_Homo sapiens_hsa00071	1.24144128
34	Phototransduction_Homo sapiens_hsa04744	1.23744378
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.20337948
36	Huntingtons disease_Homo sapiens_hsa05016	1.20304229
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.18900741
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.18312031
39	Peroxisome_Homo sapiens_hsa04146	1.16954516
40	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.15430912
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05102802
42	Homologous recombination_Homo sapiens_hsa03440	1.04981622
43	Nicotine addiction_Homo sapiens_hsa05033	1.00678269
44	Viral myocarditis_Homo sapiens_hsa05416	0.99989836
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.97084276
46	GABAergic synapse_Homo sapiens_hsa04727	0.95892162
47	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.94162076
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93673372
49	Morphine addiction_Homo sapiens_hsa05032	0.90378992
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88103918
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.87362224
52	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.87089957
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85775932
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.84647467
55	Regulation of autophagy_Homo sapiens_hsa04140	0.83739660
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.83678035
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83451791
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.81724356
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79758975
60	Taste transduction_Homo sapiens_hsa04742	0.73324371
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72907783
62	Retinol metabolism_Homo sapiens_hsa00830	0.72788541
63	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.70220405
64	Purine metabolism_Homo sapiens_hsa00230	0.69870264
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67980152
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67572248
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65640984
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65247460
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.64388551
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.63126785
71	Circadian entrainment_Homo sapiens_hsa04713	0.62844246
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58712465
73	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.58121847
74	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.58028823
75	Salmonella infection_Homo sapiens_hsa05132	0.56215477
76	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.55368106
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.55330186
78	Histidine metabolism_Homo sapiens_hsa00340	0.50692321
79	Fatty acid elongation_Homo sapiens_hsa00062	0.49225652
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.49061222
81	Legionellosis_Homo sapiens_hsa05134	0.47634039
82	Folate biosynthesis_Homo sapiens_hsa00790	0.47372645
83	Metabolic pathways_Homo sapiens_hsa01100	0.46877705
84	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44903252
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44799710
86	Measles_Homo sapiens_hsa05162	0.44719943
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43516854
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41620878
89	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.40866393
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39949047
91	Herpes simplex infection_Homo sapiens_hsa05168	0.37356090
92	Chemokine signaling pathway_Homo sapiens_hsa04062	0.34603840
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.34201856
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34082683
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34075271
96	Mismatch repair_Homo sapiens_hsa03430	0.32666566
97	Amphetamine addiction_Homo sapiens_hsa05031	0.31757410
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.28811098
99	Salivary secretion_Homo sapiens_hsa04970	0.26636681
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26000506

PTGES3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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