ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	9.41413259
2	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	7.93204193
3	neurotransmitter catabolic process (GO:0042135)	7.78117332
4	positive regulation of amino acid transport (GO:0051957)	6.86553345
5	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.72540866
6	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.72540866
7	intermediate filament organization (GO:0045109)	5.61129717
8	ionotropic glutamate receptor signaling pathway (GO:0035235)	5.60258477
9	positive regulation of synaptic transmission, GABAergic (GO:0032230)	5.51611723
10	regulation of energy homeostasis (GO:2000505)	5.33587995
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.00321972
12	axon regeneration (GO:0031103)	4.96590228
13	positive regulation of fatty acid beta-oxidation (GO:0032000)	4.64624329
14	sequestering of actin monomers (GO:0042989)	4.55729358
15	behavioral response to pain (GO:0048266)	4.50441076
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.44663953
17	ATP synthesis coupled proton transport (GO:0015986)	4.44663953
18	axon extension involved in axon guidance (GO:0048846)	4.27129014
19	neuron projection extension involved in neuron projection guidance (GO:1902284)	4.27129014
20	pyrimidine nucleobase catabolic process (GO:0006208)	4.23116309
21	anterograde axon cargo transport (GO:0008089)	4.22251703
22	gamma-aminobutyric acid transport (GO:0015812)	4.14188137
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.13203507
24	viral transcription (GO:0019083)	4.03184970
25	gonadal mesoderm development (GO:0007506)	4.02624638
26	glutamate receptor signaling pathway (GO:0007215)	4.02545254
27	axon development (GO:0061564)	3.97038108
28	translational termination (GO:0006415)	3.91090095
29	retinal ganglion cell axon guidance (GO:0031290)	3.74558279
30	membrane hyperpolarization (GO:0060081)	3.70406605
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.66968873
32	respiratory electron transport chain (GO:0022904)	3.66068021
33	regulation of timing of cell differentiation (GO:0048505)	3.58668608
34	regulation of mitochondrial translation (GO:0070129)	3.57786718
35	urinary tract smooth muscle contraction (GO:0014848)	3.57348610
36	sulfation (GO:0051923)	3.54784986
37	electron transport chain (GO:0022900)	3.54195234
38	protein complex biogenesis (GO:0070271)	3.48126289
39	maturation of SSU-rRNA (GO:0030490)	3.42227328
40	neuron projection regeneration (GO:0031102)	3.37821779
41	nucleobase catabolic process (GO:0046113)	3.37528912
42	negative chemotaxis (GO:0050919)	3.37231443
43	behavioral response to nicotine (GO:0035095)	3.36588712
44	synaptic transmission, cholinergic (GO:0007271)	3.34053747
45	positive regulation of fatty acid oxidation (GO:0046321)	3.24218026
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.23252067
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.23252067
48	NADH dehydrogenase complex assembly (GO:0010257)	3.23252067
49	intermediate filament cytoskeleton organization (GO:0045104)	3.22070505
50	neuronal action potential (GO:0019228)	3.21705994
51	ribosomal large subunit biogenesis (GO:0042273)	3.17359714
52	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.14212058
53	intermediate filament-based process (GO:0045103)	3.13184830
54	synaptic transmission, glutamatergic (GO:0035249)	3.11727739
55	male sex determination (GO:0030238)	3.10098300
56	cotranslational protein targeting to membrane (GO:0006613)	3.09812856
57	neurotransmitter metabolic process (GO:0042133)	3.08619640
58	mitochondrial respiratory chain complex assembly (GO:0033108)	3.06897682
59	protein targeting to ER (GO:0045047)	3.03641684
60	regulation of amino acid transport (GO:0051955)	3.03437909
61	positive regulation of amine transport (GO:0051954)	3.01864737
62	positive regulation of organic acid transport (GO:0032892)	3.01051128
63	translational elongation (GO:0006414)	2.99380674
64	ganglion development (GO:0061548)	2.98804253
65	somite development (GO:0061053)	2.96852097
66	regulation of development, heterochronic (GO:0040034)	2.94486037
67	membrane tubulation (GO:0097320)	2.93947173
68	lung-associated mesenchyme development (GO:0060484)	2.91766748
69	cellular protein complex disassembly (GO:0043624)	2.89492958
70	sleep (GO:0030431)	2.88908903
71	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.86803567
72	viral life cycle (GO:0019058)	2.85150276
73	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.84020026
74	response to corticosterone (GO:0051412)	2.82048617
75	regulation of mesoderm development (GO:2000380)	2.81255746
76	regulation of action potential (GO:0098900)	2.81092466
77	serotonin receptor signaling pathway (GO:0007210)	2.74507614
78	protein localization to endoplasmic reticulum (GO:0070972)	2.72272474
79	neuromuscular process controlling posture (GO:0050884)	2.71325631
80	glycoprotein biosynthetic process (GO:0009101)	2.70647816
81	neuron cell-cell adhesion (GO:0007158)	2.68605724
82	protein localization to cilium (GO:0061512)	2.66921350
83	regulation of synaptic transmission, GABAergic (GO:0032228)	2.65050007
84	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.62747508
85	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.62747508
86	cGMP-mediated signaling (GO:0019934)	2.62582893
87	positive regulation of meiosis (GO:0045836)	2.61184396
88	sex determination (GO:0007530)	2.60496405
89	neuron fate determination (GO:0048664)	2.59194016
90	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.58840174
91	positive regulation of action potential (GO:0045760)	2.57548221
92	carnitine shuttle (GO:0006853)	2.53396578
93	proteasome assembly (GO:0043248)	2.53037287
94	neuron-neuron synaptic transmission (GO:0007270)	2.52223816
95	aldehyde catabolic process (GO:0046185)	2.50312122
96	dopaminergic neuron differentiation (GO:0071542)	2.49043563
97	negative regulation of axon extension (GO:0030517)	2.48618188
98	positive regulation of response to oxidative stress (GO:1902884)	2.45695969
99	positive regulation of cellular response to oxidative stress (GO:1900409)	2.45695969
100	neurofilament cytoskeleton organization (GO:0060052)	10.4990081

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.42699405
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.37808921
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.17625392
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.24852814
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.81770589
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70298781
7	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.69274051
8	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.67088892
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.65244392
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.51793711
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.50543117
12	AR_21572438_ChIP-Seq_LNCaP_Human	2.37127406
13	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.31060239
14	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.27392883
15	IRF1_19129219_ChIP-ChIP_H3396_Human	2.21406467
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.20592635
17	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.20376138
18	VDR_22108803_ChIP-Seq_LS180_Human	2.16160684
19	FUS_26573619_Chip-Seq_HEK293_Human	2.15575444
20	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.09051878
21	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.08886134
22	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.08736712
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99469802
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98433446
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.97923892
26	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.95132943
27	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.87907529
28	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.87731425
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.85124870
30	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.82937833
31	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.82937833
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.82250762
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.80395709
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.79724580
35	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.71984127
36	EWS_26573619_Chip-Seq_HEK293_Human	1.69890633
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.67510641
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66562411
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65723179
40	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.63245911
41	REST_21632747_ChIP-Seq_MESCs_Mouse	1.60812841
42	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.60548026
43	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.60304031
44	ZNF274_21170338_ChIP-Seq_K562_Hela	1.59741167
45	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.57003455
46	P300_19829295_ChIP-Seq_ESCs_Human	1.56299422
47	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.54817719
48	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.52232031
49	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.50964037
50	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.50197277
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47557154
52	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.47068094
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46448292
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.39518295
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.37344655
56	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.32242859
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31175048
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.31111717
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.29492697
60	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.28985682
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.28925954
62	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.26767284
63	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26559244
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.26386266
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26386266
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25855766
67	AR_25329375_ChIP-Seq_VCAP_Human	1.25095589
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23011212
69	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22383373
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21710597
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21710597
72	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.18423401
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17454166
74	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17290836
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16026637
76	ER_23166858_ChIP-Seq_MCF-7_Human	1.14034381
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13562253
78	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12951208
79	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12841442
80	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.11415914
81	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.10779555
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.10702756
83	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.10317304
84	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10035842
85	RXR_22108803_ChIP-Seq_LS180_Human	1.08987354
86	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08477956
87	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05947341
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.02756183
89	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.01808416
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99772370
91	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99287300
92	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.98717034
93	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97928682
94	DROSHA_22980978_ChIP-Seq_HELA_Human	0.97087923
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95121694
96	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.94052591
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.93225325
98	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.92796352
99	SOX9_26525672_Chip-Seq_HEART_Mouse	0.92336230
100	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.90922214

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002735_abnormal_chemical_nociception	5.49203199
2	MP0000566_synostosis	4.85198827
3	MP0003136_yellow_coat_color	4.56706645
4	MP0002638_abnormal_pupillary_reflex	3.86907943
5	MP0009379_abnormal_foot_pigmentation	2.86957414
6	MP0000537_abnormal_urethra_morphology	2.75818354
7	MP0001970_abnormal_pain_threshold	2.48574155
8	MP0010386_abnormal_urinary_bladder	2.33243554
9	MP0006072_abnormal_retinal_apoptosis	2.28849658
10	MP0005646_abnormal_pituitary_gland	2.13948264
11	MP0002272_abnormal_nervous_system	2.13615506
12	MP0000569_abnormal_digit_pigmentation	2.10415669
13	MP0006292_abnormal_olfactory_placode	1.94442138
14	MP0009745_abnormal_behavioral_response	1.94326530
15	MP0005423_abnormal_somatic_nervous	1.91656015
16	MP0002837_dystrophic_cardiac_calcinosis	1.87921872
17	MP0002736_abnormal_nociception_after	1.86919061
18	MP0001968_abnormal_touch/_nociception	1.83295273
19	MP0002734_abnormal_mechanical_nocicepti	1.81018269
20	MP0008995_early_reproductive_senescence	1.76424052
21	MP0008877_abnormal_DNA_methylation	1.75497747
22	MP0000049_abnormal_middle_ear	1.74162626
23	MP0009046_muscle_twitch	1.69095843
24	MP0001486_abnormal_startle_reflex	1.66126917
25	MP0002822_catalepsy	1.65930732
26	MP0002234_abnormal_pharynx_morphology	1.63495304
27	MP0003878_abnormal_ear_physiology	1.61967597
28	MP0005377_hearing/vestibular/ear_phenot	1.61967597
29	MP0001485_abnormal_pinna_reflex	1.60922552
30	MP0005595_abnormal_vascular_smooth	1.59155656
31	MP0004885_abnormal_endolymph	1.53737236
32	MP0003635_abnormal_synaptic_transmissio	1.53438472
33	MP0002064_seizures	1.53305921
34	MP0005171_absent_coat_pigmentation	1.50935918
35	MP0004142_abnormal_muscle_tone	1.49524186
36	MP0004270_analgesia	1.43663330
37	MP0002733_abnormal_thermal_nociception	1.41875960
38	MP0000631_abnormal_neuroendocrine_gland	1.41566629
39	MP0002572_abnormal_emotion/affect_behav	1.40467171
40	MP0002139_abnormal_hepatobiliary_system	1.34783822
41	MP0010030_abnormal_orbit_morphology	1.34065479
42	MP0000026_abnormal_inner_ear	1.29974798
43	MP0004215_abnormal_myocardial_fiber	1.29609724
44	MP0002282_abnormal_trachea_morphology	1.29016527
45	MP0001963_abnormal_hearing_physiology	1.22602693
46	MP0002163_abnormal_gland_morphology	1.22282072
47	MP0001293_anophthalmia	1.19421202
48	MP0002184_abnormal_innervation	1.19126338
49	MP0002653_abnormal_ependyma_morphology	1.18083260
50	MP0001346_abnormal_lacrimal_gland	1.16032961
51	MP0005197_abnormal_uvea_morphology	1.14377114
52	MP0000778_abnormal_nervous_system	1.14337753
53	MP0003283_abnormal_digestive_organ	1.08960711
54	MP0002102_abnormal_ear_morphology	1.06426498
55	MP0001986_abnormal_taste_sensitivity	1.06277660
56	MP0004883_abnormal_blood_vessel	1.05710312
57	MP0006276_abnormal_autonomic_nervous	1.05567916
58	MP0004742_abnormal_vestibular_system	1.05523316
59	MP0002063_abnormal_learning/memory/cond	1.04229711
60	MP0003567_abnormal_fetal_cardiomyocyte	1.02243685
61	MP0003880_abnormal_central_pattern	1.01901598
62	MP0003890_abnormal_embryonic-extraembry	0.99757275
63	MP0009053_abnormal_anal_canal	0.99323600
64	MP0001756_abnormal_urination	0.98906328
65	MP0005174_abnormal_tail_pigmentation	0.98348579
66	MP0006138_congestive_heart_failure	0.96378195
67	MP0003755_abnormal_palate_morphology	0.94532108
68	MP0002557_abnormal_social/conspecific_i	0.94136462
69	MP0000516_abnormal_urinary_system	0.93281769
70	MP0005367_renal/urinary_system_phenotyp	0.93281769
71	MP0002752_abnormal_somatic_nervous	0.89049227
72	MP0002751_abnormal_autonomic_nervous	0.88187938
73	MP0003011_delayed_dark_adaptation	0.87807630
74	MP0002938_white_spotting	0.87222243
75	MP0002932_abnormal_joint_morphology	0.86435535
76	MP0000955_abnormal_spinal_cord	0.85485332
77	MP0003122_maternal_imprinting	0.84753018
78	MP0001440_abnormal_grooming_behavior	0.82918052
79	MP0003119_abnormal_digestive_system	0.82646677
80	MP0001286_abnormal_eye_development	0.79927743
81	MP0003121_genomic_imprinting	0.79804991
82	MP0004130_abnormal_muscle_cell	0.77446933
83	MP0000428_abnormal_craniofacial_morphol	0.77165839
84	MP0003633_abnormal_nervous_system	0.76204349
85	MP0002277_abnormal_respiratory_mucosa	0.75647523
86	MP0005253_abnormal_eye_physiology	0.73282399
87	MP0005503_abnormal_tendon_morphology	0.72799060
88	MP0005551_abnormal_eye_electrophysiolog	0.72677869
89	MP0002233_abnormal_nose_morphology	0.71521447
90	MP0002249_abnormal_larynx_morphology	0.70780264
91	MP0000372_irregular_coat_pigmentation	0.69704066
92	MP0003938_abnormal_ear_development	0.68924785
93	MP0001879_abnormal_lymphatic_vessel	0.67664387
94	MP0002067_abnormal_sensory_capabilities	0.66468763
95	MP0003631_nervous_system_phenotype	0.66214412
96	MP0008875_abnormal_xenobiotic_pharmacok	0.65218916
97	MP0000751_myopathy	0.64806901
98	MP0005085_abnormal_gallbladder_physiolo	0.63988430
99	MP0000462_abnormal_digestive_system	0.63724127
100	MP0000538_abnormal_urinary_bladder	0.63700896

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ulnar claw (HP:0001178)	9.28800063
2	Segmental peripheral demyelination/remyelination (HP:0003481)	5.72540796
3	Septo-optic dysplasia (HP:0100842)	4.54714228
4	Humeroradial synostosis (HP:0003041)	4.20928700
5	Synostosis involving the elbow (HP:0003938)	4.20928700
6	Acute encephalopathy (HP:0006846)	3.97195383
7	Congenital, generalized hypertrichosis (HP:0004540)	3.94342475
8	Atonic seizures (HP:0010819)	3.50980632
9	Acute necrotizing encephalopathy (HP:0006965)	3.44153473
10	Bradycardia (HP:0001662)	3.31207730
11	Symphalangism affecting the phalanges of the hand (HP:0009773)	3.28696250
12	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	3.06697738
13	Onion bulb formation (HP:0003383)	3.02064934
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.01924480
15	3-Methylglutaconic aciduria (HP:0003535)	2.89449255
16	Progressive macrocephaly (HP:0004481)	2.83479477
17	Focal motor seizures (HP:0011153)	2.83023228
18	Hyperglycinemia (HP:0002154)	2.80486193
19	Absent septum pellucidum (HP:0001331)	2.75359859
20	Mitochondrial inheritance (HP:0001427)	2.72108178
21	Steppage gait (HP:0003376)	2.67100609
22	Optic nerve hypoplasia (HP:0000609)	2.57934463
23	Decreased motor nerve conduction velocity (HP:0003431)	2.57222143
24	Atrial fibrillation (HP:0005110)	2.56362833
25	Bilateral microphthalmos (HP:0007633)	2.54606115
26	Morphological abnormality of the pyramidal tract (HP:0002062)	2.53517451
27	Foot dorsiflexor weakness (HP:0009027)	2.52330125
28	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.49846079
29	Hypothermia (HP:0002045)	2.45940419
30	Reticulocytopenia (HP:0001896)	2.45686105
31	Rib fusion (HP:0000902)	2.38181312
32	Maternal diabetes (HP:0009800)	2.38053816
33	Abnormality of the foot musculature (HP:0001436)	2.37134428
34	Leukodystrophy (HP:0002415)	2.36466700
35	Increased CSF lactate (HP:0002490)	2.31022212
36	Lipid accumulation in hepatocytes (HP:0006561)	2.30048409
37	Febrile seizures (HP:0002373)	2.30042137
38	Congenital stationary night blindness (HP:0007642)	2.25175068
39	Increased hepatocellular lipid droplets (HP:0006565)	2.24508577
40	Primary atrial arrhythmia (HP:0001692)	2.20500395
41	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.18573613
42	Abnormality of the septum pellucidum (HP:0007375)	2.17421473
43	Abnormality of cells of the erythroid lineage (HP:0012130)	2.16803264
44	Hammertoe (HP:0001765)	2.15998699
45	Large for gestational age (HP:0001520)	2.15282263
46	Anophthalmia (HP:0000528)	2.15196173
47	Small hand (HP:0200055)	2.14945019
48	Birth length less than 3rd percentile (HP:0003561)	2.12919491
49	Abnormal ciliary motility (HP:0012262)	2.11708670
50	Parakeratosis (HP:0001036)	2.10887898
51	Supraventricular tachycardia (HP:0004755)	2.09964355
52	Focal seizures (HP:0007359)	2.09900692
53	Gonadotropin excess (HP:0000837)	2.09028466
54	Lower limb amyotrophy (HP:0007210)	2.05556863
55	Palpitations (HP:0001962)	2.05547255
56	Medial flaring of the eyebrow (HP:0010747)	2.04023353
57	Peripheral demyelination (HP:0011096)	2.03801046
58	Supraventricular arrhythmia (HP:0005115)	2.03068104
59	Stomach cancer (HP:0012126)	2.02424104
60	Dyskinesia (HP:0100660)	2.02115230
61	Esophageal atresia (HP:0002032)	2.02012189
62	Hypoplasia of the pons (HP:0012110)	2.01937472
63	Limb dystonia (HP:0002451)	2.01392397
64	Absence seizures (HP:0002121)	1.99654699
65	Absent/shortened dynein arms (HP:0200106)	1.97695536
66	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.97695536
67	Difficulty climbing stairs (HP:0003551)	1.97198807
68	Abnormal respiratory motile cilium physiology (HP:0012261)	1.96768221
69	Sclerocornea (HP:0000647)	1.92564584
70	Macrocytic anemia (HP:0001972)	1.88846702
71	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.87673511
72	Calf muscle hypertrophy (HP:0008981)	1.86265262
73	Pancreatic cysts (HP:0001737)	1.85510450
74	Cerebral edema (HP:0002181)	1.84847342
75	Concave nail (HP:0001598)	1.84756967
76	Dialeptic seizures (HP:0011146)	1.83616347
77	Abnormality of the musculature of the hand (HP:0001421)	1.82600838
78	Genu varum (HP:0002970)	1.82449801
79	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.81756423
80	Short hallux (HP:0010109)	1.80118270
81	Renal Fanconi syndrome (HP:0001994)	1.76727956
82	Gait imbalance (HP:0002141)	1.75212982
83	Anosmia (HP:0000458)	1.74279830
84	Myotonia (HP:0002486)	1.72696338
85	Abnormality of the middle phalanges of the toes (HP:0010183)	1.72448649
86	Muscle hypertrophy of the lower extremities (HP:0008968)	1.71527375
87	Abnormal number of erythroid precursors (HP:0012131)	1.70061743
88	Skin nodule (HP:0200036)	1.69411572
89	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.69121819
90	Vaginal atresia (HP:0000148)	1.68229928
91	Abnormality of the pons (HP:0007361)	1.67718989
92	Hyperglycinuria (HP:0003108)	1.67234702
93	Mesomelia (HP:0003027)	1.67187876
94	Growth hormone deficiency (HP:0000824)	1.66434073
95	Congenital primary aphakia (HP:0007707)	1.66343620
96	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.65356588
97	Optic disc pallor (HP:0000543)	1.64976443
98	Woolly hair (HP:0002224)	1.63269540
99	Osteomalacia (HP:0002749)	1.61330942
100	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.59965288

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	4.34369527
2	SIK2	4.00014777
3	ACVR1B	3.90005495
4	MARK1	2.98655014
5	WNK3	2.74601731
6	TYRO3	2.68390412
7	CASK	2.58959068
8	PINK1	2.52307207
9	RIPK1	2.41593405
10	VRK1	2.39873637
11	PNCK	2.18113787
12	MAPK15	2.17224500
13	ZAK	2.01875153
14	TGFBR1	1.93395187
15	PIK3CA	1.76935069
16	SIK1	1.67751675
17	TIE1	1.65128491
18	ERBB2	1.63817623
19	ARAF	1.62148155
20	TAF1	1.56472546
21	VRK2	1.55988137
22	WNK1	1.50884977
23	DYRK2	1.41549589
24	PRKCG	1.37630639
25	GRK7	1.26763704
26	WEE1	1.24754352
27	EPHB2	1.24378403
28	TSSK6	1.17604061
29	MST4	1.15100077
30	GRK1	1.13655439
31	TNK2	1.13323942
32	TLK1	1.02855768
33	STK16	0.91012310
34	NME1	0.90100932
35	MAP2K1	0.86739289
36	ADRBK2	0.85682158
37	CAMK2A	0.85162645
38	STK11	0.84076436
39	TAOK3	0.83793850
40	TNIK	0.83500923
41	RPS6KA6	0.81564184
42	CDK8	0.80759987
43	MAP3K7	0.80174359
44	PASK	0.78368544
45	TXK	0.76420439
46	MINK1	0.74899043
47	RPS6KA2	0.72320439
48	CAMK2G	0.70916031
49	CDK3	0.70518820
50	BLK	0.70480708
51	MAP4K2	0.70265083
52	INSRR	0.68733672
53	RPS6KL1	0.67300709
54	RPS6KC1	0.67300709
55	CDK5	0.64664783
56	OBSCN	0.63091016
57	PRKCE	0.62617303
58	BUB1	0.62402513
59	CSNK1E	0.61783664
60	ADRBK1	0.60299911
61	WNK4	0.59935724
62	MELK	0.59756010
63	DYRK1A	0.59743772
64	MAP3K4	0.59740868
65	PHKG1	0.59388153
66	PHKG2	0.59388153
67	GSK3A	0.59143253
68	ERBB4	0.58860607
69	PRKACA	0.58724469
70	PLK4	0.58622813
71	CSNK1A1	0.57409183
72	CDC7	0.56497969
73	FRK	0.56027534
74	PIM2	0.54301479
75	BCR	0.53962040
76	MAP2K6	0.53521535
77	PRKACB	0.53157394
78	PRKACG	0.52410224
79	SGK2	0.52034362
80	PLK3	0.49900184
81	PRKCH	0.49200051
82	RPS6KA5	0.48936117
83	RPS6KB1	0.47361883
84	SGK223	0.47273433
85	SGK494	0.47273433
86	AURKA	0.46358309
87	PDGFRB	0.46068767
88	CSNK2A2	0.45652101
89	MAPK4	0.45452830
90	LATS2	0.43858832
91	UHMK1	0.43746329
92	EIF2AK2	0.43377049
93	INSR	0.43374030
94	AURKB	0.42506872
95	PRKCA	0.40821934
96	ABL2	0.40215487
97	CHEK2	0.39976864
98	MAP3K9	0.36883075
99	RPS6KA1	0.36506751
100	SRPK1	0.36263748

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.39619961
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.16830420
3	Parkinsons disease_Homo sapiens_hsa05012	3.54187094
4	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	3.14525005
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.92735832
6	Nicotine addiction_Homo sapiens_hsa05033	2.89835462
7	Alzheimers disease_Homo sapiens_hsa05010	2.86586545
8	Taste transduction_Homo sapiens_hsa04742	2.52374497
9	Huntingtons disease_Homo sapiens_hsa05016	2.47453237
10	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.37907416
11	Proteasome_Homo sapiens_hsa03050	1.95765538
12	Homologous recombination_Homo sapiens_hsa03440	1.94391807
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.82495334
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.78275450
15	Phototransduction_Homo sapiens_hsa04744	1.65426830
16	Glutamatergic synapse_Homo sapiens_hsa04724	1.60448810
17	RNA degradation_Homo sapiens_hsa03018	1.59895568
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.55375940
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.50521701
20	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.48587625
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.42400742
22	RNA polymerase_Homo sapiens_hsa03020	1.40076201
23	GABAergic synapse_Homo sapiens_hsa04727	1.37279497
24	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.37164620
25	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.34391586
26	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.26829188
27	Morphine addiction_Homo sapiens_hsa05032	1.21286559
28	Mismatch repair_Homo sapiens_hsa03430	1.20417022
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.19732212
30	Olfactory transduction_Homo sapiens_hsa04740	1.16596048
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.14340972
32	Protein export_Homo sapiens_hsa03060	1.14083517
33	Sulfur metabolism_Homo sapiens_hsa00920	1.12515171
34	Circadian entrainment_Homo sapiens_hsa04713	1.04163577
35	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.01865908
36	Basal cell carcinoma_Homo sapiens_hsa05217	0.98755757
37	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96575319
38	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.95684842
39	Alcoholism_Homo sapiens_hsa05034	0.95594033
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.93777383
41	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.90888330
42	Retinol metabolism_Homo sapiens_hsa00830	0.90469530
43	Cocaine addiction_Homo sapiens_hsa05030	0.90218123
44	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.89040874
45	Dopaminergic synapse_Homo sapiens_hsa04728	0.81980325
46	Cholinergic synapse_Homo sapiens_hsa04725	0.79531902
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79273998
48	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.78334663
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.77108040
50	Insulin secretion_Homo sapiens_hsa04911	0.76623564
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.75449940
52	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.75030352
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74724457
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74702315
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.73923786
56	Spliceosome_Homo sapiens_hsa03040	0.70943434
57	Circadian rhythm_Homo sapiens_hsa04710	0.68543447
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.67215008
59	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.66440354
60	Amphetamine addiction_Homo sapiens_hsa05031	0.65751926
61	DNA replication_Homo sapiens_hsa03030	0.64631346
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.64379087
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59882400
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59531027
65	Serotonergic synapse_Homo sapiens_hsa04726	0.56918549
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.56141168
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55085467
68	Glutathione metabolism_Homo sapiens_hsa00480	0.53657832
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50306046
70	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.49977501
71	Salivary secretion_Homo sapiens_hsa04970	0.47565514
72	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.47513867
73	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.46499742
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.43243421
75	Bile secretion_Homo sapiens_hsa04976	0.41914082
76	Pancreatic secretion_Homo sapiens_hsa04972	0.41158791
77	Purine metabolism_Homo sapiens_hsa00230	0.40552840
78	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.40061916
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.38898702
80	RNA transport_Homo sapiens_hsa03013	0.38444575
81	Gastric acid secretion_Homo sapiens_hsa04971	0.38084597
82	Axon guidance_Homo sapiens_hsa04360	0.36791054
83	Melanoma_Homo sapiens_hsa05218	0.36688670
84	Oocyte meiosis_Homo sapiens_hsa04114	0.35844366
85	Asthma_Homo sapiens_hsa05310	0.35779302
86	Renin-angiotensin system_Homo sapiens_hsa04614	0.35584184
87	Gap junction_Homo sapiens_hsa04540	0.35248168
88	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.34916374
89	Caffeine metabolism_Homo sapiens_hsa00232	0.33404636
90	Metabolic pathways_Homo sapiens_hsa01100	0.32950178
91	Wnt signaling pathway_Homo sapiens_hsa04310	0.32571717
92	Basal transcription factors_Homo sapiens_hsa03022	0.32133683
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30173837
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.29705476
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.28422865
96	Melanogenesis_Homo sapiens_hsa04916	0.28120999
97	Nitrogen metabolism_Homo sapiens_hsa00910	0.27925605
98	Rap1 signaling pathway_Homo sapiens_hsa04015	0.26540784
99	Tryptophan metabolism_Homo sapiens_hsa00380	0.26022058
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24000797

PTGES3P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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