PTGFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1estrogen biosynthetic process (GO:0006703)7.98179345
2protein heterotrimerization (GO:0070208)6.16129793
3collagen fibril organization (GO:0030199)5.42082215
4neurofilament cytoskeleton organization (GO:0060052)5.38897657
5mesenchymal-epithelial cell signaling (GO:0060638)4.96846965
6axonemal dynein complex assembly (GO:0070286)4.75631008
7cell migration involved in heart development (GO:0060973)4.69970268
8cellular response to cadmium ion (GO:0071276)4.64005919
9estrogen metabolic process (GO:0008210)4.60081542
10fibril organization (GO:0097435)4.50981553
11response to follicle-stimulating hormone (GO:0032354)4.46393796
12epoxygenase P450 pathway (GO:0019373)4.33108845
13bone trabecula formation (GO:0060346)4.30522909
14androgen biosynthetic process (GO:0006702)4.21034165
15sequestering of extracellular ligand from receptor (GO:0035581)4.18733472
16cellular response to interferon-alpha (GO:0035457)4.05888665
17type B pancreatic cell proliferation (GO:0044342)4.04627433
18cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.02457086
19cilium or flagellum-dependent cell motility (GO:0001539)3.98965033
20cellular response to vitamin (GO:0071295)3.92314822
21chondrocyte proliferation (GO:0035988)3.90154381
22blood vessel maturation (GO:0001955)3.85820495
23peptidyl-proline hydroxylation (GO:0019511)3.64799354
24neuron projection extension involved in neuron projection guidance (GO:1902284)3.62298254
25axon extension involved in axon guidance (GO:0048846)3.62298254
26collagen metabolic process (GO:0032963)3.60943885
27collagen catabolic process (GO:0030574)3.60281797
28glucosamine-containing compound catabolic process (GO:1901072)3.55805920
29embryonic cranial skeleton morphogenesis (GO:0048701)3.53660245
30regulation of tight junction assembly (GO:2000810)3.47969083
31regulation of extracellular matrix disassembly (GO:0010715)3.45387526
32regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.44959525
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.44240735
34plasma membrane repair (GO:0001778)3.42155191
35negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.41849737
36multicellular organismal macromolecule metabolic process (GO:0044259)3.37727987
37cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.34660352
38protein hydroxylation (GO:0018126)3.33275572
39positive regulation of smoothened signaling pathway (GO:0045880)3.32497366
40tooth mineralization (GO:0034505)3.31703642
41keratan sulfate catabolic process (GO:0042340)3.30143783
42multicellular organismal catabolic process (GO:0044243)3.29977655
43positive regulation of extracellular matrix organization (GO:1903055)3.26330623
44dermatan sulfate biosynthetic process (GO:0030208)3.26133314
45cell adhesion mediated by integrin (GO:0033627)3.22756928
46negative regulation of fatty acid transport (GO:2000192)3.22590422
47establishment of planar polarity (GO:0001736)3.22024045
48establishment of tissue polarity (GO:0007164)3.22024045
49multicellular organismal metabolic process (GO:0044236)3.21596213
50metanephric mesenchyme development (GO:0072075)3.21508957
51barbed-end actin filament capping (GO:0051016)3.20425690
52cellular response to vitamin D (GO:0071305)3.20393673
53endodermal cell differentiation (GO:0035987)3.19769255
54activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.18588075
55cilium movement (GO:0003341)3.18453180
56substrate-dependent cell migration (GO:0006929)3.18355819
57regulation of plasminogen activation (GO:0010755)3.18006982
58middle ear morphogenesis (GO:0042474)3.15163025
59COPI coating of Golgi vesicle (GO:0048205)3.14596337
60Golgi transport vesicle coating (GO:0048200)3.14596337
61chondrocyte development (GO:0002063)3.11442081
62adhesion of symbiont to host (GO:0044406)3.08121565
63basement membrane organization (GO:0071711)3.07642023
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.04633304
65left/right pattern formation (GO:0060972)3.02962030
66positive regulation of blood vessel endothelial cell migration (GO:0043536)2.99550025
67vascular endothelial growth factor signaling pathway (GO:0038084)2.98325010
68cellular response to growth hormone stimulus (GO:0071378)2.97894470
69extracellular matrix organization (GO:0030198)2.96368804
70iron ion import (GO:0097286)2.95854153
71extracellular structure organization (GO:0043062)2.95212666
72protein targeting to plasma membrane (GO:0072661)2.94199902
73dermatan sulfate metabolic process (GO:0030205)2.94092696
74negative regulation of homotypic cell-cell adhesion (GO:0034111)2.93918470
75cell migration involved in sprouting angiogenesis (GO:0002042)2.93826256
76cellular response to antibiotic (GO:0071236)2.93672804
77muscle cell migration (GO:0014812)2.92703845
78protein retention in ER lumen (GO:0006621)2.92359438
79motile cilium assembly (GO:0044458)2.92281906
80positive regulation of fibroblast migration (GO:0010763)2.92125948
81regulation of metalloenzyme activity (GO:0048552)2.90610821
82negative regulation of smooth muscle cell migration (GO:0014912)2.88476572
83regulation of integrin-mediated signaling pathway (GO:2001044)2.87976932
84negative regulation of dendrite morphogenesis (GO:0050774)2.86990218
85hypotonic response (GO:0006971)2.85084948
86skin morphogenesis (GO:0043589)2.84547786
87kidney mesenchyme development (GO:0072074)2.84244222
88smooth muscle tissue development (GO:0048745)2.83863856
89outer ear morphogenesis (GO:0042473)2.82189071
90positive regulation of fatty acid beta-oxidation (GO:0032000)2.81914718
91extracellular matrix disassembly (GO:0022617)2.81581611
92positive regulation of endothelial cell apoptotic process (GO:2000353)2.80122966
93maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.79657904
94protein localization to cell surface (GO:0034394)2.79160613
95regulation of glucose import in response to insulin stimulus (GO:2001273)2.79019058
96mating behavior (GO:0007617)2.77885430
97regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76732964
98organ induction (GO:0001759)2.76402339
99desmosome organization (GO:0002934)2.74889218
100positive regulation of mesenchymal cell proliferation (GO:0002053)2.74795925
101phosphate ion homeostasis (GO:0055062)2.74732889
102trivalent inorganic anion homeostasis (GO:0072506)2.74732889
103regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.74418958
104intermediate filament organization (GO:0045109)2.74211044
105import into cell (GO:0098657)2.73409393
106negative regulation of chondrocyte differentiation (GO:0032331)2.72897575
107apoptotic cell clearance (GO:0043277)2.72529726
108primary alcohol catabolic process (GO:0034310)2.71764005
109negative regulation of BMP signaling pathway (GO:0030514)2.71413382
110Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.71251338
111positive regulation of fatty acid oxidation (GO:0046321)2.71251128
112vitamin D metabolic process (GO:0042359)2.68245584
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67929025
114extracellular matrix assembly (GO:0085029)2.67863618
115endocardial cushion development (GO:0003197)2.67230170
116cellular response to amino acid stimulus (GO:0071230)2.66506958
117extracellular fibril organization (GO:0043206)2.65696839
118COPII vesicle coating (GO:0048208)2.65250655
119regulation of axon extension involved in axon guidance (GO:0048841)2.64290922
120negative regulation of leukocyte chemotaxis (GO:0002689)2.64255882
121glomerular epithelial cell development (GO:0072310)2.64095026
122regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62500484
123wound healing, spreading of epidermal cells (GO:0035313)2.62411432
124progesterone metabolic process (GO:0042448)2.62183033
125response to gonadotropin (GO:0034698)2.60064547
126peripheral nervous system neuron development (GO:0048935)2.59948145
127glomerular basement membrane development (GO:0032836)2.59339959
128regulation of establishment of planar polarity (GO:0090175)2.59200771
129protein localization to endosome (GO:0036010)2.58704006
130adhesion of symbiont to host cell (GO:0044650)2.55734001
131virion attachment to host cell (GO:0019062)2.55734001
132positive regulation of axon extension (GO:0045773)2.55255039
133extracellular negative regulation of signal transduction (GO:1900116)2.53400091
134extracellular regulation of signal transduction (GO:1900115)2.53400091
135peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.53085759
136C21-steroid hormone biosynthetic process (GO:0006700)2.53076777
137cellular response to gonadotropin stimulus (GO:0071371)2.53000228
138craniofacial suture morphogenesis (GO:0097094)2.52476294
139cell migration in hindbrain (GO:0021535)2.52392946
140retina vasculature morphogenesis in camera-type eye (GO:0061299)2.51830320
141response to corticosterone (GO:0051412)2.50591757
1424-hydroxyproline metabolic process (GO:0019471)2.50398893
143positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.49593986
144regulation of mesenchymal cell proliferation (GO:0010464)2.49301157
145negative regulation of striated muscle cell apoptotic process (GO:0010664)2.48949914
146decidualization (GO:0046697)2.48679916
147axis elongation (GO:0003401)2.47733540
148regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.46992897
149negative regulation of fibroblast apoptotic process (GO:2000270)2.45922265
150glucocorticoid metabolic process (GO:0008211)2.45424828
151insulin-like growth factor receptor signaling pathway (GO:0048009)2.43833927
152toxin metabolic process (GO:0009404)2.43761442
153response to phenylpropanoid (GO:0080184)2.42544064
154trabecula formation (GO:0060343)2.42192522
155prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.39087411
156planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37043358
157regulation of gonadotropin secretion (GO:0032276)2.36600202
158omega-hydroxylase P450 pathway (GO:0097267)2.36591030
159regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.35078300
160negative regulation of platelet activation (GO:0010544)2.33975156
161vasculature development (GO:0001944)2.33046642
162artery development (GO:0060840)2.32129732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.63214974
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.21426152
3WT1_19549856_ChIP-ChIP_CCG9911_Human2.93259696
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.77274427
5* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.62951667
6CLOCK_20551151_ChIP-Seq_293T_Human2.58296607
7* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.46184671
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42032972
9NRF2_20460467_ChIP-Seq_MEFs_Mouse2.30956011
10NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.30956011
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21764636
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.18636160
13CJUN_26792858_Chip-Seq_BT549_Human2.18633728
14GBX2_23144817_ChIP-Seq_PC3_Human2.18290281
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15649177
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15649177
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09779371
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04347770
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03745078
20* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02783236
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.00754984
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.88888608
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85222434
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81965149
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80781927
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.80106611
27* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.79934017
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75638111
29TP53_18474530_ChIP-ChIP_U2OS_Human1.73148175
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71824551
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.71512255
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70444974
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68926258
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.68194759
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.67411556
36TP53_16413492_ChIP-PET_HCT116_Human1.63458909
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63030265
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62771930
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62320651
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.59669228
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59542446
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54484372
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54335507
44* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54115945
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53845156
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47704873
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.45926543
48BCAT_22108803_ChIP-Seq_LS180_Human1.44153529
49BRD4_25478319_ChIP-Seq_HGPS_Human1.43447847
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41625670
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41131962
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39163420
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36457317
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36457317
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36232971
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32239907
57SMC1_22415368_ChIP-Seq_MEFs_Mouse1.30034683
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.29395132
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.28579697
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24417745
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24190088
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24108672
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.23611359
64AR_21572438_ChIP-Seq_LNCaP_Human1.22157363
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20574593
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20545755
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19838322
68SOX2_20726797_ChIP-Seq_SW620_Human1.19780847
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19433233
70AHR_22903824_ChIP-Seq_MCF-7_Human1.17645174
71SA1_22415368_ChIP-Seq_MEFs_Mouse1.17370883
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16998783
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16919529
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16742696
75RXR_22108803_ChIP-Seq_LS180_Human1.16602242
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16495174
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14718750
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14445535
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14211796
80* ELK3_25401928_ChIP-Seq_HUVEC_Human1.13818585
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13781580
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.13759443
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13670426
84JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12665402
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12209543
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12084503
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11121533
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10553029
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10258447
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10036379
91* SMAD4_21799915_ChIP-Seq_A2780_Human1.09920365
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09659638
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.09019406
94* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08362459
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07170321
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06432476
97TP53_23651856_ChIP-Seq_MEFs_Mouse1.04298760
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03659566
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.03356407
100TBX20_22080862_ChIP-Seq_HEART_Mouse1.03356407
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02096422
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01668483
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01491228
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01367630
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00624785
106ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99928242
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99090985
108* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98123269
109AR_25329375_ChIP-Seq_VCAP_Human0.97641287
110TP53_22127205_ChIP-Seq_IMR90_Human0.96188705
111TP63_23658742_ChIP-Seq_EP156T_Human0.95689672
112NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95119990
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.94845490
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94076672
115P300_19829295_ChIP-Seq_ESCs_Human0.93847195
116ZNF274_21170338_ChIP-Seq_K562_Hela0.92650593
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91866357
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91705796
119* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90744313
120SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90254429
121* RXR_22158963_ChIP-Seq_LIVER_Mouse0.89546721
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88389805
123* LXR_22158963_ChIP-Seq_LIVER_Mouse0.87980529
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87676936
125PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.86898471
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86363281
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86335396
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85938074
129EZH2_27294783_Chip-Seq_ESCs_Mouse0.85336207
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84928911
131RING1B_27294783_Chip-Seq_ESCs_Mouse0.84873624

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.79759822
2MP0005275_abnormal_skin_tensile5.58421484
3MP0005503_abnormal_tendon_morphology5.34736538
4MP0003705_abnormal_hypodermis_morpholog3.51468883
5MP0009384_cardiac_valve_regurgitation3.41785123
6MP0003279_aneurysm3.28911450
7MP0001958_emphysema3.15643159
8MP0003950_abnormal_plasma_membrane2.63024119
9MP0000751_myopathy2.17159962
10MP0004272_abnormal_basement_membrane2.04198361
11MP0005623_abnormal_meninges_morphology1.93981289
12MP0001299_abnormal_eye_distance/1.92700454
13MP0003195_calcinosis1.90624171
14MP0002295_abnormal_pulmonary_circulatio1.89666236
15MP0002896_abnormal_bone_mineralization1.83905952
16MP0002108_abnormal_muscle_morphology1.83266527
17MP0009250_abnormal_appendicular_skeleto1.79891704
18MP0002060_abnormal_skin_morphology1.72780737
19MP0004858_abnormal_nervous_system1.62886274
20MP0005508_abnormal_skeleton_morphology1.57836651
21MP0005257_abnormal_intraocular_pressure1.54909069
22MP0005023_abnormal_wound_healing1.52092446
23MP0004084_abnormal_cardiac_muscle1.51871038
24MP0002735_abnormal_chemical_nociception1.47418330
25MP0001542_abnormal_bone_strength1.46942155
26MP0006054_spinal_hemorrhage1.45982834
27MP0002168_other_aberrant_phenotype1.39806391
28MP0005171_absent_coat_pigmentation1.37236778
29MP0004147_increased_porphyrin_level1.34042859
30MP0001661_extended_life_span1.31104621
31MP0003566_abnormal_cell_adhesion1.28478247
32MP0003941_abnormal_skin_development1.25983674
33MP0002115_abnormal_skeleton_extremities1.25234018
34MP0010368_abnormal_lymphatic_system1.23803851
35MP0003283_abnormal_digestive_organ1.23455078
36MP0001348_abnormal_lacrimal_gland1.20276848
37MP0000013_abnormal_adipose_tissue1.16993339
38MP0000733_abnormal_muscle_development1.16845092
39MP0002837_dystrophic_cardiac_calcinosis1.11376422
40MP0008775_abnormal_heart_ventricle1.10254590
41MP0000538_abnormal_urinary_bladder1.08610583
42MP0000428_abnormal_craniofacial_morphol1.07429624
43MP0003385_abnormal_body_wall1.07356765
44MP0010030_abnormal_orbit_morphology1.06967948
45MP0000534_abnormal_ureter_morphology1.04865433
46MP0003091_abnormal_cell_migration1.04850995
47MP0002998_abnormal_bone_remodeling1.04208016
48MP0004233_abnormal_muscle_weight1.03921140
49MP0003942_abnormal_urinary_system1.02721142
50MP0000749_muscle_degeneration1.01456175
51MP0001243_abnormal_dermal_layer1.00216606
52MP0002972_abnormal_cardiac_muscle0.99808106
53MP0005187_abnormal_penis_morphology0.99789302
54MP0004036_abnormal_muscle_relaxation0.99773077
55MP0000163_abnormal_cartilage_morphology0.98444014
56MP0000750_abnormal_muscle_regeneration0.96831628
57MP0004134_abnormal_chest_morphology0.95496453
58MP0003300_gastrointestinal_ulcer0.91903109
59MP0002282_abnormal_trachea_morphology0.89928093
60MP0002736_abnormal_nociception_after0.88390743
61MP0000639_abnormal_adrenal_gland0.88081761
62MP0000049_abnormal_middle_ear0.87671497
63MP0002909_abnormal_adrenal_gland0.87515148
64MP0003191_abnormal_cellular_cholesterol0.87398147
65MP0001849_ear_inflammation0.86898453
66MP0005385_cardiovascular_system_phenoty0.86725370
67MP0001544_abnormal_cardiovascular_syste0.86725370
68MP0002113_abnormal_skeleton_development0.85531842
69MP0004883_abnormal_blood_vessel0.84740945
70MP0004087_abnormal_muscle_fiber0.84414452
71MP0002877_abnormal_melanocyte_morpholog0.84045729
72MP0005620_abnormal_muscle_contractility0.83768025
73MP0003252_abnormal_bile_duct0.83214864
74MP0004215_abnormal_myocardial_fiber0.83176560
75MP0010386_abnormal_urinary_bladder0.80763018
76MP0005369_muscle_phenotype0.80462056
77MP0006138_congestive_heart_failure0.79418343
78MP0001879_abnormal_lymphatic_vessel0.79249154
79MP0004130_abnormal_muscle_cell0.79191427
80MP0009780_abnormal_chondrocyte_physiolo0.78969759
81MP0005390_skeleton_phenotype0.78301856
82MP0005595_abnormal_vascular_smooth0.77456652
83MP0000759_abnormal_skeletal_muscle0.76619596
84MP0002933_joint_inflammation0.75012719
85MP0002128_abnormal_blood_circulation0.74903227
86MP0002109_abnormal_limb_morphology0.74751034
87MP0000343_altered_response_to0.74082579
88MP0002932_abnormal_joint_morphology0.73697039
89MP0000767_abnormal_smooth_muscle0.73335458
90MP0003795_abnormal_bone_structure0.72821363
91MP0005165_increased_susceptibility_to0.71505609
92MP0000747_muscle_weakness0.71130811
93MP0005164_abnormal_response_to0.71033394
94MP0002269_muscular_atrophy0.70947936
95MP0010352_gastrointestinal_tract_polyps0.69094978
96MP0003315_abnormal_perineum_morphology0.68903753
97MP0004484_altered_response_of0.68472741
98MP0009053_abnormal_anal_canal0.67419864
99MP0003045_fibrosis0.67374801
100MP0005388_respiratory_system_phenotype0.67058729
101MP0002133_abnormal_respiratory_system0.67058729
102MP0005197_abnormal_uvea_morphology0.65627677
103MP0003755_abnormal_palate_morphology0.65322499
104MP0008004_abnormal_stomach_pH0.65164025
105MP0000432_abnormal_head_morphology0.62752888
106MP0003115_abnormal_respiratory_system0.62572189
107MP0001270_distended_abdomen0.62518153
108MP0000762_abnormal_tongue_morphology0.62404190
109MP0010630_abnormal_cardiac_muscle0.61701424
110MP0010771_integument_phenotype0.61614408
111MP0001614_abnormal_blood_vessel0.59184236
112MP0000003_abnormal_adipose_tissue0.57401132
113MP0005360_urolithiasis0.56931399
114MP0000681_abnormal_thyroid_gland0.56276699
115MP0001915_intracranial_hemorrhage0.54068498
116MP0002114_abnormal_axial_skeleton0.53433965
117MP0003448_altered_tumor_morphology0.53232047
118MP0001175_abnormal_lung_morphology0.52724247
119MP0001533_abnormal_skeleton_physiology0.52623437
120MP0002116_abnormal_craniofacial_bone0.52311026
121MP0000604_amyloidosis0.50927228
122MP0002249_abnormal_larynx_morphology0.50049113
123MP0000462_abnormal_digestive_system0.49934527
124MP0002796_impaired_skin_barrier0.48487869
125MP0000467_abnormal_esophagus_morphology0.47793564
126MP0003828_pulmonary_edema0.46142185
127MP0005193_abnormal_anterior_eye0.46039407

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.59789266
2Premature rupture of membranes (HP:0001788)7.10840830
3Ankle contracture (HP:0006466)5.35208330
4Broad metatarsal (HP:0001783)5.08519380
5Follicular hyperkeratosis (HP:0007502)5.02426287
6Aortic dissection (HP:0002647)4.78631652
7Soft skin (HP:0000977)4.77187455
8Peritonitis (HP:0002586)4.16344882
9Fragile skin (HP:0001030)4.15989168
10Aortic aneurysm (HP:0004942)4.07089709
11Atrophic scars (HP:0001075)4.02895284
12Type 1 muscle fiber predominance (HP:0003803)3.95463972
13Shallow orbits (HP:0000586)3.89899841
14Gonadotropin excess (HP:0000837)3.79997785
15Abnormality of dentin (HP:0010299)3.71698708
16Bladder diverticulum (HP:0000015)3.69626463
17Neonatal short-limb short stature (HP:0008921)3.53407172
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.41454329
19Dilatation of the ascending aorta (HP:0005111)3.21781459
20Enlarged penis (HP:0000040)3.20231470
21Cerebral aneurysm (HP:0004944)3.19969636
22Slender build (HP:0001533)3.17550914
23Cervical subluxation (HP:0003308)3.14432972
24Increased connective tissue (HP:0009025)3.11265411
25Wormian bones (HP:0002645)3.09085997
26Genu recurvatum (HP:0002816)3.04459096
27Spinal rigidity (HP:0003306)3.01910900
28Biconcave vertebral bodies (HP:0004586)3.00883965
29Blue sclerae (HP:0000592)3.00145862
30Abnormal respiratory motile cilium physiology (HP:0012261)2.92222043
31Abnormal ciliary motility (HP:0012262)2.92035465
32Vertebral compression fractures (HP:0002953)2.91532009
33Increased variability in muscle fiber diameter (HP:0003557)2.89688437
34Hyperextensible skin (HP:0000974)2.87518670
35Abnormal respiratory epithelium morphology (HP:0012253)2.87466810
36Abnormal respiratory motile cilium morphology (HP:0005938)2.87466810
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.81137056
38Absent/shortened dynein arms (HP:0200106)2.81137056
39Rhinitis (HP:0012384)2.80482801
40Absent frontal sinuses (HP:0002688)2.78722818
41Mildly elevated creatine phosphokinase (HP:0008180)2.78501343
42Infantile muscular hypotonia (HP:0008947)2.77523257
43Mitral valve prolapse (HP:0001634)2.75961359
44Wide anterior fontanel (HP:0000260)2.68380472
45Bowel diverticulosis (HP:0005222)2.66063490
46Aortic regurgitation (HP:0001659)2.52249024
47Wrist flexion contracture (HP:0001239)2.50518610
48Hypoventilation (HP:0002791)2.44898691
49Abnormality of skeletal muscle fiber size (HP:0012084)2.42817015
50Knee flexion contracture (HP:0006380)2.41487469
51Ulnar claw (HP:0001178)2.39601563
52Bell-shaped thorax (HP:0001591)2.38458371
53Elbow flexion contracture (HP:0002987)2.37852654
54Mitral stenosis (HP:0001718)2.36341945
55Abnormality of the acetabulum (HP:0003170)2.35740495
56Overgrowth (HP:0001548)2.34088614
57Ulnar deviation of the wrist (HP:0003049)2.33072457
58Coronal craniosynostosis (HP:0004440)2.32988629
59Short nail (HP:0001799)2.30747248
60Cardiovascular calcification (HP:0011915)2.28582948
61Joint stiffness (HP:0001387)2.26735073
62Aplasia involving bones of the upper limbs (HP:0009823)2.26454022
63Aplasia of the phalanges of the hand (HP:0009802)2.26454022
64Aplasia involving bones of the extremities (HP:0009825)2.26454022
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.24827824
66Osteolytic defects of the hand bones (HP:0009699)2.24827824
67Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.24140521
68Osteoarthritis (HP:0002758)2.24094228
69Round ear (HP:0100830)2.24081539
70Venous insufficiency (HP:0005293)2.23591327
71Abnormality of the nasal mucosa (HP:0000433)2.22766771
72Aortic valve stenosis (HP:0001650)2.21234672
73Ovoid vertebral bodies (HP:0003300)2.18391021
74Aneurysm (HP:0002617)2.18260720
75Buphthalmos (HP:0000557)2.17185360
76Mild short stature (HP:0003502)2.16269291
77Breech presentation (HP:0001623)2.15626205
78Nasal polyposis (HP:0100582)2.15097399
79Abnormal delivery (HP:0001787)2.14053980
80Venous abnormality (HP:0002624)2.13954348
81Ectopia lentis (HP:0001083)2.13695187
82Femoral bowing (HP:0002980)2.11250229
83Vascular tortuosity (HP:0004948)2.10857052
84Lymphangioma (HP:0100764)2.10701917
85Joint laxity (HP:0001388)2.09834880
86Broad ribs (HP:0000885)2.09328861
87Thin bony cortex (HP:0002753)2.09140012
88Mitral regurgitation (HP:0001653)2.08448712
89Hyporeflexia of lower limbs (HP:0002600)2.06289638
90Cupped ribs (HP:0000887)2.04121757
91Arterial tortuosity (HP:0005116)2.00097014
92Mesomelia (HP:0003027)1.99770678
93Generalized amyotrophy (HP:0003700)1.98551424
94Natal tooth (HP:0000695)1.97556252
95Nuclear cataract (HP:0100018)1.96385855
96Spinal cord compression (HP:0002176)1.95769146
97Deviation of the hallux (HP:0010051)1.94291910
98Thoracolumbar scoliosis (HP:0002944)1.93763293
99Camptodactyly of toe (HP:0001836)1.93604443
100Narrow nasal bridge (HP:0000446)1.92466977
101Action tremor (HP:0002345)1.91414687
102Tibial bowing (HP:0002982)1.90845318
103Turricephaly (HP:0000262)1.90302867
104Delayed closure of the anterior fontanelle (HP:0001476)1.90161718
105Renal salt wasting (HP:0000127)1.89651241
106Alopecia of scalp (HP:0002293)1.88505495
107Atelectasis (HP:0100750)1.88503564
108Hammertoe (HP:0001765)1.87128802
109Delayed cranial suture closure (HP:0000270)1.85874701
110Short hallux (HP:0010109)1.84677992
111Striae distensae (HP:0001065)1.83413532
112Abnormality of the ischium (HP:0003174)1.82891643
113Abnormality of the peritoneum (HP:0002585)1.82771818
114Broad long bones (HP:0005622)1.82706773
115Ulnar bowing (HP:0003031)1.82530504
116Limb-girdle muscle weakness (HP:0003325)1.82402733
117Lower limb amyotrophy (HP:0007210)1.82380260
118Hypoplasia of the odontoid process (HP:0003311)1.82099563
119Limited hip movement (HP:0008800)1.81494994
120Osteopenia (HP:0000938)1.80919969
121Hallux valgus (HP:0001822)1.77425717
122Flared iliac wings (HP:0002869)1.77197066
123Aplasia/Hypoplasia of the hallux (HP:0008362)1.76545486
124Abnormality of the frontal sinuses (HP:0002687)1.75843968
125Menstrual irregularities (HP:0000858)1.75810449
126Redundant skin (HP:0001582)1.75591806
127Abnormality of skull ossification (HP:0002703)1.73541253
128Delayed gross motor development (HP:0002194)1.73497020
129Inguinal hernia (HP:0000023)1.72852289
130Coxa vara (HP:0002812)1.72772184
131Abnormality of carpal bone ossification (HP:0006257)1.70844337
132Spinal cord lesions (HP:0100561)1.70637898
133Syringomyelia (HP:0003396)1.70637898
134Metaphyseal cupping (HP:0003021)1.70436375
135Thin skin (HP:0000963)1.69636975
136Spondylolisthesis (HP:0003302)1.69440659
137Hypoplasia of the iris (HP:0007676)1.68255630
138Protruding ear (HP:0000411)1.68197702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.46393185
2WNK43.30922632
3LATS23.17061127
4LMTK23.13192238
5PDGFRA3.08091586
6EPHA33.03649693
7FRK2.86634556
8AKT32.83818177
9TTN2.48683064
10TESK12.40583992
11SIK12.40422069
12EEF2K2.29051005
13MAPK152.26574513
14NEK92.22413903
15FER2.21571511
16PKN22.19151489
17NTRK32.18365964
18STK392.17120207
19PIK3CA2.09425205
20MAP3K62.03873319
21FGFR22.02586110
22PRKD21.98245660
23WNK11.81730757
24STK38L1.79049146
25TRIB31.76423883
26PRKD31.73561411
27MYLK1.69156786
28CASK1.68167518
29MINK11.64713429
30SCYL21.54783960
31PAK31.53491371
32PDK31.46861715
33PDK41.46861715
34FLT31.45620693
35FGFR11.43117196
36KIT1.39306228
37EPHA21.34708785
38MAP3K31.33949630
39PAK41.33848494
40RET1.31565897
41ROCK11.30604854
42PHKG11.27888579
43PHKG21.27888579
44LATS11.26883966
45ICK1.24953661
46OXSR11.24881755
47TGFBR21.22052808
48TRPM71.21486088
49EPHB11.14776039
50NTRK11.12345066
51PDK21.09321051
52MAP2K11.07961459
53GRK11.07497134
54MAPK71.06510936
55PDGFRB1.04468747
56FGFR31.04453869
57LIMK11.01797989
58EPHB20.98862571
59MET0.97951354
60CAMKK20.94858789
61JAK10.94688944
62PBK0.93531708
63PLK20.90216653
64GRK50.89314302
65MAPKAPK30.88085412
66NEK10.87883802
67ADRBK10.85058659
68PTK20.84130397
69PIK3CG0.84124722
70STK30.83271347
71KSR20.81196661
72STK240.80561709
73PRKCH0.78961513
74FGFR40.78876192
75PAK20.77410249
76BMX0.77097972
77RIPK10.72881142
78ILK0.72381761
79MELK0.70009343
80BRSK20.68694275
81IRAK30.67520263
82LRRK20.65931067
83ERBB40.65658089
84SMG10.64939300
85PTK2B0.64532924
86MAP3K20.62600253
87PRKCE0.62123819
88ROCK20.61776639
89PIM20.57885932
90PAK60.57411410
91DMPK0.56763917
92SGK30.56068580
93ARAF0.55590820
94MST1R0.53962108
95PRKD10.52492406
96SGK20.52356624
97TYK20.52219767
98SGK4940.50359558
99SGK2230.50359558
100INSR0.50292247
101BCR0.49895440
102WNK30.49351992
103ADRBK20.49047691
104IGF1R0.48445266
105ERN10.47445869
106PRKCG0.47226773
107CAMK1G0.47067393
108ABL20.46008681
109CDC42BPA0.45646262
110ERBB30.45303601
111TBK10.43855143
112STK380.43582360
113GRK70.42273874
114MOS0.41878645
115TGFBR10.41752499
116EIF2AK20.41699379
117MAP2K40.41418264
118MARK20.41249776
119CAMKK10.39442743
120PDPK10.38708910
121MUSK0.37772524
122MAPK120.37075368
123MAP3K70.36757282
124PRKG20.35864824
125GSK3A0.35776067
126ABL10.34137613
127CAMK1D0.33673360
128MAP2K30.33632748
129MTOR0.32896597
130MAPK110.32812615
131PRKACB0.30325271
132HIPK20.29365825
133CSF1R0.28594218
134CDK80.28420876
135PAK10.28231753
136CAMK2G0.27738099
137CDK60.27707328
138PRKAA20.27233161
139RPS6KA20.26242475
140SRC0.25238728
141PDK10.25077828

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.57739900
2Ovarian steroidogenesis_Homo sapiens_hsa049133.28173458
3Protein digestion and absorption_Homo sapiens_hsa049742.39555945
4Focal adhesion_Homo sapiens_hsa045102.31846158
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.17564415
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04612301
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.98637116
8Steroid hormone biosynthesis_Homo sapiens_hsa001401.90984007
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83008137
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80111699
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78479353
12Propanoate metabolism_Homo sapiens_hsa006401.76098531
13Dilated cardiomyopathy_Homo sapiens_hsa054141.69940284
14Fatty acid degradation_Homo sapiens_hsa000711.69840988
15Melanoma_Homo sapiens_hsa052181.68378997
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.65305562
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65151412
18Malaria_Homo sapiens_hsa051441.62986548
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.56893882
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55720463
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55347235
22Complement and coagulation cascades_Homo sapiens_hsa046101.51669917
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.50348999
24Histidine metabolism_Homo sapiens_hsa003401.45815657
25Fatty acid metabolism_Homo sapiens_hsa012121.44321276
26Proteoglycans in cancer_Homo sapiens_hsa052051.43685239
27Chemical carcinogenesis_Homo sapiens_hsa052041.42940111
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.40932767
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40336789
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37743621
31Pyruvate metabolism_Homo sapiens_hsa006201.35968640
32Amoebiasis_Homo sapiens_hsa051461.34006884
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28841074
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27073508
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26404092
36Phenylalanine metabolism_Homo sapiens_hsa003601.21298106
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21042229
38Hedgehog signaling pathway_Homo sapiens_hsa043401.20275355
39Tyrosine metabolism_Homo sapiens_hsa003501.13871494
40PPAR signaling pathway_Homo sapiens_hsa033201.13770003
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12967622
42Glioma_Homo sapiens_hsa052141.09944650
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08837669
44Starch and sucrose metabolism_Homo sapiens_hsa005001.05948550
45TGF-beta signaling pathway_Homo sapiens_hsa043501.05681279
46Sphingolipid metabolism_Homo sapiens_hsa006001.05156130
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99353466
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99326137
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98075940
50Butanoate metabolism_Homo sapiens_hsa006500.94429735
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94419249
52Adherens junction_Homo sapiens_hsa045200.92437904
53Prion diseases_Homo sapiens_hsa050200.90812917
54Wnt signaling pathway_Homo sapiens_hsa043100.88525684
55Gap junction_Homo sapiens_hsa045400.85972553
56Phagosome_Homo sapiens_hsa041450.84546927
57Retinol metabolism_Homo sapiens_hsa008300.84291577
58Insulin signaling pathway_Homo sapiens_hsa049100.83368077
59Insulin resistance_Homo sapiens_hsa049310.82698577
60Other glycan degradation_Homo sapiens_hsa005110.82617572
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.82236266
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81653666
63Hippo signaling pathway_Homo sapiens_hsa043900.80986089
64Glutathione metabolism_Homo sapiens_hsa004800.80807098
65Mineral absorption_Homo sapiens_hsa049780.80595672
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79772475
67Thyroid hormone synthesis_Homo sapiens_hsa049180.77657051
68Lysosome_Homo sapiens_hsa041420.76478769
69Cardiac muscle contraction_Homo sapiens_hsa042600.75045976
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74937094
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73806553
72Pertussis_Homo sapiens_hsa051330.73195095
73Rap1 signaling pathway_Homo sapiens_hsa040150.72719233
74Basal cell carcinoma_Homo sapiens_hsa052170.72011792
75Carbon metabolism_Homo sapiens_hsa012000.71826086
76Gastric acid secretion_Homo sapiens_hsa049710.71310229
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.71216576
78Choline metabolism in cancer_Homo sapiens_hsa052310.70475892
79Circadian rhythm_Homo sapiens_hsa047100.68930007
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68762793
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68326937
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.66810293
83Endocytosis_Homo sapiens_hsa041440.66629867
84Prostate cancer_Homo sapiens_hsa052150.65736110
85Tryptophan metabolism_Homo sapiens_hsa003800.65510778
86* Phospholipase D signaling pathway_Homo sapiens_hsa040720.65469323
87Prolactin signaling pathway_Homo sapiens_hsa049170.65220496
88Platelet activation_Homo sapiens_hsa046110.64356373
89Glucagon signaling pathway_Homo sapiens_hsa049220.63800176
90MicroRNAs in cancer_Homo sapiens_hsa052060.63515163
91Fatty acid biosynthesis_Homo sapiens_hsa000610.63426008
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62005277
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60893539
94Sulfur metabolism_Homo sapiens_hsa009200.60456842
95HIF-1 signaling pathway_Homo sapiens_hsa040660.60456695
96mTOR signaling pathway_Homo sapiens_hsa041500.60423984
97Chronic myeloid leukemia_Homo sapiens_hsa052200.59777834
98Axon guidance_Homo sapiens_hsa043600.58663506
99Melanogenesis_Homo sapiens_hsa049160.58617677
100Arachidonic acid metabolism_Homo sapiens_hsa005900.58292104
101Ras signaling pathway_Homo sapiens_hsa040140.56320136
102Renin secretion_Homo sapiens_hsa049240.54986383
103Estrogen signaling pathway_Homo sapiens_hsa049150.54976249
104Hepatitis C_Homo sapiens_hsa051600.54253418
105Bile secretion_Homo sapiens_hsa049760.53841652
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53378045
107N-Glycan biosynthesis_Homo sapiens_hsa005100.53284968
108Small cell lung cancer_Homo sapiens_hsa052220.52619686
109Tight junction_Homo sapiens_hsa045300.52613980
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52428714
111Bladder cancer_Homo sapiens_hsa052190.51742840
112Peroxisome_Homo sapiens_hsa041460.50437282
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50331499
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50127469
115TNF signaling pathway_Homo sapiens_hsa046680.49772716
116GnRH signaling pathway_Homo sapiens_hsa049120.49376073
117ABC transporters_Homo sapiens_hsa020100.49093410
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49055854
119Pathways in cancer_Homo sapiens_hsa052000.48770149
120beta-Alanine metabolism_Homo sapiens_hsa004100.48004248
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46557079
122Endometrial cancer_Homo sapiens_hsa052130.46102513
123AMPK signaling pathway_Homo sapiens_hsa041520.45688322
124Pancreatic cancer_Homo sapiens_hsa052120.45395202
125Olfactory transduction_Homo sapiens_hsa047400.44582820
126ErbB signaling pathway_Homo sapiens_hsa040120.44555512
127Oxytocin signaling pathway_Homo sapiens_hsa049210.43929382
128Arginine and proline metabolism_Homo sapiens_hsa003300.43585334
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.42513931
130Renin-angiotensin system_Homo sapiens_hsa046140.41810153
131Type II diabetes mellitus_Homo sapiens_hsa049300.41126341
132Lysine degradation_Homo sapiens_hsa003100.40903797
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.40535015
134Caffeine metabolism_Homo sapiens_hsa002320.39899775
135Cocaine addiction_Homo sapiens_hsa050300.39890270
136Vitamin B6 metabolism_Homo sapiens_hsa007500.39812354
137Vibrio cholerae infection_Homo sapiens_hsa051100.38969849
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37978837

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