PTGFRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of keratinocyte proliferation (GO:0010839)4.94149180
2hemidesmosome assembly (GO:0031581)4.90838211
3protein heterotrimerization (GO:0070208)4.54928440
4polarized epithelial cell differentiation (GO:0030859)4.03949256
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.00682330
6regulation of keratinocyte proliferation (GO:0010837)3.98927741
7hippo signaling (GO:0035329)3.94918510
8collagen fibril organization (GO:0030199)3.93339488
9epithelial cell-cell adhesion (GO:0090136)3.88492182
10establishment of apical/basal cell polarity (GO:0035089)3.83262570
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.79144812
12endodermal cell differentiation (GO:0035987)3.72417672
13regulation of hippo signaling (GO:0035330)3.60132345
14gap junction assembly (GO:0016264)3.57098618
15bone trabecula formation (GO:0060346)3.56977327
16paraxial mesoderm development (GO:0048339)3.51834706
17plasma membrane repair (GO:0001778)3.49187043
18cell-substrate junction assembly (GO:0007044)3.44984254
19basement membrane organization (GO:0071711)3.37914263
20negative regulation of chondrocyte differentiation (GO:0032331)3.36687540
21chondrocyte proliferation (GO:0035988)3.31956056
22establishment of monopolar cell polarity (GO:0061162)3.28503712
23establishment or maintenance of monopolar cell polarity (GO:0061339)3.28503712
24regulation of transforming growth factor beta2 production (GO:0032909)3.27660075
25keratinocyte proliferation (GO:0043616)3.27117745
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.24691054
27axon extension involved in axon guidance (GO:0048846)3.20876185
28neuron projection extension involved in neuron projection guidance (GO:1902284)3.20876185
29dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.19117382
30negative regulation of catenin import into nucleus (GO:0035414)3.14200135
31cytoskeletal anchoring at plasma membrane (GO:0007016)3.13801021
32skin morphogenesis (GO:0043589)3.13459220
33negative regulation of fatty acid transport (GO:2000192)3.11292103
34collagen metabolic process (GO:0032963)3.07039504
35branching involved in salivary gland morphogenesis (GO:0060445)3.07033701
36adherens junction assembly (GO:0034333)3.06907013
37regulation of SMAD protein import into nucleus (GO:0060390)3.06570292
38artery development (GO:0060840)3.05980703
39regulation of water loss via skin (GO:0033561)3.05690666
40cell adhesion mediated by integrin (GO:0033627)3.03136179
41cardiac right ventricle morphogenesis (GO:0003215)3.02154506
42endocardial cushion development (GO:0003197)3.00776301
43desmosome organization (GO:0002934)3.00640478
44establishment of tissue polarity (GO:0007164)3.00465560
45establishment of planar polarity (GO:0001736)3.00465560
46renal filtration (GO:0097205)2.99382761
47cardiac myofibril assembly (GO:0055003)2.99339366
48multicellular organismal macromolecule metabolic process (GO:0044259)2.98503564
49regulation of cardioblast differentiation (GO:0051890)2.96723166
50limb bud formation (GO:0060174)2.96180356
51collagen catabolic process (GO:0030574)2.96113425
52positive regulation of SMAD protein import into nucleus (GO:0060391)2.94192198
53lateral sprouting from an epithelium (GO:0060601)2.90339983
54establishment of skin barrier (GO:0061436)2.89321020
55negative regulation of cartilage development (GO:0061037)2.86517844
56extracellular matrix disassembly (GO:0022617)2.86428013
57insulin-like growth factor receptor signaling pathway (GO:0048009)2.86050922
58mesodermal cell differentiation (GO:0048333)2.83777815
59multicellular organismal catabolic process (GO:0044243)2.83283374
60bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82338932
61apoptotic cell clearance (GO:0043277)2.82217740
62cell migration involved in sprouting angiogenesis (GO:0002042)2.82182930
63multicellular organismal metabolic process (GO:0044236)2.80470346
64embryonic foregut morphogenesis (GO:0048617)2.80074759
65lung-associated mesenchyme development (GO:0060484)2.78999713
66regulation of tight junction assembly (GO:2000810)2.78703929
67ectoderm development (GO:0007398)2.77779943
68sequestering of extracellular ligand from receptor (GO:0035581)2.75896146
69anatomical structure regression (GO:0060033)2.73684787
70negative regulation of axon guidance (GO:1902668)2.72993081
71cell migration involved in heart development (GO:0060973)2.71495073
72stress fiber assembly (GO:0043149)2.71378535
73apical protein localization (GO:0045176)2.71015725
74regulation of heart morphogenesis (GO:2000826)2.69881048
75negative regulation of axon extension involved in axon guidance (GO:0048843)2.69201514
76glomerular basement membrane development (GO:0032836)2.68831717
77Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.68768725
78regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.68378643
79establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.68324879
80positive regulation of endothelial cell apoptotic process (GO:2000353)2.67406079
81regulation of chondrocyte differentiation (GO:0032330)2.66910304
82vascular endothelial growth factor signaling pathway (GO:0038084)2.66743201
83negative regulation of cell fate specification (GO:0009996)2.66724939
84organ induction (GO:0001759)2.66272922
85neural crest cell development (GO:0014032)2.65117743
86gastrulation with mouth forming second (GO:0001702)2.64834028
87outer ear morphogenesis (GO:0042473)2.63737819
88mammary gland development (GO:0030879)2.63519013
89heart valve morphogenesis (GO:0003179)2.62938479
90craniofacial suture morphogenesis (GO:0097094)2.62900048
91positive regulation of mesenchymal cell proliferation (GO:0002053)2.61433397
92regulation of establishment of planar polarity (GO:0090175)2.61394305
93notochord development (GO:0030903)2.61345371
94fibroblast migration (GO:0010761)2.61059322
95ventricular cardiac muscle cell development (GO:0055015)2.59018881
96embryonic camera-type eye development (GO:0031076)2.58874483
97wound healing, spreading of epidermal cells (GO:0035313)2.58479886
98positive regulation of epithelial to mesenchymal transition (GO:0010718)2.58353882
99endothelial cell morphogenesis (GO:0001886)2.58275419
100retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57785592
101non-canonical Wnt signaling pathway (GO:0035567)2.57171852
102protein localization to cell surface (GO:0034394)2.56160341
103regulation of axon guidance (GO:1902667)2.55499220
104dorsal/ventral axis specification (GO:0009950)2.55076492
105renal system development (GO:0072001)2.55029138
106embryonic skeletal joint morphogenesis (GO:0060272)2.54673045
107keratinocyte development (GO:0003334)2.53913288
108regulation of catenin import into nucleus (GO:0035412)2.53867035
109regulation of cell fate specification (GO:0042659)2.53584154
110cell-substrate adherens junction assembly (GO:0007045)2.53352476
111focal adhesion assembly (GO:0048041)2.53352476
112atrioventricular valve morphogenesis (GO:0003181)2.52721572
113mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.52574589
114negative regulation of epidermis development (GO:0045683)2.52386741
115heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.52297322
116asymmetric protein localization (GO:0008105)2.52182544
117substrate adhesion-dependent cell spreading (GO:0034446)2.51706560
118epidermis development (GO:0008544)2.51130909
119regulation of axon extension involved in axon guidance (GO:0048841)2.50891765
120chondrocyte development (GO:0002063)2.50580488
121glomerular filtration (GO:0003094)2.49194662
122surfactant homeostasis (GO:0043129)2.48771009
123heparan sulfate proteoglycan metabolic process (GO:0030201)2.48429430
124cell surface receptor signaling pathway involved in heart development (GO:0061311)2.48014823
125embryonic cranial skeleton morphogenesis (GO:0048701)2.47810169
126mesenchyme development (GO:0060485)2.47629189
127intestinal epithelial cell development (GO:0060576)2.46947230
128keratan sulfate catabolic process (GO:0042340)2.46474001
129regulation of posttranscriptional gene silencing (GO:0060147)2.46290292
130regulation of gene silencing by miRNA (GO:0060964)2.46290292
131regulation of gene silencing by RNA (GO:0060966)2.46290292
132apoptotic process involved in morphogenesis (GO:0060561)2.46072189
133ganglion development (GO:0061548)2.45876746
134epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45850018
135negative regulation of heart growth (GO:0061117)2.45760199
136negative regulation of cardiac muscle tissue growth (GO:0055022)2.45760199
137COPI coating of Golgi vesicle (GO:0048205)2.44807679
138Golgi transport vesicle coating (GO:0048200)2.44807679
139Notch signaling involved in heart development (GO:0061314)2.44762609
140regulation of hair follicle development (GO:0051797)2.44507590
141adherens junction organization (GO:0034332)2.42995554
142negative chemotaxis (GO:0050919)2.42479955
143midgut development (GO:0007494)2.41516887
144cell junction assembly (GO:0034329)2.38692182
145endocardial cushion morphogenesis (GO:0003203)2.37730890
146negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.37575869
147morphogenesis of an epithelial sheet (GO:0002011)2.35152301
148atrial septum morphogenesis (GO:0060413)2.34450515
149cell communication involved in cardiac conduction (GO:0086065)2.31621880
150mesenchyme morphogenesis (GO:0072132)2.31120870
151lung lobe morphogenesis (GO:0060463)2.29471854
152mesenchymal cell development (GO:0014031)2.28747249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.44003277
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.10697725
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.18818073
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.08899436
5CLOCK_20551151_ChIP-Seq_293T_Human2.65088643
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.54042072
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44506479
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.36431278
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30564779
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.23256316
11ZNF263_19887448_ChIP-Seq_K562_Human2.18227250
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.17294198
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.14126943
14* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.12543282
15ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.09833707
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.03949103
17* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.02526439
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99646822
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97418435
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.95156056
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.94395405
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93465623
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.89824152
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.85976704
25* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85736348
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.77525238
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.72714636
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70667850
29* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69976809
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69266293
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68520793
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68520793
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68520793
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67285238
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66969646
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64760801
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.64197399
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.63490082
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63228182
40* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62953349
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60600473
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60002882
43* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59640217
44* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59640217
45* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58918512
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58881686
47* TP53_18474530_ChIP-ChIP_U2OS_Human1.58232183
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57656190
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57532411
50ATF3_27146783_Chip-Seq_COLON_Human1.57041176
51CJUN_26792858_Chip-Seq_BT549_Human1.55679099
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.54761644
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.53646377
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.52865159
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51540009
56BRD4_25478319_ChIP-Seq_HGPS_Human1.51102052
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50930388
58* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50090159
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.46309268
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45925233
61KDM2B_26808549_Chip-Seq_K562_Human1.45618167
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44608734
63E2F7_22180533_ChIP-Seq_HELA_Human1.44282784
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44252747
65* ISL1_27105846_Chip-Seq_CPCs_Mouse1.43043484
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.40456645
67KDM2B_26808549_Chip-Seq_DND41_Human1.39872074
68* TBX20_22328084_ChIP-Seq_HEART_Mouse1.37748187
69* TBX20_22080862_ChIP-Seq_HEART_Mouse1.37748187
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.36714988
71* UBF1/2_26484160_Chip-Seq_HMECs_Human1.35170551
72CDX2_20551321_ChIP-Seq_CACO-2_Human1.34763272
73* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34660279
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33084060
75* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30136425
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28302714
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27958209
78* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27598033
79* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26267716
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.24745186
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24694229
82KLF5_25053715_ChIP-Seq_YYC3_Human1.22199359
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21652839
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21150091
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21150091
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.19470395
87* TP63_23658742_ChIP-Seq_EP156T_Human1.19000666
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18509116
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.18235992
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17884262
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16303923
92* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15808019
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14950651
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14192836
95TP53_22127205_ChIP-Seq_IMR90_Human1.13423743
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12998792
97AR_21909140_ChIP-Seq_LNCAP_Human1.12847695
98* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12746735
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.12688960
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12640692
101* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11343227
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11144911
103* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10547608
104SOX2_20726797_ChIP-Seq_SW620_Human1.09625593
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09360869
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09179005
107LXR_22292898_ChIP-Seq_THP-1_Human1.09029261
108SMAD3_21741376_ChIP-Seq_HESCs_Human1.08394026
109* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07786158
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07741854
111ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06548445
112TCF7_22412390_ChIP-Seq_EML_Mouse1.05012623
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02946326
114TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02665460
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02359788
116* GATA6_25053715_ChIP-Seq_YYC3_Human1.01958364
117* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01946260
118SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01790014
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01306918
120CREB1_26743006_Chip-Seq_LNCaP_Human1.01166484
121PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01005619
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00939016
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00880785
124* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00772403
125GBX2_23144817_ChIP-Seq_PC3_Human1.00626860
126SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98771533
127AHR_22903824_ChIP-Seq_MCF-7_Human0.98587436
128SMAD4_21799915_ChIP-Seq_A2780_Human0.98261079
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.95085093
130* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94832582
131EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94439311
132RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94439311
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90756917
134* TP53_16413492_ChIP-PET_HCT116_Human0.90109136
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90077417
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.90068634
137* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89224656
138MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88658327
139ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87009070
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86866987
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86447625
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86109284
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84638523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.16794987
2MP0005275_abnormal_skin_tensile4.22715050
3MP0003705_abnormal_hypodermis_morpholog4.09683379
4MP0005503_abnormal_tendon_morphology2.97011233
5MP0004272_abnormal_basement_membrane2.91835232
6MP0010030_abnormal_orbit_morphology2.58323201
7MP0001958_emphysema2.52515488
8MP0000537_abnormal_urethra_morphology2.48093205
9MP0005623_abnormal_meninges_morphology2.43380537
10MP0010352_gastrointestinal_tract_polyps2.32101927
11MP0010234_abnormal_vibrissa_follicle2.24696530
12MP0003566_abnormal_cell_adhesion2.22427322
13MP0003279_aneurysm2.01704898
14MP0009053_abnormal_anal_canal1.88626385
15MP0005076_abnormal_cell_differentiation1.86679427
16MP0000733_abnormal_muscle_development1.86118855
17MP0002060_abnormal_skin_morphology1.83504860
18MP0006054_spinal_hemorrhage1.78680660
19MP0005409_darkened_coat_color1.75826863
20MP0000751_myopathy1.72061059
21MP0003385_abnormal_body_wall1.71347853
22MP0002098_abnormal_vibrissa_morphology1.70516997
23MP0001849_ear_inflammation1.68729977
24MP0003941_abnormal_skin_development1.68121872
25MP0005508_abnormal_skeleton_morphology1.59495706
26MP0000534_abnormal_ureter_morphology1.56807260
27MP0004084_abnormal_cardiac_muscle1.52547497
28MP0005023_abnormal_wound_healing1.47268136
29MP0002877_abnormal_melanocyte_morpholog1.47217951
30MP0003115_abnormal_respiratory_system1.46825361
31MP0000762_abnormal_tongue_morphology1.43347245
32MP0003283_abnormal_digestive_organ1.42695472
33MP0009384_cardiac_valve_regurgitation1.41564374
34MP0000428_abnormal_craniofacial_morphol1.40483028
35MP0001216_abnormal_epidermal_layer1.38959818
36MP0005257_abnormal_intraocular_pressure1.37819766
37MP0002282_abnormal_trachea_morphology1.37526612
38MP0010368_abnormal_lymphatic_system1.36396476
39MP0000750_abnormal_muscle_regeneration1.36161608
40MP0002234_abnormal_pharynx_morphology1.35572640
41MP0003091_abnormal_cell_migration1.34912170
42MP0000377_abnormal_hair_follicle1.34799857
43MP0009250_abnormal_appendicular_skeleto1.30447119
44MP0000767_abnormal_smooth_muscle1.28434122
45MP0003942_abnormal_urinary_system1.27598757
46MP0005171_absent_coat_pigmentation1.25823299
47MP0002108_abnormal_muscle_morphology1.25745329
48MP0002896_abnormal_bone_mineralization1.25649502
49MP0005367_renal/urinary_system_phenotyp1.23090491
50MP0000516_abnormal_urinary_system1.23090491
51MP0003935_abnormal_craniofacial_develop1.22392950
52MP0003567_abnormal_fetal_cardiomyocyte1.21084012
53MP0002796_impaired_skin_barrier1.20785990
54MP0009780_abnormal_chondrocyte_physiolo1.20058307
55MP0002932_abnormal_joint_morphology1.18135782
56MP0003755_abnormal_palate_morphology1.15519566
57MP0004087_abnormal_muscle_fiber1.15142759
58MP0004197_abnormal_fetal_growth/weight/1.11535049
59MP0004264_abnormal_extraembryonic_tissu1.10609440
60MP0005248_abnormal_Harderian_gland1.10472062
61MP0003119_abnormal_digestive_system1.10316573
62MP0010630_abnormal_cardiac_muscle1.10182124
63MP0000467_abnormal_esophagus_morphology1.09855217
64MP0003937_abnormal_limbs/digits/tail_de1.09659302
65MP0002925_abnormal_cardiovascular_devel1.09636863
66MP0002249_abnormal_larynx_morphology1.09525770
67MP0005197_abnormal_uvea_morphology1.09344035
68MP0001299_abnormal_eye_distance/1.06456342
69MP0000538_abnormal_urinary_bladder1.06240253
70MP0000432_abnormal_head_morphology1.05597739
71MP0005408_hypopigmentation1.03310323
72MP0010678_abnormal_skin_adnexa1.02745459
73MP0000579_abnormal_nail_morphology1.02114539
74MP0004233_abnormal_muscle_weight0.99992383
75MP0003453_abnormal_keratinocyte_physiol0.98908506
76MP0006138_congestive_heart_failure0.98812441
77MP0004185_abnormal_adipocyte_glucose0.98548084
78MP0001879_abnormal_lymphatic_vessel0.96612242
79MP0000462_abnormal_digestive_system0.95395187
80MP0002084_abnormal_developmental_patter0.95279012
81MP0000427_abnormal_hair_cycle0.93895620
82MP0001243_abnormal_dermal_layer0.93518664
83MP0002233_abnormal_nose_morphology0.92433772
84MP0000049_abnormal_middle_ear0.92377877
85MP0002111_abnormal_tail_morphology0.91893846
86MP0004381_abnormal_hair_follicle0.91849027
87MP0005501_abnormal_skin_physiology0.91016768
88MP0003123_paternal_imprinting0.90592274
89MP0000163_abnormal_cartilage_morphology0.90308685
90MP0002938_white_spotting0.89612760
91MP0005330_cardiomyopathy0.89576531
92MP0002116_abnormal_craniofacial_bone0.89511143
93MP0003045_fibrosis0.89492350
94MP0002295_abnormal_pulmonary_circulatio0.89471612
95MP0002086_abnormal_extraembryonic_tissu0.89005648
96MP0000678_abnormal_parathyroid_gland0.87679755
97MP0002085_abnormal_embryonic_tissue0.87011728
98MP0008789_abnormal_olfactory_epithelium0.84453713
99MP0001614_abnormal_blood_vessel0.83980283
100MP0000566_synostosis0.83777290
101MP0002697_abnormal_eye_size0.83198043
102MP0003828_pulmonary_edema0.82148542
103MP0000383_abnormal_hair_follicle0.81632960
104MP0003300_gastrointestinal_ulcer0.81607365
105MP0002115_abnormal_skeleton_extremities0.81534977
106MP0003950_abnormal_plasma_membrane0.81154693
107MP0002128_abnormal_blood_circulation0.80609590
108MP0002088_abnormal_embryonic_growth/wei0.80149328
109MP0001175_abnormal_lung_morphology0.79637720
110MP0000627_abnormal_mammary_gland0.79066951
111MP0003984_embryonic_growth_retardation0.78990758
112MP0000266_abnormal_heart_morphology0.78841016
113MP0002109_abnormal_limb_morphology0.77623761
114MP0010771_integument_phenotype0.76453273
115MP0002092_abnormal_eye_morphology0.76374052
116MP0008932_abnormal_embryonic_tissue0.75971251
117MP0009278_abnormal_bone_marrow0.75971120
118MP0003315_abnormal_perineum_morphology0.75580943
119MP0000647_abnormal_sebaceous_gland0.75246992
120MP0005193_abnormal_anterior_eye0.73847033
121MP0001286_abnormal_eye_development0.70796785
122MP0002177_abnormal_outer_ear0.70313742
123MP0000613_abnormal_salivary_gland0.69517331
124MP0002254_reproductive_system_inflammat0.69168551
125MP0002089_abnormal_postnatal_growth/wei0.66103717
126MP0002168_other_aberrant_phenotype0.65307088

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.05372397
2Premature rupture of membranes (HP:0001788)4.80943446
3Ankle contracture (HP:0006466)4.55689705
4Shallow orbits (HP:0000586)4.32553043
5Atrophic scars (HP:0001075)4.27867366
6Abnormality of nail color (HP:0100643)4.08595929
7Plantar hyperkeratosis (HP:0007556)3.88655344
8Cerebral aneurysm (HP:0004944)3.67525288
9Increased connective tissue (HP:0009025)3.66832919
10Type 1 muscle fiber predominance (HP:0003803)3.64581867
11Broad metatarsal (HP:0001783)3.57330162
12Aortic dissection (HP:0002647)3.36162030
13Mildly elevated creatine phosphokinase (HP:0008180)3.33102883
14Thick nail (HP:0001805)3.27305761
15Fragile skin (HP:0001030)3.22071651
16Natal tooth (HP:0000695)3.00340615
17Bladder diverticulum (HP:0000015)2.97750106
18Right ventricular cardiomyopathy (HP:0011663)2.97436981
19Pili torti (HP:0003777)2.96578382
20Mitral valve prolapse (HP:0001634)2.95562083
21Spinal rigidity (HP:0003306)2.90394182
22Follicular hyperkeratosis (HP:0007502)2.87795002
23Milia (HP:0001056)2.84969168
24Short 4th metacarpal (HP:0010044)2.82202937
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.82202937
26Aortic aneurysm (HP:0004942)2.77503730
27Dilatation of the ascending aorta (HP:0005111)2.70568795
28Soft skin (HP:0000977)2.65495381
29Ridged nail (HP:0001807)2.60191723
30Palmoplantar hyperkeratosis (HP:0000972)2.57236557
31Popliteal pterygium (HP:0009756)2.55244209
32Genu recurvatum (HP:0002816)2.54532541
33Wrist flexion contracture (HP:0001239)2.51015186
34Palmar hyperkeratosis (HP:0010765)2.50142926
35Advanced eruption of teeth (HP:0006288)2.47574243
36Nail dystrophy (HP:0008404)2.46538511
37Cervical subluxation (HP:0003308)2.43919599
38Hypoplastic labia majora (HP:0000059)2.38545524
39Neonatal short-limb short stature (HP:0008921)2.37589624
40Increased variability in muscle fiber diameter (HP:0003557)2.37051345
41Abnormality of the 4th metacarpal (HP:0010012)2.35555726
42Ulnar bowing (HP:0003031)2.34221216
43Peritonitis (HP:0002586)2.29474378
44Abnormal hair laboratory examination (HP:0003328)2.28586637
45Slender build (HP:0001533)2.27418449
46Rectal prolapse (HP:0002035)2.26787764
47Hypoplasia of dental enamel (HP:0006297)2.24184375
48Microglossia (HP:0000171)2.23677995
49Subacute progressive viral hepatitis (HP:0006572)2.18530907
50Abnormality of the labia majora (HP:0012881)2.18203756
51Wormian bones (HP:0002645)2.16161791
52Aneurysm (HP:0002617)2.14624137
53Deviation of the hallux (HP:0010051)2.13744120
54Aplasia cutis congenita (HP:0001057)2.13711096
55Hyperextensible skin (HP:0000974)2.12527135
56Blue sclerae (HP:0000592)2.12422676
57Abnormality of skeletal muscle fiber size (HP:0012084)2.12397908
58Difficulty climbing stairs (HP:0003551)2.10736870
59Absent frontal sinuses (HP:0002688)2.09799740
60Muscle fiber splitting (HP:0003555)2.08565261
61Bowel diverticulosis (HP:0005222)2.08270592
62Ankyloglossia (HP:0010296)2.08252362
63Renal duplication (HP:0000075)2.07460400
64Osteolytic defects of the hand bones (HP:0009699)2.05667972
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.05667972
66Scapular winging (HP:0003691)2.04105940
67Hallux valgus (HP:0001822)2.03956280
68Short nail (HP:0001799)2.02297712
69Alopecia of scalp (HP:0002293)2.00933386
70Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.98624396
71Vertebral hypoplasia (HP:0008417)1.98624396
72Hypotrichosis (HP:0001006)1.98418125
73Coronal craniosynostosis (HP:0004440)1.96782168
74Overgrowth (HP:0001548)1.96278176
75Thin bony cortex (HP:0002753)1.96200069
76Round ear (HP:0100830)1.94590213
77Abnormality of dentin (HP:0010299)1.93251430
78Tibial bowing (HP:0002982)1.92677041
79Camptodactyly of toe (HP:0001836)1.91170636
80Buphthalmos (HP:0000557)1.87508838
81Elbow flexion contracture (HP:0002987)1.87366736
82Joint laxity (HP:0001388)1.85442035
83Selective tooth agenesis (HP:0001592)1.85228193
84Abnormality of the distal phalanx of the thumb (HP:0009617)1.85018710
85Mesomelia (HP:0003027)1.84928530
86Wide anterior fontanel (HP:0000260)1.84501205
87Vertebral arch anomaly (HP:0008438)1.84238637
88Absent eyelashes (HP:0000561)1.83080513
89Bronchomalacia (HP:0002780)1.81735295
90Flat cornea (HP:0007720)1.81356555
91Hyperacusis (HP:0010780)1.80540427
92Asymmetry of the thorax (HP:0001555)1.79827868
93Lymphangioma (HP:0100764)1.79606114
94Laryngomalacia (HP:0001601)1.79083256
95Mitral regurgitation (HP:0001653)1.77632065
96Hyporeflexia of lower limbs (HP:0002600)1.77621170
97Distal lower limb amyotrophy (HP:0008944)1.74193019
98Ventricular tachycardia (HP:0004756)1.73789804
99Striae distensae (HP:0001065)1.73686052
100Bowing of the arm (HP:0006488)1.73131270
101Bowed forearm bones (HP:0003956)1.73131270
102Abnormality of oral frenula (HP:0000190)1.72391280
103Esophageal atresia (HP:0002032)1.72354862
104Hypoplastic ischia (HP:0003175)1.71890979
105Cutaneous finger syndactyly (HP:0010554)1.71106264
106Limb-girdle muscle weakness (HP:0003325)1.70383192
107Sparse eyelashes (HP:0000653)1.70055786
108Hip contracture (HP:0003273)1.68873975
109Turricephaly (HP:0000262)1.68707924
110Sudden death (HP:0001699)1.68545894
111Pterygium (HP:0001059)1.67991616
112Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67831371
113Vascular tortuosity (HP:0004948)1.67689955
114Woolly hair (HP:0002224)1.67499430
115Trismus (HP:0000211)1.67211359
116Short hallux (HP:0010109)1.66490676
117Renovascular hypertension (HP:0100817)1.66144430
118Onycholysis (HP:0001806)1.65777469
119Generalized amyotrophy (HP:0003700)1.65456140
120Radial bowing (HP:0002986)1.63264330
121Breech presentation (HP:0001623)1.63038825
122Broad long bones (HP:0005622)1.62715248
123Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62353137
124Fragile nails (HP:0001808)1.61827042
125Increased density of long bones (HP:0006392)1.61679714
126Broad thumb (HP:0011304)1.61219621
127Venous abnormality (HP:0002624)1.58773891
128Neonatal death (HP:0003811)1.58662190
129Arterial tortuosity (HP:0005116)1.58259880
130Abnormality of the distal phalanges of the toes (HP:0010182)1.58152868
131Cutaneous syndactyly (HP:0012725)1.57839820
132Disproportionate tall stature (HP:0001519)1.56444370
133Protruding ear (HP:0000411)1.55968727
134Aplasia/Hypoplasia of the hallux (HP:0008362)1.55697738
135Hematochezia (HP:0002573)1.55336983
136Limited hip movement (HP:0008800)1.55223705
137Upper limb amyotrophy (HP:0009129)1.54883237
138Distal upper limb amyotrophy (HP:0007149)1.54883237
139Preaxial foot polydactyly (HP:0001841)1.54879617
140Labial hypoplasia (HP:0000066)1.52923338
141Abnormalities of placenta or umbilical cord (HP:0001194)1.51555536
142Abnormality of placental membranes (HP:0011409)1.51331001
143Amniotic constriction ring (HP:0009775)1.51331001
144Hypodontia (HP:0000668)1.51010257
145Abnormality of the salivary glands (HP:0010286)1.50152040
146Aplasia involving bones of the extremities (HP:0009825)1.48006667
147Aplasia involving bones of the upper limbs (HP:0009823)1.48006667
148Aplasia of the phalanges of the hand (HP:0009802)1.48006667
149Hypoplastic female external genitalia (HP:0012815)1.47295318
150Pulmonary artery stenosis (HP:0004415)1.46800111
151Congenital glaucoma (HP:0001087)1.45451630
152Abnormality of molar morphology (HP:0011070)1.44094177
153Abnormality of molar (HP:0011077)1.44094177
154Astrocytoma (HP:0009592)1.43269971
155Abnormality of the astrocytes (HP:0100707)1.43269971
156Abnormality of the dental root (HP:0006486)1.42688168
157Taurodontia (HP:0000679)1.42688168
158Abnormality of permanent molar morphology (HP:0011071)1.42688168
159Abnormality of the phalanges of the hallux (HP:0010057)1.41295478
160Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.41125573
161Ependymoma (HP:0002888)1.40518765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.10648274
2DDR23.59325346
3TTN3.49020737
4PKN23.36414620
5LATS13.24618107
6PDGFRA3.15064616
7RIPK12.65271734
8EPHB22.56439976
9EPHA22.52981249
10EEF2K2.19052760
11LATS22.19013135
12CDK121.96994628
13MAP3K101.96048653
14FER1.92279129
15PNCK1.91626110
16PAK41.88006775
17PTK61.86112117
18SIK11.74486880
19DMPK1.67977872
20LRRK21.59427710
21TGFBR21.55957142
22BMX1.55871868
23PBK1.54029402
24PAK21.53929053
25WEE11.52928904
26LMTK21.47721485
27PTK21.44649345
28ICK1.42039004
29MET1.41979461
30FGFR11.38545346
31STK31.33019273
32FGFR21.32774283
33PDGFRB1.29451700
34CASK1.25886920
35MTOR1.25029007
36ILK1.24376167
37SMG11.22062534
38TNIK1.20239300
39CDK61.15346907
40EIF2AK11.15178656
41ERN11.12452639
42RPS6KB21.06237051
43MST1R1.05858487
44TRPM71.05417517
45ERBB41.04466163
46TSSK61.04462369
47MKNK11.03770572
48EPHA31.00924042
49TYRO31.00025194
50TGFBR10.99211061
51STK100.97901654
52BRSK20.95738008
53NEK10.93621638
54PDK20.92258094
55ARAF0.87304095
56MKNK20.85348333
57STK38L0.83223899
58FGFR40.82776843
59TIE10.80772927
60EPHB10.79821668
61ROCK10.79330739
62PAK30.75373820
63NEK60.74911456
64CAMK1D0.74872839
65ALK0.74026176
66STK390.73731731
67PIM20.73434076
68MYLK0.73214892
69STK240.72047261
70PLK20.71831871
71FRK0.71391036
72KSR10.68760213
73MAPKAPK50.68468902
74BRD40.67958020
75ROCK20.67746263
76MOS0.66450433
77FGFR30.65917596
78MAP3K30.65710502
79MUSK0.64212181
80PRKCE0.64066443
81EIF2AK30.63652372
82TESK10.63061169
83EPHA40.62750070
84MAPKAPK30.62524050
85MAP3K80.61503709
86RET0.61188436
87CDC42BPA0.61181046
88MAP2K10.59098757
89PRKD10.58929672
90BMPR1B0.57553918
91MAP3K20.57480231
92RPS6KA40.57277763
93PRKD30.57063665
94ERBB20.56416266
95MAP3K70.55081928
96CLK10.54811247
97PRKG20.52361111
98MAP3K120.51685830
99PIK3CA0.50021811
100GSK3A0.49039432
101AKT20.48174154
102MAP2K20.47767198
103RAF10.47134118
104TAOK10.46597398
105ERBB30.45980765
106MAP3K90.45591989
107FLT30.45048533
108CAMK1G0.44739567
109NTRK10.44559762
110KSR20.43026842
111RPS6KA20.42771273
112PLK30.42757858
113SCYL20.42651508
114LIMK10.42613371
115PRKCI0.41839161
116PRKD20.40698289
117BRSK10.40196301
118MELK0.40131946
119PAK60.40070839
120NEK90.39431225
121CSNK1G10.38817069
122TTK0.38765346
123TRIM280.38589384
124DYRK1B0.38577684
125CDK70.37722679
126CAMK2D0.36365139
127SRC0.36308956
128NEK20.36036080
129INSR0.35966864
130CAMK2G0.35915101
131MAP4K20.34932149
132STK380.32871593
133CDK40.31986226
134PTK2B0.31555543
135RPS6KA10.31469033
136PDK30.30741584
137PDK40.30741584
138RPS6KC10.30533606
139RPS6KL10.30533606

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.63180651
2Focal adhesion_Homo sapiens_hsa045102.75578884
3Adherens junction_Homo sapiens_hsa045202.70874309
4Basal cell carcinoma_Homo sapiens_hsa052172.49316877
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.47972125
6Hippo signaling pathway_Homo sapiens_hsa043902.42755798
7Proteoglycans in cancer_Homo sapiens_hsa052052.23820139
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.14182717
9Dilated cardiomyopathy_Homo sapiens_hsa054142.14081549
10Small cell lung cancer_Homo sapiens_hsa052222.10286006
11Protein digestion and absorption_Homo sapiens_hsa049742.05507972
12Tight junction_Homo sapiens_hsa045301.95858306
13Hedgehog signaling pathway_Homo sapiens_hsa043401.94011109
14Bladder cancer_Homo sapiens_hsa052191.88872345
15Amoebiasis_Homo sapiens_hsa051461.87789130
16MicroRNAs in cancer_Homo sapiens_hsa052061.81838781
17TGF-beta signaling pathway_Homo sapiens_hsa043501.78266987
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.75570064
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.72666950
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.71028648
21Steroid biosynthesis_Homo sapiens_hsa001001.68550422
22Viral myocarditis_Homo sapiens_hsa054161.64053079
23Chronic myeloid leukemia_Homo sapiens_hsa052201.60785916
24Endometrial cancer_Homo sapiens_hsa052131.45290562
25Notch signaling pathway_Homo sapiens_hsa043301.43138757
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.38494623
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.35210478
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.34832264
29Wnt signaling pathway_Homo sapiens_hsa043101.32706686
30Pathways in cancer_Homo sapiens_hsa052001.30159557
31Colorectal cancer_Homo sapiens_hsa052101.29722940
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.27078109
33Thyroid cancer_Homo sapiens_hsa052161.23499213
34Melanoma_Homo sapiens_hsa052181.20962827
35Axon guidance_Homo sapiens_hsa043601.17743492
36Vitamin B6 metabolism_Homo sapiens_hsa007501.17736152
37mTOR signaling pathway_Homo sapiens_hsa041501.16773902
38Renal cell carcinoma_Homo sapiens_hsa052111.15375720
39Sphingolipid metabolism_Homo sapiens_hsa006001.15038514
40Glioma_Homo sapiens_hsa052141.11720420
41Rap1 signaling pathway_Homo sapiens_hsa040151.09594502
42Prostate cancer_Homo sapiens_hsa052151.09165669
43Pancreatic cancer_Homo sapiens_hsa052121.09131381
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08920769
45Toxoplasmosis_Homo sapiens_hsa051451.06770945
46Melanogenesis_Homo sapiens_hsa049161.06454342
47Dorso-ventral axis formation_Homo sapiens_hsa043201.05936806
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05328049
49N-Glycan biosynthesis_Homo sapiens_hsa005101.04956641
50HTLV-I infection_Homo sapiens_hsa051661.00262093
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97022267
52VEGF signaling pathway_Homo sapiens_hsa043700.96506182
53Estrogen signaling pathway_Homo sapiens_hsa049150.96245487
54Non-homologous end-joining_Homo sapiens_hsa034500.92001148
55Platelet activation_Homo sapiens_hsa046110.90940686
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90403844
57HIF-1 signaling pathway_Homo sapiens_hsa040660.87473876
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86807838
59Protein export_Homo sapiens_hsa030600.86304930
60Gap junction_Homo sapiens_hsa045400.84241561
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82375899
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81892525
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81226926
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80904731
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79731033
66Insulin resistance_Homo sapiens_hsa049310.79502449
67Prion diseases_Homo sapiens_hsa050200.78543386
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78394593
69Renin-angiotensin system_Homo sapiens_hsa046140.77600687
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.75708963
71Biosynthesis of amino acids_Homo sapiens_hsa012300.74811842
72AMPK signaling pathway_Homo sapiens_hsa041520.73874390
73Acute myeloid leukemia_Homo sapiens_hsa052210.73212717
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.73099483
75Galactose metabolism_Homo sapiens_hsa000520.72785199
76Propanoate metabolism_Homo sapiens_hsa006400.72607183
77Non-small cell lung cancer_Homo sapiens_hsa052230.72299729
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.71717480
79Insulin signaling pathway_Homo sapiens_hsa049100.70963802
80p53 signaling pathway_Homo sapiens_hsa041150.69750564
81Pyruvate metabolism_Homo sapiens_hsa006200.69702752
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69377824
83Lysine degradation_Homo sapiens_hsa003100.68900621
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68233536
85GnRH signaling pathway_Homo sapiens_hsa049120.68164663
86Ovarian steroidogenesis_Homo sapiens_hsa049130.67108022
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66772087
88Fatty acid elongation_Homo sapiens_hsa000620.66020414
89Viral carcinogenesis_Homo sapiens_hsa052030.63732385
90ErbB signaling pathway_Homo sapiens_hsa040120.63168216
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62331497
92Salmonella infection_Homo sapiens_hsa051320.61696653
93Pentose phosphate pathway_Homo sapiens_hsa000300.60567357
94Mineral absorption_Homo sapiens_hsa049780.60322372
95Fatty acid biosynthesis_Homo sapiens_hsa000610.58779177
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58447288
97Endocytosis_Homo sapiens_hsa041440.58165072
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58140791
99Carbon metabolism_Homo sapiens_hsa012000.57308832
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56908735
101Malaria_Homo sapiens_hsa051440.56383588
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56059205
103FoxO signaling pathway_Homo sapiens_hsa040680.55760170
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54602689
105Arginine and proline metabolism_Homo sapiens_hsa003300.54527371
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54450167
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53979390
108TNF signaling pathway_Homo sapiens_hsa046680.53101192
109Shigellosis_Homo sapiens_hsa051310.52734159
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.52462716
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.51930111
112Cell cycle_Homo sapiens_hsa041100.50499711
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50052195
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49523477
115Apoptosis_Homo sapiens_hsa042100.49506710
116Ras signaling pathway_Homo sapiens_hsa040140.48839082
117MAPK signaling pathway_Homo sapiens_hsa040100.48833711
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48375800
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48185496
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.47786724
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46907986
122Thyroid hormone synthesis_Homo sapiens_hsa049180.46870243
123Sulfur metabolism_Homo sapiens_hsa009200.46779954
124Pancreatic secretion_Homo sapiens_hsa049720.46524798
125Oxytocin signaling pathway_Homo sapiens_hsa049210.46332425
126Glutathione metabolism_Homo sapiens_hsa004800.45962361
127Prolactin signaling pathway_Homo sapiens_hsa049170.45841622
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43263025
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43249024
130Gastric acid secretion_Homo sapiens_hsa049710.43064138
131Renin secretion_Homo sapiens_hsa049240.42288106
132Hepatitis B_Homo sapiens_hsa051610.42255191
133Fatty acid metabolism_Homo sapiens_hsa012120.41620866
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41563310
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.38170023
136Oocyte meiosis_Homo sapiens_hsa041140.37493616
137Vibrio cholerae infection_Homo sapiens_hsa051100.36663958
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36551236
139Fructose and mannose metabolism_Homo sapiens_hsa000510.35141301

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