PTGR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.31500267
2doxorubicin metabolic process (GO:0044598)8.31500267
3daunorubicin metabolic process (GO:0044597)8.31500267
4cellular glucuronidation (GO:0052695)7.49893082
5aminoglycoside antibiotic metabolic process (GO:0030647)7.43588063
6exogenous drug catabolic process (GO:0042738)7.32561210
7glucuronate metabolic process (GO:0019585)7.31144889
8uronic acid metabolic process (GO:0006063)7.31144889
9drug catabolic process (GO:0042737)6.90636710
10epoxygenase P450 pathway (GO:0019373)6.26113260
11glyoxylate metabolic process (GO:0046487)5.87351494
12L-phenylalanine catabolic process (GO:0006559)5.86044011
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.86044011
14L-phenylalanine metabolic process (GO:0006558)5.66735141
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.66735141
16primary alcohol catabolic process (GO:0034310)5.60047379
17omega-hydroxylase P450 pathway (GO:0097267)5.42736288
18drug metabolic process (GO:0017144)5.34532626
19desmosome organization (GO:0002934)5.25267191
20negative regulation of fibrinolysis (GO:0051918)5.22780886
21regulation of fibrinolysis (GO:0051917)5.16792171
22bile acid biosynthetic process (GO:0006699)5.06874526
23bile acid metabolic process (GO:0008206)4.98544896
24intestinal cholesterol absorption (GO:0030299)4.92644911
25phenylpropanoid metabolic process (GO:0009698)4.90182818
26flavonoid metabolic process (GO:0009812)4.89818106
27urea metabolic process (GO:0019627)4.79259887
28glycoside metabolic process (GO:0016137)4.77198726
29phospholipid efflux (GO:0033700)4.73615200
30fibrinolysis (GO:0042730)4.71833433
31aromatic amino acid family catabolic process (GO:0009074)4.71586962
32viral transcription (GO:0019083)4.68470230
33regulation of water loss via skin (GO:0033561)4.68278280
34establishment of skin barrier (GO:0061436)4.67549375
35ribosomal small subunit assembly (GO:0000028)4.63280922
36bile acid and bile salt transport (GO:0015721)4.62318438
37regulation of protein activation cascade (GO:2000257)4.59193743
38regulation of triglyceride catabolic process (GO:0010896)4.59093944
39translational termination (GO:0006415)4.54501322
40interferon-gamma secretion (GO:0072643)4.48153903
41oxidative demethylation (GO:0070989)4.45242293
42negative regulation of cholesterol transport (GO:0032375)4.38681709
43negative regulation of sterol transport (GO:0032372)4.38681709
44ethanol oxidation (GO:0006069)4.34085226
45regulation of cholesterol esterification (GO:0010872)4.33776291
46ribosomal small subunit biogenesis (GO:0042274)4.33325775
47complement activation, alternative pathway (GO:0006957)4.32234494
48nitrogen cycle metabolic process (GO:0071941)4.22636410
49sphingoid metabolic process (GO:0046519)4.18139674
50regulation of complement activation (GO:0030449)4.17522517
51amino-acid betaine metabolic process (GO:0006577)4.15229206
52heme transport (GO:0015886)4.15101391
53high-density lipoprotein particle remodeling (GO:0034375)4.14657914
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.00898930
55negative regulation of lipase activity (GO:0060192)3.96453669
56very-low-density lipoprotein particle assembly (GO:0034379)3.96428724
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.96420008
58translational elongation (GO:0006414)3.95526850
59fat-soluble vitamin biosynthetic process (GO:0042362)3.95518551
60maturation of SSU-rRNA (GO:0030490)3.95514973
61acylglycerol homeostasis (GO:0055090)3.95486599
62triglyceride homeostasis (GO:0070328)3.95486599
63peptidyl-glutamic acid carboxylation (GO:0017187)3.95290405
64protein carboxylation (GO:0018214)3.95290405
65urea cycle (GO:0000050)3.95207496
66positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.95082090
67hormone catabolic process (GO:0042447)3.92978613
68quinone metabolic process (GO:1901661)3.91954285
69protein targeting to ER (GO:0045047)3.85984044
70cotranslational protein targeting to membrane (GO:0006613)3.84726401
71cholesterol efflux (GO:0033344)3.82598232
72formation of translation preinitiation complex (GO:0001731)3.79411300
73S-adenosylmethionine metabolic process (GO:0046500)3.78903598
74ribosomal large subunit biogenesis (GO:0042273)3.76231481
75drug transmembrane transport (GO:0006855)3.74310398
76reverse cholesterol transport (GO:0043691)3.73961612
77serine family amino acid catabolic process (GO:0009071)3.70514689
78xenobiotic catabolic process (GO:0042178)3.69945534
79negative regulation of hemostasis (GO:1900047)3.69852093
80negative regulation of blood coagulation (GO:0030195)3.69852093
81indole-containing compound catabolic process (GO:0042436)3.69847364
82indolalkylamine catabolic process (GO:0046218)3.69847364
83tryptophan catabolic process (GO:0006569)3.69847364
84translational initiation (GO:0006413)3.69333549
85establishment of protein localization to endoplasmic reticulum (GO:0072599)3.67384130
86viral life cycle (GO:0019058)3.65245180
87triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.63834352
88amino sugar catabolic process (GO:0046348)3.63595626
89protein localization to endoplasmic reticulum (GO:0070972)3.62570992
90sphingosine metabolic process (GO:0006670)3.61107701
91protein-lipid complex remodeling (GO:0034368)3.60868730
92macromolecular complex remodeling (GO:0034367)3.60868730
93plasma lipoprotein particle remodeling (GO:0034369)3.60868730
94arginine metabolic process (GO:0006525)3.60266696
95ethanol metabolic process (GO:0006067)3.56586129
96L-ascorbic acid metabolic process (GO:0019852)3.56075317
97alkaloid metabolic process (GO:0009820)3.54995536
98glycine metabolic process (GO:0006544)3.54478640
99negative regulation of coagulation (GO:0050819)3.54203861
100intestinal absorption (GO:0050892)3.53872491
101plasma lipoprotein particle assembly (GO:0034377)3.52026426
102xenobiotic metabolic process (GO:0006805)3.50693262
103cellular protein complex disassembly (GO:0043624)3.49713280
104intestinal epithelial cell development (GO:0060576)3.49269089
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.48765991
106phospholipid homeostasis (GO:0055091)3.44815248
107regulation of plasminogen activation (GO:0010755)3.44255589
108cellular aldehyde metabolic process (GO:0006081)3.43948068
109cysteine metabolic process (GO:0006534)3.43623163
110retinal metabolic process (GO:0042574)3.41625716
111diol metabolic process (GO:0034311)3.41557055
112blood coagulation, intrinsic pathway (GO:0007597)3.40629333
113negative regulation of wound healing (GO:0061045)3.40400815
114phospholipid scrambling (GO:0017121)3.40364918
115serine family amino acid metabolic process (GO:0009069)3.30254096
116response to nitrosative stress (GO:0051409)3.29835009
117primary alcohol metabolic process (GO:0034308)3.28750406
118drug transport (GO:0015893)3.25268809
119regulation of chemokine secretion (GO:0090196)3.23614436
120vitamin biosynthetic process (GO:0009110)3.23160765
121coenzyme catabolic process (GO:0009109)3.22252459
122L-methionine salvage (GO:0071267)3.19608810
123L-methionine biosynthetic process (GO:0071265)3.19608810
124amino acid salvage (GO:0043102)3.19608810
125tyrosine metabolic process (GO:0006570)3.19175820
126aromatic amino acid family metabolic process (GO:0009072)3.17934208
127cellular ketone body metabolic process (GO:0046950)3.14097475
128antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09750295
129protein-lipid complex assembly (GO:0065005)3.06352393
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.04950101
131protein localization to kinetochore (GO:0034501)2.95424560
132protein complex disassembly (GO:0043241)2.94444938
133translation (GO:0006412)2.92520571
134lipoxygenase pathway (GO:0019372)2.91688510
135neutrophil activation involved in immune response (GO:0002283)2.90957792
136ribonucleoprotein complex biogenesis (GO:0022613)2.88021296
137multicellular organismal water homeostasis (GO:0050891)2.87293311
138keratinization (GO:0031424)2.86976101
139bundle of His cell to Purkinje myocyte communication (GO:0086069)2.86351387
140DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86027897
141positive regulation of Cdc42 GTPase activity (GO:0043089)2.84115868
142maintenance of gastrointestinal epithelium (GO:0030277)2.82455163
143DNA strand elongation involved in DNA replication (GO:0006271)2.81695093
144signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80394910
145intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80394910
146negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.79150319
147signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79147653
148signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79147653
149signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79147653
150nucleobase-containing small molecule interconversion (GO:0015949)2.78467110
151negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.78135904
152regulation of cellular amino acid metabolic process (GO:0006521)2.76865967
153proteasome assembly (GO:0043248)2.76756259
154telomere maintenance via semi-conservative replication (GO:0032201)2.76159547
155macromolecular complex disassembly (GO:0032984)2.74786747
156keratinocyte differentiation (GO:0030216)2.74160505
157neutrophil mediated immunity (GO:0002446)2.74055616
158signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73882332
159signal transduction involved in DNA damage checkpoint (GO:0072422)2.73882332
160positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72845966
161anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72063363
162positive regulation of chemokine secretion (GO:0090197)2.70574874
163reactive oxygen species biosynthetic process (GO:1903409)2.70544561
164regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69736132
165signal transduction involved in cell cycle checkpoint (GO:0072395)2.67970995
166keratinocyte proliferation (GO:0043616)2.64557153
167DNA strand elongation (GO:0022616)2.63481707
168kinetochore organization (GO:0051383)2.62462591
169DNA replication checkpoint (GO:0000076)2.62459083
170regulation of transforming growth factor beta1 production (GO:0032908)2.60333362
171telomere maintenance via recombination (GO:0000722)2.60115490
172kinetochore assembly (GO:0051382)2.59787466
173mitotic metaphase plate congression (GO:0007080)2.59576293
174protein targeting to membrane (GO:0006612)2.58702338
175regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58584079
176* cyclooxygenase pathway (GO:0019371)2.58451893
177ribosome assembly (GO:0042255)2.57082055
178glucosamine-containing compound catabolic process (GO:1901072)2.54582598
179DNA deamination (GO:0045006)2.54259802
180hepatocyte apoptotic process (GO:0097284)2.49594280
181antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.49514336
182negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.48087699
183negative regulation of ligase activity (GO:0051352)2.48087699
184nuclear-transcribed mRNA catabolic process (GO:0000956)2.47835131
185positive regulation of cell cycle arrest (GO:0071158)2.45762596
186Arp2/3 complex-mediated actin nucleation (GO:0034314)2.45648058
187mitotic recombination (GO:0006312)2.42921769
188protein localization to chromosome, centromeric region (GO:0071459)2.40276733
189immunoglobulin mediated immune response (GO:0016064)2.38755198
190water homeostasis (GO:0030104)2.37060917
191leukotriene biosynthetic process (GO:0019370)2.35324020
192cell differentiation involved in embryonic placenta development (GO:0060706)2.34504663
193positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.34503616
194mRNA catabolic process (GO:0006402)2.33875456
195regulation of hypersensitivity (GO:0002883)2.33755846
196negative regulation of stress fiber assembly (GO:0051497)2.33572514
197hydrogen peroxide biosynthetic process (GO:0050665)2.32940523
198epidermal cell differentiation (GO:0009913)2.32570654
199detection of other organism (GO:0098543)2.31532986
200regulation of cell proliferation involved in kidney development (GO:1901722)2.30486365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.15807501
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.40723012
3E2F7_22180533_ChIP-Seq_HELA_Human5.61083852
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.91626469
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.58323298
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.26310512
7RXR_22158963_ChIP-Seq_LIVER_Mouse4.26272517
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.79383569
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.59877600
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.05157155
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.00539498
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.99202427
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.92774122
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90568044
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.88526724
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.60461576
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43874789
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.43656478
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43206438
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27921132
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24204648
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.18310252
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17805850
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16393131
25CDX2_20551321_ChIP-Seq_CACO-2_Human2.02748286
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.96110318
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95775255
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.91902696
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.88061825
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87727702
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87064484
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80056001
33* HNF4A_19822575_ChIP-Seq_HepG2_Human1.75510203
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.71968374
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70628106
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70569939
37AR_21909140_ChIP-Seq_LNCAP_Human1.67131789
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66303039
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62470237
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59508874
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55471109
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54762530
43XRN2_22483619_ChIP-Seq_HELA_Human1.48869649
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48751067
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48751067
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48751067
47DCP1A_22483619_ChIP-Seq_HELA_Human1.47441499
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47433044
49* PIAS1_25552417_ChIP-Seq_VCAP_Human1.45708186
50HTT_18923047_ChIP-ChIP_STHdh_Human1.44969024
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44739151
52* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42213580
53* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42213580
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42037612
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.41979862
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41475985
57VDR_23849224_ChIP-Seq_CD4+_Human1.40724998
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38327407
59CJUN_26792858_Chip-Seq_BT549_Human1.37706770
60ELK1_19687146_ChIP-ChIP_HELA_Human1.37188930
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.35558735
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34894484
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.34865482
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34234984
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33430260
66SPI1_23547873_ChIP-Seq_NB4_Human1.32136341
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31770599
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30054780
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29460491
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28682460
71TP53_18474530_ChIP-ChIP_U2OS_Human1.27643448
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26590295
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26246077
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26067736
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26067736
76TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25929684
77TTF2_22483619_ChIP-Seq_HELA_Human1.25793007
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24948264
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.24472856
80CDX2_22108803_ChIP-Seq_LS180_Human1.24096825
81* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.24036391
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23298266
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23141188
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22894537
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22115054
86BCAT_22108803_ChIP-Seq_LS180_Human1.22006765
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21809839
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.20505677
89* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18880293
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.18128348
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16917072
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16635409
93* GATA4_25053715_ChIP-Seq_YYC3_Human1.16309613
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15883761
95CBP_21632823_ChIP-Seq_H3396_Human1.14898553
96AR_20517297_ChIP-Seq_VCAP_Human1.13882622
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13872073
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13683202
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12817085
100TRIM28_21343339_ChIP-Seq_HEK293_Human1.12019829
101EOMES_21245162_ChIP-Seq_HESCs_Human1.11918038
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10495704
103* ATF3_27146783_Chip-Seq_COLON_Human1.10016273
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09833026
105SMAD3_21741376_ChIP-Seq_HESCs_Human1.09586958
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09437989
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08720885
108* P300_19829295_ChIP-Seq_ESCs_Human1.08690512
109ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08144569
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.06747747
111HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06546870
112* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05881078
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.05693306
114* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05319125
115KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05173103
116TFEB_21752829_ChIP-Seq_HELA_Human1.04757908
117VDR_22108803_ChIP-Seq_LS180_Human1.04705619
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04373319
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04132515
120TCF4_22108803_ChIP-Seq_LS180_Human1.03843074
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03416826
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02284003
123RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02075101
124E2F1_21310950_ChIP-Seq_MCF-7_Human1.01419146
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00208603
126BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99648697
127FOXP3_21729870_ChIP-Seq_TREG_Human0.99546903
128FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99138685
129* NANOG_19829295_ChIP-Seq_ESCs_Human0.98861577
130* SOX2_19829295_ChIP-Seq_ESCs_Human0.98861577
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98709538
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98535087
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98438400
134SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98414604
135GABP_19822575_ChIP-Seq_HepG2_Human0.98263330
136* GATA6_25053715_ChIP-Seq_YYC3_Human0.98256699
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97614994
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.96889253
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96693792
140SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96322500
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95826831
142NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95782978
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.95333917
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.94443309
145* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94182317
146ESR2_21235772_ChIP-Seq_MCF-7_Human0.94079403
147HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94073285
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93324374
149OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92446830
150PHF8_20622853_ChIP-Seq_HELA_Human0.91565693
151ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91413564
152ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90958000
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.90650652
154SOX2_20726797_ChIP-Seq_SW620_Human0.89846019
155HNFA_21074721_ChIP-Seq_CACO-2_Human0.89453073
156* FOXA1_25552417_ChIP-Seq_VCAP_Human0.89294398
157NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89232437
158MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88956036
159* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88927624
160* FOXA1_25329375_ChIP-Seq_VCAP_Human0.88927624
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88911523
162SMAD3_21741376_ChIP-Seq_EPCs_Human0.88793398
163CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88723970
164SRF_21415370_ChIP-Seq_HL-1_Mouse0.88660491
165SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88489819
166ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87517845
167TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86927806
168MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86753860
169* CBP_20019798_ChIP-Seq_JUKART_Human0.86632218
170* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86632218
171IGF1R_20145208_ChIP-Seq_DFB_Human0.86351211
172CRX_20693478_ChIP-Seq_RETINA_Mouse0.85993902
173* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85901921
174VDR_21846776_ChIP-Seq_THP-1_Human0.85574907
175IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85564355
176UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84926074
177NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84799760
178EP300_21415370_ChIP-Seq_HL-1_Mouse0.84138835
179EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83965862
180CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83153655
181NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82282773
182* GATA3_24758297_ChIP-Seq_MCF-7_Human0.81138068
183CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79450683
184NFYA_21822215_ChIP-Seq_K562_Human0.78731538
185STAT3_18555785_Chip-Seq_ESCs_Mouse0.78022574
186ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77426107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.79806502
2MP0005365_abnormal_bile_salt5.72949544
3MP0005085_abnormal_gallbladder_physiolo5.69669617
4MP0008004_abnormal_stomach_pH5.50136785
5MP0005360_urolithiasis5.47022119
6MP0008875_abnormal_xenobiotic_pharmacok4.64195318
7MP0003195_calcinosis4.50471993
8MP0002796_impaired_skin_barrier4.27399577
9MP0001666_abnormal_nutrient_absorption4.09402102
10MP0010234_abnormal_vibrissa_follicle3.85109589
11MP0003252_abnormal_bile_duct3.61716589
12MP0002138_abnormal_hepatobiliary_system3.57811430
13MP0003693_abnormal_embryo_hatching3.34191583
14MP0003941_abnormal_skin_development3.23909523
15MP0003868_abnormal_feces_composition3.14526957
16MP0005275_abnormal_skin_tensile3.00223212
17MP0005501_abnormal_skin_physiology2.84285516
18MP0010352_gastrointestinal_tract_polyps2.64343920
19MP0010329_abnormal_lipoprotein_level2.61062579
20MP0005332_abnormal_amino_acid2.50680140
21MP0004957_abnormal_blastocyst_morpholog2.45703454
22MP0002060_abnormal_skin_morphology2.20069693
23MP0004381_abnormal_hair_follicle2.14068179
24MP0009697_abnormal_copulation2.13037922
25MP0001216_abnormal_epidermal_layer2.10127314
26MP0003453_abnormal_keratinocyte_physiol1.97777521
27MP0002876_abnormal_thyroid_physiology1.89018190
28MP0001873_stomach_inflammation1.87512984
29MP0005451_abnormal_body_composition1.86784707
30MP0003111_abnormal_nucleus_morphology1.86641736
31MP0004947_skin_inflammation1.85695279
32MP0003566_abnormal_cell_adhesion1.83275219
33MP0002098_abnormal_vibrissa_morphology1.77952734
34MP0003705_abnormal_hypodermis_morpholog1.72863956
35MP0003436_decreased_susceptibility_to1.69325061
36MP0003186_abnormal_redox_activity1.64487743
37MP0010094_abnormal_chromosome_stability1.64086058
38MP0000490_abnormal_crypts_of1.63895159
39MP0001764_abnormal_homeostasis1.62266447
40MP0010771_integument_phenotype1.55459804
41MP0003077_abnormal_cell_cycle1.55001026
42MP0000377_abnormal_hair_follicle1.54307842
43MP0004782_abnormal_surfactant_physiolog1.48335324
44MP0002148_abnormal_hypersensitivity_rea1.48091930
45MP0000470_abnormal_stomach_morphology1.46203326
46MP0002118_abnormal_lipid_homeostasis1.45785512
47MP0000647_abnormal_sebaceous_gland1.40331274
48MP0000609_abnormal_liver_physiology1.38849386
49MP0001243_abnormal_dermal_layer1.33361075
50MP0005408_hypopigmentation1.31454793
51MP0010678_abnormal_skin_adnexa1.26793856
52MP0002009_preneoplasia1.26684085
53MP0004272_abnormal_basement_membrane1.26555422
54MP0009785_altered_susceptibility_to1.25119639
55MP0003890_abnormal_embryonic-extraembry1.24631899
56MP0004264_abnormal_extraembryonic_tissu1.22962806
57MP0009643_abnormal_urine_homeostasis1.22806496
58MP0003950_abnormal_plasma_membrane1.22703205
59MP0003806_abnormal_nucleotide_metabolis1.20426394
60MP0005023_abnormal_wound_healing1.19794213
61MP0005076_abnormal_cell_differentiation1.19567671
62MP0009931_abnormal_skin_appearance1.15731079
63MP0002006_tumorigenesis1.14715729
64MP0006054_spinal_hemorrhage1.13260794
65MP0009379_abnormal_foot_pigmentation1.13119019
66MP0005319_abnormal_enzyme/_coenzyme1.12808435
67MP0008932_abnormal_embryonic_tissue1.12353304
68MP0000858_altered_metastatic_potential1.11970249
69MP0003786_premature_aging1.11365305
70MP0005636_abnormal_mineral_homeostasis1.10509248
71MP0003315_abnormal_perineum_morphology1.10415381
72MP0010155_abnormal_intestine_physiology1.09565967
73MP0005367_renal/urinary_system_phenotyp1.09241533
74MP0000516_abnormal_urinary_system1.09241533
75MP0001835_abnormal_antigen_presentation1.09222470
76MP0003718_maternal_effect1.07848929
77MP0002419_abnormal_innate_immunity1.06715943
78MP0010030_abnormal_orbit_morphology1.05553874
79MP0001191_abnormal_skin_condition1.05112048
80MP0001853_heart_inflammation1.05089744
81MP0008057_abnormal_DNA_replication1.04728486
82MP0005025_abnormal_response_to1.04430698
83MP0003191_abnormal_cellular_cholesterol1.03177583
84MP0002254_reproductive_system_inflammat1.02736392
85MP0010307_abnormal_tumor_latency1.02734533
86MP0005670_abnormal_white_adipose1.01753956
87MP0002019_abnormal_tumor_incidence0.98022748
88MP0000367_abnormal_coat/_hair0.97892519
89MP0005584_abnormal_enzyme/coenzyme_acti0.92293940
90MP0002166_altered_tumor_susceptibility0.92121780
91MP0000477_abnormal_intestine_morphology0.91511745
92MP0001545_abnormal_hematopoietic_system0.89168927
93MP0005397_hematopoietic_system_phenotyp0.89168927
94MP0002277_abnormal_respiratory_mucosa0.88848856
95MP0003448_altered_tumor_morphology0.88661586
96MP0005075_abnormal_melanosome_morpholog0.88386249
97MP0001542_abnormal_bone_strength0.87978013
98MP0002938_white_spotting0.87694978
99MP0002452_abnormal_antigen_presenting0.86685422
100MP0000350_abnormal_cell_proliferation0.86671456
101MP0005395_other_phenotype0.86102561
102MP0009840_abnormal_foam_cell0.85571619
103MP0008058_abnormal_DNA_repair0.84262270
104MP0005058_abnormal_lysosome_morphology0.84217522
105MP0000383_abnormal_hair_follicle0.84100103
106MP0009333_abnormal_splenocyte_physiolog0.83842235
107MP0003136_yellow_coat_color0.83785196
108MP0001845_abnormal_inflammatory_respons0.83338985
109MP0005000_abnormal_immune_tolerance0.83129879
110MP0000537_abnormal_urethra_morphology0.80978097
111MP0010386_abnormal_urinary_bladder0.80267047
112MP0008007_abnormal_cellular_replicative0.80213706
113MP0002132_abnormal_respiratory_system0.79956803
114MP0002396_abnormal_hematopoietic_system0.78956131
115MP0000427_abnormal_hair_cycle0.77745277
116MP0001661_extended_life_span0.77728923
117MP0002405_respiratory_system_inflammati0.77482807
118MP0001533_abnormal_skeleton_physiology0.76629198
119MP0008438_abnormal_cutaneous_collagen0.75824830
120MP0000465_gastrointestinal_hemorrhage0.74186440
121MP0001819_abnormal_immune_cell0.73287029
122MP0005464_abnormal_platelet_physiology0.73068692
123MP0002420_abnormal_adaptive_immunity0.73005121
124MP0003011_delayed_dark_adaptation0.72746763
125MP0000598_abnormal_liver_morphology0.72611393
126MP0010368_abnormal_lymphatic_system0.72272657
127MP0001730_embryonic_growth_arrest0.71969164
128MP0000627_abnormal_mammary_gland0.71470149
129MP0001664_abnormal_digestion0.71467371
130MP0004133_heterotaxia0.71419880
131MP0008872_abnormal_physiological_respon0.71042285
132MP0009053_abnormal_anal_canal0.70997929
133MP0001756_abnormal_urination0.70626732
134MP0005084_abnormal_gallbladder_morpholo0.70467056
135MP0009780_abnormal_chondrocyte_physiolo0.69502245
136MP0004019_abnormal_vitamin_homeostasis0.69305583
137MP0005376_homeostasis/metabolism_phenot0.68948348
138MP0000343_altered_response_to0.68388664
139MP0004147_increased_porphyrin_level0.67582554
140MP0002723_abnormal_immune_serum0.66013871
141MP0009642_abnormal_blood_homeostasis0.63598711
142MP0002090_abnormal_vision0.63403179
143MP0005187_abnormal_penis_morphology0.61656045
144MP0002136_abnormal_kidney_physiology0.59689408
145MP0000538_abnormal_urinary_bladder0.59464696
146MP0003638_abnormal_response/metabolism_0.55571557
147MP0006036_abnormal_mitochondrial_physio0.53594275
148MP0000462_abnormal_digestive_system0.51255478
149MP0005197_abnormal_uvea_morphology0.51067738
150MP0005248_abnormal_Harderian_gland0.50631874
151MP0002168_other_aberrant_phenotype0.49655754
152MP0000604_amyloidosis0.49091395
153MP0003119_abnormal_digestive_system0.48788908
154MP0002233_abnormal_nose_morphology0.48299896
155MP0000467_abnormal_esophagus_morphology0.47911409
156MP0002697_abnormal_eye_size0.45538844
157MP0001881_abnormal_mammary_gland0.45486575
158MP0008469_abnormal_protein_level0.44946573
159MP0006292_abnormal_olfactory_placode0.44563622
160MP0003283_abnormal_digestive_organ0.43821301
161MP0002282_abnormal_trachea_morphology0.42176355
162MP0005164_abnormal_response_to0.41431846
163MP0002295_abnormal_pulmonary_circulatio0.39818141
164MP0005266_abnormal_metabolism0.38400710
165MP0005448_abnormal_energy_balance0.37999615
166MP0009764_decreased_sensitivity_to0.37753965
167MP0002078_abnormal_glucose_homeostasis0.37489546
168MP0001293_anophthalmia0.36494672
169MP0001915_intracranial_hemorrhage0.36197386
170MP0003879_abnormal_hair_cell0.34701225
171MP0005551_abnormal_eye_electrophysiolog0.34533234
172MP0002837_dystrophic_cardiac_calcinosis0.34299520
173MP0000566_synostosis0.33526845
174MP0003959_abnormal_lean_body0.32437573
175MP0003953_abnormal_hormone_level0.31917649
176MP0005330_cardiomyopathy0.30789730
177MP0004043_abnormal_pH_regulation0.29971629

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)8.10062171
2Hypobetalipoproteinemia (HP:0003563)7.75923994
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.09099321
4Conjugated hyperbilirubinemia (HP:0002908)5.94773627
5Prolonged partial thromboplastin time (HP:0003645)5.78147316
6Deep venous thrombosis (HP:0002625)5.51182643
7Complement deficiency (HP:0004431)5.46395222
8Abnormality of glutamine family amino acid metabolism (HP:0010902)5.41614012
9Intrahepatic cholestasis (HP:0001406)5.31998749
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.19953607
11Hypolipoproteinemia (HP:0010981)5.18790499
12Congenital ichthyosiform erythroderma (HP:0007431)5.13699012
13Fat malabsorption (HP:0002630)5.04233964
14Abnormality of cells of the erythroid lineage (HP:0012130)4.98808842
15Abnormal number of erythroid precursors (HP:0012131)4.84872215
16Reticulocytopenia (HP:0001896)4.67906147
17Steatorrhea (HP:0002570)4.51510353
18Abnormality of complement system (HP:0005339)4.33977123
19Right ventricular cardiomyopathy (HP:0011663)4.18914038
20Increased IgE level (HP:0003212)4.15603090
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.11726021
22Systemic lupus erythematosus (HP:0002725)4.05637992
23Spontaneous abortion (HP:0005268)4.02599838
24Abnormality of proline metabolism (HP:0010907)3.90780665
25Hydroxyprolinuria (HP:0003080)3.90780665
26Xanthomatosis (HP:0000991)3.86138336
27Abnormality of the common coagulation pathway (HP:0010990)3.82080152
28Eczematoid dermatitis (HP:0000976)3.80203865
29Hyperglycinemia (HP:0002154)3.79141488
30Woolly hair (HP:0002224)3.68977427
31Abnormality of pyrimidine metabolism (HP:0004353)3.66799667
32Glomerulonephritis (HP:0000099)3.59995585
33Hyperlipoproteinemia (HP:0010980)3.56118857
34Generalized aminoaciduria (HP:0002909)3.53223156
35Glycosuria (HP:0003076)3.51612834
36Abnormality of urine glucose concentration (HP:0011016)3.51612834
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.47478485
38Hypoalphalipoproteinemia (HP:0003233)3.42835314
39Hyperglycinuria (HP:0003108)3.41091952
40Abnormality of serine family amino acid metabolism (HP:0010894)3.33830289
41Abnormality of glycine metabolism (HP:0010895)3.33830289
42Hyperammonemia (HP:0001987)3.29094034
43Abnormality of methionine metabolism (HP:0010901)3.26430711
44Abnormality of serum amino acid levels (HP:0003112)3.21047535
45Recurrent abscess formation (HP:0002722)3.20690234
46Abnormality of vitamin metabolism (HP:0100508)3.19739756
47Sparse eyelashes (HP:0000653)3.19565877
48Erythema (HP:0010783)3.18362019
49Macrocytic anemia (HP:0001972)3.17179583
50Vascular calcification (HP:0004934)3.14567696
51Trismus (HP:0000211)3.13506435
52Parakeratosis (HP:0001036)3.11961895
53Joint hemorrhage (HP:0005261)3.11643552
54Hypotrichosis (HP:0001006)3.09442781
55Erythroderma (HP:0001019)3.05981290
56Pustule (HP:0200039)3.05859546
57Proximal tubulopathy (HP:0000114)3.03154119
58Breast hypoplasia (HP:0003187)3.01326476
59Rickets (HP:0002748)3.01123056
60Recurrent bacterial skin infections (HP:0005406)2.89134295
61Multiple enchondromatosis (HP:0005701)2.87773559
62Cardiovascular calcification (HP:0011915)2.85166067
63Nephritis (HP:0000123)2.81723677
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.76494094
65Congenital, generalized hypertrichosis (HP:0004540)2.74128425
66Obstructive lung disease (HP:0006536)2.72352184
67Chronic obstructive pulmonary disease (HP:0006510)2.72352184
68Hyperphosphaturia (HP:0003109)2.69664171
69Pallor (HP:0000980)2.67506599
70Vacuolated lymphocytes (HP:0001922)2.66521784
71Delayed CNS myelination (HP:0002188)2.59277154
72Abnormality of macrophages (HP:0004311)2.55729371
73Abnormality of the intrinsic pathway (HP:0010989)2.53640995
74Abnormality of nail color (HP:0100643)2.49999321
75Abnormality of sulfur amino acid metabolism (HP:0004339)2.47616933
76Hyperbilirubinemia (HP:0002904)2.47418076
77Abnormal hemoglobin (HP:0011902)2.43557923
78Abnormality of nucleobase metabolism (HP:0010932)2.42656757
79Metabolic acidosis (HP:0001942)2.42563194
80Palmoplantar hyperkeratosis (HP:0000972)2.42431171
81Lip pit (HP:0100267)2.41469843
82Lethargy (HP:0001254)2.40271545
83Epidermoid cyst (HP:0200040)2.38915269
84Premature ovarian failure (HP:0008209)2.36252648
85Onycholysis (HP:0001806)2.34965792
86Palmar hyperkeratosis (HP:0010765)2.32214769
87Plantar hyperkeratosis (HP:0007556)2.32119114
88Hypoglycemic coma (HP:0001325)2.30777360
89Abnormality of the umbilical cord (HP:0010881)2.30262771
90Reduced antithrombin III activity (HP:0001976)2.27688900
91Petechiae (HP:0000967)2.26300209
92Urticaria (HP:0001025)2.26036567
93Recurrent gram-negative bacterial infections (HP:0005420)2.24703852
94Rough bone trabeculation (HP:0100670)2.24190045
95Hypergammaglobulinemia (HP:0010702)2.24153122
96Gangrene (HP:0100758)2.24097002
97Malnutrition (HP:0004395)2.23756667
98Thrombocytosis (HP:0001894)2.21518732
99Abnormal umbilical cord blood vessels (HP:0011403)2.19964210
100Single umbilical artery (HP:0001195)2.19964210
101Abnormality of the fetal cardiovascular system (HP:0010948)2.19964210
102Cerebral edema (HP:0002181)2.19388351
103Ureteral duplication (HP:0000073)2.19294155
104Poor head control (HP:0002421)2.16827824
105Mitral stenosis (HP:0001718)2.16720733
106Chromsome breakage (HP:0040012)2.16714111
107Absent thumb (HP:0009777)2.15090898
108Abnormal urine phosphate concentration (HP:0012599)2.15073819
109Megaloblastic anemia (HP:0001889)2.14926232
110Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12967069
111Concave nail (HP:0001598)2.10925786
112Hypercholesterolemia (HP:0003124)2.10860268
113Osteomalacia (HP:0002749)2.08889964
114Interstitial pulmonary disease (HP:0006530)2.08190776
115Acute encephalopathy (HP:0006846)2.08086268
116Abnormality of the preputium (HP:0100587)2.06672046
117Blepharitis (HP:0000498)2.06153032
118Granulocytopenia (HP:0001913)2.05448839
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04847560
120Abnormality of alanine metabolism (HP:0010916)2.04847560
121Hyperalaninemia (HP:0003348)2.04847560
122Agnosia (HP:0010524)2.02037869
123Natal tooth (HP:0000695)2.01468686
124Skin ulcer (HP:0200042)1.99702075
125Ectropion (HP:0000656)1.99393009
126Eosinophilia (HP:0001880)1.99382990
127Nausea (HP:0002018)1.97995805
128Anhidrosis (HP:0000970)1.96660606
129Abnormal blistering of the skin (HP:0008066)1.96242432
130Hypophosphatemic rickets (HP:0004912)1.95943902
131Microretrognathia (HP:0000308)1.95376416
132Increased serum pyruvate (HP:0003542)1.94854925
133Cellulitis (HP:0100658)1.93793754
134Irritability (HP:0000737)1.93281202
135Cerebral palsy (HP:0100021)1.91865279
136Periodontitis (HP:0000704)1.88082293
137Nail dystrophy (HP:0008404)1.87959597
138Curly hair (HP:0002212)1.87320527
139Abnormality of vitamin B metabolism (HP:0004340)1.87136410
140Prostate neoplasm (HP:0100787)1.86902743
141Bifid scrotum (HP:0000048)1.86697733
142Glossoptosis (HP:0000162)1.86580937
143Abnormality of purine metabolism (HP:0004352)1.85757923
144Degeneration of anterior horn cells (HP:0002398)1.85404061
145Abnormality of the anterior horn cell (HP:0006802)1.85404061
146Fasciculations (HP:0002380)1.84571598
147Osteolytic defects of the hand bones (HP:0009699)1.84303081
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.84303081
149Pili torti (HP:0003777)1.83958390
150Retinal atrophy (HP:0001105)1.82867557
151Sparse scalp hair (HP:0002209)1.81844745
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.81581501
153Cleft eyelid (HP:0000625)1.81250214
154Mediastinal lymphadenopathy (HP:0100721)1.80214537
155CNS demyelination (HP:0007305)1.79494828
156Enlarged kidneys (HP:0000105)1.79374902
157Pruritus (HP:0000989)1.78903533
158Abnormality of liposaccharide metabolism (HP:0010968)1.77606909
159Abnormality of glycosphingolipid metabolism (HP:0004343)1.77606909
160Abnormality of glycolipid metabolism (HP:0010969)1.77606909
161Distal lower limb muscle weakness (HP:0009053)1.77553115
162Abnormal trabecular bone morphology (HP:0100671)1.77388910
163Gout (HP:0001997)1.76929481
16411 pairs of ribs (HP:0000878)1.76794717
165Sepsis (HP:0100806)1.76301655
166Corneal erosion (HP:0200020)1.76232443
167Renal cortical cysts (HP:0000803)1.76103615
168Stenosis of the external auditory canal (HP:0000402)1.75586108
169Abnormality of glycolysis (HP:0004366)1.74475954
170Bile duct proliferation (HP:0001408)1.72205895
171Abnormal biliary tract physiology (HP:0012439)1.72205895
172Cheilitis (HP:0100825)1.71663381
173Hepatocellular carcinoma (HP:0001402)1.71658293
174Prolonged neonatal jaundice (HP:0006579)1.71405411
175Abnormality of fatty-acid metabolism (HP:0004359)1.71382466
176Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70301256
177Dicarboxylic aciduria (HP:0003215)1.70301256
178Colon cancer (HP:0003003)1.70125268
179Abnormality of the distal phalanges of the toes (HP:0010182)1.69741556
180Abnormality of small intestinal villus morphology (HP:0011472)1.69563859
181Villous atrophy (HP:0011473)1.69563859
182Carpal bone hypoplasia (HP:0001498)1.69419162
183Vomiting (HP:0002013)1.69024160
184Fragile nails (HP:0001808)1.68774306
185Absent radius (HP:0003974)1.67520618
186Acanthocytosis (HP:0001927)1.64581158
187Abnormality of alkaline phosphatase activity (HP:0004379)1.64106363
188Abnormal sex determination (HP:0012244)1.63836929
189Sex reversal (HP:0012245)1.63836929
190Ketosis (HP:0001946)1.62163434
191Elevated alkaline phosphatase (HP:0003155)1.61821044
192Hepatic necrosis (HP:0002605)1.61569053
193Abnormal enzyme/coenzyme activity (HP:0012379)1.60721845
194Fair hair (HP:0002286)1.60281504
195Alkalosis (HP:0001948)1.60214032
196Renal tubular dysfunction (HP:0000124)1.59767921
197Pancreatitis (HP:0001733)1.57833532
198Gingival bleeding (HP:0000225)1.57683933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.51331403
2EPHA23.06401191
3BUB13.00997464
4PIM23.00535368
5NME22.86228707
6PBK2.84604638
7WEE12.74603549
8MAP3K122.70187438
9RPS6KB22.69426687
10MST1R2.66048193
11MAPKAPK32.50236734
12WNK32.36627340
13IRAK32.21516168
14TESK12.18360825
15BMPR1B2.18028319
16STK102.05124400
17MAP3K31.78673927
18EIF2AK11.75983676
19LRRK21.74643893
20BLK1.72072677
21ERBB41.71311651
22MAP3K111.63861244
23NEK21.54999017
24EIF2AK31.53598217
25SRPK11.47449091
26TTK1.37883008
27TNIK1.36372827
28RPS6KA41.35361143
29TRIM281.29860898
30AURKB1.25309734
31NEK91.23672093
32TRPM71.22929293
33CASK1.22846634
34CDC71.19113214
35STK38L1.17691157
36OXSR11.16508751
37STK391.16422179
38PIM11.15841011
39MAP3K141.12718674
40PRKCE1.11742987
41MAP3K81.10971166
42NEK11.10850772
43IRAK41.09825795
44ACVR1B1.07931754
45RIPK41.07879552
46EIF2AK21.07601659
47BCKDK1.06440226
48AURKA1.05450238
49MUSK1.03969860
50FRK1.02538101
51CDK71.02477479
52MAP2K31.01240034
53PRKG21.01082229
54STK41.00266551
55TAOK21.00223888
56STK161.00055862
57BRSK20.99455613
58PLK40.99271544
59ADRBK20.99106887
60PLK10.98765053
61TBK10.98371965
62FER0.96219411
63ABL20.95361991
64PAK40.95267115
65LMTK20.87411506
66PRKCI0.87118443
67ERN10.86791503
68PTK20.85764436
69IKBKB0.84822615
70FLT30.84723394
71TIE10.84394031
72ARAF0.82133318
73DDR20.81983150
74ZAK0.81665531
75TLK10.81573406
76TGFBR20.80976788
77INSRR0.79663059
78MYLK0.79556625
79EPHA40.79501063
80MET0.78496945
81EPHB20.78236651
82TESK20.78135469
83BCR0.77989549
84PDK20.77858581
85MAP4K20.76226643
86PNCK0.76173417
87ERBB30.75895049
88LIMK10.75128868
89PRKCG0.73555474
90BRAF0.72995619
91PIK3CG0.72259617
92MAP2K20.70969222
93PIK3CA0.70022485
94MAP3K20.67363808
95PAK30.66867472
96PINK10.64859589
97STK240.63246796
98CDK60.62784581
99VRK20.62548798
100PAK10.62333250
101ZAP700.61902999
102PRKAA20.61695623
103CDK40.61682713
104LATS10.61045856
105NUAK10.59928603
106VRK10.59911973
107PRKACG0.59202905
108MAPKAPK20.58966260
109SCYL20.58430915
110MATK0.57693658
111NLK0.54687534
112MAP3K50.54508385
113LATS20.53944342
114DYRK30.53565880
115GRK10.53480603
116EEF2K0.52707346
117PLK20.52097360
118IGF1R0.51998379
119TEC0.51201624
120STK30.50889085
121WNK40.50794784
122MELK0.48912468
123ILK0.48050188
124CHEK20.47613707
125RPS6KA60.47263844
126PTK60.47177119
127CDK80.47170796
128RPS6KC10.46237718
129RPS6KL10.46237718
130FGFR10.46215692
131DAPK30.45454046
132ATR0.44898870
133CAMK2D0.44608091
134MKNK20.44595942
135CAMK2G0.43412448
136PDGFRA0.42100526
137PRKCA0.41283065
138PLK30.39620371
139ADRBK10.38217453
140CSNK1A10.37316341
141GRK60.37161061
142CSNK2A10.36728597
143TAOK10.35791344
144PRKCD0.35468202
145AKT30.34902345
146PDK30.32987027
147PDK40.32987027
148IKBKE0.32644730
149ERBB20.32445356
150TGFBR10.32313434
151TYK20.32105704
152BMX0.31178186
153GRK70.29608604
154RIPK10.28447061
155CSNK1G10.28097386
156PRKACA0.27996592
157CSNK2A20.27325014

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.44274752
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.00379013
3Proteasome_Homo sapiens_hsa030503.97774116
4Caffeine metabolism_Homo sapiens_hsa002323.64293921
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.38094162
6DNA replication_Homo sapiens_hsa030303.04912192
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.79330138
8Drug metabolism - other enzymes_Homo sapiens_hsa009832.63189834
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.46660504
10Mismatch repair_Homo sapiens_hsa034302.44346453
11Complement and coagulation cascades_Homo sapiens_hsa046102.39388842
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24658321
13Glutathione metabolism_Homo sapiens_hsa004802.21546227
14RNA polymerase_Homo sapiens_hsa030202.19435833
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.13122590
16Fatty acid degradation_Homo sapiens_hsa000712.06561212
17Base excision repair_Homo sapiens_hsa034102.06027296
18Butanoate metabolism_Homo sapiens_hsa006502.04135780
19Tryptophan metabolism_Homo sapiens_hsa003802.01533409
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.00809941
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00659236
22Homologous recombination_Homo sapiens_hsa034401.96859603
23Starch and sucrose metabolism_Homo sapiens_hsa005001.91896932
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85739518
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83454873
26Arginine biosynthesis_Homo sapiens_hsa002201.83346907
27Arachidonic acid metabolism_Homo sapiens_hsa005901.82871318
28Phenylalanine metabolism_Homo sapiens_hsa003601.78281429
29p53 signaling pathway_Homo sapiens_hsa041151.78111981
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78001755
31Sphingolipid metabolism_Homo sapiens_hsa006001.73216592
32Nucleotide excision repair_Homo sapiens_hsa034201.68113147
33RNA transport_Homo sapiens_hsa030131.62657400
34Pyrimidine metabolism_Homo sapiens_hsa002401.60427996
35Spliceosome_Homo sapiens_hsa030401.59455884
36Tyrosine metabolism_Homo sapiens_hsa003501.57016639
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54193484
38Legionellosis_Homo sapiens_hsa051341.52911697
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51152919
40Bile secretion_Homo sapiens_hsa049761.48753091
41Cell cycle_Homo sapiens_hsa041101.44819082
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44313005
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41905254
44Peroxisome_Homo sapiens_hsa041461.39549422
45Propanoate metabolism_Homo sapiens_hsa006401.38006928
46PPAR signaling pathway_Homo sapiens_hsa033201.37221728
47Folate biosynthesis_Homo sapiens_hsa007901.33656430
48Pyruvate metabolism_Homo sapiens_hsa006201.33647974
49Other glycan degradation_Homo sapiens_hsa005111.32503997
50beta-Alanine metabolism_Homo sapiens_hsa004101.32424106
51Vitamin B6 metabolism_Homo sapiens_hsa007501.32262118
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.27525275
53Fanconi anemia pathway_Homo sapiens_hsa034601.27170481
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.23372043
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21429504
56Collecting duct acid secretion_Homo sapiens_hsa049661.19857289
57Pentose phosphate pathway_Homo sapiens_hsa000301.18204561
58Sulfur metabolism_Homo sapiens_hsa009201.17048534
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16802388
60Linoleic acid metabolism_Homo sapiens_hsa005911.16442269
61Leishmaniasis_Homo sapiens_hsa051401.15379099
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14174092
63Arginine and proline metabolism_Homo sapiens_hsa003301.13512139
64Lysosome_Homo sapiens_hsa041421.13130661
65Renin-angiotensin system_Homo sapiens_hsa046141.11441289
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09227146
67Leukocyte transendothelial migration_Homo sapiens_hsa046701.03389024
68NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02010182
69Fatty acid metabolism_Homo sapiens_hsa012121.01258718
70Vitamin digestion and absorption_Homo sapiens_hsa049771.01025367
71Epstein-Barr virus infection_Homo sapiens_hsa051690.99636726
72One carbon pool by folate_Homo sapiens_hsa006700.99137307
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.99046405
74Carbon metabolism_Homo sapiens_hsa012000.97231343
75Mineral absorption_Homo sapiens_hsa049780.97213902
76Fat digestion and absorption_Homo sapiens_hsa049750.96844709
77Chemical carcinogenesis_Homo sapiens_hsa052040.96809890
78Fructose and mannose metabolism_Homo sapiens_hsa000510.95650015
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94190174
80Apoptosis_Homo sapiens_hsa042100.92591625
81Pertussis_Homo sapiens_hsa051330.90541080
82Shigellosis_Homo sapiens_hsa051310.86244940
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86159274
84Biosynthesis of amino acids_Homo sapiens_hsa012300.85890638
85Herpes simplex infection_Homo sapiens_hsa051680.83998678
86Antigen processing and presentation_Homo sapiens_hsa046120.81214285
87Phagosome_Homo sapiens_hsa041450.80514863
88Basal transcription factors_Homo sapiens_hsa030220.80375617
89Glycerolipid metabolism_Homo sapiens_hsa005610.80117775
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79882363
91Fatty acid elongation_Homo sapiens_hsa000620.79592971
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75958576
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75008715
94Selenocompound metabolism_Homo sapiens_hsa004500.74456249
95Galactose metabolism_Homo sapiens_hsa000520.74106635
96Non-homologous end-joining_Homo sapiens_hsa034500.74057919
97ABC transporters_Homo sapiens_hsa020100.73810010
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.73424264
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71296797
100Salmonella infection_Homo sapiens_hsa051320.71213350
101Tuberculosis_Homo sapiens_hsa051520.71173005
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70193803
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70052557
104Histidine metabolism_Homo sapiens_hsa003400.67434843
105Oxidative phosphorylation_Homo sapiens_hsa001900.66596236
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66368999
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65936898
108Influenza A_Homo sapiens_hsa051640.65270524
109Metabolic pathways_Homo sapiens_hsa011000.64178757
110RNA degradation_Homo sapiens_hsa030180.61959276
111Tight junction_Homo sapiens_hsa045300.61337725
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60835851
113Small cell lung cancer_Homo sapiens_hsa052220.59125134
114Protein digestion and absorption_Homo sapiens_hsa049740.57257753
115Asthma_Homo sapiens_hsa053100.56650511
116Adherens junction_Homo sapiens_hsa045200.56413952
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55847474
118Thyroid cancer_Homo sapiens_hsa052160.55249721
119Retinol metabolism_Homo sapiens_hsa008300.54364414
120Malaria_Homo sapiens_hsa051440.54281910
121Steroid biosynthesis_Homo sapiens_hsa001000.53141826
122Viral carcinogenesis_Homo sapiens_hsa052030.50958727
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50253092
124Protein export_Homo sapiens_hsa030600.48966005
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46890175
126Osteoclast differentiation_Homo sapiens_hsa043800.46446156
127MicroRNAs in cancer_Homo sapiens_hsa052060.45243846
128Purine metabolism_Homo sapiens_hsa002300.44461019
129Sulfur relay system_Homo sapiens_hsa041220.44387921
130Hepatitis C_Homo sapiens_hsa051600.43665360
131Rheumatoid arthritis_Homo sapiens_hsa053230.43214681
132Toxoplasmosis_Homo sapiens_hsa051450.42710103
133TNF signaling pathway_Homo sapiens_hsa046680.41925364
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41493097
135Staphylococcus aureus infection_Homo sapiens_hsa051500.41345948
136Hematopoietic cell lineage_Homo sapiens_hsa046400.40754772
137Ether lipid metabolism_Homo sapiens_hsa005650.40163816
138Systemic lupus erythematosus_Homo sapiens_hsa053220.39958982
139Bladder cancer_Homo sapiens_hsa052190.39431518
140Graft-versus-host disease_Homo sapiens_hsa053320.39345223
141Measles_Homo sapiens_hsa051620.38199629
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37586285
143Lysine degradation_Homo sapiens_hsa003100.36690342
144Intestinal immune network for IgA production_Homo sapiens_hsa046720.36638505
145TGF-beta signaling pathway_Homo sapiens_hsa043500.36633259
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36402479
147HTLV-I infection_Homo sapiens_hsa051660.36367763
148Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34169602
149Huntingtons disease_Homo sapiens_hsa050160.33029216
150Pancreatic secretion_Homo sapiens_hsa049720.19353059
151Nitrogen metabolism_Homo sapiens_hsa009100.14237029
152Parkinsons disease_Homo sapiens_hsa050120.12807502
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.12308545
154Prion diseases_Homo sapiens_hsa050200.11427461
155N-Glycan biosynthesis_Homo sapiens_hsa005100.09262603
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09036935
157Fatty acid biosynthesis_Homo sapiens_hsa000610.04359116
158Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.02543664
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01518943
160Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0679417
161Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0651443
162Glucagon signaling pathway_Homo sapiens_hsa04922-0.0401275
163Alzheimers disease_Homo sapiens_hsa05010-0.0296062
164Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0232930

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