PTGR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine catabolic process (GO:0006554)5.71827872
2lysine metabolic process (GO:0006553)5.71827872
3tricarboxylic acid cycle (GO:0006099)5.29170043
4fatty acid beta-oxidation (GO:0006635)5.26705893
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.10224859
6L-phenylalanine catabolic process (GO:0006559)5.10224859
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.97272033
8L-phenylalanine metabolic process (GO:0006558)4.97272033
9carnitine shuttle (GO:0006853)4.88123937
10fatty acid transmembrane transport (GO:1902001)4.85322013
11fatty acid oxidation (GO:0019395)4.77072158
12aspartate family amino acid catabolic process (GO:0009068)4.72882758
132-oxoglutarate metabolic process (GO:0006103)4.72044821
14lipid oxidation (GO:0034440)4.71165596
15fatty acid catabolic process (GO:0009062)4.66562289
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.61945517
17regulation of sequestering of triglyceride (GO:0010889)4.60423668
18short-chain fatty acid metabolic process (GO:0046459)4.60201049
19alpha-linolenic acid metabolic process (GO:0036109)4.57607750
20acetyl-CoA metabolic process (GO:0006084)4.57060412
21branched-chain amino acid catabolic process (GO:0009083)4.55336355
22glyoxylate metabolic process (GO:0046487)4.52684459
23behavioral response to nicotine (GO:0035095)4.42635619
24valine metabolic process (GO:0006573)4.37479639
25aromatic amino acid family catabolic process (GO:0009074)4.29202509
26branched-chain amino acid metabolic process (GO:0009081)4.28312133
27monocarboxylic acid catabolic process (GO:0072329)4.22256943
28cellular ketone body metabolic process (GO:0046950)4.21807355
29amino-acid betaine metabolic process (GO:0006577)4.18986622
30water-soluble vitamin biosynthetic process (GO:0042364)4.17279901
31tricarboxylic acid metabolic process (GO:0072350)4.17121132
32succinate metabolic process (GO:0006105)4.11888531
33regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.11609429
34NADH metabolic process (GO:0006734)4.10037912
35biotin metabolic process (GO:0006768)4.04069343
36carnitine metabolic process (GO:0009437)4.00042275
37regulation of triglyceride catabolic process (GO:0010896)3.98962112
38carnitine transmembrane transport (GO:1902603)3.96535022
39amino-acid betaine transport (GO:0015838)3.95330706
40carnitine transport (GO:0015879)3.95330706
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95116156
42response to pheromone (GO:0019236)3.93905372
43kynurenine metabolic process (GO:0070189)3.87648544
44regulation of fatty acid oxidation (GO:0046320)3.84381296
45cysteine metabolic process (GO:0006534)3.75064800
46respiratory chain complex IV assembly (GO:0008535)3.74342617
47positive regulation of fatty acid oxidation (GO:0046321)3.70139474
48sulfur amino acid catabolic process (GO:0000098)3.69819833
49ketone body metabolic process (GO:1902224)3.68716887
50regulation of acyl-CoA biosynthetic process (GO:0050812)3.66595076
51ethanol oxidation (GO:0006069)3.64517731
52tryptophan catabolic process (GO:0006569)3.63298979
53indole-containing compound catabolic process (GO:0042436)3.63298979
54indolalkylamine catabolic process (GO:0046218)3.63298979
55bile acid biosynthetic process (GO:0006699)3.63019120
56fucose catabolic process (GO:0019317)3.61379533
57L-fucose metabolic process (GO:0042354)3.61379533
58L-fucose catabolic process (GO:0042355)3.61379533
59positive regulation of fatty acid beta-oxidation (GO:0032000)3.60301238
60oxaloacetate metabolic process (GO:0006107)3.58487940
61organic acid catabolic process (GO:0016054)3.56825382
62carboxylic acid catabolic process (GO:0046395)3.56825382
63alpha-amino acid catabolic process (GO:1901606)3.52661617
64acyl-CoA biosynthetic process (GO:0071616)3.50570328
65thioester biosynthetic process (GO:0035384)3.50570328
66cytochrome complex assembly (GO:0017004)3.50207480
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.49716228
68tryptophan metabolic process (GO:0006568)3.47719194
69quaternary ammonium group transport (GO:0015697)3.44624703
70thioester metabolic process (GO:0035383)3.43812908
71acyl-CoA metabolic process (GO:0006637)3.43812908
72cellular amino acid catabolic process (GO:0009063)3.43784375
73protein complex biogenesis (GO:0070271)3.43615440
74indolalkylamine metabolic process (GO:0006586)3.43551759
75homocysteine metabolic process (GO:0050667)3.38774035
76coenzyme catabolic process (GO:0009109)3.35709479
77negative regulation of cytosolic calcium ion concentration (GO:0051481)3.33311613
78regulation of cofactor metabolic process (GO:0051193)3.32430776
79regulation of coenzyme metabolic process (GO:0051196)3.32430776
80phospholipid homeostasis (GO:0055091)3.31539999
81fatty acid homeostasis (GO:0055089)3.23267172
82acylglycerol homeostasis (GO:0055090)3.21206862
83triglyceride homeostasis (GO:0070328)3.21206862
84regulation of cholesterol metabolic process (GO:0090181)3.20907264
85sarcomere organization (GO:0045214)3.20394451
86mitochondrial respiratory chain complex assembly (GO:0033108)3.19515997
87dicarboxylic acid biosynthetic process (GO:0043650)3.18846976
88glutamate metabolic process (GO:0006536)3.16225709
89drug transmembrane transport (GO:0006855)3.16112207
90signal peptide processing (GO:0006465)3.14329321
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14204193
92bile acid metabolic process (GO:0008206)3.14198169
93plasma lipoprotein particle clearance (GO:0034381)3.13157029
94aromatic amino acid family metabolic process (GO:0009072)3.12693903
95regulation of hexokinase activity (GO:1903299)3.11016332
96regulation of glucokinase activity (GO:0033131)3.11016332
97serine family amino acid catabolic process (GO:0009071)3.10826318
98epithelial cilium movement (GO:0003351)3.10296522
99complement activation, alternative pathway (GO:0006957)3.08757709
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.08652819
101mitochondrial respiratory chain complex I assembly (GO:0032981)3.08652819
102NADH dehydrogenase complex assembly (GO:0010257)3.08652819
103urea metabolic process (GO:0019627)3.08028331
104urea cycle (GO:0000050)3.08028331
105positive regulation of lipid catabolic process (GO:0050996)3.06524375
106nonmotile primary cilium assembly (GO:0035058)3.05030220
107response to mercury ion (GO:0046689)3.02795476
108cellular modified amino acid catabolic process (GO:0042219)3.02605038
109negative regulation of fatty acid biosynthetic process (GO:0045717)3.01396998
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00835725
111small molecule catabolic process (GO:0044282)2.98106353
112peptidyl-glutamic acid carboxylation (GO:0017187)2.96758963
113protein carboxylation (GO:0018214)2.96758963
114tyrosine metabolic process (GO:0006570)2.96396337
115regulation of fatty acid beta-oxidation (GO:0031998)2.95949139
116negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.94421414
117platelet dense granule organization (GO:0060155)2.94384700
118preassembly of GPI anchor in ER membrane (GO:0016254)2.93678501
119dicarboxylic acid catabolic process (GO:0043649)2.93647209
120cardiac myofibril assembly (GO:0055003)2.91969169
121nitrogen cycle metabolic process (GO:0071941)2.90328868
122negative regulation of telomere maintenance (GO:0032205)2.89074303
123triglyceride catabolic process (GO:0019433)2.86975296
124kidney morphogenesis (GO:0060993)2.86465338
125regulation of protein activation cascade (GO:2000257)2.85963475
126very long-chain fatty acid metabolic process (GO:0000038)2.84844220
127gamma-aminobutyric acid transport (GO:0015812)2.83747248
128creatine metabolic process (GO:0006600)2.83070899
129detection of light stimulus involved in visual perception (GO:0050908)2.82282340
130detection of light stimulus involved in sensory perception (GO:0050962)2.82282340
131DNA deamination (GO:0045006)2.81596404
132axoneme assembly (GO:0035082)2.80979043
133regulation of cilium movement (GO:0003352)2.80738858
134amino acid salvage (GO:0043102)2.79777580
135L-methionine salvage (GO:0071267)2.79777580
136L-methionine biosynthetic process (GO:0071265)2.79777580
137photoreceptor cell maintenance (GO:0045494)2.73039314
138cellular biogenic amine catabolic process (GO:0042402)2.72553068
139amine catabolic process (GO:0009310)2.72553068
140cilium organization (GO:0044782)2.71937948
141cilium movement (GO:0003341)2.68618322
142indole-containing compound metabolic process (GO:0042430)2.66093113
143ubiquinone biosynthetic process (GO:0006744)2.65068814
144cilium assembly (GO:0042384)2.64957487
145mannosylation (GO:0097502)2.63331891
146negative regulation of DNA-dependent DNA replication (GO:2000104)2.62885885
147DNA double-strand break processing (GO:0000729)2.62488861
148S-adenosylmethionine metabolic process (GO:0046500)2.61829972
149cilium morphogenesis (GO:0060271)2.61730638
150regulation of action potential (GO:0098900)2.59441523
151maturation of 5.8S rRNA (GO:0000460)2.58666473
152protein localization to cilium (GO:0061512)2.58579835
153reflex (GO:0060004)2.57802849
154methionine biosynthetic process (GO:0009086)2.57394093
155replication fork processing (GO:0031297)2.56975806
156protein-cofactor linkage (GO:0018065)2.55897943
157dopamine transport (GO:0015872)2.55055619
158intraciliary transport (GO:0042073)2.53817200
159ubiquinone metabolic process (GO:0006743)2.50506819
160piRNA metabolic process (GO:0034587)2.48930445
161mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.48642027
162retinal cone cell development (GO:0046549)2.48489739
163drug catabolic process (GO:0042737)2.47939784
164neural tube formation (GO:0001841)2.45850160
165oxidative demethylation (GO:0070989)2.45217967
166protein K6-linked ubiquitination (GO:0085020)2.44443746
167exogenous drug catabolic process (GO:0042738)2.44169793
168nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.41921386
169neuronal action potential (GO:0019228)2.41839400
170reciprocal meiotic recombination (GO:0007131)2.40500747
171reciprocal DNA recombination (GO:0035825)2.40500747
172exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39973755
173benzene-containing compound metabolic process (GO:0042537)2.38799552
174recombinational repair (GO:0000725)2.38736801
175primary amino compound metabolic process (GO:1901160)2.37509070
176inositol phosphate catabolic process (GO:0071545)2.37357847
177RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.37348619
178synapsis (GO:0007129)2.37092342
179regulation of translation, ncRNA-mediated (GO:0045974)2.36966446
180negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.36966446
181negative regulation of translation, ncRNA-mediated (GO:0040033)2.36966446
182C4-dicarboxylate transport (GO:0015740)2.36516166
183photoreceptor cell development (GO:0042461)2.36411507
184double-strand break repair via homologous recombination (GO:0000724)2.36353084
185protein polyglutamylation (GO:0018095)2.35685516
186auditory receptor cell stereocilium organization (GO:0060088)2.34950698
187cilium or flagellum-dependent cell motility (GO:0001539)2.33990639
188sulfation (GO:0051923)2.31848249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.53877982
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.06209489
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.00896518
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.30394239
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.91671718
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.10578071
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.04583480
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.92984710
9ZNF274_21170338_ChIP-Seq_K562_Hela3.62443840
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.41276807
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.30158322
12VDR_22108803_ChIP-Seq_LS180_Human3.27657438
13GBX2_23144817_ChIP-Seq_PC3_Human2.92943784
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85629778
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59347012
16IGF1R_20145208_ChIP-Seq_DFB_Human2.54729308
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.52277164
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49295604
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.46162051
20CLOCK_20551151_ChIP-Seq_293T_Human2.33556472
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.30900736
22TAF15_26573619_Chip-Seq_HEK293_Human2.29766498
23FUS_26573619_Chip-Seq_HEK293_Human2.24192690
24EWS_26573619_Chip-Seq_HEK293_Human2.19754430
25EZH2_22144423_ChIP-Seq_EOC_Human2.18258967
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17945982
27GATA1_22025678_ChIP-Seq_K562_Human2.11304887
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.05922007
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05362338
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02637632
31P300_19829295_ChIP-Seq_ESCs_Human2.01528732
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95170724
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.85788785
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83641953
35ER_23166858_ChIP-Seq_MCF-7_Human1.83366475
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83218050
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81085973
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77598333
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.77586418
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.77586418
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75092039
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72253195
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71964292
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.69381172
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64868097
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64272273
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.61699268
48SMAD4_21799915_ChIP-Seq_A2780_Human1.57200101
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.55086574
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54695812
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50713724
52CBP_20019798_ChIP-Seq_JUKART_Human1.50556547
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50556547
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.49918483
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.49647556
56* STAT3_23295773_ChIP-Seq_U87_Human1.49543545
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49433289
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47679947
59TP53_22573176_ChIP-Seq_HFKS_Human1.45598747
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44070384
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43361368
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42192116
63AR_25329375_ChIP-Seq_VCAP_Human1.41724630
64NANOG_19829295_ChIP-Seq_ESCs_Human1.39319369
65SOX2_19829295_ChIP-Seq_ESCs_Human1.39319369
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.38119367
67TCF4_23295773_ChIP-Seq_U87_Human1.36811066
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36406042
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35013957
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34808617
71TCF4_22108803_ChIP-Seq_LS180_Human1.33238037
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32530460
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31774057
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.31603672
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31598036
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31300971
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30013156
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29382168
79MYC_18940864_ChIP-ChIP_HL60_Human1.29295036
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29240846
81IRF1_19129219_ChIP-ChIP_H3396_Human1.29107948
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29089244
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.29089244
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28859678
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.26900544
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.26365420
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25368614
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24596242
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23575269
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23025085
91RUNX2_22187159_ChIP-Seq_PCA_Human1.21297256
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21157860
93ELK1_19687146_ChIP-ChIP_HELA_Human1.19939948
94RNF2_27304074_Chip-Seq_NSC_Mouse1.18546501
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.18439116
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18423417
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16735331
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16383374
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16383374
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15146325
101REST_21632747_ChIP-Seq_MESCs_Mouse1.14690657
102* HNF4A_19822575_ChIP-Seq_HepG2_Human1.14125933
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.13590862
104HOXB7_26014856_ChIP-Seq_BT474_Human1.12043691
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.11297763
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11287738
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.10573551
108NCOR_22424771_ChIP-Seq_293T_Human1.09053771
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.08570668
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08455129
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08029261
112GATA3_21878914_ChIP-Seq_MCF-7_Human1.07446386
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07004928
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.06328986
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06122385
116HTT_18923047_ChIP-ChIP_STHdh_Human1.05720446
117P53_22387025_ChIP-Seq_ESCs_Mouse1.05281426
118ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03746084
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03582465
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01700382
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01646280
122AR_21572438_ChIP-Seq_LNCaP_Human0.99215810
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99100841
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.99033858
125* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98859511
126* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98859511
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.98551944
128TRIM28_21343339_ChIP-Seq_HEK293_Human0.96921552
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96897465
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95588061
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93432500
132ZNF263_19887448_ChIP-Seq_K562_Human0.93068772
133GATA1_19941826_ChIP-Seq_K562_Human0.91479209
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87886390
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87712380
136GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87289620
137* GATA2_21666600_ChIP-Seq_HMVEC_Human0.86710607
138MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86148641
139* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84426352
140GATA2_19941826_ChIP-Seq_K562_Human0.83823933
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83422148
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82278845
143IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81955007
144* GATA4_25053715_ChIP-Seq_YYC3_Human0.81663850
145Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81018196
146AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80801249
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79693526
148STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78888066
149NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77852013
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77390991
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76837060
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74991295
153CBP_21632823_ChIP-Seq_H3396_Human0.73255238
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.73207251
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.72728925
156PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71839059
157SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69911847
158ERG_20517297_ChIP-Seq_VCAP_Human0.69314208
159FOXO3_23340844_ChIP-Seq_DLD1_Human0.68540390
160IRF8_22096565_ChIP-ChIP_GC-B_Human0.67684481
161FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66212921
162EGR1_19032775_ChIP-ChIP_M12_Human0.65776298
163RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65609398
164NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.65394914
165CEBPB_22108803_ChIP-Seq_LS180_Human0.64166033
166AR_20517297_ChIP-Seq_VCAP_Human0.63561231
167RXRA_24833708_ChIP-Seq_LIVER_Mouse0.62484767
168FOXA1_25552417_ChIP-Seq_VCAP_Human0.61765485
169BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60416938
170FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.60286742
171BCAT_22108803_ChIP-Seq_LS180_Human0.59943326
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.55622311
173RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.55469300
174ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55437198
175SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.54547154
176SRF_21415370_ChIP-Seq_HL-1_Mouse0.54528728
177GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.53917309
178TAF2_19829295_ChIP-Seq_ESCs_Human0.52793147
179* GATA3_24758297_ChIP-Seq_MCF-7_Human0.52555030
180FOXH1_21741376_ChIP-Seq_ESCs_Human0.52549845
181CDX2_22108803_ChIP-Seq_LS180_Human0.52531710
182SOX2_20726797_ChIP-Seq_SW620_Human0.52310156
183ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.52266888
184GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.51394372
185BP1_19119308_ChIP-ChIP_Hs578T_Human0.51073641
186ESET_19884257_ChIP-Seq_ESCs_Mouse0.50170565
187OCT4_20526341_ChIP-Seq_ESCs_Human0.50043808
188TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.49555227
189GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.49316635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.03422934
2MP0005360_urolithiasis4.72233177
3MP0002837_dystrophic_cardiac_calcinosis4.34490660
4MP0005085_abnormal_gallbladder_physiolo4.04869921
5MP0005365_abnormal_bile_salt3.91357088
6MP0003806_abnormal_nucleotide_metabolis3.25368786
7MP0003646_muscle_fatigue3.18603632
8MP0008875_abnormal_xenobiotic_pharmacok3.01771310
9MP0004130_abnormal_muscle_cell2.86843228
10MP0005670_abnormal_white_adipose2.74296132
11MP0004084_abnormal_cardiac_muscle2.71982986
12MP0008877_abnormal_DNA_methylation2.65610656
13MP0010329_abnormal_lipoprotein_level2.61407393
14MP0005332_abnormal_amino_acid2.59517846
15MP0003195_calcinosis2.58797086
16MP0003252_abnormal_bile_duct2.56187231
17MP0004215_abnormal_myocardial_fiber2.49795295
18MP0005330_cardiomyopathy2.37406129
19MP0004036_abnormal_muscle_relaxation2.35914713
20MP0005551_abnormal_eye_electrophysiolog2.32223140
21MP0000751_myopathy2.29095816
22MP0006036_abnormal_mitochondrial_physio2.23126277
23MP0006072_abnormal_retinal_apoptosis2.15210000
24MP0005666_abnormal_adipose_tissue2.10789342
25MP0000749_muscle_degeneration2.07555052
26MP0009840_abnormal_foam_cell2.07468217
27MP0003136_yellow_coat_color1.98071059
28MP0002118_abnormal_lipid_homeostasis1.97729502
29MP0002102_abnormal_ear_morphology1.96989166
30MP0002638_abnormal_pupillary_reflex1.96886828
31MP0009046_muscle_twitch1.94196769
32MP0002938_white_spotting1.88313455
33MP0004142_abnormal_muscle_tone1.88075569
34MP0005645_abnormal_hypothalamus_physiol1.84035855
35MP0003191_abnormal_cellular_cholesterol1.83800809
36MP0005646_abnormal_pituitary_gland1.83206852
37MP0005253_abnormal_eye_physiology1.82560419
38MP0000569_abnormal_digit_pigmentation1.80891546
39MP0000372_irregular_coat_pigmentation1.78459082
40MP0004043_abnormal_pH_regulation1.78087380
41MP0001485_abnormal_pinna_reflex1.77235274
42MP0002972_abnormal_cardiac_muscle1.74812336
43MP0008775_abnormal_heart_ventricle1.73397850
44MP0001968_abnormal_touch/_nociception1.73346250
45MP0001666_abnormal_nutrient_absorption1.70487101
46MP0006292_abnormal_olfactory_placode1.69805180
47MP0005584_abnormal_enzyme/coenzyme_acti1.68016991
48MP0005083_abnormal_biliary_tract1.66827926
49MP0005319_abnormal_enzyme/_coenzyme1.65584812
50MP0006276_abnormal_autonomic_nervous1.64882397
51MP0004087_abnormal_muscle_fiber1.61449357
52MP0002971_abnormal_brown_adipose1.60177372
53MP0003186_abnormal_redox_activity1.58201012
54MP0001984_abnormal_olfaction1.57236637
55MP0000609_abnormal_liver_physiology1.56210008
56MP0004885_abnormal_endolymph1.55640133
57MP0009745_abnormal_behavioral_response1.55410180
58MP0008872_abnormal_physiological_respon1.54012420
59MP0005620_abnormal_muscle_contractility1.53656871
60MP0003011_delayed_dark_adaptation1.51794327
61MP0000427_abnormal_hair_cycle1.51745318
62MP0009643_abnormal_urine_homeostasis1.50759731
63MP0001544_abnormal_cardiovascular_syste1.48112405
64MP0005385_cardiovascular_system_phenoty1.48112405
65MP0002272_abnormal_nervous_system1.46618675
66MP0002736_abnormal_nociception_after1.46179955
67MP0003787_abnormal_imprinting1.44650054
68MP0004185_abnormal_adipocyte_glucose1.42656230
69MP0002269_muscular_atrophy1.42144279
70MP0000631_abnormal_neuroendocrine_gland1.41070862
71MP0003137_abnormal_impulse_conducting1.38937810
72MP0005084_abnormal_gallbladder_morpholo1.38703322
73MP0005379_endocrine/exocrine_gland_phen1.37862075
74MP0003718_maternal_effect1.37244514
75MP0005375_adipose_tissue_phenotype1.34827453
76MP0004133_heterotaxia1.34683532
77MP0004019_abnormal_vitamin_homeostasis1.34302163
78MP0005535_abnormal_body_temperature1.31588964
79MP0001486_abnormal_startle_reflex1.29723415
80MP0006035_abnormal_mitochondrial_morpho1.29201461
81MP0010630_abnormal_cardiac_muscle1.28022206
82MP0000747_muscle_weakness1.26579898
83MP0003690_abnormal_glial_cell1.25876053
84MP0001764_abnormal_homeostasis1.24032309
85MP0001501_abnormal_sleep_pattern1.23830994
86MP0006138_congestive_heart_failure1.23815548
87MP0002138_abnormal_hepatobiliary_system1.22394828
88MP0004484_altered_response_of1.20581765
89MP0001529_abnormal_vocalization1.20320007
90MP0003880_abnormal_central_pattern1.20143618
91MP0008058_abnormal_DNA_repair1.19976879
92MP0002078_abnormal_glucose_homeostasis1.19259948
93MP0003221_abnormal_cardiomyocyte_apopto1.17793494
94MP0002163_abnormal_gland_morphology1.17730617
95MP0002557_abnormal_social/conspecific_i1.14827713
96MP0002572_abnormal_emotion/affect_behav1.12512070
97MP0003122_maternal_imprinting1.09356330
98MP0003283_abnormal_digestive_organ1.09091217
99MP0003656_abnormal_erythrocyte_physiolo1.07824445
100MP0005389_reproductive_system_phenotype1.07519889
101MP0002106_abnormal_muscle_physiology1.07389497
102MP0002064_seizures1.07263283
103MP0000750_abnormal_muscle_regeneration1.07075482
104MP0005386_behavior/neurological_phenoty1.05425298
105MP0004924_abnormal_behavior1.05425298
106MP0009780_abnormal_chondrocyte_physiolo1.05049349
107MP0005058_abnormal_lysosome_morphology1.04676124
108MP0002160_abnormal_reproductive_system1.04107631
109MP0004147_increased_porphyrin_level1.03784353
110MP0005334_abnormal_fat_pad1.03596580
111MP0005451_abnormal_body_composition1.02974754
112MP0002653_abnormal_ependyma_morphology1.01882208
113MP0004085_abnormal_heartbeat1.01242601
114MP0002332_abnormal_exercise_endurance0.99890889
115MP0003950_abnormal_plasma_membrane0.99188021
116MP0001986_abnormal_taste_sensitivity0.98803473
117MP0000230_abnormal_systemic_arterial0.98282470
118MP0002234_abnormal_pharynx_morphology0.97970876
119MP0005174_abnormal_tail_pigmentation0.97290986
120MP0003724_increased_susceptibility_to0.96063039
121MP0002254_reproductive_system_inflammat0.95760310
122MP0005266_abnormal_metabolism0.95657487
123MP0001919_abnormal_reproductive_system0.95398436
124MP0001661_extended_life_span0.95302239
125MP0003121_genomic_imprinting0.94091116
126MP0005410_abnormal_fertilization0.92350992
127MP0005075_abnormal_melanosome_morpholog0.91347317
128MP0002928_abnormal_bile_duct0.91166662
129MP0000013_abnormal_adipose_tissue0.90045578
130MP0000383_abnormal_hair_follicle0.89697518
131MP0005195_abnormal_posterior_eye0.89648205
132MP0010386_abnormal_urinary_bladder0.89146688
133MP0005165_increased_susceptibility_to0.89035036
134MP0005636_abnormal_mineral_homeostasis0.88383481
135MP0001756_abnormal_urination0.88048980
136MP0002067_abnormal_sensory_capabilities0.88017356
137MP0001970_abnormal_pain_threshold0.87054359
138MP0000759_abnormal_skeletal_muscle0.86907552
139MP0003868_abnormal_feces_composition0.85205633
140MP0000647_abnormal_sebaceous_gland0.84832368
141MP0002693_abnormal_pancreas_physiology0.83881291
142MP0003698_abnormal_male_reproductive0.83841617
143MP0001944_abnormal_pancreas_morphology0.83769195
144MP0005369_muscle_phenotype0.83480068
145MP0000003_abnormal_adipose_tissue0.82468521
146MP0002734_abnormal_mechanical_nocicepti0.81807571
147MP0002733_abnormal_thermal_nociception0.81152534
148MP0000343_altered_response_to0.80423318
149MP0001929_abnormal_gametogenesis0.79463306
150MP0001324_abnormal_eye_pigmentation0.78670448
151MP0002876_abnormal_thyroid_physiology0.78422870
152MP0002735_abnormal_chemical_nociception0.78159924
153MP0003828_pulmonary_edema0.77782335
154MP0002063_abnormal_learning/memory/cond0.77396382
155MP0008789_abnormal_olfactory_epithelium0.75872719
156MP0010368_abnormal_lymphatic_system0.74827046
157MP0005448_abnormal_energy_balance0.74514106
158MP0009115_abnormal_fat_cell0.74160682
159MP0005376_homeostasis/metabolism_phenot0.73713837
160MP0000604_amyloidosis0.73046671
161MP0009642_abnormal_blood_homeostasis0.73000128
162MP0000598_abnormal_liver_morphology0.72016042
163MP0009763_increased_sensitivity_to0.71540539
164MP0001765_abnormal_ion_homeostasis0.70395771
165MP0008438_abnormal_cutaneous_collagen0.67977190
166MP0004145_abnormal_muscle_electrophysio0.66702546
167MP0009697_abnormal_copulation0.66137639
168MP0004233_abnormal_muscle_weight0.65751742
169MP0003329_amyloid_beta_deposits0.64959999
170MP0009764_decreased_sensitivity_to0.63681581
171MP0008469_abnormal_protein_level0.62945825
172MP0002970_abnormal_white_adipose0.61530107
173MP0002909_abnormal_adrenal_gland0.59904288
174MP0002127_abnormal_cardiovascular_syste0.58956630

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.11467309
2Abnormality of fatty-acid metabolism (HP:0004359)4.55000719
3Myoglobinuria (HP:0002913)4.44696755
4Hyperglycinuria (HP:0003108)4.43563222
5Ketoacidosis (HP:0001993)4.40569446
6Ketosis (HP:0001946)4.32426278
7Pancreatic cysts (HP:0001737)4.26112651
8Hyperammonemia (HP:0001987)4.22745823
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.04593150
10Abnormality of glycine metabolism (HP:0010895)4.03168225
11Abnormality of serine family amino acid metabolism (HP:0010894)4.03168225
12Dicarboxylic aciduria (HP:0003215)4.00226937
13Abnormality of dicarboxylic acid metabolism (HP:0010995)4.00226937
14Pancreatic fibrosis (HP:0100732)3.98893930
15True hermaphroditism (HP:0010459)3.85278380
16Intrahepatic cholestasis (HP:0001406)3.81484641
17Molar tooth sign on MRI (HP:0002419)3.79707174
18Abnormality of midbrain morphology (HP:0002418)3.79707174
19Hepatic necrosis (HP:0002605)3.75748660
20Generalized aminoaciduria (HP:0002909)3.72286277
21Xanthomatosis (HP:0000991)3.68588307
22Sudden death (HP:0001699)3.63166744
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.56848574
24Exercise-induced myalgia (HP:0003738)3.53068920
25Cerebral edema (HP:0002181)3.42627873
26Nephronophthisis (HP:0000090)3.37956023
27Medial flaring of the eyebrow (HP:0010747)3.33477459
28Rhabdomyolysis (HP:0003201)3.33003248
29Hyperglycinemia (HP:0002154)3.32166028
30Hyperlipoproteinemia (HP:0010980)3.28263568
31Palpitations (HP:0001962)3.25380599
32Deep venous thrombosis (HP:0002625)3.25011970
33Calf muscle hypertrophy (HP:0008981)3.20361540
34Ventricular tachycardia (HP:0004756)3.19524309
35Congenital stationary night blindness (HP:0007642)3.13626998
36Exercise-induced muscle cramps (HP:0003710)3.10996125
37Acute encephalopathy (HP:0006846)3.09645721
38Increased muscle lipid content (HP:0009058)3.08735543
39Hypoalphalipoproteinemia (HP:0003233)3.06341654
40Abnormality of the renal cortex (HP:0011035)3.02734217
41Abnormality of the renal medulla (HP:0100957)2.99054481
42Metabolic acidosis (HP:0001942)2.97610133
43Lethargy (HP:0001254)2.95728470
44Proximal tubulopathy (HP:0000114)2.94856472
45Abnormal mitochondria in muscle tissue (HP:0008316)2.92971354
46Muscle hypertrophy of the lower extremities (HP:0008968)2.91851519
47Hepatocellular necrosis (HP:0001404)2.88727314
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.87627460
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.87239149
50Type II lissencephaly (HP:0007260)2.85613724
51Gait imbalance (HP:0002141)2.85336443
52Hypolipoproteinemia (HP:0010981)2.83243050
53Right ventricular cardiomyopathy (HP:0011663)2.82027810
54Hypobetalipoproteinemia (HP:0003563)2.79377626
55Lipoatrophy (HP:0100578)2.75098504
56Congenital primary aphakia (HP:0007707)2.74295762
57Atrial fibrillation (HP:0005110)2.73554887
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.73333974
59Abolished electroretinogram (ERG) (HP:0000550)2.73322214
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.73046609
61Hyperinsulinemic hypoglycemia (HP:0000825)2.69494174
62Dilated cardiomyopathy (HP:0001644)2.67213413
63Cystic liver disease (HP:0006706)2.66470354
64Acute necrotizing encephalopathy (HP:0006965)2.64339069
65Attenuation of retinal blood vessels (HP:0007843)2.63457256
66Hypoglycemic seizures (HP:0002173)2.63252756
67Muscle fiber splitting (HP:0003555)2.61464728
68Large for gestational age (HP:0001520)2.60849885
69Hyporeflexia of lower limbs (HP:0002600)2.59134119
70Abnormality of serum amino acid levels (HP:0003112)2.58531149
71Nephrogenic diabetes insipidus (HP:0009806)2.58476922
72Hyperventilation (HP:0002883)2.58050134
73Vomiting (HP:0002013)2.57092309
74Complement deficiency (HP:0004431)2.56990330
75Nausea (HP:0002018)2.55529197
76Prolonged partial thromboplastin time (HP:0003645)2.55080721
77Pendular nystagmus (HP:0012043)2.54407953
78Abnormality of glycolysis (HP:0004366)2.53502254
79Increased serum pyruvate (HP:0003542)2.53502254
80Renal cortical cysts (HP:0000803)2.51067334
81Epidermoid cyst (HP:0200040)2.50010439
82Syncope (HP:0001279)2.48933885
83Asymmetric septal hypertrophy (HP:0001670)2.47682854
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46691890
85Abnormality of alanine metabolism (HP:0010916)2.46691890
86Hyperalaninemia (HP:0003348)2.46691890
87Lactic acidosis (HP:0003128)2.46366868
88Gout (HP:0001997)2.45932991
89Sclerocornea (HP:0000647)2.45834525
90Methylmalonic acidemia (HP:0002912)2.45818777
91Primary atrial arrhythmia (HP:0001692)2.45769417
92Tubular atrophy (HP:0000092)2.45029932
93Chronic hepatic failure (HP:0100626)2.43626560
94Ragged-red muscle fibers (HP:0003200)2.41791626
95Abnormality of purine metabolism (HP:0004352)2.40023804
96Increased intramyocellular lipid droplets (HP:0012240)2.39107130
97Abnormal drinking behavior (HP:0030082)2.38107978
98Polydipsia (HP:0001959)2.38107978
99Abnormality of urine glucose concentration (HP:0011016)2.38038338
100Glycosuria (HP:0003076)2.38038338
101Atrioventricular block (HP:0001678)2.34716911
102Supraventricular tachycardia (HP:0004755)2.33594284
103Increased CSF lactate (HP:0002490)2.31578489
104Abnormal rod and cone electroretinograms (HP:0008323)2.31040435
105Gaze-evoked nystagmus (HP:0000640)2.29851718
106Supraventricular arrhythmia (HP:0005115)2.28776332
107Delayed CNS myelination (HP:0002188)2.28594747
108Progressive macrocephaly (HP:0004481)2.28457103
109Abnormality of the calf musculature (HP:0001430)2.28190360
110Pheochromocytoma (HP:0002666)2.27776267
111Conjunctival hamartoma (HP:0100780)2.24887393
112Furrowed tongue (HP:0000221)2.23272438
113Heart block (HP:0012722)2.23235202
114Bundle branch block (HP:0011710)2.23033827
115Genital tract atresia (HP:0001827)2.22011507
116Mitochondrial inheritance (HP:0001427)2.18721792
117Intestinal atresia (HP:0011100)2.18713330
118Aplasia/Hypoplasia of the tongue (HP:0010295)2.18694825
119Vaginal atresia (HP:0000148)2.18570586
120Congenital hepatic fibrosis (HP:0002612)2.17993711
121Methylmalonic aciduria (HP:0012120)2.17722785
122Hyperbilirubinemia (HP:0002904)2.17398288
123Skin nodule (HP:0200036)2.16909286
124Abnormality of methionine metabolism (HP:0010901)2.16116657
125Congenital, generalized hypertrichosis (HP:0004540)2.15761142
126Hydroxyprolinuria (HP:0003080)2.14288500
127Abnormality of proline metabolism (HP:0010907)2.14288500
128Anencephaly (HP:0002323)2.13312188
129Hyperglycemia (HP:0003074)2.11841684
130Abnormality of sulfur amino acid metabolism (HP:0004339)2.11839847
131Poor coordination (HP:0002370)2.11467069
132Dynein arm defect of respiratory motile cilia (HP:0012255)2.11290194
133Absent/shortened dynein arms (HP:0200106)2.11290194
134Prolonged QT interval (HP:0001657)2.10343183
135Abnormality of the common coagulation pathway (HP:0010990)2.09217713
136Abnormality of the labia minora (HP:0012880)2.08342601
137Ventricular arrhythmia (HP:0004308)2.08305412
138Neuroendocrine neoplasm (HP:0100634)2.06673968
139Cholelithiasis (HP:0001081)2.05707313
140Abnormal gallbladder morphology (HP:0012437)2.05375112
141Late onset (HP:0003584)2.05355240
142Hyperuricemia (HP:0002149)2.05105924
143Increased purine levels (HP:0004368)2.05105924
144Postaxial foot polydactyly (HP:0001830)2.03704437
145Increased corneal curvature (HP:0100692)2.03535695
146Keratoconus (HP:0000563)2.03535695
147Cerebellar dysplasia (HP:0007033)2.02499636
148Hypothermia (HP:0002045)2.01989659
149Abnormality of the pons (HP:0007361)2.00977995
150Inability to walk (HP:0002540)2.00778162
151Broad-based gait (HP:0002136)2.00470911
152Hemiparesis (HP:0001269)1.99754760
153Progressive inability to walk (HP:0002505)1.97228951
154Male pseudohermaphroditism (HP:0000037)1.96263644
155Decreased central vision (HP:0007663)1.95377440
156Abnormal respiratory epithelium morphology (HP:0012253)1.92462664
157Abnormal respiratory motile cilium morphology (HP:0005938)1.92462664
158Lipid accumulation in hepatocytes (HP:0006561)1.92305939
159Lissencephaly (HP:0001339)1.90634381
160Polyuria (HP:0000103)1.88106365
161Concave nail (HP:0001598)1.87500926
162Fair hair (HP:0002286)1.86416156
163Bile duct proliferation (HP:0001408)1.86033050
164Abnormal biliary tract physiology (HP:0012439)1.86033050
165Decreased circulating renin level (HP:0003351)1.85765823
166Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84582584
167Hypoplasia of the pons (HP:0012110)1.84237983
168Increased hepatocellular lipid droplets (HP:0006565)1.84136473
169Abnormality of vitamin B metabolism (HP:0004340)1.82748819
170Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80840699
171Optic disc pallor (HP:0000543)1.78335884
1723-Methylglutaconic aciduria (HP:0003535)1.77563847
173Postaxial hand polydactyly (HP:0001162)1.75737640
174Dialeptic seizures (HP:0011146)1.75461329
175Abnormal ciliary motility (HP:0012262)1.75446577
176Optic nerve hypoplasia (HP:0000609)1.75307548
177Aplasia/Hypoplasia of the uvula (HP:0010293)1.74753374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.54592758
2PDK43.82837209
3PDK33.82837209
4LMTK23.15555270
5TTN3.04759173
6OBSCN3.01483529
7TRIB32.72215390
8BMPR1B2.67942341
9PDK22.66441575
10MAP4K22.63919870
11MYLK2.59730232
12PKN22.52723234
13ADRBK22.51082163
14INSRR2.46572297
15PHKG22.42320301
16PHKG12.42320301
17GRK12.41132444
18ACVR1B2.28556734
19PINK12.25062104
20WNK42.19993448
21NUAK12.09802614
22ERN12.07748533
23SIK12.02432330
24TNIK1.91164935
25TIE11.77093858
26CASK1.75411507
27FLT31.75017350
28FGFR41.64539314
29NEK91.64347408
30MKNK21.57226379
31MAPK131.57139200
32STK391.54452485
33MAP3K41.53594330
34PIK3CA1.47333738
35NEK11.38126470
36MST41.35440494
37MUSK1.31881596
38PRKAA21.28639771
39TLK11.27492884
40CAMK1D1.20419351
41TRIM281.17014138
42PNCK1.14692318
43OXSR11.11715550
44MAP2K71.08464496
45PRKCG1.07895106
46FER1.05077724
47EPHB11.03069843
48MAPK121.02941792
49BRSK21.00361634
50STK160.99272901
51MAP3K70.99242046
52GRK70.98289256
53RIPK10.96923336
54PRKAA10.95203206
55TGFBR20.94669340
56MAP2K30.93189373
57DMPK0.92822822
58PRKCI0.91683180
59DAPK20.91577941
60STK240.91359317
61VRK10.91305966
62PRKD10.90824505
63PIK3CG0.90505789
64PLK20.89714776
65VRK20.89290889
66DYRK20.89247795
67CSNK1G10.89033573
68PLK30.88664289
69MST1R0.88025093
70JAK10.85102265
71MKNK10.84857723
72NTRK30.84379150
73KDR0.83620506
74FRK0.82974137
75EIF2AK30.82888447
76CAMK2D0.82315455
77PAK30.81649254
78PDPK10.79969916
79ADRBK10.79636835
80TAOK30.78842408
81SGK4940.78716075
82SGK2230.78716075
83MARK10.75593643
84CSNK1G20.75370771
85SGK30.75184010
86STK38L0.73511737
87WNK30.73189466
88NME10.73078056
89TGFBR10.72962449
90STK30.72237960
91MAPK110.72047958
92ERBB30.71591116
93WEE10.69928183
94PRKACG0.68953459
95CSNK1G30.68759111
96LATS10.68415340
97JAK20.67170101
98NLK0.66995896
99PDK10.66309668
100AKT30.63658815
101CSNK1A1L0.60706812
102SGK20.60036118
103PRKCH0.59969035
104TXK0.59901428
105CAMK1G0.59761645
106PKN10.59462846
107CAMK2G0.59373965
108PLK40.58069751
109MET0.57926274
110MAP3K30.57245216
111PLK10.57037489
112TAF10.56598078
113FGFR20.56456929
114WNK10.56033931
115CSNK1A10.52821280
116MAP2K60.52634891
117ROCK10.52556370
118EPHA40.52239305
119TYK20.52187346
120TSSK60.51742751
121MAP2K40.51008644
122ABL20.50871306
123ERBB40.50061834
124PRKG20.49525472
125BCR0.49124664
126MAP3K50.47532242
127CAMK40.47321515
128EPHA30.47018770
129PDGFRA0.46490226
130PTK60.46310009
131PRKCQ0.44659444
132ZAK0.44529274
133STK40.44006110
134PRKCE0.43514268
135STK110.42226936
136PTK2B0.42216799
137PRKACA0.41474845
138TRPM70.40416159
139IRAK30.40237789
140CAMKK20.39265269
141MAPKAPK50.39258428
142PRKCZ0.39020299
143TBK10.38968947
144GSK3A0.37290960
145RPS6KA50.36490437
146NEK20.36383320
147ILK0.36264125
148PRKACB0.36263237
149PRKG10.35983210
150CSNK1D0.35857103
151PRKCA0.35230255
152PASK0.34852499
153CAMK2A0.33109446
154BUB10.33070100
155MAPK70.32759399
156TTK0.32704985
157RET0.32637276
158ATM0.32493643
159MAPK150.32016198
160MAPK40.31948693
161MARK30.31556089
162CHEK20.31160109
163IGF1R0.31064907
164MAP2K10.30149438
165MAPKAPK30.29763422
166CAMK10.28535879
167ITK0.27173885
168DAPK30.25404569

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.77182600
2Propanoate metabolism_Homo sapiens_hsa006403.65971698
3Fatty acid degradation_Homo sapiens_hsa000713.54765030
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.40802958
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.13476959
6Fatty acid metabolism_Homo sapiens_hsa012122.92700649
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82319705
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78888226
9Nitrogen metabolism_Homo sapiens_hsa009102.75444798
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.59070547
11Butanoate metabolism_Homo sapiens_hsa006502.55907638
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40895667
13Tryptophan metabolism_Homo sapiens_hsa003802.31614409
14Fatty acid elongation_Homo sapiens_hsa000622.26389848
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24253296
16Pyruvate metabolism_Homo sapiens_hsa006202.24150173
17PPAR signaling pathway_Homo sapiens_hsa033202.23022496
18Arginine biosynthesis_Homo sapiens_hsa002202.15281629
19Protein export_Homo sapiens_hsa030602.11543804
20Phototransduction_Homo sapiens_hsa047442.10805325
21Carbon metabolism_Homo sapiens_hsa012002.10444107
22Peroxisome_Homo sapiens_hsa041462.05092358
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04221650
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98277421
25beta-Alanine metabolism_Homo sapiens_hsa004101.83643954
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70092160
27One carbon pool by folate_Homo sapiens_hsa006701.67926103
28Homologous recombination_Homo sapiens_hsa034401.66939677
29RNA polymerase_Homo sapiens_hsa030201.55562948
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50525344
31Fanconi anemia pathway_Homo sapiens_hsa034601.49498864
32Nicotine addiction_Homo sapiens_hsa050331.47473919
33RNA degradation_Homo sapiens_hsa030181.45957275
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44593404
35Sulfur metabolism_Homo sapiens_hsa009201.43900761
36Ether lipid metabolism_Homo sapiens_hsa005651.40463043
37Basal transcription factors_Homo sapiens_hsa030221.38035888
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33489409
39Complement and coagulation cascades_Homo sapiens_hsa046101.31684661
40Starch and sucrose metabolism_Homo sapiens_hsa005001.31089889
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30682308
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29625538
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25380347
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25270292
45Biosynthesis of amino acids_Homo sapiens_hsa012301.25225590
46Histidine metabolism_Homo sapiens_hsa003401.23930587
47Fatty acid biosynthesis_Homo sapiens_hsa000611.23714492
48Caffeine metabolism_Homo sapiens_hsa002321.23385344
49Oxidative phosphorylation_Homo sapiens_hsa001901.21315261
50Phenylalanine metabolism_Homo sapiens_hsa003601.18101555
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15202166
52Insulin secretion_Homo sapiens_hsa049111.13619258
53Parkinsons disease_Homo sapiens_hsa050121.13283526
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12161959
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07101167
56Taste transduction_Homo sapiens_hsa047421.06416295
57Chemical carcinogenesis_Homo sapiens_hsa052041.06401921
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06265528
59Bile secretion_Homo sapiens_hsa049761.04819726
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03602357
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03181284
62Olfactory transduction_Homo sapiens_hsa047401.01405753
63Tyrosine metabolism_Homo sapiens_hsa003501.00304364
64ABC transporters_Homo sapiens_hsa020100.98867858
65Cardiac muscle contraction_Homo sapiens_hsa042600.98044935
66Selenocompound metabolism_Homo sapiens_hsa004500.95308097
67Circadian rhythm_Homo sapiens_hsa047100.94478361
68Arginine and proline metabolism_Homo sapiens_hsa003300.94321614
69Glycerolipid metabolism_Homo sapiens_hsa005610.92205560
70Fat digestion and absorption_Homo sapiens_hsa049750.91118435
71Arachidonic acid metabolism_Homo sapiens_hsa005900.89499954
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.88764501
73Morphine addiction_Homo sapiens_hsa050320.88137262
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.86348054
75Purine metabolism_Homo sapiens_hsa002300.85546069
76Retinol metabolism_Homo sapiens_hsa008300.82623160
77Folate biosynthesis_Homo sapiens_hsa007900.80929376
78Lysine degradation_Homo sapiens_hsa003100.80862327
79Non-homologous end-joining_Homo sapiens_hsa034500.80786564
80GABAergic synapse_Homo sapiens_hsa047270.80521598
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80029844
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.79203628
83Alzheimers disease_Homo sapiens_hsa050100.78271842
84Serotonergic synapse_Homo sapiens_hsa047260.77614053
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77076022
86Staphylococcus aureus infection_Homo sapiens_hsa051500.75227998
87Circadian entrainment_Homo sapiens_hsa047130.73744257
88Collecting duct acid secretion_Homo sapiens_hsa049660.71780879
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.71216230
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.68599380
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66714236
92Proteasome_Homo sapiens_hsa030500.65878986
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64760179
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61413854
95Glutamatergic synapse_Homo sapiens_hsa047240.60593910
96Vitamin B6 metabolism_Homo sapiens_hsa007500.60521078
97Dilated cardiomyopathy_Homo sapiens_hsa054140.59369184
98Pentose phosphate pathway_Homo sapiens_hsa000300.58459109
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58046193
100Insulin resistance_Homo sapiens_hsa049310.57927224
101Metabolic pathways_Homo sapiens_hsa011000.57796048
102Pyrimidine metabolism_Homo sapiens_hsa002400.57567301
103Sulfur relay system_Homo sapiens_hsa041220.57269026
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57129664
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56987237
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56842142
107Glutathione metabolism_Homo sapiens_hsa004800.56482899
108Vitamin digestion and absorption_Homo sapiens_hsa049770.55187286
109Mineral absorption_Homo sapiens_hsa049780.54944389
110Salivary secretion_Homo sapiens_hsa049700.51022924
111Steroid biosynthesis_Homo sapiens_hsa001000.50710049
112Nucleotide excision repair_Homo sapiens_hsa034200.48157480
113Huntingtons disease_Homo sapiens_hsa050160.46859101
114Glucagon signaling pathway_Homo sapiens_hsa049220.46353570
115Fructose and mannose metabolism_Homo sapiens_hsa000510.44064354
116Galactose metabolism_Homo sapiens_hsa000520.42790021
117Calcium signaling pathway_Homo sapiens_hsa040200.41738287
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40666937
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40099776
120AMPK signaling pathway_Homo sapiens_hsa041520.37736926
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33150172
122Insulin signaling pathway_Homo sapiens_hsa049100.24478333
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.21699005
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20989492
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19617529
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.18400839
127Linoleic acid metabolism_Homo sapiens_hsa005910.06155923
128Lysosome_Homo sapiens_hsa041420.02946806
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.01534551
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00410280
131Prion diseases_Homo sapiens_hsa05020-0.0622753
132Protein digestion and absorption_Homo sapiens_hsa04974-0.0593614
133Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0541328
134Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0541127
135Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0446430
136Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0371940
137Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0362790
138Type II diabetes mellitus_Homo sapiens_hsa04930-0.0136207
139Regulation of autophagy_Homo sapiens_hsa04140-0.0008892

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