PTGS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine secretion (GO:0090197)6.10102167
2thrombin receptor signaling pathway (GO:0070493)6.00494911
3regulation of platelet aggregation (GO:0090330)5.41552285
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.98349044
5regulation of chemokine secretion (GO:0090196)4.93018812
6regulation of platelet activation (GO:0010543)4.91259262
7lipoxygenase pathway (GO:0019372)4.91103248
8negative regulation of homotypic cell-cell adhesion (GO:0034111)4.50029737
9positive regulation of mast cell activation (GO:0033005)4.47452065
10production of molecular mediator involved in inflammatory response (GO:0002532)4.42360336
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.41010424
12angiogenesis involved in wound healing (GO:0060055)4.38586745
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.31999358
14regulation of interferon-beta biosynthetic process (GO:0045357)4.22517888
15adenosine receptor signaling pathway (GO:0001973)4.19994818
16microglial cell activation (GO:0001774)4.12561936
17modulation by symbiont of host defense response (GO:0052031)4.08150123
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.08150123
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.08150123
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.08150123
21modulation by symbiont of host immune response (GO:0052553)4.08150123
22positive regulation by symbiont of host defense response (GO:0052509)4.08150123
23regulation of integrin-mediated signaling pathway (GO:2001044)3.95383167
24negative regulation of platelet activation (GO:0010544)3.94784937
25cellular extravasation (GO:0045123)3.94549637
26negative regulation of granulocyte differentiation (GO:0030853)3.91277632
27macrophage activation involved in immune response (GO:0002281)3.85380119
28regulation of mast cell degranulation (GO:0043304)3.82825276
29neutrophil activation (GO:0042119)3.74992139
30platelet degranulation (GO:0002576)3.65518335
31homotypic cell-cell adhesion (GO:0034109)3.60637020
32regulation of mast cell activation involved in immune response (GO:0033006)3.59742347
33response to peptidoglycan (GO:0032494)3.59040017
34pinocytosis (GO:0006907)3.56340307
35megakaryocyte development (GO:0035855)3.55567759
36positive regulation of receptor recycling (GO:0001921)3.54846526
37blood coagulation, intrinsic pathway (GO:0007597)3.53642565
38apoptotic cell clearance (GO:0043277)3.52112680
39granulocyte activation (GO:0036230)3.51461265
40regulation of homotypic cell-cell adhesion (GO:0034110)3.48726107
41extracellular fibril organization (GO:0043206)3.46789825
42response to muramyl dipeptide (GO:0032495)3.45999219
43regulation of mast cell activation (GO:0033003)3.45865422
44positive regulation of mast cell degranulation (GO:0043306)3.41304296
45positive regulation of mast cell activation involved in immune response (GO:0033008)3.41304296
46positive regulation of macrophage differentiation (GO:0045651)3.37628355
47endothelium development (GO:0003158)3.34843082
48mannose metabolic process (GO:0006013)3.32149952
49fibril organization (GO:0097435)3.30063800
50keratan sulfate catabolic process (GO:0042340)3.28737488
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28048660
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28048660
53positive regulation of antigen processing and presentation (GO:0002579)3.27622144
54purinergic nucleotide receptor signaling pathway (GO:0035590)3.27149682
55positive regulation of Rho protein signal transduction (GO:0035025)3.25582813
56desmosome organization (GO:0002934)3.25233267
57platelet activation (GO:0030168)3.22469998
58leukotriene metabolic process (GO:0006691)3.22387840
59positive regulation of interferon-alpha production (GO:0032727)3.21146858
60negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.18429362
61regulation of leukocyte degranulation (GO:0043300)3.16203284
62negative regulation of interleukin-17 production (GO:0032700)3.15593649
63positive regulation of blood coagulation (GO:0030194)3.15218345
64positive regulation of hemostasis (GO:1900048)3.15218345
65cellular response to thyroid hormone stimulus (GO:0097067)3.13858504
66regulation of myeloid leukocyte mediated immunity (GO:0002886)3.12610473
67* cyclooxygenase pathway (GO:0019371)3.11704622
68positive regulation of endothelial cell differentiation (GO:0045603)3.09835171
69response to laminar fluid shear stress (GO:0034616)3.07610063
70neutrophil activation involved in immune response (GO:0002283)3.07607526
71macrophage differentiation (GO:0030225)3.07046127
72regulation of apoptotic cell clearance (GO:2000425)3.04799426
73protein neddylation (GO:0045116)3.03881289
74hyaluronan catabolic process (GO:0030214)3.03661388
75macrophage activation (GO:0042116)3.02951594
76response to fungus (GO:0009620)3.00210367
77antigen processing and presentation of endogenous antigen (GO:0019883)2.99957694
78negative regulation of erythrocyte differentiation (GO:0045647)2.99445275
79positive regulation of B cell differentiation (GO:0045579)2.99160799
80regulation of interferon-alpha production (GO:0032647)2.98718823
81membrane invagination (GO:0010324)2.98352209
82definitive hemopoiesis (GO:0060216)2.97779649
83regulation of B cell receptor signaling pathway (GO:0050855)2.96639404
84antigen processing and presentation via MHC class Ib (GO:0002475)2.95422440
85negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.94635763
86negative regulation of T-helper cell differentiation (GO:0045623)2.94635763
87positive regulation of coagulation (GO:0050820)2.90410403
88regulation of antigen processing and presentation (GO:0002577)2.90320390
89platelet formation (GO:0030220)2.89609675
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88917839
91positive regulation of systemic arterial blood pressure (GO:0003084)2.88218478
92negative regulation of interleukin-8 production (GO:0032717)2.87080486
93negative regulation of stress fiber assembly (GO:0051497)2.87042293
94G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.86070675
95Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84825760
96regulation of T-helper 2 cell differentiation (GO:0045628)2.84222932
97leukocyte migration involved in inflammatory response (GO:0002523)2.84183565
98peptide catabolic process (GO:0043171)2.83750079
99germ cell migration (GO:0008354)2.81165470
100response to host (GO:0075136)2.79873052
101response to host defenses (GO:0052200)2.79873052
102response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.79873052
103hypotonic response (GO:0006971)2.79101321
104response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78212277
105response to host immune response (GO:0052572)2.78212277
106negative regulation of interleukin-6 production (GO:0032715)2.76965234
107positive regulation of leukocyte degranulation (GO:0043302)2.76830137
108positive regulation of cellular amide metabolic process (GO:0034250)2.75441389
109surfactant homeostasis (GO:0043129)2.73704629
110regulation of integrin activation (GO:0033623)2.73644366
111myeloid cell activation involved in immune response (GO:0002275)2.73601617
112negative regulation of norepinephrine secretion (GO:0010700)2.73489466
113ceramide catabolic process (GO:0046514)2.72157772
114negative regulation of protein localization to plasma membrane (GO:1903077)2.72020931
115respiratory burst (GO:0045730)2.71909164
116regulation of monocyte chemotaxis (GO:0090025)2.69376299
117positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.69345113
118detection of molecule of bacterial origin (GO:0032490)2.69338495
119leukocyte degranulation (GO:0043299)2.68832083
120response to interferon-alpha (GO:0035455)2.67009529
121negative regulation of neural precursor cell proliferation (GO:2000178)2.66182848
122regulation of T-helper 1 cell differentiation (GO:0045625)2.65944250
123sodium-independent organic anion transport (GO:0043252)2.65941849
124phagocytosis, engulfment (GO:0006911)2.65551356
125skin morphogenesis (GO:0043589)2.65512486
126negative regulation of thymocyte apoptotic process (GO:0070244)2.64271470
127detection of other organism (GO:0098543)2.61096036
128regulation of blood coagulation (GO:0030193)2.61037354
129regulation of hemostasis (GO:1900046)2.61037354
130glycosphingolipid catabolic process (GO:0046479)2.60231757
131leukotriene biosynthetic process (GO:0019370)2.60094824
132negative regulation of focal adhesion assembly (GO:0051895)2.60077220
133negative regulation of cell junction assembly (GO:1901889)2.60077220
134negative regulation of adherens junction organization (GO:1903392)2.60077220
135positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.58820970
136regulation of phagocytosis (GO:0050764)2.58261245
137regulation of macrophage chemotaxis (GO:0010758)2.57599842
138regulation of MHC class II biosynthetic process (GO:0045346)2.57574333
139stress fiber assembly (GO:0043149)2.56766647
140purinergic receptor signaling pathway (GO:0035587)2.56248219
141positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.55838671
142negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.55241300
143negative regulation of cell killing (GO:0031342)2.55241300
144regulation of interleukin-17 production (GO:0032660)2.52831241
145hemidesmosome assembly (GO:0031581)2.52418957
146gland morphogenesis (GO:0022612)2.52151044
147germinal center formation (GO:0002467)2.52143189
148lipopolysaccharide-mediated signaling pathway (GO:0031663)2.52129197
149triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.51697951
150detection of external biotic stimulus (GO:0098581)2.51275721
151negative regulation of interleukin-12 production (GO:0032695)2.50963939
152regulation of interleukin-8 secretion (GO:2000482)2.50807515
153autophagic vacuole fusion (GO:0000046)2.50621117
154* arachidonic acid metabolic process (GO:0019369)2.49308820
155macrophage chemotaxis (GO:0048246)2.49078624
156negative regulation of phagocytosis (GO:0050765)2.48262646
157positive regulation of gamma-delta T cell activation (GO:0046645)2.46298318
158negative regulation of bone mineralization (GO:0030502)2.44603273
159positive regulation of monocyte chemotaxis (GO:0090026)2.43344090
160positive regulation of phagocytosis (GO:0050766)2.43129729
161immunoglobulin mediated immune response (GO:0016064)2.42969380
162regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.42915343
163response to fluid shear stress (GO:0034405)2.37903017
164positive regulation of NF-kappaB import into nucleus (GO:0042346)2.36276583
165positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.35938016
166platelet aggregation (GO:0070527)2.34621903
167hepatocyte apoptotic process (GO:0097284)2.34386639
168pathway-restricted SMAD protein phosphorylation (GO:0060389)2.32458448
169* icosanoid biosynthetic process (GO:0046456)2.32364661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.02353488
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.55845078
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.78112593
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.42599409
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.29398579
6SCL_19346495_ChIP-Seq_HPC-7_Human3.13324637
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12900350
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.12532813
9GATA1_19941826_ChIP-Seq_K562_Human2.97291123
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.93451553
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92252729
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.90680574
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79064474
14* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70512021
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64689466
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51494805
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.47862080
18* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.46523559
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44149943
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.40092571
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08098762
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06441761
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04147670
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93008251
25GATA1_22025678_ChIP-Seq_K562_Human1.91662428
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.91274154
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88348983
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.86782859
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85099284
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83054606
31* SPI1_23547873_ChIP-Seq_NB4_Human1.80901127
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.76863764
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.76790394
34VDR_24763502_ChIP-Seq_THP-1_Human1.76660775
35* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73821131
36VDR_21846776_ChIP-Seq_THP-1_Human1.66655990
37SPI1_23127762_ChIP-Seq_K562_Human1.63936012
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.63005865
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.62820532
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61989896
41* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59896775
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.55808063
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53595840
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53595840
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.51707891
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51256641
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50550705
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48334572
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47908179
50RUNX_20019798_ChIP-Seq_JUKART_Human1.47400184
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44149606
52* SOX2_20726797_ChIP-Seq_SW620_Human1.43104807
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41821060
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41685887
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.40234050
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40078626
57MAF_26560356_Chip-Seq_TH1_Human1.39049466
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39029296
59CJUN_26792858_Chip-Seq_BT549_Human1.38059965
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36010600
61PU_27001747_Chip-Seq_BMDM_Mouse1.34904747
62CLOCK_20551151_ChIP-Seq_293T_Human1.34811507
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33779753
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33233725
65MYB_26560356_Chip-Seq_TH2_Human1.33022484
66GATA1_19941827_ChIP-Seq_MEL86_Mouse1.30456567
67ELK4_26923725_Chip-Seq_MESODERM_Mouse1.28966897
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26721278
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25694427
70* NCOR1_26117541_ChIP-Seq_K562_Human1.24616238
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23377793
72VDR_24787735_ChIP-Seq_THP-1_Human1.23335670
73* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22952142
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22566712
75LXR_22292898_ChIP-Seq_THP-1_Human1.20926933
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19992293
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19766623
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18668074
79* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18386199
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17613930
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17613930
82* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17523718
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17398499
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17113987
85* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17107319
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16757990
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16292773
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12779017
89CDX2_20551321_ChIP-Seq_CACO-2_Human1.12095966
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10564212
91UTX_26944678_Chip-Seq_JUKART_Human1.10082315
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10030420
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09980215
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08570882
95* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08487374
96GATA2_19941826_ChIP-Seq_K562_Human1.08152086
97ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07950635
98* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07122033
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06739664
100MYB_26560356_Chip-Seq_TH1_Human1.06106778
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05457279
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.05371530
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05117170
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02248205
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02169152
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.00025654
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00007625
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98781364
109* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98359762
110* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96373154
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95901767
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95807376
113* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95095357
114PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95071979
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93152118
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93081489
117GATA3_27048872_Chip-Seq_THYMUS_Human0.92229188
118MYC_22102868_ChIP-Seq_BL_Human0.91725955
119WT1_19549856_ChIP-ChIP_CCG9911_Human0.90219561
120SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88189196
121KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87628491
122KDM2B_26808549_Chip-Seq_DND41_Human0.87351442
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86654142
124BRD4_25478319_ChIP-Seq_HGPS_Human0.84069145
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83298782
126* SPI1_20517297_ChIP-Seq_HL60_Human0.82425857
127* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79930969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol3.04800624
2MP0005058_abnormal_lysosome_morphology2.97638087
3MP0002148_abnormal_hypersensitivity_rea2.67899486
4MP0003724_increased_susceptibility_to2.62704567
5MP0003303_peritoneal_inflammation2.56223588
6MP0004510_myositis2.56096687
7MP0003566_abnormal_cell_adhesion2.44954156
8* MP0003436_decreased_susceptibility_to2.43301586
9* MP0005464_abnormal_platelet_physiology2.43159499
10MP0005275_abnormal_skin_tensile2.38755832
11MP0006082_CNS_inflammation2.32409357
12MP0008438_abnormal_cutaneous_collagen2.30760572
13MP0002419_abnormal_innate_immunity2.30688810
14MP0001835_abnormal_antigen_presentation2.29611927
15MP0000465_gastrointestinal_hemorrhage2.16297427
16MP0002796_impaired_skin_barrier2.08509059
17MP0004947_skin_inflammation1.98412360
18MP0003300_gastrointestinal_ulcer1.96249234
19* MP0001533_abnormal_skeleton_physiology1.95529765
20MP0005025_abnormal_response_to1.93066476
21MP0009785_altered_susceptibility_to1.83039721
22MP0006054_spinal_hemorrhage1.80962664
23MP0000343_altered_response_to1.78826505
24MP0003075_altered_response_to1.78758337
25* MP0005000_abnormal_immune_tolerance1.75348994
26MP0002452_abnormal_antigen_presenting1.74093450
27MP0005671_abnormal_response_to1.74067099
28MP0002060_abnormal_skin_morphology1.73830894
29MP0003705_abnormal_hypodermis_morpholog1.72456036
30MP0000685_abnormal_immune_system1.67986831
31* MP0005023_abnormal_wound_healing1.67410495
32MP0001851_eye_inflammation1.64422190
33MP0003279_aneurysm1.63929059
34MP0003172_abnormal_lysosome_physiology1.62997091
35MP0001958_emphysema1.62099813
36MP0002396_abnormal_hematopoietic_system1.57888587
37MP0009840_abnormal_foam_cell1.52262210
38MP0004782_abnormal_surfactant_physiolog1.51924303
39MP0002723_abnormal_immune_serum1.51408244
40MP0001800_abnormal_humoral_immune1.50783868
41MP0005387_immune_system_phenotype1.49405453
42MP0001790_abnormal_immune_system1.49405453
43MP0001819_abnormal_immune_cell1.47211083
44MP0010368_abnormal_lymphatic_system1.46584537
45MP0003453_abnormal_keratinocyte_physiol1.46152835
46MP0010352_gastrointestinal_tract_polyps1.46001412
47MP0002420_abnormal_adaptive_immunity1.45857016
48MP0004808_abnormal_hematopoietic_stem1.45728355
49MP0005397_hematopoietic_system_phenotyp1.41925645
50MP0001545_abnormal_hematopoietic_system1.41925645
51MP0003183_abnormal_peptide_metabolism1.38517865
52MP0004084_abnormal_cardiac_muscle1.38185078
53* MP0001845_abnormal_inflammatory_respons1.37990874
54MP0002405_respiratory_system_inflammati1.37734354
55MP0005083_abnormal_biliary_tract1.37667149
56MP0009278_abnormal_bone_marrow1.36837471
57MP0001853_heart_inflammation1.32308956
58* MP0001216_abnormal_epidermal_layer1.31914368
59MP0002933_joint_inflammation1.30493987
60MP0000767_abnormal_smooth_muscle1.28208218
61MP0002166_altered_tumor_susceptibility1.27055824
62MP0003656_abnormal_erythrocyte_physiolo1.26952291
63MP0005501_abnormal_skin_physiology1.26701862
64MP0004272_abnormal_basement_membrane1.26584946
65MP0003941_abnormal_skin_development1.22825711
66* MP0010155_abnormal_intestine_physiology1.22229507
67MP0008469_abnormal_protein_level1.21534815
68* MP0005390_skeleton_phenotype1.21402372
69MP0002254_reproductive_system_inflammat1.17916328
70MP0003828_pulmonary_edema1.17545591
71MP0005166_decreased_susceptibility_to1.16907414
72MP0002998_abnormal_bone_remodeling1.15810305
73MP0001542_abnormal_bone_strength1.15791338
74MP0008260_abnormal_autophagy1.15350708
75MP0000249_abnormal_blood_vessel1.13242571
76MP0001663_abnormal_digestive_system1.13208044
77MP0002132_abnormal_respiratory_system1.10507259
78* MP0000230_abnormal_systemic_arterial1.09273450
79MP0010234_abnormal_vibrissa_follicle1.08095718
80MP0003091_abnormal_cell_migration1.03935217
81MP0003045_fibrosis1.03274904
82MP0005503_abnormal_tendon_morphology1.01410396
83MP0009333_abnormal_splenocyte_physiolog1.01299224
84MP0004036_abnormal_muscle_relaxation1.01253842
85MP0005164_abnormal_response_to1.00944324
86MP0000716_abnormal_immune_system0.99834040
87MP0002006_tumorigenesis0.99054672
88MP0005595_abnormal_vascular_smooth0.98310253
89MP0001873_stomach_inflammation0.97673920
90MP0000015_abnormal_ear_pigmentation0.97614372
91MP0009384_cardiac_valve_regurgitation0.97114524
92MP0009764_decreased_sensitivity_to0.96991068
93MP0002877_abnormal_melanocyte_morpholog0.94933437
94MP0002398_abnormal_bone_marrow0.93202913
95MP0001243_abnormal_dermal_layer0.92986503
96MP0002295_abnormal_pulmonary_circulatio0.91566418
97MP0001191_abnormal_skin_condition0.90684412
98MP0005165_increased_susceptibility_to0.90384819
99MP0009931_abnormal_skin_appearance0.90282103
100MP0003448_altered_tumor_morphology0.90183999
101MP0000858_altered_metastatic_potential0.89512994
102MP0008775_abnormal_heart_ventricle0.89339844
103MP0001879_abnormal_lymphatic_vessel0.89177727
104MP0005167_abnormal_blood-brain_barrier0.88613574
105* MP0002722_abnormal_immune_system0.88467753
106* MP0000689_abnormal_spleen_morphology0.88317133
107MP0003795_abnormal_bone_structure0.87729379
108MP0001915_intracranial_hemorrhage0.87060215
109MP0002429_abnormal_blood_cell0.86357160
110MP0004883_abnormal_blood_vessel0.86204772
111* MP0010771_integument_phenotype0.84664029
112MP0003866_abnormal_defecation0.84083866
113MP0004185_abnormal_adipocyte_glucose0.83078458
114MP0003763_abnormal_thymus_physiology0.81759851
115MP0001849_ear_inflammation0.79994823
116MP0004130_abnormal_muscle_cell0.79174992
117MP0005409_darkened_coat_color0.77863327
118MP0005076_abnormal_cell_differentiation0.77113029
119MP0005381_digestive/alimentary_phenotyp0.74722493
120* MP0009763_increased_sensitivity_to0.73120953
121MP0005084_abnormal_gallbladder_morpholo0.72943452
122* MP0000490_abnormal_crypts_of0.72691157
123MP0010386_abnormal_urinary_bladder0.72685819
124* MP0002128_abnormal_blood_circulation0.72277592

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)8.26384799
2Systemic lupus erythematosus (HP:0002725)6.88347829
3Glomerulonephritis (HP:0000099)4.90073581
4Recurrent abscess formation (HP:0002722)4.30290933
5Eczematoid dermatitis (HP:0000976)4.14691285
6Interstitial pulmonary disease (HP:0006530)4.05631787
7Complement deficiency (HP:0004431)3.90828245
8Recurrent bacterial skin infections (HP:0005406)3.85328177
9Abnormality of complement system (HP:0005339)3.82747002
10Recurrent gram-negative bacterial infections (HP:0005420)3.62756628
11Dysostosis multiplex (HP:0000943)3.61942836
12Cerebral aneurysm (HP:0004944)3.56521670
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.52187839
14Abnormality of glycolipid metabolism (HP:0010969)3.52187839
15Abnormality of liposaccharide metabolism (HP:0010968)3.52187839
16Arterial tortuosity (HP:0005116)3.45908495
17Increased cerebral lipofuscin (HP:0011813)3.44786861
18Aortic aneurysm (HP:0004942)3.43349128
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.37362365
20Vacuolated lymphocytes (HP:0001922)3.36631073
21Conjunctival telangiectasia (HP:0000524)3.31494836
22Hyperlipoproteinemia (HP:0010980)3.29339527
23Abnormality of the vasculature of the conjunctiva (HP:0008054)3.26821953
24Vascular tortuosity (HP:0004948)3.20487297
25Nephritis (HP:0000123)3.19058987
26Aortic dissection (HP:0002647)3.08099433
27Cervical subluxation (HP:0003308)3.03914917
28Hematochezia (HP:0002573)3.00190818
29Osteolytic defects of the hand bones (HP:0009699)2.92852298
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.92852298
31Mucopolysacchariduria (HP:0008155)2.90672890
32Urinary glycosaminoglycan excretion (HP:0003541)2.90672890
33Protrusio acetabuli (HP:0003179)2.82309057
34Abnormality of polysaccharide metabolism (HP:0011012)2.67003657
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.67003657
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.67003657
37Spondylolisthesis (HP:0003302)2.65360666
38Vertebral compression fractures (HP:0002953)2.63215120
39Abnormality of the common coagulation pathway (HP:0010990)2.60601636
40Hepatosplenomegaly (HP:0001433)2.58640986
41Polycythemia (HP:0001901)2.58184140
42Poikilocytosis (HP:0004447)2.57219607
43Chronic obstructive pulmonary disease (HP:0006510)2.56902271
44Petechiae (HP:0000967)2.55106842
45Stomatitis (HP:0010280)2.50387404
46Myositis (HP:0100614)2.50060213
47Prolonged bleeding time (HP:0003010)2.46420674
48Pustule (HP:0200039)2.45994414
49Thrombocytosis (HP:0001894)2.45169071
50Abnormality of macrophages (HP:0004311)2.44059248
51Abnormality of the heme biosynthetic pathway (HP:0010472)2.41756341
52Joint stiffness (HP:0001387)2.41673122
53Premature rupture of membranes (HP:0001788)2.41497055
54Peritonitis (HP:0002586)2.41397626
55Abnormality of the lumbar spine (HP:0100712)2.36255808
56Acanthocytosis (HP:0001927)2.35749605
57Abnormality of skeletal muscle fiber size (HP:0012084)2.33142632
58Cellulitis (HP:0100658)2.32286918
59Slender build (HP:0001533)2.31014536
60Increased variability in muscle fiber diameter (HP:0003557)2.30964218
61Thoracic kyphosis (HP:0002942)2.29480670
62Abnormal platelet function (HP:0011869)2.28255813
63Impaired platelet aggregation (HP:0003540)2.28255813
64Epistaxis (HP:0000421)2.27205885
65Follicular hyperkeratosis (HP:0007502)2.27000045
66Periodontitis (HP:0000704)2.24262274
67Thick nail (HP:0001805)2.23860240
68Erythema (HP:0010783)2.22876841
69Recurrent skin infections (HP:0001581)2.21857865
70Elevated erythrocyte sedimentation rate (HP:0003565)2.20289944
71Abnormality of iron homeostasis (HP:0011031)2.18198880
72Axonal loss (HP:0003447)2.14904652
73Polygenic inheritance (HP:0010982)2.14412267
74Purpura (HP:0000979)2.12733989
75Increased IgE level (HP:0003212)2.12629120
76Spontaneous hematomas (HP:0007420)2.10279628
77Colitis (HP:0002583)2.10080342
78Facial diplegia (HP:0001349)2.09874434
79Disinhibition (HP:0000734)2.08522224
80Loss of speech (HP:0002371)2.08459324
81Menorrhagia (HP:0000132)2.08028630
82Orchitis (HP:0100796)2.04844295
83Mitral valve prolapse (HP:0001634)2.04235302
84Atrophic scars (HP:0001075)2.02466308
85Dyschromatopsia (HP:0007641)2.02431973
86Abnormal pupillary function (HP:0007686)1.99694713
87Increased serum ferritin (HP:0003281)1.99317178
88Beaking of vertebral bodies (HP:0004568)1.98291883
89Distal lower limb muscle weakness (HP:0009053)1.95401166
90Distal lower limb amyotrophy (HP:0008944)1.93040531
91Gingivitis (HP:0000230)1.92749200
92Episodic fever (HP:0001954)1.91846723
93Urethral obstruction (HP:0000796)1.91741088
94Chest pain (HP:0100749)1.90970661
95Type 1 muscle fiber predominance (HP:0003803)1.90681823
96Progressive neurologic deterioration (HP:0002344)1.89640494
97Spinal rigidity (HP:0003306)1.88972431
98Shallow orbits (HP:0000586)1.88746331
99Ankle contracture (HP:0006466)1.87757577
100Myocardial infarction (HP:0001658)1.87389743
101Joint hemorrhage (HP:0005261)1.86784555
102Paralysis (HP:0003470)1.86228539
103Recurrent fungal infections (HP:0002841)1.86130980
104Retinal atrophy (HP:0001105)1.84399852
105Increased density of long bones (HP:0006392)1.81397126
106Abnormality of transition element cation homeostasis (HP:0011030)1.80676900
107Arterial thrombosis (HP:0004420)1.80023527
108Ovoid vertebral bodies (HP:0003300)1.79999602
109Abnormal platelet volume (HP:0011876)1.79491377
110Leukocytosis (HP:0001974)1.78754539
111Soft skin (HP:0000977)1.78725533
112Increased IgM level (HP:0003496)1.78566572
113Right ventricular cardiomyopathy (HP:0011663)1.78322371
114Abnormality of the thoracic spine (HP:0100711)1.77204247
115Basal ganglia calcification (HP:0002135)1.75737812
116Mucosal telangiectasiae (HP:0100579)1.75522073
117Plantar hyperkeratosis (HP:0007556)1.74159821
118Palmoplantar hyperkeratosis (HP:0000972)1.74055585
119Chronic otitis media (HP:0000389)1.73447419
120Spinal cord lesions (HP:0100561)1.73403784
121Syringomyelia (HP:0003396)1.73403784
122Pathologic fracture (HP:0002756)1.73096524
123Dilatation of the ascending aorta (HP:0005111)1.72294718
124Inflammation of the large intestine (HP:0002037)1.72151309
125Gingival bleeding (HP:0000225)1.72053017
126Epiphyseal dysplasia (HP:0002656)1.70169803
127Mediastinal lymphadenopathy (HP:0100721)1.70157414
128Abnormality of the nasal mucosa (HP:0000433)1.70062081
129Asymmetric septal hypertrophy (HP:0001670)1.68672472
130Bruising susceptibility (HP:0000978)1.68529696
131Osteomyelitis (HP:0002754)1.68075581
132Short nail (HP:0001799)1.67379336
133Obstructive lung disease (HP:0006536)1.67353848
134Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.62460893
135Abnormality of the Achilles tendon (HP:0005109)1.62260884
136Joint swelling (HP:0001386)1.60561459
137Abnormality of lateral ventricle (HP:0030047)1.59502785
138Encephalitis (HP:0002383)1.59157409
139Vertigo (HP:0002321)1.58153614
140Blue sclerae (HP:0000592)1.56841169
141Amaurosis fugax (HP:0100576)1.55688760
142Cerebral ischemia (HP:0002637)1.54847232
143Mitral stenosis (HP:0001718)1.54759125
144Urticaria (HP:0001025)1.54754319
145Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.53114831
146Xanthomatosis (HP:0000991)1.53015373
147Hypergammaglobulinemia (HP:0010702)1.52169504
148Autoimmune hemolytic anemia (HP:0001890)1.51757134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.56768552
2ERN13.00365533
3BLK2.77080986
4MAP2K32.75847457
5EEF2K2.51056398
6TRPM72.34122350
7MST1R2.33962205
8CSF1R2.16941483
9STK102.12561387
10PTK2B2.12005728
11MAPKAPK32.07587564
12TRIB32.02553353
13TYK21.90424925
14MAP3K31.90311910
15ZAP701.78322141
16MAPKAPK51.77854033
17GRK61.75380094
18TBK11.73573706
19IRAK41.73057393
20PAK41.72262361
21EIF2AK11.70020984
22GRK71.69242329
23MAPK151.65548232
24TTN1.62094055
25IRAK31.57522147
26PIK3CG1.55794349
27PKN21.54224862
28LRRK21.51815289
29PIM21.48082303
30BMPR21.47158837
31TIE11.47134977
32CAMK1D1.46738877
33GRK51.44437763
34RPS6KA41.39539716
35KIT1.37897530
36BTK1.37892959
37MATK1.37816380
38MAP4K11.36238271
39RPS6KB21.32452277
40TAOK21.28245435
41RIPK41.27191279
42TGFBR11.26398239
43HCK1.26146683
44EPHB11.23871295
45PTK61.23085169
46ERBB31.21801438
47TEC1.19761065
48MAP3K61.17996380
49IKBKB1.14936243
50JAK31.05810773
51MOS1.03345055
52CAMKK21.03167661
53NEK91.02783042
54CSK0.96817391
55MAP3K140.96359110
56NME20.95262602
57MAP3K10.94553752
58MAPKAPK20.92922077
59CLK10.92295983
60CDC42BPA0.90769314
61PDPK10.88206874
62PRPF4B0.87199545
63PAK10.86982895
64TNK20.85024434
65ADRBK10.85005141
66MAP3K50.84948640
67IKBKE0.84934417
68PDGFRA0.81804096
69KDR0.81754452
70TAOK10.80900977
71JAK10.80601234
72DMPK0.80488513
73PDGFRB0.80322371
74PDK10.79946362
75PRKD20.79625330
76MET0.79442142
77ADRBK20.79030749
78SYK0.77380649
79PAK20.77202634
80TESK20.75938866
81LYN0.75453258
82CDK30.74524553
83CDK60.73691901
84FES0.73322095
85ITK0.72506488
86ARAF0.72305182
87RIPK10.72154265
88DAPK30.71987439
89STK240.71166189
90IRAK10.70983891
91MAP3K130.70660806
92LCK0.69468631
93RET0.69371838
94MAPK120.68074228
95TESK10.67925447
96PRKD10.66994092
97DDR20.64179025
98MST40.62976894
99MAP2K60.62716040
100MAPK40.61411485
101MARK30.60473480
102TAOK30.60111244
103IGF1R0.60019460
104MYLK0.57650967
105TXK0.57364115
106BMX0.56909480
107JAK20.55821345
108EPHB20.55124469
109CAMK1G0.54785839
110ILK0.53009042
111FER0.52163550
112MAPK70.51860449
113LMTK20.51507210
114FYN0.50592240
115RPS6KA60.50267184
116EPHA20.50123087
117ABL20.49677099
118TSSK60.49204666
119DYRK1B0.48873791
120RPS6KA20.48374363
121RPS6KC10.47154150
122RPS6KL10.47154150
123PRKG20.47025456
124EGFR0.46051140
125EPHA30.45780407
126MAP2K10.44678835
127MAP3K110.44501159
128PTK20.44231273
129CHUK0.43689680
130EIF2AK20.42937513
131HIPK20.41704767
132PRKCD0.40955091
133PIM10.39793773
134FGFR30.39209768
135IRAK20.38010172
136STK30.37760729
137FGR0.37554435
138CAMKK10.37260268
139STK40.36446085
140FLT30.35902507
141SIK10.35718400

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.51571487
2Other glycan degradation_Homo sapiens_hsa005113.94220339
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.22953473
4Leishmaniasis_Homo sapiens_hsa051402.81589518
5Pertussis_Homo sapiens_hsa051332.55230544
6Lysosome_Homo sapiens_hsa041422.27160579
7Osteoclast differentiation_Homo sapiens_hsa043802.17457612
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.14046009
9Malaria_Homo sapiens_hsa051442.06477397
10Complement and coagulation cascades_Homo sapiens_hsa046101.98558950
11SNARE interactions in vesicular transport_Homo sapiens_hsa041301.76514757
12Legionellosis_Homo sapiens_hsa051341.75306024
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73574388
14Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.68319405
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.63820712
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62575190
17Tuberculosis_Homo sapiens_hsa051521.59137040
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57975634
19Toxoplasmosis_Homo sapiens_hsa051451.57819696
20* Platelet activation_Homo sapiens_hsa046111.56409664
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.53726371
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49227775
23Hematopoietic cell lineage_Homo sapiens_hsa046401.48594142
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46239115
25* Arachidonic acid metabolism_Homo sapiens_hsa005901.44382209
26B cell receptor signaling pathway_Homo sapiens_hsa046621.42995231
27Caffeine metabolism_Homo sapiens_hsa002321.40055558
28Salmonella infection_Homo sapiens_hsa051321.31320020
29ECM-receptor interaction_Homo sapiens_hsa045121.30238976
30Phagosome_Homo sapiens_hsa041451.29299009
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26418103
32Shigellosis_Homo sapiens_hsa051311.24825315
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23908851
34Amoebiasis_Homo sapiens_hsa051461.23857715
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22401240
36Antigen processing and presentation_Homo sapiens_hsa046121.20730695
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18215287
38TNF signaling pathway_Homo sapiens_hsa046681.17056300
39Gap junction_Homo sapiens_hsa045401.16340954
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14483472
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.12397402
42Influenza A_Homo sapiens_hsa051641.12062241
43Sphingolipid metabolism_Homo sapiens_hsa006001.11987317
44Allograft rejection_Homo sapiens_hsa053301.11788945
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.11734566
46Asthma_Homo sapiens_hsa053101.10854034
47Graft-versus-host disease_Homo sapiens_hsa053321.08173562
48Chronic myeloid leukemia_Homo sapiens_hsa052201.07216570
49Measles_Homo sapiens_hsa051621.04764859
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.02590152
51Prion diseases_Homo sapiens_hsa050201.02576066
52Rheumatoid arthritis_Homo sapiens_hsa053231.01734377
53Focal adhesion_Homo sapiens_hsa045101.00266610
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99624053
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.99330543
56Apoptosis_Homo sapiens_hsa042100.96420313
57Pancreatic cancer_Homo sapiens_hsa052120.95453412
58Proteoglycans in cancer_Homo sapiens_hsa052050.92655201
59Autoimmune thyroid disease_Homo sapiens_hsa053200.91717215
60ABC transporters_Homo sapiens_hsa020100.89697808
61T cell receptor signaling pathway_Homo sapiens_hsa046600.89277513
62Chemokine signaling pathway_Homo sapiens_hsa040620.87609417
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87241981
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87187795
65VEGF signaling pathway_Homo sapiens_hsa043700.87159943
66Hepatitis B_Homo sapiens_hsa051610.83910624
67Acute myeloid leukemia_Homo sapiens_hsa052210.81765737
68Adherens junction_Homo sapiens_hsa045200.81440339
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80794856
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75355516
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73295132
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71872564
73Herpes simplex infection_Homo sapiens_hsa051680.69957046
74Hepatitis C_Homo sapiens_hsa051600.68948545
75Choline metabolism in cancer_Homo sapiens_hsa052310.66898191
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66828733
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66789782
78Small cell lung cancer_Homo sapiens_hsa052220.66303538
79Collecting duct acid secretion_Homo sapiens_hsa049660.66053240
80Rap1 signaling pathway_Homo sapiens_hsa040150.65848466
81Long-term depression_Homo sapiens_hsa047300.64131338
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61327058
83Primary immunodeficiency_Homo sapiens_hsa053400.60212692
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60121794
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59974455
86Renal cell carcinoma_Homo sapiens_hsa052110.59969361
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59698404
88Endocytosis_Homo sapiens_hsa041440.58058547
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.57490838
90Pancreatic secretion_Homo sapiens_hsa049720.57046254
91Systemic lupus erythematosus_Homo sapiens_hsa053220.56866020
92Dilated cardiomyopathy_Homo sapiens_hsa054140.56222827
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.55404203
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54456432
95Ras signaling pathway_Homo sapiens_hsa040140.53200016
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52688859
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.52393571
98Ether lipid metabolism_Homo sapiens_hsa005650.52325511
99N-Glycan biosynthesis_Homo sapiens_hsa005100.51261352
100Renin-angiotensin system_Homo sapiens_hsa046140.51162418
101Endometrial cancer_Homo sapiens_hsa052130.51055354
102Type I diabetes mellitus_Homo sapiens_hsa049400.50203675
103Glioma_Homo sapiens_hsa052140.49986794
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49762689
105Linoleic acid metabolism_Homo sapiens_hsa005910.49230020
106Ribosome_Homo sapiens_hsa030100.46136004
107African trypanosomiasis_Homo sapiens_hsa051430.45998949
108Viral myocarditis_Homo sapiens_hsa054160.45907238
109Viral carcinogenesis_Homo sapiens_hsa052030.45826144
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45662709
111TGF-beta signaling pathway_Homo sapiens_hsa043500.45180790
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44575177
113Bladder cancer_Homo sapiens_hsa052190.44468806
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.43959279
115Histidine metabolism_Homo sapiens_hsa003400.43465740
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42110892
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39607107
118Chemical carcinogenesis_Homo sapiens_hsa052040.39246954
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38507453
120Notch signaling pathway_Homo sapiens_hsa043300.38222779
121Colorectal cancer_Homo sapiens_hsa052100.36304099
122HTLV-I infection_Homo sapiens_hsa051660.35593669
123* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34942443
124Pathways in cancer_Homo sapiens_hsa052000.34032009
125Prolactin signaling pathway_Homo sapiens_hsa049170.32505460
126HIF-1 signaling pathway_Homo sapiens_hsa040660.32226710
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.31324790
128MicroRNAs in cancer_Homo sapiens_hsa052060.31274810
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30663946
130Non-small cell lung cancer_Homo sapiens_hsa052230.29055032

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