PTH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular anion homeostasis (GO:0030002)9.29763298
2sulfate transmembrane transport (GO:1902358)8.48490664
3negative regulation of microtubule polymerization (GO:0031115)7.38556863
4chemosensory behavior (GO:0007635)6.99204984
5sulfate transport (GO:0008272)6.97646657
6detection of calcium ion (GO:0005513)6.95184603
7negative regulation of smooth muscle cell differentiation (GO:0051151)6.88977103
8hydrogen peroxide catabolic process (GO:0042744)6.79073532
9peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.73871834
10phosphorelay signal transduction system (GO:0000160)6.73784483
11positive regulation of sodium ion transmembrane transporter activity (GO:2000651)6.28320336
12regulation of glucose import in response to insulin stimulus (GO:2001273)6.23712786
13positive regulation of potassium ion transmembrane transporter activity (GO:1901018)6.11646952
14phenol-containing compound metabolic process (GO:0018958)6.08829627
15regulation of macrophage chemotaxis (GO:0010758)5.97416209
16bicarbonate transport (GO:0015701)5.91418511
17response to ischemia (GO:0002931)5.80469083
18short-term memory (GO:0007614)5.72771787
19cellular response to nutrient (GO:0031670)5.68394929
20hormone biosynthetic process (GO:0042446)5.65880203
21cytoskeletal anchoring at plasma membrane (GO:0007016)5.53707195
22neural tube formation (GO:0001841)5.47019026
23myelin maintenance (GO:0043217)5.32035749
24potassium ion homeostasis (GO:0055075)5.27923063
25* response to vitamin D (GO:0033280)5.25825705
26CD4-positive, alpha-beta T cell differentiation (GO:0043367)5.20092699
27positive regulation of calcium ion import (GO:0090280)5.19889036
28regulation of mononuclear cell migration (GO:0071675)5.19018225
29negative regulation of peptidyl-serine phosphorylation (GO:0033137)4.96172334
30phosphatidylinositol dephosphorylation (GO:0046856)4.93571084
31regulation of apoptotic cell clearance (GO:2000425)4.86968246
32bone morphogenesis (GO:0060349)4.80893786
33hemidesmosome assembly (GO:0031581)4.73686213
34embryonic hemopoiesis (GO:0035162)4.73407673
35CD4-positive, alpha-beta T cell activation (GO:0035710)4.70182246
36phospholipid dephosphorylation (GO:0046839)4.62447304
37polyol biosynthetic process (GO:0046173)4.60466900
38positive regulation of extracellular matrix organization (GO:1903055)4.55532777
39positive regulation of cellular response to insulin stimulus (GO:1900078)4.47227788
40positive regulation of Rap GTPase activity (GO:0032854)4.46550363
41very-low-density lipoprotein particle assembly (GO:0034379)4.42447925
42positive regulation of ATPase activity (GO:0032781)4.38560960
43positive regulation of ATP catabolic process (GO:1903291)4.38560960
44positive regulation of sodium ion transmembrane transport (GO:1902307)4.33964263
45inositol phosphate-mediated signaling (GO:0048016)4.32826598
46complement activation, alternative pathway (GO:0006957)4.27354534
47regulation of complement activation (GO:0030449)4.24158065
48positive regulation of potassium ion transmembrane transport (GO:1901381)4.09101875
49thyroid hormone generation (GO:0006590)36.8682784
50negative regulation of inclusion body assembly (GO:0090084)3.98550248
51hydrogen peroxide metabolic process (GO:0042743)3.97928412
52regulation of myelination (GO:0031641)3.96559616
53negative regulation of hormone metabolic process (GO:0032351)3.94422143
54negative regulation of hormone biosynthetic process (GO:0032353)3.94422143
55relaxation of muscle (GO:0090075)3.93095185
56regulation of protein activation cascade (GO:2000257)3.91143469
57sodium ion export (GO:0071436)3.89918275
58inositol phosphate metabolic process (GO:0043647)3.83396721
59mitochondrion distribution (GO:0048311)3.81899004
60positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.80404152
61regulation of Rap GTPase activity (GO:0032317)3.78027382
62regulation of extracellular matrix disassembly (GO:0010715)3.77279278
63sequestering of extracellular ligand from receptor (GO:0035581)3.75962791
64regulation of Golgi to plasma membrane protein transport (GO:0042996)3.75838082
65positive regulation of cellular amine metabolic process (GO:0033240)3.74102107
66regulation of phospholipid biosynthetic process (GO:0071071)3.72259074
67receptor recycling (GO:0001881)3.65619484
68regulation of glucocorticoid metabolic process (GO:0031943)3.63229155
69cellular potassium ion homeostasis (GO:0030007)3.60093514
70negative regulation of erythrocyte differentiation (GO:0045647)3.55565976
71inositol metabolic process (GO:0006020)3.54814672
72cerebral cortex neuron differentiation (GO:0021895)3.49646852
73vasodilation (GO:0042311)3.48309379
74regulation of microtubule polymerization (GO:0031113)3.44885335
75positive regulation of positive chemotaxis (GO:0050927)3.43244698
76alanine transport (GO:0032328)3.41366477
77hormone metabolic process (GO:0042445)3.33627225
78hair follicle morphogenesis (GO:0031069)3.31961759
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31312110
80regulation of smooth muscle cell differentiation (GO:0051150)3.30105425
81regulation of positive chemotaxis (GO:0050926)3.29000256
82proline transport (GO:0015824)3.24619764
83sulfur compound transport (GO:0072348)3.21639318
84alpha-beta T cell differentiation (GO:0046632)3.21555322
85regulation of early endosome to late endosome transport (GO:2000641)3.16261431
86regulation of plasminogen activation (GO:0010755)3.13858728
87positive regulation of potassium ion transport (GO:0043268)3.11499879
88adipose tissue development (GO:0060612)3.09979677
89segmentation (GO:0035282)3.09385855
90forebrain neuron differentiation (GO:0021879)3.06406432
91surfactant homeostasis (GO:0043129)3.06313490
92keratan sulfate catabolic process (GO:0042340)3.05469582
93cortical actin cytoskeleton organization (GO:0030866)3.05152926
94import into cell (GO:0098657)3.04803903
95anion homeostasis (GO:0055081)3.03548770
96regulation of calcium ion import (GO:0090279)3.02751681
97glycine transport (GO:0015816)3.01878119
98thyroid hormone metabolic process (GO:0042403)29.8527232
99protein retention in ER lumen (GO:0006621)2.99927481
100cellular response to gonadotropin stimulus (GO:0071371)2.99872988
101Leydig cell differentiation (GO:0033327)2.98621165
102regulation of ATP catabolic process (GO:1903289)2.98127840
103regulation of ATPase activity (GO:0043462)2.98127840
104G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.97432857
105regulation of extracellular matrix organization (GO:1903053)2.92654823
106protein localization to endosome (GO:0036010)2.89594533
107positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.88421794
108mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.87820810
109regulation of sodium ion transmembrane transporter activity (GO:2000649)2.87528398
110endothelial cell chemotaxis (GO:0035767)2.86923815
111positive regulation of vasoconstriction (GO:0045907)2.86733702
112modulation by symbiont of host cellular process (GO:0044068)2.85777956
113negative regulation of glycoprotein biosynthetic process (GO:0010561)2.85481605
114dicarboxylic acid biosynthetic process (GO:0043650)2.84196282
115membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.84031697
116embryonic epithelial tube formation (GO:0001838)2.82508141
117cellular modified amino acid metabolic process (GO:0006575)2.82424751
118activation of MAPKKK activity (GO:0000185)2.80917129
119positive regulation of sodium ion transport (GO:0010765)2.80211281
120iron ion import (GO:0097286)2.76329252
121peptide catabolic process (GO:0043171)2.71458192
122lung secretory cell differentiation (GO:0061140)2.63845355
123sodium ion homeostasis (GO:0055078)2.60003522
124positive regulation of p38MAPK cascade (GO:1900745)2.54126884
125fatty acid derivative transport (GO:1901571)2.53612965
126icosanoid transport (GO:0071715)2.53612965
127arachidonic acid secretion (GO:0050482)2.50006259
128icosanoid secretion (GO:0032309)2.50006259
129membrane repolarization during action potential (GO:0086011)2.47881322
130hypotonic response (GO:0006971)2.45409654
131cellular sodium ion homeostasis (GO:0006883)2.44117508
132cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.40564802
133response to gonadotropin (GO:0034698)2.39267980
134acid secretion (GO:0046717)2.36057741
135regulation of steroid hormone biosynthetic process (GO:0090030)2.32542090
136regulation of hormone biosynthetic process (GO:0046885)2.30958974
137regulation of hormone levels (GO:0010817)2.30826760
138regulation of endothelial cell chemotaxis (GO:2001026)2.29897235
139inorganic anion transport (GO:0015698)2.29833842
140chemical homeostasis within a tissue (GO:0048875)2.29511046
141negative regulation of epithelial to mesenchymal transition (GO:0010719)2.25462469
142epithelial tube branching involved in lung morphogenesis (GO:0060441)2.25313392
143relaxation of cardiac muscle (GO:0055119)2.20763921
144positive regulation of hormone metabolic process (GO:0032352)2.19800879
145cellular response to interferon-alpha (GO:0035457)2.18306885
146lactate metabolic process (GO:0006089)2.16573749
147coronary vasculature morphogenesis (GO:0060977)2.15682735
148positive regulation of endothelial cell apoptotic process (GO:2000353)2.13278311
149negative regulation of bone resorption (GO:0045779)2.12266345
150cortical cytoskeleton organization (GO:0030865)2.10921036
151cellular response to hydrogen peroxide (GO:0070301)2.10689972
152potassium ion import (GO:0010107)2.10484326
153synapse assembly (GO:0007416)2.09935946
154dopaminergic neuron differentiation (GO:0071542)2.09630044
155positive regulation of vascular permeability (GO:0043117)2.09182019
156positive regulation of histone deacetylation (GO:0031065)2.07832493
157lung vasculature development (GO:0060426)2.07084072
158regulation of hormone metabolic process (GO:0032350)2.05700728
159positive regulation of protein kinase C signaling (GO:0090037)2.04161267
160negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.03563340
161cellular response to vitamin D (GO:0071305)13.7299952
162response to lipoprotein particle (GO:0055094)12.8917211
163thyroid gland development (GO:0030878)12.0335287
164cellular response to vitamin (GO:0071295)11.0910552
165cellular response to hepatocyte growth factor stimulus (GO:0035729)10.7947415
166response to hepatocyte growth factor (GO:0035728)10.7947415
167phosphate ion homeostasis (GO:0055062)10.3405105
168trivalent inorganic anion homeostasis (GO:0072506)10.3405105
169cell communication by electrical coupling (GO:0010644)1.99885042
170cell-substrate junction assembly (GO:0007044)1.99250726
171regulation of clathrin-mediated endocytosis (GO:2000369)1.96168394
172positive regulation of hormone biosynthetic process (GO:0046886)1.94938939
173thymus development (GO:0048538)1.94008469
174outer ear morphogenesis (GO:0042473)1.91703818
175sequestering of metal ion (GO:0051238)1.91472543
176positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)1.91430647
177mesenchymal to epithelial transition (GO:0060231)1.90495404
178regulation of chemokine-mediated signaling pathway (GO:0070099)1.90140339
179regulation of p38MAPK cascade (GO:1900744)1.89876515
180cell communication involved in cardiac conduction (GO:0086065)1.88380212
181vascular endothelial growth factor signaling pathway (GO:0038084)1.88169561
182membrane repolarization (GO:0086009)1.87623050
183adhesion of symbiont to host cell (GO:0044650)1.85931009
184virion attachment to host cell (GO:0019062)1.85931009
185developmental induction (GO:0031128)1.84942865
186cell migration involved in sprouting angiogenesis (GO:0002042)1.84597492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons4.29945330
2ESR2_21235772_ChIP-Seq_MCF-7_Human3.60097419
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.46588654
4NFIB_24661679_ChIP-Seq_LUNG_Mouse3.23934516
5DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.18645900
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.15122970
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.81105227
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63767919
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.56975222
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56746098
11CLOCK_20551151_ChIP-Seq_293T_Human2.52060916
12MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.46990126
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.44645513
14GATA3_24758297_ChIP-Seq_MCF-7_Human2.18770452
15AR_21909140_ChIP-Seq_LNCAP_Human2.17461328
16GATA3_20176728_ChIP-ChIP_TSCs_Mouse2.04286796
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03921748
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02951525
19PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00638892
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse12.0729908
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.99523989
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94872048
23KLF5_25053715_ChIP-Seq_YYC3_Human1.89496134
24RACK7_27058665_Chip-Seq_MCF-7_Human1.85853128
25DROSHA_22980978_ChIP-Seq_HELA_Human1.84938384
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.83270222
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.82616522
28TP53_16413492_ChIP-PET_HCT116_Human1.78135920
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76352731
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75811245
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74995263
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.73934231
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.72510233
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.72482720
35EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.72011204
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65553669
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.61279209
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60677022
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59567677
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57517385
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54914633
42SOX2_20726797_ChIP-Seq_SW620_Human1.53214647
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.52997986
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.52461191
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49393140
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46383886
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46333904
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.44378189
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43839223
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42558570
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.42429348
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42050705
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41932093
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41910069
55AHR_22903824_ChIP-Seq_MCF-7_Human1.41792132
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40158026
57SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38804140
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35118334
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35075861
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34933407
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34207409
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32707889
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31269376
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.31175339
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.29294723
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29023365
67LXR_22292898_ChIP-Seq_THP-1_Human1.27359116
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27248462
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26926234
70KDM2B_26808549_Chip-Seq_K562_Human1.26209629
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26064583
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.25314705
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24061346
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23728589
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22558848
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22414674
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21948391
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.21782612
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21761597
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21335404
81ELK4_26923725_Chip-Seq_MESODERM_Mouse1.20841146
82* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19946436
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.19733722
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16993470
85GF1_26923725_Chip-Seq_HPCs_Mouse1.16415143
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.15547658
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14772442
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.14435136
89TBX20_22080862_ChIP-Seq_HEART_Mouse1.14435136
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14316633
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13960980
92CJUN_26792858_Chip-Seq_BT549_Human1.13612756
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12494438
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11096917
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10413761
96CTCF_27219007_Chip-Seq_Bcells_Human1.09638705
97RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09537342
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09537342
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08225894
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06640523
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06594027
102SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06487518
103TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.05722397
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.05160959
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04477736
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04367314
107LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03974592
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03417704
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03133075
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02546491
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.02449444
112GATA1_22025678_ChIP-Seq_K562_Human1.01634830
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.01195572
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00814790
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00814790
116P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00080021
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99648261
118CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99579944
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99164841
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97915331
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97709854
122P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97175821
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.96671393
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95748092
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94828961
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94615736
127* TFEB_21752829_ChIP-Seq_HELA_Human0.94130106
128ZNF263_19887448_ChIP-Seq_K562_Human0.94097764
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94092710
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93393401
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93159268
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93106866
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.92715590
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92393508
135JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92262217
136CTCF_21964334_Chip-Seq_Bcells_Human0.91715650
137RING1B_27294783_Chip-Seq_ESCs_Mouse0.91500498
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.90998716
139CREB1_26743006_Chip-Seq_LNCaP_Human0.90796769
140TP63_22573176_ChIP-Seq_HFKS_Human0.90258951
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.90129750
142CHD1_26751641_Chip-Seq_LNCaP_Human0.89845424
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89623423
144KDM2B_26808549_Chip-Seq_DND41_Human0.89590875
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89111508
146RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89103024
147TET1_21490601_ChIP-Seq_MESCs_Mouse0.86319466
148SOX11_22085726_ChIP-Seq_ESNs_Mouse0.86162339
149TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84593870
150STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81497598
151GATA4_25053715_ChIP-Seq_YYC3_Human0.78654364
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78115288
153KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76483349
154* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.74455001
155GATA2_19941826_ChIP-Seq_K562_Human0.72683463
156SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.71109146
157NANOG_16518401_ChIP-PET_MESCs_Mouse0.69475126
158FOXA1_25552417_ChIP-Seq_VCAP_Human0.68985712
159TCF3_18692474_ChIP-Seq_MESCs_Mouse0.68525754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000383_abnormal_hair_follicle7.79699730
2MP0010678_abnormal_skin_adnexa6.54330698
3MP0004043_abnormal_pH_regulation5.56381782
4MP0000516_abnormal_urinary_system5.49140816
5MP0005367_renal/urinary_system_phenotyp5.49140816
6MP0002909_abnormal_adrenal_gland4.40617072
7MP0002938_white_spotting3.52049775
8MP0002876_abnormal_thyroid_physiology3.26349074
9MP0010234_abnormal_vibrissa_follicle2.56101076
10MP0002168_other_aberrant_phenotype2.49926117
11MP0004084_abnormal_cardiac_muscle2.33768895
12MP0001958_emphysema2.07722250
13MP0000733_abnormal_muscle_development2.04871311
14MP0002234_abnormal_pharynx_morphology2.01524966
15MP0000681_abnormal_thyroid_gland11.2997728
16MP0003172_abnormal_lysosome_physiology1.94144637
17MP0004036_abnormal_muscle_relaxation1.79166698
18MP0008995_early_reproductive_senescence1.75112204
19MP0000462_abnormal_digestive_system1.73805075
20MP0002108_abnormal_muscle_morphology1.69384505
21MP0009840_abnormal_foam_cell1.61394837
22MP0009780_abnormal_chondrocyte_physiolo1.54801478
23MP0000566_synostosis1.51253800
24MP0004272_abnormal_basement_membrane1.51242003
25MP0004215_abnormal_myocardial_fiber1.50989168
26MP0003566_abnormal_cell_adhesion1.48770364
27MP0005381_digestive/alimentary_phenotyp1.45617486
28MP0003868_abnormal_feces_composition1.45541249
29MP0003075_altered_response_to1.44234520
30MP0005395_other_phenotype1.38346993
31MP0000920_abnormal_myelination1.35527520
32MP0003186_abnormal_redox_activity1.35196260
33MP0010771_integument_phenotype1.34223790
34MP0000537_abnormal_urethra_morphology1.32349490
35MP0002254_reproductive_system_inflammat1.32215705
36MP0001663_abnormal_digestive_system1.31462621
37MP0005584_abnormal_enzyme/coenzyme_acti1.31454225
38MP0004019_abnormal_vitamin_homeostasis1.30145332
39MP0008438_abnormal_cutaneous_collagen1.28043366
40MP0005058_abnormal_lysosome_morphology1.27368874
41MP0003191_abnormal_cellular_cholesterol1.25080472
42MP0009643_abnormal_urine_homeostasis1.22892861
43MP0002932_abnormal_joint_morphology1.19321809
44MP0003950_abnormal_plasma_membrane1.17328572
45MP0001346_abnormal_lacrimal_gland1.15221107
46* MP0000678_abnormal_parathyroid_gland1.15145527
47MP0003436_decreased_susceptibility_to1.12755725
48MP0000569_abnormal_digit_pigmentation1.12344777
49MP0009053_abnormal_anal_canal1.11640094
50MP0005666_abnormal_adipose_tissue1.10088387
51MP0001756_abnormal_urination1.06894162
52MP0001849_ear_inflammation1.05440167
53MP0003303_peritoneal_inflammation1.04675555
54MP0000534_abnormal_ureter_morphology1.01763985
55* MP0002896_abnormal_bone_mineralization1.01530183
56MP0002796_impaired_skin_barrier0.99693677
57MP0003633_abnormal_nervous_system0.97690840
58MP0000747_muscle_weakness0.96507140
59MP0001348_abnormal_lacrimal_gland0.96034993
60* MP0009250_abnormal_appendicular_skeleto0.94921265
61MP0008775_abnormal_heart_ventricle0.93918709
62MP0003656_abnormal_erythrocyte_physiolo0.93755255
63MP0000762_abnormal_tongue_morphology0.91077036
64MP0010030_abnormal_orbit_morphology0.89765331
65MP0003879_abnormal_hair_cell0.89107137
66MP0002098_abnormal_vibrissa_morphology0.86028225
67* MP0003795_abnormal_bone_structure0.83986107
68MP0005165_increased_susceptibility_to0.81845972
69MP0003638_abnormal_response/metabolism_0.79404640
70MP0005501_abnormal_skin_physiology0.78834251
71* MP0002113_abnormal_skeleton_development0.78456978
72MP0002060_abnormal_skin_morphology0.77680855
73* MP0005508_abnormal_skeleton_morphology0.75908891
74MP0002971_abnormal_brown_adipose0.72377896
75MP0004782_abnormal_surfactant_physiolog0.71480123
76MP0000377_abnormal_hair_follicle0.68810701
77MP0003329_amyloid_beta_deposits0.68725165
78MP0001879_abnormal_lymphatic_vessel0.68542182
79MP0003755_abnormal_palate_morphology0.68171521
80MP0005166_decreased_susceptibility_to0.65836108
81MP0003137_abnormal_impulse_conducting0.65043098
82MP0005023_abnormal_wound_healing0.64669238
83MP0002735_abnormal_chemical_nociception0.64238077
84MP0003453_abnormal_keratinocyte_physiol0.63902862
85MP0008961_abnormal_basal_metabolism0.63696931
86MP0006054_spinal_hemorrhage0.62503700
87MP0004885_abnormal_endolymph0.61962253
88MP0002089_abnormal_postnatal_growth/wei0.61256324
89MP0002295_abnormal_pulmonary_circulatio0.60145490
90MP0003183_abnormal_peptide_metabolism0.59834018
91MP0009384_cardiac_valve_regurgitation0.59808397
92MP0003938_abnormal_ear_development0.59489417
93MP0004185_abnormal_adipocyte_glucose0.58509765
94MP0003119_abnormal_digestive_system0.57947947
95MP0003786_premature_aging0.57209130
96MP0003953_abnormal_hormone_level0.56606579
97MP0001765_abnormal_ion_homeostasis0.56313692
98* MP0005390_skeleton_phenotype0.55170526
99MP0009333_abnormal_splenocyte_physiolog0.54408524
100* MP0000163_abnormal_cartilage_morphology0.54333470
101MP0002972_abnormal_cardiac_muscle0.53731042
102MP0001270_distended_abdomen0.52459252
103MP0002136_abnormal_kidney_physiology0.52124091
104MP0004484_altered_response_of0.52035870
105MP0003935_abnormal_craniofacial_develop0.51254226
106MP0005375_adipose_tissue_phenotype0.51136012
107MP0005636_abnormal_mineral_homeostasis0.50567344
108MP0002282_abnormal_trachea_morphology0.49697694
109MP0000358_abnormal_cell_content/0.49618332
110MP0002877_abnormal_melanocyte_morpholog0.49330094
111MP0004264_abnormal_extraembryonic_tissu0.49103170
112MP0003631_nervous_system_phenotype0.48434664
113MP0004130_abnormal_muscle_cell0.48201577
114MP0005623_abnormal_meninges_morphology0.47959993
115MP0001440_abnormal_grooming_behavior0.47802949
116MP0001915_intracranial_hemorrhage0.47735463
117MP0003448_altered_tumor_morphology0.46955669
118MP0000538_abnormal_urinary_bladder0.45741376
119MP0003878_abnormal_ear_physiology0.44747757
120MP0005377_hearing/vestibular/ear_phenot0.44747757
121MP0005647_abnormal_sex_gland0.44711852
122MP0008004_abnormal_stomach_pH0.44617158
123MP0003705_abnormal_hypodermis_morpholog0.44548376
124MP0003091_abnormal_cell_migration0.44102976
125MP0003115_abnormal_respiratory_system0.43230717
126MP0006138_congestive_heart_failure0.42721612
127MP0003300_gastrointestinal_ulcer0.41552522
128MP0005319_abnormal_enzyme/_coenzyme0.41215526
129MP0008875_abnormal_xenobiotic_pharmacok0.40592467
130MP0004858_abnormal_nervous_system0.40590410
131MP0005275_abnormal_skin_tensile0.40399340
132MP0003942_abnormal_urinary_system0.39651732
133MP0000428_abnormal_craniofacial_morphol0.39638663
134MP0006072_abnormal_retinal_apoptosis0.38160949
135MP0003195_calcinosis0.37894109
136MP0002332_abnormal_exercise_endurance0.37679692
137MP0006036_abnormal_mitochondrial_physio0.37041453
138MP0009764_decreased_sensitivity_to0.35860145
139MP0005310_abnormal_salivary_gland0.35534831
140MP0002115_abnormal_skeleton_extremities0.35372261
141MP0000467_abnormal_esophagus_morphology0.35264103
142MP0002135_abnormal_kidney_morphology0.35210068
143MP0000604_amyloidosis0.35060011
144MP0001501_abnormal_sleep_pattern0.34127218
145MP0005620_abnormal_muscle_contractility0.33372811
146MP0001191_abnormal_skin_condition0.32759807
147MP0001533_abnormal_skeleton_physiology0.31847247
148MP0000343_altered_response_to0.31422977
149MP0002653_abnormal_ependyma_morphology0.30994628
150* MP0002116_abnormal_craniofacial_bone0.30526759
151MP0000778_abnormal_nervous_system0.28445553
152MP0002111_abnormal_tail_morphology0.28256477
153MP0000465_gastrointestinal_hemorrhage0.27420868
154MP0005365_abnormal_bile_salt0.26982668
155MP0009763_increased_sensitivity_to0.26236898
156MP0004381_abnormal_hair_follicle0.25995346
157MP0003283_abnormal_digestive_organ0.25792863
158MP0005409_darkened_coat_color0.24986526
159MP0002085_abnormal_embryonic_tissue0.24396889
160MP0001731_abnormal_postnatal_growth0.23307971
161MP0005369_muscle_phenotype0.22824898
162MP0002063_abnormal_learning/memory/cond0.22100162
163MP0002138_abnormal_hepatobiliary_system0.21903142
164MP0001216_abnormal_epidermal_layer0.21673222
165MP0005535_abnormal_body_temperature0.20996341

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)9.42464363
2Abnormal hair laboratory examination (HP:0003328)9.14023286
3Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)8.93626000
4Increased circulating renin level (HP:0000848)8.23510998
5Alacrima (HP:0000522)7.55216858
6J-shaped sella turcica (HP:0002680)7.08870865
7Metaphyseal irregularity (HP:0003025)6.63397834
8Conjugated hyperbilirubinemia (HP:0002908)6.58852993
9Vacuolated lymphocytes (HP:0001922)6.52351846
10Decreased lacrimation (HP:0000633)6.21060191
11Microretrognathia (HP:0000308)6.11026683
12Onycholysis (HP:0001806)6.05720718
13Nasolacrimal duct obstruction (HP:0000579)5.65033740
14Thyroid carcinoma (HP:0002890)5.11514061
15Hypothyroidism (HP:0000821)4.90104396
16Mixed hearing impairment (HP:0000410)4.81700734
17* Hypoparathyroidism (HP:0000829)4.61571182
18* Hypocalcemia (HP:0002901)4.58588910
19Hyperparathyroidism (HP:0000843)4.53153411
20Abnormality of the lacrimal duct (HP:0011481)4.45792006
21Preauricular pit (HP:0004467)4.41594289
22Periauricular skin pits (HP:0100277)4.41594289
23Hypomagnesemia (HP:0002917)4.25674259
24Cervical subluxation (HP:0003308)4.22501784
25Coarse facial features (HP:0000280)4.08441970
26Deformed sella turcica (HP:0002681)4.07625464
27Fair hair (HP:0002286)3.90854084
28Abnormality of the nasolacrimal system (HP:0000614)3.87846349
29Abnormal drinking behavior (HP:0030082)3.64789976
30Polydipsia (HP:0001959)3.64789976
31Abnormality of magnesium homeostasis (HP:0004921)3.64623105
32Urinary glycosaminoglycan excretion (HP:0003541)3.61943900
33Mucopolysacchariduria (HP:0008155)3.61943900
34Ulnar deviation of the wrist (HP:0003049)3.50518476
35Delayed CNS myelination (HP:0002188)3.45323657
36Vascular calcification (HP:0004934)3.37680292
37Scapular winging (HP:0003691)3.36533528
38Constipation (HP:0002019)3.31820223
39Generalized hypopigmentation of hair (HP:0011358)3.30133348
40Abnormality of polysaccharide metabolism (HP:0011012)3.27080285
41Abnormality of glycosaminoglycan metabolism (HP:0004371)3.27080285
42Abnormality of mucopolysaccharide metabolism (HP:0011020)3.27080285
43Intellectual disability, moderate (HP:0002342)3.17748900
44Hyperactive renin-angiotensin system (HP:0000841)3.16576209
45Athetosis (HP:0002305)3.12398327
46Skin pits (HP:0100276)3.08942436
47Thickened calvaria (HP:0002684)3.01381585
48Cardiovascular calcification (HP:0011915)3.00186933
49Exotropia (HP:0000577)2.99162526
50Neonatal respiratory distress (HP:0002643)2.92557847
51Milia (HP:0001056)2.85634042
52Abnormality of renal excretion (HP:0011036)2.83833709
53Disproportionate short-trunk short stature (HP:0003521)2.78933617
54Atrophic scars (HP:0001075)2.74501892
55Basal ganglia calcification (HP:0002135)2.73922551
56Hyperpituitarism (HP:0010514)2.73628008
57Tachypnea (HP:0002789)2.71289525
58Abnormality of the sella turcica (HP:0002679)2.69414094
59Hypoplasia of the odontoid process (HP:0003311)2.67489431
60Muscle fiber splitting (HP:0003555)2.66935764
61Fragile nails (HP:0001808)2.62357537
62Neoplasm of the thyroid gland (HP:0100031)2.62132167
63Split foot (HP:0001839)2.61048143
64Hyperphosphaturia (HP:0003109)2.59863093
65Partial duplication of thumb phalanx (HP:0009944)2.41224329
66Nephrocalcinosis (HP:0000121)2.39895623
67Polyuria (HP:0000103)2.38209651
68Abnormality of the dental root (HP:0006486)2.33912595
69Taurodontia (HP:0000679)2.33912595
70Abnormality of permanent molar morphology (HP:0011071)2.33912595
71Inability to walk (HP:0002540)2.31725248
72Hypokalemia (HP:0002900)2.30869959
73Death in childhood (HP:0003819)2.28420133
74Abnormality of the odontoid process (HP:0003310)2.24375153
75Hypercalciuria (HP:0002150)2.23418533
76Hypophosphatemia (HP:0002148)2.22753154
77Broad metatarsal (HP:0001783)2.20628493
78Abnormality of molar morphology (HP:0011070)2.18703776
79Abnormality of molar (HP:0011077)2.18703776
80Abnormal urine phosphate concentration (HP:0012599)2.17471388
81Chronic bronchitis (HP:0004469)2.13461680
82Umbilical hernia (HP:0001537)2.13133278
83Partial duplication of the phalanx of hand (HP:0009999)2.12361610
84Bronchomalacia (HP:0002780)2.09012973
85Urethral obstruction (HP:0000796)2.08593110
86Abnormality of the dental pulp (HP:0006479)2.05012085
87Goiter (HP:0000853)16.0265090
88Pili torti (HP:0003777)14.6473370
89* Hyperphosphatemia (HP:0002905)14.1191512
90* Tetany (HP:0001281)13.4728981
91Abnormality of calcium-phosphate metabolism (HP:0100530)10.2483604
92Thyroid-stimulating hormone excess (HP:0002925)10.0322227
93Obstructive sleep apnea (HP:0002870)1.99470147
94Right ventricular cardiomyopathy (HP:0011663)1.98645042
95Ovoid vertebral bodies (HP:0003300)1.96535691
96Sprengel anomaly (HP:0000912)1.96190369
97Abnormality of the shoulder girdle musculature (HP:0001435)1.95987777
98Upper limb amyotrophy (HP:0009129)1.95132253
99Distal upper limb amyotrophy (HP:0007149)1.95132253
100Oral leukoplakia (HP:0002745)1.94367766
101Abnormal urine output (HP:0012590)1.93446003
102Aplastic anemia (HP:0001915)1.92297277
103Difficulty running (HP:0009046)1.91708363
104Hypercalcemia (HP:0003072)1.90735607
105Generalized amyotrophy (HP:0003700)1.89186524
106Abnormality of the antihelix (HP:0009738)1.88876056
107Asymmetry of the thorax (HP:0001555)1.86664121
108Flat acetabular roof (HP:0003180)1.85578552
109Scanning speech (HP:0002168)1.83820508
110Resting tremor (HP:0002322)1.83767435
111Tapered finger (HP:0001182)1.79850205
112Limb-girdle muscle atrophy (HP:0003797)1.79274397
113Lower limb asymmetry (HP:0100559)1.78768874
114Thin bony cortex (HP:0002753)1.75995685
115Abnormality of intracranial pressure (HP:0012640)1.74663208
116Increased intracranial pressure (HP:0002516)1.74663208
117Difficulty climbing stairs (HP:0003551)1.73351921
118Type I diabetes mellitus (HP:0100651)1.72424930
119Abnormal hemoglobin (HP:0011902)1.71363699
120Abnormality of the distal phalanges of the toes (HP:0010182)1.70219235
121Stridor (HP:0010307)1.67221622
122Abnormality of renal resorption (HP:0011038)1.66695713
123Hand muscle atrophy (HP:0009130)1.64119731
124Rough bone trabeculation (HP:0100670)1.62903483
125Hypotension (HP:0002615)1.61222626
126Respiratory distress (HP:0002098)1.61136699
127Abnormality of potassium homeostasis (HP:0011042)1.59604575
128Neurofibrillary tangles (HP:0002185)1.58373126
129Atresia of the external auditory canal (HP:0000413)1.58334815
130Increased connective tissue (HP:0009025)1.57568116
131Deep venous thrombosis (HP:0002625)1.56845582
132Menstrual irregularities (HP:0000858)1.54954113
133Nonprogressive disorder (HP:0003680)1.54058031
134Abnormality of chloride homeostasis (HP:0011422)1.53833089
135Distal lower limb muscle weakness (HP:0009053)1.51535382
136Vaginal fistula (HP:0004320)1.50567745
137Sleep apnea (HP:0010535)1.49407941
138Hyperkalemia (HP:0002153)1.48502040
139Achilles tendon contracture (HP:0001771)1.47856896
140Cardiomegaly (HP:0001640)1.47853380
141Blue sclerae (HP:0000592)1.47817853
142Hypoplasia of dental enamel (HP:0006297)1.47025756
143Chronic otitis media (HP:0000389)1.46908530
144Back pain (HP:0003418)1.46709176
145Bifid scrotum (HP:0000048)1.46439202
146Cerebral inclusion bodies (HP:0100314)1.46394273
147Abnormality of the middle phalanges of the toes (HP:0010183)1.45904451
148Aplasia of the musculature (HP:0100854)1.45677540
149Increased density of long bones (HP:0006392)1.44095528
150Pancreatitis (HP:0001733)1.43494948
151Abnormality of the Achilles tendon (HP:0005109)1.42463364
152Renal salt wasting (HP:0000127)1.41891965
153Macroglossia (HP:0000158)1.41254913
154Decreased circulating renin level (HP:0003351)1.40736702
155Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.40267911
156Hyperaldosteronism (HP:0000859)1.40109402
157Thoracolumbar scoliosis (HP:0002944)1.39764641
158Hyperbilirubinemia (HP:0002904)1.38438655
159Abnormality of the vocal cords (HP:0008777)1.38402898
160Shallow orbits (HP:0000586)1.36797210
161Diaphragmatic weakness (HP:0009113)1.35348859
162Choanal atresia (HP:0000453)1.35074762
163Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.34735830
164Abnormality of the basal ganglia (HP:0002134)1.33105282
165Rectal fistula (HP:0100590)1.32935527
166Rectovaginal fistula (HP:0000143)1.32935527
167Plantar hyperkeratosis (HP:0007556)1.32348252
168Ankle contracture (HP:0006466)1.30931217
169Abnormality of renin-angiotensin system (HP:0000847)1.30645513
170Hypoplastic nipples (HP:0002557)1.28943605
171Premature skin wrinkling (HP:0100678)1.28762737
172Tetraparesis (HP:0002273)1.28233046
173Spinal muscular atrophy (HP:0007269)1.26219261
174Abnormality of monocarboxylic acid metabolism (HP:0010996)1.25425326
175Increased variability in muscle fiber diameter (HP:0003557)1.23989309
176Anxiety (HP:0000739)1.23813867
177Nail dystrophy (HP:0008404)1.22827148
178Enlarged epiphyses (HP:0010580)1.22177391
179Rickets (HP:0002748)1.22001329
180Abnormality of the calf musculature (HP:0001430)1.21672915
181Abnormal vertebral ossification (HP:0100569)1.21622212
182Proximal amyotrophy (HP:0007126)1.21276183
183Hallux valgus (HP:0001822)1.20268804
184Azoospermia (HP:0000027)1.19819335
185Hyperthyroidism (HP:0000836)1.19502577
186Intrahepatic cholestasis (HP:0001406)1.19348712
187Symptomatic seizures (HP:0011145)1.18920604
188Delayed eruption of teeth (HP:0000684)1.15179831
189Full cheeks (HP:0000293)1.14917365
190Increased serum ferritin (HP:0003281)1.14858350
191Abnormal trabecular bone morphology (HP:0100671)1.12853649
192Gonadotropin excess (HP:0000837)1.10675757
193Delayed epiphyseal ossification (HP:0002663)1.08808616
194Abnormality of the costochondral junction (HP:0000919)1.06152167
195Nephrolithiasis (HP:0000787)0.99307727
196Gingival overgrowth (HP:0000212)0.98336983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK28.84440166
2TRIB34.53403878
3DAPK24.00212240
4MST43.52038784
5FGFR22.82464783
6ERBB32.78753888
7ERN12.76646971
8NEK62.72668318
9EPHB12.67493841
10MAP3K122.34650951
11FER2.21051524
12LRRK22.13935422
13SMG12.11476447
14PAK42.05274042
15RET2.05143840
16RIPK12.02367469
17MAP3K310.2317333
18KSR21.96913676
19TRPM71.93198219
20AKT31.92910382
21PTK61.86088566
22NTRK11.83952488
23MAP3K21.81065825
24PRKD31.77818545
25SIK11.76230651
26NEK11.76099884
27DAPK11.69399563
28PKN21.63920937
29PAK31.59468179
30DYRK1A1.58048627
31LMTK21.56532889
32MAPK71.54828518
33PRKCG1.54113945
34MAPK121.52895742
35MYLK1.49618527
36MAP2K21.48098353
37STK38L1.45167205
38PTK21.43034201
39TESK11.32253988
40EPHB21.31052984
41MAP2K11.30867343
42DAPK31.26054424
43BCR1.25617375
44CLK11.16941478
45TTN1.16890542
46PHKG21.16737011
47PHKG11.16737011
48FGFR41.13036350
49GSK3A1.07976853
50MAPK151.07392594
51MAP3K91.05980271
52DDR21.02942441
53EIF2AK11.02245470
54TBK10.93899707
55PRKD20.91719819
56ICK0.91286996
57CAMK1D0.89512676
58STK240.88468784
59RPS6KA20.87147591
60JAK20.86393312
61STK100.86075497
62MATK0.84614294
63ILK0.83356256
64PAK60.82112928
65FGFR10.80976775
66PRKCI0.78553275
67ROCK20.77479560
68FRK0.76836346
69CAMK1G0.74232096
70PTK2B0.73652337
71BCKDK0.72848306
72EPHA40.68466568
73MAPKAPK50.64295107
74MAP3K70.64175106
75SCYL20.62747784
76PDK10.61370229
77SRC0.59005709
78PDGFRA0.58850587
79EPHA20.58427457
80PRKD10.57886439
81PRKCZ0.55923408
82PDK40.55493517
83PDK30.55493517
84MKNK10.54745392
85LATS20.54482726
86LATS10.54264799
87CAMKK10.53149478
88EPHA30.52828093
89AKT20.52206746
90LIMK10.50490769
91PINK10.49011036
92MAP3K10.48218674
93PIK3CA0.47513417
94CAMKK20.46620466
95MAP2K60.45315691
96TYRO30.45023026
97KDR0.44925984
98CSNK1A10.44858618
99MTOR0.44019565
100ITK0.43692029
101PRKCH0.43343742
102EGFR0.42639941
103PDPK10.42427925
104STK390.41858326
105IRAK30.40505569
106MARK20.40281261
107TAOK10.40055882
108STK30.39196415
109FYN0.38405812
110JAK10.37922212
111STK380.37857461
112ROCK10.37640462
113MAP3K130.37442843
114ADRBK10.37404599
115NLK0.36458266
116MAP3K60.36210159
117RIPK40.36047647
118CSNK1E0.35654686
119MAP3K100.33471496
120MAP3K140.32977850
121UHMK10.32858415
122FGR0.32347131
123CSK0.32218824
124MET0.31872332
125INSR0.31552608
126MAP3K80.31217093
127CDK50.30849116
128ERBB20.30462207
129HIPK20.30171870
130PAK20.30000352
131CSNK1A1L0.29818144
132TGFBR20.29422927
133FGFR30.29311263
134PAK10.28808490
135MAPK40.28424595
136PIM20.27498701
137BTK0.27427127
138MAPK30.26861209
139YES10.25954283
140SGK30.24506155
141MAPK10.23331955
142PRKCB0.22731674
143PRKAA10.22546252
144NEK90.18737595
145PRKCA0.18452801
146MAP2K40.18256392
147PRKAA20.17473863
148ARAF0.16389480
149IRAK20.15794639
150CSNK1D0.13679160
151STK110.13253273
152MAPK140.10650413
153PRKCQ0.10576332

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid hormone synthesis_Homo sapiens_hsa049186.40873864
2Inositol phosphate metabolism_Homo sapiens_hsa005624.70960594
3Fatty acid biosynthesis_Homo sapiens_hsa000614.15136262
4Tyrosine metabolism_Homo sapiens_hsa003503.11484543
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.19114580
6Gastric acid secretion_Homo sapiens_hsa049712.06281725
7Autoimmune thyroid disease_Homo sapiens_hsa0532010.5827411
8Complement and coagulation cascades_Homo sapiens_hsa046101.98280227
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94504849
10Sulfur metabolism_Homo sapiens_hsa009201.81984498
11Mineral absorption_Homo sapiens_hsa049781.63132654
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62477496
13Fatty acid metabolism_Homo sapiens_hsa012121.61812987
14Staphylococcus aureus infection_Homo sapiens_hsa051501.59674947
15Bile secretion_Homo sapiens_hsa049761.41104076
16Renin-angiotensin system_Homo sapiens_hsa046141.11552770
17Starch and sucrose metabolism_Homo sapiens_hsa005001.10249584
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.07294525
19ECM-receptor interaction_Homo sapiens_hsa045121.03342436
20Thyroid cancer_Homo sapiens_hsa052160.98944677
21Lysosome_Homo sapiens_hsa041420.97286217
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92868411
23Amoebiasis_Homo sapiens_hsa051460.91072326
24Insulin secretion_Homo sapiens_hsa049110.89222235
25Arginine biosynthesis_Homo sapiens_hsa002200.87759017
26Steroid biosynthesis_Homo sapiens_hsa001000.87287254
27Bladder cancer_Homo sapiens_hsa052190.86801005
28Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85794154
29VEGF signaling pathway_Homo sapiens_hsa043700.82715496
30PPAR signaling pathway_Homo sapiens_hsa033200.81437160
31Long-term depression_Homo sapiens_hsa047300.78887253
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78839545
33Small cell lung cancer_Homo sapiens_hsa052220.74813547
34Platelet activation_Homo sapiens_hsa046110.74512469
35Fatty acid elongation_Homo sapiens_hsa000620.74480937
36Vibrio cholerae infection_Homo sapiens_hsa051100.72870627
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70900194
38Focal adhesion_Homo sapiens_hsa045100.70202096
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69265171
40Other glycan degradation_Homo sapiens_hsa005110.65542778
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65121010
42Dorso-ventral axis formation_Homo sapiens_hsa043200.64461450
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63451019
44Antigen processing and presentation_Homo sapiens_hsa046120.63433456
45Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62767557
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62245312
47Renal cell carcinoma_Homo sapiens_hsa052110.61964007
48Salivary secretion_Homo sapiens_hsa049700.59283990
49Estrogen signaling pathway_Homo sapiens_hsa049150.58807131
50Endocytosis_Homo sapiens_hsa041440.57564909
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.56959531
52Proteoglycans in cancer_Homo sapiens_hsa052050.55108715
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54506602
54mTOR signaling pathway_Homo sapiens_hsa041500.54173241
55Renin secretion_Homo sapiens_hsa049240.53342114
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53226735
57Melanogenesis_Homo sapiens_hsa049160.53010621
58Fatty acid degradation_Homo sapiens_hsa000710.52031410
59Circadian rhythm_Homo sapiens_hsa047100.51578727
60Glioma_Homo sapiens_hsa052140.50364026
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.49631787
62AMPK signaling pathway_Homo sapiens_hsa041520.49541192
63Linoleic acid metabolism_Homo sapiens_hsa005910.49203894
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49132802
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48648678
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48503396
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.48280676
68Toxoplasmosis_Homo sapiens_hsa051450.47359222
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45684106
70Pyruvate metabolism_Homo sapiens_hsa006200.45461701
71Protein digestion and absorption_Homo sapiens_hsa049740.45166675
72Peroxisome_Homo sapiens_hsa041460.45075440
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44118154
74Long-term potentiation_Homo sapiens_hsa047200.43903439
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43675210
76Sphingolipid metabolism_Homo sapiens_hsa006000.43017595
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42482541
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.40807377
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40332060
80Tight junction_Homo sapiens_hsa045300.40248667
81Glutamatergic synapse_Homo sapiens_hsa047240.39796253
82Amphetamine addiction_Homo sapiens_hsa050310.39549496
83p53 signaling pathway_Homo sapiens_hsa041150.39178767
84Prion diseases_Homo sapiens_hsa050200.38970078
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.38123863
86Fat digestion and absorption_Homo sapiens_hsa049750.37266891
87FoxO signaling pathway_Homo sapiens_hsa040680.36791158
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36307579
89Insulin resistance_Homo sapiens_hsa049310.36110353
90Collecting duct acid secretion_Homo sapiens_hsa049660.35003988
91Selenocompound metabolism_Homo sapiens_hsa004500.34827967
92GnRH signaling pathway_Homo sapiens_hsa049120.34415625
93Nitrogen metabolism_Homo sapiens_hsa009100.33090834
94Glucagon signaling pathway_Homo sapiens_hsa049220.32071450
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32007013
96Hippo signaling pathway_Homo sapiens_hsa043900.31879278
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31821440
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30953380
99Pancreatic secretion_Homo sapiens_hsa049720.30438179
100Tuberculosis_Homo sapiens_hsa051520.30247958
101Circadian entrainment_Homo sapiens_hsa047130.29583866
102Endometrial cancer_Homo sapiens_hsa052130.29533422
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29513485
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28969071
105Pertussis_Homo sapiens_hsa051330.28923154
106Insulin signaling pathway_Homo sapiens_hsa049100.27859635
107Pathways in cancer_Homo sapiens_hsa052000.27369704
108cAMP signaling pathway_Homo sapiens_hsa040240.27056754
109Oxytocin signaling pathway_Homo sapiens_hsa049210.26734944
110Olfactory transduction_Homo sapiens_hsa047400.26508186
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26384191
112Rap1 signaling pathway_Homo sapiens_hsa040150.26220603
113Dopaminergic synapse_Homo sapiens_hsa047280.26066010
114Propanoate metabolism_Homo sapiens_hsa006400.25927452
115Hepatitis C_Homo sapiens_hsa051600.25587672
116HIF-1 signaling pathway_Homo sapiens_hsa040660.24814644
117Apoptosis_Homo sapiens_hsa042100.24055696
118Pancreatic cancer_Homo sapiens_hsa052120.23567268
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22958845
120Adherens junction_Homo sapiens_hsa045200.22776829
121Gap junction_Homo sapiens_hsa045400.22396594
122Ras signaling pathway_Homo sapiens_hsa040140.22158941
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.21912471
124Phagosome_Homo sapiens_hsa041450.21794425
125Shigellosis_Homo sapiens_hsa051310.21735328
126Cardiac muscle contraction_Homo sapiens_hsa042600.21351743
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21179317
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21040592
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20937038
130N-Glycan biosynthesis_Homo sapiens_hsa005100.19618368
131Rheumatoid arthritis_Homo sapiens_hsa053230.19424164
132Legionellosis_Homo sapiens_hsa051340.19349616
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18992732
134GABAergic synapse_Homo sapiens_hsa047270.17465115
135Carbon metabolism_Homo sapiens_hsa012000.17272614
136Pentose phosphate pathway_Homo sapiens_hsa000300.14729820
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.13336746

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »