PTH2R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.83846641
2regulation of penile erection (GO:0060405)5.42825263
3regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.17959644
4neuron cell-cell adhesion (GO:0007158)4.94391258
5vocalization behavior (GO:0071625)4.91369468
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.84987906
7gamma-aminobutyric acid signaling pathway (GO:0007214)4.84196339
8regulation of glutamate receptor signaling pathway (GO:1900449)4.79628261
9regulation of synaptic vesicle exocytosis (GO:2000300)4.74829470
10cell wall macromolecule metabolic process (GO:0044036)4.73549629
11cell wall macromolecule catabolic process (GO:0016998)4.73549629
12presynaptic membrane assembly (GO:0097105)4.53198818
13response to pheromone (GO:0019236)4.53120710
14response to histamine (GO:0034776)4.38254415
15exploration behavior (GO:0035640)4.35044826
16piRNA metabolic process (GO:0034587)4.29201166
17synaptic vesicle exocytosis (GO:0016079)4.28735364
18postsynaptic membrane organization (GO:0001941)4.26939727
19positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.26749524
20protein localization to synapse (GO:0035418)4.19236535
21neuronal action potential propagation (GO:0019227)4.14498572
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.04496972
23regulation of short-term neuronal synaptic plasticity (GO:0048172)3.97084001
24cellular ketone body metabolic process (GO:0046950)3.91307464
25retinal cone cell development (GO:0046549)3.88357362
26negative regulation of amino acid transport (GO:0051956)3.85692656
27detection of light stimulus involved in sensory perception (GO:0050962)3.85069507
28detection of light stimulus involved in visual perception (GO:0050908)3.85069507
29DNA methylation involved in gamete generation (GO:0043046)3.83413163
30regulation of synaptic vesicle transport (GO:1902803)3.82095329
31neural tube formation (GO:0001841)3.80719879
32activation of protein kinase A activity (GO:0034199)3.78547745
33succinate metabolic process (GO:0006105)3.75429509
34neurotransmitter secretion (GO:0007269)3.74848406
35presynaptic membrane organization (GO:0097090)3.74002118
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73198798
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73100190
38proline transport (GO:0015824)3.72933894
39regulation of glutamate secretion (GO:0014048)3.70264333
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69934389
41ketone body metabolic process (GO:1902224)3.65686910
42cochlea development (GO:0090102)3.62919951
43neuron-neuron synaptic transmission (GO:0007270)3.58368720
44cerebellar granule cell differentiation (GO:0021707)3.57897934
45neurotransmitter-gated ion channel clustering (GO:0072578)3.57875815
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.56642299
47DNA double-strand break processing (GO:0000729)3.55331749
48gamma-aminobutyric acid transport (GO:0015812)3.54739504
49glutamate secretion (GO:0014047)3.52800830
50sperm motility (GO:0030317)3.52254177
51calcium ion-dependent exocytosis (GO:0017156)3.49858655
52synaptic vesicle maturation (GO:0016188)3.46874379
53cerebellar Purkinje cell layer development (GO:0021680)3.46839685
54acrosome reaction (GO:0007340)3.45093333
55synapsis (GO:0007129)3.43800327
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43785007
57axoneme assembly (GO:0035082)3.41552436
58auditory receptor cell stereocilium organization (GO:0060088)3.41399750
59cellular response to ammonium ion (GO:0071242)3.40108002
60ionotropic glutamate receptor signaling pathway (GO:0035235)3.39771787
61epithelial cilium movement (GO:0003351)3.37216898
62establishment of protein localization to Golgi (GO:0072600)3.36193947
63protein localization to cilium (GO:0061512)3.35059980
64neuron recognition (GO:0008038)3.32967201
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.31308900
66cellular potassium ion homeostasis (GO:0030007)3.27789742
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26831453
68energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.26651664
69ATP hydrolysis coupled proton transport (GO:0015991)3.26651664
70glutamate receptor signaling pathway (GO:0007215)3.26500498
71prenylation (GO:0097354)3.25952907
72protein prenylation (GO:0018342)3.25952907
73photoreceptor cell maintenance (GO:0045494)3.25895851
74indolalkylamine metabolic process (GO:0006586)3.25452611
75negative regulation of cytosolic calcium ion concentration (GO:0051481)3.23138149
76negative regulation of amine transport (GO:0051953)3.22438094
77cilium or flagellum-dependent cell motility (GO:0001539)3.20133788
78male meiosis (GO:0007140)3.16783384
79long-term synaptic potentiation (GO:0060291)3.16440840
80spermatid nucleus differentiation (GO:0007289)3.16309137
81respiratory chain complex IV assembly (GO:0008535)3.14337615
82synaptic transmission, glutamatergic (GO:0035249)3.13979816
83neuromuscular process controlling posture (GO:0050884)3.13409641
84adult walking behavior (GO:0007628)3.11119467
85protein polyglutamylation (GO:0018095)3.09356943
86neurotransmitter transport (GO:0006836)3.06405100
87centriole replication (GO:0007099)3.05400972
88resolution of meiotic recombination intermediates (GO:0000712)3.01757973
89tachykinin receptor signaling pathway (GO:0007217)2.99185426
90synaptic vesicle docking involved in exocytosis (GO:0016081)2.97698773
91synapse assembly (GO:0007416)2.96362228
92male meiosis I (GO:0007141)2.96201848
93positive regulation of synapse assembly (GO:0051965)2.96097672
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95987735
95cilium movement (GO:0003341)2.95267979
96sexual reproduction (GO:0019953)2.94103033
97L-fucose catabolic process (GO:0042355)2.93898403
98fucose catabolic process (GO:0019317)2.93898403
99L-fucose metabolic process (GO:0042354)2.93898403
100protein targeting to Golgi (GO:0000042)2.93598245
101regulation of synaptic transmission, GABAergic (GO:0032228)2.93502442
102cilium morphogenesis (GO:0060271)2.93335444
103cardiac left ventricle morphogenesis (GO:0003214)2.91179140
104regulation of cilium movement (GO:0003352)2.89540493
105behavioral response to nicotine (GO:0035095)2.88104733
106phosphorelay signal transduction system (GO:0000160)2.87363451
107positive regulation of potassium ion transmembrane transport (GO:1901381)2.87221589
108regulation of synapse assembly (GO:0051963)2.86779108
109negative regulation of mast cell activation (GO:0033004)2.86678574
110axonal fasciculation (GO:0007413)2.85486256
111sperm capacitation (GO:0048240)2.85324206
112microtubule anchoring (GO:0034453)2.83819678
113RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82985193
114reflex (GO:0060004)2.82977666
115positive regulation of cardiac muscle hypertrophy (GO:0010613)2.82895777
116positive regulation of muscle hypertrophy (GO:0014742)2.82895777
117one-carbon compound transport (GO:0019755)2.82744861
118clathrin coat assembly (GO:0048268)2.81828612
119detection of calcium ion (GO:0005513)2.81533522
120regulation of neurotransmitter secretion (GO:0046928)2.81080234
121regulation of protein kinase A signaling (GO:0010738)2.81034960
122C4-dicarboxylate transport (GO:0015740)2.80231231
123long-term memory (GO:0007616)2.80093491
124tryptophan catabolic process (GO:0006569)2.79622949
125indole-containing compound catabolic process (GO:0042436)2.79622949
126indolalkylamine catabolic process (GO:0046218)2.79622949
127reciprocal DNA recombination (GO:0035825)2.79496006
128reciprocal meiotic recombination (GO:0007131)2.79496006
129Rac protein signal transduction (GO:0016601)2.79229990
130inner ear receptor stereocilium organization (GO:0060122)2.79175480
131dicarboxylic acid catabolic process (GO:0043649)2.79139898
132regulation of neurotransmitter levels (GO:0001505)2.78637096
133DNA integration (GO:0015074)2.78417293
134synapse organization (GO:0050808)2.77823452
135regulation of female receptivity (GO:0045924)2.76938806
136regulation of synapse structural plasticity (GO:0051823)2.76723286
137righting reflex (GO:0060013)2.75789178
138negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.75744807
139left/right axis specification (GO:0070986)2.75381522
140fusion of sperm to egg plasma membrane (GO:0007342)2.74782212
141positive regulation of membrane potential (GO:0045838)2.74123923
142regulation of dendritic spine morphogenesis (GO:0061001)2.73697645
143multicellular organism reproduction (GO:0032504)2.73120119
144neurotransmitter biosynthetic process (GO:0042136)2.72840304
145intraciliary transport (GO:0042073)2.72562991
146cilium organization (GO:0044782)2.72410378
147negative regulation of neurotransmitter secretion (GO:0046929)2.71576839
148membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70569834
149retrograde transport, vesicle recycling within Golgi (GO:0000301)2.69854937
150histone H2A acetylation (GO:0043968)2.68943418
151behavioral response to ethanol (GO:0048149)2.68883585
152regulation of excitatory postsynaptic membrane potential (GO:0060079)2.68541337
153cilium assembly (GO:0042384)2.68105759
154negative regulation of inclusion body assembly (GO:0090084)2.67942316
155dendritic spine morphogenesis (GO:0060997)2.67920093
156negative regulation of catecholamine secretion (GO:0033604)2.67700144
157synaptic transmission (GO:0007268)2.67278585
158regulation of vesicle fusion (GO:0031338)2.67065900
159nonmotile primary cilium assembly (GO:0035058)2.66604652
160S-adenosylmethionine metabolic process (GO:0046500)2.66439893
161photoreceptor cell development (GO:0042461)2.65176854
162platelet dense granule organization (GO:0060155)2.60524098
163indole-containing compound metabolic process (GO:0042430)2.59927589
164protein K11-linked deubiquitination (GO:0035871)2.59369345
165G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57811386
166tryptophan metabolic process (GO:0006568)2.57345334
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56978773
168regulation of collateral sprouting (GO:0048670)2.56325695
169cytochrome complex assembly (GO:0017004)2.55750402
170eye photoreceptor cell development (GO:0042462)2.55456214
171L-methionine biosynthetic process (GO:0071265)2.53860405
172amino acid salvage (GO:0043102)2.53860405
173L-methionine salvage (GO:0071267)2.53860405
174double-strand break repair via homologous recombination (GO:0000724)2.52764680
175recombinational repair (GO:0000725)2.52127428
176nerve growth factor signaling pathway (GO:0038180)2.50542831
177regulation of female gonad development (GO:2000194)2.49829245
178NAD biosynthetic process (GO:0009435)2.48888489
179DNA deamination (GO:0045006)2.47009102
180positive regulation of growth hormone secretion (GO:0060124)2.43683193
181regulation of memory T cell differentiation (GO:0043380)2.43396114
182somite rostral/caudal axis specification (GO:0032525)2.43141296
183branched-chain amino acid catabolic process (GO:0009083)2.42630713
184methionine biosynthetic process (GO:0009086)2.41392902
185glycosphingolipid biosynthetic process (GO:0006688)2.39809059
186kynurenine metabolic process (GO:0070189)2.39424559
187adaptation of signaling pathway (GO:0023058)2.39329744
188positive regulation of oligodendrocyte differentiation (GO:0048714)2.37555339
189membrane depolarization during action potential (GO:0086010)2.34954973
190gene silencing by RNA (GO:0031047)2.34859520
191signal peptide processing (GO:0006465)2.34768425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75263240
2VDR_22108803_ChIP-Seq_LS180_Human3.35038241
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.31902709
4TAF15_26573619_Chip-Seq_HEK293_Human3.20466102
5GBX2_23144817_ChIP-Seq_PC3_Human3.18151281
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78205506
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76056357
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47820060
9REST_21632747_ChIP-Seq_MESCs_Mouse2.41396530
10EWS_26573619_Chip-Seq_HEK293_Human2.39635470
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35888397
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28940198
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26000120
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25798010
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.22668120
16* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22067802
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.20514837
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19406970
19* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18324753
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.18204324
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16410418
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16410418
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13184149
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08897162
25FUS_26573619_Chip-Seq_HEK293_Human2.06135857
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04171331
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92381647
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.88626462
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.87206705
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.86857089
31SMAD4_21799915_ChIP-Seq_A2780_Human1.84099341
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82910685
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80710184
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79336991
35* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72924207
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.72790349
37* P300_19829295_ChIP-Seq_ESCs_Human1.71828056
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67190164
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.65401536
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63212930
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63187895
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62923898
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61278496
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.56405158
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54077040
46MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52687213
47IRF1_19129219_ChIP-ChIP_H3396_Human1.51939490
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49126073
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46262638
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45456262
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44189565
52TP53_22573176_ChIP-Seq_HFKS_Human1.43611211
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43531254
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43306308
55* FLI1_27457419_Chip-Seq_LIVER_Mouse1.42565748
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41276480
57DROSHA_22980978_ChIP-Seq_HELA_Human1.39792978
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39665968
59RNF2_27304074_Chip-Seq_NSC_Mouse1.38395679
60AR_21572438_ChIP-Seq_LNCaP_Human1.38122393
61SOX2_19829295_ChIP-Seq_ESCs_Human1.35831922
62NANOG_19829295_ChIP-Seq_ESCs_Human1.35831922
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35557603
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.35154139
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34576676
66* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33534719
67* EZH2_27294783_Chip-Seq_NPCs_Mouse1.33155552
68* KDM2B_26808549_Chip-Seq_REH_Human1.32744477
69BCAT_22108803_ChIP-Seq_LS180_Human1.31731864
70* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31001651
71IGF1R_20145208_ChIP-Seq_DFB_Human1.30574350
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30536065
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30219357
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27889260
75TCF4_22108803_ChIP-Seq_LS180_Human1.27630824
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27155734
77* NANOG_18555785_Chip-Seq_ESCs_Mouse1.26487203
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26374546
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25246925
80AR_25329375_ChIP-Seq_VCAP_Human1.24405099
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23670367
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21228921
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20397240
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.20177911
85ELK1_19687146_ChIP-ChIP_HELA_Human1.18858734
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.18073682
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17776616
88CBP_20019798_ChIP-Seq_JUKART_Human1.17776616
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16792305
90* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16424775
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.16377334
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16030524
93TCF4_23295773_ChIP-Seq_U87_Human1.15500773
94* CMYC_18555785_Chip-Seq_ESCs_Mouse1.15407792
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.15223613
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14761044
97* CRX_20693478_ChIP-Seq_RETINA_Mouse1.14553310
98ER_23166858_ChIP-Seq_MCF-7_Human1.14389401
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.14103006
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14103006
101* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14082501
102* TAL1_26923725_Chip-Seq_HPCs_Mouse1.13633581
103* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13314071
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.12683887
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12042123
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11665266
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11370013
108* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11084392
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10700449
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10446673
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10446673
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10377118
113* NFE2_27457419_Chip-Seq_LIVER_Mouse1.09981634
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09840052
115STAT3_23295773_ChIP-Seq_U87_Human1.08400968
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08004358
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07966421
118* P53_22387025_ChIP-Seq_ESCs_Mouse1.07280470
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06446275
120JUN_21703547_ChIP-Seq_K562_Human1.05961858
121GATA1_26923725_Chip-Seq_HPCs_Mouse1.05875360
122ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05585800
123* CDX2_22108803_ChIP-Seq_LS180_Human1.05163210
124VDR_23849224_ChIP-Seq_CD4+_Human1.04839117
125AR_20517297_ChIP-Seq_VCAP_Human1.04785439
126TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03848335
127SOX9_26525672_Chip-Seq_HEART_Mouse1.03124430
128RING1B_27294783_Chip-Seq_ESCs_Mouse1.02326246
129* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02047268
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.01920355
131ZNF274_21170338_ChIP-Seq_K562_Hela1.01824801
132SMAD3_21741376_ChIP-Seq_ESCs_Human1.01364757
133EP300_21415370_ChIP-Seq_HL-1_Mouse1.01277417
134* STAT3_18555785_Chip-Seq_ESCs_Mouse1.00929040
135EST1_17652178_ChIP-ChIP_JURKAT_Human1.00718786
136NCOR_22424771_ChIP-Seq_293T_Human1.00560062
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.00507519
138KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00452661
139SMAD_19615063_ChIP-ChIP_OVARY_Human0.99769671
140* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98402077
141PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97570754
142* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97125184
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95184373
144* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95069148
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95056909

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.52921431
2MP0003880_abnormal_central_pattern3.92353365
3MP0003635_abnormal_synaptic_transmissio3.67799909
4MP0009046_muscle_twitch3.59899253
5MP0000372_irregular_coat_pigmentation3.36870904
6MP0009745_abnormal_behavioral_response3.21067164
7MP0002064_seizures3.06616990
8MP0002822_catalepsy2.87987597
9MP0002102_abnormal_ear_morphology2.83574731
10MP0002063_abnormal_learning/memory/cond2.80589724
11MP0001968_abnormal_touch/_nociception2.72237560
12MP0002272_abnormal_nervous_system2.61745599
13MP0009780_abnormal_chondrocyte_physiolo2.53500089
14MP0005410_abnormal_fertilization2.53252614
15MP0002572_abnormal_emotion/affect_behav2.41531032
16MP0002837_dystrophic_cardiac_calcinosis2.41325018
17MP0002735_abnormal_chemical_nociception2.39683347
18MP0004270_analgesia2.39437191
19MP0003329_amyloid_beta_deposits2.35319106
20MP0005423_abnormal_somatic_nervous2.24243052
21MP0003195_calcinosis2.23538731
22MP0008057_abnormal_DNA_replication2.15376184
23MP0000569_abnormal_digit_pigmentation2.15025051
24MP0002734_abnormal_mechanical_nocicepti2.13635533
25MP0003122_maternal_imprinting2.12825749
26MP0001501_abnormal_sleep_pattern2.03682114
27MP0002736_abnormal_nociception_after1.96653574
28MP0001486_abnormal_startle_reflex1.96302717
29MP0000013_abnormal_adipose_tissue1.92841458
30MP0002067_abnormal_sensory_capabilities1.90636984
31MP0008260_abnormal_autophagy1.89841233
32MP0002733_abnormal_thermal_nociception1.81216474
33MP0002876_abnormal_thyroid_physiology1.80334487
34MP0005646_abnormal_pituitary_gland1.80324177
35MP0006072_abnormal_retinal_apoptosis1.78350533
36MP0003136_yellow_coat_color1.72411602
37MP0005174_abnormal_tail_pigmentation1.70073195
38MP0003183_abnormal_peptide_metabolism1.69376007
39MP0002184_abnormal_innervation1.68913529
40MP0001188_hyperpigmentation1.68567704
41MP0005253_abnormal_eye_physiology1.67575182
42MP0001440_abnormal_grooming_behavior1.66607934
43MP0001970_abnormal_pain_threshold1.64343457
44MP0001485_abnormal_pinna_reflex1.64101847
45MP0005623_abnormal_meninges_morphology1.62896593
46MP0000778_abnormal_nervous_system1.59221722
47MP0003787_abnormal_imprinting1.58847524
48MP0005386_behavior/neurological_phenoty1.57350511
49MP0004924_abnormal_behavior1.57350511
50MP0003718_maternal_effect1.54394016
51MP0001986_abnormal_taste_sensitivity1.54177962
52MP0006276_abnormal_autonomic_nervous1.51652161
53MP0004043_abnormal_pH_regulation1.51611592
54MP0009697_abnormal_copulation1.49947565
55MP0008058_abnormal_DNA_repair1.49125489
56MP0003656_abnormal_erythrocyte_physiolo1.48298032
57MP0001529_abnormal_vocalization1.46877582
58MP0002638_abnormal_pupillary_reflex1.46089873
59MP0003879_abnormal_hair_cell1.44409336
60MP0002095_abnormal_skin_pigmentation1.42172786
61MP0004811_abnormal_neuron_physiology1.39472626
62MP0000751_myopathy1.38947461
63MP0004142_abnormal_muscle_tone1.38334661
64MP0008569_lethality_at_weaning1.37786819
65MP0000015_abnormal_ear_pigmentation1.36443798
66MP0002557_abnormal_social/conspecific_i1.34812513
67MP0000604_amyloidosis1.32332518
68MP0004233_abnormal_muscle_weight1.28709447
69MP0008995_early_reproductive_senescence1.28664587
70MP0002066_abnormal_motor_capabilities/c1.27953287
71MP0002909_abnormal_adrenal_gland1.25799640
72MP0002882_abnormal_neuron_morphology1.23994303
73MP0008789_abnormal_olfactory_epithelium1.23974982
74MP0000427_abnormal_hair_cycle1.23435593
75MP0001545_abnormal_hematopoietic_system1.22469413
76MP0005397_hematopoietic_system_phenotyp1.22469413
77MP0000955_abnormal_spinal_cord1.21807606
78MP0001764_abnormal_homeostasis1.20582915
79MP0002928_abnormal_bile_duct1.20206288
80MP0003123_paternal_imprinting1.19176235
81MP0004147_increased_porphyrin_level1.17713330
82MP0002938_white_spotting1.16901518
83MP0006292_abnormal_olfactory_placode1.15884077
84MP0001929_abnormal_gametogenesis1.13019423
85MP0005551_abnormal_eye_electrophysiolog1.12290238
86MP0005645_abnormal_hypothalamus_physiol1.11672362
87MP0001177_atelectasis1.11669382
88MP0003121_genomic_imprinting1.10043225
89MP0005647_abnormal_sex_gland1.09137779
90MP0010386_abnormal_urinary_bladder1.07578911
91MP0000631_abnormal_neuroendocrine_gland1.06030610
92MP0005394_taste/olfaction_phenotype1.05081795
93MP0005499_abnormal_olfactory_system1.05081795
94MP0001502_abnormal_circadian_rhythm1.03616440
95MP0000383_abnormal_hair_follicle1.01966858
96MP0003633_abnormal_nervous_system1.01709263
97MP0005075_abnormal_melanosome_morpholog1.00432369
98MP0003631_nervous_system_phenotype1.00254196
99MP0002090_abnormal_vision0.99342008
100MP0005084_abnormal_gallbladder_morpholo0.99068186
101MP0008875_abnormal_xenobiotic_pharmacok0.98030221
102MP0004019_abnormal_vitamin_homeostasis0.97872816
103MP0004085_abnormal_heartbeat0.97502748
104MP0001984_abnormal_olfaction0.97337373
105MP0008877_abnormal_DNA_methylation0.96525535
106MP0002132_abnormal_respiratory_system0.96141729
107MP0008872_abnormal_physiological_respon0.95122255
108MP0002152_abnormal_brain_morphology0.94022387
109MP0001270_distended_abdomen0.92873909
110MP0008874_decreased_physiological_sensi0.92542192
111MP0003252_abnormal_bile_duct0.90154866
112MP0002160_abnormal_reproductive_system0.90039087
113MP0004885_abnormal_endolymph0.89198414
114MP0003567_abnormal_fetal_cardiomyocyte0.88724476
115MP0001765_abnormal_ion_homeostasis0.87064681
116MP0002210_abnormal_sex_determination0.86847568
117MP0003632_abnormal_nervous_system0.86590077
118MP0004145_abnormal_muscle_electrophysio0.85640597
119MP0000653_abnormal_sex_gland0.85298046
120MP0003698_abnormal_male_reproductive0.84906669
121MP0005636_abnormal_mineral_homeostasis0.84559058
122MP0005377_hearing/vestibular/ear_phenot0.84430332
123MP0003878_abnormal_ear_physiology0.84430332
124MP0001963_abnormal_hearing_physiology0.82256634
125MP0003690_abnormal_glial_cell0.82020184
126MP0005379_endocrine/exocrine_gland_phen0.80474114
127MP0001299_abnormal_eye_distance/0.80383218
128MP0002229_neurodegeneration0.78914899
129MP0005535_abnormal_body_temperature0.78787997
130MP0004858_abnormal_nervous_system0.78511123
131MP0005220_abnormal_exocrine_pancreas0.77823422
132MP0002069_abnormal_eating/drinking_beha0.77688124
133MP0006036_abnormal_mitochondrial_physio0.77619442
134MP0005171_absent_coat_pigmentation0.76882515
135MP0003646_muscle_fatigue0.75625406
136MP0000920_abnormal_myelination0.75165919
137MP0001943_abnormal_respiration0.74904744
138MP0003634_abnormal_glial_cell0.74797876
139MP0004215_abnormal_myocardial_fiber0.72678557
140MP0002752_abnormal_somatic_nervous0.71888372
141MP0001905_abnormal_dopamine_level0.71163374
142MP0004742_abnormal_vestibular_system0.69486028
143MP0002254_reproductive_system_inflammat0.69390409
144MP0003638_abnormal_response/metabolism_0.64426322
145MP0000678_abnormal_parathyroid_gland0.64383487
146MP0002163_abnormal_gland_morphology0.61789323
147MP0004134_abnormal_chest_morphology0.61268260
148MP0003938_abnormal_ear_development0.60872177

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.88414168
2Atonic seizures (HP:0010819)6.05465213
3Absence seizures (HP:0002121)5.53830410
4Focal seizures (HP:0007359)5.36186872
5Epileptic encephalopathy (HP:0200134)5.32555987
6Febrile seizures (HP:0002373)5.12001467
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.09462845
8Absent/shortened dynein arms (HP:0200106)5.09462845
9Visual hallucinations (HP:0002367)4.75501886
10Dialeptic seizures (HP:0011146)4.49002678
11Generalized tonic-clonic seizures (HP:0002069)4.48913116
12Myokymia (HP:0002411)4.07998817
13Pancreatic cysts (HP:0001737)3.83932843
14Abnormal respiratory epithelium morphology (HP:0012253)3.75889431
15Abnormal respiratory motile cilium morphology (HP:0005938)3.75889431
16Pancreatic fibrosis (HP:0100732)3.65712951
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.54752733
18Impaired vibration sensation in the lower limbs (HP:0002166)3.45156711
19True hermaphroditism (HP:0010459)3.42836395
20Abnormal ciliary motility (HP:0012262)3.26789401
21Abnormal respiratory motile cilium physiology (HP:0012261)3.15998769
22Attenuation of retinal blood vessels (HP:0007843)3.08078145
23Medial flaring of the eyebrow (HP:0010747)3.07235230
24Progressive inability to walk (HP:0002505)3.06259668
25Abolished electroretinogram (ERG) (HP:0000550)3.06172822
26Nephronophthisis (HP:0000090)3.02707764
27Molar tooth sign on MRI (HP:0002419)2.94636326
28Abnormality of midbrain morphology (HP:0002418)2.94636326
29Hyperventilation (HP:0002883)2.93962972
30Polyphagia (HP:0002591)2.90730955
31Gaze-evoked nystagmus (HP:0000640)2.90203667
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.85398150
33Congenital stationary night blindness (HP:0007642)2.82414248
34Urinary urgency (HP:0000012)2.79836546
35Abnormality of the renal medulla (HP:0100957)2.79003089
36Poor eye contact (HP:0000817)2.73638690
37Infertility (HP:0000789)2.67129514
38Cystic liver disease (HP:0006706)2.65689537
39Congenital primary aphakia (HP:0007707)2.61953627
40Termporal pattern (HP:0011008)2.61661269
41Insidious onset (HP:0003587)2.61661269
42Hyperglycinemia (HP:0002154)2.58401858
43Abnormality of the renal cortex (HP:0011035)2.57735243
44Progressive cerebellar ataxia (HP:0002073)2.56377231
45Inability to walk (HP:0002540)2.53588473
46Abnormal rod and cone electroretinograms (HP:0008323)2.52866444
47Drooling (HP:0002307)2.52811631
48Excessive salivation (HP:0003781)2.52811631
49Abnormal eating behavior (HP:0100738)2.51903496
50Hyperthyroidism (HP:0000836)2.51286301
51Nephrogenic diabetes insipidus (HP:0009806)2.50353466
52Truncal ataxia (HP:0002078)2.47825240
53Sensory axonal neuropathy (HP:0003390)2.47252864
54Tubulointerstitial nephritis (HP:0001970)2.47134896
55Spastic diplegia (HP:0001264)2.45037943
56Impaired social interactions (HP:0000735)2.44990058
57Abnormal social behavior (HP:0012433)2.44990058
58Abnormality of binocular vision (HP:0011514)2.43262812
59Diplopia (HP:0000651)2.43262812
60Abnormality of the corticospinal tract (HP:0002492)2.42580478
61Chronic hepatic failure (HP:0100626)2.42181061
62Genetic anticipation (HP:0003743)2.40697036
63Anxiety (HP:0000739)2.38096131
64Ankle clonus (HP:0011448)2.37055386
65Intestinal atresia (HP:0011100)2.36802913
66Spastic gait (HP:0002064)2.36428529
67Rhinitis (HP:0012384)2.36125143
68Amblyopia (HP:0000646)2.34931458
69Hypomagnesemia (HP:0002917)2.33679912
70Broad-based gait (HP:0002136)2.33664435
71Hyperglycinuria (HP:0003108)2.30243568
72Hypothermia (HP:0002045)2.29716948
73Urinary bladder sphincter dysfunction (HP:0002839)2.29342524
74Epileptiform EEG discharges (HP:0011182)2.28049993
75Scanning speech (HP:0002168)2.25765577
76Supranuclear gaze palsy (HP:0000605)2.24927812
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.24219401
78Dysmetria (HP:0001310)2.24211224
79Genital tract atresia (HP:0001827)2.23665003
80Methylmalonic acidemia (HP:0002912)2.22912801
81Dysdiadochokinesis (HP:0002075)2.21019993
82Neurofibrillary tangles (HP:0002185)2.20823470
83Psychosis (HP:0000709)2.20433881
84Absent speech (HP:0001344)2.17943044
85Dysmetric saccades (HP:0000641)2.17809118
86EEG with generalized epileptiform discharges (HP:0011198)2.17000791
87Sleep apnea (HP:0010535)2.16574303
88Thyroiditis (HP:0100646)2.16486638
89Cerebral inclusion bodies (HP:0100314)2.14961345
90Type II lissencephaly (HP:0007260)2.14187929
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14023672
92Degeneration of the lateral corticospinal tracts (HP:0002314)2.14023672
93Torticollis (HP:0000473)2.13957942
94Impaired smooth pursuit (HP:0007772)2.12776635
95Abnormality of B cell number (HP:0010975)2.12207391
96Ankyloglossia (HP:0010296)2.11882103
97Abnormality of glycine metabolism (HP:0010895)2.11317634
98Abnormality of serine family amino acid metabolism (HP:0010894)2.11317634
99Aplasia/Hypoplasia of the tongue (HP:0010295)2.10682150
100Bony spicule pigmentary retinopathy (HP:0007737)2.10441642
101Bile duct proliferation (HP:0001408)2.10357784
102Abnormal biliary tract physiology (HP:0012439)2.10357784
103Agitation (HP:0000713)2.09970152
104Methylmalonic aciduria (HP:0012120)2.09943863
105Aplasia/Hypoplasia of the tibia (HP:0005772)2.09925328
106Depression (HP:0000716)2.08866469
107Vaginal atresia (HP:0000148)2.07145565
108Cerebellar dysplasia (HP:0007033)2.04923910
109Renal cortical cysts (HP:0000803)2.03302742
110Failure to thrive in infancy (HP:0001531)2.02861388
111Abnormality of oral frenula (HP:0000190)2.02044685
112Abnormal drinking behavior (HP:0030082)2.01658991
113Polydipsia (HP:0001959)2.01658991
114Retinal dysplasia (HP:0007973)2.01030638
115Tubular atrophy (HP:0000092)2.00661425
116Oligomenorrhea (HP:0000876)2.00342869
117Resting tremor (HP:0002322)1.99384150
118Abnormality of the labia minora (HP:0012880)1.98358183
119Poor suck (HP:0002033)1.97942562
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97523757
121Abnormality of alanine metabolism (HP:0010916)1.97523757
122Hyperalaninemia (HP:0003348)1.97523757
123Status epilepticus (HP:0002133)1.97224539
124Menstrual irregularities (HP:0000858)1.96280802
125Increased circulating renin level (HP:0000848)1.96235681
126Impaired vibratory sensation (HP:0002495)1.95157353
127Focal dystonia (HP:0004373)1.92469453
128Increased corneal curvature (HP:0100692)1.92009817
129Keratoconus (HP:0000563)1.92009817
130B lymphocytopenia (HP:0010976)1.91264449
131Hypoproteinemia (HP:0003075)1.90115611
132Furrowed tongue (HP:0000221)1.90100742
133Lower limb muscle weakness (HP:0007340)1.89143648
134Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88761711
135Polyuria (HP:0000103)1.88490497
136Postaxial foot polydactyly (HP:0001830)1.88219368
137Abnormal gallbladder physiology (HP:0012438)1.88151794
138Cholecystitis (HP:0001082)1.88151794
139Neoplasm of the adrenal cortex (HP:0100641)1.88150700
140Oligodontia (HP:0000677)1.88083743
141Split foot (HP:0001839)1.87580711
142Central scotoma (HP:0000603)1.87567615
143Poor coordination (HP:0002370)1.86991401
144Abnormality of ocular smooth pursuit (HP:0000617)1.86881530
145Hypsarrhythmia (HP:0002521)1.85988117
146Narrow nasal bridge (HP:0000446)1.85868703
147Widely spaced teeth (HP:0000687)1.84569534
148Generalized hypotonia (HP:0001290)1.84444750
149Hemiparesis (HP:0001269)1.83846989
150Abnormality of macular pigmentation (HP:0008002)1.83135283
151Decreased central vision (HP:0007663)1.82804277
152Gait imbalance (HP:0002141)1.82756978
153Lissencephaly (HP:0001339)1.82597622
154Craniofacial dystonia (HP:0012179)1.82449756
155Protruding tongue (HP:0010808)1.82210530
156Congenital hepatic fibrosis (HP:0002612)1.81607671
157Tubulointerstitial abnormality (HP:0001969)1.81362253
158Abnormality of serum amino acid levels (HP:0003112)1.79853252
159Limb dystonia (HP:0002451)1.78959447
160Clonus (HP:0002169)1.78527617
161Ketoacidosis (HP:0001993)1.78133260
162Severe combined immunodeficiency (HP:0004430)1.77673818
163Hypoplasia of the fovea (HP:0007750)1.77610735
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.77610735
165Increased CSF lactate (HP:0002490)1.77601693
166Poikilocytosis (HP:0004447)1.76210234
167Bradykinesia (HP:0002067)1.75083806
168Sclerocornea (HP:0000647)1.74461537
169Fetal akinesia sequence (HP:0001989)1.73573761
170Abnormality of salivation (HP:0100755)1.73428963
171Hypokalemic alkalosis (HP:0001949)1.73207890
172Optic nerve hypoplasia (HP:0000609)1.73166632
173Astigmatism (HP:0000483)1.72381087
174Open mouth (HP:0000194)1.67983038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.51721126
2PDK45.51721126
3FRK5.06150863
4NTRK33.85402656
5PDK23.46632002
6MAP3K123.38017190
7AKT33.27751158
8MAP3K93.23427914
9WNK33.10543319
10MAP4K22.90588886
11CASK2.88335642
12CCNB12.81040253
13TRIM282.40523984
14NUAK12.27176419
15MAP3K42.24759372
16MUSK2.22931430
17ACVR1B2.21423882
18EPHA42.20281200
19BMPR1B2.19315226
20MAP2K72.14432277
21MAP2K42.04970636
22ERBB31.96879702
23PLK21.89867448
24EIF2AK31.89618273
25PINK11.86971387
26MARK11.83368575
27MAP3K21.82425830
28NTRK21.80749474
29GRK11.72876663
30MYLK1.68767840
31ERBB41.66914645
32MINK11.64809411
33BCR1.63807887
34PLK41.60317624
35ZAK1.51212662
36KSR21.51027390
37GRK51.49787766
38LATS11.47701040
39DAPK21.47357007
40DAPK11.40860723
41BCKDK1.37382355
42PAK61.35027758
43BRAF1.34418131
44ARAF1.33943061
45SIK31.32463380
46CDK191.32100280
47KSR11.25289006
48INSRR1.24294050
49MKNK21.24016882
50UHMK11.21213551
51CSNK1A1L1.17373262
52PAK31.16641021
53STK38L1.15822104
54DYRK31.11787284
55CSNK1G31.06396265
56CSNK1G11.01461710
57MKNK11.01233607
58RAF11.00291267
59TAOK30.98741937
60TEC0.98532656
61CDK50.95992152
62RPS6KA40.94645144
63CAMK2A0.93154565
64PKN10.91316214
65RIPK40.90298627
66OXSR10.87641579
67PRKCE0.85259665
68PIK3CG0.82018357
69FER0.81670436
70FES0.81298529
71BRD40.80202909
72PNCK0.78956262
73NTRK10.78273743
74FLT30.77504108
75PRKCG0.77097023
76WNK40.75985791
77STK30.74389808
78IRAK10.73661085
79PDK10.72824234
80MAP3K60.71782869
81DYRK1A0.71758376
82RET0.70548469
83LIMK10.69059704
84CAMK2G0.68847592
85TNK20.68432593
86MARK20.66341588
87CAMK10.64567603
88SGK2230.63611461
89SGK4940.63611461
90SGK20.61796994
91TESK20.58811559
92TXK0.58398042
93CDK30.57661596
94CAMKK20.53337908
95DAPK30.53284106
96ICK0.51585584
97SGK10.51547172
98MAP3K70.50950648
99MATK0.50617236
100CDK140.49778394
101CDK180.49142769
102CDK150.48337853
103CAMK2B0.47861213
104EIF2AK10.47368717
105LMTK20.46812499
106RPS6KA50.46695690
107PHKG20.46279729
108PHKG10.46279729
109PASK0.45889456
110MAPKAPK50.45815992
111MAP3K10.45567801
112BRSK20.44456463
113TGFBR10.43484975
114PDPK10.43050335
115RPS6KB10.42838795
116GRK70.42130738
117TNIK0.41872841
118MAPK120.41662528
119EPHA30.41013947
120CDC42BPA0.41009485
121SIK20.40699416
122SYK0.40381010
123TRPM70.40149181
124STK160.37921505
125CAMK2D0.37466126
126CDK11A0.37204847
127PRKAA20.36837113
128PRKAA10.35985247
129CSNK1A10.35892981
130ATM0.35500238
131PTK2B0.35315928
132CSNK1G20.35074485
133PRKCQ0.34840158
134SGK30.34804172
135OBSCN0.34769777
136MAP2K10.33593709
137VRK10.32988549
138MST40.32727702
139CSNK1D0.32635647
140PLK30.32589727
141ROCK20.32545769
142ATR0.32482381
143* PRKCB0.32321345
144NME10.31914042
145MAPK130.30812354
146STK380.30350028
147* RPS6KA30.29181374
148TSSK60.28838379
149STK390.28090118
150PRKACA0.27931651
151MAP3K50.26430007
152LATS20.24836396
153BMPR20.24396362
154MAPK40.24271240
155SCYL20.24226609
156ADRBK20.23559885
157CAMKK10.23449936
158HIPK20.22907910
159PRKG10.22395351
160STK110.22259419
161ROCK10.22140636
162FYN0.21654577
163ADRBK10.20625689

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.96033993
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.24578209
3Phototransduction_Homo sapiens_hsa047443.18482107
4GABAergic synapse_Homo sapiens_hsa047273.15810026
5Synaptic vesicle cycle_Homo sapiens_hsa047212.97645364
6Propanoate metabolism_Homo sapiens_hsa006402.90033735
7Collecting duct acid secretion_Homo sapiens_hsa049662.76583950
8Morphine addiction_Homo sapiens_hsa050322.76114702
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74768682
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.67148013
11Basal transcription factors_Homo sapiens_hsa030222.34614171
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28848489
13Circadian entrainment_Homo sapiens_hsa047132.17172687
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16613132
15Non-homologous end-joining_Homo sapiens_hsa034502.14930454
16Glutamatergic synapse_Homo sapiens_hsa047242.12860990
17Homologous recombination_Homo sapiens_hsa034402.12460243
18Taste transduction_Homo sapiens_hsa047422.05512461
19Long-term potentiation_Homo sapiens_hsa047201.98377262
20Protein export_Homo sapiens_hsa030601.93111406
21Fanconi anemia pathway_Homo sapiens_hsa034601.92674265
22Long-term depression_Homo sapiens_hsa047301.80908823
23Salivary secretion_Homo sapiens_hsa049701.79765311
24Dopaminergic synapse_Homo sapiens_hsa047281.78865717
25Amphetamine addiction_Homo sapiens_hsa050311.74163087
26Serotonergic synapse_Homo sapiens_hsa047261.73289720
27Tryptophan metabolism_Homo sapiens_hsa003801.71578449
28Renin secretion_Homo sapiens_hsa049241.70634741
29Olfactory transduction_Homo sapiens_hsa047401.70251274
30Linoleic acid metabolism_Homo sapiens_hsa005911.67440538
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65744246
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57211363
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55922537
34Regulation of autophagy_Homo sapiens_hsa041401.55332046
35Insulin secretion_Homo sapiens_hsa049111.53792376
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52595177
37Vibrio cholerae infection_Homo sapiens_hsa051101.52588393
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52120847
39Gastric acid secretion_Homo sapiens_hsa049711.51452594
40Butanoate metabolism_Homo sapiens_hsa006501.50217594
41Type I diabetes mellitus_Homo sapiens_hsa049401.47744852
42RNA degradation_Homo sapiens_hsa030181.44228313
43Cholinergic synapse_Homo sapiens_hsa047251.43052964
44* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40695052
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.38510921
46Caffeine metabolism_Homo sapiens_hsa002321.36153768
47ABC transporters_Homo sapiens_hsa020101.31645934
48Peroxisome_Homo sapiens_hsa041461.30841080
49Oxytocin signaling pathway_Homo sapiens_hsa049211.30197313
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28640767
51Cardiac muscle contraction_Homo sapiens_hsa042601.25324287
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24935463
53Calcium signaling pathway_Homo sapiens_hsa040201.24532957
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22823080
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22045008
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16497171
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16204624
58Oxidative phosphorylation_Homo sapiens_hsa001901.16159976
59Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13711325
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11439341
61cAMP signaling pathway_Homo sapiens_hsa040241.09729651
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09166228
63Circadian rhythm_Homo sapiens_hsa047101.08915950
64Vascular smooth muscle contraction_Homo sapiens_hsa042701.07257731
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06551812
66Cocaine addiction_Homo sapiens_hsa050301.06071845
67Estrogen signaling pathway_Homo sapiens_hsa049151.04656169
68Steroid hormone biosynthesis_Homo sapiens_hsa001401.03406268
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01391828
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98237509
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97920552
72Gap junction_Homo sapiens_hsa045400.97591633
73Axon guidance_Homo sapiens_hsa043600.97541896
74Bile secretion_Homo sapiens_hsa049760.96009086
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95104588
76Dilated cardiomyopathy_Homo sapiens_hsa054140.94979756
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94483653
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92583618
79Ovarian steroidogenesis_Homo sapiens_hsa049130.90563259
80Retinol metabolism_Homo sapiens_hsa008300.90305703
81GnRH signaling pathway_Homo sapiens_hsa049120.85267528
82Chemical carcinogenesis_Homo sapiens_hsa052040.81822198
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80653191
84Thyroid hormone synthesis_Homo sapiens_hsa049180.79966957
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79323458
86Pyruvate metabolism_Homo sapiens_hsa006200.78561600
87Fatty acid metabolism_Homo sapiens_hsa012120.77779062
88Rheumatoid arthritis_Homo sapiens_hsa053230.77435039
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.75504465
90Fatty acid elongation_Homo sapiens_hsa000620.75375669
91RNA polymerase_Homo sapiens_hsa030200.75101767
92RNA transport_Homo sapiens_hsa030130.72988218
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72181866
94Alzheimers disease_Homo sapiens_hsa050100.71354975
95Type II diabetes mellitus_Homo sapiens_hsa049300.70272306
96Fatty acid biosynthesis_Homo sapiens_hsa000610.69985465
97Glioma_Homo sapiens_hsa052140.68936312
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68909689
99Arachidonic acid metabolism_Homo sapiens_hsa005900.67590949
100Purine metabolism_Homo sapiens_hsa002300.64225188
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64145278
102Fatty acid degradation_Homo sapiens_hsa000710.63901263
103Glucagon signaling pathway_Homo sapiens_hsa049220.63759746
104Oocyte meiosis_Homo sapiens_hsa041140.61314110
105beta-Alanine metabolism_Homo sapiens_hsa004100.61224878
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60517442
107Selenocompound metabolism_Homo sapiens_hsa004500.59128422
108Prion diseases_Homo sapiens_hsa050200.58865646
109Pancreatic secretion_Homo sapiens_hsa049720.58256344
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57856065
111Metabolic pathways_Homo sapiens_hsa011000.57399134
112One carbon pool by folate_Homo sapiens_hsa006700.56751465
113Melanogenesis_Homo sapiens_hsa049160.56737002
114Lysine degradation_Homo sapiens_hsa003100.55910598
115Parkinsons disease_Homo sapiens_hsa050120.55846149
116Phagosome_Homo sapiens_hsa041450.55626300
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55612434
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53380466
119Ether lipid metabolism_Homo sapiens_hsa005650.52594220
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52455502
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49940741
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48190661
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47164035
124MAPK signaling pathway_Homo sapiens_hsa040100.47163130
125ErbB signaling pathway_Homo sapiens_hsa040120.45390293
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44798398
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44775071
128Dorso-ventral axis formation_Homo sapiens_hsa043200.43836664
129Huntingtons disease_Homo sapiens_hsa050160.43444417
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43093250
131Asthma_Homo sapiens_hsa053100.42555809
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.42207530
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40375759
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39026055
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38948844
136Steroid biosynthesis_Homo sapiens_hsa001000.38670663
137Nucleotide excision repair_Homo sapiens_hsa034200.38239595
138Nitrogen metabolism_Homo sapiens_hsa009100.38130160
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37349075
140Arginine biosynthesis_Homo sapiens_hsa002200.36893334
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34651453
142Glycerolipid metabolism_Homo sapiens_hsa005610.34402215
143Ras signaling pathway_Homo sapiens_hsa040140.33925334
144VEGF signaling pathway_Homo sapiens_hsa043700.32919847
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32664831
146Base excision repair_Homo sapiens_hsa034100.32341968
147Melanoma_Homo sapiens_hsa052180.31587722
148Rap1 signaling pathway_Homo sapiens_hsa040150.31436063
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30774043
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.30634231
151Renal cell carcinoma_Homo sapiens_hsa052110.27714958
152Inositol phosphate metabolism_Homo sapiens_hsa005620.27276676
153Alcoholism_Homo sapiens_hsa050340.26766860
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26403644

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