PTHLH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-substrate junction assembly (GO:0007044)8.99346473
2regulation of penile erection (GO:0060405)7.58825609
3uronic acid metabolic process (GO:0006063)6.91737552
4glucuronate metabolic process (GO:0019585)6.91737552
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.86513394
6cellular glucuronidation (GO:0052695)6.69032713
7establishment of skin barrier (GO:0061436)6.60601956
8regulation of keratinocyte proliferation (GO:0010837)6.46505812
9desmosome organization (GO:0002934)6.26384471
10regulation of water loss via skin (GO:0033561)6.24676594
11prostate gland growth (GO:0060736)6.18698094
12cell adhesion mediated by integrin (GO:0033627)5.95414805
13regulation of hair follicle development (GO:0051797)5.84831258
14intermediate filament organization (GO:0045109)5.64142730
15dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.62134359
16positive regulation of epidermis development (GO:0045684)5.16960949
17keratinocyte development (GO:0003334)5.16089960
18gap junction assembly (GO:0016264)5.11574645
19regulation of transforming growth factor beta2 production (GO:0032909)5.06785650
20positive regulation of epidermal cell differentiation (GO:0045606)5.04091778
21positive regulation of hair follicle development (GO:0051798)5.00023700
22positive regulation of hair cycle (GO:0042635)5.00023700
23succinate metabolic process (GO:0006105)4.82975264
24mesodermal cell differentiation (GO:0048333)4.70254226
25endodermal cell differentiation (GO:0035987)4.63078510
26molting cycle (GO:0042303)4.54724083
27hair cycle (GO:0042633)4.54724083
28negative regulation of keratinocyte proliferation (GO:0010839)4.50762270
29* epidermis development (GO:0008544)4.49161302
30regulation of chemokine secretion (GO:0090196)4.42078522
31regulation of glomerular filtration (GO:0003093)4.41865976
32hemidesmosome assembly (GO:0031581)4.36945239
33lung lobe morphogenesis (GO:0060463)4.33650339
34positive regulation of interleukin-8 secretion (GO:2000484)4.29928655
35skin morphogenesis (GO:0043589)4.24535740
36hypotonic response (GO:0006971)4.07827897
37keratinization (GO:0031424)4.07270005
38positive regulation of cellular amide metabolic process (GO:0034250)4.06833673
39polarized epithelial cell differentiation (GO:0030859)4.04095652
40prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.04049660
41regulation of hair cycle (GO:0042634)4.03966565
42establishment of tissue polarity (GO:0007164)4.02592886
43establishment of planar polarity (GO:0001736)4.02592886
44protein localization to endosome (GO:0036010)4.02188923
45negative regulation of dendrite morphogenesis (GO:0050774)3.88444117
46positive regulation of actin filament depolymerization (GO:0030836)3.86983718
47multicellular organismal water homeostasis (GO:0050891)3.86357221
48keratinocyte differentiation (GO:0030216)3.83653895
49epithelial cell differentiation involved in prostate gland development (GO:0060742)3.82985387
50regulation of epidermis development (GO:0045682)3.78638456
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76262329
52ectoderm development (GO:0007398)3.76209154
53regulation of heart rate by cardiac conduction (GO:0086091)3.75485896
54cell junction assembly (GO:0034329)3.73496053
55transferrin transport (GO:0033572)3.67931762
56lateral sprouting from an epithelium (GO:0060601)3.66136014
57ferric iron transport (GO:0015682)3.64639475
58trivalent inorganic cation transport (GO:0072512)3.64639475
59regulation of transforming growth factor beta1 production (GO:0032908)3.64354041
60negative regulation of epidermis development (GO:0045683)3.53553484
61neurotransmitter biosynthetic process (GO:0042136)3.51896446
62positive regulation of heat generation (GO:0031652)3.50850510
63renal system process involved in regulation of blood volume (GO:0001977)3.50802756
64mammary gland development (GO:0030879)3.49377952
65cell junction organization (GO:0034330)3.47481948
66synaptic vesicle maturation (GO:0016188)3.45006360
67intermediate filament cytoskeleton organization (GO:0045104)3.40345110
68renal filtration (GO:0097205)3.38846447
69cytoskeletal anchoring at plasma membrane (GO:0007016)3.38073938
70water homeostasis (GO:0030104)3.37485961
71skin development (GO:0043588)3.36034870
72regulation of fever generation (GO:0031620)3.33612417
73cardiac right ventricle morphogenesis (GO:0003215)3.33276122
74lung vasculature development (GO:0060426)3.32922621
75detection of calcium ion (GO:0005513)3.29320680
76intermediate filament-based process (GO:0045103)3.27841335
77interferon-gamma secretion (GO:0072643)3.26893453
78ATP hydrolysis coupled proton transport (GO:0015991)3.26571929
79energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.26571929
80regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.24981403
81cardiac conduction (GO:0061337)3.24047002
82regulation of beta-amyloid formation (GO:1902003)3.23436411
83positive regulation of keratinocyte differentiation (GO:0045618)3.22836205
84positive regulation of vasodilation (GO:0045909)3.22721597
85presynaptic membrane assembly (GO:0097105)3.22179411
86regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.21189442
87wound healing (GO:0042060)3.20688790
88positive regulation of positive chemotaxis (GO:0050927)3.19047358
89extracellular matrix disassembly (GO:0022617)3.17998903
90vocalization behavior (GO:0071625)3.17840428
91renal absorption (GO:0070293)3.15983190
92regulation of interleukin-8 secretion (GO:2000482)3.15335027
93startle response (GO:0001964)3.14084294
94thrombin receptor signaling pathway (GO:0070493)3.12865068
95positive regulation of Rho protein signal transduction (GO:0035025)3.11868329
96exocrine pancreas development (GO:0031017)3.08419155
97generation of neurons (GO:0048699)3.04735014
98focal adhesion assembly (GO:0048041)3.03837969
99cell-substrate adherens junction assembly (GO:0007045)3.03837969
100regulation of positive chemotaxis (GO:0050926)3.03613503
101renal system development (GO:0072001)3.02680411
102positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.01039044
103regulation of transforming growth factor beta production (GO:0071634)2.98506768
104wound healing, spreading of epidermal cells (GO:0035313)2.95512757
105peptide cross-linking (GO:0018149)2.94518611
106phagosome maturation (GO:0090382)2.92619296
107glial cell proliferation (GO:0014009)2.92494089
108cell communication involved in cardiac conduction (GO:0086065)2.92416298
109activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.92398124
110membrane raft organization (GO:0031579)2.91976172
111regulation of heat generation (GO:0031650)2.90215908
112serine transport (GO:0032329)2.90168251
113neurotransmitter secretion (GO:0007269)2.89814806
114atrioventricular valve morphogenesis (GO:0003181)2.89721252
115lymph vessel development (GO:0001945)2.89358106
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88225336
117cellular response to vitamin D (GO:0071305)2.86616292
118protein-cofactor linkage (GO:0018065)2.86056606
119cellular copper ion homeostasis (GO:0006878)2.86010983
120locomotory exploration behavior (GO:0035641)2.85821856
121regulation of keratinocyte differentiation (GO:0045616)2.85081838
122parturition (GO:0007567)2.84157535
123regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.82714249
124dicarboxylic acid catabolic process (GO:0043649)2.81786087
125regulation of epidermal cell differentiation (GO:0045604)2.81142893
126epidermal cell differentiation (GO:0009913)2.80782726
127neural crest cell development (GO:0014032)2.79959476
128positive regulation of synapse assembly (GO:0051965)2.79814445
129presynaptic membrane organization (GO:0097090)2.79458368
130morphogenesis of embryonic epithelium (GO:0016331)2.78959670
131wound healing, spreading of cells (GO:0044319)2.78893192
132regulation of metalloenzyme activity (GO:0048552)2.78744317
133positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.77044419
134iron ion import (GO:0097286)2.76867422
135iron ion transport (GO:0006826)2.75323093
136cardiac muscle cell action potential involved in contraction (GO:0086002)2.75053140
137sodium ion export (GO:0071436)2.73949336
138one-carbon compound transport (GO:0019755)2.73193138
139nucleotide transmembrane transport (GO:1901679)2.71188156
140negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.70816980
141female mating behavior (GO:0060180)2.70590263
142regulation of cardioblast differentiation (GO:0051890)2.70411431
143mammary gland epithelial cell proliferation (GO:0033598)2.69923760
144sensory perception of smell (GO:0007608)2.69770043
145postsynaptic membrane organization (GO:0001941)2.69702465
146negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69362889
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69146296
148negative regulation of dendrite development (GO:2000171)2.68601534
149multicellular organismal signaling (GO:0035637)2.67880767
150positive regulation of T cell migration (GO:2000406)2.67752594
151phenylpropanoid metabolic process (GO:0009698)2.67474482
152neurotransmitter-gated ion channel clustering (GO:0072578)2.67183927
153lung secretory cell differentiation (GO:0061140)2.66847035
154positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.66612690
155substrate-dependent cell migration (GO:0006929)2.65829221
156renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.65351117
157heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.65204623
158adherens junction assembly (GO:0034333)2.64793902
159adherens junction organization (GO:0034332)2.64684281
160ventricular cardiac muscle cell action potential (GO:0086005)2.64552024
161L-serine transport (GO:0015825)2.64051906
162mammary gland alveolus development (GO:0060749)2.63312804
163purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.63241241
1643-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.63241241
165regulation of phospholipase A2 activity (GO:0032429)2.62707018
166negative regulation of cell fate specification (GO:0009996)2.61032938
167* negative regulation of chondrocyte differentiation (GO:0032331)2.60609557
168regulation of female receptivity (GO:0045924)2.59213217
169positive regulation of protein export from nucleus (GO:0046827)2.58240628
170establishment of epithelial cell polarity (GO:0090162)2.58213850
171cardiac muscle cell action potential (GO:0086001)2.57970745
172peptidyl-tyrosine autophosphorylation (GO:0038083)2.56669064
173intestinal epithelial cell development (GO:0060576)2.55048010
174regulation of amyloid precursor protein catabolic process (GO:1902991)2.54322895
175dendrite development (GO:0016358)2.51057916
176keratinocyte proliferation (GO:0043616)2.50907106
177morphogenesis of an epithelial fold (GO:0060571)2.50233989
178gland morphogenesis (GO:0022612)2.50231459
179negative regulation of chemokine production (GO:0032682)2.49386880
180negative regulation of stem cell proliferation (GO:2000647)2.48816798
181regulation of sensory perception (GO:0051931)2.47110377
182regulation of sensory perception of pain (GO:0051930)2.47110377
183import into cell (GO:0098657)2.46922237
184NADH metabolic process (GO:0006734)2.46486774
185neuron cell-cell adhesion (GO:0007158)2.44587205
186regulation of synaptic transmission, GABAergic (GO:0032228)2.44007400
187gamma-aminobutyric acid signaling pathway (GO:0007214)2.43525484
188positive regulation of pseudopodium assembly (GO:0031274)2.40227851
189long-term synaptic potentiation (GO:0060291)2.39957657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF15_26573619_Chip-Seq_HEK293_Human3.48564082
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.47875877
3EZH2_22144423_ChIP-Seq_EOC_Human3.23563595
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.17781419
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06530539
6* SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.01118909
7* SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.01118909
8GBX2_23144817_ChIP-Seq_PC3_Human2.98391773
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.91211287
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64822357
11P63_26484246_Chip-Seq_KERATINOCYTES_Human2.64614210
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58480794
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38399691
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32975861
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28801147
16* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26730753
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.23230889
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.19203325
19* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16060433
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16060433
21* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12684265
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11123419
23* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10427770
24* EED_16625203_ChIP-ChIP_MESCs_Mouse2.09158444
25IGF1R_20145208_ChIP-Seq_DFB_Human2.04500628
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88475725
27* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88370938
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86311076
29ZNF263_19887448_ChIP-Seq_K562_Human1.85516591
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84085424
31* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80894992
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79509831
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78576103
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77036252
35TP53_18474530_ChIP-ChIP_U2OS_Human1.73809172
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73416807
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.72382936
38* TP63_23658742_ChIP-Seq_EP156T_Human1.72243142
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.70767980
40* UBF1/2_26484160_Chip-Seq_HMECs_Human1.69107754
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65800945
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.65218606
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65099392
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.58575338
45FUS_26573619_Chip-Seq_HEK293_Human1.58330537
46P300_19829295_ChIP-Seq_ESCs_Human1.57371583
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57243786
48* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55126637
49AHR_22903824_ChIP-Seq_MCF-7_Human1.51651645
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50679580
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.50452826
52TCF4_18268006_ChIP-ChIP_LS174T_Human1.47680742
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47289330
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.47108452
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.42903963
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42769914
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42064727
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41809713
59ATF3_27146783_Chip-Seq_COLON_Human1.41654866
60* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40421444
61RNF2_27304074_Chip-Seq_NSC_Mouse1.39906513
62CLOCK_20551151_ChIP-Seq_293T_Human1.38355307
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.38310742
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.36399343
65* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34623472
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.34396466
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34033859
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33635591
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33472385
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33472385
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33339172
72* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32479393
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31702205
74* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31640309
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30314966
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30015516
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.28296814
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27648984
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27174352
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26787199
81* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26447536
82* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26357962
83AR_21572438_ChIP-Seq_LNCaP_Human1.25999109
84* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25878626
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24978359
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24207304
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.23940274
88TP63_22573176_ChIP-Seq_HFKS_Human1.23388822
89* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23096628
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.22724653
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21907653
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21527057
93* SOX2_20726797_ChIP-Seq_SW620_Human1.21119654
94ER_23166858_ChIP-Seq_MCF-7_Human1.19097901
95* EP300_21415370_ChIP-Seq_HL-1_Mouse1.17441489
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17357594
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17165102
98AR_25329375_ChIP-Seq_VCAP_Human1.16813355
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15413372
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14026822
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13897432
102* ELK3_25401928_ChIP-Seq_HUVEC_Human1.13740507
103TCF4_22108803_ChIP-Seq_LS180_Human1.13580141
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12380357
105* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10786706
106BCAT_22108803_ChIP-Seq_LS180_Human1.10299199
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09923085
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09793841
109* REST_21632747_ChIP-Seq_MESCs_Mouse1.08744699
110VDR_22108803_ChIP-Seq_LS180_Human1.08322347
111TP53_16413492_ChIP-PET_HCT116_Human1.08277132
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07803163
113CJUN_26792858_Chip-Seq_BT549_Human1.07054051
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06129380
115ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05027134
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04360413
117* SMAD_19615063_ChIP-ChIP_OVARY_Human1.03102402
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02298743
119* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01658902
120* SOX2_21211035_ChIP-Seq_LN229_Gbm1.01338555
121IRF1_19129219_ChIP-ChIP_H3396_Human1.00928782
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00713000
123CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00104306
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.99535814
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98017969
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97745092
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96355910
128DROSHA_22980978_ChIP-Seq_HELA_Human0.95912042
129* NANOG_18555785_Chip-Seq_ESCs_Mouse0.95647037
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95315493
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94990646
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94944872
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94631271
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.92244880
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92040772
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.91765500
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91460959
138RACK7_27058665_Chip-Seq_MCF-7_Human0.90748134
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90386189
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.90175769
141KLF5_25053715_ChIP-Seq_YYC3_Human0.89500912
142AR_21909140_ChIP-Seq_LNCAP_Human0.88058941
143* BRD4_25478319_ChIP-Seq_HGPS_Human0.87416119
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84261087
145* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83362001
146NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82593573
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82444229
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79881043
149TBX20_22328084_ChIP-Seq_HEART_Mouse0.79272565
150TBX20_22080862_ChIP-Seq_HEART_Mouse0.79272565
151FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78807273
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78160034
153SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78119400
154TP53_22127205_ChIP-Seq_IMR90_Human0.77559696
155NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76961180
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.75951391
157GATA3_24758297_ChIP-Seq_MCF-7_Human0.73141446
158POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72276865
159WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.71048925
160TET1_21490601_ChIP-Seq_MESCs_Mouse0.70258280
161GATA6_25053715_ChIP-Seq_YYC3_Human0.68748115
162EGR1_19032775_ChIP-ChIP_M12_Human0.68299871
163TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.65916332
164GATA4_25053715_ChIP-Seq_YYC3_Human0.65824172
165TP53_23651856_ChIP-Seq_MEFs_Mouse0.65665904
166ELK4_26923725_Chip-Seq_MESODERM_Mouse0.65219999
167BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65088255
168ELK1_22589737_ChIP-Seq_MCF10A_Human0.63917367
169NANOG_18692474_ChIP-Seq_MEFs_Mouse0.62149587
170PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.57677648
171ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.57097030
172PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.55290193
173RUNX1_27514584_Chip-Seq_MCF-7_Human0.54072866
174STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.52935520
175ESR1_20079471_ChIP-ChIP_T-47D_Human0.52041547
176NANOG_18555785_ChIP-Seq_MESCs_Mouse0.50050971
177TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.49409270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.76156462
2MP0010368_abnormal_lymphatic_system3.55017100
3MP0003941_abnormal_skin_development3.53556531
4MP0003566_abnormal_cell_adhesion3.51323887
5MP0008789_abnormal_olfactory_epithelium3.43805293
6MP0004782_abnormal_surfactant_physiolog3.04658038
7MP0010678_abnormal_skin_adnexa2.96531142
8MP0005499_abnormal_olfactory_system2.95632456
9MP0005394_taste/olfaction_phenotype2.95632456
10* MP0001216_abnormal_epidermal_layer2.86448551
11MP0001849_ear_inflammation2.80634011
12MP0005409_darkened_coat_color2.80239869
13MP0002876_abnormal_thyroid_physiology2.79239476
14MP0001188_hyperpigmentation2.74790783
15MP0000566_synostosis2.70656886
16MP0000383_abnormal_hair_follicle2.58129046
17MP0005645_abnormal_hypothalamus_physiol2.49588678
18MP0002877_abnormal_melanocyte_morpholog2.46900892
19MP0000013_abnormal_adipose_tissue2.42375318
20MP0004381_abnormal_hair_follicle2.38824917
21MP0005023_abnormal_wound_healing2.38335786
22MP0005646_abnormal_pituitary_gland2.32657836
23MP0001346_abnormal_lacrimal_gland2.20224744
24MP0002254_reproductive_system_inflammat2.18984965
25MP0009745_abnormal_behavioral_response2.09750124
26MP0004264_abnormal_extraembryonic_tissu2.08722970
27MP0003183_abnormal_peptide_metabolism2.07056449
28MP0003787_abnormal_imprinting2.06767582
29MP0008438_abnormal_cutaneous_collagen1.92752432
30MP0009046_muscle_twitch1.92190877
31MP0000377_abnormal_hair_follicle1.91458799
32MP0002837_dystrophic_cardiac_calcinosis1.90425787
33MP0002249_abnormal_larynx_morphology1.90197420
34MP0000467_abnormal_esophagus_morphology1.87677176
35MP0002822_catalepsy1.83752986
36* MP0000762_abnormal_tongue_morphology1.80828850
37MP0001501_abnormal_sleep_pattern1.77734762
38MP0000049_abnormal_middle_ear1.76062166
39MP0002098_abnormal_vibrissa_morphology1.73936042
40MP0003315_abnormal_perineum_morphology1.72885063
41MP0002233_abnormal_nose_morphology1.71996473
42MP0003635_abnormal_synaptic_transmissio1.71302292
43MP0002653_abnormal_ependyma_morphology1.71267289
44MP0009053_abnormal_anal_canal1.65891466
45MP0002277_abnormal_respiratory_mucosa1.65677236
46MP0002064_seizures1.64073996
47MP0010030_abnormal_orbit_morphology1.62023508
48MP0000516_abnormal_urinary_system1.61755415
49MP0005367_renal/urinary_system_phenotyp1.61755415
50MP0001542_abnormal_bone_strength1.60199156
51MP0004043_abnormal_pH_regulation1.59415247
52MP0002060_abnormal_skin_morphology1.49237804
53MP0005171_absent_coat_pigmentation1.47642999
54MP0004885_abnormal_endolymph1.47185902
55MP0000537_abnormal_urethra_morphology1.44570490
56MP0001177_atelectasis1.43482359
57MP0002063_abnormal_learning/memory/cond1.42692254
58MP0004859_abnormal_synaptic_plasticity1.40767561
59MP0002796_impaired_skin_barrier1.39518485
60MP0000627_abnormal_mammary_gland1.37257712
61MP0002272_abnormal_nervous_system1.36917217
62MP0002909_abnormal_adrenal_gland1.34247609
63MP0009931_abnormal_skin_appearance1.33704011
64MP0003950_abnormal_plasma_membrane1.30547055
65MP0003385_abnormal_body_wall1.29481977
66MP0002557_abnormal_social/conspecific_i1.29136238
67MP0005360_urolithiasis1.28966187
68MP0005257_abnormal_intraocular_pressure1.27517331
69MP0008875_abnormal_xenobiotic_pharmacok1.27251347
70MP0000681_abnormal_thyroid_gland1.23604857
71MP0003938_abnormal_ear_development1.21595837
72* MP0001270_distended_abdomen1.19486473
73MP0004947_skin_inflammation1.18863376
74MP0003122_maternal_imprinting1.17852233
75* MP0000678_abnormal_parathyroid_gland1.17739812
76MP0003638_abnormal_response/metabolism_1.15015943
77MP0002572_abnormal_emotion/affect_behav1.15010906
78MP0000579_abnormal_nail_morphology1.14585253
79MP0002734_abnormal_mechanical_nocicepti1.14322253
80MP0001879_abnormal_lymphatic_vessel1.14052750
81MP0010352_gastrointestinal_tract_polyps1.12698161
82MP0002282_abnormal_trachea_morphology1.10842957
83MP0009379_abnormal_foot_pigmentation1.08560819
84MP0001191_abnormal_skin_condition1.08423598
85MP0000427_abnormal_hair_cycle1.08094664
86MP0003191_abnormal_cellular_cholesterol1.05551085
87MP0005085_abnormal_gallbladder_physiolo1.04057364
88MP0006054_spinal_hemorrhage1.03864753
89MP0005647_abnormal_sex_gland1.02528524
90MP0000367_abnormal_coat/_hair1.02089500
91MP0010771_integument_phenotype1.01474806
92MP0003195_calcinosis0.98671405
93MP0005275_abnormal_skin_tensile0.97676247
94MP0002938_white_spotting0.97593993
95MP0001984_abnormal_olfaction0.97377162
96* MP0002896_abnormal_bone_mineralization0.95802321
97MP0003755_abnormal_palate_morphology0.93610638
98MP0001486_abnormal_startle_reflex0.93320232
99MP0001970_abnormal_pain_threshold0.92932856
100MP0002735_abnormal_chemical_nociception0.92529023
101MP0010234_abnormal_vibrissa_follicle0.91974610
102MP0003880_abnormal_central_pattern0.91212631
103MP0004272_abnormal_basement_membrane0.91081167
104MP0001919_abnormal_reproductive_system0.90855363
105MP0003879_abnormal_hair_cell0.89872882
106MP0002184_abnormal_innervation0.89627237
107MP0000026_abnormal_inner_ear0.89417456
108MP0002295_abnormal_pulmonary_circulatio0.89113159
109MP0000858_altered_metastatic_potential0.85309560
110MP0002177_abnormal_outer_ear0.84340664
111* MP0000163_abnormal_cartilage_morphology0.84330527
112MP0008872_abnormal_physiological_respon0.83633168
113MP0004085_abnormal_heartbeat0.82766771
114MP0005197_abnormal_uvea_morphology0.82589635
115MP0002332_abnormal_exercise_endurance0.82289601
116MP0001851_eye_inflammation0.81930212
117MP0003329_amyloid_beta_deposits0.81887028
118MP0000003_abnormal_adipose_tissue0.80673683
119MP0002108_abnormal_muscle_morphology0.80625217
120MP0001485_abnormal_pinna_reflex0.80249145
121MP0000647_abnormal_sebaceous_gland0.79798516
122MP0000538_abnormal_urinary_bladder0.77687068
123MP0003705_abnormal_hypodermis_morpholog0.77416157
124MP0003091_abnormal_cell_migration0.77361464
125MP0005501_abnormal_skin_physiology0.76871449
126MP0000230_abnormal_systemic_arterial0.76337135
127MP0002736_abnormal_nociception_after0.76216651
128MP0001958_emphysema0.74912767
129MP0005503_abnormal_tendon_morphology0.74873270
130MP0001881_abnormal_mammary_gland0.74022882
131MP0002009_preneoplasia0.73879154
132MP0010386_abnormal_urinary_bladder0.73269706
133MP0004484_altered_response_of0.72672173
134MP0001963_abnormal_hearing_physiology0.71513568
135MP0003453_abnormal_keratinocyte_physiol0.71505560
136MP0002733_abnormal_thermal_nociception0.71419907
137* MP0009250_abnormal_appendicular_skeleto0.71305776
138MP0003045_fibrosis0.71089962
139MP0005248_abnormal_Harderian_gland0.70649418
140MP0000733_abnormal_muscle_development0.70027714
141MP0002234_abnormal_pharynx_morphology0.69202819
142MP0001340_abnormal_eyelid_morphology0.66646111
143MP0001243_abnormal_dermal_layer0.65896284
144MP0003300_gastrointestinal_ulcer0.64748706
145MP0005193_abnormal_anterior_eye0.63077376
146MP0002111_abnormal_tail_morphology0.58736455
147MP0005164_abnormal_response_to0.58681205
148MP0005508_abnormal_skeleton_morphology0.58596704
149MP0002089_abnormal_postnatal_growth/wei0.55542590
150MP0000462_abnormal_digestive_system0.55282415
151MP0002697_abnormal_eye_size0.51096298
152MP0009840_abnormal_foam_cell0.49457414
153MP0005623_abnormal_meninges_morphology0.47315304
154MP0001915_intracranial_hemorrhage0.46459284
155MP0005165_increased_susceptibility_to0.45991160
156MP0003448_altered_tumor_morphology0.45745684
157MP0000750_abnormal_muscle_regeneration0.45520647
158MP0000470_abnormal_stomach_morphology0.43868667
159MP0003828_pulmonary_edema0.42233506
160MP0002168_other_aberrant_phenotype0.41895273
161* MP0000432_abnormal_head_morphology0.41702363
162MP0005451_abnormal_body_composition0.41280214
163MP0004858_abnormal_nervous_system0.40228273
164MP0001661_extended_life_span0.39275775
165MP0008932_abnormal_embryonic_tissue0.38507131
166MP0003075_altered_response_to0.37946888

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)8.48259922
2Abnormality of nail color (HP:0100643)8.23313268
3Thick nail (HP:0001805)7.49290108
4Ridged nail (HP:0001807)5.96034133
5Focal motor seizures (HP:0011153)5.69279414
6Palmar hyperkeratosis (HP:0010765)5.62982541
7Onycholysis (HP:0001806)5.50836797
8Atonic seizures (HP:0010819)4.78209751
9Abnormal blistering of the skin (HP:0008066)4.55636105
10Fragile nails (HP:0001808)4.53358861
11Pili torti (HP:0003777)4.34802956
12Hyperventilation (HP:0002883)4.28605385
13Febrile seizures (HP:0002373)4.16884447
14Abnormality of proline metabolism (HP:0010907)4.04359245
15Hydroxyprolinuria (HP:0003080)4.04359245
16Abnormal hair whorl (HP:0010721)3.87479461
17Selective tooth agenesis (HP:0001592)3.85654253
18Fragile skin (HP:0001030)3.81997845
19Abnormal hair laboratory examination (HP:0003328)3.76118393
20Milia (HP:0001056)3.71780297
21Split foot (HP:0001839)3.59732604
22Atrophic scars (HP:0001075)3.59384782
23Palpitations (HP:0001962)3.58520257
24Amniotic constriction ring (HP:0009775)3.57246176
25Abnormality of placental membranes (HP:0011409)3.57246176
26Epileptic encephalopathy (HP:0200134)3.55915885
27Oral leukoplakia (HP:0002745)3.52422892
28Plantar hyperkeratosis (HP:0007556)3.46164339
29Sparse scalp hair (HP:0002209)3.35622814
30Spastic diplegia (HP:0001264)3.34885776
31Sparse eyelashes (HP:0000653)3.28464897
32Ankyloglossia (HP:0010296)3.14168701
33Parakeratosis (HP:0001036)3.10777313
34Pheochromocytoma (HP:0002666)3.07615809
35Narrow nasal bridge (HP:0000446)3.06345855
36Poor suck (HP:0002033)2.98513322
37Absent eyebrow (HP:0002223)2.95880881
38Popliteal pterygium (HP:0009756)2.94468419
39Dry hair (HP:0011359)2.93276942
40Labial hypoplasia (HP:0000066)2.88126245
41Neuroendocrine neoplasm (HP:0100634)2.84380777
42Anonychia (HP:0001798)2.83910678
43Congenital sensorineural hearing impairment (HP:0008527)2.82317532
44Gout (HP:0001997)2.78537135
45Absence seizures (HP:0002121)2.74380793
46Asymmetry of the thorax (HP:0001555)2.74035873
47Hypoplastic labia majora (HP:0000059)2.73361583
48Carious teeth (HP:0000670)2.69273838
49Absent eyelashes (HP:0000561)2.65468618
50Hydroureter (HP:0000072)2.62221694
51Increased purine levels (HP:0004368)2.60082884
52Hyperuricemia (HP:0002149)2.60082884
53Abnormality of oral frenula (HP:0000190)2.56843443
54Fatigable weakness (HP:0003473)2.54701057
55Abnormality of the neuromuscular junction (HP:0003398)2.54701057
56Hypoplastic female external genitalia (HP:0012815)2.50423400
57Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.50057760
58Advanced eruption of teeth (HP:0006288)2.49380012
59Hyperphosphatemia (HP:0002905)2.48591575
60Abnormality of the labia majora (HP:0012881)2.47105974
61Alveolar cell carcinoma (HP:0006519)2.46455667
62Abnormality of the axillary hair (HP:0100134)2.45440712
63Abnormality of secondary sexual hair (HP:0009888)2.45440712
64Urethral obstruction (HP:0000796)2.43134255
65Abnormality of the labia minora (HP:0012880)2.37238045
66Focal seizures (HP:0007359)2.35981526
67Amelogenesis imperfecta (HP:0000705)2.33904400
68Abnormal mitochondria in muscle tissue (HP:0008316)2.33144954
69Oligomenorrhea (HP:0000876)2.32374557
70Thickened helices (HP:0000391)2.31404282
71Long foot (HP:0001833)2.31205182
72Hyperhidrosis (HP:0000975)2.30137977
73Abnormality of the salivary glands (HP:0010286)2.30020631
74Blue irides (HP:0000635)2.29948475
75Palmoplantar keratoderma (HP:0000982)2.28798556
76Curly hair (HP:0002212)2.26474354
77Abnormality of the phalanges of the 5th finger (HP:0004213)2.24938924
78Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.22508055
79Sleep apnea (HP:0010535)2.20464817
80Nail dystrophy (HP:0008404)2.19927273
81Resting tremor (HP:0002322)2.19401687
82Corneal erosion (HP:0200020)2.18534842
83Erythema (HP:0010783)2.16871372
84Aplasia cutis congenita (HP:0001057)2.15089899
85Abnormality of purine metabolism (HP:0004352)2.14662741
86Palpebral edema (HP:0100540)2.13170826
87Abnormality of the fingernails (HP:0001231)2.12292280
88Neoplasm of the tracheobronchial system (HP:0100552)2.12059460
89Type 2 muscle fiber atrophy (HP:0003554)2.09010865
90Esophageal atresia (HP:0002032)2.08064453
91Nasolacrimal duct obstruction (HP:0000579)2.07164356
92Hypoplasia of dental enamel (HP:0006297)2.06494060
93Epidermoid cyst (HP:0200040)2.06472684
94Xerostomia (HP:0000217)2.05354069
95Ectropion (HP:0000656)2.05343241
96Acute necrotizing encephalopathy (HP:0006965)2.05020981
97Hepatocellular necrosis (HP:0001404)2.03897301
98Bronchomalacia (HP:0002780)2.03619033
99Dialeptic seizures (HP:0011146)2.03357053
100Blepharitis (HP:0000498)2.02799257
101Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00690344
102Lip pit (HP:0100267)1.98931482
103Syncope (HP:0001279)1.98533736
104Breast hypoplasia (HP:0003187)1.98079205
105Laryngomalacia (HP:0001601)1.97749376
106Neurofibrillary tangles (HP:0002185)1.97348214
107Hypotrichosis (HP:0001006)1.97321379
108Abnormality of the labia (HP:0000058)1.96275763
109Ventricular tachycardia (HP:0004756)1.96137985
110Septate vagina (HP:0001153)1.96076027
111Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.95498554
112Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91989580
113White forelock (HP:0002211)1.91049550
114Generalized tonic-clonic seizures (HP:0002069)1.90650319
115Hypodontia (HP:0000668)1.88599330
116Growth hormone excess (HP:0000845)1.87523783
117Generalized hypotonia (HP:0001290)1.87061172
118Multifactorial inheritance (HP:0001426)1.86202596
119Progressive inability to walk (HP:0002505)1.85531121
120Abnormal sex determination (HP:0012244)1.85084976
121Sex reversal (HP:0012245)1.85084976
122Progressive macrocephaly (HP:0004481)1.84912615
123Corneal dystrophy (HP:0001131)1.83633866
124Trismus (HP:0000211)1.83562534
125Cheilitis (HP:0100825)1.83406025
126Arterial tortuosity (HP:0005116)1.83295796
127Polyphagia (HP:0002591)1.82293578
128Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.81910841
129Hoarse voice (HP:0001609)1.81568934
130Weak cry (HP:0001612)1.80359009
131Woolly hair (HP:0002224)1.78690626
132Palmoplantar hyperkeratosis (HP:0000972)1.77580921
133Neoplasm of head and neck (HP:0012288)1.77563792
134Esophageal neoplasm (HP:0100751)1.77563792
135Neoplasm of the peripheral nervous system (HP:0100007)1.77406706
136Submucous cleft hard palate (HP:0000176)1.75065174
137True hermaphroditism (HP:0010459)1.74652550
138Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74318882
139Follicular hyperkeratosis (HP:0007502)1.74276734
140Pterygium (HP:0001059)1.74273074
141Alopecia of scalp (HP:0002293)1.74106102
142Tubulointerstitial nephritis (HP:0001970)1.72576773
143Short nail (HP:0001799)1.72340915
144Ureteral stenosis (HP:0000071)1.72317927
145Natal tooth (HP:0000695)1.72108109
146Skin ulcer (HP:0200042)1.69888742
147Ventricular arrhythmia (HP:0004308)1.68827338
148Absent hair (HP:0002298)1.68118039
149Menstrual irregularities (HP:0000858)1.67926315
150Abnormality of the lacrimal duct (HP:0011481)1.66106255
151Death in infancy (HP:0001522)1.65377673
152Poikiloderma (HP:0001029)1.64290342
153Cerebral inclusion bodies (HP:0100314)1.63617493
154Autoamputation (HP:0001218)1.63288779
155Periodontitis (HP:0000704)1.63052085
156Hypoplasia of the uterus (HP:0000013)1.62606641
157Squamous cell carcinoma (HP:0002860)1.60434615
158Dehydration (HP:0001944)1.59596769
159Premature loss of primary teeth (HP:0006323)1.58641888
160Vascular tortuosity (HP:0004948)1.57493597
161Ureteral obstruction (HP:0006000)1.57078586
162Cardiovascular calcification (HP:0011915)1.55178144
163Tibial bowing (HP:0002982)1.53243795
164Abnormality of permanent molar morphology (HP:0011071)1.52745044
165Abnormality of the dental root (HP:0006486)1.52745044
166Taurodontia (HP:0000679)1.52745044
167* Oligodontia (HP:0000677)1.52445668
168Vascular calcification (HP:0004934)1.52190631
169Abnormality of the nasolacrimal system (HP:0000614)1.51605118
170Broad face (HP:0000283)1.49006967
171Neonatal onset (HP:0003623)1.47979430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF4.64320074
2CASK4.40043634
3AKT34.20308660
4MST43.97584145
5MET3.71344041
6MAP3K33.67318904
7FRK3.50069483
8EPHB23.49135278
9NTRK13.23823220
10PIM23.16318286
11TSSK63.10295202
12RIPK12.59260557
13TGFBR12.39154943
14ERBB42.36167529
15PTK22.35823082
16MAP3K22.24664682
17PRPF4B2.03941388
18TGFBR22.01462291
19LATS21.98261893
20STK241.95103390
21FLT31.93687063
22PAK31.92094581
23PDGFRA1.90285123
24EPHA21.84399153
25PAK41.82221645
26ERBB31.79940500
27MAP2K71.71277209
28NTRK31.70708724
29LATS11.62444295
30PRKCE1.60306809
31INSRR1.59715920
32EPHB11.58368197
33FER1.56186133
34LMTK21.55125165
35BMPR1B1.55103001
36KSR21.50744848
37BMPR21.45983804
38MAP3K121.45565544
39ERN11.41128050
40PDK31.35443412
41PDK41.35443412
42SIK31.30244252
43CDK81.28319344
44TAOK21.27577783
45TAOK11.24879003
46GRK51.21052587
47RAF11.18818863
48SIK11.16463538
49TRIB31.14180730
50BCR1.10873146
51ADRBK21.07620426
52PLK21.05052624
53BRAF1.04588956
54NTRK21.03948022
55PDK21.01047059
56MOS0.95539394
57IRAK20.95055652
58MAP3K110.93043338
59SGK20.90322252
60PRKCG0.89697157
61NME20.88790205
62CAMK2G0.88514742
63RPS6KA20.88348326
64MAP3K140.83724546
65PBK0.83552123
66CAMK2A0.83315155
67MST1R0.82724070
68STK380.82498215
69TRPM70.82109712
70PDGFRB0.81634419
71PTK60.81352998
72MAP3K40.80836396
73SMG10.80507622
74HIPK20.77790302
75CSF1R0.77007140
76MUSK0.75883709
77IRAK30.75084793
78MAP2K10.73603016
79MAP3K10.73172701
80TTN0.72276113
81ZAK0.72120492
82TESK10.71617021
83SGK4940.70313023
84SGK2230.70313023
85MKNK20.69720273
86CDK120.69532681
87BMX0.68647462
88PRKCI0.67345253
89RET0.66944545
90ADRBK10.66630395
91MYLK0.66290616
92DAPK20.64435165
93MAP3K80.64340032
94EPHA30.63056544
95FGFR20.60927261
96CDK30.59477794
97MAP2K40.59023474
98CAMK2B0.55318252
99KSR10.54757827
100MINK10.54744927
101MAP2K30.54674198
102ILK0.54563651
103MAP3K130.53885686
104STK38L0.53749124
105STK30.53541324
106PKN10.52767354
107MAPKAPK30.52345426
108MAP3K60.52143268
109SGK30.51043311
110CAMK10.50773839
111PAK20.48213799
112TNIK0.47633135
113NEK60.47369228
114LIMK10.46413134
115ROCK10.45386313
116ABL20.44767941
117ERBB20.43476898
118CDC42BPA0.42380997
119MATK0.41740519
120PRKD20.41318257
121MTOR0.40879016
122CAMK40.39891985
123RPS6KC10.38305816
124RPS6KL10.38305816
125DYRK1B0.38115220
126RPS6KA10.37107393
127IGF1R0.36476047
128STK100.36194448
129WNK40.35843254
130CAMK2D0.34901390
131CDK50.33501604
132RPS6KB20.31608191
133PKN20.30759795
134GSK3A0.30421197
135DYRK1A0.30055765
136PRKCA0.29672159
137SRC0.29532268
138WNK10.29004738
139PRKACA0.28674855
140PTK2B0.28494668
141MAPKAPK20.28279049
142PRKACB0.27628391
143PRKCZ0.27298550
144PRKG20.27166945
145IKBKB0.26915841
146JAK30.26623681
147RPS6KB10.26401417
148GRK70.26167024
149RPS6KA40.25442408
150* PRKCB0.24926939
151MAP3K90.24727547
152RPS6KA60.24336173
153MAPK30.24009796
154INSR0.22888662
155YES10.22806346
156MKNK10.21851465
157EPHA40.21662331
158ROCK20.21585247
159LRRK20.16576298
160PHKG10.16514724
161PHKG20.16514724
162PRKD10.16499318

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004305.16669325
2Collecting duct acid secretion_Homo sapiens_hsa049663.70201050
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.25356646
4Small cell lung cancer_Homo sapiens_hsa052223.09303507
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.91251295
6Focal adhesion_Homo sapiens_hsa045102.90899662
7Synaptic vesicle cycle_Homo sapiens_hsa047212.73782295
8Vibrio cholerae infection_Homo sapiens_hsa051102.59694629
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.46903448
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.43724590
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43717466
12Steroid biosynthesis_Homo sapiens_hsa001002.43422551
13Nicotine addiction_Homo sapiens_hsa050332.38975991
14Rheumatoid arthritis_Homo sapiens_hsa053232.25941885
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.21328822
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.21257225
17p53 signaling pathway_Homo sapiens_hsa041152.06710927
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05862298
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.03951708
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.90451426
21Oxidative phosphorylation_Homo sapiens_hsa001901.73245165
22Chemical carcinogenesis_Homo sapiens_hsa052041.72756913
23Toxoplasmosis_Homo sapiens_hsa051451.69040354
24GABAergic synapse_Homo sapiens_hsa047271.64964564
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.63042059
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.52929805
27Butanoate metabolism_Homo sapiens_hsa006501.50972462
28Thyroid cancer_Homo sapiens_hsa052161.46198229
29Type I diabetes mellitus_Homo sapiens_hsa049401.44225601
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42305234
31Long-term depression_Homo sapiens_hsa047301.39217144
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34124503
33Prion diseases_Homo sapiens_hsa050201.32622144
34Chronic myeloid leukemia_Homo sapiens_hsa052201.30587736
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30300402
36Morphine addiction_Homo sapiens_hsa050321.27660813
37Retinol metabolism_Homo sapiens_hsa008301.26582305
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.24677857
39MicroRNAs in cancer_Homo sapiens_hsa052061.21815773
40Phagosome_Homo sapiens_hsa041451.21603409
41PI3K-Akt signaling pathway_Homo sapiens_hsa041511.21451694
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21095246
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19569166
44Hippo signaling pathway_Homo sapiens_hsa043901.18436740
45Pathways in cancer_Homo sapiens_hsa052001.18318361
46Pancreatic cancer_Homo sapiens_hsa052121.14978085
47Renal cell carcinoma_Homo sapiens_hsa052111.14877635
48Serotonergic synapse_Homo sapiens_hsa047261.13430664
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12291238
50VEGF signaling pathway_Homo sapiens_hsa043701.11679430
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11650647
52Shigellosis_Homo sapiens_hsa051311.11493657
53Sulfur metabolism_Homo sapiens_hsa009201.09949650
54Sphingolipid metabolism_Homo sapiens_hsa006001.08805693
55Protein digestion and absorption_Homo sapiens_hsa049741.08795124
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07276631
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06672138
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.06229393
59Starch and sucrose metabolism_Homo sapiens_hsa005001.04387758
60Melanoma_Homo sapiens_hsa052181.01687738
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99624892
62African trypanosomiasis_Homo sapiens_hsa051430.98023227
63Endometrial cancer_Homo sapiens_hsa052130.97969289
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97023258
65Phenylalanine metabolism_Homo sapiens_hsa003600.96290829
66Amphetamine addiction_Homo sapiens_hsa050310.94925579
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.93419267
68Salmonella infection_Homo sapiens_hsa051320.91037751
69Long-term potentiation_Homo sapiens_hsa047200.90092262
70Cholinergic synapse_Homo sapiens_hsa047250.90053869
71Insulin secretion_Homo sapiens_hsa049110.88758606
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88520701
73Circadian entrainment_Homo sapiens_hsa047130.88061900
74Endocytosis_Homo sapiens_hsa041440.88013410
75Malaria_Homo sapiens_hsa051440.86970932
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85638008
77Gastric acid secretion_Homo sapiens_hsa049710.84700130
78Dorso-ventral axis formation_Homo sapiens_hsa043200.84483560
79Taste transduction_Homo sapiens_hsa047420.83974431
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83699642
81Dopaminergic synapse_Homo sapiens_hsa047280.79813771
82Notch signaling pathway_Homo sapiens_hsa043300.79403384
83Olfactory transduction_Homo sapiens_hsa047400.79256587
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79159266
85Insulin signaling pathway_Homo sapiens_hsa049100.78644857
86Inositol phosphate metabolism_Homo sapiens_hsa005620.77121346
87Tight junction_Homo sapiens_hsa045300.75413486
88Salivary secretion_Homo sapiens_hsa049700.74729001
89Acute myeloid leukemia_Homo sapiens_hsa052210.74481772
90Glutamatergic synapse_Homo sapiens_hsa047240.72000574
91N-Glycan biosynthesis_Homo sapiens_hsa005100.71699776
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71247979
93Calcium signaling pathway_Homo sapiens_hsa040200.69987800
94Alzheimers disease_Homo sapiens_hsa050100.67954722
95beta-Alanine metabolism_Homo sapiens_hsa004100.67623355
96Apoptosis_Homo sapiens_hsa042100.65378391
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65121507
98Cocaine addiction_Homo sapiens_hsa050300.64704633
99Prostate cancer_Homo sapiens_hsa052150.63597407
100Gap junction_Homo sapiens_hsa045400.63050201
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.61771866
102Parkinsons disease_Homo sapiens_hsa050120.61134557
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59918360
104Ovarian steroidogenesis_Homo sapiens_hsa049130.58693890
105Glioma_Homo sapiens_hsa052140.58388237
106Renin secretion_Homo sapiens_hsa049240.58318614
107GnRH signaling pathway_Homo sapiens_hsa049120.58147792
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58064329
109Non-small cell lung cancer_Homo sapiens_hsa052230.57337958
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.56744980
111Axon guidance_Homo sapiens_hsa043600.55930140
112Bladder cancer_Homo sapiens_hsa052190.55448573
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54737737
114Hedgehog signaling pathway_Homo sapiens_hsa043400.52620130
115Hepatitis C_Homo sapiens_hsa051600.50971844
116Melanogenesis_Homo sapiens_hsa049160.49972723
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47851450
118Dilated cardiomyopathy_Homo sapiens_hsa054140.47761948
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47513744
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.46547454
121Pertussis_Homo sapiens_hsa051330.46167907
122Fatty acid elongation_Homo sapiens_hsa000620.46076215
123Glutathione metabolism_Homo sapiens_hsa004800.43991108
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42934730
125HIF-1 signaling pathway_Homo sapiens_hsa040660.42429220
126mTOR signaling pathway_Homo sapiens_hsa041500.42270125
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.41316805
128Fatty acid biosynthesis_Homo sapiens_hsa000610.41000785
129Rap1 signaling pathway_Homo sapiens_hsa040150.40998510
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40553929
131cAMP signaling pathway_Homo sapiens_hsa040240.40454644
132TNF signaling pathway_Homo sapiens_hsa046680.40235440
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38118660
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37911962
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35886263
136Pyruvate metabolism_Homo sapiens_hsa006200.35843530
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34940154
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34909251
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34547236
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33232697
141Galactose metabolism_Homo sapiens_hsa000520.32906986
142Lysosome_Homo sapiens_hsa041420.32813436
143Tyrosine metabolism_Homo sapiens_hsa003500.32139059
144Estrogen signaling pathway_Homo sapiens_hsa049150.31965793
145Hematopoietic cell lineage_Homo sapiens_hsa046400.31796834
146Pancreatic secretion_Homo sapiens_hsa049720.30804167
147Adherens junction_Homo sapiens_hsa045200.30596483
148TGF-beta signaling pathway_Homo sapiens_hsa043500.29694503
149Colorectal cancer_Homo sapiens_hsa052100.29489252
150ECM-receptor interaction_Homo sapiens_hsa045120.28917912
151Wnt signaling pathway_Homo sapiens_hsa043100.27691792
152Proteoglycans in cancer_Homo sapiens_hsa052050.27570537
153Type II diabetes mellitus_Homo sapiens_hsa049300.27256942
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.26832659
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.26830406
156Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26197142
157Fructose and mannose metabolism_Homo sapiens_hsa000510.25788134
158Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25767949
159Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25522764
160ErbB signaling pathway_Homo sapiens_hsa040120.25522443
161Caffeine metabolism_Homo sapiens_hsa002320.25441810
162Phototransduction_Homo sapiens_hsa047440.25423540
163Basal cell carcinoma_Homo sapiens_hsa052170.24948773
164Ras signaling pathway_Homo sapiens_hsa040140.24555644
165FoxO signaling pathway_Homo sapiens_hsa040680.23523519
166Amoebiasis_Homo sapiens_hsa051460.23132435

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